/.M d· · --- th M·d.. e icme on e I wa� Vol. 30 No.1�'Jo1Bulletin of the Medical Alumni Association The University of ChicagoDivision of the Biological Sciences and The Pritzker School of MedicineA Warm Welcome.Dr. Daniel Charles Tosteson has been appointed Dean of the Division of the BiologicalSciences and The Pritzker School of Medicine at The University of Chicago. He has alsobeen appointed the Lowell T. Coggeshall Professor of Medical Sciences in the Department of Pharmacological and Physiological Sciences. Both appointments are effectiveJuly 1.Dr. Tosteson was Chairman of the Department of Physiology and Pharmacology atthe Duke University School of Medicine, Durham, North Carolina, before he came toThe University of Chicago. He is a past Chairman of the Association of American Medical Colleges, Washington, D.C.His new appointment at The University of Chicago was made by John T. Wilson, Provost and Acting President of the University, upon the recommendation ofa faculty committee. He succeeds Dr. Leon O. Jacobson, who has retired as Dean after nine years, tocontinue his research and teaching.In making the announcement, Mr. Wilson said:"We are delighted and honored that Dr. Tosteson has accepted the Deanship of theDivision of the Biological Sciences and The Pritzker School of Medicine and will becomethe first Lowell T. Coggeshall Professor of Medical Sciences. He is a scholar-physicianof the first rank."Dr. Tosteson brings to The University of Chicago a strong commitment to excellence in biomedical research and clinical medicine and a national reputation in the scien-tific community. I know he will provide the Division and assistant resident in medicine at Presbyterian Hospital,the Pritzker School with the leadership essential to en- New York City. Between 1951 and 1957 he was succes-hance the work on which their reputation in research and sively a research fellow at the Brookhaven Nationalpatient treatment is based. Laboratory, at the Laboratory of Kidney and Electrolyte"During Dr. Jacobson's nine years as Dean, the Metabolism of the National Heart Institute, at theDivision's research and its faculty have grown; in a Zoo physical Laboratory of the University ofnumber of areas of research it is a world leader. Its very Copenhagen, and at the Physiological Laboratory instrengths can be the sources of important opportunities in Cambridge, England. He was Associate Professor ofthe future. Dr. Jacobson has been a great builder in the Physiology at the Washington University School ofmedical area-in all the best senses; he has given the Medicine, St. Louis, in 1958-61, and became ChairmanUniversity a good heritage." of the Department of Physiology and Pharmacology atDr. Tosteson served as the elected Chairman of the Duke in 1961.Association of American Medical Colleges in 1973-74 Among his affiliations are the American Physiologicaland recently as Chairman of its Task Force on Health Society, the Society of General Physiologists and theManpower which formulated the Association's policy on Biophysical Society. He has served on the councils of allmedical manpower legislation. three of these societies and as President of both theHe has also been on the Scientific Advisory Board of American Physiological Society and the Society of Gen-the National Kidney Disease Foundation and has served eral Physiologists. He is a member of the Institute ofas a consultant to the Committee on Blood of the Na- Medicine of the National Academy of Sciences.tional Research Council and to the National Institutes of The Coggeshall Professorship to which Dr. TostesonHealth. has been appointed was established by the Trustees inHe is known for his research in the chemistry of honor of Dr. Lowell T. Coggeshall, Life Trustee andnatural and artificial membranes. His work has focused Vice-President Emeritus of The University of Chicagoon cellular transport processes, using red blood cell and Dean from 1947 to 1960 of The Division of themembranes as a model. Its object has been to learn how Biological Sciences and the School of Medicine.cells obtain their nutrition. Wilson said: "While serving as Dean, Dr. CoggeshallHe has been at Duke since 1961 and has been the guided the continuing growth of the University'S re-James B. Duke Distinguished Professor there since 1971. search and teaching program in the medical and biologi-He is expected to be particularly effective at The Uni- cal sciences and the expansion of its hospital and clinicalversity of Chicago because of its traditional emphasis on services. An internationally recognized authority onboth teaching and research. malaria and other tropical diseases, Dr. Coggeshall hasDr. Tosteson was born in Milwaukee, Wisconsin, in pursued a dual career as scientific investigator and ad-1925, attended Harvard University from 1942 to 1944, ministrator. His interests have extended to a wide rangeand received his medical degree there in 1949. He was a of public, private and professional activities, and he hasNational Life Insurance Fellow in physiology at Harvard received numerous awards for his contributions to medi-in 1947-48, and following graduation served as intern and cal science and education."Cover: Dr. Leon Jacobson (right! passes the mantle to Dr. Charles Tosteson. Dr. Jacobson has stepped downas Dean of The Pritzker School of Medicine. Dr. Tosteson's appointment to that position was effective July 7.Medicine on the MidwayVolume 30, No.1 Spring 1975Bulletin of the Medical Alumni Association ofThe University of Chicago Division of the BiologicalSciences and The Pritzker School of Medicine.Copyright 1975 by the Medical Alumni AssociationThe University of ChicagoEditor: Nancy SelkContributing Editor: James S. SweetPhotographers: Mike Shields, Sarah Lavicka, Jac Stafford, Mel OsterChairman Editorial Committee: Robert W. Wissler ('48)Medical Alumni AssociationPresident: Henry P. Russe (' 57)President-Elect: Asher J. Finkel ('48)Vice President: Myron M. HipskindSecretary: Francis H. Straus II ('57)Director: Katherine T. WolcottCouncil MembersHoward L. Bresler (' 57)Sumner C. Kraft ('55)Lauren M. Pachman (,61)Donald A. Rowley (' 50)Randolph W. Seed ('60)Joseph H. Skom (,52)Otto Trippel ('46) ContentsOrganizing for Patient EducationBarbara GilothThe Thought of No ThoughtMedicine and Philosophy in Japan and East AsiaJeffrey C. LaurenceSenior Scientific SessionResidency Assignments-1975Comprehensive Medicine in Industry_Bi-Sci Council ExpandsFundraising: A Family AffairMedical Alumni Day-1975Humanizing Medicine: Patient RelationsNews BriefsIn MemoriamDepartmental NewsAlumni News 48142425282931394344503Organizing for Patient EducationBarbara Giloth"This is my first baby and I'm worried about crib death.What can I do to prevent it?" ... ''I'm afraid that if Ihave a hysterectomy I won't enjoy sex anymore since mywomb will be gone. Is this true?" ... "Why do I have tobring in 24-hour urine specimens?" ... "What does itmean if I sign this consent form for surgery?" ... "Howcan I follow this special diet when I haven't got muchmoney?"These are only a few of the countless questions thatChicago Lying-in patients ask during the course of a typical day. There are probably many other questions thatare not asked because of fear, because of an inability toarticulate the problem, or because of lack of time.In the past, physicians and nurses have considered patient education to be an integral part of their interactionwith patients. Questions like the examples above wouldhave been answered by these professionals in the normalcourse of treating the patient. In recent years, however,anomalies of modem health care have kept this mostbasic aspect of patient education-that of providinginformation-from being accomplished. In part, this isbecause there are now many professionals involved ineach patient's care, and presentation of information becomes difficult to coordinate. Additionally, the medicalchart, which is the normal communication device linkingthese professionals, is generally void of educational assessment and planning information. Thus, informationpresented to the patient is often inconsistent, duplicativeor incomplete.Another problem in the provision of adequate patienteducation has been the changing health needs of thepopulation. Patients with acute illness have need ofprompt medical treatment and a brief explanation of theirillness and how to prevent a recurrence. However, thepercentage of acute illnesses is decreasing and chronicdisease is becoming the most significant medical problem. Therefore, patient education must now providelong-term support to motivate the chronically ill to followincreasingly intricate treatment programs. Research nowshows that educated patients are more likely to followprescribed medication and activity regimes, are morelikely to keep appointments and are less likely to sufferfrom complications than patients who have not participated in an educational program. A New Jersey study,for example, recently showed that a group educationprogram for patients with congestive heart failure notonly increased their knowledge scores but significantlyreduced their number of readmissions as well as lengthsof stay as compared to the previous experience of thesesame patients and that of a control group. Other studies,particularly those pertaining to chronic disease therapy,have shown similar results.Paralleling the present need for chronic disease patienteducation is the growing realization that prevention of4 Dietitian Anne Daly counsels a diabetic patient in the high risk obstetricsclinic.disease requires many behavioral changes by persons before they become ill. Lifestyle changes in diet, smokingand exercise are now recognized as being essential elements of health maintenance for the person who is overweight, sedentary and a smoker. Extensive long termeducation is necessary to inform, motivate, and supportsuch changes. How can all this education be provided?Patient Education CoordinatorIn June of 1974, the position of patient education coordinator was established within the Chicago Lying-in administration. Its primary purpose is to coordinate the development of comprehensive in-patient and out-patienteducational programs. In this context, patient educationKaran Williams. out-patient nurse. assesses the educational needs of a thirdtrimester patient.Instructor Jane Baskins (right) works with an expectant mother in