Medicine on the Midway Vol. 32 No.1Bulletin of the Medical Alumni Association The University of ChicagoDivision of the Biological Sciences and The Pritzker School of MedicineCover: The student as researcher-many medical students at the University of Chicago, in addition to their rigorous course of study, participate inresearch projects conducted by faculty members, This issue of Medicineon the Midway includes abstracts of twenty-five such investigations reported on at this year's Senior Scientific Session, (Pictured is Dr, DavidSa'� ('77) a first-year resident in medicine, who last year participated inresearch in the laboratory of Dr, Arthur Rubenstein.)Medicine on the MidwayVolume 32, No.1 Summer 1977Bulletin of the Medical Alumni Association of The University of Chicago Division of the Biological Sciences andThe Pritzker School of Medicine.Copyright 1977 by the Medical Alumni AssociationThe University of ChicagoEditor: Jay Flood KistContributing Editor: James S. SweetPhotographers: Mike Shields, John Pontarelli, SandiKronquistMedical Alumni AssociationPresident: Charles P. McCartney ('43)President-Elect: Joseph H. Skom ('52)Vice President: Frank W. Fitch ('53)Secretary: Sumner C. Kraft ('55)Director: Katherine Wolcott WalkerCouncil MembersHoward L. Bresler (,57)Richard H. Evans ('59)Julian J. Rimpila ('66)Randolph W. Seed ('60)Benjamin H. Spargo (,52)Asher J. Finkel (,48) ContentsAccomplishment and Honor: 1977 Medical Alumni 4DayTribute to Dr. Cornelius VermeulenDistinguished Service Award PresentationsFlexner RevisitedDr. Donald TapleyAlumni Elect New OfficersSenior Scientific SessionResidency Assignments for 1977News BriefsIn MemoriamDepartmental NewsAlumni NewsDivisional Alumni NewsThe Editorial Committee is pleased to announcethat Medicine on the Midway's editor, Jay Kist,received the 1977 Beth Fonda Memorial Award inmedical feature writing from the American Medical Writers Association, Chicago Chapter, for anarticle she wrote for The University of Chicago Reports in the Biological Sciences. The article wastitled "Cancer of the Pancreas-Early DiagnosisCombats a Swift Killer." 8101215162930353639423Accomplishment and Honor-1977 Medical Alumni DayAlumni, graduating students and faculty of the Divisionof Biological Sciences and the Pritzker School ofMedicine assembled on campus June 8 for the variedevents comprising the fifth annual Medical Alumni Day.From Acting Dean Robert Uretz's early breakfast welcome to Century Club members in the Quadrangle Club,to the final bang of the gavel as new Medical AlumniAssociation President Charles P. McCartney (,43) calledto a close the evening banquet, it was a day of excitementand honor as outstanding achievements were recognizedand the new physicians welcomed.Distinguished Service AwardsFive distinguished service award recipients presented amorning scientific program and received their awards at afollowing luncheon. (Texts of the presentation speechesbegin on page 10.) Recipients and their topics are:Robert M. McCormack ('43), The Burned PersonPhysiologic and Psychologic Restoration. Dr.McCormack is Professor and Chairman of the Division of Plastic Surgery at the University of RochesterSchool of Medicine and Dentistry and Strong Memorial Hospital in New York.Daniel Porte, Jr. (,S7), What's Wrong with the BetaCell in Diabetes Mellitus? Dr. Porte is Director ofResearch at Veterans Administration Hospital andProfessor of Medicine and Director of the DiabetesCenter at the University of Washington in Seattle.Olaf K. Skinsnes ('47), A Vaccine Potential for Leprosy? Dr. Skinsnes is Professor of Pathology at theUniversity of Hawaii in Honolulu.Joseph H. Skom (,S2), The Doctor's Role as a Citizen.Dr. Skom is Associate Professor of Clinical Medicineat Northwestern University Medical School inChicago.Donald F. Tapley (,S2), Flexner Revisited. Dr. Tapleyis Dean of Columbia University College of Physiciansand Surgeons in New York City.Fifty-year CitationsEleven members of the Class of 1927 attended the awardsluncheon and received SO-year certificates from Dr.Henry Russe (,S7), Associate Vice-President for theMedical Center and Chief of Staff. They are: Paul A.Campbell, Texas; Palmer W. Good, Illinois; George P.Guibor, Illinois; Claude N. Lambert, llIinois; MinnieOboler Perlstein, California; Louis F. Plzak, Sr., Tennessee; John W. Schauer, Ohio; Allan S. Shohet, Illinois; H. Vern Soper, California; George D. Tsoulos,Illinois; and Maurice A. Walker, Kansas.4 Student and Faculty HonorsAt an evening reception and banquet honoring the 1977graduating class, held at the Hyatt Regency Hotel indowntown Chicago, the outstanding achievements ofstudents and faculty members were recognized.Awards to GraduatesGraduation with HonorsStephen John BarenkampRobert Mark DoroghaziRobert Jared DubroffBruce Michael KoeppenSteven Allen Lukes Nancy Josephine OlsenAlan R. RushtonDavid Jerold SalesJohn Archibald Scarlett IIISherwin Allen WaldmanAlpha Omega AlphaStephen John Barenkamp Ronald Gary PearlRobert Mark Doroghazi Peter PompeiDeborah Maxine Friedman Alan R. RushtonStephen Crane Hauser David Jerold SalesBruce Michael Koeppen James Michael SchmittSteven Allen Lukes Joseph SofferJames Arthur Magner Burton F. Vander LaanRobert Paul Marcincin Louis William WuJoseph A. Capps Award, to a senior medical student forproficiency in clinical medicine: Steven Allen Lukes.Catherine L. Dobson Prize for the best oral presentationof research done by a non-Ph.D. student during medicalschool: John W. Karesh.E. Gel/horn Neurophysiology Prize, to a candidate forthe M.D. or Ph.D. in any department of the Universitywho shows outstanding promise in the field ofneurophysiology: Huei-Mei Tsai.Harry Ginsberg Memorial Award, to a medical student inthe Department of Physiology for industry, sincerity andability: Robert Michael Swift.Dr. Harold Lamport Biomedical Research Award for thebest thesis in biomedical research: Robert LaurenceLow.Franklin McLean Medical Student Research Award, to asenior who has performed the most meritorious research:Jack Leslie Weiss.Medical Alumni Prize, for the best oral presentation ofresearch done during medical school: Robert LaurenceLow.John Van Prohaska Award for outstanding potential inteaching, research, and clinical medicine: Bruce MichaelKoeppen.Sandoz Pharmaceutical Award in recognition of outstanding performance in psychiatry: Larry D. Alphs.Mary Roberts Scott Memorial Prize, to a woman medicalstudent for academic excellence: Nancy JosephineOlsen.Nels M. Strandjord Memorial Award, to a senior medicalstudent for outstanding performance in the general fieldof radiology: Scott Ira Fields.Upjohn Award in Medicine, to a senior for outstandingachievement during four years in medical school: JohnArchibald Scarlett III.Awards to FacultyThe Gold Key of the Medical Alumni Association waspresented to Dr. Cornelius W. Vermeulen, (M.D. '37),the Lowell T. Coggeshall Professor of Medical Sciences,Director of Special Projects for the medical center, division and medical school, and Professor of Surgery (Urology). His award was presented by Dr. Richard Landau,Professor of Medicine and Chairman of the Clinical Investigation Committee. (A text of his presentationspeech begins on page 8.)The McClintock Award for outstanding teaching,voted by the graduating class, was presented to Dr.Martha L. Warnock, Associate Professor in the Department of Pathology and Director of the Autopsy Service.Dr. Warnock served her residency in pathology at theUniversity of Chicago, and has been a member of thefaculty since 1965.The Hilger Perry Jenkins Award, given by the graduating seniors for excellence in performance of academicand patient-oriented service, was presented to Dr. DavidSimonowitz (M.D. '70), who has just completed his residency in surgery at the University. This is the secondtime that Dr. Simonowitz received this award, which wasfirst presented to him in 1972.ReunionsMembers of the classes of 1937, 1947, 1952, 1957, and1967 planned reunion activities around Medical Alumniday.The Class of 1937, represented by Dr. and Mrs. E. L.Borkon of Illinois, Dr. and Mrs. William Klein of Washington, D.C., and Dr. and Mrs. Cornelius W. Vermeulenof Illinois, gathered during the evening awards banquet toshare memories and discuss current activities.Forty-one members and spouses of the Class of 1947attended either one or both of two reunion events: aJune9 class dinner at Lawry's, The Prime Rib, and the Medical Alumni Day banquet. Alumni attending were:Joseph R. Barberio, CaliforniaDaniel J. Black, IllinoisLeon A. Carrow, IllinoisKenneth M. Campione, IllinoisGeorge G. Curl, IllinoisHenry De Leeuw, MichiganJohn V. Denko, TexasW. Robert Elghammer, IllinoisRobert G. Frazier, IllinoisJohn T. Grayhack, IllinoisGerald Hill, CaliforniaFrank B. Kelly, J r., IllinoisRichard D. Kershner, California Allan L. Lorincz, IllinoisWilliam L. Lorton, WisconsinDonald F. McBride, IowaAnn M. Pearson, IllinoisIrving H. Rozenfeld, IllinoisCharles J. Ruth, CaliforniaRichard C. Shaw, IllinoisOlaf K. Skinsnes, HawaiiThomas T. Tourlentes, IllinoisForty-three members and spouses of the Class of 1952attended a class dinner at the Ritz-Carlton Hotel on June7. Those alumni attending were:Richard N. Baum, CaliforniaGeorge M. Davies, CaliforniaAlvan R. Feinstein, ConnecticutDavid W. France, Jr., ColoradoRalph V. Ganser, IndianaA. Yale Gerol, WisconsinElsa Gordon, CaliforniaRobert B. Gordon, CaliforniaFred V. Gwyer, IllinoisSeymour L. Halleck, North CarolinaKenneth Hayes, CaliforniaJohn C. Huffer, CaliforniaRaymond N. Kjellberg, MassachusettsA. Gene Lawrence, IllinoisMorris J. Levine, FloridaAndrew E. Lorincz, AlabamaLawrence P. Maillis, IllinoisJames E. McIntosh, MontanaPatrick A. Ragen, WashingtonIrwin Rich, IllinoisJoseph H. Skom, IllinoisBenjamin H. Spargo, IllinoisDonald F. Tapley, New YorkDonald J. Taylor, WisconsinWeldon L. Thomas, IllinoisPeter Wolkonsky, IllinoisThe Cliff Dwellers Club atop Chicago's OrchestraHall was the scene of the Class of 1957 reunion dinner onJune 7. Fourteen alumni and their spouses attended, including:David R. Duffell, IllinoisG. Robert Mason, MarylandRichard H. Moy, IllinoisDaniel Porte,Jr., WashingtonRobin D. Powell, IowaHenry P. Russe, IllinoisFrancis H. Straus II, IllinoisWillard J. Visek, IllinoisSixteen members and spouses of the Class of 1967 attended a class dinner at L'Escargot Restaurant and afollowing reception at the home of class chairman Andrew Griffin on June 7. Alumni attending include:Katherine G. Doede, IllinoisWalter Dorus, Jr., IllinoisEdward Ganz, IllinoisAndrew J. Griffin, IllinoisFrederic R. Kahl, North CarolinaStanford T. Schulman, FloridaMark Siegler, IllinoisNada Logan Stotland, IllinoisSaul Wasserman, California56 234 Dean Joseph Ceithaml presents the Medical Alumni Prize toRobert Low.Dr. Martha Warnock receives the McClintock Award fromgraduate Burton Vander Laan.2 7977 Distinguished Service Award winners: Dr. JosephSkom, Dr. Donald Tapley, Dr. Daniel Porte, ir., Dr. OlafSkinsnes, and Dr. Robert McCormack.3 Dean and Acting Vice President Robert Uretz addressesalumni, faculty, graduates, and families at the banquet.455 Dr. Asher Finkel, past President of the Medical Alumni Association, congratulates graduate Steven Lukes, recipient ofthe Joseph A. Capps Award.6 Dr. Cornelius Vermeulen, recipient of the Gold Key Award.7 Class of 1927: (front row) Dr. Maurice Walker, Dr. GeorgeCuibot, Dr. John Schauer, Dr. Paul Campbell, and Dr. H.Vern Soper. (Back row) Dr. Palmer Good, Dr. MinnieOboler Perlstein, Dr. George Tsoulos, and Dr. Claude Lambert.8 Dr. David Simonowitz receives the Hilger Perry JenkinsAward from graduate Burton Herbstman.7 687911 109 Class of 7952: (seated) Mrs. A. Yale Ceroi, Mrs. Alvan Feinstein, Dr. and Mrs. Arthur Lawrence, and Dr. and Mrs.Robert Cordon. (Standing) Dr. Feinstein, Dr. Cetol, Dr.Richard Baum, and Dr. Kenneth Hayes.10 Class of 7947: (front row) Dr. Allan Lorincz, Dr. Cerald Hill,Dr. John Denko, Dr. William Lorton, Dr. Ann Pearson, Dr.Irving Rozenfeld, and Dr. Joseph Barberio. (Back row) Dr.Thomas Tourlentes, Dr. Henry De Leeuw, Dr. Frank Kelly,[t ., Dr. Richard Shaw, Dr. Charles Ruth, Dr. Robert C.Frazier, and Dr. Donald McBride.11 Class of 1957: (from left) Mrs. Daniel Porte and Dr. Porte,Dr. and Mrs. Richard Moy, Mrs. David Duffell and Dr. Duffell, Dr. and Mrs. Frances Straus II, Dr. C. Robert Mason,Mrs. Henry Russe and Dr. Russe, Dr. Willard visek, Mrs.Robin Powell and Dr. Powell.Tribute to Dr. Cornelius VermeulenI have heard authoritatively that Dr. Vermeulen's firstpaid job was that of a grave digger. This was, of course,before he received his M. D. from the University ofChicago in 1937. There will be those who will remark thatgrave digging laid the ground-work for his successfulcareer as a medical plumber, a urologist. But I wouldn'tsay that. I shall pun, however, to say that he continued acareer digging-digging for the facts both as a researcherand a unique medical administrator.He completed his graduate training, internship, andresidency here in Dallas B. Phemister's great Department of Surgery. In the 1930s and early 1940s it was arare University of Chicago surgical department residentwho failed to become a professor of surgery someplacerather soon. Phemister, Dragstedt, Huggins and their associates were great teachers, in part because they knewhow to select exceptional students. Vermeulen was chosen. His choice of urology as a subspecialty brought himunder the guidance of Charles Huggins, who was almost8 singlehandedly guiding the surgical specialty of urologyinto the scientific era of the twentieth century.As a urology resident Vermeulen had a patient whoappeared with the intractable pain and almost total disability of prostatic cancer with metastases to the bones ofthe spine and pelvis. Dr. Huggins' studies with dogs hadsuggested that some prostatic tumors were dependent onthe testicular male hormone. Accordingly, castration wassuggested to the patient, who became the first to be sotreated for advanced prostatic cancer. After the operation, improvement was spectacular and the patientwalked out of the hospital. He died twelve years later ofheart disease.Vermeulen's powerful, almost evangelistic descriptionof the drama of this great medical discovery, while hewaved X-ray films in his long arms, held a normally passive medical conference audience spellbound. To listenwas an inspirational event. This presentation served as aremarkable revelation of the true emotional constitutionof this usually dispassionate-appearing medical scientistand teacher, for Dr. Vermeulen feels and lovesdeeply-his family, his patients, his students, his colleagues and his University.At the completion of his training Vermeulen joined thefaculty of the University of Illinois as associate professorof surgery. In 1953 he returned here as professor ofsurgery and head of the urology section. He was determined to continue the tradition of research and training, so determined that he was even willing to borrow anidea from the Department of Medicine-a system of rotation on and off major teaching and clinical responsibilitiesso that the urologists would have sufficient continuoustime to do productive research.His own research interest was directed toward gainingan understanding of the factors which cause urinary calcium stone formation and those which inhibit their formation. He was among the first to emphasize the importanceof the super-saturated state of urine with respect to theionic constituents of the stones. He was the first to pointout that these stones formed at the renal papillary tips.He also contributed substantially to the now-confirmedconcept that normal urine contains a small molecularchemical which maintains the solubility of the constituents of stones.As head of the urology section he supervised the training of Ed Lyons, Bill Gill, Warren Chapman, GeorgeMiller, John Sawyer, Duncan Govan, Tom Borden,Floyd Fried, James Roberts, John Sommer, BirdwellFinlaysen, David Proctor, and Marvin Morrison. Ofthese thirteen, ten have full-time academic posts at theUniversity of Chicago or elsewhere-in keeping with theUniversity's aim to be a teacher of teachers.When Dean Coggeshall retired, Vermeulen found himself on the faculty committee elected to advise PresidentKimpton on the appointment of a new dean. The eightperson committee elected him chairman. It was a committee with a difficult challenge, for at this time the basicscience faculty was seriously considering breaking theDivision of Biological Sciences into two portions, andthis committee became the focal point for such a serious,controversial proposal. Vermeulen's handling of this difficult political situation-which amounted to holding theDivision together during the dean selection process-was so impressive that President Kimpton gave serious consideration to appointing him dean.Five years later when Dr. Jacobson became dean, hepersuaded Vermeulen to become the associate dean forclinical affairs. I n the eight years he served in the Dean'soffice, the principal crisis he faced was not political butfinancial, and similar to that of other medical institutionswhich seemed to be able to use money faster than it camein. He was a determined digger for facts in a hospitaladministration whose main aim had not been fiscalsolvency but the provision of teaching and researchfacilities for a growing and demanding faculty. Hisanalysis of the facts and subsequent proposals probablysaved our school as a leading private medical institution.President John Wilson has asked me to read the following statement concerning Vermeulen's accomplishmentsin the Dean's office. "In addition to those virtues whichhave been recognized in Dr. Vermeulen's exceptionalservices as a faculty member in the Division of BiologicalSciences and the Pritzker School of Medicine, it is mypleasure to call attention to others of a broader scope.From the point of view of the University as a whole, theproblem of establishing financial integrity and stability inthe Biological Sciences Division and the Pritzker Schoolof Medicine was one of the several crises during the earlyyears of the 1970s."As is the case with most problems in the biomedicalarea, it was not a minor one, and in the resolution of thisvaried and complex difficulty no one was of more help toan embattled dean and provost than Dr. Vermeulen. Hisintimate knowledge of the internal operation of both theDivision and the school, his absolute personal integrity,and his judicious sense of balance between the parochialinterests that reside on the west side of Ellis A venue, incontrast to the needs of the University generally, combined to make his advice an invaluable resource."It is also quite fitting that his distinguished services tothe University should be recognized at the same time thathe is receiving the Gold Key of the Medical Alumni Association. At Mr. Wilson's request I am privileged toannounce for the first time that effective July I st of thisyear, Dr. Vermeulen became the Lowell T. CoggeshallProfessor of Medical Sciences at the University.-Dr. Richard L. Landau9Distinguished Service Award PresentationsDr. Robert McCormackIn awarding the Distinguished Service Award to Dr.Robert M. McCormack, the University of Chicago recognizes one of the great pioneers and leaders in the important field of plastic and reconstructive surgery. Dr.McCormack's contributions place him at the forefront ofhis specialty in all three categories of the academic triad.His numerous research publications have led to advances of knowledge, particularly in matters related todiseases of the hand and to burns. He has been widelyrecognized as a superb clinical surgeon, and this recognition was formalized by his designation as the clinician ofthe year in 1975 by the American Association of PlasticSurgery. As a teacher, he has served the University ofRochester faithfully and well for many years, and hasrecently received national recognition by being namedthe 1976 Visiting Professor for the Educational Foundation of the American Society of Plastic and Reconstructive Surgery.Dr. McCormack received his undergraduate degreefrom Swarthmore College, where he excelled in footballas well as in academic pursuits. He received his M.D.degree from the University of Chicago School ofMedicine in 1943. Following an internship and one yearof residency at the University of Rochester, he enteredthe army and began to develop his life-long interest inhand surgery. He was chief of the Hand Surgery Serviceat the William Beaumont Army Hospital from 1945 -1947. After completing his residency at the University ofRochester in 1949, he joined the faculty of that medicalschool. He rose rapidly to the rank of professor in 1957and was named vice-chairman of the Department ofSurgery in 1968.In addition to his clinical and research contributionsand important teaching activities at the University ofRochester, Dr. McCormack has been a recognizedleader in surgery both nationally and internationally.Among his 32 society memberships are included fellowship in the American Surgical Association, and electionto Alpha Omega Alpha. He has served as an officer of allof the important societies of his specialty, including thepresidency of the American Society of Surgery of theHand in 1964, chairman of the Plastic Surgery ResearchCouncil in 1966, chairman of the American Board ofPlastic Surgery in 1968, president of the American Association of Plastic Surgeons in 1968, chairman of theAmerican College of Surgeons Council for Plastic andMaxillofacial Surgery in 1963, and president of the American Burn Association in 1971.He has undertaken broader responsibilities in medicaleducation and served as the vice-president of the Councilof Medical Specialty Societies in 1972 after many years ofleadership in this organization. He has served on theResidency Review Committee for Plastic Surgery and isthe associate editor of four major journals.Dr. McCormack has received many honors and10 awards, including the Award of Merit from the RochesterAcademy of Medicine, and has given a number of important lectureships. It is with pride that the University ofChicago recognizes Dr. Robert McCormack as a trueleader in American surgery by the presentation of thisDistinguished Service Award.