NOTESandCOMMENTSThis issue combines graduation andreunion. The June Convocation addedsixty-three new graduates to our alumnirolls. Their pictures and curricula vitaeare shown on pp. 9 to 13; their honorsand awards on p. 19.Sixteen participated in the eighteenthSenior Scientific Session. The committeein charge was Richard K. Blaisdell,'48, chairman, George E. Block, Dan­iel L. Harris, Ruth Rhines, and LeonO. Jacobson, '39. The attendance wasvery good-junior and senior medicalclasses and clinics were cancelled for theall-day program. We had a dinner for theparticipants, their sponsors, and theCommittee afterwards at the Center forContinuing Education.The fifth annual Medical Alumni Prizewent to Bruce Bolasny with a checkfor one hundred dollars. A new bronzeplaque has been mounted on the wallnear the Student Lounge which reads:"The Medical Alumni Prize is awardedto the student giving the best presen­tation of a research paper at the SeniorScientific Session.1960 JOSEPH J ARABAK1961 DAVID G. ANDERSON1962 EDWARD B. CROWELL, JR.1963 JOHN SCHNEIDER1964 BRUCE BOLASNY"The Reunion Banquet has taken onsomething of a family character. Seniors'wives, their parents, their aunts anduncles, and sometimes even their ownchildren come to share this part of thegraduation program with them. The ad­ministration of the Hippocratic Oathadds a bit of ceremony-a solemn mo­ment in a gala evening. Dr. DouglasBuchanan provided each of the gradu­ates with a printed copy of the Oathin the original Greek, the Old Englishtext, and a translation into modern Eng­lish. He spoke briefly of its history inthe practice of medicine and surgery andthen read the Oath to the seniors whostood to signify their acceptance. Itwas a fine sight as these pictures show.2 MEDICAL ALUMNI BULLETINWe have rarely had as large a repre­sentation of a fifty-year class as thefifteen men-half the remaining mem­bership-of the Rush Medical Collegeclass of 1914, who joined us this year.You may read about them on p. 14.Willis J. Potts was the banquet speak­er. His delightful talk, which he called"Through the Retrospectoscope" isprinted here, beginning on p. 4.Dr. Potts, a Rush graduate of 1923,is famous for his work on the surgicaltreatment of congenital heart disease.While this was in press, the happy an­nouncement comes that Konrad EmilBloch is the recipient of the Nobel Prizein medicine. We salute him for the dis­tinction he brings himself and to theUniversity of Chicago. His work on cho­lesterol biosynthesis for which the awardwas presented, was done while he wason our faculty. There is a brief bio­graphical sketch of Dr. Bloch on p. 7.Last year the Class of 1963 presenteda brand-new blackboard to P-117, in re­membrance of their many long hoursfacing the old one. The new blackboardbears a commemorative plaque on which,we hope, many students in the years tocome will rest their eyes.The true spirit of innovation was pres­ent when the Class of 1964 chose theirgift to the Medical School. They relieveda rather critical situation in the studentlounge by presenting a gift of individualmail-boxes for members of the juniorand senior classes. The mail-boxes alsobear a plaque inscribed with the donors'year of graduation.On behalf of present and future stu­dents we would like to thank both classesfor their thoughtfulness and generosity.Cover and Seniors' pictures byARCHIE LIEBERMANReunion pictures byJOEL SNYDERMEDICAL ALUMNI BULLETIN 3THROUGH THE RETROSPECT-O-SCOPEBy WILLIS J. POTTS, '23Professor Emeritus of Surgery, Northwestern University,and Staff Surgeon, Children'sMemorial HospitalI love The University of Chicago.Had it not been for the kindness ofmany of its people-above and beyondthe call of duty-I wouldn't be here thisevening as an alumnus.The First World War in France wasover in November, 1918. I was at theport of embarkation on my way home inDecember when I was booked with fiveothers for a special mission in Germanyand Italy; consequently, I didn't getback to my home in Holland, Michiganbefore the summer of 1919. I faced areal problem; I needed a course in quali­tative chemistry to be eligible for ad­mission to medical school that fall. Ihad no idea how I could get this coursebut was advised to go to The Universityof Chicago. I had never seen the Uni­versity of Chicago campus, but withfaith in my heart I took the overnightferry boat from Holland to Chicago andarrived on an unusually hot day in mid­July.When I eventually found my wayfrom the end of the Jackson Park "L"to the University campus, I was directedto the dean's office, where I met MissEsther Tarkington, now Mrs. TonyCrooks. She looked at the long, lanky,perspiring, forlorn ex-soldier in an ill­fitting second-hand suit, heard my story,and suggested I set my suitcase in heroffice and sit down while she did sometelephoning. After a time she reappearedand said I was to go immediately to the" MEDICAL ALUMNI BULLETINPOTTSRyerson Building to see Dr. JuliusStieglitz, head of the Department ofChemistry, about this course in qualita­tive analysis. I went to his office where Ifound him, in a white coat with a fewholes in it, seated at his rolltop desk. Ican see him now as plainly as forty-fiveyears ago: his pointed, greying beard,his deep brown eyes, his balding head.Those of you who knew Dr. Steiglitz re­member how he spoke, in a slow, meas­ured tone."So you have just been dischargedfrom the Army," he said. Miss Tarking­ton had briefed him on that. "And whatdid you do in the Army?" I told him Ihad been in the Chemical Warfare Ser­vice in France, instructing soldiers inthe use of gas masks. "Is that so?" hesaid, "So was I in the Chemical WarfareService." He then proceeded to tellabout his work for the government insearch of the best ingredients to put inthe gas mask canisters to filter outchlorine, phosgene, and mustard gases.Finally he said, "Hmmm, so you wantto take a course in qualitative chemistrythis summer? You know there are onlynineteen school days left. I'm afraid youcan't complete the course in so short aperiod."What does one say at such a time­nothing. Maybe I just looked sad. As Iheaded for the door, he said, "Wait aminute. I am leaving for my vacationin the Catskills tomorrow. If you want to take this course by correspondenceyou can do the laboratory work here inresidence and send your reports to mysummer address. Would you like to tryit?" I couldn't believe my ears. Ofcourse I'd try it. He then called some­body connected with extension coursesand said to me, "Go over and registerand you can start work tomorrow morn­ing." I rented a room on the corner ofUniversity Avenue and 55th Street, andwas at the laboratory the next morning.All this happened in less than twenty­four hours. Each day from the time thelaboratory opened until it closed I didthe required laboratory work, and in theevening wrote reports and answers tolessons given me by the correspondencedepartment.Like clock-work Dr. Stieglitz's correc­tions of my work, his criticisms andsuggestions were returned three times aweek by mail. Speeded-up work in thedepartment of chemistry was possiblebecause of the help of Mrs. Sonja Law­rence, working on a fellowship in chem­istry and appointed as my supervisor. Ididn't know anything about chemistry.One elemental course in college was all Ihad had. Valences were relatively newat the time. Carefully and patientlySonja guided me through the mysteriesof valences-one for hydrogen, two foroxygen, four for carbon, and so forth.As a sequel to the course I had to ana­lyze a chemical unknown. Do you knowwhat Sonja Lawrence did? She gave mea mixture of chemicals-cobalt, copper,antimony, etc., not all in one solution,but in crystalline form. I separated theeasily recognizable crystals, applied theproper identifying tests to each, andpassed. How could I miss?On the nineteenth day I took theexamination, went home to Holland,Michigan, got a job and waited. Thefollowing month a letter came fromDean Dodson's office of The Universityof Chicago Medical School. One looks atsuch an envelope for some time beforeopening it, because contained therein isone's future. No use just sitting thereholding the letter; open it and learn thetruth. There it was-a B in chemistryand admission to the medical school.Jumping around like a cat with fits, Ishouted, "I passed, I'm in, I passed, I'min." Mother thought that I had gone offmy rocker.We're not through yet with the won­derful people at The University of Chi­cago. When I registered, another secre­tary said, "You know, you are eligiblefor a LaVerne Noyes Scholarship to payyour tuition." (No wonder I have al­ways loved secretaries.) But how couldI be eligible for a scholarship? Luckyfor me-no grades were needed. Theonly requirement was Army service, andI had had almost two years of that.All these wonderful things happenedin a matter of weeks after almost twoyears of fruitless service in "making theworld safe for democracy."There is a sequel to the story aboutDr. Julius Stieglitz. Five years later atthe Presbyterian Hospital on theKretschner service, who should come inas a patient but the professor himself.When I walked into the room to takehis history, I said, "I'm sure you don'tremember a lost student you guidedthrough a course in chemistry." No, ofcourse he didn't; he had seen me onlyfor a few minutes. When I recalled thestory his only comment was, "It appearsthat my judgment was correct." Suchgraciousness! He could have called meevery hour every night while he was inthe hospital and I would have beenthere. But people like that don't demandsuch service. They are the easiest pa­tients to care for, and would rather suf­fer some pain than disturb a doctor-oreven an intern.The almost two years of internshipwere wonderful. No surgical residents tolord it over the lowly interns. In thosedays we were directly responsible to theattending man for the care 'of his pa­tients. Thirty surgical patients under thecare of one intern-imagine that. Ofcourse, postoperative care was simple.We had two drugs: aspirin and mor­phine. If a patient needed fluid, we put1500 cc under the skin. Intravenous ad­ministration invariably shot the mercuryout of the top of the thermometer. Wepractically carried a stomach tube inour back pockets to treat postoperativegastric dilatation. Constant suctionhadn't been invented. If a patient'sbowels didn't move, he got a 1-2-3 ene­ma. If that failed we doubled the blastwith a 2-4-6 charge. A blood transfusionwas called for after the priest had cometo administer last rites. Amazing howpatients somehow survived.Those were the days when an internknew all the answers, stuck out his neck, and made diagnoses without hesitationor fear of being wrong. The scars on theback of my neck are the result of en­counters with reality.Our surgeons-in-chief were haughtyand pompous. When they spoke nursescowered, interns blanched, and even thewalls trembled. The heads of the twosurgical services at the PresbyterianHospital at that time had gotten theirtraining in Germany where the profes­sors, the great Geheimrats, were lords ofall they surveyed. Some of this attituderubbed off on the American students.My senior attending surgeon, a mostskilled and capable operator and a manwhom I greatly respected, spoke to meregularly during each operation. He al­ways used the same five words and thesame tone: "Get out of my way."At that time there were no real surgi­cal residencies as we know them today.So after twenty-one months of intern­ship I went out and did some generalpractice while trying to look like a sur­geon-stern and gruff and talking in agravelly tone.There is still another chapter in thisstory of what The University of Chicagodid for me. They gave me the LoganFellowship in surgery for two years at athousand dollars a year; it was quitedifferent from the fellowships of today.I worked part-time in the research labo­ratory, if such it could be called, on thefifth floor of the old Rush laboratorybuilding, taught students surgical anat­omy, and spent much time in the Cen­tral Free Dispensary. Late afternoonsand evenings I was in my office trying tobuild up a practice; two hours a weekwould have been more than enough. Atone point I had three regular patients.Then within one week one died, oneturned Christian Scientist, and the thirdwas cured of his urethral stricture. Istarted all over.I delivered five babies in the monthsbetween an appendectomy and a hemor­rhoidectomy. All five were L.O.A.'s. Istood by, said, "Well hello, baby," tiedthe cord, looked important and collecteda small fee. The fifth case-a cute littlewoman said she wanted a redheadedboy. Being brash, I promised her justthat. You know what? She gave birth toa redheaded boy, and truly I believe shethought I somehow had influenced theoutcome. At that point, with a perfectrecord, I decided to quit obstetrics andgo in for the treatment of upper respira­tory diseases-the only treatment thathasn't changed in forty years. You see,when you're a surgeon you have to beon the job at the time of a cold because you can never tell when it will turn intopneumonia and be followed by empyema-a strictly surgical disease.I had a number of old ladies who likedtheir blood pressure taken from time totime. That suited me fine. I could changeto a specialist in blood pressure readingsin nothing flat. A little old lady aboutseventy called me to her home becauseshe was nervous and thought her bloodpressure was up, It was high, 260 over130. Her urine was negative. She wasobviously apprehensive. I couldn't fiddlearound with polyunsaturated fats be­cause they hadn't been invented, and Icouldn't put her on a reducing diet be­cause she was skinny as a rail. So I gaveher a prescription concealed in my bestLatin for syrupi prunae virginanae­dram uno, tres in dies post eibum et noc,I was sure the druggist would interpretnoc as bedtime. Syrup of wild cherryspelled out in readable English wouldn'thave done her any good.You know, I went back a week laterand the patient felt fine. Her blood pres­sure had fallen to 170 over 90 mm ofHg. I felt a bit apologetic to the goddessof scientific medicine but not too quack­ish, because I recalled a well-known at­tending man at the Presbyterian Hos­pital who used to prescribe 3 grains ofsodium bromide in some foul-tasting li­quid for ill-defined complaints.Those were what we sometimes callthe good old days, but were they? Westood helplessly by when patients diedof peritonitis, pneumonia, or meningo­coccal meningitis. Acquired and congeni­tal heart disease were something thatadults and children lived with or quietlydied of while the doctor stood by andcomforted bereaved parents.We will skip over the next thirty-fiveyears, during which time antibioticswere