the physical fitness program.here refers to any set of educational experiences plannedfor the patient as a component of health care. It may takethe form of a class, a group session, a one-to-one encounter, a movie, or a pamphlet; it may be implementedby a physician, a nurse, a social worker, a healtheducator, a clinic coordinator or some combination ofthese. Its essential element is that it is planned intervention that takes into consideration the patient's needs andhas a primary objective the active involvement of thepatient in the health care process. It is important to notehere that patients learn from their health care experiences whether or not an educational program is plannedfor them. Unfortunately, in many instances, a patientinadvertently "learns" things that will be detrimentalrather than helpful to the treatment process. If, for example, a person's questions are dismissed as unimportantby a clinic coordinator, nurse, or physician, the patientwill learn not to ask questions in the future.In order to develop comprehensive programs, givenNurse Edith Baker teaches a new mother how to bathe a baby. these definitions and constraints, the coordinator mustbring together the people and resources that are neededto plan and implement patient education programs. Thecoordinator cannot be primarily responsible for the implementation of the education but can direct a multidisciplinary team to work through the educational planningprocess from assessment, to problem definition, to program plan, to program evaluation. While important content decisions must be left to the various specialists whowill be actively involved in planning, the coordinator alsofunctions as an educational consultant by helping teammembers to organize program components and materialsin ways that can most effectively be understood andutilized by patients.In order to clarify the role played by the coordinatorand to provide information about the recent progress ofprogram development here, a specific example of the developmental process of a current project is presentedbelow.Head nurse Edith Matulac, OB-CYN faculty member Dr. Joseph Swartwoutand patient education coordinator Barbara Ciloth discuss family planningprogram.Family Centered Maternity Education Program"Preparation for Parenthood" has always been a part ofthe Chicago Lying-in maternity care. The new overallmaternity education program seeks to broaden the original program and make it more meaningful to a wide variety of patients. Maternity education in the past hasprimarily consisted of classes geared to the woman whois married and having her first or second child. The neweducation program also seeks to assess and meet theeducational needs of the teenage parent, the drug addicted mother, the single parent and the woman withmany children. If all these types of patients are to bereached, different approaches and a variety of optionsmust be available. For example, while an organizedseries of classes appeals to certain expectant parents,others, because of overwhelming responsibilities athome, need informal group discussions at the time theycome for their clinic appointments.5To plan such a program, the patient education coordinator has been working closely, since September 1974,with the CLI Director of Nursing, the obstetric nursingsupervisors and clinic specialists. From this effort hascome a plan for a program in maternity education intended to provide information and resources needed bythe prospective parents to cope physically, emotionallyand psychologically with each phase of the maternitycycle. The program includes objectives, expected patientoutcomes, content modules and a patient flow diagram.While the planning group has always recognized that theexpectant parents will retain the right to decide the extentof their involvement in the education program, it has accepted the responsibility for establishing and maintaininga climate conducive to learning experiences. .Responsibility for the implementation of the nursingcomponent of this plan has been turned over to a newlycreated subcommittee on maternity education, which willeventually function as part of an overall patient educationplanning effort. Members of this committee includenurses from the out-patient department, the birthrooms,the nursery and the post partum floor, who have acceptedresponsibility for patient education on their units. Thepatient education coordinator will serve on this committee primarily as an educational consultant. One of hermost important responsibilities will be to incorporate intothe committee's implementation plans the medical, socialservice, dietary, and administrative inputs and constraints. Major tasks before the group include establishing the logistics of educational assessment and programming, developing communication and coordinationmechanisms among units, and providing for the continuous monitoring and evaluation of the programs.The paucity of good evaluations of patient educationprograms in the past has considerably slowed the implementation of patient education as a necessary ratherthan optional part of patient care. The typical evaluationof a patient education program has answered such questions as, "Did the participants enjoy the class?" "Didthey think that useful information was presented?" Thisinformation is necessary but the approach does not attempt to answer the most important question-"Did theprogram have the desired effect?" More sophisticatedprograms, which evaluate instructional objectives inorder to tabulate the amount of knowledge gained byparticipants, do exist. However, too often, this type ofevaluation (coupled with an assumption about the humanbeing's supposed "rationality") leads to the erroneousconclusion that knowledge and action are perfectly correlated.Evaluation of the maternity education program will attempt to measure program effect. Measures of ultimateeffect would include the reduction of maternal and infantmorbidity and mortality rates that could be attributed tothe patient education program. However, these are affected by so many other variables that, in the short run atleast, they would not be sensitive to the effects of thisprogram. An assumption can be made here that the lowering of maternal and infant mortality and morbidity willoccur as a result of patient education programs. Insteadof measuring these rates directly, this evaluation will6 focus on collecting expected patient outcome data, theshort run measures of program effect.The maternity cycle has been divided into three timeperiods: (1) prenatal (or antepartal); (2) labor and delivery (or intrapartal); and (3) postpartal. For each of theseperiods, the educational planning group has enumeratedthe desired patient actions or outcomes that could beproduced by an education program and that could, inturn, have important ramifications for the health ofmother and baby. Questions such as "Can the patientdescribe a normal prenatal diet?" will receive consideration but the more important question-"Did the expectant mother follow the prenatal diet plan?" -will be emphasized. If it is determined that the patient knows whatto eat but is not following the diet, then it will be necessary to reexamine the educational program. It may bethat the woman really doesn't like the specific foods thatwere suggested to her (this often occurs with the milkrequirement, for example); it may be that the womanfeels she doesn't have enough money to buy the recommended food items; or, it may be that she really doesn'tbelieve that changes in her diet will have an importanteffect on her baby. Whatever the cause, it must beidentified so that the professionals can then help themother move from knowledge to action more successfully.Expected antepartal outcomes include: "Follows prenatal diet plan," "keeps prenatal appointments,""chooses among patient education classes," and "seeksmedical care when a danger signal occurs." Examples ofintrapartal outcomes to be tabulated include: "Comes toCLl admitting in true labor," and "utilizes appropriatebreathing and relaxation techniques throughout thestages of labor." Postpartal outcomes during hospitalization include: "Follows proper procedures for postpartumbreast care," "feeds baby properly and comfortably bybottle or by breastfeeding," and" selects pediatric healthcare referral." "Keeps six week check-up appointment"and "accepts chosen family planning method at the timeof this check-up" are the two final postpartal outcomes tobe measured. The planning group expects, of course, thatthe effects of the program will be longer than the six weekcheck-up, although measurement beyond this point isdifficult.A Walk into the FutureWhat might this program look like to a maternity patientif all of its parts were implemented immediately? As soonas the expectant parent has registered, * she would moveto the obstetric clinic for a prenatal orientation class andfirst clinic appointment. Her nursing assessment wouldbe the foundation for the process of educational planningand would supplement the physician's evaluation of thepatient. At this or the next appointment, the patientwould be asked to choose among the educational optionswhich would include the basic prenatal series, group discussions during her clinic appointment, and/or one-to-* This example assumes that the woman has registered early in thesecond trimester; compressed educational programs will be designedfor those who do not register until the third trimester.one counseling by a nurse. Referrals might be made atthis time to, for example, the dietician for specialized dieteducation or to social service for counseling. Additionaleducational options, such as the prenatal exercise program, would be suggested and the patient's choices referred to her physician for approval.At a clinic appointment early in the third trimester, thenurse would again be involved in a formal assessmentprocess in order to help the expectant woman and, inmany cases, the expectant father, evaluate their needsand make additional choices. At this time, a decisionwould be made as to whether or not another personwould be with the woman in the labor and/or deliveryroom. This decision would, of course, be discussed withthe patient's physician and the resulting choice noted inthe chart. Physician input would also be utilized to helparrange not only for preparation of the expectant motherbut also for whomever