th J"'e�icinee Mldwa}/:-----Bulletin of th 0The Uni 0 e Medical Alum 0no 0 0 versity of Ch 0 DI Associatiorvrsion of th BO icago nTh e 1010 0e Pritzker Sch gical Sciences001 of Medi 0icmeoCover: Returning to the Midway. This issue of Medicine on the Midwaycommemorates the , 979 Medical Alumni Day and gives coverage offeatures such as the Distinguished Service Awards, University AlumniAwards, and the Senior Scientific Session. (Pictured is an aerial view of theMidway with balloons by Peter Miller.)HOSPITAL HIGHLIGHTS$70.2 MILLION !10DERNIZATION PLANNED .••On Tuesday, April 17, theUniversity announced plans for a five-year $70.2 million program ofmodernization of its hospitals and.clinics. The program was announced byHanna H. Gray, President of the University.The program includes the proposed construction of a 500-bedfacility that will replace aging patient care and support units nowscattered throughout the University's medical center.The 500 beds which will be replaced by the new facility include!virtually all the beds in Billings H6spital (opened in 1927) and ChicagoLying-in Hospital. These are the two oldest structures among the 12buildings in the medical complex.A new Chicago Lying-in will become an integral part of the newhospital structure. The 98 beds in Wyler Children's Hospital (opened in1967), 97 beds in the Clarissa C. Peck Pavilion of Billings Hospital(opened in 1961), and the 8 intensive care and 18 acute care beds in thenew Surgery-Brain Research Pavilion (opened in 1977) will remain intact.The University's medical center now has a total of 721 beds,and the beds in the new facility will not increase the total bed capacity.The annual patient volume at University Hospitals and Clinics now totals23,000 admissions and 300,000 ambulatory patient visits.If approved by city and state health agencies, construction willbegin in July 1980 and take between three and four years to complete.Financing--Financing the program will come from three sources:$15 million through fund raising, $13 million in funds generated by thehospitals through operating efficiencies, with the balance to be made bylong-term borrowing.Dean Robert B. Uretz, Vice-President of the Medical Centeremphasized that funds would be generated without an increase in patientfees.Mrs. Gray said the $15 million in new funds would be included ina $25 million fund raising effort to begin shortly. The other $10 millionwill be sought for support of academic programs in the medical area andthe biological sciences, including teaching, research and studentfacilities. She said there had been consideration of a more llmitedprogram of renovation of existing facilities at a cost of $55 million, butit was decided that a new facility would provide modern hospital spaceoffering greater flexibility for change without increasing the size ofthe medical center�HOSPITALS RECEIVE HIGHEST RATING •.•The University of ChicagoHospitals and Clinics (UCHC) received a two-year accreditation from theJoint Commission on Accreditation of Hospitals (JCAH).A two-year accreditation is the highest approval ratinggranted by the independent, national hospital accrediting agency.Included in the evaluation are Billings Hospital, Chicago Lying-inHospital, and Wyler Children's Hospital.This means that the Hospitals and Clinics meet or exceedstandards set for in-patient services, clinics, and up-to-date buildingsafety codes according to the accrediting agency."We are proud that the JCAH has recognized our accomplishmentsin improving facilities and services in recent years to qualify for atwo-year rating. This further motivates our dedication to other taskswe face," said David Bray, Associate Vice-President for the MedicalCenter and Executive Director of the Hospitals and Clinics.UCHC received a third consecutive one-year rating by JCAH inOctober 1977. At that time the Joint Commission representatives pointedout that improvements had to be made in the Medical Center's fifty-yearold physical plant, that documentation in patients' medical records hadto follow standard practice more closely, and that medical stafforganization had to be structured to provide for quality assurancereviews. Corrections or substantial progress toward solutions to these'problems were the first steps which led to the two-year rating.New governance by-laws wereapproved and are now in effect at the University of Chicago Medical Cent�r.The by-laws were developed to establish policies for self­regulation by the medical staff and to ensure the maintenance of highstandards of professional practice. They also formalize medical staffparticipation in the development of hospital policy."These by-laws mandate a revamped Medical Staff Organization(MSO) which will make it possible for our practitioners to have moreinput in the operation of the institution," says Dr. Donald Benson ('50),Professor and Chairman of the Department of Anesthesiology, who headedthe medical staff committee in charge of researching and drafting thenew by-laws.The MSO is comprised of all physicians, dentists, and podiatristswith clinical privileges at the Medical Center.HSO elected officers are: Dr. George Block, Professor,Department of Surgery, president; Dr. Charles S. Winans, Professor,Department of Medicine, vice-president; Dr. E. H. Uhlenhuth, Professor,Department of Psychiatry, counselor; Dr. John F. Robinson, Professor,Zoller Dental Clinic and the Department of Surgery, counselor; and Dr.Francis Straus, Professor, Department of Pathology, and AssociateDirector of the Surgical Pathology Lab, secretary.Quality Control--A Quality· Control Committee is provided forby the new by-laws that will monitor and evaluate the quality of patientcare. It includes several sub-committees: Utilization Review, which willevaluate the appropriate use of medical facilities and services; MedicalAudit, created to evaluate the quality of clinical services provided inthe Hospitals and Clinics based on peer-established standards of practice;Medical Records, which will review the thoroughness of patient recordkeeping; Tissue Review, designed to review pathologic reports of alltissue specimens received as a result of surgical procedures; PhysicianCredentials and Privileges, which will ensure compliance with standardsof eligibility for staff appointments and privileges; and PatientIncidents, to investigate unusual occurrences involving patients.--John Costopoulos, TABLETSELF-REGULATION MOVES FORWARD ...Bulletin of the Medical Alumni AssociationThe University of ChicagoDivision of the Biological SciencesThe Pritzker School of MedicineVol. 34, No.1, Summer 1979Editors: Janice Schmidtand Christina West WellsPhotographs: Mike Shields,John Wells, Chuck Bloom,and Barbra ArmaroliChairman, Editorial Committee:Robert W. Wissler C 48)Medical Alumni AssociationPresident: Frank W. Fitch ('53)President-elect: Louis Cohen ('53)Vice-President: Peter Wolkonsky:('52)Secretary: Randolph W. Seed ('60)Director: Katherine Wolcott WalkerCouncil Members:Fredric Coe (,61)Herbert G. Greenlee (' 55)Abbie R. Lukens (' 50)Robin O. Powell (' 57)Julian J. Rimpila ('66)Francis H. Straus ('57)Copyright 1979 by the MedicalAlumni AssociationThe University of Chicago on Medicinethe Midway6 31Alumni Celebrate Annual Reunion A Close Encounter with FameDr. Henry R. Jacobs16 35Distinguished Service AwardPresentations Medical Student in There PitchingLynn Sweet20 36Research, Reform, and RealityDr. Richard H. Moy ('57) Residency Assignments 197923 38Alumni Elect New Officers News Briefs and In Memoriam24 39China: At Home in PekingDr. Edwin J. DeCosta ('29) Departmental News26 42Alumni NewsUniversity Alumni Awards29 46Focus on Pulmonary Medicine Abstracts of the Senior ScientificSessions5More than 500 medical alumni and guests attended thereception and dinner honoring the Class of 1979 at theDrake Hotel in Chicago, June 14.The dinner highlighted a two-day medical alumni re­union at the Midway campus June 14 and 15. Both stu­dents and faculty were presented with awards at the eve­ning ceremony which ended with musical selections fromthe Senior Skit.Outgoing president of the Medical Alumni Association,Dr. Joseph H. Skom ('52) presided at the dinner and Dr.Clifford W. Gurney ('51) administered the HippocraticOath to some 100 medical students in this year'sgraduating class.Beginning with a class chairmen's breakfast meeting at7:45 a.m. June 14, the reunion activities included a con­tinuing medical education program-Frontiers ofMedicine-on newer concepts in practical cardiology andprogress in cancer management, and a presentation ofpapers by the five 1979 Distinguished Service Award re­cipients.Reunion classes held class dinners both on and offcampus, and an awards luncheon was hosted July 15 inSwift Hall during which the Distinguished Service6 Alumni CelebrateAwards and 50-Year Citations for the Class of 1929 werepresented.Chairmen's BreakfastHospital administrators addressed a breakfast gather­ing of class chairmen at the Quadrangle Club June 14.David Bray, Associate Vice-President for the MedicalCenter and Executive Director of the Hospitals andClinics, discussed plans for a five-year $70.2 million hos­pital modernization program. The program calls for reno­vation of existing areas as well as the construction of a500-bed replacement hospital."This is the biggest project we have initiated in thehistory of the Medical Center," said Bray, "and we be­lieve it will be a major factor in perpetuating the traditionof excellence at this institution."Medical Alumni Survey results and the Medical Cen­ter's response to problems identified therein, were ad­dressed by Jeff Goldsmith, Director of Health Plan­ning and Health Regulatory Affairs and Special Assistantto the Dean of the Biological Sciences and the PritzkerSchool of Medicine.In particular, Goldsmith cited the Medical Center's ac-Annual Reuniontions to improve its referral system. "In the service ofthis objective, we are developing a special office of re­ferral coordinator ... between our medical staff and thephysicians in the community seeking to refer us patients.We are developing a special pre-visit or pre-admissionmailer that ... will enable us to schedule the visit andconduct financial clearance before the patient arrives... [and] a special track for handling these patients andgetting them through our system expeditiously."The breakfast meeting closed with a "pep talk" byClass Chairman E. H. Given ('59) on the subject of fundraising. "The cost of private education, superior as it is,can no longer be sustained by outside endowmentsources and government funding with all its built-in con­trols," said Dr. Given. He suggested that supporting theMedical Center could, under the circumstances, beviewed as a "moral obligation to replace the cost of[one's] education."Alumni-Faculty Reception, LuncheonFive Distinguished Service Award recipients were pre­sented with their awards at a luncheon ceremony in SwiftHall June 15. University faculty and alumni introducedthe award winners, who are: • Dr. John R. David (,55), Professor, Department ofMedicine, Harvard Medical School;• Dr. Sanford B. Krantz (,59), Director, Division ofHematology, and Professor of Medicine, Vanderbilt Uni­versity School of Medicine, Nashville;• Dr. Charles Mittman (,60), Executive Medical Di­rector, City of Hope Medical Center, Duarte, California,and Associate Clinical Professor of Medicine at UCLA;• Dr. Richard H. Moy (,57), Professor of Medicine andDean and Provost, Southern Illinois University School ofMedicine, Springfield; and• Dr. George L. Nardi (,44), Professor of Surgery,Harvard Medical School, Visiting Surgeon, Mas­sachusetts General Hospital, Boston.Following the award presentations, eighteen membersof the Class of 1929 received fifty-year citations. Citedwere:C. Allen AlexanderCharles BaronSamuel BergerLeonidas H. BerryLibuse K. BlissHarry BrandmanGeorge D. Cannon Saul K. PollackRichard K. SchmittAbraham SchultzHarold C. VorisWilliam H. CartmellEdwin J. DeCostaWilliam S. HoffmanNorbert F. Leckband+Benjamin H. NeimanIrene A. NeuhauserPaul J. Patchen tDeceased7Dr. Catherine Dobson ('32) and winner of theDobson Prize, Paul Sternberg, Jr.Research and teaching awardees, from left, re­spectively, Steven Burres and Charles Strom.Standing, from left, Dr. Cornelius Vander Laan(,44), Dr. Thomas Vander Laan ('79), and Mrs.Cornelius Vander Laan.8 Class of 1944 at the Medical Alumni Dinner.Members of the class of 1949, from left, Dr. Janet Rowley, Dr. Mary Carroll(class chairman), and Dr. Ernest Siegried.-..; . .."Class of 1969 at the Chicago Yacht Club.Members of the class of 1929, front row, left: Drs. Charles Baron, Paul Patchen, Benjamin Neiman, Abraham Schultz, Libuse Bliss, LeonidasBerry, and Irene Neubauser. Back row, left: Drs. William Hoffman, Samuel Berger, C. Allen Alexander, Harry Brandman, Saul Pollack, EdwinDeCosta, Nobert Leckband (deceased), Richard Schmitt, George Cannon, and Harold Voris.Members of the class of 19S4 holdenlarged senior year class composite.Medical Alumni Day '79Class of 1959 at the Chicago Yacht Club.9Senior students receive named awards, from left,Walter Koroschetz, Stephen Nimer, Ewald Hor­wath, judith Banks, joel Howell, and William Elliott.Medical Alumni Reception, DinnerAt an evening reception and dinner honoring the Classof 1979 held at the Drake Hotel June 14, the outstandingachievements of students and faculty members were rec­ognized.Awards to GraduatesAmerican Medical Women's Association Awards, towomen medical students for scholastic achievement,were made toJudith Rae BanksAnne H. Brenner Kathryn Lee RiceJoan Frances Polyak Wright.Joseph A. Capps Award, to a Senior medical student forproficiency in clinical medicine, was made toStephen David Nimer.Catherine Dobson Prize, to a Senior for the best oralpresentation of research done by a non-Ph.D. student,was awarded toPaul Sternberg, Jr.Dr. Harold Lamport Biomedical Research Award, for thebest dissertation in Biomedical Research, was made toWilliam John Elliott.Franklin McLean Medical Student Research Award, to aSenior who has performed the most meritorious research,was made toSteven Alan Burres.Medical Alumni Prize, to a Senior for the best oral pre­sentation of research done in medical school, wasawarded toRoger Philip Holland.John Van Prohaska Award, for outstanding potential inteaching, research, and clinical medicine, was made toCharles Martin Strom.10 Dean Robert B. Uretz, center, congratulates Dr. Henry DeLeeuw ('47), atleft, and Dr. julian Rimpila ('66) after the class chairmen's breakfast June14. Dr. DeLeeuw headed the class with greatest participation in alumnigiving (56 percent), while Dr. Rimpila's class showed the greatest im­provement in participation (from 32 to 47 percent). Not pictured is Dr.joseph Baron ('62), whose class made the greatest contribution.Richard W. Reilly Award, to a Senior medical student foroutstanding aptitude in the field of Gastroenterology, wasmade toJoel Dubose Howell.Sandoz Pharmaceutical Award, in recogmtion of out­standing performance in the field of Psychiatry, wasmade toErwald Horwath.DeCarr Covington ('79), at left, presents the Hilger Perry Jenkins Award toDr. Eugene Chang.Mary Roberts Scott Memorial Prize, to a woman medicalstudent for academic excellence, was awarded toJudith Rae Banks.Nels M. Strandjord Memorial Award, to a Senior medicalstudent for outstanding performance in the general fieldof Radiology, was made toRoger Philip Tokars.Upjohn Award in Medicine, to a Senior for outstandingachievement during four years in medical school, wasmade toWalter Joseph Koroshetz. Seniors graduated with Honors were:1. Davis Allan, Jr.Rick Anthony EspositoRobert Paul GaynesRoger Philip HollandJoel Dubose Howell Walter Joseph KoroshetzStephen David NimerPaul Sternberg. Jr.Charles Martin StromRobert Michael SwiftSeniors elected to Alpha Omega Alpha were:J. Davis Allan, Jr.Judith Rae BanksAnne H. BrennerJames L. BuddDeCarr Dowman Covington IIIRick Anthony EspositoJohn Humphrey JacobsonJoseph Patrick KiernanWalter Joseph KoroshetzFrank Scott Lieberman Anne' Rachel MittelstaedtAllan Steven NadelStephen David NimerKathryn Lee RicePaul Sternberg, Jr.Charles Martin StromNeil Stuart WeintraubCharles Allen WittnamJoan Frances Polyak WrightAwards to FacultyThe Gold Key of the Medical Alumni Association waspresented to Dr. Joseph B. Kirsner (Ph.D. '42), the LouisBlock Distinguished Service Professor, Department ofMedicine at the University of Chicago.Dr. Kirsner, a renowned gastroenterologist with anoutstanding clinical reputation, joined the faculty of theUniversity in 1939 as Instructor in Medicine. He receivedhis medical degree from Tufts University School ofMedicine in 1933 before coming to the University ofChicago where he completed a Ph.D. in Biological Sci­ences in 1942.From 1935 to 1939, Dr. Kirsner was Assistant inMedicine. He became an Assistant Professor in 1942, As­sociate Professor in 1947, and Professor of Medicine in1951. In 1974, he was named the Louis Block Distin­guished Service Professor of Medicine.Dr. Pierce Gardner (right) receives the McClin­tock Award. Winners of the AMWA award, from left, Joan Wright, Kathryn Ross, Anne Brenner, and JudithBanks.11.� �.'�Dr. Joseph Skom ('52), at center; Dr. Harriet Skom Meyer ('79), at his left; Mrs. Joseph Skom;and Dr. Ronald Meyer (79).Dean Joseph /. CeithamlThe author of more than 500 publications dealing withvarious clinical and research problems in gastroenterol­ogy, Dr. Kirsner has also trained more than 200 graduatestudents in gastroenterology and in addition, maintaineda very active, widely renowned clinical service at theMedical Center.Dr. Walter L. Palmer (,21, Ph.D. '26), the Richard T.Crane Professor Emeritus, Department of Medicine atthe University of Chicago, presented Dr. Kirsner withthe Gold Key award. "Joe and I have travelled togethermany long and weary miles, but always with joy," saidDr. Palmer. "This key is symbolic of our [Medical Alumni's] pride in him and of our hope that, as he jour­neys through the years ahead, the road's last turn will bethe best."The McClintock Award, for outstanding teaching,voted by the graduating class was presented to Dr. PierceGardner, Professor in the Departments of Medicine (In­fectious Disease) and Pediatrics, and Director of MedicalHousestaff.The Hilger Perry Jenkins Award, given by thegraduating class for excellence in performance ofacademic and patient service, was presented to Dr.Eugene Chang, Resident in the Department of Medicine.Alumni and guests at the awards luncheon in Swift Hal/June 15.12Dr. Joseph B. Kirsner (Ph.D. '42), right, receives the Cold Key of the Medical Alumni Associa­tion from Dr. Walter Palmer ('27, PhD. '26).Reunion ClassesMembers of the Class of 1944, 1949, 1954, 1959, 1969,and 1974 celebrated reunion years along with housestaffof 1953-1954. Alumni attending were:Class of '44Frank F. EvansJames L. FreyDavid S. Fox, ChairmanPeter L. GiovacchiniGeorge L. NardiMedical Alumni Dinner7979 and awards presenta­tions in the Cold CoastRoom, Drake Hotel,Chicago. Morton Lee PearceAlan RobertsonCornelius A. Vander LaanRobert WeaverMembers of the Class of 1929 stroll through the Quadrangles. Members of the Class of 1929, Dr. George D. Cannon (left) and class chair­man Dr. Paul Patchen, confer over lunch.Class of '49Joseph P. ArcomanoCharles R. BaconMary E. D. Carroll, ChairmanRobert M. DowbenBurton J. Grossman William E. HummelJanet D. RowleyErnest C. SiegfriedNancy E. WarnerJames W. CrawfordA. C. DillerThomas DutcherDonald A. FaulknerLeonard V. FisherCharles F. JohnsonJames KeaslingDavid Rosenberg Class of '54Lois A. G. ScheimannCharles M. ShapiroGordon S. SiegelRichard G. ThompsonVerner S. WaiteDorothy Windhorst, ChairmanNicholas T. Zervas«bov« from right, Dr. Boris Schuster ('37), Mrs. Boris Schuster, Dr. Gary Schuster ('79), and Mrs.:ary Schuster. At right, alumni and guests gather for the awards luncheon in Swift Hall June 15.14Cross anatomy scene from Senior Skit 7979.James R. DahlRichard Evans Class of '59Sanford KrantzColeman SeskindFred ShusterDavid M. Terman Daniel R. CoopermanRobert E. DinsmoreEdwin C. DouglassJohn Gallagher, ChairmanPamela GallagherRoyce Oliver Johnson II Class of '74Thomas T. KubotaEdward S. LinnJames SchulakNathan M. SzanbergAnne B. WardRobert L. WhiteEverett H. Given, ChairmanMorton H. GoldsteinWalter KahnClass of '69Andrew J. Aronson, ChairmanDavid A. CookSteven GoldsteinFranklin Kozin Michael 1. O'NeillEdward PesantiWilliam WeeseLaurens D. Young Housestaff Interns' 53Robert LevineEdward LyonLouis CohenRobert EnglandRobert HarrisonRight, medical ethics scene and, below, gross anatomy scene from SeniorSkit 7979.15Five Men:Presentations of the 1979 Distinguished Service Awards by Faculty & AlumniDr. John R. David ('55)It is hard, living as we do in the present golden age of im­munology, to remember how recently the key role of thelymphocyte was recognized. Only two decades ago, ProfessorTrowell concluded a review article on the lymphocyte with thefollowing words: "The small lymphocyte seems a poor sort ofcell, characterized by mainly negative attributes .... It must be. regretfully concluded that the office of this Cinderella cell is stilluncertain." What Professor Trowell did not know was thatwithin a half dozen years, several different kinds oflymphocytes would have been identified, and that a number ofPrinces Charming would appear with glass slippers fitting thesedifferent lymphocytes.Dr. John David, whom we honor today with a DistinguishedService Award, was one of the first Princes to appear on thescene. A writer of fiction would have difficulty providing hishero with a more exciting background. John was born in En­gland. He graduated from Hollywood High School. His fatherwas a writer-director in motion pictures.John came to the University of Chicago for his undergraduateeducation, and by the time he entered our Medical School, hehad completed a children's book, won a short story contest, andmade Phi Beta Kappa. During medical school, he worked withNobel Laureate Konrad Bloch on cholesterol biosynthesis, andadded junior year election to Alpha Omega Alpha to his list ofhonors.John was awarded the M.D. degree from the University ofChicago in 1955, but he forsook Chicago for the MassachusettsGeneral Hospital for an internship and residency in internalmedicine. He interrupted his residency first to serve as a clinicalassociate at N .I.H. and then in the Rheumatism Research Unitat Taplow, England. He went to New York University in 1961for further fellowship training.His interest in immunology, kindled by his experience atN.I.H. and in England, flourished at N.Y.U. Lew Thomas,more recently known widely for his literary pursuits, was thenthe chairman of the department of medicine and a remarkablystimulating internist and immunologist. Thomas had a knack forrecognizing important phenomena, and he gave John the prob­lem of working out the details of a promising but often notreproducible method suggested by other investigators forstudying delayed-type hypersensitivity in vitro. Johnestablished a reliable technique and used the system to showthat macrophages present in peritoneal exudates of sensitizedguinea pigs did not migrate if the sensitizing antigen was addedto the culture. He demonstrated that this immunologically­specific effect required the presence of sensitized lymphocytesand did not relate to antibody responses.These were interesting and important observations, but thereally significant breakthrough came in 1966 when he showed16 Dr. John R. David ('55)Topic: "Mechanisms of Cellular Immunity: Lymphocyte Mediators andActivated Macrophages"that this effect was mediated by a soluble factor released fromsensitized lymphocytes exposed to the antigen with which theyreact. Migration Inhibitory Factor, or MIF as it came to becalled, was the means by which lymphocytes could influencethe activities of other cells. This was a key observation inunderstanding the inflammatory response associated withdelayed-type allergic reactions and provided the basis for otherstudies that revealed the existence of additional factors pro­duced by lymphocytes.John moved back to Boston in 