-Dr. David SkinnerDr. Daniel PorteIt is a great pleasure for me to introduce Dr. DanielPorte, J r., one of the recipients of a Distinguished Service Award. Dan was born in New York City in 1931. Hereceived his B.A. in 1953 from Brown University.Thereafter, he came to the University of Chicago for hismedical training and was awarded his M.D. degree withhonors in 1957. Following a year of internship in SanFrancisco he was appointed a United States PublicHealth Service fellow at the Cardiovascular ResearchInstitute of the University of California. He completedhis service in the U.S. Navy and his residency by 1963.In 1963 Dr. Robert Williams, who has been so successful over the years in attracting the best young people inthe country to join his diabetes-endocrinology trainingprogram, recruited Dan to Washington University inSeattle. There Dan blossomed and rapidly progressed upthe academic ladder from an advanced research fellow ofthe American Heart Association to assistant professor,associate professor and finally full professor of medicinein 1973. In addition, he was appointed associate chief ofstaff for research at the Seattle Veterans AdministrationHospital, and chief, Division of Endocrinology andMetabolism at the same institution in 1975. This yearDan assumed the directorship of the DiabetesEndocrinology Research Center at the University ofWashington.Dan has received a number of important awards andhonors, including the University of Chicago MedicalHonor Scholarship, a NIH Career Development Award,and the Eli Lilly Award of the American Diabetes Association in 1970. In addition, he is a member of manynational research and professional societies, includingthe American Society of Clinical Investigation, the Association of American Physicians, the American Physiological Society, the Endocrine Society and the AmericanDiabetes Association.This year, Dan was elected chairman of the MedicalAdvisory Board of the Juvenile Diabetes Foundation, anappointment which indicates the high esteem in which heis regarded by both the scientific community and the laymembers of the organization, who are mainly parents ofdiabetic children.Since 1961, Dan has published over 100 scientific manuscripts. In the short time available this afternoon, I canonly touch on the highlights of his very substantial scientific contributions. The first field that I would like to mention is that of insulin secretion.In 1966 Dan and his coworkers initiated a series ofclassical experiments which described the inhibitory effect of epinephrine and norepinephrine on insulin releasein man. In subsequent years Dan has been at the forefront of research aimed at elucidating the role of the central and peripheral nervous systems in controlling hormone secretion from the islets of Langerhans.In addition, he has integrated this work with incisiveand elegant experiments aimed at defining the secretorydefect in pancreatic beta cells which underlies the diabetic syndrome. A hallmark of his research has been thecare with which he has designed and carried out studiesin healthy controls and patients, and the meticulous manner in which he has analyzed his findings and drawn appropriate conclusions.This then is the factual background. In itself, it wouldbe sufficient to commend Dan for this award. However,those of you who have had the pleasure of knowing Danas a friend and colleague know, as I do, that it only describes one aspect of his accomplishments. The otherconcerns his warm personality, readiness to be helpful,generosity with ideas, and leadership qualities. For sometime I have mentioned how impressed I have been by thespirit of unity among scientists working on diabetesrelated research. Dan is one of those who nurtures thisatmosphere and provides the basis for its existence.For all these reasons, it gives me special pleasure topresent a Distinguished Service Award of the MedicalAlumni Association to Dr. Daniel Porte, J r., and to wishhim continued success and happiness in the years ahead.-Dr. Arthur RubensteinDr. Olaf SkinsnesThe man that I am honored to present is a humanitarianfirst and foremost. Olaf Kristian Skinsnes was born inChina, son of a missionary physician, attended St. Olaf'sCollege, and joined the University of Chicago as a student in 1940. He obtained a Master's Degree in 1946 andM.D. and Ph.D. degrees in 1947 from this institution.He remained at the University as an assistant inpathology until 1946, when he took an internship at NewYork Hospital. From there he went to the University ofHong Kong, where he remained as a senior lecturer until1959, then returned to his alma mater as professor ofpathology.To the younger members of the Pathology Departmentat the University of Chicago and to many of our medicalstudents, these were the years when we learned to appreciate Dr. Skinsnes as a teacher, investigator andfriend. His life-long interest in Oriental culture and hisscientific interests in the medical and social aspects ofinfectious diseases added a new dimension to the teaching of this medical school, one achieved by few, in any,other academic institutions. It was here that he began towrite the multi-volume Chinese Medical History.It may be said that the Chinese proverb, "He who isfor one day my teacher is my father for life," best appliesto Dr. Skinsnes. But his achievements as a teacher andtrainer are only a small measure of the man we are honoring. For many years, he has been a leader in the field ofleprosy research, as we witnessed this morning in hislecture. Research on leprosy, however, does not confineitself to a search for the causative agent-which his countryman, Armauer Hansen, had allegedly described first in1874-nor to the development of vaccine. To Dr. Skinsnes, research in leprosy is social medicine in the bestsense of this misused term, whether it is manifested in theestablishment of.a leprosorium near Hong Kong or by themany humanitarian services he has rendered to patientswith leprosy throughout the world.In presenting to Dr. Skinsnes the Distinguished Service Award, we honor the scholarship and humanitarianspirit that he has represented to us for so long.-Dr. Werner KirstenDr. Joseph SkomIt is a real pleasure today to share with all of you thistraditional and still exciting event in which the Universityof Chicago Medical Alumni Association honors some ofits members, and a pleasurable task to introduce one ofour alumni, Joseph Skom, who migrated to the University of Chicago from the little village of Aurora after threeyears of military service, graduating with honors.He then went on to get his S.B., an M.S. in Physiologywith honors, and an M.D. with honors, all at the University of Chicago. Joe then interned at Johns Hopkins andreturned to the University of Chicago where he completed his residency and a subsequent fellowship in public health.He remained on the faculty for the next few years andthen went into practice with a distinguished group ofinternists on the north side, where he has remained to thepresent time. As a member of the faculty of Northwestern University he has continued research begun at theUniversity of Chicago. Among his many honors, JoeSkom is currently president of the Illinois State MedicalSociety.Although he is certainly well known for his scientificworks spanning the fields of experimental hypertension,renin and antirenin, immunology, endocrine disorders,and his very important work in drug abuse, Joe is perhapsbest known for a non-scientific event in his life.One morning, one of the adventurous Skom childrendecided to broaden her horizons, and an object near athand provided the opportunity to do just that. The littleSkom climbed higher, higher, and ever higher, and finallyarrived somewhere near the top of a rather tall radiotower in their neighborhood. This event received widecoverage, even on national television, which continuedfor several weeks thereafter. The notoriety of that eventhas subsequently subsided and one rarely hears of itthese days.Perhaps one of the most pleasant events related to theUniversity of Chicago in the life ofJ oe and Edie Skom isthe fact that this daughter is now a sophomore at thePritzker School of Medicine. Of particular poignancy isthe fact that Harriett's apartment when she first came tothe University as a freshman medical student was the11exact place in which Joe and Edie Skom had started theirmarried life at the University of Chicago.Joe, it is a distinct pleasure to present to you this Distinguished Service A ward.-Dr. Henry RusseDr. Donald F. TapleyDonald F. Tapley was born in Woodstock, Nova Scotia,went to undergraduate school at Acadia University, andgraduated from the University of Chicago School ofMedicine in 1952. He then ventured east to begin his longaffiliation with the Columbia University College ofPhysicians and Surgeons (P & S), starting as an intern atPresbyterian Hospital in July, 1952. Regrettably, I didnot know Dr. Tapley during his years at the University ofChicago, but I did share the next two years on the P & Shousestaff.He spent these two years under the tutelage of Dr.Robert F. Loeb, whose austere high standards as chairman of medicine surely left an imprint on Tapley andhelped shape his career, as they did for so many otheryoung physicians.Next, Tapley dove into rather basic medical-in factendocrinologic-research, spending a year withLehninger at Johns Hopkins and a second year at Oxford. During this time he studied fundamental aspects ofthyroid hormone action, and found that thyroxine induced swelling of mitochondria and the release ofpyridine nucelotides from mitochondria. This responsepreceded and perhaps caused the subsequent uncouplingof oxidative phosphorylation.He returned to Columbia in 1956 as an assistant professor and continued as an endocrinologist-teacherresearcher.The focal point of his research was a search for thefundamental effects of thyroxine on mitochondrial func- tion. In a series of studies extending over eight years,performed in collaboration with M. P. Primack and J. L.Buchanan, Dr. Tapley found that triiodothyronine, givenin vivo, increased mitochondrial protein synthesis inthree hours. Thyroxine added to mitochondria in vitroalso promptly induced new protein synthesis. This response was supported by an A TP generating system, anddid not require prior conversion of thyroxine totriiodothyronine. The protein synthetic response couldbe dissociated from the action of thyroxine on oxygenconsumption by puromycin.During this time, Tapley gradually developed a reputation among students and house officers as an exceptionaladviser, confidant, and teacher. Perhaps his own interestshifted gradually toward medical education.In 1970, with his appointment as Associate Dean forFaculty Affairs, this role became official, and in 1973 hebecame the Dean.Donald is credited with leading a renaissance at Columbia. These very words were used at P & S a fewweeks ago, so it can be said with certainty that this is howhis own faculty views his accomplishments in recentyears. Perhaps renaissance may not be the perfect word,since P & S has never been anywhere but at the top inmedical education. However, under his leadership therehas been a rebirth of confidence in the school, sweepingchanges in the curriculum, the recent development of amagnificent new library and instructional facility, and development of a sense of progress which has altogethergiven P & S a new air.His accomplishments are large at barely the midpointof his career. The University of Chicago believes that itteaches teachers. Donald is certainly a prime example ofthe best the University can do.-Dr. Leslie De GrootFlexner RevisitedDonald F . TapleyAbraham Flexner is widely regarded as one of the greatheroes of American medicine. Near the turn of the century, he found an abundance of poor schools with grosslyinadequate standards-schools whose only criteria forentry were the abilities to read, write and pay the bills.He found also that unfortunates who needed the help ofdoctors were more likely to be cared for by "charlatans"than by physicians adequately grounded in scientificmedicine. He enumerated the virtues and analyzed thedeficiencies of the then-existing institutions of medicaleducation in the United States, rated each school, andproposed the measures which would raise Americanmedical education to the level of that of Germany, England and France.These steps included the elimination of inferior schoolsand the universal adoption of the requirement that medical schools offer a graded basic science curriculum, followed by clinical clerkships conducted in the wards of a12 hospital. In addition, he stressed the importance of fulltime faculty, arguing that principles of medicine shouldbe taught by professors, and he insisted that research laboratories be linked with clinical facilities. Three strongconvictions lay behind Flexners advocacy of these measures: a belief in the importance of the university; thepostulate that medical education could thrive only in anenvironment in which biomedical research was performed at the highest level; and a deep sense that institutions of medical education should be protected frominvolvement in health care delivery.It is of interest that Flexner found the University ofChicago "neither fish nor flesh nor good red herring"because its medical school was divided. Genuine preclinical university instruction was offered on the campusitself; clinical instruction conducted by local professionals took place in a remote part of the city. As youknow, Flexner was largely responsible for changing theUniversity of Chicago medical school into "good redherring" by insisting that clinical instruction be broughtto the University campus.The changes in American medicine with which Flexneris almost universally credited began considerably earlierthan his time. The rise of German scientific medicine inthe last half of the 19th century, the development ofgraduate university education in the United States, theformation of the Johns Hopkins University medicalschool, the efforts of the Association of American Medical Colleges and even those of the American MedicalAssociation were the main sources of the recommendations which Flexner incorporated in his report.Thus, it may be more correct to see Flexner not somuch as the initiator of broad and sweeping reform, butrather as the catalyst who with the greatest energy andcourage applied standards advanced by others, and recommended measures conceived by others in order to im-prove American medical education. Sociologist RobertMerton has noted that Flexner's report, which carriedthe imprimatur of the Carnegie Foundation for the Advancement of Teaching, "largely closed the gap betweenprivate knowledge of departures from accepted standardsand public acceptance of those standards." His ideasmay have been less original than is commonly assumed,but the changes recommended by Flexner have come todominate American medical education.The changes to which Flexner's reforms led have had at least six consequences:• The quality of American medical education has improved greatly in comparison with that which was provided in the era of the diploma mills.• Medical knowledge and capabilities have expandedenormously. Because of this growth, the period sinceWorld War II can be compared in scientific productivitywith the "Golden Era" of German medicine during thelatter half of the 19th century.• A many-stranded bond of interdependence has developed between teaching and research in medical education. The sum of biomedical knowledge has long exceeded anyone individual's capability for mastery.Hence, the medical school's function has become that ofinstilling in its graduates a knowledge of the broad outlines of the many relevant disciplines, a critical competence, and a disposition to lifelong self-education.• The quality of medical care within those hospitalsclosely affiliated with our medical school has improveddramatically. The improvement is a direct consequenceof more extensive biomedical research and more rigorouseducational procedures.• There has been an important change in the expectations of the American public which is related to the emphasis Flexner placed on research. Since World War II,we have indeed achieved a large number of authenticadvances in health care, and an eager public, to whomthese marvels of modem medicine have been incessantlylauded, has been waiting for the universal application ofmethods to make everyone healthy, happy and creative.These visions, at least in their exaggerated form, arenot the creation of responsible physician-scientists. Butas the public has come to perceive a failure to deliverboth the authentic and the more fanciful promises ofmodem medicine, and as the deficiencies of health caredelivery remain largely uncorrected, disillusionment hasset in. And it is on the medical schools that the public,through its elected representatives and through the press,places a large part of the responsibility for these disappointments.• Finally, in following what they construed as the implications of the Flexnerian model, most medical schoolshave remained comparatively isolated from social concerns, and lack the means to effectively enter into publicdebate. In particular, medical schools have failed to takethe lead in studying the problem of health care deliveryand developing recommendations as to how an improvedsystem should be organized.Society is now telling us that we have responsibilitiesas physicians as well as professors. The voices are becoming more strident. But it is unfair that society shouldblame the medical schools for the maldistribution ofphysicians; it is unfair that society should blame the medical schools for training too many specialists; it is unfairthat society should blame the medical schools for thedeteriorating care of the population which surrounds us,particularly in the urban ghettos.Or is it?We do have more influence on the career choices of ourstudents than we care to admit. We do have more influence (if not control) over the graduate training pro-13grams in our hospitals than we willingly acknowledge.And we do bear a major responsibility, because of ourlong-standing holier-than-thou attitudes towards the"LMD's" (local medical doctors) in our communities,for the disappearance of the practicing physicians in ourimmediate surroundings.I n one way it is fortunate that the health care deliverysystem has become so chaotic. The mess is so great andthe problem so complex that it now can be solved only bya massive research and development effort. And researchis what both we and the University consider ourbailiwick. Without taking on additional corporate responsibility for patient care, we must assume leadershipin the development of new models of health care, modelswhich result in the effective delivery of care to hundredsof thousands of men and women in the underservedurban and rural areas. This would correct the problems ofgeographic and specialty distribution without, societysays, increasing the cost. I am sure that Flexner, were hehere, would consider this a problem worthy of the talentswhich University medical schools can bring to bear uponit.At the Columbia University College of Physicians andSurgeons, we have begun to approach the problem withthe establishment of a "Center for Community HealthSystems." This research center enlists the substantialand varied resources of the university jointly with thefaculty of medicine and its affiliated teaching hospitals ina systematic attack on problems in organizing and delivering health care, especially in urban areas.The problem we face is immense-our affiliated hospitals in New York City alone serve a population greaterthan that of the city of Boston. And outside our hospitalswe serve this population badly. We do not intend that theCenter itself will assume the responsibility for providingmedical care. Rather, it is intended to serve as a researchand development arm and to design and evaluate newpatterns of health care delivery. We have begun to makeinroads on the problem, but the task is formidable.It clearly is urgent that we rethink the traditional division oflabor within the health professions. We have beentoo slow in sharing our professional responsibilities withour colleagues. Society is now telling us that it cannotand will not support the use of highly trained physiciansto do tasks which can be performed by other professionals whose training is less costly. But we can successfully transfer the responsibility for performing suchtasks only if we succeed in changing our educationalmethods so that the physician, the nurse and the alliedhealth professional are trained in a new and appropriatelycoordinated setting. This, too, is a research and educational challenge worthy of university medical schools.The Flexnerian legacy, in which most medical schoolsremain comparatively isolated from social concerns, hasleft us with few effective ways of entering into publicdebate, or of influencing public policy, or even of projecting our true aspirations and image.Describing this year's Columbia graduation, the NewYork Times reported:"One of the honorary-degree recipients kissed theUniversity president gratefully, a bearded philosophernoted for a historical study of skepticism chewed gum14 throughout the long citation of his achievements, andstudents mockingly chanted, 'socialized medicine,socialized medicine' as the dean of medicine crossed theplatform. The dean grinned at the students."Is it mockery when undergraduate students confront uswith a call for "socialized medicine"? The New YorkTimes thinks so. There is indeed something wrong withour image when society, as reflected in a newspaper ofthis caliber, does not realize that academic faculties suchas those at Columbia University and the University ofChicago have been practicing a form of "socializedmedicine" for half a century, and that these sameacademic faculties, far from opposing the development ofa National Health Plan, are actively involved in the evolution of that scheme, concerned that it be as effectiveand as rational as possible.A major legacy of the Flexner era has been a remarkable cadre of physician-scientists. Nothing must be doneto weaken a process which has had such results. Butsociety now is telling us that this is not enough. It istelling us that we must reform our educational processesin order to develop over the next quarter century anequally remarkable cadre of physician-citizens. If suchphysician-citizens are to emerge from our schools, medical students must be involved with disciplines relevant tothe improvement of our health care system--disciplinessuch as the social and behavioral sciences, economictheory, political theory, planning and administration.At the undergraduate level, I fear that (as with mostareas of medicine) we can but expose them to the rudiments and provide them with outstanding role models;postgraduate training programs must provide the refinement. We have been eminently successful in developingthe physician-scientist; I see no reason why we cannot beequally successful in developing a similarly remarkablecadre of physician-citizens. It may take another quartercentury to undo the damage of the past, but the damagemust be undone. And the spearhead for any change in themedical system must be the physician.We must rethink the Flexnerian model of medical education. Both biomedical research and greater social responsibility must be provided for. Universities arenotoriously ineffectual whenever they attempt to dealwith the societal problems which surround them. Thechallenge is how to remain deeply rooted in the University tradition while responding effectively to the needs ofsociety.If Flexner were here today, he would be gratified bymost of the changes that followed upon the recommendations published in his report. However, I think hewould be surprised at some of the unfortunate consequences of his legacy-and I venture that he would judgethe assumption of leadership by a medical school (even aUniversity medical school) in solving these problems tobe a worthy effort.Or. Donald F. Tapley (M.D. '52) is Dean of Columbia University College of Physicians and Surgeons in New YorkCity. He presented this speech at the Scientific Program bydistinguished Service Award Recipients during MedicalAlumni Day, June 8.Alumni Elect New OfficersBeginning their terms as officers of the Medical AlumniAssociation for 1977-78 are:President, Dr. Charles P. McCartney (,43), clinicalprofessor of obstetrics and gynecology at the Universityof Illinois; president-elect, Dr. Joseph H. Skom (,52),associate professor of clinical medicine at NorthwesternUniversity Medical School; vice president, Dr. FrankW. Fitch (,53), the Albert D. Lasker professor of pathology at the University of Chicago; and secretary, Dr.Sumner C. Kraft ('55), professor of medicine at the University of Chicago.Dr. Julian J. Rimpila ('66), who has a private practicein gastroenterology in Oak Lawn, Illinois, was elected amember of the Alumni Council for 1977-80. Dr. Earl A.Hathaway (,46), who was also elected to the Council,died suddenly on June 12 (see box).