discovered, physiological care wasintroduced, and the virgin fields ofthoracic and cardiac surgery wereopened. In view of the fact that a fewof the 1964 graduating class are here,let's take a look at medicine today andponder a question.The practice of medicine has changedfar beyond the wildest imagination ofthose who graduated in 1924. It seemsimpossible that equivalent changes willoccur in the next forty years, but I'msure they will for the simple reason thatstudents today are much smarter thanwe were.In this surge of progress and pressurefor more and more, here is a questionwhich requires some thought: how muchis enough? How much is enough of any­thing or everything?MEDICAL ALUMNI BULLETIN 5First, let's consider learning. A stu­dent's mind can assimilate only a limitednumber of facts and experiences duringthe long period of training. Sometimesit appears that time for comforting apatient with a hopelessly fibrillatingheart or for patting a homesick child onthe head is totally usurped by a coldscientific process of disease analysis.Recently, an eighty-year-old woman,a long-time friend and a patient of mygeneral practice days, went to one of thegreat hospitals in the city associatedwith a medical school for treatment ofdiabetes and some cardiac irregularity.While in the hospital, attended by aphysician and a retinue of interns andresidents, she was referred to-and un­fortunately heard the remark-as thediabetic-cardiac in Room 446. You knowwhat she did? She packed up and said,"I won't be just a diabetic-cardiac," andwent to a local community hospitalwhere her family doctor was on the staff.He prescribed a simple diet, some digi­talis, and didn't consider it necessary tohave daily electrocardiograms and fre­quent venous punctures for all sorts ofblood analyses. The doctor actually tooktime to sit down at her bedside, listen toher complaints, quiet her fears, andassure her that all would be well. Ofcourse she recovered.Last week a nurse in our outpatientdepartment at the Children's MemorialHospital heard a student hold forthabout an interesting case he had seen.She turned to him and heatedly said,"That child is not just an interestingcase. He is Camillo Valdez, a little boywith an interesting problem that you aretrying to solve."Second, how much is enough of re­search? The pat answer, "there is nosuch thing as enough," requires a littlethought. Medical journals are alreadybulging with reports of research workrepeated again and again. The urge topublish-publish or perish-drives medi­cal schools to endless applications forgrants to support the grinding out ofmore and more reports of research.Of course, research is essential. With­out it there is no hope, no chance ofprogressive medicine. But how much isenough? It seems to me that pontificalpronouncements about the importanceof having all medical students do someresearch is so much poppycock. Themajority of medical students haven't thetime, inclination, or ability to do re­search, and professors aren't smartenough to think up worthwhile researchprojects for the entire student body.Most students will profit far more from6 MEDICAL ALUMNI BULLETIN learning how to construct grammaticalsentences and mold them into a well­rounded paragraph than they will fromdrawing pictures of chromosomes or try­ing for the umpteenth time to grow ul­cers in dogs' stomachs.The lure of doing research, that is,sitting at a bench, smoking a pipe well­charred at one side from frequent light­ing over a Bunsen burner, and conjuringup rosy dreams of great discoveries,might well be supplanted by sitting at apatient's bedside, listening patiently andintelligently to the story of disease, ortalking with a mother who has justlearned that her child has leukemia.The biggest question and most difficultto answer is "how much is enoughmoney?" To that one I know the answer-exactly twice as much as you have to­day. But when should one cease to wishto double the amount? At exactly thattime-and not a moment later-whenmore seems of paramount importance.Whether one makes a modest living or alot of money in the practice of medicineis of relatively little importance. Theonly danger-and it is a deadly one­is that the love of money may becomepowerful enough to lead to unnecessaryoperations and to administration ofiron, vitamins, and what have you by in­jection three times weekly when a bottleof Geritol or a balanced meal would dojust as well. Observe and preach toyourselves from time to time a sermonon the corroding influence of moneymadness. Recognize and wipe away thefirst tiny stain of compromise with yourprinciples of honesty and fair dealing.One could go on indefinitely abouthow much is enough of many projects:of graduate training? I think a surgeonshould get through with it before he hashis first coronary. Of golf? Do youthink it a worthy ambition for a doctorto aspire to have written on his tomb­stone, "His Handicap was Two"? Ofliquor-not one, not three, but two, andthose only when the sun slips over thehorizon. Of fame? Well, wrap all awardsin a piece of brown paper, put them inthe lowest drawer of your desk, andleave them there. Of speech-making?There's already too much.So one last comment to the SeniorClass. As I look through the retrospect­o-scope I envy you all just beginningyour careers. Just this suggestion: Inthe training period ahead of you find aman whose every characteristic you ad­mire and make him your hero. Be your­self, but study the man and let thethreads of his character be woven intoyour pattern. Look for a Mr. Chips in medicine. You'll find such men in thehospitals in which you continue yourtraining. Watch them, copy them, followthem, catch their reflections and soonyou'll be emitting the same light butbrighter to those who follow you. Al­ways be yourself, to yourself be true,and let the practice of medicine be funbecause it's the most wonderful job inthe world.GURNEYMcCLINTOCK AWARDClifford Gurney, '51, was chosen bythe Class of 1964 to receive the McClin­tock Award for outstanding teaching. Dr.Gurney was a Markle Scholar from 1959to 1964 and he spent the year 1959-60 in England as Visiting Scientist atChurchill Hospital in Oxford. He is atpresent associate professor of medicineand chief of the hematology service witha joint appointment in physiology.SAN FRANCISCO MEETINGOne hundred and sixteen guests at­tended the dinner for medical alumni onJune 22 arrang-ed by the University ofChicago Club during the A.M.A. conven­tion in SanFrancisco. Hilger P. Jenkins,'27, provided a special welcome in theform of a short color film with greetingsfrom the Alumni Association by Presi­dent Emmet Bay, '23, and by formerpresidents Henry Ricketts, M. EdwardDavis, '22, and Walter Palmer, '21.A standing ovation was given to LesterR. Dragstedt, '21, the speaker of theevening. His talk was on "Christian Feng­er: The Father of Surgery in the MiddleWest."D.S.A.Konrad Emil Bloch, Faculty 1946-54,was presented for the DistinguishedService Award by Earl A. Evans, Jr.Born in Neisse, Germany, in 1912, Dr.Bloch received his first training in Ger­many and, coming to this country in1935, he received the Ph.D. degree in bio­chemistry in 1938 from Columbia Uni­versity. He remained there until 1946when he came to Chicago as assistantprofessor of biochemistry. He was pro­moted to full professorship in 1952 andleft in 1954 to become the Higgins pro­fessor in the Department of Chemistryat Harvard.He is a member and officer of manylearned societies including the NationalAcademy. His investigations have beenconcerned with the biosynthesis of lipidsand steroids.Matthew Harold Block, Ph.D. '41,M.D. '43, was presented by his formerteacher of anatomy, William Bloom. Dr.Block interned here and was a memberof our faculty in medicine from 1947 to1953. He is now Harlow Professor ofMedicine at the University of Colorado.In presenting him Dr. Bloom recalled histhesis on yolk-sac transplants, the begin­ning of investigations which would cul­minate in a long and important series ofpublications on blood formation in manin health and disease and in experimentson animals. "You have shown unusualmental and physical stamina and couragein tackling especially difficult experi­ments. Your curiosity is as intense asever, as is your drive to satisfy it. ...It has been one of the great rewardsof my life to watch your developmentsince we first met twenty-six years ago,to see you attain eminence in your chosenfields of endeavor. In short, Matthew,I am proud to have been your teacher."Edward L. Compere, '27, was pre­sented by Albert M. Potts. Dr. Comperetrained in orthopedic surgery under Dal­las B. Phemister and was a member ofour faculty in surgery from 1928 to 1940.He is now professor and chairman of theDepartment of Orthopedic Surgery atNorthwestern and chairman of the De­partment at Chicago Wesley MemorialHospital. Dr. Compere was for thirteenyears editor of the Yearbook of Ortho­pedic and Traumatic Surgery, and he haspublished research on the metabolismof calcium and phosphorus, infantile pa­ralysis, tuberculosis of bones and joints,and the physiology and pathology of thespine. 1914 class: BEYER, BRERETON, BRIDENBAUGH, CHRISTIE, CRAFTS, CURRY,EDMONDS, FISHER, JONES, KUBIK, LAWSON, McCULLOUGH, WELLS, andWHARTON. (WISE not in this picture.)THE CLASS OF 1914This spring twenty-two of the thirty­two living members of the Class of 1914answered our request for information ontheir careers and current interests.Almost half of the members of theclass continue to spend at least a part oftheir "golden years" in practice or teach­ing. Many can count children or grand­children among their colleagues; JohnBridenbaugh, for instance, who is theoldest practicing radiologist in Montana,has a radiologist son and a grandsonin medical school.Their avocations include agriculture,fishing, photography and travel. RussellWharton and his wife have visited Mexi­co, seven provinces of Canada, and everystate of the Union except Hawaii.Age does not seem to have diminishedthe energy and enthusiasm of these menand women. For the sake of those young­er people to whom they must be a greatexample and encouragement, we aregrateful that so many were able to bewith us on June 12.Testimonials were presented to:Arthur G. Beyer, otolaryngologist ofCincinnati;Harold L. Brereton, general practi­tioner and general surgeon of Emmets­burg, Iowa;John Bridenbaugh, campus doctor atRocky Mountain College and radiologistin Billings, Montana;Roy E. Christie, now part-time ci­vilian physician at Defense General Sup­ply Center in Richmond, Virginia;Earl Crafts, now retired in Lima, Ohio;Louis T. Curry, emeritus in otolaryn­gology at Presbyterian-St. Luke's Hos­pital since 1962;Devilla D. Edmonds, retired fromgeneral practice in Kansas City, Missourisince March of this year; Lawrence F. Fisher, radiologist ofSouth Bend, Indiana;Richard N. Jones, general surgeonand general practitioner of St. Cloud,Minnesota;Charles S. Kubik, neurologist on theattending staff of Massachusetts GeneralHospital;Gustave W. Lawson, in private prac­tice of internal medicine in Chicago;Clifford McCullough, general surgeonand general practitioner in Riverside,California;S. Merrill Wells, retired from thepractice of internal medicine in GrandRapids, Michigan;Russell O. Wharton, general practi­tioner of Gary, Indiana;Earl De Witt Wise, in private prac­tice of obstetrics and gynecology inChampaign, Illinois.Testimonials were sent to:Milford E. Barnes, Iowa City, Iowa;Carl C. Birkelo, Winter Park, Florida;Robert L. Bowen, Hibbing, Minne-sota;Gilbert E. Brereton, Dallas, Texas;William F. Brinkman, Pocahontas,Iowa;Emil Bunta, Chicago;Lowell M. Campbell, Minneapolis;Hayes H. Culbertson, MountainHome, Arkansas;Jacob R. Harry, Chicago;Russell M. Johnson, Chicago;Gerard N. Krost, West Salem, Wis-consin;Robert H. Lowry, San Antonio,Texas;Frank B. Lusk, Chicago;Alexander MacDonald, Valley City,North Dakota;Warren M. Miller, St. Petersburg,Florida;Peter A. Nestos, Santa Barbara, Cali­fornia;Henderina Van de Erve, Los Angeles.MEDICAL ALUMNI BULLETIN 7HANKEGOLD KEYMartin Hank�, Ph.D. '21, ProfessorEmeritus of Biochemistry, was presentedby Ray Koppelman, Ph.D. '52. Dr.Hanke was a member of the Departmentof Biochemistry from 1922 until 1955,when he went to Egypt to head the De­partment of Biochemistry in the U.S.Medical Research Unit in Cairo. Forcedto leave that troubled country in 1956,he returned to Billings to direct the Clin­ical Chemistry Laboratory until his re­tirement in 1964. A vivid tribute to Dr.Hanke given by Allan Kenyon, '25, at atestimonial dinner on the occasion of hisretirement appears on page 20. Heinrich Kluver, Sewell L. AveryDistinguished Service Professor Emeri­tus, was presented by Richard B. Rich­ter, '24:"Our Committee on Awards this yearhas done itself proud. Professor Kliiver,as you all know, is one of the world'sforemost theoretical and physiologicalpsychologists, best known, perhaps, forhis experimental work on animal behav­ior. Although he has had a long and dis­tinguished career in this University, onemight ask, at first thought, why a scien­tist in this field should be singled outfor the highest award conferred by thealumni of a medical school. Well, Profes­sor Kliiver has always been the despairof academic taxonomists. He defies clas­sification and refuses to be circumscribed.He occupies a scholar's tower, to be sure;but it is not the ivory one of a super­specialist. His knowledge is of extraordi­nary breadth and one can safely say thathe is the closest approach to the universalscholar that can be found nowadays.Consequently, much of his work has hada very direct impact on medicine in gen­eral and especially upon neurology andpsychiatry, although the only things hehas in common with Freud are a birthdayin May and the fact that he is probablythe only man in the world who remem- .bers Freud's telephone number."His analysis of the Kliiver-Bucy syn­drome has had an important influenceon thinking in neurological and psychi­atric clinics and upon neurosurgical ther- KLUVERapy everywhere. His studies on porphy­rins in the nervous system is of greatinterest to clinicians, biochemists andphysiologists. As a by-product of thiswork he has devised a histologic stainingtechnique which has greatly facilitatedthe work in laboratories of neuropathol­ogy the world over. The early monographon mescaline, published in 1928, makeshim, in a sense, the father of modempsycho-pharmacology."These are a few of the reasons whyI have the privilege of presenting to Pro­fessor Kluver, on behalf of the AlumniAssociation of the School of Medicineof The University of Chicago, this GoldKey."SENIOR HONORS ANDAWARDSFive members of the Class of 1964were graduated with