1966, joining the staff of theRobert Breck Brigham Hospital and the faculty of HarvardMedical School. He was promoted to professor there in 1973.He and his associates have continued to make major contribu­tions to the unravelling of the complexities of allergic in­flammation. He told us this morning about his studies on theinteractions between lymphocytes and macrophages and abouthis recent interest in the peculiar role of eosinophils in parasiticinfections.Present day reviews of lymphocyte functions present a verydifferent message from that of Trowell's. Lymphocytes carryout their effector functions in a variety of ways, many of whichinvolve the release of mediator factors such as MIF. It is for hispioneering and continuing efforts in characterizing this impor­tant biological process that we honor Dr. John Rouben Davidwith the Distinguished Service Award of the Medical AlumniAssociation.Dr. Frank W. Fitch ('53)Dr. Sanford Krantz ('59)It is a pleasure to welcome Sanford Krantz back home. Dr.Krantz is a product of the University of Chicago in its purestform and in its best tradition. He graduated from our college in1955 and our medical school in 1959. He served his internship,residency, and a postdoctoral fellowship in our Department ofMedicine.Deciding to make a major commitment to the study ofhematopoietic tissue in tissue culture, Dr. Krantz went to theUniversity of Glasgow to study for a year and master tech­niques utilized in the laboratory of Dr. John Paul, one of theworld's leaders in the in vitro study of bone marrow. Dr. Krantzthen returned to the University of Chicago as Assistant Pro­fessor, Department of Medicine in 1965. Following two years atthe Clinical Center of National Institutes of Health as assistantchief of hematology, he joined the faculty of Vanderbilt U niver­sity in 1970. He is now professor of medicine and director ofhematology at that institution.Dr. Sanford B. Krantz('59)Topic: "Pure RedCell Aplasia"Dr. Krantz's record in basic and clinical research can best besummarized as spectacular. Working initially with Dr. EugeneGoldwasser of our Department of Biochemistry, he participatedin the exciting series of investigations that elucidated thebiochemical mechanisms of action of the hormone eryth­ropoietin in the regulation of red blood cell formation. Hisstudies on the unique functional characteristics of the marrowof patients with polycythemia vera have afforded new insightsinto the pathogenesis of that disease. His investigations of pa­tients with pure red blood cell aplasia have elucidated clearlythe immunological nature of that affliction and have demon­strated the remarkable therapeutic effectiveness of im­munosuppression.Currently, Dr. Krantz is pursuing basic studies of cellulardifferentiation and transformation by viruses and endotoxinwhile simultaneously conducting a wide variety of clinicalstudies in lymphoma and drug-induced toxicity.This Distinguished Service Award is presented today in re­cognition of the outstanding record of leadership in academicmedicine and the monumental nature of contributions in basicbiology and clinical medicine from one of our most illustriousgraduates, Dr. Sanford B. Krantz.Dr. Clifford N. Gurney ('51) Dr. Charles Mittman ('60)It is my pleasure and happy duty to introduce Dr. CharlesMittman, the Executive Medical Director of the prestigious Cityof Hope Medical Center near Los Angeles and associate clinicalprofessor of medicine at UCLA.How does one properly introduce a recipient of this awardother than to recite a list of accomplishments and present ac­tivities and still hope to tell someone about the man') In myremarks I will mention only a minimum of "facts" but willrather try to introduce Dr. Mittman to you in a way that will tellyou something about him not only as a scientist but as an ad­ministrator, husband, father, and person.If I were to try to describe Dr. Mittman in a single word, theword I would choose would probably be versatility.Dr. Charles Mittman came to the University of Chicago as anundergraduate. He received his B.A. degree in 1956, B.S. de­gree in 1957, and his M.D. in 1960-all with honors. His post­graduate training was done at the University of Chicago and theJohns Hopkins University in Baltimore.Among the many clinical and research societies to whichChuck belongs are, briefly, Alpha Omega Alpha, Sigma Xi, andthe American Thoracic Society. He is a Fellow of the AmericanCollege of Chest Physicians. He is on the editorial board ofChest, and served in 1976 as the editor of The Teaching Pro­gram in Chronic Obstructive Lung Disease of the AmericanCollege of Chest Physicians. Dr. Mittman served on manyCalifornia Lung Association committees as a member andofficer and on many federal government agency advisory com­mittees including the Environmental Protection Agency and theNational Institutes of Health.He has published often, participated in numerous symposia,and given many lectures as a world authority in pulmonarydisease, pulmonary biology, and biochemistry.My association with him of late has been due to his contri­butions in the field of environmental health. He has conductedmajor investigations using the large work force of my nearbyKaiser Steel plant in California as a cohort for studies in lungdisease. His work there has involved alpha, antitrypsin as apossible contributing factor in emphysema and determiningwhether the disease is perhaps genetically preordained. In ad­dition, he has done and is doing large studies on the incidence ofother lung diseases such as bronchitis, asthma, and lung cancerin a work population. All this is the stuff of scientific endeavorwhich leads a great university to bestow an honor upon one ofits own.Chuck Mittman, the man, married his grade school class­mate, Eileen. They now have four sons, all of whom show greatpromise of following in the path of their dad's academic excel­lence. Scott just graduated from Harvard with Phi Beta Kappahonors and intends to pursue a career in medicine. Brian hasjust completed his second year of engineering at Princeton.Jeffery and David, their two younger sons, are currently in highschool but share a record of academic excellence.As for pastimes, Chuck was an organizer of our dailylunch time bridge games back in the good old days of medicalschool. One of my classmates, Jim Dahl, remarked that he ex­pected that as we were walking down the hall toward P-117 tohear Dr. Mittman give his paper today, that he fully expectedChuck to grab him and pull him into the student lounge acrossthe hall for a game of bridge.17Dr. Charles Mittman ('60), at left, receives award from Dr. E. H. Given('59).Topic: "Genetic Aspects of Lung Disease"I wouldn't want you to think that Chuck is perfect. He doeshave at least a couple of bad habits-he seems to like exerciseand worst of all, jogging. In addition, he smokes terrible­smelling cigars and/or a pipe, that is, if he is successful in avoid­ing his secretary, Doris, who relegates him to broom closets andsmall conference rooms at the first whiff.Mentioning his secretary brings to mind his current activitiesas Executive Medical Director of the City of Hope research andclinical hospitals in California. After many fruitful years of re­search and the practice of clinical medicine, he assumed ad­ministrative duties, first as director of the City of Hope re­spiratory disease department and later as assistant medical di­rector under Rachmiel Levine, and now as the executive medi­cal director.The City of Hope is a most remarkable medical center and Iam sure most of you are aware of their recent elegant work,widely publicized, involving the production of human insulin bybacteria following insertion of synthetic human insulin genes forboth the A and B chains. I am sure it is fair to say that as muchas he enjoys administrating for the City of Hope he probablyequally misses his clinical and research duties which have hadto suffer some due to lack of time. How he finds time, in addi­tion, for his photographic avocation and doing yard work athome in Arcadia is beyond me.Dr. Mittman's life style could probably be exemplified best bythe word peripatetic as exemplified by an ancedote told merecently by his secretary:Dr. Mittman was dashing about his office tying up loose endswhile trying to leave for a meeting. As he bolted out the door headvised his office staff, "You know where I'll be." Secondslater the door opened, he popped his head in, and asked plain­tively, "Where will I be?"It is my great pleasure to introduce our honoree for the Dis­tinguished Service Award of the University of Chicago-Dr.Charles Mittman.Dr. E. H. Given ('59)18 Dr. Richard H. Moy ('57)Dr. Richard H. Moy is a Chicago-area product through andthrough. He was born in Chicago and he went to publicelementary and high schools in nearby Naperville, Illinois, be­fore he entered the College of the University of Chicago in thefall of 1949.I have personally known Richard Moy since the fall of 1953when he entered our medical school. He is, indeed, a multiplealumnus of the University of Chicago. He received his B.A.degree with honors from the College in 1953. Then after finish­ing his first year of medical studies on campus, he received hisB.S. degree. In 1957 he received his M.D. degree in Pathology,again with honors, and in recognition of his excellent perform­ance in his clinical work he was elected to Alpha Omega Alpha,the honorary medical society.While in medical school he participated extensively in re­search and was elected to Sigma Xi in recognition of his ac­complishments. After graduating from our medical school,Richard Moy stayed on to do his internship at Albert MerrittBillings Hospital. Following that, the string was broken for twoyears, from 1958 to 1960, while he was a clinical associate inendocrinology at the National Institutes of Health in Bethesda,Maryland. That, however, proved to be but an interlude for hecame back to the University of Chicago to do a three-year res­idency in medicine.Dr. Richard H. Moy('57)Topic: "Research,Reform, and Reality"For the next five years Richard Moy was a fellow and thenResearch Associate in the Department of Medicine at the Uni­versity of Chicago. It was during this time that he became Di­rector of the University Health Service-a post he held for sixyears, achieving the rank of Associate Professor in Medicine­before leaving the University to become the first Dean of theSchool of Medicine of Southern Illinois University inSpringfield, Illinois. He assumed that position in January 1970and he still retains it, an accomplishment in itself since thehalf-life of deans of medical schools these days is less than fouryears.In his capacity as Dean of the Southern Illinois UniversitySchool of Medicine, he participated actively in planning thephysical plant and the design of the school's three-year cur-riculum. It is significant that Richard Moy with his extensiveexperiences in research and speciality training had the versatil­ity to successfully establish a medical school which has as itschief mission the production of physicians who intend to engagein primary care practice and to a great extent in rural areas.At the present time, Richard Moy is both dean and provost,as well as professor of medicine at the Southern Illinois Univer­sity School of Medicine. The school currently admitsseventy-two students each year into its entering class, and morethan anyone else, Richard Moy has been responsible for theconsiderable success that that medical school has alreadyachieved.Not only has Richard Moy proved himself to be an excellentclinician and medical scientist, a capable administrator and asuperb medical educator, but he is also a very fine human being.A sensitive, kind, and personable individual, he also possessesa strong sense of responsibility and loyalty and a keen sense ofhumor. He is recognized as one of the leaders in medical educa­tion, and he holds the respect and the confidence of his col­leagues. By his achievements and activities, he is a great creditto the University of Chicago and even more so to humanity.Richard Moy , I am pleased to present to you our MedicalSchool's Distinguished Service Award.Joseph J. Ceitharnl (Ph.D. '41)Dr. George L. Nardi ('44)If our gathering today was comprised primarily of surgeons, therecipient of the 1979 Distinguished Service Award, Dr. GeorgeL. Nardi, would need no introduction. Dr. Nardi is a householdname to the international surgical community, and surgeonspracticing such varied disciplines as abdominal, endocrine,thoracic, vascular, and trauma surgery have recognized hismany contributions and have honored him by election to theelite surgical societies, by visiting professorships, and a host ofhonorary memberships and lectures.Dr. Nardi was born in Bologna, Italy, of American parentsand received both his Bachelor of Science and Doctor ofMedicine degrees from the University of Chicago. This latterdegree was conferred in 1944. One year prior to graduation, Dr.Nardi's scholastic excellence was recognized by election to theChicago Chapter of Alpha Omega Alpha. Of particular interestto Chicago chauvinists is the first citation in Dr. Nardi's list ofpublications: a report with the late, beloved Hilger Jenkins onthe control of hemorrhage by a gelatin sponge material-nowknown to all surgeons as Gelfoam, This report appeared inSurgery in 1947 and was the first of what is now a prodigiousbibliography totaling 150 scientific articles, books, and mono­graphs.From Chicago, Dr. Nardi transferred his talents to Bostonwhere he served his internship and surgical residency inter­rupted by tours of active duty in the Medical Corps of theUnited States Navy in 1945 and again in 1954, Aside from hismilitary assignments, Dr. Nardi has remained a Bostonian andhas progressed up the academic and clinical ladder at Harvardand the Massachusetts General Hospital where he was namedprofessor of surgery in 1973.While Dr. Nardi's contributions to surgery and biology areprotean and embrace practically all organ systems and surgicaldisciplines, he is best known to surgeons throughout the world Dr. Ceorge L. Nardi (,44)Topic: "Saving the Islets of Langerhans"for his basic contributions to operations upon the pancreas andfor his identifications of the exocrine malfunctions of the pan­creas in various disease states and for his operative correctionsof these abnormalities. He is recognized today as the world'sleading authority on pancreatic surgery. Dr. Nardi's contrib­utions to the field of pancreatic surgery have taken this organfrom a surgical no-rnans-land and placed it within the surgicalarena.Listing his honors, memberships in learned societies, and hisinvited lectures and presentations would alone fill this after­noon's program. A few of these are memberships in AlphaOmega Alpha, American Association for Thoracic Surgery,Royal Society of Medicine, Society for Surgery of theAlimentary Tract, American Surgical Association, New En­gland Surgical Association, The Halsted Society, James EwingSociety, and honorary memberships in the Surgical Societies ofBolivia, Argentina, Milan, Lyon, and Dallas.Dr. Nardi has served as vice-chairman of the American Boardof Surgery, the Credentials Committee for the American Boardof Surgery, is a member of the editorial boards of Surgery andVideo-Surgery, and has accepted visiting professorships atDuke University, Ohio State University, The University ofUtah, University of Louis Pasteur, and The Surgical Institute ofWarsaw of the Peoples Republic of Poland.Superceding Dr. Nardi's scientific achievements are the rep­utation and character of the man. "A warm and outgoinghuman being," "a raconteur" whose humility and grace areextended to the neophyte surgeon as well as the senior clinician;"respected by his peers, admired by his students, and loved byhis patients": these are but a few of the responses to my in­quiries regarding Dr. Nardi. While scaling the heights of hisprofession, he has also accomplished what so often escapes thegreat: he is a successful and fond father and a beloved husband.Mr. Chairman, our honoree today has distinguished himself,the University of Chicago, and the surgical profession by hispersonality, his character, and his achievements. It is my plea­sure to present to you a renaissance surgeon as the recipient ofthe 1979 Distinguished Service Award from the University ofChicago: Dr. George L. Nardi of Boston and Chicago.Dr, George E. Block19Research, Reform, and RealityDr. Richard H. May ('57)While the tradition of research goes back, with great re­spectability, for many, many years, it burst forth withspectacular vigor and support following World War II.The dramatic example of the Manhattan Project, alongwith other important breakthroughs such as jet propul­sion, antibiotics, and space travel created great expecta­tions in the minds of the public and their elected officialsas to what could be accomplished by supporting scienceand technology. With an example like the Manhattan. Project, it was anticipated that enough dollars wouldcertainly bring answers in a reasonable period of time.When I was a clinical associate at the National In­stitutes of Health, I remember, vividly, hearing my chiefdiscuss the quandary he was in trying to figure out how hecould spend all the money Congress was forcing uponhim. The Sunday supplements, during the late 1940s and1950s, were regularly filled with great discoveries thathad been made or, more usually, those which were aboutto be made.Bountiful DollarsEarly in this era, during the Truman administration, aproposal to begin direct subsidy of medical education bythe federal government was beaten down primarily byorganized medicine. An alternative was conceived thatrode the crest of the national interest in research. Boun­tiful federal dollars supported construction, equipment,training, and salaries-always in the name of research.A tremendous dollar pressure resulted that began tohave a dramatic effect on medical schools beyond in­fluencing the physical structure of new laboratories andBountiful federal dollars supported construc­tion, equipment, training, and salaries-alwaysin the name of research-and dramatically af­fected more than the physical structure of medi­cal schools.research wings. Perhaps more permanently, it influencedthe behavior and expectations of young faculty memberswho were entering their careers during this era. Thesefaculty are now in most of the senior faculty positions inthe medical schools of this country.Research dollars, as the major economic driving force,also began to influence the rewards of the institutions. Bythe late 1950s and early 1960s, research productivity,with the visible accoutrements of publications and grants20 obtained, became the overwhelming consideration inpromotion, tenure, and salary decisions.It is not necessary to recount on the positive side themany valuable discoveries, contributions to knowledge,new drugs, procedures, and methods that resulted fromthis period. There was, however, progressive concerndeveloping in some quarters that at some point this av­alanche of funding for biomedical research could not besustained .In addition, the rather one-sided rewards and in­ducements to medical school faculty were beginning tohave the effect of decreasing concern over the quality anddelivery of health services outside centers of medicalIt was said by some during that era that medicalschools were fortunate their students were con­sistently so bright that they could learn medicinein spite of the faculty and curriculum.education. Even worse, there was dwindling concern forthe quality of the educational process itself. In fact, it wassaid by some during that period that medical schoolswere fortunate their students were consistently so brightthat they could learn medicine in spite of the faculty andthe curriculum.This brief and somewhat extreme recounting of a dra­matic recent era is intended in no way to downgrade theimportance of research as an important need for our soci­ety and an indispensable part of what makes up a medicalschool. It is intended to suggest that an era of enthusiasmand rather unquestioning support in our broader societyproduced profound changes in medical schools in thiscountry. Some of these changes were clearly for thegood, but in general they were unplanned, unbalanced,and unquestioned.A New EraDuring the early and middle 1960s, we began to enteran era of reform which continued through the mid 1970s.Here, also, the impetus came from our broader societygenerated primarily by two factors. One was the seriousincrease in restlessness in our northern cities amongminority groups, particularly blacks, and the other wasincreasing disenchantment and disillusionment with, andfinally rejection of our national participation in the Viet­namese War. This profound shaking of the middle classand its establishments by minorities and young peopleproduced an era in which all things could be subject toquestion and challenge. Research itself became highlysuspect as vocal spokesmen suggested that billions ofdollars had been consumed for the edification of thecareers of faculty members and precious little had gottenout to benefit the public, particularly in small towns andrural areas. This era gave broad permission for experi­mentation sociologically and legislatively.In terms of medical education, this motion in ourbroader society produced an environment in which it waspossible to conceive of new beginnings and innovationsin medical education that would simply not have beenpossible as a normal evolution of the previous era. Be­cause of the conservatism of medicine and medical educ­tion, if you wish to do something different, it is far easierto go off and start your own medical school than tochange an old one. Accordingly, while many of the ap­parent reforms were actually conceived by faculty mem­bers and staff people in traditional schools, they havebeen brought into existence most consistently and com­pletely in the new schools.Much of the activity of the newer medical schools,which has involved my career in the last ten years, re­ceived considerable support from Congress, state legis­lators, citizens, physicians, and hospitals who had feltthemselves sequestered from and neglected by the uni­versity medical centers. There was also support, thoughconsiderably less enthusiastic, from the American Medi­cal Association Council on Medical Education and theAssociation of American Medical Colleges. As with anyera of reform, there was a mix of necessary and reason­able corrections, over-corrections, and some strangelooking things that apparently sprang up on their own.Much of this was done midst a clamor of pietistic zealwhich I am sure was at times very cloying to theestablished institutions.Success AchievedWhile a final report has not yet been written on thecontributions of the new schools and reforms of the lastten to fifteen years, I think one could indicate wheresome successes are being achieved. Among the elementsof lasting value, I would suggest the reestablishment ofthe respectability of teaching and the realization that amedical school is, after all, primarily an educational in­stitution. Offices of medical education have beenestablished making competent use of the skills of educa­tional science in curriculum design, delivery and evalua­tion, providing more consistent and dependable rewardsfor excellence in teaching among the faculty. Thecompetency-based curriculum has evolved which, whereit is being applied, certainly seems to remove much of the frenetic and unnecessary competitive aspects of medicaleducation and provides a much more healthy and matureenvironment for learning.Another lasting generic contribution of the reform erais the reinvolvement with the practitioners and in­stitutions of "the real world." The community-basedschools, cutting themselves off from any hope of auniversity-owned and -operated hospital, have 'had towork out treaties that define what is really critical formedical schools to control and what is really not all thatnecessary to control. Expanding medical education byrelating to existing structures has saved hundreds of