* * * * *Dr. Charles McCartney assumes the presidency of theMedical Alumni Association at a very exciting time-the50th anniversary celebration of the medical school. Hiscurrent objective as president is to help observe the anniversary in an appropriate manner. He remembers hisown student years at the medical school, and recalls thathe and fellow students "felt we were going to the bestmedical school in the world."Dr. McCartney received both his S.B. and M.D. degrees from the University, and served his internship andresidency here. He joined the faculty of the Departmentof Obstetrics and Gynecology in 1950 as an Instructor,becoming Assistant Professor in 1952, Associate Professor in 1957, Secretary of the department from 1958--67,and the Mary Campau Ryerson Professor of Obstetrics and Gynecology from 1967-70. He is presently ClinicalProfessor of Obstetrics and Gynecology at the University of Illinois Abraham Lincoln School of Medicine,Professor Emeritus of Obstetrics and Gynecology atRush Medical College, and a member of the Clinical Associate Staff at Chicago Lying-in Hospital.A former president (1973-74) of the Chicago MedicalSociety, Dr. McCartney has been active in numerousprofessional societies, including the American Association for the Advancement of Science, AmericanGynecological Society, Society for Gynecologic Investigation, American College of Obstetricians andGynecologists, Chicago Gynecological Society (secretary, 1960-63; president, 1967; advisory council, 1968),and the Illinois State Medical Society. He is a member ofAlpha Omega Alpha.He has served on several committees, including termsas chairman of the Illinois Section of the American College of Obstetricians and Gynecologists, of the ChicagoMedical Society's Advisory Committee on Maternal andChild Health, of the Illinois State Medical Society's Reference Committee on Publications and Scientific Services, and of the Obstetric Planning Committee of theCook County Committee of Joint Maternal Welfare.At the University of Chicago, he has been chairman ofthe Credential-Liaison Committee and the Ford Foundation Fellowship Committee, and a member of the Committee for Clinical Investigation and the Committee onthe Tumor Registry and Medical Records.Dr. McCartney is the author of several scientific papers, articles and books on hypertensive disorders inpregnancy.In MemoriamEarl A. Hathaway, 1922-1977Dr. Earl A. Hathaway, former alumnus and faculty member, died inElmhurst, Illinois on June 12. He was elected to serve as a memberof the Council of the Medical Alumni Association for a 1977-80term.Dr. Hathaway maintained a private practice of primary care inElmhurst since 1954, and was affiliated with Memorial Hospital.He received his S.B. from the University of Chicago in 1944, andhis M.D. in 1946. In 1950 he joined the faculty of the University'sDepartment of Medicine as an assistant in medicine, and in 1952 hebecame research associate/instructor. From 1951-53, he was also anassociate physician with the Health Division at Argonne NationalLaboratory.Dr. Hathaway is survived by his wife, Betty; four children,Stephen, Michael, Sarah, and Emily; and two grandchildren. Hisbrother, Ralph Hathaway, is a biologist at the University of Utah.Memorial contributions may be made to the Earl Hathaway Remembrance Fund at Memorial Hospital, Schiller and A von, Elmhurst, Illinois, 60126.15Larry A/phsRobert DoroghaziLinda HugheyJohn Karesh16 Robert DempseyStephen HauserDavid Kape/anskiBruce Koeppen Senior Scientific SessionTwenty-five senior medical students (Class of '77) presented reports on their research projects at the 31 st Annual Senior Scientific Session on May 25. Chairmen of thefour-part program were Dr. Arthur Herbst, Dr. HenryRusse, Dr. Harry Schoenberg, and Dean Robert Uretz.Members of the Committee on Arrangements were Dr.Clifford Gurney, Dr. David Skinner, Hewson Swift, andDr. Martha Warnock, chairman.Evidence for Central Adrenergic Regulation ofthe Light-Mediated Suppression of Serotonin:Acetyl Coenzyme A: N-Acetyltransferase in theRat PinealLarry AlpsSponsor: Dr. Alfred HellerDiscussant: Philip C. Hoffmann, Ph.D.Rat pineal serotonin: acetyl coenzyme A: N-acetyltransferase activity is normally elevated during periods ofdarkness and depressed during periods of light. The reduction of induced levels of N -acetyltransferase activityby light has been demonstrated to have a half-time ofabout three minutes. In contrast, when protein synthesisis blocked pharmacologically, the half-time of the enzyme fall is about sixty minutes. This suggests that exposure of animals to light results in an active inhibition ofenzyme activity. Information regarding environmentallighting reaches the pineal via a complex neuronal pathway.Experiments were designed to pharmacologicallyblock neurotransmission along this pathway and so blocklight suppression of N -acetyltransferase activity. Alphablocking agents such as phenoxybenzamine and phentolamine successfully blocked the decrease in pinealN -acetyltransferase activity following exposure of animals to light for ten minutes. When animals were administered the alpha agonists methoxamine and clonidineintraperitoneally, falls in enzyme activity occurredmimicking those produced by light. In contrast, intraperitoneal injections of norepinephrine and phenylephrine did not affect levels of enzyme activity. However,norepinephrine did cause a fall in activity when it wasinjected intraventricularly. These results suggest that analpha adrenergic receptor mediates light suppression ofenzyme activity. Also, since norepinephrine only produces a fall when the blood-brain barrier is bypassed withintraventricular injections, it is further suggested that thisreceptor is located within the central nervous system.These data demonstrate that stimulation of a receptor sitewithin the central nervous system can modulate a discrete biochemical event in a peripherally innervated endorgan.Enzyme Efflux from Skeletal Muscle: Reductionby DiethylstilbestrolRobert DempseySponsor: Dr. Louis CohenDiscussant: Dr. Alfred HellerIt has previously been shown that oral diethylstilbestrol(DES) lowers the high serum enzyme levels attributed tomuscle cell injury in Duchenne's muscular dystrophy(DMD). The present studies were undertaken to determine if this effect of DES could be attributed to areduction in the efflux of enzymes from isolated mouseskeletal muscle, and to develop a model system for therational assessment of other potentially useful compounds. Thirty-four male mice were used. Half receiveddaily subcutaneous injections of ten J.Lg diethylstilbestrol-diphosphate (DES-DP) in saline for up tothree weeks; the other half received daily saline injections. The left gastrocnemius was isolated from control and treated mice, and placed in separate incubationsolutions at 37°C. The efflux of creatine phosphokinase(CPK) and lactate dehydrogenase (LDH) from each wascompared over a four- to five-hour period.In 15/18 studies, there was a reduction in efflux of bothenzymes from muscles isolated from DES-DP treatedmice. The greatest effect was noted during the secondhour, when the mean efflux of each enzyme was reducedby approximately thirty percent. Minor differences inmuscle weight, water content and enzyme activities didnot explain the reduced efflux. Autoradiographic studiesusing H3DES showed intracytoplasmic accumulationwithin the mouse skeletal muscle. The results suggestthat DES or one of its metabolites localized in skeletalmuscle, and reduced enzyme egress by either reducingmuscle cell permeability or enhancing intracytoplasmicstability of the enzymes.This is the first compound given in vivo which has beenshown to reduce the spontaneous enzyme efflux fromisolated skeletal muscle. It remains to be established thata similar effect accounts for the serum enzyme reductionobserved when DES is administered to persons withDMD. Nevertheless, the use of this model has made itpossible to identify other agents that suppress the enzyme leakage, and with molecular modeling is providinginsight into the molecular characteristics which influenceenzyme leakage.The QT Interval in Myocardial InfarctionRobert DoroghaziSponsor: Dr. Rory ChildersDiscussant: Dr. Morton ArnsdorfThe QT interval of the electrocardiogram represents thetime required for ventricular activation and recovery.The corrected QT duration and depth of T wave inversion were measured in sequential EKGs in 71 enzymeproven myocardial infarctions seen at Billings Hospitalfrom 1974 to 1976. Ralph KunclSteven LukesAnthony MeyerNancy Olsen Robert LowRobert MarcincinGeorge Moll, Jr.Ronald Pearl17The results show that both the QT interval and the Twave undergo an orderly sequence of change in the daysfollowing myocardial infarction and that the time coursesof these changes are similar. QT prolongation is maximalin all infarctions on the second day. T wave inversion ismaximal at two and three days post-infarction in nontransmural and transmural infarctions respectively.These changes were more marked in non-transmural infarction. Regardless of the magnitude of QT prolongation, all observed QT intervals had returned to normal bythe sixth day post-infarction.The data suggest that QT prolongation later than sixdays following myocardial infarction is not intrinsic to theinitial event and another cause should be sought.The dangerous period of" electrical instability" following acute myocardial infarction has hitherto beenexamined only in terms of the statistical occurrence oflife-threatening rhythm disorders. This study provides ayardstick by which it can be measured in the clinicalEKG.Alkaline Phosphatase in lymph and Serum afterBile Duct ligationStephen C. HauserSponsor: Dr. Alfred L. BakerDiscussant: Dr. Martha L. WarnockPrevious studies have demonstrated that bile duct ligation produces a marked increase in alkaline phosphatase(A P) in serum and that this increase is dependent on newprotein synthesis by the liver. The purpose of this investigation was to determine whether hepatic AP entersthe serum directly through the hepatic sinusoids or byway of the space of Disse and the thoracic duct. Tenmale Sprague-Dawley rats weighing 250 -350 gramsunderwent thoracic duct cannulation proximal to the cisterna chyli: five of these also underwent bile duct ligation. Blood samples and cumulative thoracic duct lymphwere collected hourly for twelve hours. AP was determined by a modified Bessey-Lowry method.AP did not rise at any time point in lymph, but wasmarkedly increased in serum by seven hours when compared with control (p < .05), and continued to rise for thenext five hours. Electrophoresis of serum specimens onpolyacrylamide gel showed increasingly intense stainingof the hepatic isoenzyme throughout the study period.Lymph flow averaged 0.6 ml. per hour and did not changesignificantly in either group. Gastric instillation of cornoil led to a five-fold increase in thoracic duct lymph APfive hours after treatment. Molecular weight for sera APfrom bile duct-ligated rats was determined by gelchromatography and found to be approximately 125,000.Thus, hepatic AP molecules probably pass freelythrough the large openings in the sinusoidal endotheliallining and are transported out of the liver chiefly insinusoidal blood, which flows more rapidly than doeshepatic lymph.18 Monitoring the Monitors: Problems of Trace GasMonitoring in the Operating RoomLinda Lee HugheySponsor: Dr. Donald BensonDiscussant: Dr. Jacobus MostertThe issue of trace gas exposure in the operating room hasdemanded a newly-prominent niche in the professionalliterature. The portable infrared trace gas analyzers nowcommercially available are, the manufacturers claim,both inexpensive and accurate. To assess the impact oftrace gas monitoring on anesthetic practice, we comparedthe measurements of two portable nitrous oxide monitorsand observed the reactions of operating room personnelto the practice of monitoring.Ambient levels of 30 -60 parts per million or more ofnitrous oxide were recorded in standard operating rooms.Simple measures of tightening leaking valves and connecting waste gas sources to outside vents with plastictubing minimized the worst leak sources. Serious technical problems plague the monitors tested, namely interference by other gases, calibration inaccuracy, and driftof the gauges.Theoretical problems of monitoring are even more critical. Studies attempting to demonstrate dangers of tracegas exposure and to establish acceptable levels aresuggestive but flawed and often contradictory. Educatingoperating room personnel to the subject of trace gas exposure poses a second problem. Finally, a surprisingamount of antagonism to the concept of trace gasmonitoring exists, often among the very people at highestrisk of exposure. Such antagonism will make the initiation of a trace gas monitoring system difficult to fund andoperate until those who make operating room policy decisions are satisfied that reduction of trace gas levels inthe operating rooms is necessary.Determinants In Survival from Malignant MelanomaDavid KapelanskiSponsors: Drs. George E. Block and Michael KaufmanDiscussant: Dr. Andrew ChurgThe goal of orthodox operative treatment for Stage Imalignant melanoma is excision of all neoplastic tissue.In over half of the patients, this goal will be accomplishedby a wide excision of the primary tumor withoutlymphadenectomy. Elective lymph node excision istheoretically capable of improving the survival rate byremoving the occult metastases while they are amenableto cure. The low incidence of occult nodal metastases(14.8 percent in this series) and the disappointing survivalwhere nodal disease is encountered (20 percent) requirethe establishment of parameters capable of discriminatingthose patients liable to benefit from such intervention.Clark's and Breslow's histologic staging methods haverecently been advocated as discriminate criteria. In a re-trospective analysis of 114 cases of Stage I and II malignant melanoma seen at the University of Chicago, thefive-year recurrence-free survival was 76.9 percent forClark level two, 56.3 percent for level three, 36.4 percentfor level four, and 37.5 percent for level five. The fiveyear recurrence-free survival was 74.2 percent for primaries less than 1.50 mm. thick, and 41.9 percent forprimaries larger than this. Elective regional node dissection significantly improved recurrence-free survival onlyfor level four primaries (p < 0.025). There was no significant difference in survival when local excision andlocal excision plus elective node dissection were compared for level two, three, or five. The histologic type ofthe primary tumor did not significantly alter survival.Primary lesions were also examined for: a) ulcerationgreater than 6 mm.; b) perineural, vascular, or lymphaticinvasion; and c) one or more mitotic figures per highpower field. The absence of these characteristics was associated with a 72.7 percent five-year survival. The presence of one characteristic was associated with 48.1 percent survival, two characteristics with 26.7 percent survival, and three characteristics with a 14.3 percent survival (p < 0.05).The inability of currently-employed criteria to uniformly predict recurrence, and the technical imprecisionof the criteria due to sampling and observer error, whencombined with the high proportion of treatment failure,mitigate against the use of these criteria to select patientsfor an elective operative procedure of limited efficacy.Calcium Oxalate Urolithiasis: An Approach toUnderstanding the Crystallization ProcessJohn W. KareshSponsor: Dr. William GillDiscussant: Dr. Frederic CoeCrystallization of calcium oxalate from urine with retention of the crystal in the papillary duct is the fundamentalprocess involved in the development of stones.Stud y of crystallization theory, the molecular basis ofstone formation, can help us to further understand thefactors involved in stone formation.We have investigated the following pertinent questions:1. Under what conditions will a urine spontaneouslyform calcium oxalate crystals? (the concept of nucleationand the metastable limit),2. How much calcium oxalate will precipitate? (thesupersaturation level), and3. How fast will the precipitate form? (the crystallization rate).We have been able to study these questions in a simplified system, by developing a technique for the production of solutions supersaturated at various levels withradioactively-labelled calcium oxalate in a simple and repeatable manner. These studies have shown that themetastable limit and saturation level are increased, andthe crystallization rate slowed, in water which containssmall ions similar to those found in urine. These results have been extended by studying urinesdialyzed, with macromolecules removed. The macromolecules affected calcium oxalate crystallization by:an inhibition of nucleation (increased metastable limit),an inhibition of the crystallization rate, a decrease in thesupersaturation level, and a decrease in adhesion of crystals to container surfaces.These results have been further extended by studyingurines from normal humans and from those who formstones. In those who form stones the relative level ofsupersaturation with calcium oxalate tends to be higherand the rate of crystal formation faster than in normals.The stone formers seem to have a poorer protectivemechanism against crystallization in urine.The importance of crystallization theory in the evaluation of the stone former and in possible therapies is evident.The Effect of Anesthesia on Renal Hemodynamicsin the RatBruce M. KoeppenSponsors: Drs. Adrian I. Katz and Marshall D. LindheimerDiscussant: Dr. Harold L. BrooksRadioactive microspheres have been used extensively inthe study of intrarenal hemodynamics following numerous physiologic, pathophysiologic and pharmacologicmanipulations. The majority of these studies have beenperformed in the anesthetized dog. However, recentwork in the dog and in the rabbit has shown that anesthesia itself alters intrarenal hemodynamics. In the present study we have adapted the microsphere technique tostudies in the rat, and have determined the effect of anesthesia on renal hemodynamics in this species.Experiments were performed on female SpragueDawley rats weighing 180-220 grams. The animals werestudied either unanesthetized (U) or anesthetized withsodium pentobarbital (P) 50mglkg I. P., or with Inactin (I)120mglkg I.P. Total renal blood flow (RBF) and its intrarenal distribution were determined with Sr-85- and Ce-141-labeled microspheres 15 ± 51L in diameter. RBF wascalculated by a modification of the Fick principle, andcortical distribution was determined for three 500IL zonessliced on a clinical microtome (Zone I = outer cortex,Zone II = mid-cortex, Zone III = inner cortex).RBF(rnl/rnin/g K.W.) %ZONAL DISTRIBUTIONI II IIIU 7.16 43.0 33.6 23.4n= 12 ±.49 ± 1.3 ±1.2 ± 1.1P 4.75c 37.7a 36.0 26.3n=l1 ±.42 ±2.1 ± 1.4 ±1.0I 5.43 b 42.8 33.8 23.4n=13 ±.49 ± 1.7 ± 1.5 ± 1.2(mean ± S.E.M.) a = p < .05; b = p < .025; c = p < .00519The results indicate that both pentobarbital and lnactinanesthesia cause a decrease in renal blood flow, and thatpentobarbital also produces a redistribution of blood flowaway from the outer cortex. These observations underscore the need for caution in interpretation of measurements of renal hemodynamics obtained in anesthetized animals.Lesions of the MyofibrilRalph W. KunclSponsors: Drs. Herbert Y. Meltzer & Ward R. RichterDiscussant: Dr. Louis CohenOne of the disappointments of the myopathologist is thefact that the pathologic reaction of skeletal muscle toinjury is limited, and most of what he sees is non-specific.There are two commonly-occurring myofibrillar lesionswhich are of obscure origin; the lesions are (1) patchyareas of disruption of normal myofibrillar banding, and(2) patchy areas of smearing of the dense Z-band. Theseare extremely common lesions occuring in non-necroticcells in a wide variety of either neurogenic or myogenicneuromuscular diseases. They are not seen on routinelight microscopic preparations of tissue but are seen onthin and ultrathin sections in the phase microscope orelectron microscope.I studied the occurrence of these lesions in an experimental myopathy in which such lesions commonly occur,and in which they are essentially the only significantpathologic change. The myopathy is produced by restraining rats after pretreating them with a psychomotorstimulant. The extent of myopathy is related to theamount of isometric exercise of the constantly strugglinganimal. This study is an attempt to analyze thesecommonly-occurring myofibrillar lesions quantitativelyand qualitatively as they develop over time and in severalmuscle groups. It corrects some misconceptions concerning the pathogenesis of myofibrillar lesions and substantiates an important pathogenic role of the mitochondrion.The predominant lesion in the experimental myopathywas extensive myofibrillar disruption, occurring in50 -60 percent of fibers. This lesion was temporally related to the 30-fold increased plasma CPK activity thatbegins within minutes of treatment. Focal mitochondrialloss occurred subsequent to other mitochondrial abnormalities within areas of myofibrillar disruption. Initially,myofibrillar disruptions contained disoriented, clumped,abnormally-staining mitochondria with changes in thefine structure of the cristae. Only 24 hours after onset ofmyofibrillar disruption were mitochondria typically lostin disrupted foci. This correlated well with a 40 percentreduction in specific mitochondrial activity of succinatecytochrome C reductase (SCR) soon after treatment anda recovery of normal specific SCR activity at 24 hours.Significant Z-band smearing occurred independently ofmyofibrillar disruption, being noted first at 24 hourstreatment.Both myofibrillar lesions also occur in normal untreated control muscles. In control muscles of the lower20 limb, Z-band smearing occurred predominantly inmitochondrial-rich (red) fibers; to the contrary, myofibrillar disruption occurred predominantly