honors. They were:J ames Castles, David Gross, LawrenceKass, James Winebright, and RobertZelis.Robert Zelis won the Borden Awardfor his paper on "Incorporation ofPhenylalanine into Polypeptide Linkageby Microsomes From Regenerating RatLiver." Work on this study was done inthe Ben May Laboratory.The Medical Alumni Prize for excel­lence in the presentation of a paper atthe Senior Scientific Session was award­ed to Bruce Bolasny, who delivered areport on "Localization of 3-Methylchol­anthrene in Mammary Tissue."8 MEDICAL ALUMNI BULLETIN This year three of the ten Sheard­Sanford Awards given nationally by theAmerican Society of Clinical Patholo­gists went to members of the graduatingclass. Those honored were: Alan P.Braun, for his paper on "The Produc­tion of Glucagon Antibodies in theGuinea Pig"; Abdollah Sadeghi-Nejad,for his paper on "MitochondrialChanges Induced by Phenergan in theProximal Tubular Cells of Rat Kidney";and James W. Winebright, who wroteon "The Agglutinin Response to Partic­ulate and Soluble Forms of FlagellarProtein from Salmonella Typhosa:"Alan P. Braun also won third place inthe Student American Medical Associa­tion-Mead Johnson competition.James Castles was awarded the BarryGinsburg Memorial Prize in physiologyfor 1963-64. Robert Pierce was chosen by his class­mates to make the speech for the Seniorsat the Banquet.THE SENIOR CLASS OF J964AARON, BARUCH MICHAELBorn May 15, 1939; U. of Michigan, B.A., 1960;Intern.: Mt. Sinai H., Chicago; Dermatology; Un­married; 1537 Juneway Terr., Chicago 26.ANDERSON, CLARK. LAWRENCEBorn Nov. 9,1937; U. of Arizona, B.A., 1960; work­ing toward PhD. in biochemistry, U. of Chicago; In­ternal Medicine; Married; 5482 University, Chicago;203 Newcastle Drive, San Antonio, Tex.ANTICO, DOMINIC ANTHONYBorn Feb. 13, 1940; Washington & Jefferson College,B.A., 1960; Intern.: Parkland Mem. H., Dallas, Tex.;Internal Medicine; Married; One child; 828 OhioAve., Glassport, Pa.BERNSTEIN, MARVIN JAYBorn Sept. 24, 1939; I.I.T., B.S., 1960; Intern.: LosAngeles Co. H.; Medicine; Unmarried; 5905 N. St.Louis, Chicago.BOLASNY, BRUCE LYNNBorn Aug. 19, 1939; U. of Florida, B.S., 1961;Intern.: Billings; General Surgery; Married; 612 High­land Drive, Hollywood, Fla.BORMAN, JOHN DAVIDBorn Nov. 28, 1939; Augustana College, S.D., B.A.,1960; Intern.: Ben Taub Gen. H., Houston, Tex.;Internal Medicine; Unmarried.BRA TH, WILLIAM FRANKBorn Nov. 26,1938; Walla Walla College, B.A., 1960;Intern.: Palo Alto-Stanford H. Center, Palo Alto,Calif.; Pediatrics; Married; 1030 N.E. 153rd, Port­land 30, Ore.BRAUN, ALAN PETERBorn May 22, 1938; Franklin & Marshall College,B.S., 1960; U. of Chicago, M.S., 1964; Intern.: Monte­fiore H., N.Y .C., Internal Medicine-Endocrinology;Unmarried; 224 State St., Perth Amboy, N.J.BRODY, EDWARD NORMANBorn Mar. 2,1939; Roosevelt U., B.S., 1959; work­ing toward Ph.D. in biochemistry, U. of Chicago;Undecided; Unmarried; 5543 Kimbark Ave., Chicago;5429 N. Campbell Ave., Chicago.BUTTERFIELD, THOMAS KENTBorn June 4, 1933; Phoenix College, A.A., 1953;Brigham Young U., B.S., 1957; Intern.: Maricopa Co.Gen. H., Phoenix, Ariz.; Internal Medicine; Married;One child; 674 S. York, Denver, Colo.CASTLES, JAMES JOSEPH, JR.Born Oct. 3, 1940; U. of Chicago, B.S., 1961; In­tern.: Presbyterian H., N.Y .C. ; Internal Medicine;Married; One child; A.O.A. 1963; 38 S. 5th Ave.,Highland Park, N.J.CHAN, KEE NAMBorn Feb. 4, 1934; Coe College, B.A., 1960; Intern.:St. Paul's H., Vancouver, B.C., Canada; Undecided;Married; c/o Chew Bros., 1601 Lonsdale Ave., NorthVancouver, B.C., Canada; 4, Somerset Rd., Kowloon,Hong Kong.CHAVINSON, MELVIN JAYBorn Dec. 15, 1938; Kenyon College, B.A., 1960;Intern.: Colorado Gen. H., Denver; Child Psychiatry;Married; 23530 Bryden Road, Beachwood 22, Ohio.COLEMAN, LEE STUARTBorn Oct. 12, 1938; Occidental College, B.A., 1960;Intern.: Childrens H. of Los Angeles; Child Psychi­atry; Unmarried; c/o Hilda Coina, 1222 Mersey Ave.,San Leandro, Calif.COOPER, CHARLES LEONARDBorn June 5, 1939; Augustana College, B.A., 1960;Intern.: Bobs Roberts; Pediatrics; Married; 5400Harper, Chicago; 476 46th St., Brooklyn 20, N.Y.MEDICAL ALUMNI BULLETIN 9THE SENIOR10 M E Die A L A L U M NIB U L LET I N COSTARELLA, ROBERT JOHNBorn July 22, 1935; U.C.L.A., A.A., 1956, B.A.,1957, M.A., 1960; Intern.: U. of Cal. H., The MedicalCenter, Los Angeles; General Surgery; Married; 48N. Darcy Ave., San Mateo, Calif.CSONTOS, MARY ANN TERESABorn Oct. 15, 1938; Hiram College, B.A., 1960;Intern.: U. of Mich. H., Ann Arbor; Pediatrics; Un­married; 4333 W. 23rd St., Cleveland 9, Ohio.DRESSLER, DAVID MICHAELBorn May 9, 1939; Reed College, B.A., 1960; In­tern.: San Francisco Gen. H.; Psychiatry; Unmarried;481 Woodlawn Ave., Glencoe, Ill.ELLENBOGEN, CHARLESBorn Feb. 10, 1939; U. of Chicago, as, 1960;Intern.: Wilford Hall, U.S.A.F. H., Lackland A.F.B.,Tex.; Internal Medicine; Unmarried; 4509 E. CastleDrive, McGuire A.F.B., N.J.ENGLUND, STANLEY ALLANBorn Aug. 30, 1938; I.I.T., B.S., 1960; Intern.:U.S. Navy H., Oakland, Calif.; Psychiatry; Unmar­ried; A.O.A.; 11309 S. St. Louis, Chicago.FIXLER, DAVID ELLSWORTHBorn April 26,1938; U. of Notre Dame, B.S., 1960;Intern.: Childrens Mem. H., Chicago; Pediatrics;Married; A.O.A.; 816 E. 58th St., Chicago; 2819Southridge Drive, South Bend 14, Ind.GARFIELD, JOSEPH MICHAELBorn Oct. 5, 1938; Earlham College, B.A., 1960;Intern.: H. of U. of Pa., Phila.; Anesthesiology; Un­married; Apt. 246, School Lane House, Phila. 44.GERWIN, ROBERT DAVIDBorn June 30, 1938; U. of Chicago, B.S., 1960;Intern.: Bellevue H. Center, N.Y.C.; Neurology;Married; 6840 Cregier Ave., Chicago 49.GILLETTE, PETER NARCISSEBorn Oct. 26, 1932; Intern.: Billings; Internal Medi­cine; Married; 910 E. 57th St.; 2680 W. 80th Ave.,Denver 21, Colo.GRONEW ALD, WILLIAM ROBERTBorn Jan. 21, 1939; Earlham College, B.A., 1960;Intern.: Ben Taub Gen. H., Houston, Tex.; Unmar­ried; 10220 Capital View Ave., Silver Spring, Md.GROSS, DAVID MOSSBorn Dec. 10, 1938; Harvard, B.A., 1960; Intern.:Billings; Urology; Unmarried; A.O.A.; 7722 S. Jeffrey,Chicago; 10300 Lakeshore Blvd., Cleveland 8, Ohio.HAMMATT, ROBERT WAYNEBorn Dec. 23, 1941; U. of Chicago, B.S., 1960;Intern.: Southern Pacific Gen. H., San Francisco;Orthopedics; Unmarried; 3631 Prairie Ave .. Brook­field, Ill.HAMMERSTAD, JOHN PHILIPBorn Jan. 26, 1938; Stanford U., B.A., 1960; Intern.:Palo Alto-Stanford H. Center, Palo Alto, Calif.; In­ternal Medicine; Married; One child; A.O.A.; BayouShore Apts., #61, 1400 Bayou Shore Drive, Galveston,Tex.HENRY, LLOYD NASIBUBorn July 11, 1937; U. of Chicago, B.S., 1961;Intern.: Cook County H.; General Surgery; Unmar­ried; Box 55, Christiansted, St. Croix, Virgin Islands.HERRICK, ROBERT RAPHAELBorn May 21, 1938; Oberlin College, B.A., 1960;Intern.: King County H., Seattle; Internal Medicine;Married; One child; 6942 Pennsylvania Ave., Pitts­burgh.CLASS OF J 964HESSL, JOHN MARTINBorn May 29, 1938; Carleton College, B.A., 1960;Intern.: Minneapolis Gen. H.; Surgery; Unmarried;83 Groveland Ave., Riverside, Ill.HILL, DA VID LLEWELLYNBorn Nov. 22, 1938; Augustana College, RockIsland, Ill., B.A., 1960; Intern.: Minneapolis Gen. H.;Surgery; Married; One child; 3909 8th Ave., RockIsland, TILHIRASA, JAMES HARUOBorn Feb. 27, 1934; U. of Chicago, B.S., 1960;Intern.: Los Angeles Co. Harbor Gen. H., Torrance,Calif.; Undecided; Unmarried; A.O.A.; 1208 KaalaSt., Wahiawa, Oahu, Hawaii.HIRSCHFELD, ARTHUR JAMESBorn Aug. 10, 1938; U. of Notre Dame, B.S., 1960;Intern.: Palo Alto-Stanford H. Center, Palo Alto,Calif.; Pediatrics; Unmarried; A.O.A. 1963; 1106Country Lane, Champaign, Ill.HOELL, NOEL LARAMIEBorn July 31,1939; Intern.: U. of Oregon MedicalSchool Hospital, Portland; Psychiatry; Unmarried;Box 353, Helena, Mont.HULL, JAMES DIXON, IIIBorn July 10, 1939; Earlham College, B.A., 1960;Intern.: Pennsylvania H., Phila.; Surgery ; Unmarried;141 E. Central Ave., Moorestown, N.J.JAMES, NORMAN JOHNBorn Nov. 25, 1938; Lawrence College, B.A., 1960;Intern.: University Hospitals, Madison, Wisc.; In­ternal Medicine; Married; 3366 N. 92nd St., Mil­waukee 22, Wisc.JUST, JOSEPH FRANKBorn Mar. 11, 1935; Intern.: Cook Co. H.; GeneralPractice; Unmarried; A.O.A.; 2112 S. Clarence Ave.,Berwyn, Ill.KASS, LAWRENCEBorn Sept. 30, 1938; U. of Michigan, B.A., 1960;Intern.: Peter Bent Brigham H., Boston; InternalMedicine-Hematology; Unmarried; A.O.A. 1963 ;3229 Streatham Court, Toledo 15, Ohio.LAMB, JOHN WILLIAMBorn July 15, 1937; U. of Chicago, B.S., 1959;Intern.: Kings Co. H. Center, Brooklyn, N.Y.; Gen­eral Surgery; Unmarried; Route 2, Clinton, NorthCarolina.LENN, NICHOLAS JOSEPHBorn Nov. 26, 1938; U. of Chicago, B.S., 1959, M.S.,1964; research associate at National Institutes ofHealth, Bethesda, Md.; Neurology; Unmarried; 5500South Shore Drive, Chicago 37.LEVINE, BARRY STEVENBorn Oct. 6, 1938; Dartmouth College, B.A., 1960;Intern.: Mt. Sinai H., N.Y.C.; General Surgery; Un­married; 12-02 12th St., Fair Lawn, N.J.PALOY AN, DANIELBorn Nov. 25, 1939; U. of Chicago, B.A., 1961;Intern.: Billings; Surgery; Married; 4917 W. Kirk,Skokie, Ill.; 9506 Lorel, Skokie.PIERCE, ROBERT HAMILTONBorn Oct. 6, 1938; U. of Idaho, B.S., 1960; Intern.:U.S.P.H.S. H., Boston; Undecided; Married; Onechild; 931 7th Ave., Lewiston, Idaho.PLZAK, GEORGE JOHNBorn Dec. 14, 1940; U. of Chicago, B.S., 1959;Intern.: Highland-Alameda Co. H., Oakland, Calif.;General Practice; Married; 80th Ave. and 131st St.,Palos Park, Ill.MEDICAL ALUMNI BULLETIN 11THE SENIOR12 ME Die A L A L U M NIB U L LET I N RADA, RICHARD THOMASBorn Mar. 20, 1938; Concordia Sr. College, B.A.,1959; Intern.: Blodgett Mem. H., Grand Rapids,Mich.; Psychiatry; Married; One child; 2247 N. 71stSt., Wauwatosa, Wisc.RANSIl, BERNARD JEROMEBorn Nov. 15, 1929; Duquesne U., B.S., 1951;Catholic U. of America, Ph.D., 1955; Intern.: LosAngeles Co. Harbor Gen. H., Torrance, Calif.; Aca­demic Medicine; Unmarried.REITAN, JOHN ARTHUR B.Born Nov. 2, 1936; Carleton College, B.A., 1958;Intern.: Maricopa Co. Gen. H., Phoenix, Ariz.; Ortho­pedics; Unmarried; 5436 Brookview, Minneapolis 24,Minn.RHYNEER, GEORGE SAMUELBorn June 1, 1938; U. of Washington, B.S., 1960;Intern.: Billings; Internal Medicine; Married; Onechild; 1917 Howell, Richland, Wash.ROSKOSKI, ROBERT, JR.Born Dec. 10, 1939; Bowling Green State U., B.S.,1961; graduate student in biochemistry, U. of Chicago;Undecided; Unmarried; 5532 Kenwood, Chicago; 234Courtland St., Elyria, Ohio.SADEGHI-NEJAD, ABDOllAHBorn April 29, 1938; Beloit College, B.A., 1960;U. of Chicago, M.S., 1964; Intern.: Billings; Pedi­atrics; Unmarried; 5532 Kenwood, Chicago; Ave.Farah, Tehran, Iran.SAMUELSON, GENE HOWARDBorn Aug. 12, 1929; U. of Arizona, B.A., 1951, M.S.,1951;. Pacific Lutheran Theological Seminary, B.D.,1954; Intern.: Billings; Neurosurgery; Married; Fivechildren; 1049 Keystone Ave., Northbrook, Ill.SCHOENFELD, FREDERICK GEORGEBorn Sept. 12, 1938; U. of Chicago, B.S., 1960;Intern.: Billings; Surgery; Unmarried; 5305 W. New­port Ave., Chicago.SCHOPF, CARRIE KREWSONBorn July 3, 1938; Vassar College, B.A., 1960;Intern.: St. Elizabeth's H., Boston; Pediatrics; Mar­ried; c/o T. J. M. Schopf, Marine Biological Lab­oratories, Woods Hole, Mass.; 1427 Clarence Ave.,Lakewood 7, Ohio.SEIDEN, ANNE MAXWELLBorn May 22, 1936; U. of Chicago, B.A., 1959;Intern.: San Francisco Gen. H.; Psychiatry; Married;142 Pinecrest Rd., Durham, N.C.SHAIKUN, GERALD lEEBorn Jan. 11, 1940; U. of Kentucky, B.S., 1960;Intern.: Jewish H., St. Louis, Mo.; Medicine; Mar­ried; 2330 Brighton Dr., Louisville, Ky.SPONSLER, JOHN ANTHONYBorn July 17,1938; U. of Calif. at Berkeley, B.A.,1960; Intern.: Blodgett Mem. H., Grand Rapids,Mich.; Psychiatry; Unmarried; 647 Fernwood Dr.,Salem, Va., 24153.STRAUSS, RICHARD HARRYBorn July 30, 1938; Michigan State U., B.A., 1960;Intern.: Billings; Internal Medicine; Unmarried; 506Princeton Pl., San Luis Obispo, Calif.TAYLOR, ROBERT SHANKSBorn Aug. 14, 1934; U. of Idaho, B.S., 1960; Intern.:Mound Park H., St. Petersburg, Fla.; Undecided;Married; One child; Rt. 6, Box 355A, Olympia, Wash.WEIS, THEODORE PATRICKBorn Aug. 16, 1936; U. of Wisc., B.S., 1958; Intern.:Billings; Internal Medicine; Married; One child; 7608S. Chappel, Chicago.CLASS OF J964WINE BRIGHT, JAMES WILLIAMBorn Sept. 9, 1936; Knox College, B.A., 1958; U. ofChicago, M.S., 1962; Intern.: U. of Washington H.,Seattle; Internal Medicine; Unmarried; A.O.A.;Smithshire, Ill. (R.F.D.).WITTENSTROM, EUGENE CARLBorn June 16, 1938; Augustana College, Ill., B.A.,1960; Intern.: U. of Ill. Res. and Educ. H., Chicago;Orthopedic Surgery; Unmarried; 941 Elma Ave.,Elgin, Ill.ZELIS, ROBERT FELIXBorn Aug. 5,1939; U. of Mass., B.S., 1960; Intern.:Beth Israel H., Boston; Medicine; Married; Twochildren; A.O.A.; 96 Montgomery St., Chicopee Falls,Mass.SENIOR SCIENTIFIC SESSIONLocalization of 3-Methylchol­anthrene in Mammary TissueBy BRUCE BOLASNYSurgery3-methylcholanthrene (3-MC) be­comes localized predominantly in themammary glands and other fatty tissuesfollowing feeding to female rats. A singlefeeding of a large dose of 3-MC rapidlyinduces mammary carcinoma. Variationin the endocrine state of animals pro­foundly alters the frequency of mam­mary cancer produced by this method.The amounts of 3-MC present in ratmammary glands after feeding were de­termined by spectrophotofiuorometricanalysis of benzene extracts of the tis­sue. The concentration of 3-MC in themammary tissue twenty-four hours afterfeeding increased in direct proportion tothe quantity fed. 3-MC was detectablein the mammary glands for fifteen daysafter a single 50 mg feeding. The result­ing occurrence of mammary cancer cor­related closely with both the dosage andthe tissue concentration of 3-MC.The intramuscular administration ofestradiol valerate concurrent with 3-MCfeeding greatly reduced the incidence ofmammary carcinoma. It did not, how­ever, alter the uptake or clearance ofthe carcinogen by the mammary tissue.Thus, the suppression of mammary can­cer induction by exogenous estradiol can­not be explained by altered levels of 3-MC in the mammary glands. The uptakeand clearance of 3-MC by the mam­mary gland were independent of thehormonal factors studied in this experi­ment. Metabolism of Radiomolyb­denum in ManBy WILLIAM F. BRATHMedicineMolybdenum appears to be an essen­tial nutrient of animals. It has beendemonstrated to be an integral part ofthe enzyme, xanthine oxidase. As littlehas been known of the metabolism ofmolybdenum in man, the reported studieswere carried out using M099 as a radio­active tracer.Orally administered M099, as ammo­nium molybdate, was rapidly and almostcompletely absorbed from the gastro­intestinal tract. The metabolism of theradioisotope was similar following eitherintravenous or oral administration. Car­rier-free M099 