mil­lions of dollars in construction of unnecessary hospitalbeds. It has brought strength and depth to institutionsthat they could not otherwise have achieved. It has pro­vided medical students with a broader and perhaps morerealistic spectrum of models and presents to them anarray of diseases that are much more like those they willencounter in practice than the usual population of a uni­versity teaching hospital.A final, general, contribution of the reform era hasbeen the renewed respectability of interest in medicalsociology, medical economics, medical jurisprudence,A lasting generic contribution of the reform erais a reinvolvement with the practitioners and in­stitutions of the 'real world' by community­based medical schools cut off from universityaffiliation.and medical humanities. Actually these are ancient con­cerns of the profession that had come to be almost ig­nored. Inclusion of these domains in the objectives ofmedical education is critical, in my' judgment, for thecontinued success of medicine as a profession rather thanas a highly paid trade. It is also necessary from the edu­cational point of view, since the extreme and morbidpressures of the pre-med experience make it far too likelythat some of our finest and most intelligent young menand women will attend some of our greatest universitieswithout getting a college education. Since there is noconsistent way to correct this problem at this time, manyof us have gone to providing remedial liberal arts in medi­cal school and the results are very satisfactory.As in Hegel's historical progression, we can now seemany traditional schools beginning to celebrate thevalues of education and the social and humanistic aspectsof medicine, while the newer schools struggle to build upresources and attributes of scholarship and research.Thus the two great social thrusts of the past decades21appear to be heading toward a reasonable synthesis. Be­fore pronouncing the benediction "and they all livedhappily ever after," however, we had best take a look atthe emerging era of reality.From Watergate through Proposition 13, a new ele­ment of our society began to be heard. The great middleclass, which has been paying for the previous episodes,has begun to ask some extremely important and pointedquestions and is seeking a new accountability from itspublic officials and institutions. In trying to put togetherthe elements that will make up the social thrust of thecoming decade, I could not avoid the word "reality" be­cause there are too many evolving consequences thatsimply have to be confronted. This list includes deficitbudgets in peace time; continuing unemployment in theface of inflation; a dramatic decrease in the birth rate(raising the ominous question of who will pay the taxes todeliver on the promises made to those of us who aregetting older); the spreading of taxpayer revolts;grumbling of wealthy states in the face of federalbankruptcy; and finally, the painful increases in costs ofenergy.Change of MoodThe change of mood of the federal government, both inthe executive and legislative branches, has been dra­matic. We are, for example, still functioning under aManpower Act which called for five percent increase inenrollment to be able to get federal capitation funds. Thislast increase was accomplished over the protest of themedical schools. However, it was mandated by con­gressional leaders who demanded there still be moredoctors.The Act was hardly a year and a half old when Mr.Califano was stating there were too many doctors beingWe can anticipate difficult financial daysahead. Federal incentives will be withdrawn anda few medical schools, old and new, may simplygo bankrupt and close.produced and the new federal tenets for the support ofmedical education would call for a progressive reductionin overall numbers produced and particularly in certainspecialties of physicians. The executive branch has calledfor zero funding for capitation and certainly these fundswill be, at best, seriously cut, even though the studentswe were induced to admit are still in our schools.One can make certain predictions about the era of re­ality. In regard to education generally, we can anticipate22 difficult financial days ahead. Some poorly endowed pri­vate colleges and universities may well fold up. In thestates there will be calls for reorganizing, recombining,and reallocating physical and economic resources forpublic higher education. This will cause considerableclamor and disruption. As far as medical schools are con­cerned, we can anticipate almost all incentives will bewithdrawn for increasing or even maintaining the currentlevel of enrollment.A few medical schools, new or old, may simply gobankrupt and close, without further federal intervention.Exceptions will be those dedicated to minority groups.The country will support what research it can afford, butnever again will support be as bountiful and unquestionedas it was in the past. There is developing a new con­servatism in regard to experiments in medical education.Hopefully, those valid attributes I mentioned earlier willsurvive. Other experiments such as the three-year cur­riculum and the newer Veterans Administration medicalschools will have a very difficult road. Competition forsupport dollars will be intense. Just as medical schoolswere rediscovering the delightful possibilities of incomefrom the practice of medicine, they are seeing new reg­ulations and controls that will make that source of incomeperilous and leaving, particularly for the private schools,the painful alternative of dramatic increases in tuition.This era of reality will produce a sound buffeting for allof medical education. While it will be painful and at timesdistinctly unpleasant and there may be some unfortunatecasualties, it is also possible that some silliness and pom­posity can be shaken out and that medical schools mayemerge in the 1990s as more rational and better-behavedelements of our culture than they have been for sometime. One might even hope that the word "renaissance"could apply.Dark Age RealitiesIn the meantime we confront the dark age realities ofthe 1980s. In a discussion of these topics a year ago at theAssociation of American Medical Colleges Council ofDeans meeting in Snowbird, Utah, Lewis Butler, Pro­fessor of Health Policy at the University of California atSan Francisco, said that the upcoming events wouldleave medical schools like fragile sailboats manueveringaround in the fog with a strong tide running. In the dis­cussion period afterwards, Sherman Mellinkoff, dean ofthe medical school at University of California, LosAngeles, referred back to this metaphor saying that hereally wasn't terribly concerned about the other sail­boats, he knew their captains to be men of skill and honorand he was prepared to risk sailing with them. But whatreally troubled him was the diesel garbage scow comingout from Health, Education, and Welfare.Medical alumni officers, from left: Dr. Louis Cohen ('53), president-elect; Dr. Frank W. Fitch ('53), president; Dr. Joseph H.Skom ('52), immediate past president; and Dr. Randolph W. Seed ('60), secretary. Not pictured is Dr. Peter Wolkonsky ('52),vice-president.Alumni Elect New Officers,Seed to Head Annual DriveNew officers of the Medical Alumni Association wereelected June 14 at the annual alumni dinner held at theDrake Hotel in Chicago.Dr. Frank W. Fitch (,53), the Albert Lasker Professorof Pathology at the University of Chicago, was installedas president, succeeding Dr. Joseph H. Skom ('52).Other officers are: Dr. Louis Cohen (,53), Professor,Department of Medicine, University of Chicago,president-elect; Dr. Peter Wolkonsky (,52), Medical Di­rector, Standard Oil Company, vice-president; and Dr.Randolph W. Seed (,60), surgeon in private practice, sec­retary. Officers are elected for one- year terms.Dr. Seed has also been asked to assume a new positionin the Medical Alumni Association as director of the 1979Medical Alumni Fund. In this capacity Dr. Seed willoversee the Association's annual fund raising drive.New council members were also elected. They are: Dr.Fredric Coe ('61), Professor, Department of Medicine,Michael Reese Hospital-University of Chicago; and Dr.Robin Powell (,57), Associate Dean, NorthwesternMedical School.New president, Dr. Fitch, who has been on the Uni­versity'S faculty since 1957, earned his M.D. and Ph.D.degrees in pathology at Chicago. He is Chairman of theCommittee on Immunology and he is widely known forhis immunologic research and considered an expert in theoften tricky development of hybridomas.Dr. Fitch received a Guggenheim Foundation fellow­ship in 1974 to conduct experimental research in cellularimmunology and his current interests involve selective control of cellular immune responses, both in vivo and invitro. He and Dr. Frank Stuart, Professor in the Depart­ment of Surgery, have successfully collaborated on re­search to reduce and in some cases eliminate the problemof rejection following kidney transplants in small animals.He belongs to many medical societies and organiza­tions including the American Association of Im­munologists, the American Association of Pathologistsand Bacteriologists, and the American Society for Ex­perimental Pathology. Dr. Fitch is also on the editorialboard of the American Journal of Pathology, and as­sociate editor of the Journal of Immunology. In recogni­tion of this "long-standing commitment, involvementand dedication to educational matters," Dr. Fitch wasappointed Associate Dean for Medical and GraduateEducation of the University's Division of Biological Sci­ences and the Pritzker School of Medicine in 1976, aposition that he still holds.Dr. Fitch joined the University of Chicago faculty in1957 as an Instructor in Pathology. He was named As­sistant Professor in 1960, Associate Professor in 1963, andProfessor in the Department of Pathology in 1967.His academic appointments include two years spent inSwitzerland as a visiting professor, first at the Institute ofBiochemistry of the University of Lausanne (1965-1966)and then at the Swiss Institute for Experimental CancerResearch while a Guggenheim Fellow (1974-1975).Dr. Fitch is married to Shirley Dobbins Fitch and theyhave two children, Mary Margaret, age 23, and MarkHoward Wesley, age 18.23rOday, everyone, who is anyone, goes to China. Somepeople have even been there several times, andmost of us have been bored to death by the starry-eyedassertions of all the wonderful things that the Chinesehave accomplished in the last few years. I suppose this isas it should be. The Chinese have had more experienceduring the past 3,000 years than we have.They invented paper, movable type, and gunpowder.They developed a great system of paramedics (thebarefoot doctors), acupuncture, moxybustion, and acomplex, difficult language. They have been im­poverished and have survived and they have done somethings with limited resources that we would not evenconsider attempting here with all our resources.24 An example: When I was in Shanghai I saw a youngman who a year earlier had been diagnosed as having asarcoma of the humerus. The surgeon had removed theentire humerus, and sutured the lower arm to the shoul­der. The nerve and blood supplies had been preserved intoto and he had a fairly functional arm with a normalhand. It was obviously a "little" shortened but howmuch better than an amputated limb. That was 1973, bynow they have probably worked out a plastic or steelimplant to preserve the length and serviceability of theentire arm.Most of us may have forgotten, but the University ofChicago has a Chinese heritage. Original faculty mem­bers Franklin McLean and Paul Hodges and others cameto Chicago from P.U.M.e.-Peking University MedicalCenter. So, it was natural that I visit P.U.M.e. when Iwas in Peking six years ago.There was not much in 1973 to hold our attention. Thehospital beds were still full and the ambulatory patientsscattered about the grounds, but the doctors we met werequiet, retiring, and not particularly friendly. Most of thefaculty from the early 20s was gone. There were very fewmedical students-education having been severely cur­tailed by the Cultural Revolution of 1966. I did see onefamiliar face, however.Does anyone remember Bobby Winter? He taughtFrench at the U. of C. in the early 20s. I guess he was agood teacher, he certainly liked teaching. At least, he feltcompelled to help us pass the French reading aptitudetest that was required for admission to medical school. .In 1923, Bobby Winter went to China and never cameback.How do I know? Because fifty years later, fifty yearsafter he taught me French, Kenny Gilchrist ('31) and Ihad dinner with him in Peking.We can read all about the wonderful things that havehappened and are happening in China in countless recentbooks, but who is going to tell us about Bobby Winter?At Home in PekingDr. Edwin J. DeCosta ('29)Only Gilchrist or I. So, I offer a word or two about ourold teacher.Bobby Winter was born in about 1886, so in 1923 hewould have been 37 years old. Young enough to impressan eighteen-year-old and old enough, I hope, to knowwhat he was doing.He was tall, good looking, and an aesthete with inter­ests in music, art, the theater, and the Chinese. BetweenFrench recitations he would study a deck of cardsmarked with Chinese characters. Our curiosity was natu­rally whetted. We learned that he had been invited to teachat the University of Nanking and was getting ready toleave Chicago at the end of the quarter.1 often wondered in subsequent years what happenedto Bobby Winter. 1 was curious to know why an Ameri­can went to China with all of its unrest and problems andhow he made out. Since the Boxer Rebellion in 1900,China had been in a state of chaos with bloodshed sur­facing here and there. But, I had other things to thinkabout and Bobby Winter was eventually forgotten.Fifty years later 1 was in China having dinner with him.How did we happen to meet? By accident, of course.China is a huge place with a population of close to abillion people. 1 did not know if he was alive, whether hewas in China or not, and if so, where. Even if 1 had beeninterested in searching for him it would have been im­possible. 1 would not have known where to start.A ccidental happenings are fascinating and sometimes"'spooky. In 19731 was in China as a part of Friend­ship Delegation to the People's Republic. For threeweeks we had traveled with guides to the various largecities. In Peking, 1 ran out of razor blades. While tryingunsuccessfully to communicate with the shopkeeper inthe hotel, a Caucasian woman came to my aid. By way ofpleasantry 1 asked what she was doing in Peking, and she in turn asked me the same question. When 1 said I wasfrom Chicago, she rejoined with, "Then you must knowProfessor Winter." Nonchalantly I said, "I do or did, buthow do you know him?" "He's my next door neighbor,"she replied.I have encountered "small world" coincidences be­fore, but never on the other .side of the globe andtraversing fifty years. To make a much longer story short,he joined us for dinner that same night.There were twelve in our party. Twelve, an appropri­ate number, sat at the master's feet. For hours we pliedhim with questions, which he answered promptly andhonestly. When the" seminar" ended we had all experi­enced one of those rare, unexpected occasions in lifewhich seems to happen always and only to someone else.Robert Winter was robust, clear of eye and mind, andat 87 was still teaching at the University of Peking, andhad never married. He could write a book about his ex­periences, but probably never will. When you live inChina for fifty years, in contact with the convulsivebirth of a new society, you are in a position to be authorita­tive. Much more so than those visitors who pass throughand then pontificate about this unfamiliar giant. For us,it was an experience of a lifetime and we listened, rapt.1\1' e also met another interesting American inW China-Dr. George Hatem-who had not re­turned to the United States since 1929. (Winter had re­turned once in the 40s). Dr. Hatem (ma Hai-teh) receivedhis pre-med education at Chapel Hill, North Carolina, hismedical degree at the American University in Beirut, andarrived in China in 1933. He has been the guiding hand inthe communal health programs which more than a decadeago eliminated VD, malaria and the plague from themainland.The afternoon I spent with Dr. Hatem is never to beforgotten. Being interested myself in the problem of VDcontrol, 1 asked Dr. Hatem what he would do if 1 were ina position to bring him to the U.S. and to put whateverfacilities he wanted at his disposal. He replied simply, "Icould do nothing. Veneral disease is a social problem.Social problems are solved by the will of the people andthe United States is not socially conscious enough towant to do anything about it." I thought that over. It goesa long way toward explaining many problems that con­front us today in America.1 have reminisced about events of six years ago. Now,1 should bring you up to date to the best of my knowl­edge. 1 have not heard from Winter for several years, butas of 1974 he was alive, well and, 1 hope, happy. I canonly wish him the good fortune of having been around towitness the rapport we have recently established withChina.As for Dr. Hatem, he became seriously ill and returnedto the U.S. for treatment. I did not hear anything for along time, but just recently I received a New Year's cardfrom him. There was no mention of his health, but hishandwriting was strong and the letter was postmarkedPeking. So, he is back home.25Four medical alumni and one divisional alumna of theUniversity of Chicago were honored May 19 at the Uni­versity's annual reunion luncheon and awards assembly.Three alumni received Professional AchievementAwards in recognition of attainments in their vocationalfield bringing "distinction to themselves, credit to theUniversity, and real benefit to their fellow citizens."Two alumni were honored with Public Service Cita­tions in recognition of their having "fulfilled the obliga­tions of their education through creative citizenship andexemplary leadership in community service."From the University with Honors .... . . for Public ServiceDr. Egbert H. Fell ('31), Emeritus Clinical Professor of Surgery,Rush Medical College, is an internationally known pioneer inthe techniques of cardiac surgery. He received theDistinguished Service Award of the University of ChicagoMedical Alumni Association in 1963; with Dr. Benjamin Gazul,he developed the cardiology unit at Cook County Hospital intoone of the finest in the country. Noted for his work withchildren's heart disease, his publications record includes morethan 500 articles in learned journals and medical textbooks.While in private practice in Chicago he freely devoted much ofhis time to the sick and indigent at Cook County andPresbyterian Hospitals and the Central Free Dispensary. At theheight of his professional career in 1965, Dr. Fell elected tobecome a medical missionary. He and his wife were assigned tothe American Mission Hospitals of the Middle East (Kuwait andMeshed, Iran) where they worked for 2Vz years. For the nexttwo years as Chief of Surgery at the Haile Selassie UniversityPublic Health College, Gondar, Ethiopia, he helped train healthworkers for the World Health Organization in an extraordinarilydifficult medical environment. He has continued his dedicationto service at a clinic for the disadvantaged on the Kona Coast inHawaii. Through his concern for the welfare of the sick amongthe urban poor, in Third World countries, and among thedisadvantaged in Hawaii, Egbert H. Fell continues to fulfill theobligations of his education in creative citizenship.26 Dr. Egbert H. Fell ('31) and Mrs. FellOr. William Moses Jones ('32) and Mrs. Jones• • • for Professional AchievementHarriet George Barclay (Ph.D. '27), is Emeritus Professor ofBotany of the University of Tulsa. Retirement only expandedher classroom: she is frequently a visiting professor atuniversities throughout North and South America. Herexplorations of high-mountain flora throughout the world haveresulted in the discovery and cataloging of many new species ofalpine flora. Prof. Barclay made one of the most significant plantcollections ever attained from the Andean paramos and pun as .This collection at the National Herbarium is an unparalleled toolfor the study of plant communities, and is an importantcontribution to plant taxonomy. Some of her discoveries bearher name; for example, three compositae from Colombia andEcuador: Espletia barclayana, Diplostephium barclayanum,and Senecio harrietae. Her ecological knowledge is shared withothers not only in classrooms, but also in lecture halls and onfield tours in North and South America, Europe, and Africa. Anadditional talent as an artist and wildlife photographer enhancesher communication of plant geography. The Rocky MountainBiological Station in Colorado has received her support and aidin programming, and Red Bud Valley near Tulsa is preservedfor study of the ecology of a classic limestone area because ofher interest. Traveler, collector, ecologist, and artist, HarrietGeorge Barclay has pushed the frontiers of plant geography intonew areas. Dr. William Moses Jones ('32), is a creative force in theencouragement of young doctors and black youth. Now inprivate practice as an ophthalmologist in Chicago, he spentmany years as a member of the teaching staff at the MedicalSchool and Clinics of the University of Chicago and in theStudent Health Service. He is on the staffs of Woodlawn,Jackson Park, and Provident Hospitals in Chicago and SturgisMemorial Hospital in Michigan, where he and his wife donatefacilities and operate an American Camping Associate nonprofitcamp, which has served the Chicago Metropolitan YMCA,Cosmopolitan Nursery, and Girl Scouts and children of theDeaf School, Constantine, Michigan, as well as other campers.He is a Fellow of the American College of Surgeons and of theAmerican Academy of Ophthalmology, and in 1973 was namedhonorary president for life of the Roman Barnes Society ofOphthalmology and Otolaryngology because of the stimulus heprovides to young ophthalmologists. As a consultant to theChicago Board of Education, he generously provides counselfor follow-up care for school-aged children. For thirty years hehelped to develop and conduct the John A. Andrew ClinicalSociety workshops at Tuskegee Institute that increasedopportunity for the professional interracial development ofphysicians and surgeons and for service to the needy sick.William Moses Jones has helped others develop theirophthalmological skills and opened new horizons to youngdoctors.Harriet George Barclay (PhD. '27)27Right, Dr. Clinton L. Compere (,32) and author James T. Farrell (deceased)Dr. Hugh A. Edmondson ('31), retired as chairman of theUniversity of Southern California (USC) School of Medicine'sPathology Department in 1972, after almost 40 years on itsfaculty. Five years later USC awarded him an honorary LL. D.When he became chairman, the department had 3 members; itnow has more than 60 full-time faculty. He conceived anorganization plan with interwoven clinical specialities and basicdisciplines and established an innovative graduate program inexperimental pathology leading to the Ph.D. degree. Dr.Edmondson is the author of two fascicles in the Atlas a/TumorPathology; he has made major contributions to the knowledgeof liver disease and has recorded his research in extensivepublications. For instance, his early recognition of the linkbetween benign liver tumors and oral contraceptives hasopened up new avenues for the investigation of hormone effectson liver-cell histology. He introduced the term "alcoholic liverdisease" and made original contributions to the pathologicphysiology of acute pancreatitis. He is a Trustee of theEisenhower Medical Center, Palm Desert, and President of theBoard of Directors of the Estelle Doheny Eye Foundation, LosAngeles. A former member of the Council of the InternationalAcademy of Pathology, he also served as national committeechairman of the American Medical Association's Section