in mitochondrialpoor (white) fibers. In both experimental and untreatedmuscle, Z-band smearing occurred predominantly inthose specially-differentiated peripheral areas in themuscle fiber which are immediately adjacent totransversely-coursing blood vessels. These areas normally lack mitochondria.Thus, the focal mitochondrial/ass that occurs in areasof myofibrillar disruption is not of the same significanceas the focal mitochondrial absence in areas of Z-bandsmearing. In the former lesion, focal mitochondrial degradation is an early concomitant and focal mitochondrialloss a subsequent event to the myofibrillar lesion; in thelatter lesion, focal mitochondrial absence provides astructural substratum for the occurrence of a Z-band abnormality.Myofibrillar lesions are common in normal and diseased skeletal muscle. In normal muscle, they may represent a mechanism for myofibrillar turnover and consequent muscle fiber remodeling which is known to occurfollowing change in muscle usage and innervation patterns. In diseased muscle, myofibrillar disruption may becommon because it represents a final common responseto mitochondrial injury from many causes, in this casemitochondrial injury by functional hypoxia. In support ofthis mechanism are the similarity of this myopathy toexperimental ischemic myopathy and the fact that it isblocked by denervation, adrenal demedullation, andbeta-adrenergic receptor blockade-all maneuvers thatreduce the oxygen requirement of the muscle cell.Z-band lesions may be common because they occur specifically in those frequent subcellularly-differentiatedareas of the muscle fiber which are particularly susceptible to injury due to a paucity of mitochondria.Perhaps study of the skeletal muscle mitochondria inthose neuromuscular diseases of obscure etiology inwhich myofibrillar lesions commonly occur will be revealing.Bacillus Subtilis DNA Polymerase III and ItsNovel Inhibition by the 6-p-hydroxyphenylhydrazinopyrimidinesRobert L. LowSponsor: Dr. Nicholas R. CozzarelliDiscussant: Dr. Wolfgang EpsteinAlthough DNA polymerase III is necessary for DNAreplication, prior to this study it had not been characterized adequately. Bacillus subtilis ON A polymerase IIIwas purified 4500-fold to near homogeneity and shown tobe a highly-asymmetric protein consisting of a single165,000 dalton polypeptide. In addition to the polymeraseactivity, the enzyme promotes phosphorolysis of DN Aand contains a potent, intrinsic exonuclease activity. Theexonuclease non-processively degrades single-strandedDNA from the 3' terminus yielding 5'-mononucleotides.Maximal activity occurs on short chains. The exonuc-lease activity probably functions to remove mismatchedbases inadvertently incurred during replication.The 6-p-hydroxyphenylazopyrimidines are antimicrobial agents against a wide variety of gram-positiveorganisms. They selectively inhibit DNA replication andDNA polymerase III. Polymerase III was purified froma drug-resistant B. subtilis mutant and shown to be resistant in vitro, conclusively demonstrating that the enzyme is the drug target in vivo. The molecular mechanismof drug inhibition has been determined. The reduced, active hydrazino form of the uracil drug derivative interactsat the enzyme's nucleoside triphosphate binding site, andsimultaneously hydrogen bonds to a template cytosine,adjacent to the primer terminus of the DNA. Thepolymerase is thereby sequestered into an inactiveDNA-drug-polymerase ternary complex.The ternary complex was isolated by agarosechromatography and shown to have the predicted features. The arylhydrazinopyrimidines are the best understood and most specific ON A replication inhibitorsknown. The ternary scavenging mechanism suggests thatsimilar drug analogues might be designed to inhibit otherpolymerases and thereby provide new avenues of selectively inhibiting DNA synthesis.Hemodynamic Effects of Sodium Nitroprussidein Severe Congestive Cardiac FailureSteven A. LukesSponsors: Drs. Leon Resnekov and Calixto RomeroDiscussant: Dr. Jafar AI-SadirSodium Nitroprusside (NP) is a systemic vasodilator thathas recently been used in attempts to improve cardiacfunction by decreasing left ventricular afterload. Underclose hemodynamic monitoring, NP was administered tosixteen patients with severe congestive cardiac failure.Ten patients (responders) demonstrated marked improvement in clinical and hemodynamic parameters. Sixpatients (nonresponders) demonstrated no overall improvement, despite transient benefit in four. Initial leftventricular filling pressure (LVFP) was higher in the responder than in the nonresponder group (37 ± 3 vs. 27 ±1 mm Hg, p < 0.025), as was systemic vascular resistance(SVR) (2510 ± 150 vs. 1730 ± 250 dynes-sec-em - 5, p <0.05). All ten responders had SVR greater than 1900dynes-sec-em -5, while five of the six nonresponders hadSVR less than 1800. Thus, SVR and L VFP appear to behelpful in predicting the response to NP infusion in patients with congestive failure.The Production of Single Digit Numbers by Subjects with Normal and Impaired Cognitive FunctionRobert P. MarcincinSponsor: Dr. Charles M. CulverDiscussant: Dr. Robert Cohen A simple "paper and pencil" technique in which subjectsgenerate sequences of single digit numbers is describedand investigated as a potential test of a patient's mentalstatus. The task is different from most tests of cognitivefunction in that it requires a sustained production of information output with no given conceptual structure inwhich to operate. Hence, it might prove sensitive to evenmild degrees of cortical dysfunction.This study contrasted the ability of subjects with mildcognitive impairment and a matched group of unimpairedcontrols to perform the number generation task.Twenty-four subjects were assigned to each group on thebasis of standardized neuropsychological test results.They were matched for sex, age, and level of education;all were judged to be without focal neurological deficits.Subjects were given a paper and pencil and asked torandomly write as many single digit numbers as possiblein a two-minute period. Each SUbject's data output wasanalyzed with a series of computerized tests that wereconstructed to measure diverse properties of a numberseries.The results indicate that the two groups differ significantly on several parameters of their number production. Subjects are seen to create patterns in their numberseries that are group specific.These findings demonstrate that the test is sensitive tomild degrees of cortical dysfunction. Criteria for correctinterpretation of results of the test and proper classification of patients are developed.The Development of Immune Reactivity toTumor in Immunized and Non-Immunized MiceAnthony A. MeyerSponsors: Drs. Robert L. Hunter and Robert W. WisslerDiscussant: Dr. Warren E. EnkerThis project was undertaken to study how the immuneresponse to a tumor changes with time and tumor growth.It also investigated the effect of pre-immunization onhow this response changes. The MKS-TU5 tumor system in Balb/c mice was used for this study because of itsstrong immunogenicity. Initial experiments characterizedthe tumor system with respect to the rate of growth oftumor and the dose of irradiated cells required for successful immunization.Next, three assays of immune reactivity were selectedand standardized for this system; they were blast transformation, the Winn test, and lymphoid and tumor tissuemorphology.With the preliminary studies accomplished, the development of immune response to tumor was investigated.Animals received tumor transplants and the growth oftheir tumors was followed. The growth period could bedivided into three phases, an initial phase of slow growth,followed by a phase of rapid growth, and a final phase ofreduced growth when the animals approach death. Animals with tumors in each of these phases were selectedrandomly, sacrificed, and studied using the three testsmentioned previously.21Analysis of the results revealed that animals demonstrated increasing, significant reactivity to their tumorseven in late phases of tumor growth as measured by allthree tests. In the blast transformation data was revealeda loss of reactivity during the phase of rapid tumorgrowth, but this was temporary.Animals immunized prior to tumor transplant werestudied in the same manner. Immunized animals who rejected tumor grafts had immune reactivity that rose morerapidly than that of non-immunized animals. However,those immunized animals who failed to reject theirtumors also failed to demonstrate a significant rise in immune reactivity to the tumor.The results of this study reveal two major points. First,the immune response to tumor can continue to increasewhile the tumor grows rapidly. This indicates that insome clinical situations induction of tumor immunity in apatient may have no effect on his cancer. Second, inadequate immunization may not only fail to protect thehost, but also may prevent the development of an immune response to tumor. Such effects would have to beconsidered in a vaccination program for cancer prevention.This study has provided some useful information aboutthe development of immune reactivity, but it has raisedmore questions and hopefully can serve as a basis fortheir investigation.A Bovine Brain Protein Kinase: An Analysis ofProtein Kinase Mechanism and StructureGeorge W. Moll, Jr.Sponsor: Emil T. Kaiser, Ph.D.Discussant: Josef Fried, Ph.D.The cAMP-dependent protein kinases have been implicated as the primary mediators of intracellular cAMPaction. They are thus suitable for the study of the molecular mechanism of action of cAMP.Our preliminary studies of the bovine brain cAMPstimulated protein kinase suggested a covalent cAM Penzyme intermediate, but the available methods for purification yielded an enzyme preparation which was inadequate for detailed mechanistic studies. A procedurewas devised which yielded two highly purified cAM Pstimulated bovine brain protein kinases, one of whichwas stable (PKI) and another less stable (PKII). Noother protein kinases or cAM P-binding subunits wereisolated. The molecular weight of PKI was 162,000 ± 7percent and that of PKII was 83,000 ± 7 percent MWdetermined by gel filtration, analytical ultracentrifugation, and amino acid analysis. SOS gel electrophoresisindicated single sub-unit molecular weights of 73,000 forPKI and 85,000 for PKIl.The data suggested that PKI was formed from twoPKII species and might be the first cAMP-stimulatedprotein kinase with both catalytic and regulatory activityon the same protein subunit. A new protein kinase assayemploying PEl-cellulose thin-layer sheets was devisedwhich permitted 14C-labelled ATP to be used for the first22 time as a protein kinase substrate. This assay was ofgreat help in elucidating the mechanism of action of PKI.The inhibitory effect of metal ions commonly found inprotein kinase assays fits a general ionic strength inhibition model for PKI phosphorylation of histone. Theseexperiments set the stage for future studies concerningthe molecular interaction of cAMP with PKI, and raisesome interesting points regarding the enzymatic mechanism of protein kinases in general.The Development of Cell-Mediated Immunity inMice with Mammary TumorsNancy J. OlsenSponsor: Dr. Robert HunterDiscussant: Dr. Warren E. EnkerHuman breast cancer has been shown to be associatedwith various immune responses. The development ofcell-mediated immunity was studied in the C3HBAmouse mammary tumor system. Antigens were preparedfrom mouse and human tissues by the method of KClextraction. Spleen cells from tumor-bearing mice wereused in two in vitro assays of cell-mediated immunity:inhibition of the migration of macrophages and stimulation of lymphocyte blastogenesis.U sing the agarose droplet method of MIF assay, antigen-specific inhibition of cells from C3HBA mice wasobserved. In addition, antigenic stimulation of spleencells from immunized mice resulted in the production ofMIF activity. In the blast transformation assay, cellsfrom C3 H BA mice had depressed responses to the mitogen Concanavalin A. A peak of blast activity in responseto antigenic stimulation occurred six to seven weeks aftertumor transplant. Mice who received antigen immunization prior to tumor challenge had higher stimulation indices in this assay.An in vivo assay in mice compared the effects of immunization with the KC 1 extracts. The normal humanbreast extract inhibited tumor growth, while extract of ahuman breast tumor enhanced the lethality of theC3HBA tumor.The human and C3HBA tumors appear to share antigens, morphology and immunological mechanisms. TheC3HBA tumor is a model for the study of human breastneoplasms which may further elucidate immunologicmechanisms in this disease.The Existence of Tolerance to and CrossTolerance between {i-Amphetamine andMethylphenidate in the RatRonald G. PearlSponsor: Lewis S. Seiden, Ph.D.Discussant: Dr. Charles R. SchusterAdministration of {i-amphetamine (2.5 mg/kg) or methylphenidate (20 mg/kg) decreased milk consumption in rats.When these drugs were administered daily, tolerance de-veloped to this effect over the course of 20 days. Crosstolerance to the effects on milk consumption occurredbetween g'-amphetamine and methylphenidate over a4-fold range of dose of both drugs. Administration ofg'-amphetamine (l.5 mg/kg) or methylphenidate (10mg/kg) disrupted responding under differentialreinforcement-of-low-rate (DRL) contingencies. Bothdrugs increased response rate, decreased frequency ofreinforcement, and shifted the mode of the interresponsetime distribution to the left. When the drugs were administered daily, tolerance developed to all these effectsover the course of 20 days.Cross-tolerance to the effects on DRL behavior occurred between g-amphetamine and methylphenidateover a 4-fold range of dose of both drugs. Daily administration of d-amphetamine (2.5 mg/kg) but not of methylphenidate (20 mg/kg) resulted in decreased norepinephrine levels in brain; the decreased norepinephrinelevels which occur with repeated £i-amphetamine administration are believed to result from the storage innoradrenergic neurons of p-hydroxynorephedrine, ametabolite of g-amphetamine. Radioactivity was not detectable in rat brain 24 hours after the last of 15 dailydoses of radio-labeled methylphenidate.These results suggest that g'-amphetamine, but notmethylphenidate, is metabolized to a compound which isstored in noradrenergic neurons. The existence of behavioral cross-tolerance between £i-amphetamine andmethylphenidate is therefore inconsistent with thehypothesis that tolerance to the behavioral effects of£i-amphetamine is due to the metabolism ofg'-amphetamine to p-hydroxynorephedrine, a falsetransmitter in noradrenergic neurons.Lead Encephalopathy: A Study of Altered Vascular Growth, Capillary Permeability andNeuronal Development in an Animal ModelMichael F. PressSponsor: Winston Anderson, Ph.D.Discussant: Dr. Edward GanzLead encephalopathy was produced in neonatal LongEvans rats by administering daily doses of lead acetate(600 milligrams of lead acetate per kilogram of bodyweight) through an esophageal catheter. Experimental ratpups showed behavioral changes, failed to gain weight atthe same rate as controls, developed a paraplegia, anddied by fifteen days of age. Lead analysis showed veryhigh blood and tissue lead levels.Sequential histopathologic changes were studied in thecerebellum at the light and electron microscopic levels.Observations were also made in the choroid plexus,cerebral cortex and corpus striatum. In the cerebellum,petechial hemorrhages were present at three days, at fivedays extensive hemorrhagic lesions were observed, andthereafter until death there was a progressive accumulation of fluid in extracellular spaces.Developmental changes in cerebellar neurons wereexamined in Golgi preparations and by electron micro- Michael PressDavid SalesBurton Vander LaanRichard Walker Alan RushtonJohn Scarlett IIISherwin WaldmanJack Weiss23scopy. Matrix cells and neuroblasts of the external granular layer were minimally altered prior to day eight, butthereafter the number of mitotic figures per folium decreased moderately and the number of pyknotic cells increased markedly. Purkinje cells survived the cerebellaralterations of lead encephalopathy well for the first five toeight days. However, the rate of Purkinje cell maturationover "edematous cavities" was retarded after ten days.Vascular malformations were studied with electronmicroscopy, ultrastructural tracers (horseradishperoxidase) and Golgi preparations. Functional andmorphologic alterations were observed in the developingendothelium as early as three days of age. The evidencesuggests that growing capillaries (angioblasts) are a primary central nervous system structure damaged by leadintoxication.Genetic Linkage Studies of the Human Glvcosphingolipid ,B-GalactosidasesAlan R. RushtonSponsors: Drs. Glyn Dawson, Albert Dorfman, and JanetRowleyDiscussant: Dr. Allen L. HorwitzGlycosphingolipids are important membrane components of all eukaryotic cells. They also occur as the majorstorage material in a number of inherited human lipidstorage diseases. Galactosylceramide (Gal (,BH I) Cer)is stored in Krabbe's disease; lactosylceramide (Gal (,Bl-74) GIc (,BH I) Cer) accumulates in lactosylceramidosis;and the ganglioside GMI (Gal (,B1� 3) GalNAc (,B1� 4)[NANA (ah 3)] Gal (,Bl-7 4) GIc (,Bl-7 I) Cer) is stored inGMI generalized gangliosidosis. Each of these disorders isinherited as an autosomal recessive and is characterizedby deficiency of a specific f3-galactosidase activity towardthe stored glycosphingolipid. These observationssuggested the existence of three human f3-galactosidases.The genetic linkage relationships of the human glycosphingolipid f3-galactosidases were determined using twoindependent series of human-mouse somatic cell hybrids.A new method was devised for the estimation of humanGalCer, LacCer and ganglioside GMI f3-galactosidase activities in the presence of their mouse counterparts,based on differences in both pH optima and sensitivity tochloride ion. A ratio was defined for each activity whichwas the specific activity at the human pH optimum divided by the specific activity at the mouse pH optimum.Hybrid cells containing both human and mouse enzymeswere expected to have pH ratios intermediate betweenthose characteristic of the human and mouse parentalcells. The pH ratios for f3-galactosidase activity towardthe three glycosphingolipids were determined in approximately twenty hybrid cell clones.Human and mouse chromosomes were identified inthese same hybrid cell lines by their characteristic banding patterns after staining with quinacrine mustard. Themethod of linear regression analysis was then used to testfor concordant segregation between pH ratios for eachf3-galactosidase activity and for the frequency of occur-24 renee of different human chromosomes in the humanmouse hybrid cell strains.The results from two independent series of hybrid cellclones indicated that human f3-galactosidase activitiestoward the three glycosphingolipids, GalCer, LacCerand ganglioside GMI, consistently segregated with humanchromosome C-12.Serum Apolipoprotein Abnormalities in DiabeticRatsDavid SalesSponsor: Dr. Godfrey GetzDiscussant: Dr. Arthur RubensteinDiabetics often have hyperlipidemia and prematureatherosclerosis. Rats rendered diabetic with streptozotocin injection developed hyperlipidemia associated withincreased levels of very low density lipoprotein (VLDL),characterized by a lower proportion of arginine-rich peptide and a higher proportion of apolipoprotein C-II (a poC-II) relative to apo C-III-O. This apo C abnormality wasfound in all sizes of VLDL as well as in HDL of diabeticrats, and treatment of the diabetic rats with insulin in vivoreversed these changes.To investigate the origin of the diabetic abnormalities,the synthesis, secretion and turnover of the apolipoproteins of VLDL were studied. Isolated perfused liversfrom diabetic rats produced VLDL with apo C abnormalities similar to those seen in their plasmas. Turnoverof the various apoproteins was unaltered. Thus, an abnormal balance in the hepatic synthesis of VLDL apoproteins probably accounts for the changes seen in diabetes. Since the apo C's are regulators of lipoproteinlipase, these abnormalities may represent an adaptationto the defective removal of plasma triglycerides encountered in diabetes.Diagnosis of Factitious Hypoglycemia by Measurement of Plasma C-Peptide Reactivity andInsulin-Binding AntibodiesJohn A. ScarlettSponsor: Dr. Arthur RubensteinDiscussant: Dr. David HorwitzSeven patients with factitious hypoglycemia due to thesurreptitious injection of insulin are described. The diagnosis was made by measurements of plasma insulin andC-peptide immunoreactivity (seven patients) and wasfacilitated by the finding of circulating insulin-bindingantibodies (two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulinand suppressed C-peptide immunoreactivity represent atriad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide andfree insulin permitted insulin-requiring diabetic patientswith unexplained hypoglycemia to be studied and diagnosed in a similar way to non-diabetic subjects.Prostaglandin Metabolism m MyeloproliferativeDiseaseBurton F. Vander LaanSponsor: Dr. Juan ChediakDiscussant: Dr. Margaret TelferPlatelet aggregation as a diagnostic tool is being increasingly utilized in both routine and research laboratories, and several new agents capable of inducing thisresponse have recently been described. One such substance is arachidonic acid, which acts via conversionwithin the platelet to certain prostaglandin metabolites.Since the response can be correlated with the levels ofvarious prostaglandin metabolites, it seems that thesesubstances are responsible for the in vitro platelet aggregation.In studying platelet aggregation in various conditions,it became evident that platelets from patients withmyeloproliferative disorders behaved differently thannormal platelets. Since the exact pathogenesis of thehemostatic defects in these patients is unknown, a studywas undertaken of the platelet function and prostaglandinmetabolism in these disorders. One such patient exhaustively studied had a significant bleeding tendency as wellas a refractory anemia, neutropenia and thrombocytosis,and illustrated that the abnormality may reside in an ineffective production of prostaglandin metabolites withinthe platelet. Initial evaluation showed a prolonged bleeding time, abnormal platelet aggregation, abnormalplatelet electron microscopy and deficient 14C_ serotoninrelease. Measurements of one of the main prostaglandinmetabolites, malondialdehyde, disclosed reducedamounts, and platelet adenine nucleotides were at thelower limit of normal. Similar results were obtained in agroup of controls following the ingestion of aspirin,known to interfere with prostaglandin synthesis.It is possible to speculate that patients with myeloproliferative disorders produce an abnormal clone ofplatelets defective in the synthesis of prostaglandins, thusexplaining the bleeding tendency or the in vitro abnormalities