disappeared quickly fromthe circulation, decreasing to less than0.3 per cent of the initial amount withinsix hours. It was taken up by the liverand to a lesser degree by the kidneysand the adrenals. The clearance of M099from the plasma by the kidneys wasapproximately 75 ml per minute. Thebiological half-life of molybdenum in sixnormal subjects, as determined by whole­body counting, was approximately eight­een days. Administration of supraphysio­logical doses of molybdenum was fol­lowed by rapid excretion, indicating lim­ited body storage of the element. Themain pathway of M099 excretion, fol­lowing either intravenous or oral admin­istration, was via the kidneys, the uri­nary to fecal excretion ratio being aboutfifteen to one. M099 proved to be useful in scintilla­tion scanning of the liver for the dem­onstration of tumors, abscesses, andother large lesions which destroy or dis­place hepatic parenchyma.The subcellular distribution of M099in rat liver and the specific activity ofM099 in xanthine oxidase with lime maybe interpreted as indicating uptake ofMoo9 by the microsomal fraction withsubsequent release to the non-micro­somal supernatant in the form of xan­thine oxidase.The Preparation, Potency andSpecificity of Guinea Pig Anti­Glucagon and Its Effect on Car­bohydrate and Lipid Metabo-lism in the RatBy ALAN P. BRAUNPathologyThe role of the alpha cell of the isletsof Langerhans in carbohydrate and lipidmetabolism is not completely defined.Glucagon, the secretory product of thiscell, increases blood sugar through itsaction on the liver. However, it is notclear whether this hormone alters lipidmetabolism.Recent advances in immunology pro­vided a method for preparing antibodyto glucagon. Potent anti-glucagon (AGS)was formed rapidly in guinea pigs bymultiple injections of crystalline beef­pork glucagon. The guinea pig serumwas analyzed for antibody by the tech-MEDICAL ALUMNI BULLETIN 13niques of radiochromatoelectrophoresisand radioimmunoelectrophoresis. Thegamma-globulin thus produced was spe­cific for glucagon and did not cross-reactwith insulin. The prepared AGS was ad­ministered to rats inducing hypogluca­gonemia. Groups of rats were force-fedeither a controlled diet rich in lipid andcarbohydrate but low in protein, or adiet which was rich in lipid and proteinbut low in carbohydrate. Blood sampleswere drawn in order to determinecbanges in blood sugar and lipids. At theconclusion of each experiment, the ani­mals were killed and pancreas, liver,heart, and kidney tissues were examinedhistologically.In general, the results indicated thatimmunological hypoglucagonemia wasassociated with hypoglycemia and hyper­lipidemia, first noticeable within fivehours after AGS administration.Histologically, there was degranula­tion, coarse smudging of the cytoplas­mic granules, and focal death of alphacells with nuclear debris seen at six­teen hours after a single injection ofAGS. With repeated administration ofAGS, reactive hyperplasia of alpha cellswas present. There was no evidence ofbeta cell damage or pathologic changein the liver, kidney, or heart.H is thought that anti-glucagon serumbinds circulating glucagon so that thealpha cells are stimulated to produce atincreased rates with eventual exhaus­tion and death of some of the cellsaccompanied by a reactive hyperplasiaof others.Infectious DNA from T7 andLambda Bacterial VirusesBy EDWARD BRODYBiochemistryDNA prepared by phenol extractionof T7 bacteriophage was found to beinfectious for lysozyme-EDTA sphero­plasts prepared from E. coli B, E. coli3350).., and E. coli 3350).., 7 (this laststrain being resistant to attack by intactT7). Heating this DNA to sub-meltingtemperatures increased the infectivitythree- to eight-fold, whereas heatingabove the melting temperature destroyedinfectivity. Heat-denatured T7 DNAdid not regain its infectivity when an­nealed, although hypochromicity was re­covered. This was in marked contrast tothe case of heat-denatured LambdaDNA where annealing restored bothhypochromicity and infectivity. LambdaDNA was found to have some proper­ties in common with T7 DNA; thesewere: 1) increase of infectivity on short14 MEDICAL ALUMNI BULLETIN heating times at 100 C or longer heatingtimes at sub-melting temperatures, and2) ability to infect spheroplasts of nor­mally resistant host strains. The increasein infectivity on heating to sub-meltingtemperatures was probably due to de­aggregation and/or partial denaturationof the DNA, facilitating its entry intothe spheroplast. The difference betweenheat-denatured T7 and Lambda DNAon annealing may be related to the num­ber of single-strand breaks in each DNAsample.Insulin, Amino Acid Transportand Protein SynthesisBy JAMES J. CASTLESPhysiologyI) The influence of puromycin--Incircumstances similar to that in which itincreases the incorporation of labeledamino acid into protein of isolated ratdiaphragm, insulin also enhances the ac­cumulation of certain, but not all, aminoacids. The tacit assumption has alwaysbeen made that the amount of aminoacid incorporated into protein is only asmall fraction of that added to the me­dium, and may, therefore, safely be ig­nored. Clearly, this assumption neededtesting. In the presence of sufficient pu­romycin to suppress protein synthesis,insulin increased accumulation of aminoacids ordinarily not responsive to thehormone. Apparently, in the presence ofinsulin, the increase in the rate of incor­poration into protein of most, but notall, amino acids, is sufficient to preventtheir accumulation to a level greaterthan that which occurs in the absence ofthe hormone, even when transport toois stimulated.II) The effect of alloxan diabetes-Itremains an important unresolved prob­lem whether amino acid transport canever be the site of effective biologicalregulation of protein synthesis in muscle;the possibility does exist, for all cellsmust solve that objective problem. Ifregulation of protein synthesis is exertedat the transport step, then amino acidaccumulation in muscle should be de­creased by diabetes for protein synthesisis. But, in point of fact, just the contrarywas found, namely, that insulin deficien­cy caused an increase in the transportinto muscle of radioactivity from amino­isobutyric acid and proline and, at oneand the same time, a decrease in incor­poration of amino acid into protein. Thefindings are inconsistent with the theorythat insulin modulates protein synthesisby an influence on amino acid transport; they are in accord with the idea that theprimary site of insulin action is at apoint distal to the transport process.Isoenzymes of AlkalinePhosphataseBy KEE NAM CHANMedicineSerum alkaline phosphatase is knownto be elevated in various diseases, espe­cially those involving the hepato-biliaryand osseous systems. The present studywas undertaken to identify the charac­teristic electrophoretic patterns of iso­enzymes of serum alkaline phosphatasein health and disease and to correlatethese patterns 'with those found in se­lected tissues.Serum samples from thirty-five nor­mal subjects and fifty-five patients werestudied. Also, crude extracts of alkalinephosphatase were prepared from vari­ous human tissues at autopsy. The ac­tivity of alkaline phosphatase was deter­mined by the phenolphthalein methodand vertical starch gel electrophoresiswas performed on all samples. At com­pletion of electrophoresis, one part ofthe gel was stained for alkaline phospha­tase. The other part of the gel wasstained with amido-black 10 B for serumproteins. Loci of alkaline phosphataseactivity were compared with their cor­responding serum protein bands andwith those of tissue extracts for identi­fication of their probable origins.Six electrophoretically different bandsof serum alkaline phosphatase were ob­served. These six bands could be groupedinto four characteristic patterns. Onewas found in healthy adults; anotherwas found in healthy children and inpatients with diseases characterized byincreased osteoblastic activity; a thirdwas seen in association with obstructiveintra- or extrahepatic disorders; and afourth with parenchymal hepatic dis­eases.Analyses of liver, bile, stomach, je­junum, ileum, colon, kidney, and lungdemonstrated a total of eight differentloci of alkaline phosphatase activity.Two of these bands were never seen inthe serum samples studied. The othersix were in loci identical with thosefound in the various serum samples. Allof these tissues had two to four of thesesix loci in common, and therefore in nocase did these tissues demonstrate aunique pattern of isoenzymes, whichwould permit precise localization of theorigin of isoenzymes appearing in theserum in association with disease.It is concluded that characteristicelectrophoretic patterns could be dis­tinguished between disorders affectingthe hepato-biliary and osseous systems.Furthermore, obstructive and parenchy­mal liver diseases could usually be dis­tinguished from each other. The pictureof increased osteoblastic activity asso­ciated with a variety of diseases couldnot be differentiated from the patternfound in normal children. No uniquetissue origins of isoenzymes of serumalkaline phosphatase could be demon­strated.Studies on the Uptake and Dis­tribution of MethoxyfluraneinManBy JOSEPH M. GARFIELDAnesthesiologyMethoxyflurane, a new inhalation an­esthetic, possesses several unique prop­erties, including: 1) a very low vaporpressure; 2) non-flammability; 3) ananesthetic potency greater than that ofany other inhalation agent known; 4)prolonged induction, emergence and re­covery times from surgical anesthesia.Laboratory studies were focused onthe solubility of methoxyflurane, sinceinduction times for volatile anestheticagents highly soluble in blood are longerthan those for relatively insoluble gas­eous agents, VVe found methoxyfluraneto be highly soluble in blood, possessinga blood-air partition coefficient of 13.2,and a water-air coefficient of 4.5 at 37 C.Pilot studies were performed withdogs, in which inspired and end-expiredconcentrations of methoxyflurane weremonitored and analyzed by gas chroma­tography.Similar studies were then performedon patients at operation. Arterial and, inone instance, cerebrospinal fluid samplesfor methoxyflurane levels were also ob­tained.The experiments yielded a series ofgas concentration curves, each repre­senting a multi-exponential series ofprocesses, each with its own time rate ofchange. These included: 1) uptake ofmethoxyflurane in the non-rebreathingsystem; 2) "wash-in" time; 3) lung ca­pacities and alveolar ventilation; 4) sol­ubility of methoxyflurane in the trachealmucous membrane; 5) cardiac output,lung perfusion and shunting at the alve­olar level; 6) diffusion of methoxyflu­rane across the alveolo-capillary mem­brane; 7) blood flow to the various tis­sues; 8) solubility of drug in the tissues.The inspired concentrations at the en­dotracheal tube reached 63 per cent of those delivered from the machine inabout 120 minutes, as compared to pre­dicted values of about 82 per cent. End­expired concentrations remained wellbelow inspired levels, reflecting the inter­play of solubility and lung factors. Ar­terial concentrations exceeded alveolarlevels.The lengthy emergence times appearedrelated to several factors. The most im­portant may be the large storage of an­esthetic in the aqueous tissue compart­ment, which may receive as much as30 per cent of the cardiac output.The body's fat depots may hastenemergence time, paradoxically, becausethey are so poorly perfused, receivingonly about 4 per cent of the cardiac out­put, even though the fat-gas coefficientis 495.Isolation of ElectrophoreticallyPure Human CardiacMyoglobinBy DAVID L. HILLMedicineBecause of specificity and sensitivity,an immunological method would seemuseful for the detection of cardiac myo­globin in the serum and urine in variousclinical situations. This, however, wouldrequire a pure cardiac myoglobin prep­aration, It has been reported, and con­firmed in this laboratory, that the avail­able myoglobin preparations contain atleast two contaminating proteins whenexamined by immunological techniques.Attempts were therefore directed towardthe preparation of pure human cardiacmyoglobin. The following describes itsisolation and criteria used to establishits purity.A water extract was made from hu­man heart muscle obtained at autopsy.Crude myoglobin in solution was thenseparated by methods based on the factthat, in either 3M phosphate buffer atpH 6.6 or 100 per cent saturated am­monium sulfate at pH 8.0, myoglobinremains in solution while all other pro­teins, including hemoglobin, are precipi­tated. Myoglobin was then precipitatedby adjustment of the pH to 7.0. Eachstage of the isolation was monitored byvertical starch gel electrophoresis of thesupernatant fluids and of dissolved pre­cipitates using commercial horse heartmyoglobin as a standard. The purestpreparation of myoglobin at this stagecontained hemoglobin-haptoglobin com­plex, free hemoglobin, hemalbumin, andmyoglobin.Myoglobin was separated from thecontaminating proteins on a DEAE eel- lulose column, equilibrated with O.OOlMTris buffer at pH 8.9, and eluted in asharp visible band with O.OSM Tris buf­fer pH 6.5.Spectral analysis of this eluate showedabsorption peaks characteristic for acidand alkaline metmyoglobin, Three bandsformed on vertical gel electrophoresis,stained for protein, and exhibited per­oxidase activity. Two bands behaved ashuman skeletal muscle myoglobin; thethird band was faint, migrating as hemo­globin. However, immunodiffusion andimmunoelectrophoretic techniques coulddemonstrate no contamination withhemoglobin.Thus, myoglobin isolated under thedescribed conditions appears to be pres­ent in three molecular forms. Attemptsare now being made to produce myo­globin antibody.The Anterior Thalamic Nuclei:An Experimental Studyin the CatBy NICHOLAS J. LENNAnatomyThe anterior nuclei of the thalamus,and their connections with the cerebralcortex, have long been studied. How­ever, the development of a new proce­dure offered the opportunity to re-exam­ine these structures.Electrolytic lesions were placed in theanterior nuclei of cats with the aid of astereotaxic instrument. After elevendays, the brains were fixed in situ withformalin. Serial frozen sections werestained with cresyl violet for cells, andthe Nauta technique for degeneratingaxons. Of the twenty-one usable casesthus prepared, four were chosen for de­tailed description.The brain with damage to all threeanterior nuclei showed degenerationwithin the preserved portions of thesenuclei, in the central lateral and medialdorsal nuclei, and in the anterior limbic,cingular and retrosplenial areas of thecortex, via a route around the genu ofthe corpus