onPathology and Physiology and was a leader of the Los AngelesCounty and the California Medical Associations' Sections onPathology. Hugh A. Edmondson is a general pathologist andeducator whose research has established new knowledge ofdiseases of the liver.28 Dr. Clinton L. Compere ('32), is Edwin W. Ryerson Professorand Chairman of the Department of Orthopedic Surgery atNorthwestern University. Following six years of active duty inthe Army Medical Corps, he returned to Chicago with anappointment to the Northwestern Faculty in 1946, and to theSenior Attending Staff at Chicago Wesley Memorial Hospital.He has served as Chief of Staff there, as Director of the Boneand Joint Pathology Laboratory at Northwestern, and as aconsultant at Henrotin Hospital (1955-1977) and to the VeteransAdministration. In 1972 he became Director of theRehabilitation Engineering Program at McGaw Medical Center.It is primarily through his efforts that Northwestern is one of thethree major centers in the United States for research andtraining in prosthetics and orthotics. He has participatedactively in the origin and growth of the Rehabilitation Instituteof Chicago, and continues to serve as Vice-Chairman of theBoard of Directors. Dr. Compere was one of the first physiciansto initiate clinical and laboratory research for joint replacement.He developed cooperative efforts between engineeringscientists and orthopedic surgeons for better patientrehabilitation. He has been Secretary and President of theAmerican Academy of Orthopedic Surgeons (1973) and anofficer and organizer of other professional groups. Clinton L.Compere has distinguished himself through his skillfultreatment of patients, effective teaching, service to nationalorganizations, consultantships to federal agencies, andcontributions to prosthetics research and development.Dr. Hugh A. Edmondson ('31) and Mrs. EdmondsonAn Interview with Dr. Whitney AddingtonDr. Whitney Addington is Professor in the Department ofMedicine and head of the Section of PulmonaryMedicine. Dr. Addington, who was chairman of theDivision of Pulmonary Medicine at Cook CountyHospital in Chicago from 1973 to 1979, w�s appointedchairman of the University's section July 1.From 1969 to 1977, Dr. Addington was on thefaculty ofNorthwestern University Medical School and anassociate professor of medicine at the University ofIllinois Abraham Lincoln School of Medicine from 1977to 1979.Dr. Addington heads an enlarged, mostly new facultyin pulmonary medicine, the result of intensive effortsover the past several years to rebuild the section. Abright, modern, newly renovated clinic area andincreased bed space promise an emphasis on patientcare. At the same time, more faculty and a revisedtraining program have made more and better teachingavailable to students and housestaff, and the youngerfaculty involvement in investigations should spurresearch activities.Dr. Addington was interviewed by the editor ofMedicine on the Midway.Focus on Pulmonary MedicineMOM: Dr. Addington, how many faculty now make upthe Section of Pulmonary Medicine?ADDINGTON: As of July 1, we have five full-time facultymembers and one part-time clinical professor. Full-timeare: Dr. T. William Lester ('41), who until recently wasthe only full-time member of the section and who hasbeen on the University's medicine faculty a total oftwenty-two years; and three newly recruited faculty inaddition to myself.Dr. Arthur Banner came to us from Cook County Hos­pital and the University of Illinois Abraham LincolnSchool of Medicine where he was assistant professor ofmedicine.The other two, Dr. Alan Leff and Dr. Eugene Geppert,have both recently completed research fellowships at theCardiovascular Research Institute in San Francisco. Dr.Geppert is a former housestaff member of our MedicalCenter. In addition, Dr. William Barclay, who headed the Uni­versity's Pulmonary Medicine section for many years andleft to accept a post as vice-president of the AmericanMedical Assocation (AMA) and editor of the Journal ofthe AMA, has returned as a part-time clinical professor.Thus, we have gone from a very small pulmonary sec­tion to one of the larger ones in the country in terms offull-time commitment.MOM: What are your immediate goals now that you havea new, enlarged staff?ADDINGTON: My highest priority is to reestablish excel­lence in our clinical activity. We have a pulmonarymedicine outpatient clinic everyday, Monday throughFriday in a very attractive, pleasant clinic located in anewly renovated area in the larger general medicineclinic. We now have more clinic space, more examiningrooms and we hope to offer not only an excellent, but an29efficient consultative service for our own patients andreferrals. I hope to early establish a good referral net­work.MOM: What plans do you have concermng inpatientcare?ADDINGTON: We have increased the number of inpa­tient beds (located on North 2) to ten and are adding aclinical nurse-specialist with expertise in pulmonary care.We will also perform fiberoptic bronchoscopies on North2. Our pulmonary function laboratory will be moved tothe new 3,500-square-foot area set aside for us in theGilman-Smith Hospital benefitting both out- and in­patients. It will be totally redesigned to include the latestand most sophisticated laboratory equipment. Here, thelab will be accessible to all technicians, students, house­staff, and faculty.One of the most important aspects of our inpatient carewill be the attending service. I am personally taking themonth of July as attending physician because I want thestaff to know what I mean by attending: to know everypatient on the service, make rounds every day, and totake an active part in caring for the patient. I feel it is veryimportant for referring physicians to know that whenthey send us patients from some distance and at someinconvenience, our full-time faculty are seeing them.MOM: The renovated area on the sixth floor of Gilman­Smith Hospital will house your offices, a tissue culturelaboratory, and a conference room in addition to the pul­monary function laboratory. There are plans to use thatconference room for teaching, is that correct?ADDINGTON: Yes. There will be study carrels andbooks and journals for housestaff and medical studentuse. Undergraduate medical education is a particularinterest of Dr. Banner's. He has submitted a grant re­quest to implement a reorganized pulmonary medicineeducation program-one that will encompass all fouryears of medical school. From the start, however, ourmedical students and housestaff have been participatingin a substantially revamped training program.MOM: Can you briefly describe some of the changes inyour medical training programs?ADDINGTON: We will have a very close relationshipwith Michael Reese Medical Center in our training pro­gram. In fact, they have been providing much of themedical student teaching. Now, with extra faculty, wecan offer a strong combined program, rotating our clinicaland research conferences between the University andMichael Reese.We began a combined fellowship program in July andhope to have it in full swing by next year. The MichaelReese full-time faculty, headed by Dr. Peter Szidon, con­sidered one of the authorities on the pulmonary circula­tion in this country, is superb. Other full-timefaculty-Dr. Evan McLeon and Dr. Raj Gupta-are bothvery well trained physicians and excellent clinicians. In30 addition, two outstanding voluntary physicians, Dr. Irv­ing Mack and Dr. Milton Mosko, participate in all ac­tivities.Here at the University, we will be offering many moreand a greater variety of teaching programs. Our studentsand house staff will be working with experienced clinicalfaculty like Dr. Barclay, Dr. Lester, and myself and withbright young faculty like Dr. Banner, Dr. Leff, and Dr.Geppert who are doing exciting basic research. Despiteour particular, individual interests, each of us valuesclinical care, teaching, and research. We intend to supportand collaborate on all three of these aspects of academicmedicine in our section.MOM: What are the research interests of the faculty?ADDINGTON: Because the interests and expertise of ourfaculty are varied, we will be involved in both clinical andbasic research.Dr. Banner and I have a longstanding interest in bron­chodilator drugs and the treatment of asthma. We havedeveloped a number of protocols which will be used toconduct clinical investigations of asthma patients who arereceiving bronchodilators.Dr. Geppert has been working at the CardiovascularResearch Institute on a model for the culture of lungcells. This is a brand new world in pulmonary medicinebasic research. The implications for the study of diseasesand the affects of drugs on abnormal cells, should thisresearch succeed, are limitless. A special laboratory forthis tissue culture research is planned for the new Pulmo­nary Medicine area in Gilman-Smith.Dr. Leff, also at the Cardiovascular Research Institute,helped to develop the latest experimental animal modelfor asthma. He will continue this work here, focusing onthe basic mechanisms of asthma and its modificationusing a variety of drugs. Laboratory space has been setaside for him in the A. J. Carlson Animal Research Facil­ity at the Medical Center.Although Dr. Leff and Dr. Geppert will initially be de­voting the majority of their time to their research proj­ects, they will also be seeing patients in the clinic.MOM: In order to get your inpatient service, clinic,training program, and research underway so quickly, youmust have done a lot of advanced planning. How longhave you been involved in planning the activities of thesection?ADDINGTON: We have been actively preparing for sixmonths so that we would be ready to go on July 1.MOM: You have been chairman of this essentially newsection for only a short while, but how have you found it?ADDINGTON: Very gratifying. We have had excellentsupport from the Medical Center to meet our teaching,clinical, and research aims and good cooperation fromother departments. I remain very excited about the pos­sibilities of offering in our section the very best there is inpulmonary medicine.A Close Encounter with FameA MemoirDr. Henry R. JacobsIn dangerous confrontations the term "near miss" oftenconnotes a happy outcome. The term serves less well ifthe outcome is indifferent or less than happy. Bettersuited then is the felicitous one, "close encounter," em­ployed so well by Professor Hynek in his famous dis­quisitions on unidentified flying objects.In this view the title of this memoir implies that theoutcome of the episode to be related was not entirelyhappy. It occurred at Billings Hospital during the depres­sion years, when everything was difficult. There was dis­sension among members of the medical staff, particularlybetween surgery and medicine. The chief of surgery be­lieved that the head of medicine should be replaced. Areplacement from Mayo departed after a brief stay; it wasthought that he could not endure the constraints put uponhim. The dean of biological sciences then suggested thatDr. George Dick be recruited. After several sessions histhought prevailed.I had been Dr. Dick's intern and resident at Presbyter­ian Hospital and when he proposed that I accompany himI gladly accepted. (That was early in 1934 when Jay Ber­wanger was "big man on campus," owing to his prowessin football.) It quickly became evident that Dr. Dick and Iwere vulgar intruders into an elitist group. * Some of thedifficulty was that the University sought more incomefrom the medical division but the elitists seemed incap­able or unwilling to produce it. Dr. Dick was a successfulpractitioner of medicine and famous for research in scar­let fever. In short, here was a war horse stabled withwell-bred ponies. I do not wish, by insinuation or other­wise, to suggest there was ever anything reminiscent ofthe OK Corral. Everything was pro forma, but incomefrom the medical division did rise.Circumstances had imposed a strain on everyone. Thedepression had frightened the faculty. There were salarycuts, no promotions, and there was always that deadlyincubus, publish or perish, haunting waking and sleepinghours. And worst of all, there was no money to supportresearch that might produce results fit to publish.Now here was a fine situation. If ever there was occa­sion for prayer or for looking to the hills from whencecometh help, this was one. But folk wisdom suggestedthat desperation is not curable by consolation, that itsoaks morbidly into the fiber of the being to displacespontaneity and ebullience, and that it ages you and gives you a leg-up toward the earned degree of VMDS (veteranof many desperate situations).Anne Sullivan was secretary to Dr. Dick and factotumfor the Department of Medicine. She was everyone'sfriend. For her there was no evil in the world. She under­stood the plight of the junior members. I had a hundredreasons to appreciate her. I recall her reconnoitering thebone-bare finances of the department for five or ten dol­lars to buy a few rabbits for me. Where she found moneyI shall never know. I suspect she used magic. In thosedays my research allotment was fifty dollars a year;largess was not the word. But angel was the word forAnne Sullivan.Somewhere I had learned that lubrication of sleevebearings consists essentially of keeping the axle separatedfrom the bearing by a thin layer of lubricant, and that thebest lubricant is a long molecule with differing ends. Oneof the ends should have an oxidized group that has astrong affinity for the metals of the bearing while theother end has none. Presumably the lubricant stands up­right on the metal surfaces so that motion in the bearingtakes place between the free ends of the lubricant.There are a great many oxidized molecules that haveno long chains attached; they are not good lubricants.Alloxan is one of these. It does not occur free in nature.By substituting two hydrogen atoms for one oxygen itbecomes barbituric acid, a well-known pharmaceutical.The surmise that it might affect carbohydrate metabolismhad no precedent; that thought, like Proteus rising fromthe sea, arose out of nowhere.My first experiment with alloxan was by far the mostexciting. I made an aqueous solution of alloxan and gaveit to a rabbit by vein. The dosage was 75 mg of alloxan perkilogram of rabbit; it was given at eight in the morning.There was no immediate effect. I left for the clinic whereI forgot about the rabbit for two hours. At ten o'clock theanimal looked entirely well. I drew blood for the glucosecontent and returned to the clinic. An insulin effectshould have appeared in the elapsed two hours. Sincenone had I suspected that the whole idea was nonsense.At eleven-thirty a slack moment in the clinic allowedme to return for a last look. You may imagine my as­tonishment when I saw the rabbit on the floor in con­vulsions. It was rolling over and over incoordinately intypical insulin (hypoglycemic) convulsions. I was seeingwhat I very much wanted to see.Then came a moment of stern self-appraisal. I certainlywanted to see what I was seeing, but could I be hal­lucinating? Surely what I saw was indeed there, I be­lieved. But patients who hallucinate are equally certain ofreality. I knelt beside the rabbit and held it in my handswhile it convulsed actively. Again I felt certain that Iknew what was going on, but I also knew that certainty ismost characteristic of hallucination. If these were indeedhypoglycemic convulsions they should stop immediatelyafter glucose intravenously.Sweating and tremulous, I gave glucose intravenously.While trying to insert the needle I repeatedly puncturedmy thumb, owing to my tremor. Within one minute theconvulsions stopped, and seconds later the animal satupright in a normal posture and sniffed at a leaf of lettuce.Again I reflected on the certainty that hallucinators have.I was well acquainted with hallucination. While servingas a summer intern in a state institution I had madefriends with the Queen of Rumania (she thought) andhelped her review her household troops (imaginary) onthe hospital lawn many times. Each time she thanked mein royal fashion and dismissed me. I also helped anotherlady pick worms, which kept appearing and spinning silkstreamers, from her face and neck; while helping her withthe worms (which were not there) we engaged in quitenormal conversations about her distant past. Worm­disposal had been her full-time occupation for thirty-fiveyears. I marvelled at the good rapport one can establishwith such patients. I remembered having to return to theclinic. Still clammy and tremulous, I ran upstairs hopingto regain calm, but on entering the clinic the nurse said,"Are you all right? You look so pale." I said I had justrun upstairs to get back to work.The original experiment was easily repeated. In shortorder I had material enough for publication. The paperwas returned by the editors with the admonition that Ihad better repeat the work-and more carefully. Duti­fully, I did the experiments three more times with thesame result. The editors accepted it for publication; itappeared in 1937. t71In my opinion the paper was gravely flawed because Idid not supply descriptions of the microscopic appear­ance of the pancreas. I suspected that the surviving ani­mals were ill with a disorder of carbohydrate metabolism32 because they grew thinner, had high blood sugar levelsand sugar in the urine. But I had been totally thwarted inmy efforts to get preparations for microscopic examina­tion.While I was a research fellow at Rush-Presbyterian Ihad become expert in preparing specimens of the pan­creas for microscopic examination, employing Bensley'Sstain for the beta-cells of the islets. Under Dr.Woodyatt's influence I was involved in studies of car­bohydrate metabolism and I had published some papers.It was to be my metier.I could not get started at Billings. First of all, the medi­cal department had no facilities or personnel for histo­logical studies. Dr. Dick suggested that I ask the pathol­ogy department to cut sections that I would stain. Theresponse (from EH) was, "we do not do everybody'sresearch for them" and they declined flatly.Next Dr. Dick suggested that I discuss the matter withDr. Carlson of physiology. That turned out badly too. Dr.Carlson said, "Vot do you vant?" I described the alloxaneffect and said that I needed help with microscopicexaminations of the pancreas. He said, "Vot iss el­locksen ennyvay?" and turned away impatiently.There was a comic episode. Since I was completelyblocked, Dr. Dick said he would see what he could do.Apparently he foraged all the coasts and purlieus of Bil­lings Hospital; he returned with a piece of an ancientsliding microtome, sans knife, sans carriage, sans every­thing except the lower slide, which by itself was worth­less. He offered me the piece and suggested that I mightwork in one of the bays of a corridor nearby, perhapsusing the window sill for a table. Surely he was jesting.Anne Sullivan wouldn't say.I resigned from Billings in the fall of 1938. Early in 1939while working in Uganda on yellow fever (RockefellerFoundation) I began to receive impatient letters, com­plaining that my work was not reproducible. This was in­credible. I responded patiently that the alloxan had to bepure and that it should not be exposed to alkalinization,which would destroy it instantly. I received no repliesand I still wonder what their problem had been, since thealloxan effect has been verified a thousand times.If an occasional ephebus should in his wisdom opinethat after I discovered alloxan's effect on blood sugar Ihad not the wit to proceed, tell him he wrongs my mem­ory. I had the wit but not the opportunity. It was a closeencounter with fame.*Palmer, Walter T.: Franklin Chambers McLean and thefounding of the University of Chicago School of Medicine. Per­spectives in Biology and Medicine 22(no. 2, pt. 2):S2-S32,Winter 1979. :Jt Hypoglycemic action of alloxan. Proceedings of the Societyfor Experimental Biology and Medicine 37:407-409, 1937.The ti mes changeAnd we change with them.-From Owen's EpigrammataName Graduation YearHome Address TelephoneCity, State, ZipBusiness Address TelephoneCity, State, ZipTitleNew address?New position?New medical practice?military assignment?civic or professional honor?book?Please tear out; fold, staple, or tape; and drop in the mailbox. Thanks!Medical Alumni Association1025 East 57th StreetChicago, Illinois 60637 ;--- - ----I1 11 Place 11 11 Stamp :1 1Here 11________ J---------------------------------------------------------Fold this flap in firstMedical Student in There PitchingWhen Robert Stratta applied tomedical school several years ago,not all the deans who interviewedhim liked his pitch.Stratta was a standout pitcher atthe University of Notre Dame whichhe attended on a baseball schol­arship. Had he not desired a careeras a doctor, he said he had a shot atthe major leagues.Stratta, 24, now is a third yearmedical student at the University ofChicago Medical School who hasfound he could maintain a summersemipro playing schedule and hos­pital rounds, too."I was really struck when I firstwent on interviews for medicalschools," he said. "They were reallygrilling me on the baseball aspects ofmy life. I could see their point, thatmedical school is a full commitmentand you're taking care of people'slives."Some interviewers thought mybaseball involvement up to the endof undergraduate school was fine,but now I should give it up. At theUniversity of Chicago, I had aninterview with Dean (Joseph) Ceit­haml, and for 40 of the 45 minutes wetalked about baseball.""Our attitude is that studentsought to have extracurricular ac­tivities or expertise in other ac­tivities besides their studies," Ceit­haml said. "I would have been just asencouraging if he wanted to play theoboe, flute or do long-distance run­ning. "Stratta, who has been a baseballplayer since the age of 8, and whowas a star player at Rich CentralHigh School [in Chicago], said, "Inever would have gotten into medi­cal school if not for baseball. Iwouldn't have had the money to goto a good academic (undergraduate)school."Starting this month, Stratta willplay three or four games a week as Lynn SweetRobert Stratta slugs one during a semipro game in the Chicago suburbs.he starts his fourth season as apitcher, outfielder, and designatedhitter with the Ahepa, a semiproteam whose home field is 43 milesaway from Hyde Park at Lewis Col­lege in Lockport.Stratta will try to play in as manyof the season's 73 games as he can;in July, he begins a surgical rotationat the University of Chicago Hospi­tals and Clinics, and the longer hoursmay mean he has to cut some games.But the aspiring surgeon recom­mends exercise for everybody, evenif it is not semipro baseball, saying:"I always felt I was a lot morealert when I was in good physicalcondition. It gets harder to do as youget higher in medical education, andplaying ball does take a lot of time."The most difficult part of Stratta'slong summer days is not the poten­tial physical exhaustion but gettingmentally tired."The mental approach to pitchingis important," he said, "and I'll beon the mound thinking about some- thing that happened in the hospitalfor a few innings . . . and the nextmorning after a good game, you haveto put it out of your mind."For older guys, semipro ball is ademanding thing. There are a lot ofgames, and there are always timeswhen you have to take off workearly."