observed.Changes in Venular Resistance by Sticking WhiteBlood Cells in Hemorrhagic HypotensionEffects of Heparin, Methyl Prednisolone, Dextran 40 and Normal SalineSherwin WaldmanSponsors: Drs. Robert Replogle and Elof ErikksonDiscussant: Dr. Gerald MossIn hemorrhagic shock, the increased vascular resistancedue to vasoconstriction is well described. The contribution to the vascular resistance by wall-adhering whiteblood cells (WBCs) is less appreciated. In this study,using in vivo microscopy, it was attempted to quantitatethe contribution of sticking WBCs to venular resistance.In anesthetized rats, the exposed mesentery was observed in the microscope. The femoral artery and vein were cannulated for blood pressure measurements andintravenous injections. The number of sticking WBCswas counted in a venule of approximately 25 ILm diameter and 215 ILm length, before and after the rat was bledby 30 percent of its total blood volume, and at subsequentadministration of different pharmacological agents. During control conditions, 1-2 WBCs adhered, and afterbleeding, 8.When heparin (200 IU/kg) was given following hemorrhage, the number increased to 11, while the administration of methyl prednisolone (30mg/kg) after hemorrhageresulted in a decrease to 4. Neither dextran 40 (50 percentof bled volume) nor saline (150 percent of bled volume)affected WBC adherence. Theoretical calculations revealed a 400-fold increase in venular resistance caused bythe adherent WBCs.Control of local Cerebral Blood Flow by CentralAdrenergic MechanismsRichard H. WalkerSponsor: Dr. Jack de la TorreDiscussant: Dr. John MullanThe cerebral vasculature consists of two systems: extraparenchymal and intraparenchymal vessels. Extraparenchymal vessels are known to be innervated by theperipheral sympathetic system via the superior cervicalganglion.Histofluorescence of catecholamines was used to demonstrate adrenergic varicosities on forebrain intraparenchymal arterioles in dogs and monkeys havingundergone bilateral superior cervical ganglionectomy.This finding suggests intraparenchymal microvessel innervation by a central adrenergic system, presumablyoriginating in the brain stem locus coeruleus and projecting rostrally via the ipsilateral noradrenergic dorsal tegmental bundle, with little or no contralateral crossover.To study the effect of unilateral electrical stimulationof the locus coeruleus on local cerebral blood flow bilateral pre-stimulation and post-stimulation blood flow recordings using hydrogen clearance were made stereotaxically in three discrete forebrain regions in rats havingundergone bilateral superior cervical ganglionectomy.Post-stimulation flow recordings showed: 1) a mean reduction in local cerebral blood flow of 40, 65, and 70percent from pre-stimulation baseline flow rates in forebrain regions ipsilateral to stimulation and 2) no significant change from pre-stimulation flow rates in forebrain regions contralateral to stimulation.The mechanism suggested by this evidence is that electrical stimulation of an adrenergic center, the locuscoeruleus, can affect catecholamine release at adrenergicterminals located on ipsilateral intraparenchymal forebrain microvessels in the regions studied, and causealteration of local cerebral blood flow. Other studies haveshown that pharmacologic stimulation of the locuscoeruleus with carbachol causes reduced cerebral bloodflow and that alpha receptor blockade with intraventricular phentolamine causes increased flow.25Knowledge of the mechanism of regulation of cerebralblood flow is applicable to treatment of head injury andcerebral vascular insult in humans.Transmural Distribution of Ischemia: Variationin Canine and Porcine HeartsJack L. WeissSponsor: Dr. Harold L. BrooksDiscussant: Dr. John J. LambertiThe transmural distribution of blood flow before and during regional ischemia was compared in canine and porcine hearts-two animal models currently in wide use formyocardial infarction studies. Open-chest, chloraloseanesthetized dogs (10) and pigs (16) of comparable heartsize were studied. Technecium-99m-labeled albuminmicrospheres (1.0-1.5 million, 15-30 J.L) were injectedinto the left atrium and allowed to circulate for 30 seconds following occlusions of arteries of varying sizes.The heart was excised, quickfrozen, and the ventriclescut into 1.0 ern" pieces, with each piece sectioned intoepicardial (Epi) and endocardial (Endo) halves. Transmural blood flow gradients were expressed in terms ofEpiJEndo flow ratios.No significant transmural flow gradient was demonstrated across the canine left ventricular free wall, eitherin the control (1.15 ± .15) or the ischemic (1.04 ± .19)state. In contrast, the porcine left ventricular free walldid yield a significant transmural blood flow gradient atthe 0.05 level of significance both at control (0.81 ± .04)and following two minutes of ischemia (0.51 ± .05).Hemodynamic parameters were comparable in bothspecies.The resting flow patterns can be explained by previousanatomical studies which have shown the canine heart tohave extensive, predominantly epicardial interarterialanastomoses while the porcine heart, similar to that ofthe human, has fewer anastomoses which are locatedprimarily in the endocardial layer. Anatomy of the coronary collaterals may also be the determining factor in thetransmural distribution of ischemia.SENIOR SCIENTIFIC SESSION WINNERSTwo awards were presented to students for theirexceptional presentations at the Senior Scientific Session. They received their awards at theMedical Alumni Banquet on June 8. The Medical Alumni Prize for the best oral presentationwas awarded to Robert Low, who is taking hisresidency in pathology at Stanford University.The Catherine L. Dobson Prize for the best oralpresentation by a non-Ph. D. student wasawarded to John Karesh, who has begun a residency in medicine at Northwestern UniversityMedical Center.26 Lester WoldRelationship of Lysosomal Enzyme Activity toCoagulation and AtherosclerosisLester WoldSponsor: Dr. Robert W. WisslerDiscussant: Dr. John L. SkoseyRecent experimental evidence suggests that lysosomesplay an important role in the accumulation of lipid in theatherosclerotic plaque. This study attempts to explorethe relationship between lysosomal enzymes and thesmooth muscle cellular proliferation observed in humanatherosclerosis as well as in experimental models utilizing "conditioned media."Human blood was used to prepare whole blood serum(WBS), platelet-rich plasma serum (PRPS), andplatelet-poor plasma serum (PPPS), which were thenanalyzed for alpha-mannosidase, beta-glucuronidase,acid phosphatase, cathepsin 0 and peroxidase activity.The WBS alpha-mannosidase activity was greater thaneither PRPS or PPPS, but the PRPS-PPPS differencewas not statistically significant. The order of betaglucoronidase activity was WBS > PRPS > PPS (all differences being significant). WBS acid phosphatase wasgreater than PPS (WBS-PRPS and PRPS-PPS differences were not significant). No sample showed discernible cathepsin 0 or peroxidase activity."Conditioned media" prepared with monkey blood included five percent WBS, five percent PPS and five percent PRPS with a supernatant of granulocytes incubatedwith zymosan (ZIG). Rabbit blood was used to prepare amacrophage-conditioned media (MCM). Order ofalpha-mannosidase activity was MCM > WBS > PPPS> ZIG. The order of beta-glucoronidase activity wasWBS > MCM > ZIG> PPPS. Assay of acid phosphatase activity showed no difference between five percent WBS and five percent PPS. No sample showed appreciable cathepsin 0 or peroxidase activity.These results suggest that cellular elements as well asplatelets release lysosomal enzymes during in vitrocoagulation. The differences in enzyme activity of the"conditioned media" are also consistent with a role forlysosomal enzymes or their products in the stimulation ofin vitro cell growth.The old order changeth,yielding place to the new.-TennysonName Graduation YearHome Address TelephoneCity, State, ZipBusiness Address TelephoneCity, State, ZipTitleNew address?New position?New medical practice?military assignment?civic or professional honor?book?Please tear out; fold, staple, or tape; and drop in the mailbox. Thanks!-- - -- - -- - - - -- -- --- --- _- -- -- -_---- --- ---- - -- - - - - -- - - - -- ---- - - -_-:r;;; Medical Alumni Association�� 1025 East 57th Street�I Chicago, Illinois 60637 '--------1I II II Place II II Stamp II II Here II I� J------------------------------------------------------Fold this flap in firstResidency Assignments for 1977Ninety-four of the 96 graduating senior medical studentsin the Pritzker School of Medicine participated in thisyear's National Internship and Residency Matching Program (NIRMP). They were joined by three other recentgraduates: one who graduated in December 1976, andtwo who graduated in 1974 but postponed their residencies while they engaged in research activities. Of thetwo graduating seniors who did not participate in theNIRMP, one will enter a residency in emergencymedicine which was not listed in the national matchingprogram, and the other intends to postpone his residencywhile he engages in graduate studies in physiology at theUniversity of Illinois. This brings the total number of ourgraduates who will enter residencies in 1977 to 98.One married couple in the graduating class arrangedfor their postgraduate clinical appointments prior to theactual matching process in a procedure that is permissiblefor married couples under N IRMP guidelines.Almost 90 percent (86) of the 97 individuals who participated in the national matching program received appointments in residency programs which filled all of theirallocated positions in the NIRMP. Similarly, of the 68hospital units where these students began their residencyassignments on July 1, 85 percent (58) filled all of theirallocated positions in the NIRMP.Five students who participated in the matching program and were unmatched were subsequently placed inexcellent hospitals. In two instances, unmatched students were placed in hospitals-the University of OregonMedical Center and the Medical College of VirginiaHospitals-which had actually filled their quotas, butwhich had made additional spaces available subsequentto the matching. The other three unmatched studentswere placed in hospitals which had not filled all of theirallocated positions through the matching program. It issignificant that three of the five unmatched studentssought and secured residencies in internal medicine, adiscipline in which 87 percent of all residencies in theUnited States were filled by the NIRMP in 1977.All first-year postgraduate clinical appointments are now designated as residencies. There are three types offirst-year residencies: categorical, analogous to straightinternships in the past; diversified, analogous to mixedinternships in the past, with the major component beingin a specific clinical discipline; and flexible, similar toprevious rotating internships.The 98 University of Chicago graduates now beginningtheir residencies are distributed among the various disciplines as follows: almost half-46-will be in internalmedicine, 18 will be in pediatrics, and 13 will be insurgery, including one in neurosurgery. Here is the complete distribution by clinical disciplines:Anesthesiology IEmergency Medicine 1Family Practice IFlexible 3Internal Medicine 46Neurosurgery IObstetrics and Gynecology 5Ophthalmology 1Pathology 5Pediatrics 18Psychiatry 2Radiology 2Surgery 12Total 98"The success of our students in the N I RMP can bedirectly attributed to the excellent cooperative efforts ofour students and our faculty members," says JosephCeithaml, Dean of Students. "The members of theCommittee on Residency Placement of Senior MedicalStudents, and Committee chairman Dr. RichardRothberg, should be commended for the time and effortthey expended on behalf of our senior medical students.Finally, the various departmental subcommitteesespecially the one in medicine, since fully one-half of theclass sought residencies in internal medicine-meritpraise for their part in counseling the students on theirchoices of hospitals."Bronx Municipal H. Ctr. (I)Case Western Reserve Affil. H. (2)Childrens H., Boston (I)Childrens H., Philadelphia (I)Childrens Memorial H., Chicago (I)Cincinnati General H. (I)Good Samaritan H., L.A. (I)Gorgas H., Canal Zone (I)Hahnemann Med. Coil. H. (I)L.A. County H./USC Ctr. (2)L.A. County Harbor Gen. H. (2)Lorna Linda Univ. H., Calif. (I)Mary Imogene Bassett H., N.Y. (I)Massachusetts General H. (I)Mayo Graduate Sch. of Med. (3) Medical College of Va. H. (2)Michael Reese Hospital (7)Montefiore H. Ctr., N.Y. (I)Mt. Zion H., San Francisco (I)New York Univ, Med. Ctr. (2)North Carolina Memorial H. (I)Northwestern Univ. Med. Ctr. (3)Ohio State Univ. H. (I)Presbyterian, Univ. of Pa. Med. Ctr. (I)Presbyterian-St. Lukes H. (1)St. Louis Childrens H. (I)San Diego County Univ. H. (3)Stanford Univ. H. (3)Toledo Affil. H. (I)U. of Calif. Affil. H., Davis (I) U. of Calif. H., L.A. (2)U. of Calif. H., San Francisco (3)U. of Chicago H. (23)U. of Colorado Affil. H. (I)U. of Illinois Affil. H. (I)U. of Iowa H. (I)U. of Michigan Affil. H. (4)U. of Oregon Med. Ctr. (I)U. of Pennsylvania H. (3)U. of San Antonio Teaching H. (I)U. of Texas, S. W. Affil. H. (I)U. of Washington Affil. H. (I)U. of Wisconsin H., Madison (2)Vanderbilt Univ. Affil. H. (I)Yale-New Haven Med. Ctr. (3)29News BriefsRicketts AwardDavid S. Hogness, Professor ofBiochemistry at Stanford University, delivered the 1977 Howard Taylor RickettsAward Lecture on May 16. His topicwas "The Arrangement of Genes inDrosophila as Studied by RecombinantDNA."Hogness utilizes a recombinant ON Atechnique to insert fragmentary DNAfrom Drosophila melanogaster (the fruitfly) into small infective virus-like DNAmolecules called plasmids. These circular hybrid plasmid-Drosophila are thenused to infect Escherichia coli bacteria.When theE. coli reproduce, the hybridplasm ids also multiply, producing largeamounts of one small piece of DrosophilaDNA that can be extracted from thehybrid DNA.Hogness utilizes this abundant sourceof Drosophila ON A fragments to studythe as yet unknown code for gene regulation.He is a member of the NationalAcademy of Sciences and the AmericanAcademy of Arts and Sciences, andserved in 1975 as a member of the National Institutes of Health AdvisoryCommittee on Recombinant DNA. Hewas recently appointed a member of thePresident's National Cancer AdvisoryBoard.He is the son of the late Thorfin R.Hogness, who was for many years Professor of Chemistry and Director of theInstitute of Radiobiology and Biophysicsat the University of Chicago.Quantrell Award for SwiftHewson H. Swift was one of three University of Chicago faculty members whoreceived the University's L1ewellenJohn and Harriet Manchester QuantrellAwards for Excellence in Undergraduate Teaching at the University's363rd Convocation on June II.Swift, the George Wells Beadle Distinguished Service Professor in the Departments of Biology and Pathology, theCollege, and the Committee on Genetics, teaches a yearly course on cell biology for juniors and seniors in the College. He is a member of the NationalAcademy of Sciences and the AmericanAcademy of Arts and Sciences and is aspecialist in the role and arrangement ofDNA in cells. He holds a B.A fromSwarthmore, an M.S. from the University of Iowa, and a Ph.D. from Columbia. Hejoined the University of Chicagofaculty in 1949.30 The annual Quantrell awards, thoughtto be the oldest prizes for outstandingteaching in the nation, were establishedin 1938 by an endowment from ErnestQuantrell, a Trustee of the University.Nominations for the QuantrelJ Awardsare made by an appointed committeewhich invites recommendations fromstudents. The prize winners are designated by the President upon recommendation of the Dean of the Collegeand the Provost.Seiden Receives Research Scientist AwardUniversity of Chicago pharmacologistLewis S. Seiden (B.A. '56, B.S. '58,Ph.D. '62) has been selected for a Research Scientist Award by the NationalAdvisory Mental Health Council, sponsored by the United States Departmentof Health, Education and Welfare.The award, which began in July, provides five years of council support forSeiden's research in neuropharmacologyand behavioral pharmacology. He is aProfessor in the Departments of Pharmacological and Physiological Sciencesand Psychiatry, and in the College.Seiden is coauthor of a recently published introductory textbook on researchliterature in experimental psychopharmacology, entitled Psychopharmacology: A Biochemical and Behavioral Approach. which presents current data onthe effects of drugs on behavior.Cowan Receives Humboldt AwardJack D. Cowan, Professor in the Department of Biophysics and TheoreticalBiology and in the College, is the recipient of a Senior U.S. Scientist Award(Humboldt Award) from the Alexandervon Humboldt Foundation in Bonn. According to the Foundation, this award ismade "to outstanding U.S. scientists inrecognition of past accomplishments inresearch and teaching, and thereby promoting scientific cooperation betweeninstitutions in the Federal Republic ofGermany and the United States ofAmerica."Cowan will be at the Max-PlanckI nstitut fur Biophysikalische Chemie inGottingen from March through September. There he will collaborate with Manfred Eigen and Otto Creutzfeldt on problems such as the stability and origin ofbiological information, particularly in relation to the development of specificityand diversity in the immune response,and the development of specific longrange interconnections in the vertebratenervous system.He has also been invited to visit theMax-Planck-Institute for BiologicalCybernetics in Tub inge n , the MaxPlanck-Institute for Psychiatry in Mun- chen, the Institute of TheoreticalPhysics, the University of Stuttgart, andthe University of Freiburg.Wissler Cited for ResearchDr. Robert W. Wissler received a 1977Distinguished Achievement Award fromModern Medicine magazine for "hismeticulous investigations into the natureof atherosclerosis, particularly his demonstration of the reversibility ofatherosclerotic lesions."He is one of eleven physicians andbiomedical researchers honored for important contributions to research, clinical medicine and surgery, and medicaleducation. The eleven were selected bydeans of medical schools, leaders of professional organizations, and members ofthe magazine's editorial advisory board.Wissler is the Donald N. Pritzker Distinguished Service Professor in the Department of Pathology and Director ofthe Specialized Center for Research inAtherosclerosis.Emmet Bay lectureThe 1977 Emmet Bay Lecture was presented on May 4 by Dr. llza Veith, Professor and Vice-Chairman of the Department of Health Sciences and Professor of Psychiatry at the University ofCalifornia, San Francisco. She spoke on"Medicine as an Academic Discipline atthe University of Chicago."Veith was an Associate Professor inthe Department of Medicine at the University of Chicago from 1959-64. She iscoauthor, with Dr. Franklin C. McLean,of Medicine at the University of Chicago(1952).Kieff Wins Jaycees AwardDr. Elliot Kieff, Associate Professor inthe Departments of Medicine and Microbiology and in the Committee on Virology, was chosen one of Chicago's TenOutstanding Young Citizens for 1977 bythe Chicago Jaycees, a civic organization. He received his award at an awardsbanquet held April 16 at the PalmerHouse in downtown Chicago.Alumni HonoredDr. Dean C. Burns (S.B. ' 16, M.D. '21)and Dr. Harriet E. Gillette (S. B. '37,M.D. '40) were honored by the University of Chicago Alumni Association atthe 37th Annual Awards Ceremony onJune 4.Dr. Burns received a Public ServiceCitation for "creative citizenship andexemplary leadership in community service."He is Founder and Director Emeritusof Burns Clinic Medical Center inPetoskey, Michigan, which has broughtthe services of 60 medical specialists tothe people of northern Michigan. In the1930s, with the help of summer residentsand the local population, he rebuilt LittleTraverse Hospital, which is now a 200-bed medical care facility for the people ofthe region. He served as chairman of acommittee which conducted a feasibilitystudy for a community college in 1957.Two years later, North Central Michigan College was established in Petoskey.Dr. Burns serves as Chairman of theBoard of Trustees.Dr. Gillette received a ProfessionalAchievement Award, which recognizesalumni whose attainments in their vocational fields have brought distinction tothemselves, credit to the University, andbenefits to their fellow citizens.She is retired Director of PediatricRehabilitation at the Rehabilitation Institute of Chicago, and has been apioneer and major contributor in the fieldof pediatric rehabilitation, especially inthe care of patients with cerebral palsy.Student HonorsMichael H. Perlin of Los Angeles hasbeen named the first recipient of theIsaac Anderson Loeb Scholarship forundergraduate research at the Universityof Chicago. Perlin, a third-year Collegestudent concentrating in biology, is conducting enzyme research in the microbiology laboratory at Billings Hospital. From this experience, he hopes tofurther develop his interest in cancer research.Perlin ranks second in his class of 780students. He has consistently earned aplace on the Dean's List at the University. He has been acti ve in the HillelFoundation, the Film Society, and theDebate Club, and he has served as a volunteer at Billings Hospital.The Loeb Foundation was establishedon the death of Mr. Loeb in 1954. Itspurpose is to assist bright, young scholars at the graduate and undergraduatelevel to pursue studies in the agriculturaland biological sciences. The FoundationMichael Karbowski (left) has provided individual scholarships formore than 500 university students inscores of colleges and universities in theUnited States. This scholarship is thefirst the Loeb Foundation has endowed.MichaelKarbowski, Ph.D., a freshmanmedical student, won first place in theRoche Laboratories Award in Neurosciences, and third place in the MeadJohnson Award, the Excellence of Research Award. He received the awardsfor his research work on "The Effect ofTricyclic Antidepressants on the Turnover of Acetylcholine in the Brain,"under the supervision of Dr. Angelos E.Halaris, Assistant Professor in the Departments of Psychiatry and BehavioralSciences (Biopsychology).Medical Study in lithuaniaLinas A. Sidrys, who received his M.D.degree from the Pritzker School ofMedicine last June, spent the last threemonths of his senior year studying in theLithuanian Republic of the U .S.S. R.Sidrys is the son of Dr. Rimvydas Sidrys, a Streator, Illinois ophthalmologist,and Dr. Giedra Sidrys. Like his parents,who came to the United States afterWorld War II, he speaks fluent Lithuanian.It required a year and a half of paperwork by the Pritzker School of Medicineto obtain permission for Sidrys to do amedical rotation in the U.S.S.R., including a personal call by the Dean and VicePresident for the Medical Center to theU.S.S.R. Academy of Sciences in Moscow.Sidrys spent most of his three-monthstay at the University of Vilnius