callosum. After damage tothe anteroventral nucleus, degenerationwas seen within the anteromedial andanterodorsal nuclei, extending to. thecentral lateral nucleus, to the cortexafter proceeding anteriorly in the inter­nal capsule, and turning dorsally to crossthe corona radiata and medially to enterthe cingulate gyrus. Damage in the an­teromedial nucleus resulted in similarthalamic degeneration, and degenerationin fibers coursing anteriorly in the inter­nal capsule which lie beneath the medialcortex anterior to the caudate nucleusME 0 I CAL A L U M NIB U L LET I N 15and lateral ventricle. Fibers were fol­lowed as far as the internal capsulefrom a lesion in the anterodorsal nu­cleus. The cortical areas of terminationwere as reported in previous studies, butwith less sharp borders. The degener­ating preterminals were restricted to thedeepest three layers of the cortex.The Effect of Glucagon on theOxidative Metabolism ofGlucoseBy DANIEL PALOYANSurgeryUnder a number of experimental con­ditions, glucagon will cause a loweringof blood lipids. The purpose of this ex­periment was to determine the possiblemechanism of this action of glucagon bystudying the oxidative metabolism ofglucose. This seemed appropriate sincethe catabolism of glucose, particularlyvia the pentose shunt, appears to exerta rate-limiting effect on the synthesis offatty acids and cholesterol.We first studied the in vivo oxidationof a tracer dose of C14-labeled glucoseadministered to rats by analyzing theirexpiratory C1402. The results suggestedthat glucagon accelerates anaerobic gly­colysis, but has no effect either on thepentose shunt or on the citric acid cycle.The in vitro action of glucagon onglucose metabolism was observed in ratadipose tissue. Using C14-labeled glucoseand fructose in the incubation medium,it was found that small doses of glucagonaccelerated glucose and fructose oxida­tion, but in a pattern markedly differentfrom that reported with insulin. Theseresults seemed best explained by postu­lating that glucagon stimulates glycoly­sis, without exerting any significant ef­fect on the pentose shunt.We conclude that glucagon, in addi­tion to activating liver phosphorylaseand enhancing glucogenolysis as pre­viously reported, also stimulates anaero­bic glycolysis in adipose tissue.Osteosclerosis in ChronicUremiaBy ROBERT PIERCERadiologySince 1953 sporadic reports of radio­logically observed cases of osteosclerosisassociated with renal disease have ap­peared in the literature.To evaluate this relationship more ex­tensively, the records of 987 patientswith chronic renal disease at the Uni­versity of Chicago Hospitals were re­viewed. Of this group, only 280 had16 ME 0 I CAL A L U M NIB U L LET IN elevated blood urea nitrogen and ade­quate X-ray examinations. Twelve casesof osteosclerosis or mixed osteosclerosisand osteomalacia were discovered. Thisis only 4.5 per cent of the total cases,but represents 20 per cent of the sixty­one cases showing some osseous change.The radiologic changes were mostprominent in bones usually containingactive marrow: lumbar spine, pelvis,and long bones. Three patterns of osteo­sclerosis were noted: reticular (primaryand some secondary trabecular sclero­sis); granular (umform, moderatelydense, and granular texture); and dense,mesh-like (entire medullary cavity filledby a network of thick trabeculae). Thereticular and granular patterns wererepresentative of a mixture of osteo­malacia and osteosclerosis. These pat­terns were seen histologically as fragileand broken, as well as thickened, trabec­ulae. The dense, mesh-like pattern wastypical of pure osteosclerosis.From this study, we conclude thatthere is an initial phase of decreaseddensity of the bones consistent withosteomalacia, often mixed with osteo­porosis. Pure osteosclerosis is a late con­sequence of the same process which re­sults from calcification of an enlargedmatrix. The earliest appearance of osteo­sclerotic changes was three years fromthe onset of the renal disease. In viewof the improved medical management ofuremia, we should see an increased fre­quency of osteosclerosis in patients withchronic renal disease in the years tocome.The Effect of Adrenalectomyon Pu23902-Induced Lympho­cytopenia in the RatBy GEORGE S. RHYNEERMedicineLymphocytopenia is an early responsefollowing the inhalation of plutoniumdioxide aerosols by rats and dogs, and itis generally not accompanied by changesin the other circulating blood elementswhich occur after whole-body irradia­tion. Since inhaled PU23902, an alphaemitter, is almost entirely confined tothe lungs, and its accumulation in thebronchial lymph nodes follows the onsetof the lymphocytopenia, it is difficult toascribe the lymphocytopenia to directradiation effects on circulating lympho­cytes or lymphoid tissue. To gain a bet­ter understanding of the mechanism in­volved, the possibility of the lympho­cytopenia being associated with an ab­scopal, adrenal response was investigated. Adrenalectomized and sham-operatedrats were exposed to a single dose ofPU23902 aerosol two and one-half weeksafter surgery. One of the two groups ofadrenalectomized rats received 1.0 mghydrocortisone intramuscularly daily.Periodic blood samples were taken fortotal and differential leukocyte counts,and hematocrits. At the time of autopsy,about five weeks after exposure toPU23902, the lungs contained one to twomicrocuries of plutonium and receivedan average dose of 10,000 rads. Thirtydays following exposure to PU23902, theblood lymphocyte counts of the sham­operated rats decreased about 60 percent from the pre-exposure levels, whilethose of the adrenalectomized rats fellonly about 40 per cent. The greatest de­cline in circulating lymphocyte counts,90 per cent, occurred in the adrenalec­tomized, but hydrocortisone-treated, plu­tonium-exposed rats.Thus, adrenalectomy lessened themagnitude of the plutonium-inducedlymphocytopenia. These results suggestthat the adrenals play a role in thelymphocytopenia following the inhala­tion of plutonium dioxide.The Contribution of the Pa­tient's Religious Views toPsychiatric EvaluationBy GENE H. SAMUELSONPsychiatryFreud's conviction that "God is a pro­jection of the human father," led to thedesign of a study to test this concept.Initial pilot studies, however, seemed toindicate that the patient's religious in­terests and his view of God were deter­mined by his whole life experience rath­er than by a single factor, such as"father-image. "If this were true, then unguarded re­ligious expressions might contribute sig­nificantly in a standard psychiatric eval­uation.To test this hypothesis, every thirdpatient evaluated in the University ofChicago Department of Psychiatry wasalso interviewed concerning his personalreligious convictions. The resulting "re­ligious data" on each subject were pre­sented independently to two staff psy­chiatrists who, without benefit of anyadditional information, recorded theirpsychiatric evaluation of the patient interms of symptom and character diag­nosis, psychosexual development, andpsychodynamic formulation. A thirdpsychiatrist, to whom all of the clinicalpsychiatric data were available, ratedthe degree of correlation between theevaluation based on religious data aloneand that based on clinical psychiatricdata.Fifty patients were thus evaluatedover a two-year period. In over 90 percent of instances, the evaluation basedon religious data alone coincided withthe clinical psychiatric evaluation.In these patients it was found that thedetails of their religious views offeredvaluable clues to their clinical, develop­mental, and psychodynamic diagnoses.The revealing nature of the patient's in­dividualized religious views indicatedthat his religion is uniquely personal,intimately linked to many phases of hisprivate life, and singularly amenable toclinical evaluation.An Underwater BreathingDevice Utilizing OxygenDissolved in WaterBy RICHARD H. STRAUSSSurgeryThe time which man may remain un­derwater using a self-contained breath­ing apparatus is limited by the quantityof air carried in tanks of the apparatus.If man were able to utilize oxygen dis­solved in water, as do fish, submersionwould not be limited by the portableoxygen supply.The partial pressure of oxygen (p02)of ocean water at a depth of 100 meters,150 mm Hg, approximates that of sur­face air. The p02 of expired mammalianair is roughly 115 mm Hg. Thus, thereexists a gradient for the diffusion ofoxygen from water to expired air. It washypothesized that the respiration of amammal could be supported by the oxy­gen in water if the animal breathedthrough a device utilizing the p02 gradi­ent described.An apparatus was constructed of Tef­lon envelopes of 5.9 m2 total surfacearea. The expired air of a guinea pigpassed within the envelopes and was re­breathed. Water under atmospheric con­ditions flowed around the envelopes.Oxygen diffused from water throughTeflon membranes to the expired air ofthe animal and the exhaled carbon di­oxide diffused in the opposite direction.Adequate respiration of the guinea pigin two separate experiments was sus­tained with the apparatus. Analyses ofthe inspired and expired gas mixturesshowed that an equilibrium was reached;that is, the apparatus supplied oxygenas fast as the animal used it and clearedCO2 from the air as fast as the animal expired CO2. Thus, the animal could beexpected to continue respiration via theapparatus for an indefinite period.The apparatus is impractical due tothe large membrane surface area neces­sary for adequate gas diffusion. In addi­tion, the device would probably functionas described only near the water surfaceas increasing hydrostatic pressure withdepth would prevent adequate respira­tory movements by the animal.The Agglutinin Response toPurified Salmonella Flag­ellar Antigens inthe RatBy JAMES W. WINEBRIGHTPathologyThe role of 1) the dose of antigen,2) the route of its injection, and 3) thespleen, in the primary and secondaryagglutinin response of the male Sprague­Dawley rat were studied using purifiedparticulate and soluble flagellar antigensfrom Salmonella typhosa.Different general patterns of the im­mune response were elicited by the twoforms of antigen. In many cases, theshape of the serum antibody titer curveof non-splenectomized flagellin (solubleantigen)-injected animals resembled thatof splenectomized rats immunized withflagella (particulate antigen), althoughthe rise in titer was usually less rapid inthe former group. Within the range ofantigen doses studied, the injection oflarger quantities of flagella resulted inhigher circulating agglutinin levels inboth the primary and the secondary re­sponse. The same was generally true forthe animals immunized with flagellin.When larger amounts of flagella wereadministered, the pattern of the immuneresponse was qualitatively similar, butquantitatively different, depending uponthe route of injection of the antigen.Striking qualitative differences werenoted with different routes of injection,especially at the lowest dose level used,intravenous administration being mosteffective. In contrast, the differences inresponse due to the route of injectionwere less marked in flagellin-immunizedrats.Similarly, the effect of splenectomywas less noticeable in the flagellin-in­jected rats, whereas with the particulateantigen, removal of the spleen resultedin a lower and delayed titer peak regard­less of the route of injection. Absenceof the spleen appeared to have lesseffect on the secondary response than onthe primary response. In all of the groups studied, the effects of splenec­tomy interacted with those due to doseof antigen and the route of its adminis­tration.Incorporation of Phenylalanineinto Polypeptide Linkage byMicrosomes from Regen­erating Rat LiverBy ROBERT ZELISBen May LabStudies were carried out on the abilityof rat liver microsomes to catalyse theincorporation of amino acids into pro­tein-like material. The substrate usedfor the reactions was amino-acyl-sRNApreviously charged with L-phenylala­nine-C':' and nineteen other C12 aminoacids. The activity of these preparationsfrom the livers of partially hepatecto­mized rats at twenty-four hours aftersurgery was compared with those ob­tained from sham-operated controls. Themicrosomes from the partially hepatec­tomized animals appeared to be moreactive than those obtained from the con­trol animals when incorporation by themicrosomes was contrasted on the basisof their RNA content or gram-equiva­lents of fresh tissue. However, the dif­ferences in the ability of the microsomesfrom these two sources to transferphenylalanine into polypeptide linkagewas abolished if the aminoacyl transferswere studied in the presence of concen­trations of polyuridylic acid which com­pletely saturated the microsomes withthis synthetic template. This demon­strated that the total capacity of thetwo species of microsomes to supportamino acid incorporation was similar. Apossible explanation for these findings isthat the microsomes from the partiallyhepatectomized animals contained morebound template RNA. These findingsare significant in relation to recent in­vestigations by others on protein syn­thesis in regenerating liver.4i 1 J2J.