she has chosen to be with herduring the intrapartal period. Class choices at this timewould include a "preparation for labor" series, a "preparation for hospitalization" class, a "preparation forbaby care" class, a hospital tour, group discussion duringclinic, and/or referral to outside programs such asLamaze classes.As the woman begins labor, nursing and medicalevaluations would encourage the parents to reassess, ifnecessary, previous decisions about the labor and delivery period and articulate the kind of support they willneed during the intrapartal stage. After delivery and thetransfer of the new mother to the postpartum floor, anadditional nursing assessment would be made and postpartum orientation begun. By the second day postpartum, the mother would be invited to attend classes onbaby care, mother care and/or family planning and wouldbe given written information by physicians and nurses tosupplement oral instruction. The third day after delivery,the patient and nurse would complete the discharge plan,discuss home care information and make six-week andpediatric appointments as recommended by the medicalstaff.At the six-week check-up, the new mother would beinterviewed and referred to parent groups, social service,and/or community referrals as needed. She would be encouraged to join a postpartum exercise class in order tostrengthen her muscles and return her body to its prepregnancy shape and weight. This visit would also focuson evaluation of some of the postpartum patient outco-mes and would be a time when the patient couldevaluate her maternity experience.What's Available Now?Even though the maternity education program has notbeen completely implemented, increasing numbers ofeducation options are offered for expectant parents at theChicago Lying-in Hospital. There are two basic prenatalseries of five classes each; one meets Tuesday afternoons, the other Wednesday evenings. Each series includes both lecture and discussion and covers fetal development, physical and emotional changes during pregnancy, nutrition, labor and delivery, and parenting.Concomitantly, an expectant mother in the first two trimesters of pregnancy will be encouraged to take a prenatal exercise series designed to strengthen muscleswhich will be needed during labor and delivery. A secondtype of exercise class, a preparation for labor series, isoffered to third trimester patients; it focuses on breathingand relaxation techniques for use during the three stagesof labor. A third type of exercise class is available forpostpartum women after their six week check-ups. Itconcentrates on the return of body shape and tone topre-pregnant states. Registration for these classes mustbe accompanied by a completed physician permissionform.Another educational option is a young mother's obstetric program, which is designed to meet the needs ofthe teenage parent-to-be. Group sessions are scheduledat the end of the special Wednesday morning clinic todiscuss the particular concerns of the pregnant teenageras well as the normal concerns of any pregnant woman.A multidisciplinary group, including a nutritionist, nurse,health educator, and social worker, participates in thesesessions and offers individual education and support.Another informal group session and film showing forprenatal patients is now being organized for Mondaymornmgs.A dietician is available part-time in the out-patient department to provide specialized nutrition education forhigh risk expectant mothers while newly developed education materials on nutrition aid the nurse with normalprenatal nutrition education. On the postpartum floor,nurses are giving individualized instruction in feeding,bathing and general baby care and are in the process oforganizing group discussion sessions for postpartummothers. A new program staffed by volunteers is justbeginning. It will provide basic information on familyplanning to interested postpartum women before discharge.The important differences between what is availablenow and what will be available in the future, however,are the following: (1) the future program will meet theeducational needs of an increasing percentage of CLIexpectant parents; (2) more emphasis will be placed onthe assessment of patients' educational needs andabilities; (3) more emphasis will be placed on developingcommunication mechanisms among the professionals involved in a patient's care; and (4) future program evaluation will attempt to measure expected patient outcomesin order to document educational effect.Comprehensive Patient EducationWithin the next year, a Patient Education Committee willbe organized by the coordinator. It will be responsible forthe overall planning of patient education programs atCLI. This committee will be composed of the maternityand gynecologic nursing subcommittees on patient education, representatives from the dietary department, social service, and administration, and faculty medical advisors. This committee, by its multidisciplinary nature,will allow for increased communication among professionals and thus a greater focus on the patient as a totalperson.7The process used over the past year to plan and develop a program of maternity education will be applied toother areas of educational need. For example, patientorientation to the hospital remains an important issue,especially for the surgical patient. Health education ingynecology, particularly in the areas of cancer prevention, family planning, venereal disease, and human sexuality, needs development. More comprehensive nutritional education is essential for a population of patientswho are often overweight as well as undernourished. Increased numbers of patients with chronic disease from the high risk obstetrics service and the oncology (cancer)service need increasing amounts of sophisticated and individualized patient education. The groundwork hasbeen laid for meeting many of these educational needs.Much work, of course, remains to be done to insure thateach CLI patient receives the information, education andsupport required to return to and maintain health or tomanage successfully a chronic disease.Barbara Giloth is Patient Education Coordinator, ChicagoLying-in Hospital.The Thought of No Thought:Medicine and Philosophy in Japan and East AsiaJeffrey C. LaurenceIt was during the third century B.C. in China, at the completion of the Great Wall, that adept Hu-ch'iu felt movedto caution the philosopher Lieh Tzu on his journeysthrough East Asia.The greatest traveller does not know where he is going; thegreatest sight-seer does not know what he is looking at. Histravels do not take him to one part of creation more thananother; his sight-seeing is not directed to one sight ratherthan another. ... he whose sight-seeing is inward, can inhimself find all he needs .... it is a poor sort ofjoumey that isdependent upon outside things.I do not presume that my recent peregrinationsthrough Hong Kong, Japan, and the Philippines have approached this enlightened road offered by Hu-ch'iu. But,among clinic rounds and research in Osaka, temples andgardens in Kyoto, and a panacea made of dragori bones inMacao, I have sought to learn from all that is here pragmatic and modern, and yet have aspired to capture, andto treasure, its ancient rituals, wisdom, and beauty. The8 Japanese are said to be endeared to sakura, the cherrytree, because of its glorious appearance hearkening anephemeral life. In that manner, perhaps I've succeededin understanding something of the way and philosophy ofthe people I've encountered, those who have taught andtouched me, and those I have aspired to help. In Zen, lifemay be seen as the "thought of no thought." And life,mixed with medicine and flower-viewing, has for this pastyear been a grace."They [the Japanese] would never_�ay, 'We have conquered it,' but they would thank Nature for revealing hersecrets in response to our prayers rendered in the form of'experiments.' " Thus did a Buddhist priest attempt todefine a basis for the dawn of Western science in Japan,and to establish the history and mores of the people I wasto join at Osaka University Medical School. At least thiswas the preconception I had come with. I was soon todiscover that most of medical research and practice ofthe Japanese is devoid of a traditional form, as the paceand the gadgetry, the extent of their vision and the direc-Jeffrey Laurence, the Institute for Cancer Research, Osaka.tion of their pursuits, parallels, and at points exceeds, thestyle and fecundity of the West. This is due in part totheir eagerness, throughout many dynasties, to acceptOccidental leads, and to a fire for learning. It is as onevisits the myriad institutions of this country and regionthat one obtains a glimpse of the delightful exceptions ofacupuncture and Oriental herbs.In the summer of 1634, lemitsu, the third Shogun ofJapan, created a settlement in Nagasaki called Dejima, towhich all foreigners were banished. This initiated aperiod of isolationism that was to persist, in varying degrees, for the next two hundred years. It was during thisera that a few scholars, notably those interested inmedicine, strove to open the "closed doors," eventuallyeliciting the personal support of the shogunate, regardless of its public decrees. Presently, At Ekoin, a templeon Kyushu island, there stands a monument erectedwhere the first dissection by foreign anatomists was recorded. Amazed at the accuracy ofthe illustrations in thetomes these physicians had followed, a group of doctorsdeciphered one of their volumes. A plaque notes in kanji,"This was the first of the scholarly translations evermade of a scientific book from the West. ... Thus thespring of Dutch Learning first welled up here and continued to supply an infinite life to the stream of modemculture in Japan." In concord with this predominantlyGerman and Dutch influence upon science, medical education consists of a six-year program following graduation from a secondary school. The competition for placesin the "Imperial Universities" vastly overshadows anycomparable rivalry in the West. The number of acceptedapplications is now, at best, but 5 percent. While theactual incidence of such tragedies is low, each year thenewspapers glaringly detail the seppuku-ritualsuicides-committed by unsuccessful candidates. It isthis, and the fact that parents often arrange for specialtutors to prepare their children at the age of six or