... There are times when Iknow I'm pitching and I may ask theintern or resident if I can get off alittle early, but I can't take advan­tage of the situation."Although not yet a surgeon,Stratta sees some parallels betweenpitching and surgery:"Being a pitcher in a big game islike being a surgeon in a big opera­tion. You're in control of what hap­pens and how other people do de­pends on how you perform."Lynn Sweet is a staff reporter withthe Chicago Sun-Times. This articleis reprinted with permission from theauthor and the Sun-Times where itappeared May 28, 1979.35Residency Assignments- 1979Of the 99 students in the senior medical class this year, 90participated in the 1979 National Residency MatchingProgram (NRMP). Of these, 42 were matched to the hos­pital of their first choice and 29 were placed at hospitalsof their second or third choice.Of the 9 students who did not participate in NRMP, 2graduated in December 1978 and began residencies inJanuary 1979. Two students were attending medicalschool under the Armed Forces Scholarship Program andwere obliged to take military residencies, one in theArmy and one in the Navy. Two other students partici­pated in a separate Ophthalmology Matching Programwhich took place in the fall of 1978, and another sought a'surgical residency outside the NRMP.Two students decided to postpone their residency forone year. One is an M.D'/Ph.D. student who decided topursue a postdoctoral fellowship in Biology at the Uni­versity. The other will work as an associate editor of theJournal of the American Medical Association in Chicago.Of the 96 students beginning their residencies in 1979-1980, the largest number, 39, will be in Internal Medicine.Another 23 will be in Surgery and 2 more will pursueOrthopedic Surgery. Ten students will be in Pediatricsand 4 in Psychiatry.The complete distribution by clinical discipline of thisyear's residencies is given in the Table."Flexible" residencies are similar to rotating intern­ships of the past. The other two types of residencies are"categorical"-analogous to the former straightinternships-and "diversified"-analogous to theformer mixed internships, with the major componentbeing a specific clinical discipline.Of the 90 students who received their appointmentsthrough NRMP, 76 students (84 percent) received ap- pointments in residency programs that filled all of theirallocated positions in the NRMP. Similarly, of the 67different hospital units where Chicago students begantheir residencies in July, 56 residency programs (84 per­cent) filled all of their allocated positions in the NRMP."A look at the residency assignments of 1979 showsthat members of the senior class are serving at excellentteaching hospitals throughout the country," says DeanJoseph Ceithaml."The continued success of our students year after yearin the NRMP can, in my opinion, be directly related tothe excellent cooperative efforts of our students and fac­ulty."The members of the Committee on Residency Place­ment of Senior Medical Students and its chairman, Dr.Robert Replogle, deserve the gratitude and commenda­tion of our students and our faculty for the time and en­ergy spent on the behalf of the senior medical students."TABLEDistribution of Residency Assignmentsby Clinical DisciplineAnesthesiologyFamily PracticeFlexibleInternal MedicineObstetrics & GynecologyOphthalmologyPathologyPediatricsPsychiatryRadiologySurgeryOrthopedic SurgeryTotal 14639132104223..197HospitalsBarnes Hosp. Group, SI. Louis (4)Baylor Coli. Affil. Hosp., HoustonBoston Univ. Affil. Hosp.Bronx Municipal Hosp. Or.Chestnut Hill-Jefferson, Phila.Children's Memorial Hosp., Chicago (2)Columbia, S.c. Richland Ctv, Hosp.Cook County Hosp., ChicagoDuke Univ. Med. Or.George Washington Univ. Hosp., D.C.Grady Mem. Hosp., Ga.Hosp. Univ. Health Ctr., Pitts. (2)L.A. Ctv. Harbor-UCLAMassachusetts Gen. Hosp. (2)Medical Coil. of PennsylvaniaMichael Reese Hosp., Chicago (8)N.Y. Univ. Med. Or. (4) North Carolina Mem. Hosp.Northwestern Univ. Med. Or.Overlook Hosp., N.J.Pennsylvania Hosp.Presbyterian Hosp., N.Y.Presbyl.-St. Lukes Hosp., Chicago (2)Rockford Med. Educ. Fdn., III.Roosevelt Hosp., N.Y.C.St. Francis Hosp., PeoriaSI. Louis Children's Hosp. (2)SI. Mary's Hosp., MadisonStanford Univ. Hosp. (3)Strong Mem. Hosp., N.Y.Temple Univ. Hosps.U. of Alabama Med. Or. (2)U. of Calif. Affil. Hosp., Irvine (3)U. of Calif. Hosp., L.A. (3) U. of Calif. Affil. Hosp., S. DiegoU. of Chicago Hosps. (9)U. of Colorado Affil. Hosp. (5)U. of Illinois Affil. Hosp. (2)U. of Iowa Hosp.U. of Kansas Med. Or.U. of Maryland Hosp.U. of Minnesota Hosp.U. of Missouri Med. Or.U. of Pennsylvania Hosp. (3)U. of Washington Affil. Hosp. (2)Vanderbilt Univ. Affil. Hosps.Virginia Mason Hosp., Wash.Wayne State Univ. Affil.Yale-New Haven Med. Or.36Student HospitalJ. Davis AllanJudith BanksStephen BartlettSteven BerkAnne H. BrennerDaniel BrookeCynthia BrownsonJames BuddSteven BurresJoseph Carter Presbyterian Hosp., N.Y.Children's Mem. Hosp., ChicagoU. of Pennsylvania Hosp.U. of Chicago Hosps.U. of Colorado Affil. Hosp.Navy Med. Ctr., Oakland, Calif.U. of Chicago Hosps.Strong Memorial Hosp., N.Y.Wayne State Univ. Affil.U. of Chicago Hosps.David ChalifBruce ChienCurt ChristiansenAnne ConnorWilliam CookeDeCarr CovingtonJohn ElkinsWilliam J. ElliottVictor ElnerJean Emond N.Y. Univ. Med. Ctr.U. of Iowa Hosps., Iowa CityHosps. Univ. Health Ctr.. Pitts.N.Y. Univ. Med. Ctr.St. Mary's Hosp., Madison, Wis.Stanford Univ. Hosp.U. of Calif. Affil., IrvineBarnes Hosp. Group, St. LouisU. of Chicago Hosps.Cook County Hosp., ChicagoRick EspositoSheila FallonIrwin FeintzeigMichael FelongRobert FineJames FosnaughDebbie Frei-LahrWilliam GallagherJames GasparichRobert Gaynes N.Y. Univ. Med. Ctr.Bronx Municipal Hosp. Ctr.Temple Univ. Hosps.Presbyt.-St. Lukes Hosp., ChicagoStanford Univ. Hosps.Michael Reese Hosp., ChicagoU. of Alabama Med. Ctr.U. of Calif. Hosp., L.A.U. of Washington Affil. Hosp.Michael Reese Hosp., ChicagoScott GrahamJoseph HechtSheila HewieBruce HillnerDavid HobanRoger HollandEwald HorwathJoel HowellTrumaine HuntRobert Ike U. of Calif. Affil., IrvineU. of Chicago Hosps.U. of Maryland Hosp.Michael Reese Hosp., ChicagoU. of Colorado Affil. Hosp.Duke Univ. Med. Ctr.Overlook Hosp., N.J.U. of Chicago Hosps.Statten Island Hosp., N.Y.Barnes Hosp. Group, St. LouisAidan W. IpWynn JacksonJohn JacobsenKen JonesWilliam KetchersideJoseph KiernanIrene KomarynskyWalter KoroshetzPaul KremserChristopher Lahr St. Louis Children's Hosp.Roosevelt Hosp., N.Y.C.Baylor Coil. Affil., HoustonBoston Univ. Affil. Hosp.U. of Kansas Med. Ctr.U. of Chicago Hosps.Pennsylvania Hosp.U. of Chicago Hosps.U. of Chicago Hosps.U. of Alabama Med. Ctr. StudentVance LauderdaleLinda LeskyRichard LewanFrank LiebermanGregory MahanJonathan MakielskiJames T. MayesFranklin McCoyDavid McDonaldRonald MeyerLee Patrick MillerAnne MittelstaedtPatrick MoranAllan NadelStephen D. NimerJohn OdellDaniel L. PicchiettiJames PullmanKathryn RiceDean RodmanRobert RosmanFred RossMichael RusliMartin SandersDavid SchaleDonald SchnurpfeilGary SchusterAndrew SchreiberEdward SchweizerHarriet SkomMark SniderFloyd W. SomersPaul SternbergCharles StromJeffrey SugimotoRobert SwiftRoger T okarsRobert S. TomchikSandra TurnerThomas Vander LaanGeorge WattsThomas WebbNeil WeintraubMarvin WeissJacqueline M. WhartonKim WilliamsCharles WittnamJoan WrightKenneth Yaw HospitalPresbyt.-St. Lukes Hosp., ChicagoMichael Reese Hosp., ChicagoRockford Med. Educ. Fdn., III.U. of Chicago Hosps.U. of Calif. Affi I. , IrvineNorth Carolina Mem. Hosp.U. of Illinois Affil. Hosps.U. of Chicago Hosps.Geo. Washington Univ. Hosp., D.C.Northwestern Univ. Med. Ctr.Vanderbilt Univ. Affil. Hosps.Children's Mem. Hosp., ChicagoU. of Colorado Affil. Hosp.Barnes Hosp. Group, St. LouisU. of Calif. Hosp., L.A.Stanford Univ. Hosp.St. Louis Children's Hosp.Postdoctoral Fellow, U. of ChicagoU. of Minnesota Hosp.Massachusetts Gen. Hosp.Michael Reese Hosp., ChicagoHosps. Univ. Health Ctr., Pitts.Medical Coil. of PennsylvaniaBarnes Hosp. Group, St. LouisSt. Francis Hosp., Peoria, III.U. of Missouri Med. Ctr.U. of Colorado Affil. Hosp.Walter Reed Army Med. Ctr.U. of Pennsylvania Hosp.Asst. Ed., lAMA, ChicagoMichael Reese Hosp., ChicagoChestnut Hill-Jefferson, Phila.U. of Chicago Hosps.U. of Calif. Affil., S. DiegoU. of Chicago Hosps.Yale-New Haven Med. Ctr.Massachusetts Gen. Hosp.Columbia, S.c. Richland Cty. Hosp.u. of Colorado Affil. Hosp.Michael Reese Hosp., ChicagoMichael Reese Hosp., ChicagoU. of Calif. Hosp., L.A.N.Y. Univ. Med. Ctr.U. of Pennsylvania Hosp.U. of Illinois Affil. Hosp.Grady Mem. Hosp., AtlantaU. of Washington Affil. Hosp.L.A. Cty. Harbor-UCLAVirginia Mason Hosp., Seattle37News BriefsDr. Steck Chairs BiochemistryDr. Theodore L. Steck, Professor in theDepartments of Biochemistry andMedicine, was named Chairman of theDepartment of Biochemistry April 1.He succeeds Dr. Donald F. Steiner(' 56), the A. N. Pritzker Professor ofBiochemistry, who served as chairmanfrom 1973 to 1979, and as acting chair­man for one year, 1972-1973. Dr. Steckis the fourth chairman of the departmentsince its establishment in 1935.Dr. Steck is an expert in the structureand function of biological membraneswith a particular interest in the proteinsof the human red blood cell membrane.He received his M.D. from Harvard.Medical School in 1964 and came to theUniversity of Chicago in 1970 as Assis­tant Professor of Medicine following afellowship with Dr. D. F. H. Wallach atMassachusetts General Hospital.Dr. Steck was named Assistant Pro­fessor of Biochemistry and Medicine in1973. He was promoted to AssociateProfessor in 1974 and Professor in 1977.He is on the editorial boards of theJournal of Supramolecular Structure,Journal of Cell Biology and Journal ofBiological Chemistry.In 1971 he received a Schweppe Foun­dation Fellowship and is currently a fac­ulty research awardee of the AmericanCancer Society.Darnell Receives Ricketts AwardDr. James E. Darnell, Jr., the VincentAstor Professor at the Rockefeller Uni­versity, received the University ofChicago's Ricketts Award May 7. Theaward honors "outstanding ac­complishment in the field of the medicalsciences. "Professor Darnell, a cell biologist andvirologist, demonstrated that adenovirusDNA is transcribed into very long nu­clear RNA precursor molecules. Sub­sequently, the precursor RN A moleculesare cleaved, and selected portions arefurther modified to form the functionalmessenger RNA. The mRNA codes forthe synthesis of proteins from some 20amino acids.Scientists regard Dr. Darnell's studiesas a model for the synthesis of mRNA inall living cells. It is a key to both normaland abnormal cell development.Dr. Darnell delivered the annual Rick­etts lecture, entitled "Transcription and38 ?-L .:-:......,__Dr. Theodore L. SteckProcessing of Nuclear RNA: Im­plications for Gene Regulation."The award commemorates HowardTaylor Ricketts, a University of ChicagoPathologist who demonstrated thatRocky Mountain spotted fever is trans­ferred to man by ticks. He was the first todescribe the Rickettsia organism thatcauses the disease. Later he found-atthe cost of his life-the related organismthat causes typhus.In MemoriamGeorge K. K. Link (Ph.D. '16)George K. K. Link, Professor Emeritusof Botany, died May 22 in Tucson,Arizona, where he had made his homesince 1956. He was ninety-one.Professor Link, an internationallyknown authority on plant pathology andbotany, graduated with honors from theCollege of the University of Chicago in1910 and completed his Ph.D. in botanyin 1916, with high honors. He joined theDepartment of Botany faculty in 1924and retired as Emeritus Professor in1953.His interest in plants went beyondteaching and he devoted more than fiftyyears to scientific study and conserva­tion programs in the Canadian Rockieswilderness around Lake O'Hara in British Columbia. A naturalist andamateur cartographer, Professor Linkdeveloped a network of trails at Lake0' Hara and also completed a map of thetrails. He was writing a text entitled TheWays of O'Hara on the history, botany,and geology of the region at the time ofhis death.George K. K. LinkHis other writings include a scholarlycollaboration with the late BenedictEinarson of the University's Departmentof Classical Languages and Litera­tures-a translation of the first twobooks of De Causis Plant arum (TheCauses of Plants) of Theophrastus, forthe Loeb Classical Library.Professor Link was born in MountClemens, Michigan in 1888. The familythen moved to LaPorte, Indiana, wherehe graduated from high school beforemoving on to Chicago. For more thantwenty years, following his retirement,Professor Link divided his time betweenhis home in Tucson and visits to his be­loved Canadian Rockies. A memorialservice was held in Tucson, but final dis­position was at Lake O'Hara.Professor Link is survived by threesisters and two brothers: Miss Helene F.Link and Walter K. Link, both ofLaPorte; Dr. Theodore A. Link of Vic­toria, Canada; and Miss Agnes Link andMargret Link Ponomareff, both of Tuc­son.Alumni Deaths'20. Arno Robert Langjahr, Phoenix,Arizona, died 1972, date of birth un­known.'22. Ethel Fanson, Pasadena, Califor­nia, January 9, 1979, age 89.'23. Raymond Green, Chicago, Il­linois, date of death and date of birth un­known.'24. Rebecca H. Mason, Chickasha,Oklahoma, March 27, 1977, age 83.'25. Roy A. Crossman, Lake Wales,Florida, March 7, 1979, age 84.'25. Maurice P. Meyers, Southfield,Michigan, November 20, 1978, age 76.'29. Norbert F. Leckband , Sr., Naper­ville, Illinois, July 5, 1979, age 80.'29. Milton P. Ream, Oakland,California, May, 1976, age 75.'30. Beulah Bosselman, Evanston, Il­linois, June 28, 1979, age 81.'30. Ralph A. Ferguson, Arcadia,California, August 29, 1977, age 75.'30. M. George Henry, Palm Springs,California, May 19, 1978, age 75.'31. Horace W. Doty, Salt Lake City,Utah, February 25, 1979, date of birthunknown.'34. Roger Campbell Henderson,Xenia, Ohio, April 26, 1979, age 73.'34. Marie Agnes Hinrichs, Cham­paign, Illinois, May 11,1979, age 86.'35. Israel Michelstein, Yonkers, NewYork, February 1979, age n.'37. Bernard H. Ailts, Abiline, Texas,December 3, 1978, age 65.'37. Oswald R. Jensen, Sarasota,Florida, died 1978, age 70.'37. Louis G. Kaplan, Chicago, Il­linois, August 18, 1978, age 66., 37. Bernard B. Rosenblatt, Evans­ville, Indiana, March 27, 1979, age 68.'45. Thomas W. Anderson, Santa Ana,California, November 29, 1978, age 57.'52. Thomas A. Johnson, Jr.,Rockford, Illinois, December 30, 1978,age 52.'58. Stephen A. Mitchell, Jr., WindowRock, Arizona, February 13, 1978, age46.'59. Sidney Feldman, Chicago, Il­linois, December 26, 1974, age 49.'68. Marc R. Tet alm an , Columbus,Ohio, June 28, 1979, age 36.Division Alumni Deaths, 16 Ph.D. George K. K. Link, Tucson,Arizona, age 91.Former StaffBengt Hamilton, (Pediatrics, Faculty,'30-'38), July 15, 1979, age 87.Elwood Mason, (Medicine, Faculty,'33-'36), Milwaukee, Wisconsin, Febru­ary, 1979, age 76.Lewis T. Warren, (Anesthesiology,Resident, '66-'69), Evanston, Illinois,June 27, 1979, age 53. Departmental NewsAnatomyPeter H. De Bruyn, Professor Emeritus,spoke at the following seminars: TheNorthwest Center for Medical Educationof the School of Medicine of IndianaUniversity on "The Endothelial Inter­face Between Hematopoietic Sites andthe Vascular Pool"; The Department ofMedicine of the National Jewish Hospi­tal and Research Center in Denver on"Changes in the Random Distribution ofSiliac Acid at the Surface of MyeloidSinusoidal Endothelial Surface at Lo­calized Functional Sites"; and at theThirteenth Annual Meeting of the His­tochemical Society in Keystone, Col­orado on "The Role of Sialated Glyco­proteins in Endocytosis, Permeability,and Transmural Passage in the MyeloidEndothelium.' ,Ben May labDr. Eugene DeSombre, Associate Pro­fessor, chaired a three-day consensusconference on Steroid Receptors inBreast Cancer sponsored by the NationalCancer Institute (NCI) and the Office forMedical Applications of Research, NIH.Dr. DeSombre also is chairman of NCI'sBreast Cancer Task Force.Dr. Elwood V. Jensen, the Charles B.Huggins Professor in the Ben May Labo­ratory and the Departments of Bio­physics and Theoretical Biology andPharmacological and Physiological Sci­ences and the Director of the Ben MayLaboratory, delivered the Walter HubertLecture at the Twentieth Annual GeneralMeeting of the British Association forCancer Research. The meeting tookplace at the University of Glasgow. Hislecture was titled, "Estrophilin-FromHormone Mechanisms to CancerTherapy. "BiochemistryDr. Herbert C. Friedmann, AssociateProfessor in Biochemistry and the Col­lege, participated in the Third EuropeanSymposium on Vitamin BI2 and IntrinsicFactor, in March in Zurich, Switzerland.He discussed aspects of vitamin BI2biosynthesis.Dr. Theodore Steck has been appointedChairman of Biochemistry. Dr. Steck isProfessor in Biochemistry and Medicine.(See News Briefs)Dr. Samuel B. Weiss, Professor inBiochemistry, Microbiology, theFranklin McLean Institute, and the BenMay Laboratory, was one of six faculty of the University elected Fellows of theAmerican Academy of Arts and Scienceson May 9.BiologyAppointment:Dr. Douglas Schemske-AssistantProfessor.Biophysics and Theoretical BiologyAppointment:Dr. Glauco Tocchini-Valentini­Associate Professor.Emergency MedicineAppointment:Dr. Edmund C. Bolton-AssistantProfessor.MedicineAppointments:Dr. Whitney Addington-Professor(Pulmonary Medicine).Dr. Paul M. Arnow-Assistant Pro­fessor.Dr. Arthur S. Banner-Assistant Pro­fessor (Pulmonary Medicine).Dr. Joel E. Bernstein (,69)-AssistantProfessor (Dermatology).Dr. David R. Cave-Assistant Pro­fessor.Dr. Alan Leff-Assistant Professor(Pulmonary Medicine).Dr. Hershel L. Wix-Assistant Pro­fessor (Cardiology).Dr. Eugene Geppert-Assistant Pro­fessor (Pulmonary Medicine).Dr. Leslie J. DeGroot spoke at a semi­nar on "Endocrinology, I 979: WhereAre the New Frontiers?" at the meetingof the Endocrine Society, RockefellerUniversity, New York City, in March.He also discussed "Pre-Graves' Dis­ease" at a symposium on AutoimmuneAspects of Endocrine Disorders in Pisa,Italy, in April. Dr. DeGroot is Professorin Medicine and Radiology, and Directorof the Clinical Research Center.Dr. Joseph B. Kirsner received a 1979Horatio Alger Award in Columbus,Ohio, in May. This is the 30th year of theawards which are given to "living indi­viduals who, by their own efforts, havepulled themselves up by their bootstrapsin the American tradition, and have pro­duced living proof that the free enter­prise system of achieving success stilloffers equal opportunity to all." Dr.Kirsner is the Louis Block DistinguishedService Professor in Medicine.39Dr. Janet D. Rowley (,49) was ap­pointed by President Carter to the Na­tional Cancer Advisory Board for afive-year term. Dr. Rowley is Professorin Medicine, the Franklin McLean In­stitute, and the Committee on Genetics.Dr. John E. Ultrnann, Director of theCancer Research Center and Professor inthe Department of Medicine, presentedthe Adam Thorpe Memorial Lecture atthe University of North Carolina atChapel Hill. The lecture was divided intotwo sections: "Organization and Func­tion of the University of Chicago'sCancer Research Center" and "Non­Hodgkin's Lymphoma, Treatment Sta­tus, and Prospects."Dr. Ultmann has been awarded theEsther Langer A ward for 1979 for hiscontribution to leadership in cancer re­search. The award is presented by theLanger Foundation, an affiliate of theUniversity of Chicago Research Foun­dation. Dr. Ultmann is also AssociateDean for Research Programs in the Divi­sion of the Biological Sciences and ThePritzker School of Medicine.Dr. John E. U/tmannMicrobiologyDr. Bernard Roizman was one of twoUniversity professors elected to the Na­tional Academy of Sciences in recogni­tion of distinguished and continuingachievements in original research. Dr.Roizman is Professor in the Departmentsof Microbiology and Biophysics andTheoretical Biology and the Committee40 on Genetics, and Chairman of the Com­mittee on Virology. His research haslinked the herpesvirus to cervical cancer.NeurologyAppointment:Dr. Samir F. Atweh-Assistant Pro­fessor.Obstetrics and GynecologyAppointments:Dr. Alexander Talerman-Professor.Dr. George B. Maroulis-AssociateProfessor.\/Dr. George B. MaroulisDr. Chin-Chu Lin, Assistant Pro­fessor, received a second place awardfrom the American College of Obstetri­cians and Gynecologists for his paperentitled "The Acid-Base Characteristicsof Fetuses with Intrauterine GrowthRetardation During Labor and De­livery." The Purdue-Frederick Award,consisting of a $1,000 check, was pre­sented at the ACOG's annual meeting inNew York City in April.Coauthors of the paper are Dr. AtefMoawad, Professor in the Departmentsof Obstetrics and Gynecology andPediatrics, Chief of Obstetrics, and Co­director of the Perinatal Center; Dr.Philip Rosenow, Assistant Professor inthe Department of Obstetrics andGynecology; and Philip River, research assistant in the Department of Obstetricsand Gynecology.OphthalmologyDr. Karl J. Fritz ('71), Assistant Pro­fessor, and Dr. Albert Leveille ('78),resident, spoke at the first "Computersin Ophthalmology" conference in SaintLouis. Dr. Fritz presented a paper on"Multiple Scattering in Ocular Media,"and Dr. Leveille's paper was on"Computer-Assisted Diagnosis of Re­tinoblastoma.' ,Dr. Walter J. Jay ('76), senior resi­dent, recently won Nikorr's "ResidentDiagnosis of the Month" award. Nikon,Inc., gives ophthalmology residents acash award and features their diagnosisin Ophthalmology Times. Dr. Jay re­ceived his award for diagnosing papulo­necrotic tuberculid of the skin andsclera.Dr. Frank W. Newell has been namedan honorary member of the section ofophthalmology of the Royal Society ofMedicine, London. Dr. Newell is theJames and Anna Louise Raymond Pro­fe.ssor and Chairman of the Departmentof Ophthalmology. The AmericanOphthalmological Society has awardedDr. Newell the Lucien Howe Medal fordistinguished contributions to his spe­cialty. The medal is the highest honor ofthe Society.PathologyAppointment:Dr. Stephen C. Meredith-AssistantProfessor.Dr. James E. Bowman has been electeda Fellow of the Hastings Center (the In­stitute of Society, Ethics, and the LifeSciences). The Center focuses on ethicaldilemmas arising out of advances inmedicine, biology, and the behavioralsciences. Dr. Bowman is Professor inPathology, Medicine, the College, andthe Committee on Genetics.Dr. Robert W. Wissler (' 48), DonaldN. Pritzker Distinguished Service Pro­fessor and Director of the SpecializedCenter of Research (SCOR) inAtherosclerosis, chaired a panel of basicbiological scientists at the Ford Founda­tion in New York City. They reviewedthe experimental and other research evi­dence that bears on the question of theoptimal blood lipid and cholesterol levelsthat can be expected to prevent the de­velopment of atherosclerosis in humans.Dr. Wissler also has taken part in twomeetings in San Antonio, Texas. Hegave the keynote address at the FirstInternational symposium on the Im-portance of Nonhuman Primates in Car­diovascular Disease. He also was co­director of the Workshop on thePathobiology of Atherosclerosis as a partof the annual SCOR Atherosclerosis sci­entific meetings. Dr. Wissler served as avisiting professor of pathology at theUniversity of Texas at the San AntonioMedical Center.PediatricsAppointments:Dr. Alma Buckner-Chandler-Assis­tant Professor.Dr. Fred Leffert-Assistant Professor.Dr. Barry H. Rich (,74)-AssistantProfessor.Dr. Glyn Dawson, Associate Professorin Pediatrics and Biochemistry, and theJoseph P. Kennedy, Jr., Scholar inPediatrics, was awarded a 1979 Fellow­ship by the John Simon GuggenheimMemorial Foundation for the study of"Biochemical Models for Drug Addic­tion. "Dr. Albert Dorfman ('44), the RichardT. Crane Distinguished Service Pro­fessor in the Department of Pediatrics,was recently installed as president of theAmerican Pediatric Society at theAmerican Board of Pediatrics annualmeeting in Atlanta. Dr. Dorfman is alsodirector of the Joseph P. Kennedy, Jr.,Mental Retardation Research Center,and Professor in the Departments ofBiochemistry and the Committee on Ge­netics and Developmental Biology.Pharmacological and PhysiologicalSciencesDr. Leon I. Goldberg was visiting pro­fessor of the Royal Society of Medicinein London, lecturing on .. PeripheralDopamine Receptors" and "Creativityin New Drug Development: AcademicChallenge." In addition he lectured atmedical schools in London, Edinburgh,Glasgow, and Southampton. Dr.Goldberg was also the William N. Creasyvisiting professor of clinical pharmacol­ogy at Tulane University School ofMedicine, where he delivered the CreasyMemorial Lecture on "The ClinicalPharmacology of Dopam i ne. " Dr.Goldberg is Professor of Medicine andPharmacology and Chairman of theCommittee on Clinical Pharmacology.Dr. Robert J. Dinerstein ('76) has re­ceived a Schweppe Foundation Fellow­ship. The Chicago-based SchweppeFoundation grants thi s career