-tMEDICAL ALUMNI BULLETIN 17PROFILE OF THE CLASS OF 1967On September 25, 1963 the seventy­four members (sixty-nine men and fivewomen) that comprise the medical classof 1967 assembled as a unit for the firsttime on our campus. Four of the menand one of the women were married, andnone of them had any children at thetime they began their medical studies.The Committee on Admissions care­fully considered almost 1,100 applicantsin the process of selecting this class. Theseventy-four entering freshmen comefrom forty-six different colleges and uni­versities and are legal residents of twen­ty-one different states and Puerto Rico,as well as Nationalist China and Nigeria..Almost one-third (twenty-two) of themembers of the class of 1967 are resi­dents of Illinois. Ten more are fromother states in the midwest while the re­mainder come from all parts of the U.S.and two foreign countries. The schoolsrepresented in this freshman class are asfollow:Antioch CollegeAugustana College-South DakotaBeloit College (2)Boston UniversityBrooklyn CollegeUniversity of California, Berkeley (2)Carleton College (2)University of Chicago (10)University of CincinnatiClark UniversityColumbia UniversityUniversity of ConnecticutCornell University (3)Earlham CollegeFisk UniversityUniversity of FloridaHamilton CollegeHarvard College (2)University of Illinois, UrbanaUniversity of Illinois, ChicagoIndiana UniversityJohns Hopkins UniversityKalamazoo CollegeKnox College (3)Loyola University, Chicago (2)Miami UniversityUniversity of Michigan (3)University of MissouriMuskingum CollegeNorthwestern UniversityUniversity of Notre Dame (2)Oberlin College (4)Occidental CollegePacific Lutheran CollegeUniversity of Pennsylvania (2)Princeton University (2)University of Puerto RicoPurdue UniversityUniversity of Rochester (2)Rutgers UniversitySwarthmore College (2)Wake Forest CollegeUniversity of WashingtonWestern Reserve UniversityWheaton CollegeYale University18 M E Die A L A L U M NIB U L LET I N The average age of the class wastwenty-one years, and 90 per cent werebetween twenty and twenty-two yearsold. The age range was an unusuallynarrow one for an entering medical class.The youngest student, the son of a phy­sician, had just turned nineteen and theoldest, a man who had just completedhis master's degree in psychology, wastwenty-four.In selecting the best qualified medicalstudents from the large pool of excellentapplicants, the Committee on Admis­sions always pays careful attention notonly to each applicant's scholastic abili­ties and achievements, but also to hisnon-scholastic attributes. Nevertheless,of the seventy-four entering freshmenonly two had C+ averages, whereasfifty-two, or 70 per cent of the class, hadaverages of B + or better. Their collec­tive average college grade record wasB +, and almost one-half (thirty-five)of the members of the class had gradu­ated from college with honors. More­over, sixty-three had received a bache­lor's degree before entering medicalschool, and two had gone on to earn amaster's degree; the remaining elevenmembers of the class each had a mini­mum of three years of college pre-medi­cal studies. On the Medical College Ad­mission Test, which is required of allmedical applicants, the freshman classas a whole scored high above the nation­al average and higher than any previousentering class at the University of Chi­cago School of Medicine since the incep­tion of the MCAT some fifteen yearsago. The average MCAT score of theentering freshman was in the top 10 percent of aU medical applicants in theUnited States.As might be anticipated, the familybackgrounds of the freshmen medicalstudents are most varied and interesting.Four come from alumni families. Twoare sons of medical alumni, one is a sonof a college alumna, while the fourth isthe son of two alumni parents, a fatherfrom the School of Medicine and amother from the College. Seven of themembers of the class of .1967 come fromhomes where one or both parents haveless than a high-school education. At theother extreme, more than one-half(forty-one) of the freshmen studentscome from families where one or bothparents are college graduates. As in theother medical classes, the occupations ofthe fathers of the entering freshmenrepresent a cross-section of the profes- PARAMEDICAL CAREERCONFERENCEThe University of Chicago HospitalsHealth Careers Conference was held onMay 9. The conference, a half-day pro­gram for two hundred students fromnineteen public, parochial, and privatehigh schools, was initiated in 1963 topromote interest in paramedical careers.Students participating in the· programtoured various departments in the hos­pital, including the laboratories, phar­macy, radiology department, administra­tion offices, medical records library, nurs­ing stations and kitchen, and heard sev­eral speakers from the hospital's para­medical fields. They were guests of thehospitals at lunch.Superintendent Charles R. Goulet,who chaired the program, said, "By in­troducing interested young people tothese jobs and showing them what theyare like in a modem medical center, wehope that we can help them realisticallyevaluate a career of service in the med­ical field."CARLSON LECTUREArthur Kornberg, professor and headof the Department of Biochemistry atStanford, gave the third annual Anton J.Carlson Memorial Lecture on February 7.Dr. Kornberg, 1959 winner of the NobelPrize in Medicine, spoke on "CurrentStudies on the Replication of DNA."sions, industry, and labor. Included areseven doctors, five engineers, four phar­macists, three lawyers, three chemists;two teachers, and a pharmacologist, inaddition to a wide variety of business­men, merchants, office workers, andskilled and semi-skilled laborers. Simi­larly, thirty of the mothers have careersin addition to that of housewife. Elevenare school teachers, four are secretaries,two are store managers, two are book­keepers, and two are nurses. The re­mainder hold various business and in­dustrial positions. The present freshmanclass has already completed its first yearof a rigorous program of medical studies.Already this class gives every indicationof matching or surpassing the scholas­tic performances of the classes whichhave preceded it in our School of Medi-cine.JOSEPH J. CEITHAMLDean of StudentsRICKETTS AWARDSir Christopher H. Andrews re­ceived the 1964 Howard Taylor RickettsMemorial Award. Sir Christopher, anoted British authority on the study ofvirus infections in man, delivered a lec­ture entitled "Viruses and Noah's Ark."After reviewing data to support thetheory that viruses originated in the re­mote past, he concluded, "Of one thingI feel sure, that in the year 2349 B.C.all those animals which entered and sub­sequently left the ark were carryingwithin their bodies a great many of theviruses we have been discussing, whetherNoah knew it or not."EBERT AT HARVARDRobert H. Ebert, '42, (Fac. '47-'56)has left his position as Hord Professorof Medicine, Western Reserve Univer­sity, to become Jackson Professor ofClinical Medicine at Harvard and chiefof the medical services at MassachusettsGeneral Hospital.LINDSAY HONOREDJohn Ralston Lindsay has been ap­pointed the Thomas D. Jones Professorof Surgery. He has been on our facultysince 1928 and professor and head of thesection of otolaryngology since 1940.Dr. Lindsay is internationally knownfor his contributions to the understand­ing of the balance mechanism of the innerear and of deafness related to virusdiseases. He is director of the nationalTemporal Bone Banks Program and headof the center at the University. He hasreceived the highest honors of the eliteotolaryngologic societies and an honorarydoctorate from the University of Upp­sala. KENNEDY GRANTOn April 8 the Joseph P. Kennedy,Jr., Foundation announced a grant of$2,200,000 to the University for con­struction of research and research train­ing facilities in mental retardation. Thegrant will establish a research center,including a mental retardation clinic,and provide a contribution to clinicalservices and training facilities whichmay be supplemented under the three­to-one matching provision in the newfederal mental retardation program.Albert Dorfman, '44, chairman ofthe Department of Pediatrics, will directthe Joseph P. Kennedy, Jr., Mental Re­tardation Research Center, which willbe located in the University's new Chil­dren's Hospital.GIFT TO LIBRARYThe projected central library for theUniversity has received a gift of $500,000from the Harriet Pullman SchermerhornTrust, through Mrs. C. Phillip Miller,niece of the late Mrs. Schermerhorn anda trustee of the fund. Mrs. Miller trans­mitted the gift in a brief ceremony atthe campus residence of President andMrs. George Wells Beadle.LEUKEMIA: A CURRENT ANDFORWARD LOOKUnder the auspices of the CancerTraining Program, headed by Robert W.Wissler, '49, a symposium on leukemiawas held on February 29 and March 1.Twenty-five eminent specialists, manyfrom The University of Chicago, par­ticipated in a review of the latest knowl­edge of the etiology and pathogenesis ofleukemia as it might apply to humanleukemia and as it might aid in methodsof preventing that disease. It was de­signed particularly to inform and stimu­late students, both undergraduate andgraduate. Henry S. Kaplan, Rush '40,Richard K. Blaisdell, '48, Robert J.Hasterlik, Rush '38, Ernest Beutler, '50,Werner Kirsten and Mila Pierce, Rush'24, participated in the presentations anddiscussion. Leon o. Jacobson, '39, Lud­wig Gross, chief of cancer research ofthe Veterans Administration Hospital inthe Bronx, and Maurice R. Hilleman,director of the Merck Institute for Thera­peutic Research, chaired the three ses­sions. fj. «[iIIiam :Becka189t-1961Dr. Becker died suddenly onAugust 14 from coronary throm­bosis.His colleagues and students hadplanned a testimonial banquet inhis honor on the occasion of hisseventieth birthday, October 7.Alumni who would like to con­tribute in memory of their teacherof dermatology to the Becker Re­search Fund should write to:DR. MAXIMILIAN E. OBERMA YER3875 Wilshire BoulevardLos Angeles, California 90005A.O� A. ELECTIONSThree members of this year's grad­uating class were elected to Alpha Ome­ga Alpha when they were juniors. Theyare:J ames CastlesJames HirschfeldLawrence KassOn May 20 eight seniors and threejuniors were initiated. The seniors are:Stanley EnglundDavid FixlerDavid GrossJohn HammerstadJames HirasaJoseph JustJames WinebrightRobert Zelisand the juniors:David HarrerCarl PierceGlenn Weyhrich.The A.O.A. lecture was given by Vic­tor M. McKusick, professor of medi­cine at Johns Hopkins University Schoolof Medicine. Dr. McKusick spoke on"Genetic Studies of the Amish." At theannual A.O.A. banquet at the Quad­rangle Club, Allan T. Kenyon recipro­cated with an after-dinner talk on "Ge­netic Relationships Between Johns Hop­kins and The University of Chicago."MEDICAL ALUMNI BULLETIN 19MARTIN E. HANKEProfessor Emeritus, Department ofBiochemistry, and Director, ClinicalChemistry Laboratory[On Sunday evening, April 12, some eighty­five people gathered in one of the largerooms at the Center for Continuing Educa­tion for a testimonial dinner on the occasionof Martin E. Hanke's retirement. Both Dr.and M rs. Hanke were there to greet theirmany friends. The formal ceremony wasbrief, involving the presentation of a silverbowl and check to Dr. and Mrs. Hanke, andincluded the tribute from Professor AllanKenyon which appears below.]The canvas is broad and bare. Wemust take the brushes given us, pick upsuch pigments as we can and paint ourlives upon it. Martin and Maud-yourfriends are here this evening to tell youthat they like the pictures you havemade and to comment here and thereon what they see.Gertrude Stein must be my mentornow. You recall that speaking of Picas­so she named a blue, a pink and sundryother periods. So may we classify theart of the painters Hanke. There was atime on the old Quadrangles which wemay call the Gothic period, a time in thenow Abbott Hall where the architectsshaved off the gargoyles, straightenedwalls and moved as best they could to­ward blank and open modern. This wemay call the period of Compromise.Then a time at Billings with quite whitefloors, at least in front, and smooth andnewly-painted laboratory walls andneatly articulated lab equipment. Thiswe may call the Sanitary period. Therewere also Manhattan and Egyptian in­terludes.Martin was born in Chicago on June25, 1898, had a Lutheran parochial edu­cation up to his college years and re­ceived his Bachelor of Science degreehere in 1918. If he had a youth luridenough to interest a modern audiencethe pictures have been quite hiddenaway. So we may move on quickly asMartin moved. Served by several fellow­ships, he took his Ph.D. in organicchemistry here in 1921. Some of you re­member his preceptor, Julius Stieglitz,a small man with a white goatee, thesmooth, unhurried lectures: an interestin the application of chemistry to in­dustry and to medicine, and some of uscan seen him still on his perfectly tail­ored Sunday walk. On September 2,1922, Martin married Maud FrancesMartin and they moved on thence to­gether and shared so much that we canconsider their work together and as onework of art. (Anyone denying this20 M E 0 I CAL A L U M NIB U L LET I N should speak up now or forever hold hispeace.)Hull Court was built in 1897. Gar­goyles watched the doors and windowsas in medieval schools. So when Martincame from Kent to Culver in 1922 thehousing could be considered quite wellalong. There was actually at last ivy onthe wall.There were also people there. Whenhis Lutheran God had refused AntonCarlson the explicit manifestations thathis heart and mind required, he left theministry for physiology and arrived inChicago in 1904. He was practicingearnest science with Luckhardt andothers when Martin came along. But thewoes of the world lay heavy on thepreacher in him and he moved towardthe public person that he eventually be­came. He combatted error in scientificlife and injustice in the world about withall his might and he was pretty strong.Fred Conrad Koch was a good dealin contrast. He had matured late andwas appreciated later. He had come in1909 and when his teacher and chief,A. P. Mathews, left for Cincinnati in1919, Dr. Koch started his seven-yeartenure as acting chairman of physiologi­cal chemistry. That luminous trait calledexcellence, so much celebrated, may behard to see. Martin, who began his longand loyal association with Dr. Kochduring this phase of patience, character­ized his old chief best in a note in 1948.I have paraphrased and extended hisdescription: Professor Koch was con­servative in all particulars save in hiswork, where he sought radical innova­tion. He was systematic and orderly.His mind stayed close to the experiment,with no grand biologizing. Although na­tively careful in method and technique,he allowed the approximations necessaryfor the assessment of living things.Hence his skill in bio-assay. Friendlyalways, but without bonhommie. Work­manlike at work with gemutlichkeit athome. His humanity invested the placeand the lives about him; he carried nolance for the festering wounds of theworld outside.So when Martin came to Culver in1922 both place and people had had acertain seasoning. This was to changesomewhat after 1926, when the buildingnow known as Abbott Hall was founded.The term "period of compromise" refersto architecture only; it carries no re­flection on the characters of the inhabi­tants, which were indeed quite wellmaintained. For Martin we may plot acontinuum between the Gothic and thenot-quite-so Gothic. As a student and practitioner of analytic techniques hemade his own way clearly. He publishedno papers with Koch or with Carlson.He thus escaped absorption into thepowerful interests about him and pro­vided students and staff with alternativeways of leading the scientific life. Byemphasis on tools he cultivated a mas­tery of procedure which could thenserve the student wherever his mindmight take him. There were studies ongastric secretion, on the alkaline tide,including one with Maud, on tissue chlo­rides and on methods for ascertainingthe pH of the blood.Many proper Chicagoans of thesetimes had Rockefeller episodes. Martin'syear with Van Slyke at the