sevenfor entrance into these public schools, that has challenged the education ministries to search for a change. It appears, however, that significant revisions will not sooncome.After two years of a general education, including surveys of the basic sciences and studies leading toproficiency in both English and German, one embarksupon a medical program organized in a manner similar toour own. Yet, all clinical experience is much more byobservation than participation, as the student is usuallynot permitted a direct involvement in an individual's careand management. Night calls and the drudgery and thepleasure of"scut work" are here unknown. It is a systemby which, throughout these six years, one cannot administer drugs, routinely start intravenous lines or perform minor surgeries. One may not advance precociouslywithin a set course that leaves most practical traininguntil after graduation and that has some administratorsseeking to establish alternative regimens. Indeed, a newmedical school in Hamamatsu is to admit its first classthis fall. Having ubiquitously repeated my very prejudiced views on styles of medical learning, I was invitedto discuss the preparation of its syllabus. It is now planning to provide the first curriculum based upon an organsystem analysis, and will encourage senior faculty members to serve as preceptors and mentors for discussionswithin small student groups. But at Osaka UniversityHospital I played a very special part.There are two long corridors crossing at an operations'desk and mobile racks with charts that mix kanji withEnglish-to befuddle the uninitiated. Eight interns andresidents join four rather tired looking medical studentsdesperately seaching for something intelligent to say, tofollow the Chief of Medicine, Dr. Yamamura. A nursehands him a hot towel for his face and hands before hisentrance into a patient's room, then rushes to prepareanother for his exit. A spouse or relative, often sleepingon a cot in the same room or in a nearby corridor, offersus all a deep bow, from the waist, as the patient iscautioned from rising to do the same. The warning isfutile. There is a formality of presence and of respect inthe Orient. The physician commands the attention andfacade of omnipotence, and, as everywhere, must continue to earn it. The discussant is standing at the bedsideupon our arrival, having already arranged the pertinentrecords, electrocardiograms, and lab summaries. I amusually handed the x-rays.I follow along with this mass of medicine during wardrounds of the oncology/allergy and endocrine/metabolismservices, which also encompass emergency general medical patients. I try for all the world to act the "grandAmerican consultant." I imagine it is reasonable to suppose that there is not a specific "Western opinion" on theetiology of every sign and syndrome, not always a typically Occidental raison d' etre for the procedures andtreatments selected for divergent cases. But this logicfrequently went unheeded as I attempted to establish thatI did indeed represent a significant part of the Westernscene. Thus, with an outwardly equiponderant ease, Istruggled to formulate the differential diagnosis ofichthyosiform erythroderma, and to provide an estimateof the number of jiggers of Johnny Walker Black Label9required to induce Laennec's cirrhosis, based on threeflasks of sake. It didn't always work..There was unceasingly a fascinating array of cases referred to our clinics, including advanced cases and clinical variants of certain infectious diseases I had not witnessed in America. But my main concern was with theoncology patients, and an evaluation of the therapeuticpotential of a cell wall skeleton extract of the Mycobacterium BCG. This brought me into contact with manyindividuals suffering a divergency of malignancy, instages we all hoped were "cures," as well as in advancedprogression. It startled me, at first, to see how brightlyeffervescent and expectant individuals with obviousmassive tumor metastases appeared, something which Iinitially attributed to a thought innate in the philosophy ofEast Asia or an exquisite faith in medicine. It was noneof these. I constantly employed the euphemism "disease" or "tumor" while on rounds, avoiding theJapanese term gann, and the word cancer itself, as wasprotocol on the wards. It was only after one doctor, looking up from a Time article, asked me exactly how Mrs.Ford discovered that she did indeed have breast cancer,..............,....�-Toii-dere, the tallest pagoda in Japan, in Kyoto.10 that I realized these patients were not given a diagnosis,nor a hint at prognosis. Their families are fully informed.But at Osaka, as in many other university hospitals, thepatients themselves, almost without exception, are"spared" the knowledge. Perhaps they do eventuallydiscern what is happening, but this must be by accident.Thereafter, I approached each individual with a bit morediffidence, wishing my conversational abilities inJapanese weren't still embryonic.I acquired a wealth of information during my tutelageunder Dr. Yamamura and, being constantly queried onthe basics and minutiae of a multitude of miseries, wasstimulated to follow the latest medical journals, as well asto bear in mind that people were the ultimate motivebehind the mice I was infecting and curing in the rooms afew buildings away.Over Japan there are stars.Stars that speak with foreign accentsStars cleaned with cotton wool and tweezersAnd sterilized with formalinStars charged with radioacti vity.On wintry nights-Every night-They stretch like a heavy chain.There is an old term in Japanese, imamekashi, whichroughly signifies one's embrace of only the very newestthings. For some, such as the poet Takenaka Iku in anexcerpt from his "Stars," there is something degradingabout it-the fashions, and flowers, and faces that alterwith Western design and whim. But to the extent that amedical technology nutured in the West has been adaptedand refined in Japan, it is a wonder. I visited the AichiCancer Institute in Nagoya, a sprawling complex devoted to the care and study of cancer and renal transplantpatients. I felt very much at home here, for annually anexchange of gastroenterology fellows takes place between The University of Chicago and Nagoya. I was extremely impressed by the facility with which gastroscopies and colonoscopies were performed, as well as bythe large number of such procedures routinely used. Indeed, perhaps because of the scalding servings of foodconsumed in certain regions, the great quantities of particular condiments and preservatives employed, or somegenetic diathesis, gastric carcinoma is the leading causeof death from malignancy among both sexes in Japan.Upon my arrival, five sets of upper GI series, x-ray examinations of parts of the digestive tract, were waiting ona viewing screen. With no little trepidation I proceeded(in reality, was forced) to form a diagnosis from each.The direct visualizations were to substantiate, more-orless, my suppositions. Until a "fledgling doc" is placedin a situation such as this, one may never deeply appreciate a good junior clerkship in medical school!Always smiling serenely.Eating his four cups of rough rice a dayWith bean paste and a few vegetables,UnderstandingAnd never forgetting.If there is a sick child in the eastHe goes and tends himIf there is a man dying in the southHe goes and soothes his fearsNeither praisedNor taken to heart.That manIs what I wish to be.("November Third," Miyazawa Kenji)I have long been fascinated by the traditional physician, approaching the "barefoot doctors" of the greatexpanse of southwestern China, and by the foundationsof medical folklore. Fairly early during my stay in Japan Inoted one example. For, just before midnight December31, I joined most of Kyoto at Yasaka Shrine for theOkera Mairi, to capture the New Year's first fire on alength of tarred string from braziers fed by white-robedBuddhist monks. Okera, an ancient medicinal herb forthe stomach, is here burned until dawn. Legend offersthat if one eats breakfast cooked of these flames, one willbe free from disease throughout the year. Unfortunately,I extinguished my string before reaching home, and willthus not be able to personally attest to its validity. InJapan, the seers and soothsayers, mystically promotedhealers, and autonomous medical assistants have all butdisappeared, but many continue to follow Oriental prescription. Concoctions of legume and bile, snakeskin andlicorice, beetles and dragon (tiger) bones, are guaranteedto alleviate everything from colds to cancer. In China, itis a search for Fu Shih Yao, or the "never die drug."In the Japanese Alps, along the northeast axis of thiscountry, lies Toyama, a small city which was once themost active center of the Oriental drug peddler. It nowencompasses the Research Institute of W akan-Yaku,Chinese crude drugs. Here the pharmacologic, biochemical, and immunologic properties of extracts of materialspurchased in markets in Shanghai, Nepal, and Seoul areprepared and investigated. There is a special interest insubstantiating synergisms among divergent herbs, and inexamining the principle of the biphasic effect characteristic of traditional Chinese remedies, whereby the samepotion of crude drugs, apportioned according to the constitutions and conditions of individuals suffering fromvarious diseases, have markedly different, yet putativelyappropriate, effects. Panax ginseng has been widely usedin China since the Han Dynasty, during its centralizationand first encounters with the "barbarian" West of theRoman Empire. Saponin residues of this plant have recently' been reported by investigators from Toyama University to have striking mitotic, anti-diabetic, oranti-inflammatory properties, depending on the fractionextracted, thereby supporting a concept-calledlegend-that is at least two thousand years old.There is a large medical garden on the outskirts ofToyama where many species of herb, described inChinese drug manuals, are cultivated. I borrowed a fewsamples. And at the conclusion of my tour the director,Dr. Oura, handed me a vial filled with some small blackpills. I was told to suck on one and, not having beenoffered an alternative, found my tongue quickly anesthetized by a bitter tasting, errhine paste. I was subse- quently informed that it was a mixture of bear gallstones,musk, and cinnamon, a Chinese prophylactic for colds.I've not coughed nor sniffled yet.I may be silent, butI'm thinking.I may not talk, butDon't mistake me for a wall.