develop­ment award to selected applicants fromarea medical schools for the purpose ofsupporting original research by juniorfaculty members. The grant is $10,000 annually for three years. Dr. Dinersteiri'sresearch is focused on the anatomical 10-calization of neurosecretory substanceswhose levels are known to be influencedby certain classes of drugs. He will alsoprobe the structural effects on the centralnervous system of these drugs duringdevelopment or chronic use. He is As­sistant Professor in the Department ofPharmacological and Physiological Sci­ences.PsychiatryAppointment:Dr. John Raftery (72)-AssistantProfessor.Dr. Jar! Dyrud, Associate Dean forFaculty of the Division of the BiologicalSciences and The Pritzker School ofMedicine and Professor of Psychiatry,participated in a panel discussion on"Cognitive Aspects of Psychoanalysis"at the American Academy ofPsychoanalysis. Dr. Dyrud is a trustee ofthe Academy.Dr. Daniel X. Freedman, the LouisBlock Professor and Chairman of theDepartment of Psychiatry, was one of sixfaculty of the University elected Fellowsof the American Academy of Arts andSciences on May 9. He delivered theAlpha Omega Alpha lecture at EmoryUniversity Medical School in Atlanta,and chaired a session on research at theTwenty-fifth Anniversary Meeting on theFoundations Fund for Research in Psy­chiatry at the National Academy of Sci­ences in Washington, D.C.Dr. Charles R. Schuster, Professor inthe Departments of Psychiatry andPharmacological and Physiological Sci­ences and the College, presented an in­vited address on "The Relationship ofPsychopathology to Drug Abuse," at thePsychiatric Factors in Drug Abuse Con­ference sponsored by the University ofMinnesota in Minneapolis.RadiologyAppointment:Dr. Robert A. Kubicka-AssistantProfessor.Dr. Lawrence H. Lanzi has been ap­pointed editor of Health Physics, the of­ficial journal of the Health Physics Soci­ety. Dr. Lanzi is Professor in Radiology(Medical Physics) and the Franklin Me­Lean Institute.Katherine A. Lathrop, Professor inRadiology and the Franklin McLean In­stitute, presented an exhibit at the Sec­ond International Symposium onRadiopharmaceuticals in Seattle, Wash- ington, in March. The exhibit was titled"Laboratory Studies as a Basis for thePrediction of Radiation Doses and Lo­calization from Technetium Delivered byDifferent Routes."SurgeryAppointments:Dr. Demetrius Bagley-AssistantProfessor (Urology).Dr. Lawrence Pattinger-AssistantProfessor (Orthopedics).Several members of the Burn Centerparticipated in the annual meeting of theAmerican Burn Association held in NewOrleans. Dr. Martin C. Robson, Pro­fessor in the Department of Surgery andChief of the Section of Plastic and Re­constructive Surgery, presented a paperentitled, "Myth, Magic, Witchcraft, orFact-Aloe Vera Revisited," andchaired a panel on "The Management ofthe Difficult Burn Wound." Dr. EdwardJ. DelBeccaro, Surgery Resident, pre­sented a paper on "The Use of SpecificThromboxane Inhibitors to Preserve theDermal Microcirculation after Burning."Dr. John Kucan, Chief Surgery Resident,presented a paper on "Chronic NerveCompression Syndrome at the Wrist inBurned Patients."The following presented papers at the74th Annual Meeting of the AmericanUrological Association held in NewYork: Dr. Edward S. Lyon ('53) As­sociate Professor of Surgery, "FurtherExperience with Ureteroscopy"; Dr.William B. Gill, Associate Professor ofSurgery: "The Catheterized Female RatBladder: A U rothelial-lined Test Tubefor In Vivo Studies of Calcium OxalateCrystallization and Crystal Adhesion";Dr. William E. Kaplan, Resident, "TheFemale Urethral Syndrome: ExternalSphincter Spasm at Etiology": and Dr.Harry W. Schoenberg, Professor andSection Head, "Urodynarnic Studies inBenign Prostatic Hypertrophy" and"The Management of Vesical Dysfunc­tion in Multiple Sclerosis."Dr. Charles J. Gudas, Clinical As­sociate (Associate Professor) in the De­partment of Surgery (Orthopedics),spoke at the American College of FootSurgeons, Southwest Region, on "Footand Ankle Trauma."Dr. Raul Hinojosa, Research Associatein the Section of Otolaryngology, wasappointed advisor-consultant to the NIHCommunicative Disorders ResearchCommittee for the Clinical ResearchCenter Grant Site visit in Minneapolis.Dr. Benjamin Franklin Lounsbury III,Chief Resident in the Section ofOtolaryngology, represented the section41at the Colorado Otology-AudiologyConference and presented a paper enti­tled, "Estimation of Distances of Re­corded Sounds Presented through Head­phones. "Dr. Ralph Naunton, Professor ofSurgery (Otolaryngology), presented aprogram at Northern Illinois Universityentitled, "ENT Diagnosis and Treat­ment: Course on Rehabilitation of theDeaf." He also spoke at Walter ReedArmy Hospital on "Electrocochleog­raphy, Audiograms, and ENT Diagnosisand Noise."Dr. David B. Skinner, Chairman andthe Dallas B. Phemister Professor in theDepartment of Surgery, gave the ThirdAnnual Lester B. Dragstedt MemorialLecture at the College of Medicine of theUniversity of Florida at Gainesville. His'subject was "Neoplasms of theEsophagus. "Zoller Dental ClinicAppointment:Thomas R. Rooney-Assistant Pro­fessor.Frank J. Orland ('49 Ph.D.) was pre­sented the H. Trendley Dean MemorialAward at the 57th General Session of theInternational Association for Dental Re­search Meeting in New Orleans inMarch. Dr. Orland, honored for his re­search in epidemiology and dental caries,is Professor in the Zoller Dental Clinicand the Fishbein Center for the Study ofScience and Medicine.Dr. Thomas M. Graber, Professor inZDC, the Department of Pediatrics, andthe Department of Anthropology, spokeat conferences in France on the princi­ples of craniofacial growth and correc­tion of craniofacial anomalies and re­search on growth guidance. He also par­ticipated in a course for orthodontistsfrom the U.S. and abroad at the Univer­sity's Center for Continuing Educationon "The Frankel Appliance: Utilizationof Muscle Forces and Growth Guidancein the Treatment of Malocclusion."Alumni News1929Harold B. Hanson has announced his re­tirement as emeritus clinical professor inpsychiatry and pediatrics at the Univer­sity of Minnesota Medical School. Dr.Hanson has moved to Edina, Minnesota.42 1933Harry C. Goldberg gave a lecture on theuse of PUV A in atopic dermatitis andprurigo at the International Symposiumon Atopic Dermatitis in Oslo, Norway,in June. Dr. Goldberg practices in PalmBeach, Florida.1936Harold J. Brumm has retired from activepractice but is a medical consultant at theVeterans Hospital in Palo Alto, Califor­nia.1937Charles H. Rammelkamp writes that he isretiring this year as emeritus professor ofmedicine at Case Western Reserve Uni­versity. A professorship has beenestablished in his name at Case andCleveland Metropolitan General Hospi­tal and a two-day symposium on infec­tious diseases was presented by formerfellows and housestaff. Dr. David Grove('70), now at Duke University, andMichael Field and David Kornhauser ofthe University of Chicago participated.1938Robert L. Schmitz delivered the com­mencement address at the Chicago Col­lege of Osteopathic Medicine in June.Dr. Schmitz is chairman of the depart­ment of surgery at Mercy Hospital,Chicago, and professor of surgery at theAbraham Lincoln School of Medicine,which awarded him the DistinguishedService Award in 19761939Ruth I. Barnard retired from the practiceof psychiatry and psychoanalysis in LosAngeles at the end of July and is movingto Guerneville, a small town on the Rus­sian River in Northern California. Shewrites, "I will lead the rustic life with ababbling brook, a redwood grove, amini-orchard, and an absence of big citysmog and hassle."Arthur H. Downing is chief ofophthalmology at the Veterans Ad­ministration Medical Center in DesMoines, Iowa.1940Clarence Hodges, nationally renowed for his work in both prostatic cancer andkidney transplantation, has retired after31 years as head of the division of urol­ogy at the University of Oregon HealthSciences Center. In 1959 Dr. Hodgessuccessfully performed Oregon's firstkidney transplant, the tenth in the world.In 1977 he was named the first recipientof the American Urological Associa­tion's Eugene Fuller Prostate Award. OnAugust 1, Dr. Hodges became head ofthe division of urology at the Universityof Hawaii School of Medicine.Henry S. Kaplan was recently amongthree physicians to receive the first GMCancer Research Prizes. Dr. Kaplanshared the prize with Sir Richard Doll ofOxford University and Dr. George Kleinof the Karolinska Institute in Sweden.Each received $100,000 for his basic andclinical research in cancer. Dr. Kaplan isthe Maureen Lyles D' Ambrogio pro­fessor of radiology and director of theCancer Biology Research Laboratory atStanford University Medical Center. Hewas honored for having "ushered in theera of megavoltage radiation to treatHodgkin's disease." Dr. Kaplan and hiscolleagues were among the first to applytumoricidal doses of high-voltage radia­tion to the lymph nodes with little or nodamage to skin surface using a 5-MEVlinear accelerator he co-developed in1957.1944Arthur Evans writes that he had hoped tobe at his 35th class reunion but becameinvolved in moving his son Charles to theUniversity of Chicago to start his firstyear residency in pathology. Dr. Evans'sthree sons are physicians. In addition toCharles, Arthur III joined the staff of theMayo Clinic in January and William is aresident in urology at the Bowman GrayMedical School. Dr. Evans is professorand director of urology at the Universityof Cincinnati.Edward G. Ference, in addition tobeing a pediatrician and assistant clinicalprofessor at Southern Illinois School ofMedicine in Springfield, lists among hisactivities: president of the SangamonCounty Medical Society, chief medicalconsultant of the Disability Determina­tion Services in the State of Illinois, andmember of the Governmental AffairsCouncil for the Illinois State Medical So­ciety.David S. Fox has just completed aone-year term as president of the IllinoisState Medical Society (ISMS). Dr. Fox ischairman of the department of surgery atWoodlawn Hospital, Chicago, and sec-retary of the hospital's board of direc­tors. He also serves as an ISMS delegateto the American Medical Associationand is a member of the Board of Gover­nors of the Illinois State Medical Inter­Insurance Exchange, the physician­owned insurance company created byISMS to provide malpractice coverage.1945Raymond E. Robertson was electedvice-president of the Board of Trusteesof Riveredge Hospital, Forest Park, Il­linois. Dr. Robertson is a psychiatrist inprivate practice.1946Philip W. Graff retired as AssociateProfessor Emeritus from the Universityof Chicago on June 30. Dr. Graff joinedthe Department of Pathology in 1960. Hehas moved to Liverpool, Ohio, and plansto participate in biological and medicaleducation programs ..John R. Hogness, president of the Uni­versity of Washington in Seattle, hasbeen named president and chief execu­tive officer of the Association forAcademic Health Centers, effectiveSeptember 1. Dr. Hogness was dean ofthe University of Washington School ofMedicine from 1964 to 1969.1951Arnold Tanis, Hollywood, Florida,pediatrician, lectured recently on thesubject "Do I Get a Second Chance t->Relactation" at the Seventh Inter­national Conference of La Leche LeagueInternational in Atlanta, Georgia, wherehe discussed the current status of breastfeeding with pediatricians from aroundthe world. Dr. Tanis is serving a two­year appointment as Florida's chairmanof the American Academy of Pediatrics'Committee on "Speak Up For Chil­dren. "1952Alvan R. Feinstein has recently publisheda book, Clinical Biostatistics. Dr.Feinstein is professor of medicine andepidemiology at Yale University Schoolof Medicine.Willis E. Gouwens, Jr., an anes­thesiologist in Bradenton, Florida, since1965, has a son following in his profes­sion. His son David graduated from the University of Florida College ofMedicine and began an anesthesiologyresidency at the University of Florida inGainesville July 1. Dr. Gouwens alsowrites that he sees Jack Bardolph (' 52)and his wife who have purchased a con­dominium in Bradenton.1960Harold M. Maller was recently promotedto clinical professor of pediatrics, Uni­versity of Southern California School ofMedicine, and chief of staff at ValleyPresbyterian Hospital in Van Nuys. Dr.Maller has a private practice in VanNuys.Guy D. Potter has been appointed di­rector of the department of radiology atLenox Hill Hospital in New York City.A specialist in radiology of the head andneck, Dr. Potter has written 50 articles,is the author of a book in the field, andeditor of two other books on radiology.1963Michael J. Kinney was appointed pro­fessor of clinical medicine and nephrol­ogy at West Virginia University Schoolof Medicine, Charleston division.1965Lowell D. Lutter, clinical associate pro­fessor of orthopedics at the University ofMinnesota, was a featured speaker at theannual meeting of the American Or­thopedic Foot Society meeting in SanFrancisco. As more and more peopletake up jogging and running, knee in­juries are showing up as the most dev­astating associated trauma. A major an­swer to foot-related knee problems inrunners, Dr. Lutter said, is an orthoticinsert in the shoe to help dissipate stress.Dr. Lutter is a long distance runner andhas competed in the last six BostonMarathons.Jacob Pinnas has been promoted to as­sociate professor and director of allergyservice at the University of ArizonaSchool of Medicine. Dr. Pinnas waselected president of the Arizona Societyof Allergy and is a Fellow of the Ameri­can College of Physicians and of theAmerican Academy of Allergy.1966Carl W. Pierce received the $1,000Parke-Davis Award of the American As­sociation of Pathologists at its annual Teacher, Clinician, HumanistThe College, as anyone who hastaught or studied there knows, is achallenge; a Socratic riddle made upof questions to get at the truth. At itsbest it is a guided, informed experi­ence.What Ernest Quantrell, an alumnusand trustee, realized in the 1930s wasthat good teachers made a good col­lege, and that they ought to be re­warded for doing so. And he set asidea prize for teaching.Known since 1954 as the LlewellynJohn and Harriet Manchester Quan­trell Award, it has been given annu­ally to professors in the College forexcellence in undergraduate teaching.This year, Dr. Clifford W. Gurney(' 51), Professor in the Department ofMedicine and the Biological SciencesCollegiate Division, received aQuantrell Award and the $2,500 prizethat accompanies it.Cited for conveying to his students"an appreciation for the science ofbiology as a part of our society," Dr.Gurney was presented with theAward by Edwin W. Taylor, Masterof the Biological Sciences CollegiateDivision, Professor in the Departmentof Biophysics and Theoretical Biol­ogy, and Chairman of the Departmentof Biology. The award was presentedat the 373rd Convocation June 10,43meeting in Dallas in April. The award re­cognizes and encourages research by amember less than 40 years of age. Dr.Pierce, who is professor of pathology,microbiology, and immunology atWashington University, was cited forimmunopathology research contributingto knowledge of cellular immunology, ofcell interactions among immuno­competent cells and macrophages, and ofthe regulation of the immune response.At the meeting, Dr. Pierce delivered alecture on .. Macrophages as Modulatorsof Immunity."1967Stanford Shulman became chief of thedivision of infectious diseases at Chil­dren's Memorial Hospital and professorof pediatrics at Northwestern UniversityCollege of Medicine in Chicago on JulyI. Dr. Shulman had been at the Univer­sity of Florida in Gainesville.1968Hugh N. Hazenfield, in addition to beingchairman of the division of otolaryngol­ogy at Cook County Hospital, has takenon another job as the hospital's associatemedical director.Dominic C. M. Kam has opened a solopractice in general surgery in HongKong.1970Nathan Goldstein III dropped us a note tobring us up to date on his activities... After I V2 years as assistant professor ofpediatrics at Indiana University and 2V:!years as assistant professor of pediatricsat Kansas University, I entered the pri­vate practice of pediatrics in Amarillo,Texas, in December 1977. I am also cur­rently a clinical associate professor in thedepartment of pediatrics at Texas TechSchool of Medicine. My wife Linda and Ihave one daughter, Lisa, age five years."Roxane McKay wrote us that since Jan­uary she has been senior registrar in car­diothoracic surgery at the Hospital forSick Children, Great Ormand Street,London. Prior to that she spent fourmonths as locum senior registrar at theNational Heart Hospital in London. Sheis listed in Who's Who of AmericanWomen and Who's Who in the West.Lawrence A. Okafor has returned tothe department of hematology at theUniversity of Benin Teaching Hospital inBenin City, Nigeria, as a consultant andlecturer in hematology. Dr. Okafor is44 board certified in internal medicine, sub­specialty, hematology.1972Robert J. Dachelet is in private practicein Minneapolis in general and vascularsurgery. He is board certified in generalsurgery.John C. Huntwork is a rheumatologistin Huntington, West Virginia.1973Dwight R. Kulwin started a new positionAugust I as assistant professor in the de­partment of ophthalmology at the U ni­versity of Cincinnati and head of thesection of plastic and reconstructiveophthalmic surgery. He is also chief ofophthalmology at the Cincinnati Veter­ans Administration Hospital.Lee Leserman is a visiting scientist atthe Centre dImmunologie de Marseille­Luminy in Marseille, France, and aFellow of the European Molecular Bi­ology Organization.1975Brian Berger is a fellow in retinal surgeryat the Medical College of Wisconsin inMilwaukee.Judith Hartman has completed a chiefresidency in obstetrics-gynecology atColumbia-Presbyterian Medical Centerin New York and has joined the staff ofKaiser Permanente Medical Center inVallejo, California.Audrius V. Plioplys has begun graduatemedical training in neurology at theMayo Graduate School of Medicine.1976John R. Britton is a perinatology fellowat the University of Colorado MedicalCenter in Denver.James B. Carpenter is a postgraduatein maternal and child health at the Schoolof Public Health, Berkeley, California.John D. Carroll is a fellow in cardiol­ogy at the New England Medical CenterHospitals in Boston.Kathleen Dunne Eggli is a fellow inpediatric radiology at Children's Hospi­tal, National Medical Center, WalterReed Medical Center, in Washington,D.C.Raymond Fish is practicing medicine inUrbana, Illinois, and holds appointmentsas clinical associate at the University of Illinois School of Basic Medical Sciences(Urbana) and assistant visiting professorof bioengineering and electrical en­gineering, also at the University of Il­linois. Dr. Fish's specialty is emergencymedicine.David E. Hall is a fellow in generalpediatrics in an academic developmentprogram at Johns Hopkins Hospital,Baltimore.Walter Hollinger is an internist in pri­vate practice in Chicago.Harold E. Hoyme is a fellow in pediat­ric dysmorphology at the UniversityHospital of San Diego County.Paul Kaplowitz is a fellow in pediatricendocrinology at the University of NorthCarolina, Chapel Hill.Lee Katz is a fellow in nephrology atYale-New Haven Hospital.Stephen F. Kemp is a postdoctoral fel­low in pediatric endocrinology at Stan­ford University Hospital, Stanford,California.Jeffrey C. Laurence is a fellow inhematology-oncology at The New YorkHospital in New York City.Richard W. McDonnell is a fellow ininfectious diseases at the University ofChicago.Thomas M. McFarland is a fellow incardiology at the Hospital of the Univer­sity of Pennsylvania.Thomas J. McKearn is an assistantprofessor of pathology at the Universityof Pennsylvania.Raymond J. Monnat is a resident andfellow in pathology at the University ofWashington in Seattle.Ivan Pacold is a fellow in cardiology atLoyola University, Maywood, Illinois.Philip A. Riedel is a neonatal fellow atMount Zion Hospital and Medical Centerin San Francisco .Robert J. Rothbaum is a GI fellow atCincinnati Children's Hospital.John R. Siever has a pulmonary fel­lowship at Hines Veterans Administra­tion Hospital and Loyola University,Maywood, Illinois.Marcis Sodums is a fellow in the de­partment of cardiology at the Universityof Texas at San Antonio.David O. Staats is the chief medicalresident at Michael Reese Hospital,Chicago.David S. Strayer is an instructor inpathology at Washington University,Saint Louis.Susan Terris is a fellow and researchassociate in endocrinology at the Uni­versity of Chicago.Marcia L. Wendland, has begungraduate medical training at the MayoGraduate School of Medicine. Dr.Wendland took her residency at the Uni­versity of Missouri Medical Center.1977Joseph R. Duba completed one year of afamily medicine residency at Hahne­mann Medical College and Hospital inPhiladelphia and then entered the PublicHealth Service (PHS) corps. He spentthe past year in Cave Junction, Oregon,and will shortly be transferred to a PHSsite in Albion, New York ..David Kapelanski has moved fromNew York University to Houston, Tex­as, for a surgical fellowship research yearat the University of Texas Health Sci­ence Center-Hermann Hospital-withDr. Stanley Dudrick.1978Marc Tetalman, age 35, died June 28 inAtlanta, Georgia, after being shot in arobbery attempt. Dr. and Mrs. Tetalmanwere returning to the Hilton Hotel fromthe Abbey Restaurant where they hadcelebrated their 11 th wedding anniver­sary. Dr. Tetalman, director of nuclearmedicine at Ohio State University, wasin Atlanta attending the Society of Nu­clear Medicine convention. Dr. Tetal­man took his radiology residency at theUniversity of Chicago and remained ayear as an instructor in radiology beforeleaving in 1973 for Ohio State Univer­sity. In addition to his wife Dr. Tetalmanis survived by a 5-year-old son and aone-year-old daughter.1979Class composites are available for $6.00(includes mailing costs) from MedicalCenter Audio-Visual, Box 179, 950 East59th Street, Chicago, Illinois 60637.Make checks payable to Medical CenterAudio- Visual.Former StaffAmeeta K. Bamzai (associate attending,Michael Reese Hospital) has joined thedepartment of pediatrics at Mount SinaiHospital, Chicago, and opened a practicein Park Forest, Illinois.Russell K. Brynes (Pathology, intern/resident, '71-'73; hematopathology fel­low, '73-'75) and his wife Angelita S.Cordero (Anesthesiology, intern/resident, '73-'75) have moved to At­lanta, Georgia. He is an assistant pro­fessor of pathology and laboratorymedicine at Emory University and she isa staff anesthesiologist at the AtlantaVeterans Administration Hospital.Maximo L. Cuesta (Obstetrics- Gynecology, resident, '61-'62) hasclosed his private practice to go intofull-time teaching. He has been ap­pointed assistant professor of obstetricsand gynecology at the University of Vir­ginia School of Medicine and associatedirector of obstetrics and gynecology atRoanoke Memorial Hospital.Michael John Goodman (Medicine, as­sistant professor, '76--'77) is a consultingphysician in Manchester, England, and acoauthor of Ulcerative Colitis publishedby John Wiley, New York City, 1978.Heinz Kohut (Neurology-Psychiatry,resident/faculty, '41-'51) was elected amember of the Austrian Academy of Sci­ences in May. Dr. Kohut is a professoriallecturer in the Department of Psychiatryat the University of Chicago and also isassociated with the Chicago Institute ofPsychoanalysis.Daniel J. McCarty (Medicine, pro­fessor, '67-'74) was installed as pres­ident of the American Rheumatism As­sociation Section of the Arthritis Foun­dation during its 43rd annual meeting inDenver. Dr. McCarty is professor andchairman of the department of medicineat the Medical College of Wisconsin anddirector of the department of medicine atMilwaukee County General Hospital.His research interests center on thestudy of gout and pseudogout for whichhe has received numerous awards. He iseditor-in-chief of the 9th edition of Ar­thritis and Allied Conditions (Lea andFebiger, 1979), long regarded as the de­finitive reference textbook of rheumatol­ogy.Cornelius A. Navor i (Obstetrics­Gynecology, resident, '50-' 