RockefellerInstitute in 1930--31 furthered his ex­perience with manometric techniques,and he published several papers on theVan Slyke apparatus and a manual forits use. But a list of papers falls farshort of defining Martin's contribution.The medical students of my day remem­ber him very well. Fresh and clear inexposition, faithful to the task, firm withthe experiment itself, kindly toward theexperimenter. There was a certainamount of rough and shouting instruc­tion in Culver Hall then. We welcomedMartin's calm, impersonal approach.In the early 30's a harried refugeenamed Rudolf Schoenheimer workedwith Edmund Andrews here in surgery.He went then to Columbia, where heestablished a distinguished school ana­lyzing metabolic processes with the helpof isotopes. This was bread upon thewaters. For Schoenheimer's student,Earl Evans, came to Chicago in 1937and succeeded to Dr. Koch's post aschairman in 1942. Martin's work con­tinued with the graduate students of theDepartment of Biochemistry throughthe Koch and Evans eras, if you wish tocall them such, as well as with his own.He thus furthered and supported theeducation of many men and womenwhom you now know by name.In September of 1955 the Hankeswent to Egypt, Martin to head the De­partment of Biochemistry in the U.S.Medical Research Unit in Cairo. Nowthe Sphinx has seen many troubles, butthe Sphinx does not care. Other peopledo, however, and the times were notpropitious for alien work in Egypt. Therising of the peoples at the Suez crisisand at the debate on Aswan Dam sup­port placed our citizens in some serioushazard. Whether Martin or Maud haddone anything to aggravate the situationwe need not ask. Any errors of their ownwere more than swamped by the con-fusion all about them. And so theirflight from Egypt in October 1956. Theversions of this flight have not beenformed into any traditional and hal­lowed account as were those of theIsraelites some time ago. No Red Seaparted for the Hankes. They had to taketo boats. One version has it that in theirhaste they could wear only shirts; an­other that they could only manageshorts. All versions agree, however, inthe particular that they saved theirtoothbrushes. Martin brought Maud'sand Maud brought Martin's, exhibitingthus the fine complementarity they havealways shown when times were difficult.In 1958 Martin came to Billings todirect the Clinical Chemistry Labora­tory. This is no light task. Everybodywants many determinations, and wantshis own done right away and very well.At lunch he has renewed old friendshipsand made many new ones. He has metour somewhat impassioned conjecturesabout affairs with his own suave wisdom.We will miss him when he goes.This much then for bright nostalgiaand for something of the present. Mar­tin and Maud: your pictures on thecanvas we like very much. And for suchpleasant views we wish you well.FACULTY NEWSWilliam E. Adams, Huberta M. Living­stone ('28-'52), and Walter L. Palmer,'21, professor emeritus of medicine, wereguest speakers at the Seventh Medical As­sembly of the West held at the Universityof Guadalajara, Mexico, in November. Mrs.Walter Palmer was presented a medal by thepresident of the Assembly in memory of thegreat contribution made to Mexico and tothe world by her father, Howard TaylorRicketts.John Benfield, '55, is leaving the De­partment of Surgery to join the faculty ofthe University of Wisconsin, where he willbe assistant professor of surgery. He willgo to Madison this fall, after a summer tripto Europe.Dean H. Stanley Bennett has been ap­pointed a member of the Science and Tech­nology Advisory Committee for MannedSpace Flight of the National Aeronautic andSpace Administration.Dean Bennett spent three weeks last win­ter studying medical education in the SovietUnion as part of an official delegation of sixAmericans participating in the Cultural andEducation Exchange Treaty. He visitedthirty-three educational institutions, includ­ing eight medical schools.William Bloom, Charles H. Swift Dis­tinguished Service Professor of Anatomy andBiophysics, was awarded an honorary doc­tor's degree by the Jagellonian Universityof Cracow, in Poland, at ceremonies markingthe university's 600th anniversary. Gail M. Dack received the Nicholas Ap­pert award at the annual meeting of theInstitute of Food Technologists in May. Theaward is given each year to "honor a personfor pre-eminence in and contributions tothe field of food technology."M. Edward Davis, '22, gave the firstAlven Weil Memorial Lecture, March 4, inAkron, Ohio. Dr. Davis spoke on "Estrogenand the Aging Process." Dr. Weil, '32, diedin 1962. The lectureship, dedicated to thefurthering of education in obstetrics andgynecology, was created by his associates inthe profession, his family, his loyal patients,and by his host of staunch friends.Albert Dorfman, '44, will head a newprogram to train medical scientists froma broad range -of disciplines in the field ofchild health and development. A five-yeargrant made to the University by theU.S.P .H.S. will give financial aid to traineesin some cases through medical school, in­ternship, residency, and graduate research.Facilities for the program will be expandedwith the completion of the new Children'sHospital, adjoining Lying-In, which willinclude three floors devoted to laboratoryresearch as well as a clinical research centerfor the study of mothers and children.Dr. Dorfman has been elected a Fellow ofthe American Academy of Arts and Sciences.Lester Dragstedt, '21, Thomas D. JonesProfessor Emeritus of Surgery, has beenawarded the Julius Friedenwald Medal ofthe American Gastroenterological Associa­tion.Joseph P. Evans received an honorarydoctor of science degree from Loyola Uni­versity at its mid-year convocation in Janu­ary.Humberto Fernandez-Moran has beenelected a Fellow of the American Academyof Arts and Sciences.Viswanath G. Gharpure, chief of sur­gery of the University of Nagpur Collegeof Medicine in India, is spending a year withWilliam E. Adams as visiting professor ofsurgery, under the auspices of the U.S. StateDepartment.Irving H. Goldberg, assistant professorof medicine and research associate in theDepartment of Biochemistry, will leave TheClinics to become associate professor ofmedicine at Harvard.Daniel L. Harris will leave the Depart­ment of Physiology this fall to become Pro­fessor and executive officer, Laboratory ofMolecular Sciences, Graduate Research Cen­ter of the Southwest in Dallas, a newly-or­ganized institute for biologic and physicalsciences.A. Baird Hastings ('26-'35), head of theLaboratory of Metabolic Research at ScrippsClinic and Research Foundation, La Jolla,California, recently received the AmericanCollege of Physicians Award, the organiza­tion's highest honor. The award is givenfor distinguished contributions in scienceas rela ted to medicine.Isabelle Havens, research associate in theDepartment of Microbiology, received theCorning Award of the American Society ofMedical Technologists as the nation's out­standing medical technologist of the year.Miss Havens was named employee of theyear by The Clinics in 1961.Zdenek Hruban, '56, has received a Led­erIe Medical Faculty Award. The grant ex­tends for three years. Bertha Klien, professor emeritus of oph­thalmology, is returning to the private prac­tice of ophthalmology.Sanford Krantz, '59, instructor andU.S.P.H.S. Fellow in the Department ofMedicine, was awarded the Joseph A. CappsPrize for his report on "Studies on the Effectof Erythropoietin upon Marrow Cells inVitro."Dr. Krantz will spend next year at theInstitute for Biochemistry of The Universityof Glasgow.Andrew E. Lorincz, '52, ('53-'59), of theUniversity of Florida at Gainesville, tookoffice as president of the Southern Societyfor Pediatric Research at its fourth annualmeeting in Memphis.Franklin McLean, '10, professor emeritusof physiology, entertained the UniversitySingers of Lund University at a luncheonon June 8. This group, the oldest male chorusexisting today, interrupted a tour of theUnited States to pay homage to Dr. McLean,an honorary doctor of medicine of LundUniversity since 1957. They presented himwith a medal and a private serenade.Francis Joseph Mullin, Ph.D. '36, ('38-'51) has been awarded the Alumni Medal,the highest honor of The University of Chi­cago Alumni Association. Mullin, a physi­ologist, who has been president of ShimerCollege since 1954, was cited in part forhaving "refashioned Shimer into an experi­mental college of unique character, nation­ally recognized for its teaching excellence,its intellectual' atmosphere, and its demon­stration that curricular transfer between dis­similar institutions is feasible. . . . Thereseems little doubt that Shimer's excellencetoday is the deed of its president, whoseleadership of mind and spirit have been asample as his practical abilities."Walter L. Palmer, '21, Richard T. CraneProfessor Emeritus of Medicine, was award­ed a grant by the American Cancer Societyfor studies on adrenocortical function andreserve in cancer and in cancer therapy. Dr.Palmer will carryon his research at Wood­lawn Hospital.Irving Rappaport will become professorof microbiology at the New York MedicalCollege on September 1.Wynn Sayman, '53, and Elizabeth Ford,'61, were married in May. They spent ahoneymoon in Europe and arrived back intime for the reunion banquet.Ronald Singer and Nels Strandjord, '46,left on June 12 for an expedition to SouthAfrica and South West Africa, accompaniedby Paul Heltne, a student of Dr. Singer.They plan excavations near Cape Townfor their research on Hottentots and Bush­men. Much of the work will be correlatedwith research done here by Janet Rowley,'49.H. Burr Steinbach, chairman of the De­partment of Zoology, has been elected toa four-year term on the board of directorsof the American Association for. the Ad­vancement of Science.Willard Visek, '57, has left the Depart­ment of Pharmacology. He became profes­sor of nutrition and comparative metabo­lism at Cornell University on July 1.George L. Wied will study comparativequantitative DNA and RNA assessments bymeans of fluorometric and absorption meas­urements on endometrial cells under a granta warded him by the American Cancer So­ciety.ME Die A L A L U M NIB U L LET I N 21RESIDENT NEWSHarwell Wilson ('32-'39), professor andchairman of the Department of Surgery,University of Tennessee, is treasurer of theAmerican College of Surgeons.Leonard J. Lyon, '62, is leaving to servefor two years at the 196th Station ArmyHospital in Paris.Roger Pine, '59, is going into privatepractice of radiology in Gary, Indiana.Guy Potter, '60, is now instructor in radi­ology at Columbia University.Duane Taebel, '60, outgoing chief resi­dent in medicine, was given a party at theQuadrangle Club in May by the house staffof his department. They presented him witha set of golf clubs and (in honor of hisspecialty, gastroenterology) a package ofprunes. Dr. Taebel will remain as instructorin medicine. Wayne Neal, the new chiefresident, was one of the hosts of the party.RUSH NEWS'13. Ralph H. Kuhns, Edwin S. Hamil­ton, Ralph McReynolds, Edwin Miller,Franklin Nuzum, Carl O. Rinder, YorkE. Sutch and J. J. Westaby held a reunionluncheon on June 4 at the Chicago AthleticClub.Dr. Kuhns has been elected a director ofthe alumni council of the Phi Beta Pi medi­cal fraternity.'19. Hedwig Stieglitz Kuhn, ophthalmol­ogist of Hammond, Indiana, writes to saythat the Kuhn Clinic which she and her latehusband started long ago will shortly becomepart of the Hammond Clinic. Dr. Kuhn isstill in "complete and 100 per cent practice,"and hopes to attend her 50-year reunion in1969.'25. Ralph W. Gerard will leave his po­sition as research director of an extensiveschizophrenia-psychopharmacology study co­sponsored by the University of Michiganand Ypsilanti (Mich.) State Hospital tobecome professor of biological science anddirector of special studies at the Universityof California at. Irvine.Dr. Gerard received an honorary medicaldegree from the University of Leyden, theNetherlands, in 1962. More recently, hewas presented with the 1964 Stanley R. Deanresearch award, given by the Fund for theBehavioral Sciences for basic research con­tributing to the understanding of schizo­phrenia.'26. H. W. Lawrence, recently retiredmedical director of Proctor & Gamble Co.,has been appointed associate professor ofindustrial medicine at the University of Cin­cinnati Medical Center Kettering Labora­tory.'30. Catherine Dobson left her Chicagopractice for a month to accept a MEDICOassignment to South Viet Nam. Asked whyshe took on the job-which includes payingall her own expenses-she replied, "I sup­pose there is something of a pioneer in me.Also because I thought I might be able tohelp. And besides, I love surgery and heavenknows there is more than enough to do herein that field."22 M E 0 I CAL A L U M NIB U L LET I N Arthur Robinson and associates at theUniversity of Colorado have been cited bythe National Foundation for outstandingprogress in 1963 in their work on birthdefects. Dr. Robinson's group is workingto develop an accurate blood test to detectvictims and carriers of galactosemia.'31. Henry N. Harkins, chairman of theUniversity of Washington's Department ofSurgery since it was established in 1947,will leave his administrative duties in orderto return to full-time teaching and research.Dr. Harkins was the first faculty memberappointed to a clinical department in themedical school, arriving just one year afterthe first class had been admitted.'37. Oliver H; Lowry, Ph.D. '37, profes­sor and chairman of the Department ofPharmacology at Washington UniversitySchool of Medicine, has been elected to theNational Academy of Sciences.'38. John D. Porterfield is president ofthe American Public Health Association. Theson of a 1902 Rush graduate, Dr. Porterfieldcomes from a family in which medicine isa well-established tradition. After severalyears with the U.S.P.H.S., he earned hisM.P.H. in 1944 from Johns Hopkins Uni­versity; he then went on to become theDeputy Surgeon General of the U.S.P.H.S.He is currently coordinator of health sciencesfor the president of the University of Cali­fornia.Herman Serota has been named presi­dent-elect of the Chicago PsychoanalyticSociety.GRADUATE NEWS'37. Clinton L. Compere has been electedchief of staff at Chicago Wesley MemorialHospital. Dr. Compere is professor of ortho­pedic surgery at Northwestern University.David Bodian of the Department ofAnatomy, Johns Hopkins, recently com­pleted a study by electron microscope ofmonkey spinal cord, showing the fine struc­ture of the normal motor column, the effectsof retrograde chromatolysis, and the cyto­logic effects of mild and virulent polio virusinfection.'38. H. Todd