(" Silent, but ... ," Tsuboi Shigeji)I was soon to realize that one's work here is constantlyconsidered an integral part of one's personal life. Orrather, that one's work is one's personal life. I remaineduntil 9 p.m. in the laboratory my first night, heralding avery familiar pattern. I was informed at the outset that Ishould see myself as a stimulus to the rest ofthe group sothat its members will become even more productive!At the Institute of Cancer Research, where I am presently a research associate in the section of immunology,basic investigations into the mechanisms of viral andchemical carcinogenesis, genetic control of the immuneresponse, tolerogenesis, and enhancement and suppression of neoplastic growth are being conducted. There aretwo professors, two instructors, and six postdoctoral fellows within our division . .I am the youngest and the leastprofessionally titled of the group. Their spontaneity,knowledge, and capacity are superb and far-reaching.Any shyness or introversion some have attributed to a"typical character" of the Orient is nowhere here evident. The laboratories are well equipped but dismallyfurnished and suffering from a dearth of ancillary staff;one is forced to wash special glassware, sterilize his owninstruments, and even insure that his mice are alwayswell nourished. In the absence of tax incentives for private donations to universities, the preparation of grantproposals to the Ministry of Science is almost a monthlyaffair.The attempt here to establish rapid international communications among medical institutions has led to a welcome pleroma of conferences sponsored by many nations. As a guest of the "Fifth International Symposiumof the Princess Takamatsu Cancer Research Fund" inTokyo, I joined the literati, helping to edit and write partof a book entitled, Host Defense Against Cancer and ItsPotentiation (University of Tokyo Press, 1975). Duringthis meeting, several papers were presented, from ourInstitute and others in Japan and the U.S., on the carcinostatic activity of Lentinan, a polysaccharide residueformed by hot water extraction of the edible mushroomLentinus edodes. For many centuries there was a strongbelief amongst the peoples of East Asia that various fungiof the family Basidiomycetes had the ability to inhibit thegrowth of tumors. As was the case for the Chinese prescriptions I had previously outlined, the impetus forthese recent experiments was a simple inquiry into thepossible validity of a legendary folk remedy. Themechanism of some indirect action of Lentinan, perhapsfunctioning by way of the immune system, as the factorresponsible for observed inhibitions of neoplastic proliferation, might then be in accord with the concept, asinterpreted by Dr. Chihara of the National Cancer11Center, that "In Oriental medicine the fundamental principle, practiced since olden times, is to regulate thehomeostasis of the whole body and to bring the diseasedperson to a normal state, rather than to attack the focusof disease directly."Everyone has a good written command of English, albeit with the exception of Professor Kitagawa, the director, and Dr. Hamaoka, we must communicate-in-very-clearly-enunciated-short sentences. Sincemy appearance, or intrusion, we have all been embracingdictionaries, the secretaries carry conversation manuals,and our daily lunch-time seminars and Wednesday evening conferences are conducted in English, with only "occasional" lapses into Nihongo 0 narneba anata no tameni naru to omoimasu. A number of fourth year medicalstudents rotate through our laboratories on mandatoryone or two month "exposures to research." With them, Ienjoyed very special introductions to Japanese life. (Iwas told confidentially by a few, however, that just assometimes happens at Chicago, they didn't really want tobe there). One showed me a small ovoid doll, bearing arather fearful countenance, with a large moustache andtwo blank eyes. It represents the renowned Indian priestDharma, who introduced Zen Buddhism into China, inmeditation. It is traditionally purchased by hopefulpoliticians and by medical students who must take examinations. A wish is made as one eye is given a pupil bythe owner, and if the wish is granted, the remaining pupilis painted. Needless to say, following finals week thereare numerous half-blind Dharmas.It was explained that everyone at the medical school,is considered part of one family, a statement clearly mademanifest by the joyous, if Rabelaisian, bonen-kai("forget the last year") parties we have had. With thechallenge: sensei dozo, women attired in brightly coloredkimonos kneel down beside each of us, to pour continuously hot sake into wine cups, while offering a sharp slapon the back, and chattering garrulously. As the mostdistinguished professor joins our technicians and aides ontatami mats, high school songs are easily exchanged, inevitably to be followed as the night wears on by impromptu dances and erotic ballads. Such events wererepeated many times through the New Year holidays, adelightful welcome to a new season in Japan.At the Institute, my individual project involved an invitro exploration of the mode of immunosuppression of alow molecular weight protein derived from a cell-free extract of Ehrlich ascites tumor fluid. During experimentsyet in progress, I have ostensibly shown that while thissubstance permits "recognition" of a myeloma cell by alymphocyte, as measured by the mixed leukocyte reaction, it dramatically inhibits the effector phase of thisinteraction, prohibiting specific killing of the tumor cell.Resolving certain problems with this and other systems Iam now studying has occupied most of my time. But, asthe days grew warmer, dulling the memory of a frigidwinter that begs guidebooks to admonish the avoidanceof Japan in the snow, the pink and white plum blossomsof early spring gradually were replaced by splashes ofcherry and, in between ward rounds and test tubes, Imanaged to squeeze in a flower or two.12 Oh, this hectic worldThree whole days unseen,The cherry blossom!("Night growing late," Oshima Ryota)In 1224, Shinran Shonin initiated a new approach to"teaching the way to Heaven," founding one of the threemain branches of Zen Buddhism in Japan. Because of thegreat strength J odo Shin-shu soon thereafter secured inthe old Imperial capital of Kyoto, this sect was dividedinto Higashi (East)- and Nishi (West)-Honganji, withover ten thousand temples, now worldwide, under eachjurisdiction. If you walk one block directly east of themain entrance of the latter, past a long row of tightlyspaced houses of thatched roofs and wooden-lace fronts,and little shops that you must know exist in order to find,you might encounter a rather confused looking foreignerattempting to decipher the hira-gana over a market stall.For this past year, through the introduction of a psychiatrist friend spending her life in Japan, I have lived inHorinji-dera, a small family temple ofthe Nishi-Honganjischool. To awaken on festival mornings to the sound ofits gong and the odor of burning incense. To live to reachbodai-the supreme enlightenment. The two sons of theKawamura family speak English fairly well, serving as aconstant reminder of my travesty of their language, andprovided me with an approach to life here no "prolongedtourist" could otherwise hope to attain. Treasures for allseasons.It is a 45-minute train ride between Osaka and Kyoto,reduced to but ten minutes on the "bullet trains" of thenewly constructed Shinkansen. This time was spentpouring over books on the martial arts, haiku, and thephilosophy of gardens. Osaka is a commercial district alltoo reminiscent of Chicago and N ew York. Kyoto istwelve hundred years of a history and tradition dispersedin countless Buddhist temples and Shinto shrines; quaintnarrow roads lined with curio shops; open air marketsalong streams and wooded hillsides; and geisha recitalsand maiko in Gion. There is maple viewing on decoratedbarges on the Oi River in November, and cherry blossomviewing, stirring sake, in April. The orphean displays ofthe kotto and samisen; Bunraku puppet theatre; Nohdramas by torchlight at Heian shrine; and ukiyo-e,woodblock prints literally meaning "pictures of thefleeting world." Small children who timidly approachyou on the streets, shout "hello," "good-bye," and"baseball," then scatter. And those that stay try to talk,to express Nihon no furusato , the heart of Japan.The first few months I spent here were extremely cold,with only a space heater and a warming pan, fed by burning coals, suspended beneath my table, for warmth. Weoften formed a strange pair walking through the city, oneof the sons dressed in a thin, dark blue kimono andwooden clogs, and I in the less traditional, but decidedlymore practical, oversized woolen coat. I quickly accepted this, as well as the varieties of delicacy in food-the oblong pieces of raw fish, sushi and sashimi, thatmost of the uninitiated decline-and the agony of tryingto appear composed while squatting longer than ten minutes in formal position at a banquet. And of coursefinally, the beautiful and graceful kimono-clad women,prompting my acquisition of the "essential" Japanese.Fragrance fills Kyoto over all its twelve bridges,The gaiety of the spring light is heavily loaded with charmingflirtation.A cloudy brocade on her bosom and a round embroideredball from behind;Who says that this human world is competing for a slender.t?wars . (C. Vee)"There is one great difference [in Bunraku] betweenthe male and female puppets, for the latter, with one ortwo exceptions, have neither legs nor feet ... explainedby a Japanese authority as adding to their sex appeal. ...The head of a male puppet is fitted closely to its neck andis perfectly erect. The head of the female puppet is moreloosely fitted and protrudes forward a little." (A.C.Scott) In spite of this commentary, it is difficult to defineconcisely the contemporary role of women in Japan.Subsequent to World War II, the alacrity with whichdemocracy was introduced and an old morality severed,and even a women's liberation movement named, insuresthat it is constantly changing. However, wives are rarelyinvited to formal functions or dinners with businessfriends, a custom which was not altered during my stay.Wide Show: 