MedicalSchool, after a week of visits to government offices to obtain permission towork in the University's hospital. Hespent a month in internal medicine, threeweeks in cardiac surgery, two weeks ingeneral surgery, and two weeks inophthalmology.He served under Dr. Algimantas Marcinkevicius, a renowned cardiac surgeon. The Vilnius cardiac service reportedly has the best cardiac bypass results in the U. S. S. R. Sidrys actuallyserved as an intern, taking part in heartoperations as the third surgeon.He spent the final week of his visit toLithuania in the brand-new 240-bedKaunas Eye Hospital, which was openedin 1976. He reports he was the firstforeigner since World War II to be permitted to live in Kaunas.Medical studies in Lithuania begin atabout age 18, after the equivalent of U.S.high school, and take up to six years,followed by the internship, now knownin the U.S. as a first-year residency. Medical studies there stress strict discipline and rote learning more than doU.S. studies, says Sidrys. U.S. studentshave much more responsibility, being involved in hospital admission procedures,patient care, arid preparing patients forsurgery.Dr. Sidrys began his residency training in ophthalmology at the MedicalCenter in July. After three years' residency training, he hopes to enteracademic medicine.Beadle, Coggeshall ProfessorshipsHewson H. Swift, Professor in Biology,Committee on Genetics, and the College, has been appointed by PresidentJohn T. Wilson as the George WellsBeadle Distinguished Service Professor.Swift, a cell biologist who pioneered inthe use of the electron microscope tostudy genes and tissue growth, joined thefaculty as instructor in the Departmentof Zoology in 1949.He is a member of the executive council of the American Society for CellBiology and served as president in1963-64. He is also a member of the Genetics Society of America, the International Society for Cell Biology, andthe Histochemical Society.Dr. Cornelius W. Vermeulen, Professor in the Department of Surgery(Urology) and Director of Special Projects for the Medical Center, the Divisionand the Pritzker School of Medicine, hasbeen named the Lowell T. CoggeshallProfessor of Medical Sciences at theUniversity by President John Wilson.He received his M.D. degree from theUniversity in 1937, served his internshipand residency here, and joined the faculty in 1941 as instructor in the Department of Surgery. He is internationallyknown for his research on stone formation in the urinary tract.Guillery Appointed ProfessorR. W. Guillery has been appointed Professor in the Department of Pharmacological and Physiological Sciences andin the Division of Biological Sciences atthe University of Chicago.He will head a new interdisciplinaryprogram in neurobiology, part of whichwill be housed in the new six-storySurgery-Brain Research Institute Building now under construction. The programwill concentrate on such problems as themechanisms that control neural development and the organization of adult sensory pathways.An internationally known specialist in31visual pathways in the central nervoussystem, Guillery was Professor in theDepartment of Anatomy at the University of Wisconsin Medical School, Madison.Dr. Alfred Heller, Professor andChairman of Pharmacological and Physiological Sciences, commented, "Professor Guillery has performed classicstudies on nerve pathways of the forebrain and hypothalamus and, in recentyears, on congenital abnormalities of thecentral visual pathways in the brain. Thisresearch has required both neuroanatomic and neurophysiological methods. He will playa major role in the development of departmental as well as divisional programs in neurobiology."Guillery, a British citizen, was born inGermany and received the B.Sc. degree(1951) and the Ph.D. (1954) in anatomyfrom London University. He held teaching and research positions at UniversityCollege, the University of London, andWisconsin. He was named professor atWisconsin in 1968.He is the author and coauthor ofnumerous published research reports onneural development, visual pathways, thestructures of nerve cell endings, andnerve degeneration.Beck Appointed Director of FMIRobert N. Beck has been named Director of the Franklin McLean MemorialResearch Institute at the University ofChicago. He is Professor in the Department of Radiology and the McLean Institute, Director of the University ofChicago Center for Radiologic ImageResearch, and Director of the Section ofRadiological Sciences in the Departmentof Radiology.Beck, an expert in nuclear medicine,helped develop radioactive technetiumscanning, now widely used in U.S. hospitals and around the world to detectlung embolisms, and in other nuclear imaging procedures and devices.He is the author and coauthor of over100 published research reports on nuclear imaging and is coeditor of Fund amental Problems in Scanning (1968),Radiation Prot e ct io n : The Role ofSemiconductor Detectors ill the Fut ure ofNuclear Medicine (1971), and Methodsfor Evaluating Radionuclid Imaging Proc edures (in preparation).Beck succeeds Dr. Leon O. Jacobson,who organized the Institute as the Argonne Cancer Research Hospital andserved as its Director from 1951 to 1967.Dr. Jacobson returned as director of theInstitute in 1974. He will continue toserve as the Joseph Regenstein Professor of Biological and Medical Sci-32 Robert Beckences in the McLean Institute and theCollege, performing research and seeingpatients on a full-time basis.Tripathi Joins OphthalmologyDr. Ramesh C. Tripathi has been appointed Professor in the Department ofOphthalmology. He was formerly SeniorLecturer in the Institute of Ophthalmology in the University of London Facultyof Medicine, and is Executive Editor ofExperimental Eye Research (London).The appointment was made by President John T. Wilson, on the recommendation of D. Gale Johnson, Provost,and Robert Uretz, Acting Dean of theDivision of the Biological Sciences andthe Pritzker School of Medicine and Acting Vice President for the Medical Center.Tripathi, a British citizen, is a nativeof India. He received his medical education in I ndia and Great Britain and hasheld various teaching and research positions in both countries.He is a specialist in the use of the electron microscope for the study of eye diseases and is the author and coauthor ofpublished research reports on hypertensive retinopathy, diabetic retinopathy,venous occlusion, glaucoma, cerebrospinal fluid drainage, and diseases of thecornea, uvea, lens, and vitreous humor.He is married to the former BrendaJennifer Lane, who has been appointedResearch Associate (Assistant Professor) in the Department of Ophthalmology. She was Lecturer in Pathologyat the Institute of Ophthalmology, and isalso the author and coauthor of numerous research papers, including severalwith her husband. Test Predicts Fate of Comatose PatientsThe prime question in the minds of thephysicians and families of comatose patients usually is: Will they survive?Dr. Jack de la Torre, a University ofChicago neurobiologist, has developed anew test that has successfully predictedthe outcome in fifteen comatose patientswho suffered severe head injuries. Thetest, which measures "evoked" nervesignals received in the so-called sensorycortex of the brain, correctly predictedfull or partial recovery in three comatosepatients and non-recovery (death) intwelve. The signals were induced in thewrists or knees.Fifteen patients both sexes aged 3 to72 who had been in a coma from 3 to 93days received the test. All had "close"head injuries in which the skull was notfractured or penetrated. All had some"brain wave" (EEG) acti vity but couldnot be aroused by external stimulation.This is the first known use of the sensory evoked response technique to predict the outcome of coma following severe "close" head injury. Neurologistsand psychologists have used the technique experimentally and clinically forsome years to study nerve and brain action."The combination of sensory, visual,and auditory evoked responses can nowoffer the clinician an assessment of thefunctional integrity of three diverseneural pathways," says de la Torre.The test predicts only recovery fromcoma, says de la Torre, not the extent ofpossible disability after recovery. Hesays that the technique is probably anextremely reliable index for the outcomein such patients, but warns that before afinal judgment of its usefulness is made,many more clinical case studies must beperformed.De la Torre is Associate Professor inthe University of Chicago Brain Research Institute and in the Departmentsof Surgery (Neurosurgery) and Psychiatry. He has also administered the test tovictims of other neurological disorders,including brain and spinal cord traumafrom accidents, multiple sclerosis andParkinsonism.New Substance Treats Drug AddictionA new heroin substitute has been foundto be superior to methadone in severalrespects for treating drug addiction. Drs.Edward C. Senay, Walter Dorus, andPierre F. Renault found that methadylacetate, a methadone analog, is as effective as methadone in narcotic substitution therapy.Methadyl acetate has several advantages over methadone:·It need only be administered threetimes a week, versus seven times a weekfor methadone.• No weekend dose is given the addictfor self-administration, as with methadone, making it impossible to sell it tobuy heroin.The methadone substitute has somedisadvantages:.It is more difficult to establish somepatients on maintenance doses ofmethadyl acetate. Some patients maytolerate methadone better.• Because of differences in patient toleration, more methadyl acetate patientsmay drop out of a maintenance program.Senay and his colleagues suggest thatsome drug abusers may have a compulsive need for daily treatments."Methadyl acetate may be the drug ofchoice for patients with relatively goodpsychosocial adjustment," they reportedin lAMA, the Journal of the AmericanMedical Association. "A patient whogives a history of continuing heroin usebased on his need to avoid withdrawalsymptoms rather than on a psychologically based need for pharmacologicalsupport and tranquilization might be better started on methadyl acetate treatment. Patients with evidence of a psychological need to use drugs compulsively and those without employment orstable outside social supports might bebest considered for methadone maintenance. "Some patients, they suggest, might bestabilized on methadone and laterswitched to methadyl acetate.Dr. Senay is Professor in the Department of Psychiatry, and was Director ofthe Illinois Drug Abuse Program(lDAP), from which the patients in thestudy were recruited. Dr. Dorus is Research Associate (Assistant Professor)in Psychiatry and was Research Directorof IDAP. Dr. Renault was AssistantProfessor in Psychiatry and is now in theDivision of Research of the National Institute on Drug Abuse.Pure Erythropoietin SampleU sing urine specimens, University ofChicago scientists have obtained a puresample of erythropoietin, a hormone thatstimulates production of red blood cells.The sample of human erythropoietin iseight times more active than previouslyreported pure sheep erythropoietin samples. It will make it possible to start adetailed study of erythropoietin's chemical and biological properties, saysCharles K. -H. Kung, senior scientist inthe Franklin McLean Memorial Research Institute.If the chemical structure of erythropoietin can be discovered, a means Dr. Edward Senaymay be found to create synthetic erythropoietin to treat anemia, in whichthere is reduced ability of the blood tocarry oxygen to the tissues.When there is a need for increased redblood cells to deliver oxygen to tissue,the body normally increases the amountof circulating erythropoietin. The hormone then "instructs" the bloodforming tissue (mainly in the bone marrow) to increase the production of redblood cells.Erythropoietin is formed principally inthe kidneys of humans and other mammals. Some victims of kidney disease areunable to produce their own body erythropoietin and require careful management and occasional blood transfusions.If enough pure hormone or syntheticerythropoietin were available, it mightfacilitate the treatment of anemia in kidney patients. At present there is notenough of the pure hormone for anytreatment purposes.How erythropoietin acts to form redblood cells from progenitor cells wouldbe useful in the study of biological differentiation. With erythropoietin available,this process can now be studied in progenitor cell cultures in the laboratory.Knowledge of differentiation, both normal and abnormal, is needed to under'stand how cancer and birth defects andother diseases may occur. Much morepure hormone will be needed before thestructure of erythropoietin is finallyestablished, says Kung.Urine from specific kinds of patients isat present the only practical source oferythropoietin. The best source for research purposes is the urine of aplasticanemia patients. This disease is characterized by a severe deficiency of red blood cells. A substantial portion of theerythropoietin in aplastic anemia patients spills over into the urine and is excreted .Coauthors with Kung of a paper onthis research are Dr. Takaji Miyake ofKumamoto University Medical School,Japan, and Eugene Goldwasser, Professor in the Department of Biochemistry, the McLean Institute, and theundergraduate College at the Universityof Chicago.Measuring DES Cancer RiskThe risk of vaginal or cervical cancer inyoung women associated with fetal exposure to DES (diethylstilbestrol, a synthetic estrogen) taken by the mothersduring pregnancy in the 1950s is about Iin 1,000 at most, according to Dr. ArthurL. Herbst, the Joseph Bolivar De LeeProfessor and Chairman in the Department of Obstetrics and Gynecology andChief of Staff of Chicago Lying-in Hospital. The odds can extend to about 1 in10,000 at the least. The difference relatesto lack of knowledge concerning howmany pregnant women took DES.Herbst theorizes that DES was one ofseveral factors that in combination mayhave caused such cancers.Herbst based the estimates on a studyof 154 DES-associated cases of suchcancers and on the estimate, based inpart on U.S. census birth statistics, thatfrom 1 to 10 percent of pregnant womenin the United States received DES in theyears 1951 to 1969.Coauthors of the paper were Dr.Philip Cole, epidemiologist at the Harvard School of Public Health; Dr. Theodore Colton, statistician, DartmouthMedical School; and Dr. Stanley Robboy and Dr. Robert F. Scully, of theDepartment of Pathology, Harvard University and Massachusetts GeneralHospital.Evaluating X-ray DiagnosisA World War II technique to determinethe effectiveness of radar detection isbeing studied here as a means to judgethe diagnostic effectiveness of X-ray andnuclear imaging. The technique, knownas an ROC (receiver operating characteristic) curve, has also been used bypsychologists in studies of auditory andvisual signals.It could be used to determine whethernew types of X-ray brain and body scanners (computerized axial tomography)and ultrasound imaging techniques areworth the large slims of money paid forthem by hospitals.Charles E. Metz, Associate Professorin the Department of Radiology and theFranklin· McLean Memorial Research33Institute, recently described his theoretical and experimental research on themedical applicability of the technique.The ROC curve, as Metz proposes touse it in judging the effectiveness ofX-ray and nuclear-imaging diagnoses,charts on a graph the relationship between the frequencies of correct and incorrect positive diagnoses at various socalled "decision threshold" levels."Some diagnosticians will use a strictthreshold-they will diagnose as abnormal only those cases in which they areabsolutely certain that disease is present," says Metz. "They will have a highratio of correct negative decisions butwill miss some positive cases that a lesscautious radiological diagnosticianwould correctly diagnose."The ROC curve can be charted inhuman cases by comparing the actual diagnoses made in humans to results obtained by surgery and pathologicalexamination.To date, Metz and his colleagues, Dr.Lee B. Lusted, Professor and FacultySecretary in Radiology, and Stuart J.Starr, a graduate student in Radiology,have only tested the ability of Universityradiologists and medical physicists to detect test objects in X-rays and in computerized radionuclide images on videoscreens. They soon hope to test themethod on cancer patients."With the increased cost of variousdiagnostic procedures, there is an increased need for methods to demonstratewhether the expense of new equipment isjustified by the benefits," says Metz.ROC analysis is a method of measuring and describing the detectability ofsignals against a background of "noise"or irrelevant image features.Each individual diagnostician has hisown "decision threshold" at which hedetermines that a significant image (or"blip" on a radar screen) is present-s-orappears to be present.The object is to chart the performanceof a variety of diagnosticians withspecific radiological or nuclear imagingequipment. Possible trade-offs in improved diagnosis can be revealed if thediagnostician alters his "confidencethreshold. "Surgery Repairs Ruptured SpleenThe spleen is one of the most frequentlyinjured of organs, and is normally removed after rupturing in a fall, auto accident or fight.But total removal-splenectomy-isnot always necessary. Dr. John Burrington, a University of Chicago pediatric surgeon, has reported successful surgical repair-rather than removal-ofeight of ten ruptured spleens in children.34 All of the children recovered withoutsubsequent infection or illness. In two ofthe ten cases, the patient's spleens wereremoved because of associated injury tothe pancreas.It is possible for most adults to livewithout spleens, but infants and youngchildren are highly susceptible to infection after splenectomy. The juvenilemortality is much higher. It is nowthought that an intact spleen helps produce such defenses against disease aswhite blood cells and opsonins (antibodies that render bacteria and damagedred blood cells susceptible to ingestionand digestion by white blood cells knownas phagocytes).Of the ten children upon whom Burrington operated, five were victims ofauto accidents, three were injured infalls, one was injured in a sledding accident, and one was a suspected victim ofchild abuse.Damaged and dead tissue resultingfrom cracks and tears was removed fromthe spleens of six of the patients, and thespleen sutured. Torn-away material wasremoved from the spleens in two victimsand the wound sutured. In six of the tenpatients, the spleen was still bleedingwhen exposed.Burrington favors careful abdominalexploration to observe the extent ofdamage to the spleen and the possibilityof associated injuries. The surgical techniques widely used to preserve damagedliver and kidney tissue are equally applicable to spleen tissue, he says.Burrington is Professor and Head ofthe Section of Pediatric Surgery in theDepartment of Surgery and Wyler Children's Hospital.Brain Cell Maturation FactorDr. Ramon Lim, a physician andbiochemist in the University of ChicagoBrain Research Institute, has reporteddiscovery of a protein that promotesmaturation in a type of embryonic braincell known as glial cells. He has observed its effect on rat brain cells underthe microscope. A similar maturationfactor presumably exists in humans.The discovery presents several significant aspects:.Mental retardation: Retardation isdue to inadequate development of braincells; some type of the disease is possiblydue to a lack of glia maturation factor. Ifso, the patient might benefit from administration of the factor..Brain tumors: The majority of braintumors are caused by the uncontrolledgrowth of the glial cells resulting fromreversion of the mature glia to the undifferentiated primitive predecessorcells. Lim infers that lack of the factor This patient room in the new eight-bed acuteintensive care section of the University's BumCenter is equipped with heat lamps and a builtin monitoring console. Color television andvibrantly-colored walls combat sensory deprivation during long periods of hospitalization.An open house for the new Center was held onJune 6.may permit normal glial cells to revert toa more primitive state, forming glial-typecancer cells. "Glia maturation factormight enhance the maturation of theseprimitive-type cancer cells, thus slowingdown or arresting tumor growth," hesays..Head injury: In cases of brain damage from head injury, there is usually anexcessive growth of differentiated glialcells as part of the repair mechanism ofbrain tissue, a condition known as gliosis(formation of glial scar). It is possiblethat when neurons are injured they release the glia maturation factor, whichtriggers gliosis. Gliosis can lead to longterm effects on the brain, such asepilepsy. In this case, unlike the case ofbrain tumors, says Lim, the appropriateremedy would be to inhibit the development of glial cells. "We hope to reducethe extent of gliosis by administering anantiserum against glia maturation factorwhich we hope to develop," he says.Lim cautioned that he and his colleagues have not conducted any tests onhumans, and" any use for humans at thisstage is only speculative."Lim is Associate Professor in the Departments of Surgery (Neurosurgery)and Biochemistry. His colleagues in thisresearch are David E. Turriff andShuang S. Troy, Research AssociatesDr. Ramon Lim(Assistant Professors) in the Departmentof Surgery (Neurosurgery).The glia maturation factor that theydiscovered is a large molecule present inthe adult brain but found only in smallquantity in the embryonic brain andbrain tumor."Although a similar factor for neuronshas been detected before," says Lim,"this is the first instance where a proteinthat can stimulate the glial cells to differentiate has been found. We believe thatthe glia maturation factor exerts' its effectby promoting the glial cells to communicate with one another, a process important in cell differentiation. The loss ofthis factor may result in the lack of communication between the glial cells, whichin tum may lead to the underdevelopment of the brain. Conversely, the lackof communication may lead to the uncontrolled growth of the undifferentiatedcells-the formation of tumors. It isworth noting that almost all tumors arising from the brain come from the glialcells. "In MemoriamRichard W. Reilly, 1926-1977Dr. Richard W. Reilly, Professor ofMedicine at the University of Chicago,died at his home in Crete, Illinois onMay 30 after a long illness. He was 51.Reilly was a specialist in gastrointestinal disease. He organized an international conference at the University ofChicago in 1974 on Fiber DeficiencyDisorders of the Colon. He was coeditorof Fiber Deficiency and Colonic Disorders (1975), the proceedings of theconference, and was author andcoauthor of numerous other publicationson gastrointestinal disease. A native of Chicago, Reilly receivedhis Ph.B. (1948), B.S. (1950), and M.D.