52) was re­elected chief of the department ofobstetrics-gynecology at Oakwood Hos­pital, Dearborn, Michigan for a three­year term.Alfred J. Padilla (Medicine, resident,'73- '75) left the endocrinology section atthe Naval Regional Medical Center inPortsmouth, Virginia, July 1 for a posi­tion as assistant professor at UpstateMedical Center, Syracuse, New York.His wife, Mary Padilla (Microbiology,Ph.D. '74) is a veterinary student at Cor­nell University.Harry Prosen (Psychiatry, resident,'58-'59) was elected president of theCanadian Psychiatric Association. Dr.Prosen is professor and head of the de­partment of psychiatry at the Universityof Manitoba in Winnepeg , Canada.David Rabin (Medicine, resident,'58-'60) has been appointed actingchairman of the department of commu­nity and family medicine at GeorgetownUniversity School of Medicine.Herbert S. Ripley (Medicine, intern,'33-'34) was elected president of the American College of Psychoanalysts.Dr. Ripley is emeritus professor of psy­chiatry, at the University of WashingtonSchool of Medicine.Jesus Saldamando (Anesthesiology,resident, '48-'50) was the coordinator ofthe first course for recertification of spe­cialists in anesthesiology in Mexico. Dr.Saldamando is professor of anesthesiol­ogy at the University of Guadalajara.Jack W. Singer (Medicine, intern­resident, '68-'70) has been appointed as­sociate professor of medicine and oncol­ogy and chief of oncology at the Univer­sity of Washington in Seattle. He haswritten a book entitled A Personal Guideto Cancer Care to be published by JohnsHopkins Press in January 1980. Thebook is a layman's guide to cancer, itsprevention and treatment presented froma consumer's viewpoint.Yasukuni Tsuji (Surgery, trainee,'61-'62) has been appointed dean ofNagasaki University School of Medicineand professor of the first department ofsurgery. In 1978 he served as presidentof the Japanese Association for ThoracicSurgery.Carl F. von Essen (Medicine, intern,, 51-' 52) is the leader of Medical PionTherapy Project, a biomedical programto evaluate the effectiveness of pi­mesons in the treatment of cancer. Thefirst patient will receive treatment in1980. He was among the first to ap­preciate the potential of the work devel­oped by Enrico Fermi and Herbert An­derson at the University of Chicago. Dr.von Essen is with the Swiss Institute forNuclear Research in Villigen.Divisional Alumni NewsMaurice R. Hilleman (Microbiology,Ph.D. '44), vice-president and director,virus and cell biology research of Merck,Sharpe, and Dohme Research Labora­tories in West Point, Pennsylvania, hasdeveloped a vaccine against the type 2herpesvirus which is linked to cervicalcancer. The vaccine has successfullyprotected animals against herpes in­fections. Dr. Hilleman is a member of theUniversity of Chicago's Council for theDivision of the Biological Sciences andthe Pritzker School of Medicine.Thomas J. Quinland (Ph.D. '76) hascompleted graduate training at the MayoGraduate School of Medicine inRochester, Minnesota.John C. Yu (Ph.D. '74) has left Har­vard University to become assistantmember, II, at the Scripps Clinic and Re­search Foundation in La Jolla, Califor­nia.45Abstracts of theSenior Scientific SessionNineteen senior medical students fromthe Class of '79 presented reports ontheir research projects at the 33rd SeniorScientific Session held May 30,The ali-day program was chaired byDr, Janet Rowley, Professor in the De­partment of Medicine. the Franklin Me­Lean Institute. and the Committee onGenetics,Chairmen of the four sections of thescientific program were: Dr, WalterFried. Professor in the Department ofMedicine; Dr, Wolfgang Epstein.Associate Professor in the Departmentsof Biochemistry and Biophysics andTheoretical Biology. and Chairman of theCommittee on Genetics; Dean Robert B,Uret z; Vice-President of the MedicalCenter. Dean of the Division ofBiological Sciences and The PritzkerSchool of Medicine. and the Ralph W.Gerard Professor in the Department ofBiophysics and Theoretical Biology; andDr. Frank Stuart, Professor in theDepartment of Surgery (General andTransplantation) and the Committee onImmunology.46 Sequential Changes of SerumCalcium levels Following Thyroidand Parathyroid OperationsStephen BartlettSponsor: Dr. Edwin L. KaplanDiscussant: Dr. Leslie J. DeGrootIt has generally been accepted that sub­total parathyroidectomy is more likely toresult in significant hypocalcemia thanoccurs following single parathyroid glandresection in the treatment of primaryhyperparathyroidism (HPT). Further­more the magnitude of the serum calcium(Ca) changes immediately followingthyroid surgery and after operations onother parts of the body has not beencarefully evaluated previously.Our purpose was to determine the ef­fect of different parathyroid and thyroidgland resections on the postoperativeserum Ca concentration in a group of pa­tients treated at the University ofChicago Hospitals.Fifty-seven consecutive patients (40females, 17 males) who were operated onfor primary HPT by initial neck opera­tion were evaluated. Similarly, 51 pa­tients who underwent thyroid lobectomyfor benign thyroid nodules, 65 patientswho received subtotal thyroidectomy forGraves's disease and 77 patients whounderwent near-total or total thyroidec­tomy were evaluated. In all four groupsthe serum Ca values were determinedbefore operation, on the postoperativeevening, daily until discharge and againon return to clinic. To provide a controlgroup, 12 consecutive patients on whomoperations were performed in areas otherthan the neck were prospectivelyselected and similarly evaluated.Following initial neck exploration forHPT, 52 of 57 individuals (91 percent)were cured. Of those who were cured, 25had single gland resections, 13 had 2glands removed, and 14 had 3 glands re­moved. In cured individuals, a maximumfall in serum Ca of 4.56 ± 0.26 mg/dl(mean ± SE) occurred at 3.14 ± 0.21days. No significant differences in thismaximum fall occurred following 1, 2 or3 gland resections. By careful follow-upof serum Ca changes we were able todistinguish, in the first 72 hr., operativesuccess from failure in the treatment ofprimary HPT.Maximum serum Ca falls after thyroidlobectomy, subtotal thyroidectomy, and"non-neck" surgery were 0.74 ± 0.07mg/dl, 0.91 ± 0.08 mg/dl, and 0.85 ± 0.18mg/dl, respectively. These values do notstatistically differ. However, themaximum fall after total thyroidectomy,1.28 ± 0.07 mg/dl, differs from that forthyroid lobectomy (P < 0.001) and from that for subtotal thyroidectomy (P <0.001).We conclude that: in our patients withHPT, the number of parathyroid glandsremoved does not appear to influence themaximum fall in serum Ca post­operatively as long as an adequateamount of viable parathyroid tissue re­mains. Furthermore, the maximumserum Ca fall after lesser thyroid re­sections is no different than that whichoccurs after other "non-neck" opera­tions. This fall only becomes significantwhen there is trauma to the parathyroidglands as may occur during totalthyroidectomy.Chronic PenicillamineTreatment: A New Modelfor Myasthenia GravisSteven A. BurresSponsor: Dr. David P. RichmanDiscussant: Dr. Joel Brumlik (LoyolaUniversity)To study the pathogenesis of the myas­thenia-gravis-like syndrome that devel­ops in some patients receiving pen­icillamine, we studied guinea pigs treatedwith this agent.On electro myographic testing, 16guinea pigs treated with penicillamine formore than 2 months manifested ed­rophonium chloride (Tensilon)­reversible decremental responses to 30Hz repetitive nerve stimulation. The dec­rement was 8.5 percent ± 1.5 percent(mean ± SEM), which compared with adecremental response of 0.4 percent ±0.85 percent (P < 0.005) for 10 saline­treated control animals. Miniature end­plate potential amplitudes, recordedfrom single cells at the neuromuscularjunction, were significantly reduced in 11treated guinea pigs (0.612 ± 0.01 mv)compared with controls (0.713 ± 0.024mv). Spleen cells of treated animalswere stimulated by purified T. cali­fornica acetylcholine receptor protein(T.c.AChR) (mean stimulation index3.02) but anti-T.c.AChR antibody couldnot be detected by a sensitivehemagglutination assay. These findingsare similar to those seen in humanmyasthenia gravis (HMG).High dose intravenous injection ofpenicillamine into normal guinea pigs didnot induce a decremental EMG re­sponse. Furthermore, penicillamine didnot interfere with the binding of a­bungarotoxin , a curarelike agent, toT.c.AChR. These two observations weretaken as evidence that penicillamine isnot producing a myasthenic response bydirect action at the neuromuscular junc­tion.Since HMO patients demonstratemany autoimmune phenomena, as wellas abnormalities in the thymus gland, ithas been suggested that a defect in im­mune regulation exists in this disease.Penicillamine treatment has also beenassociated with the occurrence of au­toimmune diseases, suggesting a com­mon immune aberration and raising thepossibility that penicillamine producesmyasthenia via its effect on the immuneregulatory system.Multistriatin and Dutch Elm DiseaseWilliam J. ElliottSponsor: Josef Fried, Ph. D.Discussant: Manfred D. E. Ruddat,Ph.D.Recent research has revealed that Dutchelm disease is caused by a fungustCeratocvstus ulmis, which is carriedfrom diseased to healthy trees by a par­ticular beetle, Scolytus multistriatus .Multistriatin is the name given to themost interesting of the three componentsof the volatile attractant of this insect.The active isomer, o-rnultistriatin, hasbeen synthesized by a novel stereoselec­tive method in racemic and both enan­tiomeric forms. The synthesis proceedsfrom acetone, 2-butene-1 ,4-diol, and di­ethylketone to an 85:15 mixture ofa-:y-multistriatin in only 8 steps in 28percent overall yield.The biological activity in laboratoryassays of synthesized (- )-multistriatindid not differ significantly from that ofthe naturally occurring pheromone. The(+ )-antipode, in contrast, showed muchless activity, and was not significantlydifferent from a mixture of the other 2components of the natural pheromone.In field tests of the 2 antipodes, the(- )-enantiomer had more than 200 timesthe activity of the (+ )-enantiomer, andattracted Scolytus beetles very effec­tively even in the presence of endoge­nous pheromone produced by wild bee­tles.In addition to confirming the absoluteconfiguration of natural (- )-a­multistriatin, this study represents anexample of differential biological re­sponses to enantiomers, consistent withchiral pheromone receptors in Scolytusmultistriatus .More practically, multistriatin synthe­sized by this method, in admixture withthe other two (commercially available)components of the natural pheromone, From left, Dr. Richard Miller, Dr. Thomas Jones, Dr. Harry Fozzard, student Jonathan Malielski, andDierdre Makielski.offers prospects for effective sampling,and more importantly, for efficient andecologically acceptable control of thevector of Dutch elm disease.Macrophagelike Propertiesof Retinal Pigment EpithelialCells Revealed by Immuno­Morphologic TechniquesVictor ElnerSponsor: Dr. Thomas SchaffnerDiscussant: Dr. Peter MorseRetinal pigment cells (RPE) were iso­lated from the posterior segments of eyesfrom Macaca mulatta and M. [asicularismonkeys and NZW rabbits by carefullyremoving the sensory retina and me­chanically disrupting the monolayer ofpigment cells in HBSS. After brief in­cubation at 37°C, the glass-adherent RPEcells were incubated with fresh sheeperythrocytes coated with 100 (EA 19O)resulting in RPE cell-EA rosettes.Likewise, RPE cells bound sheep eryth­rocytes coated with 10M and comple­ment (EAC) but not RBCs coated with19M alone.RPE cells also formed rosettes withsheep RBCs aged for I week in vitro butnot with fresh erythrocyte preparations.Transmission and scanning electron mi­croscopy showed unequivocal bindingand phagocytosis of sensitized erythro­cytes by RPE.RPE cells thus manifest functionalproperties of mononuclear phagocyteslike glass-adherence, macrophago- cytosis, and two types of Immune re­ceptors.Effect of Acute and ChronicAdministration of Pentoxifyllineon Microcirculatory Parametersof Rat Skeletal MuscleRick Anthony EspositoSponsor: Dr. Robert L. ReplogleDiscussant: Dr. Christopher K. ZarinsSeveral investigators have recently re­ported on the efficacy of a new xanthinederivative-pentoxifylline-in increas­ing the exercise tolerance, reducing is­chemic rest pain and improving post­stenotic blood flow in patients with pe­ripheral vascular disease. In vitro. pen­toxifylline has been reported to decreasethe screen filtration pressure and bulkviscosity of whole blood. Presumably theclinical effectiveness of this drug is theresult of an enhancement of red bloodcell deformability.To test this hypothesis, we studied theeffect of acute and chronic administra­tion of pentoxifylline on quantitativemicrocirculatory parameters of rat ex­tensor hallucis propius muscle in 2 ran­domized double-blind trials.In the first trial, 20 rats were preparedfor intravital microscopy and baselinevalues of vessel diameter, RBC velocity,and volumetric flow were obtained on asingle arteriole. Subsequently, a 0.2 ccbolus of either 1.0 mg pentoxifylline ornormal saline (control) was injectedintravenously and measurements of di-47From left, students Joan Wright and Roger Tokars talk with Dr. Janet Row­ley (,49), chairman of the 1979 Senior Scientific Session.ameter, velocity, and flow made at 5-minute intervals for 1 hour. During thisperiod, there were no significant dif­ferences (P > 0.05) between the treatedanimals and controls suggesting that theclinical effectiveness of this drug is notdue to a peripheral vasodilation.In the second trial, 20 rats were di­vided into 2 groups of 10. Each groupwas randomized to receive intra­peritoneal injections of either 1.0 mg ofpentoxifylline or an equivalent volume ofsaline every 12 hr. for a minimum of 7days. The animals were then individuallyprepared for intravital microscopy andmeasurements of microcirculatory pa­rameters were made on several trans­verse arterioles and capillaries. Meanvalues of arteriolar and capillary diame­ters, RBC velocities, and volumetricflows were determined for each group.There were no significant differences (P> 0.05) between the treated and controlgroups.Although pentoxifylline treatment hasbeen noted to increase the red blood celldeformability of normal subjects, wehave not demonstrated any effect of thisdrug on microcirculatory blood flow pa­rameters in the nonischemic skeletalmuscle of the rat. The clinical efficacy ofthis drug may not be due to an improve­ment of blood flow through the microcir­culation. More likely, however, is theconclusion that the enhancement in eryth­rocyte deformability caused by pen­toxifylline is only significant in the mi­crocirculation of the ischemic extremity.We hope to further investigate the role ofthis drug on microcirculatory blood flowin the ischemic hind limb of the rat.48 From left, Charles Strom, Aidan to, and Christopher Lahr.Protective Effects ofCycloheximide on Cell DamageInduced by Cytotoxic AgentsRobert L. FineSponsor: Dr. Clifford GurneyDiscussant: Dr. Carol RichmanOne of the major problems in currentcancer chemotherapy is toxicity to nor­mal proliferating cells in the body like thebone marrow, intestinal crypt, and basalepithelial cells. Thus, successful therapyis dependent on a differential effect ofincreased toxicity to malignant versusnormal proliferating cells.Pardee originally observed that certainprotein synthesis inhibitors, like cy­cloheximide, could reversibly stop pro­liferation of normal hamster kidney cellsexcepting those transformed by on­cogenic virus. This allows for increaseddifferential toxicity of the malignant ver­sus normal cells in tissue culture andprovides the basis for selective protec­tion of the normal cells against lethalchemotherapy that is cell cycle specific.The following experiments supportthis important concept in vivo and invitro.Vinblastine (VLB), an agent thatmainly inhibits microtubule formationin mitotic spindles, and CytosineArabinoside (ARA-C), a nucleosideanalogue of cytosine, are phase-specificdrugs that are only toxic to phases M andS, respectively, in dividing cells, and arenot toxic to resting cells (Go). Cy­cloheximide (CHX), a protein synthesisinhibitor, acts mainly on early Gl.When a single large dose of VLG (5 mg/kg) was given with and without CHXat 1.0 rng/kg, the group receiving VLBalone had a 5 percent depression of whiteblood cells (WBC) at day 3 and 25 per­cent depression at day 5. By comparison,the group receiving both drugs had a 2percent WBC depression at day 3 and aspercent depression at day 7. A controlgroup and a group receiving CHX aloneshowed no difference in WBC. Plateletswere also assayed using a coultercounter and showed essentially no dif­ference between the VLB alone andVLB/CHX groups.In a toxicity study, a lethal dose of 100percent (Ll.ri oo) (VLB = 20 rng/kg) wasgiven to the control and experimentalgroups. By day 9, in the group receivingVLB alone, all had died, while the groupreceiving CHX 5 minutes before receiv­ing VLB, showed 28 percent survival.When the two drugs were administeredtogether, it resulted in a 64 percent sur­vival. The last finding raised the possi­bility that CHX might be chemicallyinterfering with the action of VLB and aset of experiments was designed to an­swer that question.U 121 0 leukemia is a well-characterizedand well-studied lymphocytic leukemiathat grows in the same strain of miceused in our previous experiments.A control group and group receivingCHX alone had a mean survival of 8 dayswhen injected with 105 cells.Groups of the 15 mice receiving VLBalone at doses of 1.0, 1.5, 2.0, and 2.5rng/kg on days, 1,3,4,7,9, and 11 had amean survival of 12.3, 14.5, 14.3, and13.0 days, respectively. Other groups reoceived CHX and VLB injections 5 min-utes apart or a mixture of CHX andVLB.There were no significant differencesin life span among groups receiving VLBalone, CHX and VLB, or VLB mixedwith CHX. This supports the notion thatCHX does not interfere with the anti­neoplastic effects of VLB in the U 121 0leukemia system.To assay the effects of CHX in vitro,human bone marrow cultures were usedwith ARA-C, a cytotoxic phase-specificagent, according to the assay methods ofRichman et al. and McCulloch et al.Three normal volunteers were used andeach experiment was performed in qua­druplicate.The assays tested the toxicity ofARA-C-with and without CHX-oncolony formation in culture by humangranulopoietic progenitor cells (CFU-C).In the first two experiments the mar­row was incubated with 0.2 fLg/mlARA-C ::!: CHX at 5fLgimi for 1 hr. andthen plated. ARA-C alone, in both mar­row cultures, had an average 68 percentCFU-C survival. If CHX was added thesurvival increased to 100 percent.A third marrow culture was incubatedfor 3 hr. with ARA-C at 10 fLgiml ::!: CHXat 5 fLgiml. Here, ARA-C alone had a 22percent survival. Thus, a substantial re­duction of cytotoxicity to normal mar­row granulopoietic progenitor cells couldbe mediated by CHX in this assay sys­tem.In summary, normal proliferating cellscan be protected from the toxicity of thephase-specific drugs VLB and ARA-C byCHX both in vivo and in vitro. CHX pos­sibly increased the differential effect byreversibly stopping normal cells incycle-malignant cells continue to pro­liferate and thus are more prone to cellkillings by cytotoxic agents.Origin and Behavior of TQ-STSegment Deflection DuringMyocardial IschemiaRoger P. HollandSponsor: Dr. Morton ArnsdorfDiscussant: Dr. Rory W. ChildersFollowing acute coronary occlusionTQ-ST segment deflection changes areobserved in the electrocardiogram in­dicating the presence of myocardial is­chemia.This study has demonstrated that themagnitude and polarity of these de­flections are determined primarily by: 1)differences in transmembrane potentialat the boundary between normal and is­chemic tissues established during di- astole and systole due to the accumula­tion of a depressant factor in the is­chemic region; 2) the position of the rec­ording electrode with respect to the is­chemic tissue boundaries; 3) the area ofischemic involvement; 4) the transmuralshape of ischemic involvement; and 5)the thickness of the ventricular wall atthe boundary.Spatial factors that influence the is­chemic TQ-ST segment deflection maybe investigated quantitatively using solidangle analysis. Predictions obtained fromthis analysis may then be tested and vali­dated in the intact pig heart, a model thatpermits production and measurement ofa standardized and well-defined area ofischemic involvement.Nonspatial factors (including electro­lytes, antiarrhythmic agents, and heartrate) influence the TQ-ST deflection byaltering the transmembrane potentialgradient existing between normal and is­chemic regions. These factors are beststudied with an in vitro guinea pig ventri- underlying the origin and behavior of theischemic TQ-ST segment deflection.Protection of Marginal IschemicMyocardium by Intra-aorticBalloon Counterpulsation:Alterations in TransmuralDistribution of EarlyIschemic ChangesJoel D. HowellSponsors: Drs. John Lamberti andSeymour GlagovDiscussant: Dr. Wolfgang SchrautLigation of the left anterior descendingcoronary artery for 20 min. was used inconjunction with epicardial electrocar­diography and a standard method ofperfusion fixation and myocardial sam­pling to study the effects of intra-aorticballoon counterpulsation (lABCP) on theFrom left, guest Melicien Tettambel and students William Elliott and Victor Elner.cle preparation that permits simultane­ous determination of both intracellularand extracellular potentials and parallelcomputer simulation studies.All experimental results agreed withtheoretical formulations and helped tofurther elucidate the basic mechanisms distribution of ultrastructural ischemicchanges.Eight dogs were maintained on IABepduring the ischemic period while 6 otherswere subjected to ischemia withoutJABCP. Hemodynamic findings wererecorded and epicardial ST segment49From left, Robert Swift, Jeffrey Sugimoto, and Stephen Bartlett.From left, Rick Esposito and Joel Howell.