11 p.m., an impetus for my securing a television set, is featured up to five nights a week, as the particularly expressive segments (especially Thursdays!) arebroadcast only in the Tokyo-Osaka region. They are livestrip shows. Medically, I was most interested in aspectsof population control. My initial exposure to this subjectfollowed the suggestion that I need not inquire in a hospital chart history whether or not a patient was on birthcontrol pills. The incidence of a regular practice of somemeans of contraception is extremely high, approaching60 percent among married couples. Yet, the sale of oralcontraceptives is banned, apparently because of governmental anxiety over possible deleterious effects withchronic use, as experienced during periods of unregulated sale of other pharmaceuticals in Japan. Similarly,the general use of the IUD (intra-uterine device) is prohibited. Most couples utilize the condom or periodic continence but, in a 1969 survey by the Mainichi Shimbun ofover 1000 representative married women asked "Whatmethod of contraception are you practicing?" , 13 percentanswered abortion. Indeed, this poll revealed that over20 percent of all married women terminate their firstpregnancy, with almost 50 percent in the 40-44 age groupconfiding at least one experience with induced, usuallyfirst trimester, abortion. Sixty-five percent then indicateda substantial resistance, in the form of physical andpsychologic anxiety, after the surgery, feeling that theyhad "done something wrong," or "felt pity for the embryo." I have found no indication that the official position of the government toward oral contraceptives or theIUD will soon alter. I can but wonder at the furthercourse of progress of women's rights, both legal and social.The priest of Horinji-dera explained that Zen, while ithas not sought to divest itself from the austerity of prolonged meditations, emphasizes the attainment of en- lightenment by the integration of the spiritual with everyday life, thereby awakening a higher power, enabling oneto make contact with "reality" itself. It is this ideologythat demands that the jutting rocks among the moss andwhite sand gardens of Kyoto and Nara provide a direction of entrance into communion with the universe, notsimple revelry in their beauty-to insure transcendenceover all that is illusory. It is this philosophy whichequates the results of a scientific procedure with the response to a prayer, and created akuyo ("reverence") ritefor the" human or animal corpses used for medical experiments [as well as for] the brushes thrown away by thepainter and calligrapher" (D. T. Suzuki). The abbot ofDaitokuji Temple, in the northwest of Kyoto, has placeda small wooden sign over the passageway to the garden.In kanji and English it suggests, "If you want to learn thetrue meaning of Zen, please take up a broom and rake thegrounds. "Walk three blocks in any direction from my home and alarge temple or shrine or park appears. I frequently spendtime in Japanese gardens, on a Sunday or a national holiday, gazing, and waiting to see if the "thought of nothought" had meaning. Then I'd return to Osaka, to thecancer wards of its thousand-bed hospital, to the research labs and animal rooms, to libraries filled with bothmedical journals and the histories of Chinese drug merchants, to the lounges crowded with medical students nodifferent from our own. If I had to select three pictures tobring back in an attempt to explain the spirit of Japan,they would have to be a pagoda against cherries inbloom, scores of people changing their shoes in unison,and a ripple in white sand. A quiet conflation of East andWest.We grudge life moving onBut we have no redress.I would become as thoseFirm rocks that see no change.But I am a man in timeAnd time must have no stop.("The impermanence of human life," Yamanoue Okura)Among these personal ramblings of my meeting withJapan and East Asia, I've tried to demonstrate a joy forthe land and its people, its institutions and advances andculture, and all that I have learned from them, and stroveto offer.I kneel at my deskAnd form the word * *;How easily it comesSesshin and enlightenmentAs Kyoto meets dawn.(J .C. L.)A member of The Pritzker School of Medicine class of1976, Mr. Laurence is spending his senior year in Asia asa research associate of the Institute for Cancer Research,Osaka University Medical School, while a scholar of theHenry Luce Foundation. He is now 22 years old."The Chinese ideogram for dai (great).13Jeffrey KantJoseph LockerBrian BergerBruce Wainer14 Florence Huang SheehanRoger TaylorConstantine AthanasuleasJohn Danielson Senior Scientific SessionTwenty-one senior medical students (Class of '75) presented reports of their research at the 29th Annual SeniorScientific Session, Friday, May 16, in the Frank BillingsAuditorium. Following each paper, the chosen discussant made brief comments, giving additional informationon the subject or raising questions. Each student wassponsored by a faculty member.The program was divided into four sections. Chairmenwere: Dr. Leon Goldberg, Dr. Leon Resnekov, Dr.Frank Newell and Dr. Edward Cohen. Members of thearrangements committee were: William Martin, chairman; Dr. Edwin Kaplan, Dr. John Schneider ('63) andDr. Martha Warnock.The Asymmetric Red Cell MembraneJeffrey A. KantSponsor: Dr. Theodore L. SteckDiscussant: Dr. Wolfgang EpsteinAn understanding of the detailed molecular organizationof a membrane requires an appraisal of the distribution ofcomponents at its two surfaces. To this end, I have usedimpermeable vesicles of normal (right-side-out) and inverted (inside-out) orientation to selectively examineeach surface of the human erythrocyte plasma membrane. Inside-out vesicles were generated by incubatingisolated erythrocyte membranes at low ionic strength;right-side-out vesicles formed instead if divalent cationswere present in the medium. I demonstrated that sialicacid, acetylcholinesterase, and NADase reside at the extracellular face of the membrane, as judged by their accessibility to exogenously added probes in intact cellsand right-side-out vesicles, and their lack of reactivity ininside-out species. Similarly, NADH diaphorase andbinding sites for cyclic AMP were found only at thecytoplasmic membrane surface. I conclude that thesecomponents show an absolute asymmetry in their topographic distribution.Also confined to the cytoplasmic surface was ahomogeneous class of high affinity binding sites forglyceraldehyde 3-phosphate dehydrogenase (G3PD),from which this enzyme was selectively released by certain glycolytic metabolites. In contrast, cytochrome c,another basic protein, bound weakly to both membranesurfaces and was not released by any metabolites. A systematic comparison of the adsorption behavior of thesetwo proteins indicated that the binding of G3PD to themembrane was not solely attributable to nonspecific electrostatic interactions. It is possible that a fraction oferythrocyte G3PD may be specifically bound to the innersurface of the membrane in vivo in a fashion which isresponsive to metabolic transients.Detection of a Tumor-associated Antigen ofASL-l Cells Which Fails to Undergo ModulationFlorence Huang SheehanSponsor: Dr. Edward P. CohenDiscussant: Dr. Theodore SteckThis study was designed to determine whether thymusleukemia (TL) antigens remain associated with the surface membranes of TL( +) cells which have undergoneantigenic modulation.TL antigens are antigens associated with the membranes of murine leukemia cells and with nonneoplasticthymus cells of certain strains of inbred mice. After exposure to TL antiserum, TL( +) cells gradually lose theirsusceptibility to TL antiserum and complement (antigenic modulation).To determine whether TL antigens remain, after modulation, with the surface membranes of ASL-l celis, aTL( +) murine leukemia, the cells are stained with TLantiserum followed by fluorescein-conjugated rabbit antimouse IgG. As an additional test, variable numbers ofcells are incubated with TL antiserum of known titerfollowed by retitration of the antiserum.Using direct fluorescent antibody tests, cells stainedbrightly throughout a ten hour period of incubation in TLantiserum even though they were no longer susceptible toTL antiserum and complement. However, modulatedcells failed to absorb the cytotoxic activity of TL antiserum, suggesting the presence of antibodies to a second antigen of TL( +) cells. Further studies by directextractions of the cells and analysis by polyacrylamidegel electrophoresis revealed the presence of a tumorassociated antigen of ASL-l cells not found on nonneoplastic TL( +) cells. It failed to undergo modulation. Theresidual presence of this antigen was insufficient to leadto cell lysis in the presence of specific antiserum andcomplement.Arrangement of DNA Sequences in Mitochondrial DNA from Yeat MutantsJoseph LockerSponsor: Dr. Murray RabinowitzDiscussant: Nicholas CozzarelliSaccharomyces cerevisiae (baker's yeast) is extremelysuitable for the study of mitochondrial biogenesis because it is easily biochemically manipulated and hasmitochondrial mutants. My studies and others haveshown that one group of mutants, the petites, are respiratory deficient as the result of substantial deletions inthe mitochondrial DNA (mtDNA). However, individualpetite mutants still retain some mitochondrial genes (likechloramphenicol resistance) that can be transmitted torespiratory sufficient strains in a cross. Unlike mammalian mtDN A, which consists of a homogeneous population of five micron circles, petite mtDNA consists of a Court CuttingDaniel MassFelix ChenRoss Lambert Arnold CalicaDorothy LeetDavid SchanzlinDavid Scollard15heterogeneous population of linear molecules. I developed improved techniques for mtDN A isolation andfound an increase in the overall length of the linearmolecules and some circular DNA molecules. Usingelectron microscopic and renaturation kinetic analysis, Ifound that the circles were simple multiples of a basicmonomer length, and in four strains the linear moleculeswere orderly polymers of the same DNA sequence arranged as tandem repeats in a regular head-to-tail fashion. When mtDN A from three other strains was denatured, it spontaneously renatured into unusual structuresby a first order process. Electron microscopic analysis ofthese structures, and of denaturation maps of the nativeDNA, indicated