(1953) degrees from the University ofChicago. After internship at KingCounty Hospital in Seattle, he was ingeneral practice at Cedar Lake, Indianafor several years before returning to theUniversity as a Resident in Medicine.He was appointed Instructor inMedicine in 1960, Assistant Professor,1962, Associate Professor, 1966, andProfessor, 1974.Dr. Reilly is survived by his wife, theformer Marian Keen, and three children,Phillip, Gwenyth, and Hugh; and by hisfather, Arthur P., and brother, A. Paul.Memorial gifts may be made to theRichard W. Reilly, M.D., MemorialFund in care of the Department ofMedicine, University of Chicago Medical Center, 950 E. 59th Street, Chicago,Illinois, 60637.Alumni Deaths, 10. David D. Todd, La Jolla, California, November 4, 1976, age 93., 11. Edmund J. Burke, La Salle , Illinois, May 27, 1977, age 89.'12. Thomas C. Galloway, Jr.,Evanston, Illinois, February 24, 1977,age 90.'12.John R. Newman, Madison, Wisconsin, October 10, 1976, age 89.'13. Frank K. Bartlett, Sr., Ogden,Utah, October 11, 1976, age 89.'13. Hobart R. Hunter, Glendora,California, September 18, 1976, age 92.'15. Jay H. McCormack, Seattle,Washington, November 21, 1976, age 91.'15. Benjamin Rappaport, Wadsworth,Illinois, May 3, 1977, age 86.'16. Henry H. Cox, LaSalle, Illinois,December 6, 1976, age 85.'18. Marion Cole-Schroeder, Miami,Florida, March 6, 1977, age 83.'19. Richard C. Gamble, Sedona,Arizona, December 23, 1976, age 81.'19. David M. Levy, New York, NewYork, March 1, 1977, age 85.'19. Bernhard R. Reinertsen, LosAltos, California, March 10, 1976, age82.'20. John L. Calene, Aberdeen, SouthDakota, October 4, 1976, age 81.'20. Frank 1. Ratty, EI Cajon, California, May 1977, age 74.'20. Herbert C. Schlosser, Elkhart,Indiana, January 20, 1977, age 82.'20. Mandel Sherman, Los Angeles,California, February 11, 1977, age 81.'21. Frank B. Leffert, Centerville,Iowa, September 12, 1976, age 83.'21. Byron Nixon, Farmland, Indiana,September 23, 1976, age 79. '21. Melvin B. Peterson, Asheville,North Carolina, December 6, 1976, age82.'23. Julio Paez, San Diego, California,February 25, 1976, age 78.'24. Heyworth N. Sanford, New Haven, Connecticut, February 10, 1977,age 83.'27. George B. Stericker, Springfield,Illinois, July 17, 1976, age 81.'29. Clarence E. Baumle, Monroe,Wisconsin, September 22, 1976, age 73.'33. Irving M. Cobin, Joliet, Illinois,March 7, 1977, age 71.'33. Herbert 1. Levin, Donora, Pennsylvania, January 27, 1976, age 68.'34. Rudolph P. Leyers, Chicago, Illinois, December 1, 1977, age 69.'34. Carl Steckler, Richmond Hill,New York, February 7, 1977, age 70.'34. W. N. Wiborg, Chicago, Illinois,October 30, 1976, age 76.'36. Carl L. Mauser, Oakland,California, July 5, 1976, age 71.'37. Leon B. Comroe, Los Angeles,California, April 2, 1976, age 64.'37. Samuel Garrick, Chicago, Illinois, August 8, 1977, age 64.'37. Alf T. Haerem, Redwood City,California, February 15, 1975, age 63.'37. Thomas W. Reul, Watertown,South Dakota, May 12, 1977, age 67.'39. George Hartley, Jr., La Jolla,California, April 19, 1977, age 70.'40. William D. Sicher, New York,New York, January 7, 1977, age 62.'46. Earl A. Hathaway, Elmhurst, Illinois, June 12, 1977, age 54.'49. James L. Tyson, Big Rapids,Michigan, April 6, 1977, age 56.'53. Richard W. Reilly, Crete, Illinois,May 30, 1977, age 52.'54. Victor W. Smith, MenomoneeFalls, Wisconsin, June 14, 1976, age 49.'62. Robert Sabina, Munster, Indiana,August 31,1976, age 42.Former StaffJoseph S. Costa (Medicine, Intern,, 54), Arlington, Virginia, February 21,1977, age 49.Allan B. Crunde n (Obstetrics andGynecology, Resident, '41), Bel Air,Massachusetts, October 10, 1976, age65.Ernst H. Dreyfuss (Pediatrics, Resident, '46-'47), Chicago, Illinois, August7, 1976, age 66.E. Edwin Fahringer (Psychiatry, Resident, '76), Chicago, Illinois, January 30,1977, age 30.Sheldon A, Feldman (Pathology, Resident, '67-'71), Elkton, Virginia, July 6,1975, age 33.Abraham Prostkoff (Obstetrics andGynecology, Resident, '37-'38), Brooklyn, New York, March 17, 1977, age 70.35Departmental NewsAnatomyPromotion:Leonard B. Radinsky, Ph.D.-ActingChairman.J. E. McArdle, R. German, and Dr.Charles E. Oxnard presented a paper entitled, "Functional Morphometries inthe Prosimian Hip and Thigh" at the46th annual meeting of the American Association of Physical Anthropologists,held April 13-16 in Seattle. Dr. Oxnardis a Professor in the Departments ofAnatomy, Anthropology, the Committeeon Evolutionary Biology, and the College.At the same meeting Dr. RonaldSinger, the Robert R. Bensley Professorin Biology and Medical Sciences, servedas chairman of a session on primates.Dr. Singer was appointed a life trusteeand chairman of the Scientific and Educational Advisory Committee ofBrookfield Zoo in Chicago.The following faculty and studentspresented papers and poster sessions atthe 90th annual meeting of the AmericanAssociation of Anatomists in Detroit,May 1-5: Carey D. Balaban, Robert P.Becker, P. P. H. De Bruyn, Sonia Michelson, E. S. Kane, A. Nakamura, F. J.Manasek, W. Todd Rainey, Shuang Troy,P. S. Ulinski, and Y. C. Wong. Dr. Manasek , Associate Professor, was chairmanof the session on the cardiovascular system.Robert P. Becker, instructor, was appointed advisor to the 10th AnnualScanning Electron Microscopy Symposium held in Chicago March 28-April 1.AnesthesiologyA ppointment s:Dr. Charley Berona-Instructor.Dr. Howard Hahn-Instructor.Dr. Henry S. Lim-Associate Professor.Dr. Douglas E. Mayfield-AssistantProfessor.Dr. Steven Pugh-Assistant Professor.Ben May LaboratoryElwood Jensen, Professor in the Department of Biophysics and TheoreticalBiology and Director of the Ben MayLaboratory for Cancer Research, spokeon "Hormone Dependency of BreastCancer" at a May 26 symposium sponsored by Memorial Sloan-KetteringCancer Center to mark the dedication ofthe Arnold and Marie Schwartz Inter-36 national Hall of Science for Cancer Research. He has been appointed a newmember of the Advisory Council of theNational I nstitute of Child Health andHuman Development.BiochemistryPromotions:Nicholas R. Cozzarelli, Ph.D.Professor.Dr. Theodore L. Steck-Professor.BiologyPromotions:Terence E. Martin, Ph.D.-AssociateProfessor.Arnold Ravin, Ph. D.-Acting Chairman.Virginia Maiorana, Research Associate,has reported that a California salamander, to regenerate a lost tail, must useresources that would otherwise be directed to reproduction. Her experimentshave shown that, when tailless, thisspecies breeds less, both in the wild andin the laboratory, then when it has its tailintact.Aron A. Moscona, the Louis BlockProfessor in Biology, Pathology, theCollege, and the Committees on Genetics, Developmental Biology, and Immunology, was elected a member of theNational Academy of Sciences. Thisbrings to 52 the number of N AS members at the University. Dr. Moscona wasthe main speaker at the Midwestern Regional Conference on DevelopmentalBiology at Michigan State University onApril 8. He spoke on .. An Embryologist's View of the Cell Surface."Arnold Ravin, the Addie Clark Harding Professor in the Departments ofBiology and Microbiology and in theCollege, and Acting Chairman of Biology, has been a participant in the SigmaXi Bicentennial Lecture series on "Science and Society" since 1975. InNovember he will lecture on "ChangingViews of Science and Progress" at colleges in Nebraska and Wisconsin.Biophysics and Theoretical BiologyAppointment:Robert Josephs, Ph. D.-AssociateProfessor.Promotion:Thomas Nagylaki-Associate Professor.Dr. Humberto Fernandez-Moran, the A.N. Pritzker Professor, spoke at the University of Houston in April. His lectureat the Clear Lake City campus, on"Windows on Latin America," dealtwith the use of NASA's A TS-6 satelliteto transmit medical information between the United States, Venezuela, andBrazil.On May 4 Dr. Fernandez-Moran delivered the Simon Bolivar Lecture, onthe subject of "Science in theAmericas," before a meeting of theAmerican Psychiatric Association in Toronto. On May 15 he delivered the commencement address at Milton College inWisconsin and received the Doctor ofHumane Letters degree.Stuart A. Rice, Professor in the Department of Biophysics and TheoreticalBiology and in the College, and Chairman of and Professor in the Departmentof Chemistry, was named the Frank P.Hixon Distinguished Service Professorat the University.Emergency MedicineSeveral faculty members participated inthe State Scientific Assembly sponsoredby the Illinois Chapter of the AmericanCollege of Emergency Physicians onApril 14-16. Those from the Department of Emergency Medicine included:Dr. Peter Rosen, Professor; Dr. Frank J.Baker, II, Assistant Professor and Acting Chairman; Dr. Robert Rothstein,Resident; Dr. Joseph Bremer, ClinicalAssociate: and Dr. George Sternbach,Assistant Professor. Dr. Sternbach andDr. Rosen published a book entitledEmergency Medicine, Case Studies1974 -1976, in April.La RabidaAppointment:Dr. Rosa Ong-Instructor.Promotions:Dr. Jose Quintans-Assistant Professor.Medicine:Appointments:Dr. Jacob Bitran-I nstructor/Trainee.Dr. William Fennell-Instructor.Dr. Michael Field-Professor.Dr. William Fox-Assistant Professor.Dr. Jonathan Jaspan-Instructor.Dr. Eric P. Lester (,72)-lnstructorlTrainee.Dr. Alfred C. Nolan-Assistant Professor.Dr. James Stewart Reed, Jr.I nstructor/Trainee.Promotions:Victor Fang, Ph.D.-Associate Professor.Dr. Samuel Refetoff-Professor.Dr. Carol Richman-Assistant Professor.Dr. Janet Rowley (,49)-Professor.The following presented invited papersat the national meeting of the AmericanFederation for Clinical Research inWashington, D.C., April 30 -May 2:Dr. Anthony F. Cutilletta, Assistant Professor of Pediatrics (Cardiology), spokeon "Cardiac Muscle and Non-muscleCell Ribonucleic Acid Polymerase Activities during Myocardial Hypertrophy;" Dr. G. Jeelani Dhar, Fellow inMedicine (Gastroenterology), spoke on"Direct in vivo Demonstration of theSequence of Events in Intestinal Polyglutamyl Folate Absorption;" and Dr.K. Soltani, Assistant Professor (Dermatology), spoke on "Detection ofHuman Alpha-Fetoprotein (HAFP) inthe Epidermal Cells of Bowen's Disease."Dr. Leslie J. DeGroot, Professor in theDepartments of Medicine and Radiology, and Dr. Edwin Kaplan, Professor inthe Department of Surgery, spoke on"Hyperthyroidism" at a continuing medical education program at CommunityHospital in Geneva, May II.Dr. Sumner C. Kraft ('55), Professorin the Department of Medicine, has beennamed the 1977 recipient of the WilliamBeaumont Award for Clinical Research.He received the award at the Sixth Annual Beaumont Gastrointestinal Symposium, held in El Paso, Texas, March23-25.Dr. Richard L. Landau, Professor inthe Department of Medicine and Chairman of the Clinical Investigation Committee, was the featured speaker at aMarch 23 meeting of the Chicago Chapter of the American Medical Writers Association, where he discussed "Why SoFew Really New Drugs?"Dr. Walter L. Palmer, the Richard T.Crane Professor Emeritus, participatedin a memorial to Dr. Morris Fishbeinpresented by the Society of Medical History of Chicago on April 20.Dr. John Ultmann, Director of theCancer Research Center and Professorin the Department of Medicine, servedas a visiting professor at the Departmentof Medicine and Section of Medical Oncology at Yale University in April. Hespoke on "Twenty-five Years of Progress in the Management of Hodgkin'sDisease," and also conducted grandrounds and three conferences.MicrobiologyAppointments:Rosann Farber, Ph. D.-AssistantProfessor.Thomas Petes, Ph.D.-Assistant Professor. NeurologyPromotion:Dr. Lawrence P. Bernstein ('70)Assistant Professor.Obstetrics and GynecologyAppointment:Dr. Donald Tredway-Associate Professor.Dr. Marshall D. Lindheimer, Professor inthe Departments of Obstetrics andGynecology and Medicine, is currentlyon sabbatical as visiting professor andsenior international fellow (N I H) at theUniversity of Geneva, Switzerland.While abroad, he has lectured in Paris atthe Hopital Tenon and Hopital Neckar,on sodium levels and diuretics in pregnancy.At the annual Chicago Lying-in Hospital Board of Directors' Dinner held inChicago on May 25, Dr. Edith Potter,Professor Emeritus and world-renownedauthority on infant pathology and fetaldevelopment, was presented with theJoseph Bolivar De Lee HumanitarianAward.OphthalmologyAppointment:Dr. Ramesh Tripathi-Professor.The Alex E. Krill Memorial Conference,which will be held October 21-22 at theDrake Hotel in Chicago, will include lectures by speakers from the Department.Further information may be obtainedfrom Dr. Frederick A. Mausolf, Department of Ophthalmology, Universityof Chicago, 950 East 59th Street,Chicago, Illinois 60637.Dr. Peter H. Morse, Associate Professor, spoke on "Encirclement versus3600 Buckling and Prognostic Factors inRetinal Separation Surgery" at the 97thAnnual Congress of the Ophthalmological Society of the United Kingdom, heldat the University of Bath, England, onApril 13.Dr. Frank W. Newell, the James N.and Anna L. Raymond Professor andChairman of the Department, was reelected vice president of the NationalSociety for the Prevention of Blindnessat the Society's annual meeting on May19. Dr. Newell is also chairman or theSociety's Committee on Basic and Clinical Research.PathologyAppointment:Dr. Nelson Ordonez-Assistant Professor.Dr. Robert Riddell-Assistant Professor.Dr. Hans Schreiber-Assistant Professor. Promotion:Dr. Andrew Churg (,73)-AssistantProfessor.Dr. James E. Bowman, Professor in theDepartments of Pathology andMedicine, Director of Laboratories, andMedical Director of the Blood Bank forthe Medical Center, has been chosen aNational Lecturer of Sigma Xi for1977-78.PediatricsAppointments:Dr. Robert R. Chilcote-AssistantProfessor.Dr. Barbara Kirschner-AssistantProfessor.Dr. Marvin Zelkowitz-AssistantProfessor.Promotions:Dr. Jay E. Berkelhamer-AssociateProfessor.Martin B. Mathews, Ph.D.Professor Emeritus.Dr. Anne Lucky, Assistant Professor,participated in pediatric grand rounds atLittle Company of Mary Hospital,Evergreen Park, lllinois, on April 21.Dr. Robert Rosenfield, Associate Professor, spoke on "Hormonal Events andDisorders of Puberty" at the Roundtableon Pediatric Endocrinology sponsoredby the Department of Pediatrics ofLoyola University Medical Center onMarch 30.Dr. Samuel Spector, Professor andChairman of the Department, was theguest of the Tod Babies' and Children'sHospital of Youngstown, Ohio, on April14, which was celebrating its 50th anniversary. He conducted teachingrounds at the hospital and was lecturer atgrand rounds at the Youngstown Hospital Association.The Wyler outpatient clinics are thesubject of a chapter entitled "TheRoberts Team" in a new nursingtextbook, Together: A Casebook ofJoint Practices in Primary Care. Thechapter describes the Wyler team approach to general pediatric ambulatorycare. Each team consists of a pediatrician, residents, one or more pediatricnurse associates, and a social worker.Arrangements with special consultantssuch as a speech therapist or an orthopedic surgeon are made in the specialty clinic on the suggestion of amember of the team. Dr. Jay Berkelhamer, Associate Professor, is Director of Ambulatory Pediatrics..Pharmacological and Physiological SciencesAppointment:Rainier GuiLlery, Ph.D.-Professor.37Promotion:Lewis S. Seiden, Ph.D.('62)Professor.Dwight J. Ingle, Professor Emeritus,participated in a memorial to Dr. MorrisFishbein presented by the Society ofMedical History of Chicago on April 20.PsychiatryAppointments:Dr. Michael Fauman (,74)-AssistantProfessor.Dr. William Matuzas-InstructorlFellow.Dr. William W. WeddingtonAssistant Professor.Promotion:Dr. Edward C. Senay-Professor.Dr. Daniel X. Freedman, Chairman andthe Louis Block Professor in the Department of Psychiatry, spoke at theApril 30 annual banquet of the Societyfor Biological Psychiatry in Toronto on"Ideologies and Teratologies in Psychiatry." Scientific papers were also presented by Dr. John M. Davis, Professor,and Dr. Carol Tamminga, Instructor andFellow.Dr. Freedman delivered the annuallecture at Dartmouth Medical School on"The Future of American Medicine:Crisis or Lysis?" He also served withformer Department of Health, Education and Welfare Secretary, John Gardner, on the selection committee tochoose the President's Commission onMental Health.Dr. Herbert Y. Meltzer, Professor,presented three papers at the AmericanPsychiatric Association's annual meeting in Toronto on May 4. The paperswere entitled: "Neuroendocrine Strategy in Schizophrenia," "Recent Developments in the Biochemistry of Schizophrenia," and "Platelet and PlasmaMonoamine Oxidase in Schizophrenia."He also presented the first paper at theSociety for Biological Psychiatry's annual meeting on April 30.RadiologyAppointments:Dr. Brent M. Greenberg-Instructor.Dr. Karim Rezai-Zadeh-InstructorlTrainee.Dr. Bhurji N. Singh-Instructor.Promotions:Dr. T. McDowell Anderson, Jr.Assistant Professor.Dr. Maria Bouzouki-Assistant Professor.Dr. Kunio Doi-Professor.Dr. Paul H. Frank-Assistant Professor.Lester S. Skaggs, Ph. D. ('39)Professor Emeritus.38 SurgeryAppointments:Dr. Ernest E. Mhoon, Jr. ('73)Assistant Professor.Dr. Steven Rubin-Assistant Professor.Promotions:Dr. Warren Enker-Associate Professor.Dr. John J. Lamberti-Associate Professor.Dr. Martin Robson-Professor.Dr. John D. Burrington, Professor andHead of the Section of PediatricSurgery, spoke on "Initial Managementof Children with Multiple Injuries" atthe Illinois American College ofEmergency Physicians/Emergency Department Nurses Association CombinedScientific Assembly on April 14.Dr. A. R. Moossa, Associate Professor, delivered the Hunterian Lectureto the Royal College of Surgeons of England in London on April 13. His subjectwas "Investigative Approaches to theProblem of Pancreatic Cancer." DuringJuly and early August Dr. Moossa willbe a visiting professor at universities inEngland and Scotland and present special talks at the University of Oxford, theBritish Society of Surgical Research, thePancreatic Society of Great Britain, andthe British Society of Pediatric Surgery.In addition, he will serve as a member ofa panel on treatment of Crohns Diseasein childhood, at a symposium in Oslo.Dr. Moossa was recently elected to theSociety of University Surgeons.Dr. Ralph F. Naunton, Professor ofSurgery and Head of the Section ofOtolaryngology, lectured on "AuditoryImplants" at the Seventh Annual Convention of the Illinois Speech and Hearing Association on April 22. At the samemeeting, Dr. Gregory J. Matz, AssociateProfessor, and Harris J. Mowry, an audiologist, presented "ComputerizedTomography and Audiometric Findingsin Lesions Involving the Eighth Nerve."Dr. Simon J. Simonian, Assistant Professor, attended the 12th Congress of theEuropean Society for Surgical Researchin Warsaw, Poland, April 23-27. He presented a report on "Conversion of anArteriovenous Fistula from a ScribnerShunt for Immediate Vascular Accessfor Chronic Hemodialysis." He was visiting professor and guest lecturer at theDepartment of Surgery of the Universityof Cambridge Clinical School on May 2,and at the Department of Surgery of theUniversity of Stockholm on May 3.An article entitled, "ConvulsionsComplicating Colectomy in Inflammatory Bowel Disease" appeared inthe April 4 issue of the Journal of the American Medical Association. Authorsare Dr. James A. Schulak ('74), Residentin Surgery; Dr. A. R. Moossa; Dr. GeorgeE. Block, Professor; and Dr. Joseph B.Kirsner, the Louis Block DistinguishedService Professor in Medicine.Zoller Dental ClinicAppointments:Dr. Lynn Ballard-Assistant Professor.Dr. Anthony Young-Assistant Professor.Reappointments:Dr. Charles S. Greene, Clinical Associate Professor, through June 30,1978.Dr. Benjamin J. Gans, Clinical Professor, through June 30, 1978.Dr. Albert A. Dahlberg, Research Associate (Professor) in the Zoller DentalClinic and in the Department of Anthropology, recently published a bookentitled, Orofacial Growth and Development. The book is part of a series onWorld A n t h ro p ol o g y , published byMouton Publishers.Dr. Thomas M. Graber, Professor inthe Zoller Dental Clinic and the Department of Pediatrics, and ResearchAssociate (Professor) in the Departmentof Anthropology, is coeditor with Dr.Dahlberg. Dr. Graber received a meritaward for professional achievement fromthe alumni association of NorthwesternUniversity.Michael Reese-PritzkerThe following full-time members ofMichael Reese Hospital and MedicalCenter have been reappointed to thestaff of the Pritzker School of Medicine:Department of Anesthesiology:Reappointments:Dr. Roger F. Bonnet, Assistant Professor, through June 30, 1978.Dr. David J. Miletich, Assistant Professor, through June 30, 1978.Dr. Ronald Rosenberg, AssociateProfessor, through June 30, 1978.Dr. Edward T. Toyooka, AssociateProfessor, through June 30, 1978.Dr. Behrooz Zahed, Associate Professor, through June 30, 1978.Dr. Ronald F. Albrecht, Professor,through June 30, 1978.Department of Medicine:Promotions:Dr. Frederic L. Coe ('61) to Professor, effective January I, 1977.Dr. Sherwin A. Kabins to Professor,effective January 1,1977.Dr. Daniel Offer ('57), Professor of Psychiatry, has been appointed chairman ofthe Department of Psychiatry and direc-Dr. Daniel Offertorofthe Psychosomatic and PsychiatricInstitute at Michael Reese Hospital andMedical Center. Dr. Offer has been acting chairman and director since the retirement of Dr. Roy R. Grinker Sr. (,21)last July. In his new post, Dr. Offer willsupervise the outpatient, inpatient, research, and educational psychiatric programs, with a staff of 193 professionalsand trainees. Dr. Offer, an internationally known specialist in adolescentpsychiatry, is the author of six books andninety scientific articles.Division General (Emergency Room)Appointments:Dr. Jack B. Franaszek-Instructor.Dr. Robert J. Rothstein-Instructor.Promotion:Dr. Frank J. Baker, II-Acting Director, Emergency Room.Dr. George LeRoy Alumni News1915Edmund Jacobson, director of the Laboratory for Clinical Physiology inChicago, had the fifth edition of YouMust Relax published in 1976 by theMcGraw-Hill Book Company. Dr.Jacobson also has a Ph.D. in 1910 fromthe University of Chicago, where he wasa research associate and assistant professor of physiology from 1926--1936. Heis a pioneer exponent of electromyography, the use of electronic equipment todetect muscular movements by tiny electrical charges in muscles. The first edition of You Must Relax was written forthe lay public in 1929.1925Harold Henke, of Duarte, California, retired from practice in January, 1977.Samuel L. Perzik, associate professorin surgery at Lorna Linda UniversitySchool of Medicine and head of the department of head and neck surgery at theCedars-Sinai Medical Center, LosAngeles, is author of a book entitledSurgery in Thyroid Disease-The Placeof Total Thyroidectomy, published byStratton Intercontinental Medical BookCorp., New York, December 1976.1926James W. Shaw has retired after 50 yearsof general practice in Wichita, Kansas.His two sons are both physicians nowpracticing in Kansas. Dr. Richard Shawis a plastic surgeon in Wichita and Dr.James Shaw, Jr., is a pathologist inHutchinson.1934P. Le Mon Clark of Fayetteville, Arkansas, retired in 1976, and recently celebrated his 80th birthday.1935George V. LeRoy retired July I from theUniversity of Chicago after a long association. He served his residency in theDepartment of Medicine from 1935-1938; later he joined the faculty as professor of medicine from 1951-1964; andagain in 1970 he returned as director ofthe University Health Service. Dr. andMrs. Le Roys new address is 171 NorthRutledge, Box 189, Pentwater, Michigan49449.1936P. Blair Ellsworth is retired and lives inSun City, Arizona. He is a past trusteeof Kiwanis International. 