Stradford is now teachingorthopedic pathology at the University ofRochester.Preston J. Van Kolken is now chief ofmedicine of the American Hospital in PagoPago, American Samoa.'39. Robert Warner has been named oneof Buffalo's Outstanding Citizens for 1963.Under his directorship the Children's Re­habilitation Center of Children's Hospitalin Buffalo has achieved a national repu­tation and has become a model for stateand federal units. Last year Dr. Warnerwas given the second annual DistinguishedService Award of the Erie County Chapter,New York State Association for RetardedChildren.'41. John M. Beal, chairman of the De­partment of Surgery of Northwestern Uni­versity Medical School, is the new chiefof the division of surgery at Chicago WesleyMemorial Hospital.'44. George L. Nardi, associate visitingsurgeon at the Massachusetts General Hos­pital and assistant clinical professor of sur- gery at Harvard Medical School, has re­ceived a three-year grant from the John A.Hartford Foundation, Inc. to support aresearch program of clinical and experimen­tal observations of the normal and diseasedpancreas.'46. John R. Hogness has been appointeddean of the University of Washington Schoolof Medicine. Dr. Hogness has been associatedwith the university since 1950.'48. Walter Lawrence, Jr. received anAlfred P. Sloan A ward in Cancer Researchfor his contributions through research tothe improved treatment of cancer patients.Dr. Lawrence is associate attending surgeonof Memorial Hospital, an associate memberof Sloan-Kettering Institute for Cancer Re­search, and clinical associate professor ofsurgery at Cornell University Medical Col­lege.'49. Joseph P. Arcomano has becomea Fellow of the American College of Radi­ology. Dr. Arcomano is a member of thestaff of Long Island College Hospital andSt. Charles Hospital in Brooklyn; St. Charlesand Mather Hospitals in Port Jefferson; andSouth Hampton Hospital in South Hamp-ton. .'55. William C. Dement, associate pro­fessor of psychiatry at Stanford UniversitySchool of Medicine, has been awarded theAmerican Psychiatric Association's Hof­heimer Prize for outstanding research ac­complishment in psychiatry. Dr. Dement'sfirst studies on the nature and function ofsleep and dreaming were done with Na­thaniel Kleitman in physiology while hewas a medical student.Marshall Edelson has left his positionas chief of inpatient psychiatry at the Uni­versity of Oklahoma Medical Center to jointhe staff of Austen Riggs Center in Stock­bridge, Massachusetts.Bill McColl is now a missionary doctorat the Taegu Presbyterian Hospital inKorea. Dr. McColl, who was certified as anorthopedic surgeon last year, took his wifeand six children to Taegu in the fall of 1963.He will spend two years there practicingmedicine and training Korean doctors andnurses.'58. Charles Tidball was named professorand chairman of the Department of Physi­ology at George Washington University inJune. He has been acting chairman' of thedepartment for the past year. His wife,Elizabeth, who did graduate work in physi­ology here while Dr. Tidball was workingfor his M.D., will become associate (re­search) professor of physiology at the sameinstitution.'63. James A. Esterly, intern in pathologyat The Clinics, has been awarded first prizeby the 1964 Hektoen Awards Committeeof the Chicago Pathological Society for hisstudies and paper entitled "Arterial Perme­ability, Hypertension and Atherosclerosis: APreliminary Electron Microscope Study."Lawrence Hefter, who spent the last yearstudying in the Department of Pathology,will intern at the University of IllinoisResearch and Education Hospital in Chicago.'64. David Gross, who studied piano withRudolph Serkin at Marlboro, recently gavea benefit concert with Leonard Rose inCleveland for the American Association ofMental Health. Dr. Gross has given severalcampus concerts, including one with hisfather, also a physician and an accomplishedviolinist.DEATHS'90. Ointon T. Cooke, San Francisco,December 30, 1963, age 97.Chester Merrill, Hollister, Calif., Octo­ber 17, 1963, age 95.'95. Nels C. Meling, Chicago, February22, 1963, age 90.'97. Carl Ramus, Washington, D.C., De­cember 7, 1963, age 91.'98. George R. Reay, Onalaska, Wis., Sep­tember 9, 1963, age 87.'99. Harrison C. Putman, Canton, Ill.,July 20, 1963, age 86.'00. Clark L. Abbott, EI Cerrito, Calif.,September 11, 1963, age 89.Herman D. Oggell, Waterloo, Iowa,April 13, age 90.'01. Alfred T. Lees, Ashland, Ore., Janu­ary 15, age 88.'02. Russell F. Scott, Kokomo, Ind.,May 8, age 86.'03. Wilber E. Post, Evanston, Ill., De­cember 22, 1963, age 86.'04. Martin I. Olsen, Des Moines, Iowa,April 3, age 86.'07. James P. Simonds, Chicago, March17, age 85.'09. Albert H. Baugher, Chicago, No­vember 13, 1963, age 80.Homer K. Nicoll, Chicago, June 26,1963,age 80.Mary Shutan, Chicago, June 22, age 82.'10. Fletcher O. McFarland, San An­tonio, Texas, December 19, 1963, age 77.'11. Nelson L. Heller, Dunkirk, Ind.,July 10, age 78.Philip E. Stangl, St. Cloud, Minn., No­vember 14, 1963, age 77.'12. Herbert H. Hughes, Gresham, Ore.,April 17, age 81.Josiah J. Moore, Chicago, May 5, age 77.Israel L. Sherry, Treasure Island, Fla.,January 11, age 75.'13. Jesse D. Cook, Los Angeles, Calif.,March 20, 1963, age 83.Earle G. Johnson, Grand Island, Neb.,March 12, age 76.'14. William O. Ott, Fort Worth, Tex.,August 18, 1963, age 80.Lynn B. Vaughan, Long Beach, Calif.,January 6, 1963, age 75.'15. Clifford Ashby, Point Pleasant, N.J.,May 25, age 81.John P. Ham, Yuma, Colo., January 5,age 74.J. B. Maclaren, Appleton, Wis., July 3,1963, age 84.'17. George L, Venable, North Manches­ter, Ind., June 6, 1963, age 72.'19. Wallace H. Budge, Ogden, Utah,August 18, 1960, age 71.Horace E. Groom, Watsonville, Calif.,September 29,1963, age 77.James J. Noonan, Jr., Marshalltown,Iowa, December 22, 1963, age 69.'20. James B. Eyerly, Chicago, October26, 1963, age 68.'21. William Borchers, Chicago, July 14,1963, age 72.William J. Brown, Chicago, February 21,age 67.Edmund Remmen, Tehachapi, Calif.,June 28, 1963, age 67.William B. Serbin, Chicago, June 15,age 70.Robert S. Vivian, Naples, Fla., Septem­ber 2, 1963, age 67. n. «[ cndclll\ arriSon1897-1961The University of Chicago andparticularly the Division of Bio­logical Sciences owes an enormousdebt to Pat Harrison. He was afriendly, modest man of transpar­ent integrity. His obvious sense ofvalues and fairness made his judg­ments and decisions genuinely ac­ceptable to students, faculty andtrustees alike. The term "devotedservant" has been applied to many,but it fitted Pat Harrison as well orbetter than anyone I have everknown.LoWELL T. COGGESHALL'23. luella E. Nadelhoffer, Evanston,Ill., June 7, age 66.'24. Merrill W. Pangburn, Miller, S.D.,March 12, age 67.'26. E. F. Kotershall, Cleveland, October12, 1963, age 63.Mattie J. Bullard, Gary, Ind., October 3,1963, age 63.'28. Harry R. Keiser, Miami Shores, Fla.,December 21, 1963, age 63.Harry Winkler, Charlotte, N.C., Decem­ber 13, 1963, age 68.'30. Myron M. Weaver, Schenectady,N.Y., December 25, 1963, age 62.'31. George W. Dawson, Jr., Chicago,February 24, age 63.William Niebuhr, La Crosse, Wis., Sep­tember 28, 1963, age 69.'38. Harold R. Morris, San Bernardino,Calif., November 26, 1963, age 52.John E. Worlton, Lehi City, Utah, April18, age 54.'39. Charles A. Schiff, Chicago, June 5,age 49.'41. Mary S. Sherman, New Orleans, La.,June 21, age 51.'49. John E. Gill, Bryan, Tex., Septem­ber 12, 1963, age 37.FACULTYFranz Alexander, professor of psycho­analysis 1930-31, Palm Springs, Calif.,March 8, age 73.James Franck, 1938-54, professor emeri­tus, chemistry and physics, Gottingen, Ger­many, May 21, age 81.R. Wendell Harrison, emeritus 'Vice-pres­ident and dean of faculties, Foley, Alabama,February 8, age 66.Gwyn H. Lile, assistant clinical profes­sor, psychiatry, La Grange Park, January 25,age 35.Leo Szilard, professor of biophysics, LaJ olla, Calif., May 30, age 66.Julian Tobias, professor of physiology,Chicago, April 12, age 53. PROMOTIONS1963-64To Professor:Ralph F. Naunton-e-OtolaryngologyBenjamin H. Spargo, '52-PathologyH. Guy Williams-Ashman-Biochemis­try and BMLTo Associate Professor:Werner H. Kirsten-Pathology and Pe-diatricsRay Koppelman-BiochemistryArdis R. lavender-MedicineWilliam R. Martin-MicrobiologyAlbert H. Niden-MedicineKlaus Ranniger-RadiologyJohn E. Robinson-ZollerTo Research Associate (Associate Professor):Roy P. Mackal-BiochemistryTo Assistant Professor:Daniel P. Agin-PhysiologyGeorge C. Blozis-Zoller; also ResearchAssociate (Assistant Professor) in Pa­thologyJames L, Burks-Obstetrics and Gyne-cologyRoderick W. Childers-MedicineGeorge H. Conner-OtolaryngologyGeorge R. Daicoff-SurgeryEd Dordal, '56-MedicineMarcel Frenkel, '58-OphthalmologyHerbert C. Friedmann-BiochemistryRobert A. Goepp-Zoller and Biochem-istryPeter H. Greene-Mathematical BiologyCecil W. J. Hart-otolaryngologyJavad Hekmatpanah-NeurosurgeryPeter B. Johnston-PsychiatryShutsung Lia<r-BMLRobert Y. Moore, '57-Medicine, Pedi­atrics, and Anatomy and Fellow inNeurologyHenry P. Russe, '57-MedicineAlvin Tarlov, '56-Medicine and ACRHTing-Wa Wong, '57-Pathology (andFellow)To Research Associate (Assistant Professor):Peter P. Dukes-ACRH and Biochemis­tryRichard H. Moy, '57-Medicine; also Di­rector of Student Health ServiceSalvatore L. Nigro-SurgeryJanos Pataki-BMLTo InstructorPeter C. Altner-OrthopedicsKenneth M. Barton-MedicineDonald C. Cannon, '60-PathologyJerry Chutkow, '58-MedicineWillard A. Fry-SurgeryOtto Gago-SurgeryRobert I. Kohut, '60-OtolaryngologyAnn M. Lawrence-MedicineCharles R. lipscomb-RadiologyTanom Manotaya-Obstetrics and Gyne-cologyR. Wayne Neal-MedicineArsen M. Pankovich-OrthopedicsJames A. Roberts, '59-UrologyGiacomo C. Vailati-NeurosurgerySherwyn E. Warren-SurgeryEdward Weinshelbaum, '60-SurgeryM E 0 I CAL A L U M NIB U L LET I N 23FRIEDJosef Fried, a scientist noted for hisresearch in drug chemistry, now holdsa joint appointment as professor in theBen May Laboratory and the Depart­ment of Biochemistry. Dr. Fried, a pio­neer in the systematic chemical alterationof steroid compounds to "tailor-make"drugs for specific uses, is particularlyknown for his discovery of fluorohydro­cortisone, a derivative of a steroid hor­mone from the adrenal cortex. This find­ing was a crucial step in the discovery ofa number of widely used new drugs basedon the same chemical structure.Early this year Dr. Fried became di­rector of a program financed by a grantfrom the U.S.P.H.S. for research on thechemistry of antibiotics and syntheticsteroid compounds. Among the subjectsfor research under the new grant is syn­thesis of new compounds from a groupof steroid acids classified as tetracyclicand derived from certain wood-rottingfungi. By breaking down one of thesesteroids, eburicoic acid, Dr. Fried hasalready produced hormone analogs whichcombat the action of sex hormones.Studies will also be made of an anti­biotic which has been found to inhibit thegrowth of animal tumors and of cancercells in the test tube.Born in Przemysl, Poland, in 1914, Dr.Fried studied at the University of Leip­zig and the University of Zurich beforecoming to this country in 1938. He re­ceived his Ph.D. from Columbia and thenremained there for three years on a post­doctoral fellowship. In 1944 he joinedthe staff of the Squibb Institute for Med­ical Research in New Brunswick. He wasdirector of the division of organic chem­istry there when he left to come to Chi­cago.Dr. Fried is a member of the American24 M E 0 I CAL A L U M NIB U L LET I N Officers of Medical Alumni1964-65Paul C. Hodges, emeritus professorof radiology, is president of the Associa­tion this year. Dr. Hodges is one of theoldest of our faculty alumni: he wasone of the small group of able dedicatedpeople who planned the course of themedical school and he has played a vigor­ous part in its development. In additionhe became one of the University's mostrespected statesmen as evidenced by hiselection five times as spokesman for theCouncil.He was graduated from WashingtonUniversity School of Medicine, St. Louis,in 1918. In 1919 he joined the facultyof Peking Union Medical College andin 1927 was invited to come to TheUniversity of Chicago.His energy has not diminished sincehis retirement in 1958. He was largelyresponsible for building and maintain­ing a modern therapy center at the Na­tional Defense Medical Center in Taiwan.He also assisted in teaching medicalstudents and training radiologists there.He is now consultant in the Departmentof Radiology at the University of Flor­ida at Gainesville. He commutes to Chi­cago to fulfill his presidential responsi­bilities.Huberta M. Livingstone, our Vice­President, took her M.D. degree in 1928from the University of Iowa. Dr. Living­stone, a member of the Department ofSurgery (Anesthesiology) from 1928 to1952, received the Gold Key in 1952.Society of Biological Chemists, the En­docrine Society, the Swiss Chemical So­ciety, and the Chemical Society of Lon­don. His wife is the former Erna M.Werner, and the couple has one daughter,Carol.BULLETINof the Alumni AssociationThe University of ChicagoSCHOOL OF MEDICINE950 East 59th Street Chicago, Illinois 60637SPRING 1964VOL. 20 No.1EDITORIAL BOARDJESSIE BURNS MACLEAN, SecretaryJUDY HINDLEY, Editorial AssistantARCHIE LIEBERMAN, Art EditorWRIGHT ADAMS ROBERT J. HASTERLIKRICHAllD K. BLAISDELL ELEANOR M. HUMPHREYSL. T. COGGESHALL HUBERTA LIVINGSTONERICHARD EVANS PETER V. MOULDERWALTER L. PALKER HODGESRobert D. Moore is Secretary of theAssociation. Dr. Moore, who receivedhis M.D. degree in 1939 from the Univer­sity of Buffalo, first came to the Univer­sity as a resident in 1941 and remainedon the faculty until 1948. He rejoined usin 1958 and is now professor of ortho­pedic surgery.Henry L. Wildberger, '51, is Treas­urer. He took his internship and resi­dency here and remained in the Depart­ment of Medicine until 1962. He is nowassistant professor of medicine at North­western University and is on the attend­ing staff of Chicago Wesley MemorialHospital.Elected to three-year terms on thecouncil were:Joseph P. Evans, Harvard '29, pro­fessor of neurosurgery. Dr. Evans in­terned here and returned in 1954 tobecome head of the section of neuro­surgery.William J. Hand, '43, chief of medi­cal services at Illinois Central Hospitaland clinical assistant professor at theUniversity of Illinois.FACULTY AWARDSJosef Fried, Ben May Lab and Bio­chemistry, and Benjamin Spargo, '52,Pathology, received U.S.P.H.S. ResearchCareer Awards this year as did John R.Platt -and Robert B. Uretz, Biophysics.Lawrence Bogorad, Botany, has heldthe award for two years and HerbertLandahl for three. The awards providesalary support which may be renewedannually during the research career ofthe applicant.