that the linear mtDNA molecules fromthese strains also consisted of a regular arrangement, butsurprisingly as a head-to-head, tail-to-tail arrangement ofthe circular monomer sequence (i.e., tandem inverted repeats). Thus, in spite of molecular heterogeneity, mystudies showed that each petite has its own unique genecontaining DN A sequence, which is a fragment of thetotal mitochondrial genome. This sequence is defined bythe circle monomer length but is generally amplified intolonger linear and circular molecules.The Uronic Acids of Heparins and Heparan Sulfates and the Correlation with BiologicalActivityRoger L. TaylorSponsor: J. Anthony CifonelliDiscussant: Dr. Reuben MatalonThe currently accepted structure of heparins and heparansulfates is that of a repeating disaccharide of glucosamineand either glucuronic acid or iduronic acid. The biological activity of these compounds is related to severalparameters, but the importance of the uronic acids ispoorly understood.In this study, an attempt is made to correlate the ratioof these uronic acids with the biological activity of heparin and heparan sulfate preparations. Heparin sourceswere beef lung and mucosa, hog mucosa, whale, andJames Kessel William Lee16 clam. Heparan sulfates were from beef lung, hog mucosa, and human umbilical cord. The iduronic andglucuronic acid contents were determined by measuringthe amounts of 3 H recovered in glucose and idose whenthe polymers were coupled with a carbodiimide and carboxyl reduced with sodium [3H] borohydride. Such reduced heparin retained no anticoagulant activity and nolipoprotein lipase clearing activity.Iduronic acid varied from 50 to 90 percent of the totaluronic acid in heparins and from 30 to 55 percent in heparan sulfates. Beef and hog heparins with otherwise similar parameters of molecular weight and sulfation appeared to reveal a relationship between iduronic acid andanticoagulant activity, although whale and clam heparinsshowed no such relationship. The iduronic acids of thelatter compounds were previously shown to be concentrated closely together on the molecule. Conversely,heparan sulfates have iduronic acids widely dispersedalong the molecules and have very low anticoagulant activity despite having as much as 55 percent acid in somesamples.The carboxyl groups of uronic acids of heparin andheparan sulfates are thus vital to the function of thesepolymers. A high proportion of iduronic acid appears tobe necessary for anticoagulant activity and maximal effects on activity are associated with close proximity ofthese units along the length of the molecule.Parameters of Cellular Immunity in Lung CancerPatients during Irradiation TherapyBrian BergerSponsor: Dr. Nicholas GrossDiscussant: Dr. Edgar M. MoranAn intact immune system has been correlated with bettersurvival in patients with malignant tumors. However,cell mediated immunity is depressed in the majority ofcancer patients. Cellular immunity can be further depressed by radiation. The present study examined theeffect of high dose radiation to the thorax on cellularimmunity of lung cancer patients undergoing irradiationDennis Siamon Wai-Kwan Yungtherapy. Half of the patients were randomly assignedto receive a single BCG treatment prior to irradiationtherapy in an effort to minimize the expected irnmunosuppression.All patients were newly diagnosed cases of bronchogenic cancer by tissue biopsy or cytology. They werefree from metastatic disease outside of the thorax at thebeginning of the study as determined by appropriatescans and clinical examination. The parameters of cellular immunity found to be most reliable were in vitrolymphocyte stimulation assays using phytohemagglutinin(PHA), a non-specific mitogen, in three log concentrations, and PPO, streptokinase/streptodornase, specificrecall antigens.PHA stimulation resulted in a mean 3H-thymidine uptake of 18,936 cprn/Iu" lymphocytes prior to irradiationtherapy. This was reduced significantly after 2,500 to5,000 rads to 5,451 cpm/In" lymphocytes. Concurrently,the peak lymphocyte stimulation by PHA occurred at atenfold higher concentration, suggesting decreased sensitivity of the lymphocytes. The mean lymphocyte countwas depressed from 2,308/mm3 prior to irradiation to743/mm3 during irradiation therapy. A subgroup of patients studied three to four weeks after the completion ofa full course of irradiation therapy of 5,000 to 6,000 radsdemonstrated a rebound by PHA stimulation to a meanof8,575 cpm/IO't lymphocytes compared to 4,738 cpm/IO"lymphocytes during irradiation therapy. Compared to thepre-radiation value of 15,284 cpm/l O" lymphocytes, therebound was not complete.These parameters quantitate a severe depression ofcellular immunity during irradiation therapy, and suggesta gradual return of immune function toward pretreatment levels during the weeks following irradiation.The BCG treated group did not differ significantly fromthe control group. Further studies using more extensiveBCG immunization both prior to and during the course ofirradiation seem warranted. BCG immunotherapy mustbe performed cautiously in immunodepressed patients. because of the greater risk of systemic BCG infection.Immunotherapy as an adjuvant treatment to known immunosuppressive therapy, such as irradiation, remains aviable but unproven concept for the oncologist.Richard Champlin A New Operation for Transposition of theC reat ArteriesConstantine L. AthanasuleasSponsor: Dr. C. E. AnagnostopoulosDiscussant: Dr. Rene ArcillaTransposition of the great arteries occurs in one of 4,500births and is a major cause of cyanotic congenital heartdisease. Untreated, it is uniformly fatal; death usuallyoccurs within the first six months of life. The creation ofan atrial septal defect, by means of the Blalock Hanlonoperation or the Rashkind balloon septostomy (followedlater by corrective surgery), is the accepted mode oftherapy. The atrial baffle operation, though it carries alow initial mortality (10 percent), is plagued by such latecomplications as dysrhythmia, venous obstruction, andtricuspid insufficiency; five-year survival followingsurgery has been 60 percent.Our new operation for transposition is a directanatomic correction of the defect. It involves switchingthe aorta and the pulmonary artery. In the past, such anapproach had been unsuccessful since the coronary arteries must also be reattached to receive oxygenatedblood. If, however, an incision is carried beneath thecoronary ostia but above the aortic value, the coronariesremain attached to the aorta as it is anastomosed by microsurgical techniques to the proximal pulmonary artery.A length of coronary artery, from the aortic root to thefirst branch, is free to be moved. lfthis distance is greaterthan the distance the coronary ostium must be movedonto its new site on the pulmonary artery, a switch isconsidered possible. Measurements of 58 autopsy specimens indicate that in 26 the coronary anatomy is favorable. In 21, one vessel could be switched with no tensionand in II the anatomy is unfavorable .The operation has been carried out in minipigs (10 lbs.)under deep hypothermia and circulatory arrest. Since theinitial anatomy is normal, the operation creates an animalmodel of transposition. Forty such procedures have beendone; of the last nine, four have survived up to six hours.Creation of an ASO or VSO aids in mixing the bloodfollowing the switch, but because the right ventricle isunprepared to undertake systemic pumping suddenly,it fails acutely. Pulmonary artery banding for a fewweeks prior to surgery should adequately prepare theright ventricle. This will be the next phase of this investigation.The operation described is the first that restores normal anatomic continuity in this disease. It totally eliminates the existing problems of the physiologic atrial baffleoperation which switches the input of blood, and is associated with so many mechanical problems as a result.The need for a new operation for transposition is themost urgent challenge in congenital heart surgery.Switching the aorta with its coronaries and the pulmonary artery is the most promising answer to this challenge.17Immunochemical and Biological Properties ofAntibodies Against Opioids .Bruce H. WainerSponsor: Dr. F. W. Fitch ('53)Discussant: Dr. R. M. Rothberg ('58)Three opioid derivatives-morphine-6-hemisuccinate,codeine-6-hemisuccinate, and hydromorphone-6-carboxymethyloxime-were synthesized and covalently attached to bovine serum albumin forming immunogenichapten-protein conjugates. Antibody responses measuredby radioimmunoassay showed increases in titer andavidity following repeated immunizations. The specificities of the antisera, as measured by competitive inhibition techniques, demonstrated that the ranges ofimmunoreactivity of the antisera were different and corresponded closely to the structure of the respectiveimmunizing haptens. The avidity and homogeneity ofhapten-antibody interaction were studied under steadystate conditions and under conditions of hapten-antibodydissociation. Results of these studies together with results of competitive inhibition data suggest that antiopioid antisera are heterogeneous with respect to theirbinding affinities and with respect to their reactivity toward restricted domains of the opioid molecule. Antimorphine antiserum was shown to be biologically activeill vitro in that it both prevented and reversed the depressant action of morphine on the electrically-induced contractions of isolated guinea pig ileum preparations.Further, actively immunizing a rhesus monkey againstmorphine specifically antagonized, in a dose-dependentfashion, those actions of heroin that reinforced drugself-administration. These studies have provided severalspecies of antisera for sensitive measurements of opioidsin biologic fluids. Such reagents may also be useful in thestudy of opioid-receptor interactions ill vitro and possiblyin vivo,Material Clearance, Placental Transmission andNeonatal Effects of Meperidine AdministrationDuring ParturitionJohn DanielsonSponsors: Dr. Richard Rothberg ('58) and Dr. ChrisRiegerDiscussant: Charles SchusterSerial serum samples from 19 women rece rvm gmeperidine during labor and the umbilical cord sera oftheir normal full-term infants were assayed formeperidine by radioimmunoassay. The specificity of thereagent antiserum was assayed by the competitive inhibition of 3H-meperidine binding by