1938Charlotte G. Babcock, professor of psychiatry at the University of Pittsburgh,was honored at the second annual Charlotte Babcock Symposium, held inPittsburgh, March 18-19. The Symposium was sponsored by the PittsburghPsychoanalytic Society and thePittsburgh Psychoanalytic Institute.Ralph Christenson retired last September from his position in Boise, Idaho. Heis now a consultant for the Public Service Satellite Consortium and lives inPortland, Oregon.H. Todd Stradford writes that he retired in 1973 from the University ofRochester, New York, where he was amember of the orthopedic surgery faculty. He now lives in Columbia, Missouri.1939William M. Lees of Lincolnwood, Illinoiswas elected second vice-president of theIllinois State Medical Society. Dr. Lees,a thoracic surgeon, is chief of staff atHines Veterans Administration Hospital, and a past president of the ChicagoSurgical Society and the Illinois Societyfor Medical Research. He also serves aspresident of the Illinois Council on Continuing Medical Education.1942George H. Handy of Madison, Wisconsinreceived the Civic Leadership Award ofthe Wisconsin State Medical Society.This is only the sixth time the award hasbeen given. The inscription on Dr.Handy's plaque read, "Doctor Handy'smany activities identify him as not only adedicated physician but a dedicated public servant-and most significantly, onewho practices personal involvement inthe democratic processes of this greatrepublic." Dr. Handy was in generalpractice in Wisconsin Rapids from 1947until 1964. Most recently he was administrator of the Division of Health andState Health Officer from 1971 to 1976,when he resigned to take a position withthe Cuna Mutual Insurance Company inMadison.Isadore Rossman, medical director ofthe Home Care and Extended ServicesDepartment of Montefiore Hospital, wasrecently appointed a member of the National Advisory Council on Aging. TheCouncil is responsible for advising theSecretary of the Department of Health,Education, and Welfare and the NationalI nstitute on Aging on programs relatingto the aged. This appointment is givenonly to top experts in the field of aging.Dr. Rossman is also on the Board ofDirectors of the New York City Division of the American Cancer Society.39He has written and edited numerousbooks and papers, including a book entitled, Clinical Geriatrics.1944David S. Fox, immediate past presidentof the Chicago Medical Society, chairman of Woodlawn Hospital's department of surgery and secretary of thehospital's Board of Directors, wasnamed president-elect of the IllinoisState Medical Society (ISMS). Dr. Foxis a former ISMS first vice-president andtrustee, and is a delegate to the American Medical Association.Dr. Fox also is chairman of the Committee on Moves to Counter Litigation ofthe ISMS Task Force on ProfessionalLiability, and a member of the ISMSCommittee on Constitution and ByLaws.Dr. Fox was recently appointed amember of the Illinois Department ofRegistration and Education' s MedicalExamining Committee.1945Eugene R. Mindell is professor andchairman of the department of orthopedics at the State University of NewYork, Buffalo, School of Medicine. Hewas recently elected a member of theAmerican Board of Orthopedic Surgeryand, beginning this fall, will serve for sixyears.1952Louis Gluck, a professor of pediatricsand reproductive medicine at the University of California, San Diego, will receive the Arvo Ylppo award this October at the International Congress ofPediatrics in New Delhi, India. Thisaward is presented every five years bythe five pediatric faculties of Finland, toan awardee who has made the most significant contributions during those fiveyears.Dr. Gluck was involved in pediatricmedicine, teaching, and research at Stanford University, Yale University and theUniversity of Miami before joining theUniversity of California, San Diego.1954Peter D. King has a full-time privatepractice of psychiatry in Encino,California and is a clinical professor atthe University of Southern CaliforniaSchool of Medicine. He is also directorand chairman of the Training Institute ofthe Los Angeles Group PsychotherapySociety and is engaged in research on theetiology of schizophrenia and early infantile autism. He writes that at the ageof 50 he is the proud father of a baby girl40 born on April 25. He has three olderchildren by his first marriage.1963Bernard J. Mizock recently opened anoffice in Chicago for the practice of general surgery. Dr. Mizock is on the staffof Illinois Masonic Hospital. He and hiswife Bonnie live in Skokie and have ason, 8, and a daughter,S.1964Daniel Paloyan has entered the privatepractice of gastrointestinal and generalsurgery and joined the department ofsurgery at Evanston and GlenbrookHospitals. Dr. Paloyan was assistantprofessor of surgery at the University ofChicago since 1971.1965Harris C. Taylor is chief of the divisionof endocrinology at the Lutheran Medical Center in Cleveland, Ohio. He is alsovisiting physician in the Endocrine Clinicat Cleveland Metropolitan GeneralHospital. Dr. Taylor is a diplomate ofthe American Board of InternalMedicine, Subsection of Endocrinologyand Metabolism, and a trustee of the Diabetes Association of Greater Cleveland.1966Julian J. RimpiJa is engaged in the private practice of medicine and was recently appointed consultant in gastroenterology at Christ Hospital in Oak Lawn,Illinois. Dr. Rimpila was nominated tothe Chicago Public Schools Hall ofFame by the principal and faculty ofJohn B. Murphy Elementary School,which he attended.1967Francis J. Lumia is a staff physician andclinical assistant professor of medicine atTemple University School of Medicine,Philadelphia.1968Fitzhugh Mullan has written an autobiographical account of his medical schoolinternship and residency entitled, WhiteCoat-Clenched Fist: The PoliticalEducation of an A me rican Physician,published by Macmillan. Dr. Mullanlives in Garrett Park, Maryland.1969Mark Faith recently joined the CarleClinic in Urbana, Illinois after completing a general surgery residency at theUniversity of Florida in Gainsville, andtwo years in the Army at Fort Knox. 1970David Grove has just begun a cardiologyfellowship at Duke University. Heserved his internship and residency atCase Western Reserve University inCleveland. He and his family have spentthe last three years in Germany.1972Sandra J. Ginsberg is an assistant professor in hematology and oncology at theSyracuse University Medical School inNew York.1973Andrew Marc Churg is an instructor inthe department of pathology at StanfordUniversity School of Medicine.G. Robert Cooley is engaged in the private practice of orthopedic surgery inSchenectady, New York.Jan P. De Roos is an associate in orthopedic surgery at the Sheboygan Clinicin Wisconsin.Richard W. Furlanetto was appointedassistant professor in pediatric endocrinology at the University of TexasMedical Branch in Galveston.Richard Gaeke is a fellow in the section of gastroenterology at the University of Chicago.Jeffrey Gordon is a research associatein medicine at the National Institutes ofHealth in Bethesda, Maryland.Vernon P. H. Horn is a cardiology research fellow at the University of TexasSouthwest Medical School in Dallas.Joel E. Kleinman is a clinical associatein psychiatry at St. Elizabeth's Hospitalin Washington, D.C.Daniel M. Knowles is a fellow in thedepartment of pathology at ColumbiaUniversity College of Physicians andSurgeons in New York City.Rudiger Kratz is a fellow in the department of neurology at WashingtonUniversity in St. Louis.Dwight R. Kulwin is serving his residency in ophthalmology at the University of Wisconsin, Madison.Lee Leserman is a clinical associate inpediatrics at the National Institutes ofHealth in Bethesda, Maryland.Richard R. Lichte is finishing his residency in emergency medicine at Cincinnati General Hospital.Hywel Madoc-Jones was appointed associate professor with tenure in the division of radiation oncology at WashingtonUniversity in St. Louis.Kenneth L. McClain is a research associate in pediatrics and virology at theNational Institutes of Health in Bethesda, Maryland.Gregory J. Milmoe is serving his residency in otolaryngology at the Yale-New Haven Hospital in New Haven,Connecticut.Lois Anne Nelson is a fellow in pediatric allergy and immunology at the University of Rochester, Strong MemorialHospital.David M. Ota is a fourth-year residentin general surgery at the University ofTexas in Houston.Theodore J. Pysher is a fellow inpediatric pathology at Children's Hospital in Los Angeles.James B. Reuler was appointed assistant professor in internal medicine at thePortland Veterans Administration Hospital in Oregon.James E. Schwanke is engaged in theprivate practice of pediatrics in SanFrancisco.Stanley S. Schwartz is an endocrinology fellow in the department of medicineat the University of Chicago.Jeffrey D. Semel is a fellow in the section of infectious diseases at the RushPresbyterian-St. Luke's Medical Centerin Chicago.Michael H. Silverman is a clinical fellow in the section of rheumatology at theUniversity of Colorado in Denver.Stephen P. Spielberg is serving his residency in the department of pediatricsand pharmacology at Johns Hopkins inBaltimore.Mark C. Steinhoff is an infectious diseases fellow in the department of pediatrics at the University of Rochester,Strong Memorial Hospital.Robert D. Toon is a fourth-year resident in orthopedic surgery at TorontoGeneral Hospital in Canada.William E. Trogg is a fourth-yearneonatology fellow in the department ofpediatrics at the University of Washington in Seattle.Barry E. Wright was appointed associate director of the retina service inthe department of ophthalmology at theMontefiore Hospital and Medical Centerin New York.James Kirk Wright is finishing his residency in plastic surgery at the University of California, Los Angeles.1976Douglas and Katherine EggJi recentlybought a house in Silver Springs, Maryland. Both are residents at Walter ReedArmy Medical Center.Former StaffWallace P. Berkowitz (General Surgery,intern-resident, '67-'69) has moved fromSt. Louis to Belleville, Illinois, where heis engaged in the private practice ofotorhinolaryngology. Marshall B. Block (Medicine, intern,'68--'69; endocrinology fellow, '70-'72) isengaged in the private practice of endocrinology in Phoenix, where he also iseditor of Arizona Medicine, the officialjournal of the Arizona Medical Association. Dr. Block is a fellow of the American College of Physicians.Leonard Brown (Psychiatry, resident,'67-'70) is assistant professor in the department of psychiatry at the Universityof Toronto. Dr. Brown was recentlyelected chairman of the Section onPsychotherapy of the Ontario Psychiatric Association.Angelo Creticos (Medicine, resident,'49-'50) was appointed medical directorand director of medical education ofHenrotin Hospital in Chicago. Dr. Creticos has been associated with HenrotinHospital since 1952, and currently is clinical associate professor of medicine atthe University of Illinois Medical Schooland consultant in medicine at the westside Veterans Administration Hospital.Raul E. Falicov (Cardiology, trainee,'66-'67; instructor, '68; assistant professor, '69-'74; and associate professor,'74-'76) was appointed director of cardiology and director of the CardiacCatheterization Laboratory at ChristHospital in Oak Lawn, Illinois.Jaime R. Gutierrez (Pathology, resident, '69-'71; instructor, '71-'73) has anew address: Calle 94, No. 15-63,Bogota, Columbia, South America.J. Laurance Hill (Surgery, AssistantAssociate Professor, '72-'77) has accepted a position as associate professorof surgery with dual appointments at theUniversity of Maryland and Johns Hopkins University.J. Leonard Lamb (Obstetrics andGynecology, intern-resident, '46-'49)has joined the staff of Mountain Comprehensive Health Corporation'sWhitesburg Medical Clinic in Whitesburg, Kentucky. He had been in privatepractice since 1956 in South Bend, Indiana.Geraldine Light (Anesthesiology, faculty, '46-'70) of Aurora, Illinois, was recently named to the City of ChicagoSenior Citizens Hall of Fame. She is onthe Advisory Committee for SeniorPlanning Services of the United Way andhas served on the board of directors ofthe Region Two Area Agency on Aging,which administers senior citizen programs in eight counties. In addition, sheis an active volunteer with the SalvationArmy's Second Horizon Center, whereshe holds a free monthly blood pressurescreening program, teaches severalclasses, and is a part-time outreachworker to other senior citizens in Aurora. John M. Merrill (Medicine, internresident, '72-'74) was appointed assistant professor in oncology at Northwestern University School of Medicine inChicago.Michael Newton (Obstetrics andGynecology, professor, '68-'77) accepted a position as professor of obstetrics and gynecology and director ofgynecologic oncology at NorthwesternUniversity Medical School.Daniel J. Pachman (Pediatrics, instructor, '34-'40), Chicago pediatrician,received the Archibald L. Hoyne Awardof the Chicago Pediatric Society at itsannual dinner meeting on May 18. Theaward, in recognition of outstanding contributions to the field of pediatrics, waspresented by his daughter, Dr. LaurenM. Pachman (,61), associate professor ofpediatrics at Northwestern Universityand head of the department of immunology at Children's Memorial Hospital in Chicago. Dr. Daniel Pachman isprofessor of pediatrics at Rush University, clinical professor of pediatrics at theUniversity of Illinois, and chairman ofthe Illinois Pediatric CoordinatingCouncil.Richard S. Stein (Medicine, internresident-fellow, '70-'74) was appointedassistant professor of medicine in thehematology section at Vanderbilt University in Nashville.William Vaughn (Medicine, internresident, '72-'75) was appointed instructor in the department of medicine atJohns Hopkins University in Baltimore.American College of Surgeons FellowsThe following alumni were inducted asFellows in the American College of Surgeons at the 1976 American College ofSurgeons meeting held in Chicago, October 14:Louis William Baldwin (,59), PalmSprings, California; Robert Alden Bray(,59), Livingston, Montana; Edwin E.Breitenbach ('67), Garden Grove,California; Stanley William Coulthard(,68), Ann Arbor, Michigan; Lloyd N.Henry (,64), Sunny Isle, St. Croix, Virgin Islands; John M. Hessl (,64), SanMateo, California; Norman J. James(,64), Spokane, Washington; NormanLeaf ('66), Beverly Hills, California;Robert Sidney Levine (,53), Pontiac,Michigan; Ernest Artin N ore had ('62),Kirkland, Washington; Edward A. Person (,63), San Diego, California; Frederick George Schoenfeld (,64), Aurora, Illinois; Jerrold Howard Seckler ('68), Arlington Heights, Illinois; and Betty LouTom ('66), Los Angeles, California.Present faculty and former interns,residents, and faculty also inductedwere: James I. Ausman, Minneapolis,41Minnesota: Michael P. Flynn, BeverlyHills, California: Adele M. Gottschalk,Harbor City, California: Eusebio C.Kho, Scottsburg, Indiana: John FrancisLee, St. Petersburg, Florida: Martin C.Robson, Chicago, Illinois: Mitchell BenSheinkop, Chicago, Illinois: Nathan K.Steinberg, Rockville Center, New York:Russell Stuart Weeks, San Diego,California: and Luis R. Yarzagary,Maywood, Illinois.Divisional Alumni NewsBernard E. Conley (Pharmacology, B.S.'51, Ph.D. '56) is the author of Socialand Economic Aspects of Drug Utilization Research, Drug Intelligence Publications, Hamilton Press, Washington,D.C., 1976. Dr. Conley is Chief of theDrug Utilization Studies Program of theNational Center for Health Services Research in Rockville, Maryland.Dr. Arthur S. Dover (Microbiology,S.B. '64, M.S. '65) has a M.D. degreefrom the University of Southern California and is in the private practice ofpediatrics in Freedom, California. In1973-75 he was assistant professor ofpediatrics at the Universidad del ValleSchool of Medicine, Cali, Columbia,where in 1966 he was a fellow inepidemiology under the auspices ofTulane University. In 1967 he was a fellow in tropical medicine at LouisianaState University, and located in SanJose, Costa Rica: in 1970 he was supervisor of a special epidemiology project,the Malaria Eradication Program, inMato Grosso, Brazil. He has been aconsultant to several medical programs,including the World Health OrganizationSmallpox Eradication Program inBangladesh in 1975.Miriam P. Finkel (Zoology, B.S. '38,Ph.D. '44), a senior biologist at ArgonneNational Laboratory, was presented a1977 University of Chicago Award forDistinguished Performance for her continuing contributions to science andtechnology at Argonne. For 30 years shehas been a major influence in the field ofradiation biology, for her applied work inradiotoxicity and her fundamentalstudies of tumor induction. Her work onthe toxicity of radionuclides provided thefundamental guidelines for theestablishment of permissible dose levelsby the International Commission onRadiation Protection, and she was thefirst to show the causal and dosimetricrelations between exposure to radionuelides and the induction of bone cancer.Dr. Ignacio Galindo Estrada (Mathematical Biology, M.S. '66) was electeddirector of the I nstituto de Geofisica of42 the Universidad Nacional de Mexico.He 1967 he received a M.D. degree fromthe University of Mexico and in 1972 aPh.D. from the University of Basle.Mahendra P. Jarnuar (Microbiology,Ph.D. '65) provided the following information: After leaving the Universityof Chicago he spent four years in theMedical Department of Brookhaven National Laboratory in New York as a research associate. His work there concerned problems of delayed hypersensitivity and ultrastructure of immunocompetent cells. He was subsequently called back to India as aReader in Zoology at Patna Universityto set up an electron microscope laboratory. In 1975 he went to Kuwait University on a two-year teaching assignmentwhere he taught immunology, cell biology and parasitology. This July he returned to Brookhaven National Laboratory.Robert P. Perry (Biophysics, Ph. D.'56), professor of biophysics at the University of Pennsylvania, has beenelected to the National Academy of Sciences.Class Chairmen Cited for1976 Fundraising EffortClass chairmen were honored at theMedical Alumni Day breakfast on June 8for their efforts in leading a most successful 1976 Medical Alumni FundDrive. Acting Dean Robert Uretz introduced and thanked the twenty chairmen who attended the breakfast:Andrew Aronson, '69Joseph Baron, '62Eli Borkon, '37 (Carbondale, ILlMary Carroll, '49 (Indiana)Henry De Leeuw, '47 (Michigan)Walter Eidbo, '56 (Iowa)William Froemming, '43E. H. Given, '59 (California)Richard Gaeke, '73Leon O. Jacobson, '39Sumner Kraft, '55Lucille and Eric Lester, '72Charles P. McCartney, '43Julian Rimpila, '66Benjamin Spargo, '52Francis Straus I I, '57Arnold Tanis, '51 (Florida)Stewart Taylor, '45 (Wisconsin)Vida Wentz, '35The 1976 fund raised a total of$293,113, compared with $408,576 in1975. Thirty-eight percent of the alumniparticipated in the fund, an increase of 4percent. Twelve classes achieved morethan 50 percent participation. The following alumni received specialrecognition for their achievements, andwere presented a framed color photograph of the Medical Center:Dr. Vida Wentz, whose 1935 class hadthe highest percentage of participation-65 percent.Dr. Charles Schlageter, whose 1944class contributed the largest amount tothe Medical Alumni Fund.Drs. Lucille and Eric Lester, 1972co-chairmen, whose class had thegreatest improvement-an increase from13 percent to 35 percent.Dean Uretz met with the class chairmen in the afternoon to review the 1977goals of the Medical Alumni Fund and tostress the importance of alumni gifts tothe medical school. Dr. Asher J. Finkel('48), immediate past president of the association, and Dr. Charles P.McCartney ('43), current president, reminded the chairmen of the special opportunities for alumni to make gifts to themedical school during its 50th Anniversary Year, and also invited them to arrange mini-reunions during theNovember 14-15 celebration.The 1977 Medical Alumni Fund includes a 50th Anniversary Donor category which honors donors who give $250to the medical school. In return, eachdonor will receive a copy of the 50th A nniersary History, written by Dr. Cornelius W_ Vermeulen (,37).Dr. and Mrs. Louis PlzakNew Loan Fund EstablishedDr. Louis Plzak, Sr. and his wife Janiceestablished the Plzak Family MedicalStudent Loan Fund last June, in memoryof their parents.Theirs is truly a University of Chicagofamily: Dr. Plzak received his M.D.from Rush in 1927, Mrs. Plzak receivedher M.S. in Pharmacology from the University in 1959. Their four children areall physicians who received their M.D.degrees from the University-Louis, Jr.in 1958, Janice Craig in 1960, LindaWoodbury in 1961, and George in 1964.CalendarWednesday, October 19Reception for alumni andspouses during the AmericanCollege of Surgeons Meeting inDallas. Fairmont Hotel, 5:30-7:00.Friday, January 20-Sunday, January 29Hawaiian Continuing MedicalEducation Program on "TravelMedicine," offered by the JohnA. Burns School of Medicine,University of Hawaii. Program isjointly sponsored by the University of Chicago, Indiana University, Northwestern University,and the University of Illinois.Write to the Medical AlumniOffice for information.Medicine on the MidwayThe University of ChicagoThe Medical Alumni AssociationThe Pritzker School of Medicine1025 East 57th StreetChicago, Illinois 60637•Address corrections requestedreturned postage guaranteed NON-PROFIT ORG.U.S. POSTAGEPAIDPERMIT NO. 9666CHICAGO, ILL.50th Anniversary CelebrationMonday, November 14II :00 Awarding of Honorary Degrees at Special Convocation-Rockefeller ChapelCharles B. Huggins, M.D., Speaker12:00 Alumni Luncheon-Quadrangle Club2:00 Convocation Symposium by Honorary Degree Recipients-Quantrell Auditorium6:30 Civic Dinner-Hyatt Regency ChicagoMusic by Franz Benteler and his Royal StringsSpeaker to be announcedTuesday, November 1510:30 Dedication of Surgery-Brain Research Pavilion12:30 Alumni Luncheon-Quadrangle Club4:00 The Dallas B. Phemister Lecture-P-117Marshall R. Urist, M.D., Speaker8: 15 Special performance by the Chicago Symphony OrchestraCarlo Maria Giulini, Guest ConductorOrchestra HallWednesday, November 1611:00 The Walter L. Palmer LectureCharles C. Code, M.D., SpeakerContinuing medical education seminars are being planned by the departments.All seminars, named lectures and the Convocation Symposium are acceptablefor hour-for-hour credit by the AMA-Category I and the AAFP.You are urged to make your hotel reservation early. A limited number of roomsare available at the Center for Continuing Education on campus, 1307 East 60thStreet, Chicago, 60637. Write or call the Center at (312) 753-4462 for reservations.