(Epi-ST) elevations were determinedover ischemic (I) and nonischemic (NI)zones. Perfusion fixation at physiologicpressures provided a specimen suitablefor transmural sampling from endocar­dium to epicardium at O.I-cm intervalsfrom both I and NI zones in the sameheart.Ultrastructural ischemic changes weregraded according to precise morphologiccriteria. IABCP and non-IABCP groupsdid not differ in distribution or extent ofEpi-ST elevations or in hemodynamicfindings; proximal flow was reduced inboth groups by an average of 39 percent.In the non-IABCP group a transmuralgradient of ultrastructural injury, in­creasing in severity from epicardium toendocardium was noted both in the cen­ter and in the periphery of the I-zonesites.In the IABCP group the same gradientof injury was observed in central I-zonesamples, but peripheral samples showedstriking preservation of the sub­endocardial myocardium despite the per-50 sistence of ischemic injury in the mid­myocardium. These findings providemorphologic evidence for increased flowto subendocardial myocardium at themargins of the ischemic zone.Abnormal PhospholipidMetabolism in Huntington'sDisease FibroblastsAidan IpSponsor: Dr. Marvin ZelkowitzDiscussant: Dr. Barry G. W. AmasonHuntington's disease (HD) is an au­tosomal dominant disorder of uncertainetiology with onset around the third dec­ade of life and relentless progression ofchorea and dementia. Activities ofglutamic acid decarboxylase and cholineacetyltransferase are decreased in thebasal ganglia, probably secondary to cellloss in this area.Recent evidence suggests a generalmembrane abnormality as the underlyingdefect in HD. Lymphocyte capping is in­creased, scanning electron microscopyof erythrocytes shows increased numberof stomatocytes, and electron spin re­sonance study shows altered conforma­tion and/or organization of erythrocytemembrane proteins. Fluorescent labelingof fibroblasts shows increased bindingsites or quantum yield for the fluorescentlabel.Choline and lecithin, as precursors forthe neurotransmitter acetylcholine, havebeen used to treat HD with equivocalsuccess. The presence of phosphatidyl­N-monomethylethanolamine, a methy­lation intermediate in the synthesis ofphosphatidylcholine from phos­phatidylethanolamine, is associated with a major decrease in membrane viscosityand a concomitant twofold increase inL-isoproterenol-sensitive adenylatecyclase activity. An abnormality ofphospholipid metabolism might explainthe observed membrane abnormality andthe debilitating course in HD.Age and passage matched fibroblastswere used to study radioactive label up­take into membrane phospholipids. One­and three-day ethanolamine incorpora­tion into methylated phospholipids as apercentage of phosphatidylethanolaminelabel uptake (% ± sd) was measured.Day 1 Day 3Normal (n=2)HD (n=2)(2-tailedcomparison) 4.01 ± 1.752.40±0.078 3.36±0.0215.88±0.56P<0.35%±sd P<0.025There was no difference in serine up­take but slightly decreased acetate andcholine uptake into phospholipids wasobserved in HD fibroblasts. These ex­periments are consistent with an abnor­mality of phospholipid metabolism,perhaps a phosphatide methyltransferasedeficiency in HD fibroblasts.Receptor and Barrier Propertiesof Biological Membranes:Two Short StudiesWalter J. KoroshetzSponsors: Drs. Arthur Rubenstein andRamon R. LatorreDiscussant: Howard S. Tager, Ph.D.The studies described treat 2 aspects ofthe cell membrane: 1) the barrier func­tion of biological membranes with re­spect to a charged particle, and 2) thespecific binding properties of a mem­brane protein, the insulin receptor.The study of the carrier ion complex asit traverses a bilayer membrane offerseasy insights into the principles whichgovern the interaction of a polar milieuand a lipid barrier. This interaction formsthe basis for compartmentalization in cellbiology. My experiment focused on themechanism of action of a valinomycinanalogue, PV-Iac, in the transport of K+across artificial bilayers. Besides probingthe nature of biological membranes, car­rier studies have application to systemssuch as A TP-ase linked pumps orvoltage-dependent gating mechanisms inwhich it is thought that lipophilic chargedparticles are transported across mem­branes.My second study considers the bindingproperties of the insulin receptor onhuman red blood cells. The receptor hasbeen shown by others to be a site of theregulation of insulin action. An assay fordetermining receptor number and affinityin an easily obtainable human tissuemight well be expected to have greatbenefits in the study of clinical groupswith altered metabolic status. I examinedthe effect of P on binding and dissocia­tion of insulin, the negative cooperativityeffect, and insulin degradation and con­cluded that the human RBC receptor hasproperties much like those described for were entered by vascular lab techniciansor physicians on high-speed, interactiveCRT terminals in response to multiple­choice or fill-in questions which weredisplayed on the terminal screen. Thecomputer asked questions that were de­termined by the user's previous answersand by "branching logic trees" that werenot seen by the user but were stored withthe displays.Relevant history, physical findings,risk factors, vascular lab results, and an­giographic findings were all stored asEnglish language phrases and numbersand grouped according to patient, type ofFrom left, medical alumni president Dr. Joseph Skom ('52), and students James Pullman and StevenBurres.other cell types and I expect that it willbe a useful clinical marker in the future.Computerization ofVascular Lab RecordsChristopher J. LahrSponsors: Drs. Christopher Zarinsand Melvin GriemDiscussant: Dr. Gerald MossA computer system composed of a Di­gital Equipment PDP 11145 computer andFortran programs was developed tostore, evaluate, and correlate the resultsof vascular lab and arteriographicstudies. Test results and patient data information, and date. Data were thenanalyzed by "string" handling Fortransubroutines which search and comparestrings of alphabetic and numericcharacters.Following data entry, patients weregrouped by angiographic lesion and theirarterial studies were compared. For­mulas were developed for predicting thelocation and severity of lesions. Com­puter analysis of vascular lab studiesbased on these formulae was performedand accuracy compared to manual as­sessment.Analysis of multiple variables in largepatient groups will determine the accu­racy and prognostic significance of arte­rial exams, identify subgroups of thepopulation at particular risk from diseaseor surgery, and may improve the criteria used to evaluate the tests. Such large­scale analysis, not practical manually,will contribute to our understanding ofthe etiology and course of vascular dis­ease and the use of noninvasive tech­niques in its evaluation.Computer Model for ConductedAction Potential in CardiacPurkinje Fibers: Effect ofPotassium Concentration onConduction VelocityJonathan C. MakielskiSponsor: Dr. Harry A. FozzardDiscussant: Dr. Morton ArnsdorfStudies of cellular electrical events in thefibers of the cardiac conduction systemcan be categorized into two cases: I) theuniform case in which the entire fiberfires at once, or 2) the conducted case inwhich the action potential is propogateddown the fiber.The voltage clamp method gives in­formation on the membrane and cableproperties of experimental fibers onwhich to base mathematical models. Theuniform case has been well studied inthis way. The conducted case, which isimportant in studying mechanisms of ar­rhythmias and possible treatment, hasbeen less well studied.Using the elements of previously pub­lished models for both cardiac and nervefibers, a new model was synthesized andprogrammed on a computer to simulatethe conducted action potential. Parame­ters required for the simulation weretaken from actual fiber measurements.Values computed, like conduction ve­locity, were comparable to actual mea­surements.Resting membrane potential was ex­perimentally altered by manipulatingexternal potassium concentration, thusmodeling a condition found in clinicalpractice. A biphasic effect on conductionvelocity previously observed in sheepfibers and whole dogs was reproduced.Using numbers generated by the model,and not available experimentally, it wasshown that this effect could be explainedon the basis of the interactions of mem­brane sodium current and membrane ca­pacity current.Such insights contribute to the theoryof action potential conduction in theheart. Moreover, future experimentswhich mimic pathological events, egoissue inhomogeneity due to ischemia,may provide a unique view on theseclinical problems.51From left, Professor Manfred Ruddat, Dr. Wolfgang Epstein, and medicalalumni president-elect Dr. Frank Fitch ('53).Assembly ofMyosin on PolysomesJames M. PullmanSponsors: Albert V. Crewe, Ph.D.and Dr. Donald FischmanDiscussant: Dr. Radovan ZakAlthough the role in contraction of themyofibril of skeletal and cardiac muscleis understood in detail at the molecularlevel, little is known about the formationof this highly ordered structure from itsconstituent proteins.One particular problem of interest ishow the protein myosin assembles firstfrom two heavy and four light peptidechains and then aggregates to form theforce-generating portion of the myofibril,the thick filament. Electron micrographsof thin sections of developing musclefrom various sources show no spatialproximity of large polysomes, whichpresumably synthesize myosin heavychains, to thick filaments in partiallyconstructed myofibrils.This suggests that myosin assemblyoccurs in stages involving molecularintermediates not detectable in micro­graphs of thin sections. The earliest pos­sible intermediate would be dimers ofmyosin heavy chains formed while thepeptides were being synthisized onpolyribosomes. This is a testablehypothesis since myosin synthesizingpolysomes can be purified from em­bryonic chick muscle on the basis oftheir large size, and an assemblingmyosin molecule emerging from a ribo­some would be visible in electron mic­rographs of platinum-shadowed prepa­rations.First, the presence of myosin nascent52 peptides on polysomes was verified usinga rabbit anti-chick myosin heavy chainIGG. This antibody bound specifically toonly the large, presumptive myosin poly­somes, but was unbound when the poly­somes were treated with puromycin, anascent peptide-releasing agent. How­ever, the antibody bound to all muscle­derived polysomes unless they were pre­viously washed with a 1 percentdeoxycholate-triton X-IOO detergentmixture. This shows that under the con­ditions of isolation, myosin heavy chainsstick to ribosomes after their synthesis iscompleted.Electron microscopy of unwashedmyosin polysomes verified this latter ob­servation, since many molecules with thecharacteristic morphology of myosincould be seen emerging from large poly­somes. No such molecules could be seenon detergent-treated polysomes,although the myosin nascent peptidescould be detected on the surface of ribo­somes in electron micrographs of poly­somes treated first with antimyosinheavy chain IGG and followed by ferritinconjugated goat anti-rabbit IGG. Sincethe detergents used do not affect thestructure of isolated myosin molecules,these results imply that myosin does notfold into its native form during its syn­thesis on polysomes.The first stage of assembly musttherefore occur sometime after synthe­sis, either on the ribosomal surface orelsewhere in the cytoplasm. This work,in conjunction with other recent studieson the synthesis and turnover of myosinpeptide chains, further suggests that arate-limiting and conceivably regulatorystep involves an assembly intermediateof unknown molecular configuration. Pathophysiology of ExperimentalHyphema ClearancePaul Sternberg, Jr.Sponsor: Dr. Ramesh TripathiDiscussant: Dr. Robert R. ChilcoteHyphema, or hemorrhage into the an­terior chamber of the eye, is a commonophthalmological problem frequently re­sulting from direct injury to the eye. Ele­vations in intraocular pressure followinghyphema are often seen, particularlywith hyphemas occupying greater than50 percent of the anterior chamber.However, no experimental studies havebeen undertaken to correlate the timecourse and the etiology of the elevatedintraocular pressure with the amount ofhyphema.To characterize hyphema clearance, Istudied the effect of red blood cell perfu­sion into the anterior chamber on facilityof outflow in freshly enucleated rabbiteyes. I used normal RBCs and sicklecells, the latter known to have decreaseddeformability.The eyes were perfused with autolo­gous and human red blood cells at a con­stant physiological pressure with the ratemonitored by changes in the weight ofthe perfusate reservoir. Both types ofblood cells demonstrated a characteristic"crowding phenomenon" with a steadydrop in outflow facility over the initial 30min., stabilizing at a coefficient ofoutflow significantly lower than the con­trol value. This pattern was seen with 50and 100 percent hyphemas but not inhyphemas occupying less than 50 per­cent of the anterior chamber. Despite thedecreased deformability of the sicklecells, they showed a facility patternsimilar to normal human and autologouserythrocytes.These studies show a significant com­promise in aqueous humor clearanceshortly after the initial bleed, suggestingthat surgical intervention may be in­dicated more often than with blackballhyphema. In addition, sickle cell patientsshould not be at a greater risk of compli­cations of hyphema than non-sicklers,Amplification ofDNA Sequences DuringChick CytodifferentiationCharles M. StromSponsor: Dr. Albert DorfmanDiscussant: Hewson Swift, Ph.D.Limb bud mesenchymal cells from stage24 chicken embryos differentiate inchondrocytes when cultured at confluentdensities. If the thymidine analogue 5-bromo-2' -deoxyuridine (BrdU) is presentat a concentration of 32 J.LM during theinitial 48 hr. of culture, chondrogenicdifferentiation is irreversibly blocked.[3H]BrdU was preferentially in­corporated into moderately repetitiveDNA sequences by stage 24 limb budmesenchymal cells grown for the initial48 hr. at confluent density in the pres­ence of 32 J.LM BrdU. The [3H]BrdU wassubsequently excised from the genome atthe rate of 23 percent per day.A radioactive DNA probe, isolatedfrom limb bud cells cultured in the pres­ence of 32 J.LM BrdU and [3H]BrdU (33J.LCi/ml) for 48 hr., was used in re­association reactions with excess non­radioactive DNAs prepared from em­bryonic tissue and cultures at variousstages of chondrogenesis. The genomesof chondrocytes obtained from limb budcultures or embryonic sternae containedmore probe-complementary sequencesthan did the genomes of noncartilagecells (liver, brain, and heart), stage 24limb bud mesenchymal cells, or cells oflimb bud cultures that had been irrever­sibly inhibited from differentiating byBrdU.The differentiation of day 5 chickneuroretinal cells in organ culture is alsoirreversibly inhibited by BrdU. A[3H]BrdU probe was prepared fromneural retina organ cultures and wasused to demonstrate amplification ofDNA sequences during chick neuralretina differentiation. Reassociation ex­periments of neural retina and cartilageprobes with differentiated cartilage andneural retina DNA demonstrated that atleast some of the amplified sequences aretissue specific.Role of the Stomach inPostprandial Calcium HomeostasisJeffrey SugimotoSponsor: Dr. Edwin L. KaplanDiscussant: Dr. Thomas M. JonesIntuitively, one would expect that fol­lowing a meal containing calcium (Ca)the serum Ca level would rise due togastrointestinal absorption of this ion.However, the opposite appears to betrue. This fall in serum Ca was oncethought to be a manifestation of thePTH-calcitonin homeostatic axis, asprotection against post-prandial hyper­calcemia and maintenance of a constantserum Ca. With the discovery of newgastrointestinal peptide hormones andour understanding of their relationship tocalcium homeostasis, the simple notion From left, Dr. Julian Rimpila ('66) and students Robert Fine and WalterKoroshetz.that PTH and calcitonin exclusivelycontrol serum Ca levels is no longer held.In order to clarify whether or not agastric factor influences Ca homeostasiswe studied: 1) the effect of a regulatedfeeding schedule on the serum Ca level inrats, and 2) the effect of a gastric acidinhibitor on the serum Ca levels duringthe regulated feeding period.Fifty male Holtzman rats wereadapted to a feeding schedule in whichfood was available for 9 hr. and withheldfor 15 hr. Concomitantly, the dark periodcorresponded to feeding and the lightperiod to the unfed cycle. Tap water wasavailable ad libitum. This regimen re­sulted in a daily rhythmic serum Cafluctuation related to the onset of feed­ing. A 9-11 percent fall in serum Ca wasobserved in the period beginning 4 hr.prior to the onset of feeding (P < 0.005).This level remained low for 2 hr. into theregular feeding period.Metiamide, an Hz-receptor antagonistwhich has been shown to inhibit gastricacid secretion in rats, was added to thewater during the light/unfed period. Thevolume of water or water and metiamideingested per rat was the same. A dose ofbetween 5-10 mg of this drug wasthereby administered to each rat. On thisregimen, the anticipated fall of serum Caprior to feeding was completely inhibitedand no variation was seen in the serumCa after eating began.This study demonstrates that rats con­ditioned to a feeding regimen exhibit afall in serum Ca prior to the onset offeeding and that by inhibiting gastric acidsecretion one can abolish this "antic­ipatory" calcium fall. In similar studiesit has been reported that there was not asignificant rise in either gastrin or cal­citonin until well into the feeding period.These prior data together with our studysuggest that a gastric factor related toacid secretion or due to acid secretion itself plays an important role in serumcalcium homeostasis in the rat. Whetheror not this phenomenon plays aphysiologic role in man will requirefurther evaluation.Modulation of Pituitary andHypothalamic Hormone Release byMorphine and Opiate PeptidesRobert M. SwiftSponsor: Dr. Richard J. MillerDiscussant: Phillip C. Hoffmann, Ph.D.Since the recent discovery of the endor­phins and enkephalins, peptides withopiate agonist activity, intensive in­vestigations have been carried out inorder to define the functions of thesepeptides in the nervous system. Onesuch important role may be in the controlof the release of hormones from thepituitary gland. Narcotic drugs such asmorphine affect the secretion of severalpituitary hormones, including prolactin,growth hormone, vasopressin, andACTH.Since the main control of pituitaryprolactin secretion is mediated by the in­hibitory effects of hypothalamicdopamine neurons, we examinedwhether the releasing effects of opioidson prolactin were mediated by effects onhypothalamic dopaminergic systems.Morphine (5 and 15 mg/kg i.p.) or(D-AlaZ, D-Leu5)-enkephalin (25 J.Lg) or,B-endorphin (15 J.Lg) injected into the lat­eral ventricle significantly reduced thedopamine turnover in the median emi­nence of male rats. Prior administrationof the opioid antagonist naloxone effec­tively blocked the effects of morphineand the opioid peptides.One important property of opioids istheir ability to induce tolerance and53physical dependence. In rats madetolerant/physically dependent by re­peated administration of morphine, the(10 mg/kg s.q.) to increase serum pro­lactin levels and to decrease dopamineturnover in the median eminence wasfound to be greatly attenuated.In conclusion, the ability of opiods toalter dopamine turnover in the medianeminence and other brain regionssuggests that the actions of endogenousopioids may frequently be mediated byinteraction with brain catecholamines. Inparticular, opiates and opioid pep tidesincrease prolactin release by inhibitingthe release of dopamine from nerve ter­minals in the median eminence.Combined Therapy in PatientsTreated for Mycosis FungoidesRoger P. TokarsSponsor: Dr. Melvin GriemDiscussant: Dr. Joseph M. BaronIn a comprehensive mycosis fungoidesprogram, 60 patients were seen withpathological diagnosis of mycosis fun­goides. Forty-four patients with ad­vanced disease were referred for radia­tion therapy. Three treatment techniqueswere identified in which 14 patients weretreated with localized fields using elec­trons or whole body electron beam withdoses less than 3,000 rads, 21 patientswere treated using the Stanford tech­nique with tissue doses of between 3,000and 4,000 rads, and 9 patients weretreated with 6 cycles of MOPP or COPPfollowing the electron beam.Actuarial survivals at 1 yr. for the 14patients with localized electron beamwas 45 percent, whereas the actuarial sur­vival for patients treated with wholebody electron beam is 83 percent, and100 percent for those patients receivingwhole body electron beam followed byfour-drug chemotherapy. The recur­rencefree interval for these groups cor­relates with these observations. A cen­tral nervous system recurrence has beenobserved in the combined therapy group.Scanning Electron Microscopyof Infective EndocarditisJoan WrightSponsor: Dr. Robert H. KirchnerDiscussant: Dr. Seymour GlagovInfective endocarditis is a well-knowncomplication of intravenous drug abuse.54 Endocarditis in the addict tends to beacute, most often occurring on cardiacvalves without history or evidence ofprevious pathology.Proposed explanations for these in­fectious attacks on normal valves includefrequent exposure to large inoculums ofvirulent organisms, induction of sys­temic immunologic reactions, or directdamage to endothelium by street heroingrossly contaminated with adulterantssuch as starch or lactose and filteredthrough cotton strands before injection.As part of a study of the developmentof infective endocarditis in narcotic ad­dicts, scanning electron microscopy(SEM) was used to examine the surfacecharacteristics of human and animalheart valves obtained at autopsy. Severalsets of grossly normal valves from ad­dicts and nonaddicts as well as valveswith infective and nonbacterial endocar­ditis were selected for study. Valveswere formalin fixed and processed forSEM with samples from adjacent regionstaken for light microscopy.Normal human heart valves obtained6-18 hr. postmortem showed preserva­tion of endocardium with some wrinklingdue to valve shrinkage during process­ing. At high magnification, endothelialcells formed a cobblestone pattern on the valve surface. Cells showed variable de­grees of postmortem autolysis with cor­responding shrinkage of individual cellsand retraction of cell junctions producinggaps between cells. There was no evi­dence of significant antemortem injury tovalves and no significant difference be­tween valves of addicts and controls.A marked difference was noted incases of active infective endocarditis. BySEM there was clear delineation be­tween normal endothelium and the reg­ion of endocarditis, which displayed amixture of stromal connective tissuefibers, fibrin, and blood cells. In onevalve numerous bacteria (cocci inchains) appeared on the surface adherentto the collagen-fibrin matrix. A case ofhealed non bacterial endocarditis demon­strated smooth papillary surfaces cov­ered by irregularly shaped endothelialcells of varying sizes without surfacefibrin or exposed stroma.These results suggest that SEM shouldbe useful in the study of experimentallyinduced endocarditis, for surface dif­ferences in endocardium are easily rec­ognized. Large surface areas can beanalyzed for proportions of fibrin,platelets, leukocytes, exposed stromalconnective tissue, and bacteria in lesionsat various stages of development.Award WinnersRoger Hal/andTwo cash awards were given tosenior students for exceptionalpresentations of their scientific re­search at the 33rd Senior ScientificSession. Awards were announcedat the Medical Alumni dinner June15 honoring the graduating class.Dr. Roger Philip Holland re­ceived the Medical Alumni Prizefor best oral presentation. Dr. Paul Sternberg, Jr.Holland's topic was, "Origin andBehavior of TQ-ST Segment De­flection During Myocardial Is­chemia."Dr. Paul Sternberg, Jr., receivedthe Catherine Dobson Prize for thebest oral presentation by a non­Ph.D. student. His topic was,"Pathophysiology of ExperimentalHyphema Clearance."CalendarWednesday, October 24Reception in conjunction with theAmerican College of SurgeonsMeeting. Pick-Congress Hotel,Grant Park Room, 5:30-7:00 p.m.Tuesday, May 13, 1980Senior Scientific Session and AlumniReceptionWednesday, May 14, 1980Frontiers of Medicine, Alumni As­sociation luncheon business meetingThursday, May 15, 1980Century Club breakfast, Distin­guished Service Award scientificprogram, awards luncheon, eveningreceptionFriday, May 16, 1980Hospital rounds, class parties Continuing Medical EducationSeptember 15-16Neurologic UpdateSeptember 17-22Tutorial on Neoplastic HematologySeptember 26*Frontiers of Medicine, Diagnosisand Treatment of Skin DiseaseSeptember 27-29Aminoclyoside OtotoxicitySeptember 28-29Psychiatry Board PreparationOctober 3-6Postgraduate Course in Obstetrics &GynecologyOctober 8-1 0Molecular Basis of Mutant Hemo­globin DysfunctionOctober 1 2-13Psychiatry and the Law: Searchingfor a ConsensusOctober 17*Frontiers of Medicine, Imaging November 14*Frontiers of Medicine, Evaluationand Management of the InfertileCoupleNovember 16-17Environmental EmergenciesNovember 17-18Assassination, Terrorism, andPolitical ViolenceNovember 26-27Liaison PsychiatryDecember 2-5Conference on Stress ManagementDecember 5*Frontiers of Medicine, BehaviorModification-Biofeedback,Phobias, HypnotherapyDecember 6-8Psychiatry Board Preparation IIFor additional information contactCME Office, (312) 947-5646 or con­tact Frontiers of Medicine Office, *(312) 947-5777.Medicine on the MidwayThe University of ChicagoThe Medical Alumni AssociationThe Pritzker School of Medicine1025 East 57th StreetChicago, Illinois 60637•Address corrections requestedreturned postage guaranteed NON-PROFIT ORG.U.S. POSTAGEPAIDPERMIT NO. 9666CHICAGO, ILL.The Joseph Regenstein LibrarySerial Records Department. Roo�-2221100 East 57th streetChicago, Illinois 00637