different concentrations of unlabeled major meperidine metabolites andother drugs which may have been present in the maternalserum. The concentration of two of the major metabolites, opiates, and tranquilizers required to inhibit binding18 of 3H-meperidine by 50 percent showed that these compounds minimally reacted with the reagent antiserum,and would not interfere with the assay. However,normeperidine interacted sufficiently to significantlyalter the results. Hence, the final levels of meperidinewere reduced by the appropriate amount to account forthe normeperidine effect. Initial meperidine clearanceafter intravenous administration was more rapid thanafter intramuscular administration. After two hours, themetabolism appeared to follow similar first order kinetics(half-life approximately four hours). Placental transferappears to be effected by differential solubilities in maternal serum and lipid containing tissues. The mean ratioof cord to maternal serum concentrations was 0.8 ± 0.2(± I S.D.) nanomoles/ml of serum. Control infants andinfants of mothers who had received meperidine withintwo hours of birth had little or no respiratory suppression. When the meperidine was given more than twohours prior to delivery, variable degrees of fetal depression, (changes in fetal heart rate during labor, the appearance of meconium stained amniotic fluid, time to spontaneous respiration and apgar score) could be observed.The fetal depression could not be related to maternaldose, route of administration, or umbilical cord serumconcentration. This suggests that factors other than adirect effect on the infant's respiratory centers playa rolein the observed depression. Although all the infants weredischarged with their mothers in apparent good health,evaluation of the child's ability to function in school isnecessary before the observed respiratory depressioncan be dismissed as being of no significance.New Diagnostic Technique and Model for anOccult Tracheo-esophageal FistulaCourt B. CuttingSponsors: Drs. J. Laurance Hill and Brian R. J.WilliamsonDiscussant: Dr. Robert L. ReplogleTrans-systemic or short-circuiting intrasystemic fistulaeare life-threatening and require surgical intervention.Representative of these often occult entities is the"Netype " tracheo-esophageal fistula, for which no simple and reliable diagnostic procedure is available. After areview of the embryology, anatomy, clinical symptomatology and of the current diagnostic techniques forthis anomaly, this report introduces a new laboratorymodel and presents a successful diagnostic solution.In eight of ten canine experiments, patent tracheoesophageal fistulae were successfully constructed. Onlythree [of the eight], however, satisfactorily conformed tothe ciinical configuration of the "Nvtype," which required creating a pedicle-tube by primary rotation of anoblique flap from the anterior, non-mobilized esophagus.This surgical model was then utilized to test and provethe reliability of a new, simple and less invasive technique for documenting the presence of fistula. A speciallydesigned, esophageal appliance, which isolates an intraluminal segment, has been produced and avoids thedangers of airway instrumentation. All of the pedicletube fistulae were demonstrable by the technique utilizing the latest model of this appliance.The physical characteristics of the tube and technique,a clinical protocol for application, possible complicationsand specific as well as general implications are discussed.A Computer Model for the Response of theRetinal Ganglion CellArnold Barry CalicaSponsor: Dr. Harry FozzardDiscussant: Dr. Paul GrobsteinIn an elegant series of experiments, Kuffler ':" recordedand characterized the patterns of electrical discharges ofthe eat's retinal ganglion cell in response to light stimulation of the retina. Using this experimental model, thenotions of receptive field, "on" response, "off" response, and "on-off" response are defined (vide.'). Important observations by Kuffler are the following: (1) apparent antagonism between stimuli at the center andperiphery of a receptive field; (2) change in the size of areceptive field as a function of the intensity of the exploring beam; (3) variation in the character of a response as afunction of the size, intensity and location of thestimulus.Utilizing Kuffler's data and interpretations, it has beenpossible to define a family of mathematical models whichwill completely reproduce his experimental observations.This family of models has been embodied in a computerprogram which will allow one to simulate a larger set oflight stimuli than that employed by Kuffler.An additional use for the family of models describedabove is to provide criteria for the design of further experiments which may be performed in the animal system.An interesting way to do this is to specify a set of experiments which most severely restricts the class of modelswhich will encompass the data to be generated. Using thecomputer model of the Kuffler data, several such sets ofexperiments have been constructed.Fatty Acid Analysis of Human Retinal PigmentEpitheliumDaniel P. MassSponsor: Dr. Frank W. NewellDiscussant: Glyn DawsonThe retinal pigment epithelium both stores andisomerizes vitamin A and provides vitamin A to the opsinI. Kuffter, S. W., "Discharge Patterns and Functional Organizationof the Mammalian Retina," Journal of Neurophysiology, 1953, 16, pp.37-68.2. Kuffler, S. W., "Neurons in the Retina: Organization, Inhibitionand Excitation Problems," Cold Spring Harbor Symposium in Quantit ative Biology, 1952,28, pp. 281 ff. proteins of the outer segments of the sensory retina. Anderson and co-workers have shown that the phospholipidcomposition of the rod outer segment of a number ofmammals is remarkably similar. Inasmuch as the pigmentepithelium phagocytizes the rod outer segments andplays an important role in vitamin A metabolism, we believe it to be of interest to study the lipid composition ofthe retinal pigment epithelium in man.In the phospholipid aliquot we found thephosphatidyl-ethanolamine, phosphatidylserine andphosphatidylcholine have a higher percentage ofarachodonate (20:4). The docosahexaenoate (22:6) concentration is in the same range as found in bovine and ratrod outer segments. In the neutral lipid separation, a highconcentration of arachodonate and moderate concentration of docosahexaenoate was found in the free fatty acidportion.The fatty acid composition of the human retinal pigment epithelium has not been studied previously, although the composition of the outer segments is reasonably well known. If the pigment epithelium phagocytizesthe outer segment disks, and recycles the fatty acids andvitamin A, then, as we see, the unsaturated fatty acidconcentration in the phospholipids would be similar tothat in the rod outer segments.The Glaucoma Water Provocative TestDorothy LeetSponsor: Dr. Terry ErnestDiscussant: Dr. Walter H. Stern (,70)The diagnosis of chronic simple glaucoma is evidentwhen intraocular pressure is markedly elevated and thereis visual field loss and cupping of the optic nerve. However, a goal of ophthalmologists is to detect glaucomabefore such irreversible damage occurs. Tonometry andtonography may be normal during a single examination ofglaucomatous eyes. Therefore, "provocative tests,"such as the water-drinking test, have been designed toelicit abnormal reactions from suspicious eyes.The water-drinking tests of 232 eyes of 117 patientswith histories or examinations suspicious of glaucomawere analyzed. These patients, tested at McPhersonHospital, Durham, North Carolina, between January1969 and December 1972, were divided into "glaucomatous" and "non-glaucomatous" groups according todiagnoses made in follow-up periods of at least twelvemonths.Although the test did prove to have some diagnosticvalue, the results were poor. Only 22 percent of"glaucomatous" eyes had positive tests and 3 percentfalse positives occurred in the "non-glaucomatous"group. Variation of the criteria for positive tests, such asaltering the pressure rise needed and/or setting peak allowable pressures did not increase the reliability of thetest results. Post-test tonography was also not a gooddiagnostic tool. Data from patients in our "glaucomatous" group (including intra-ocular pressures. water-19drinking tests, and tonography, the distribution of pressure changes during the test, and ranges and means ofresults) were comparable to those of other studies. Datafrom our "non-glaucomatous" patients, however, werequite different both from that of our glaucoma group andfrom that of normal control groups of other studies, indicating that many of these patients may later be diagnosedas having the disease. Therefore, any patient deemedsuspicious enough to have a provocative test forglaucoma should have close follow-up and educationabout the disease.We feel these results prove the water-drinking test tobe an unreliable aid in the evaluation of glaucoma suspects.A Model of Experimental Retinal andChoroidal EdemaFelix ChenSponsor: Dr. Walter Stern ('70)Discussant: Dr. Jack de la TorreA reproducible and quantitative model for the study ofexperimental retinal and choroidal edema secondary toconcussion injury of the eye was developed. Animalsused in this model were weight-matched rabbits. An airpistol firing specially made brass pellets was used toinflict the trauma and each firing was electronically timedto monitor reproducibility of pellet velocity. The projectile velocity which was used in our model allowed maximal choroidal and retinal edema with minimal choroidalrupture and subretinal hemorrhage. The lesion thus produced was visualized by indirect ophthalmoscopy as itdiminished in size and resolved as an atrophic glisteningwhite area over a period of roughly five days. Histologicpreparations revealed that the retina was detached byfibrinoid staining material in the area opposite the pointof impact and that the choroid in that area was thickened.At day five, end-stage histologic changes were characterized by the loss of pigment epithelial cells and outerlayer receptor nuclei and by the proliferation of pigmentepithelial cells.Methods for quantitating this lesion involved the use ofdry/wet weight ratios as an expression of percentswelling, and radioactively labelled Na24 and JI25 albumin. Dry/wet weight ratios indicated that the lesionreflected not merely the presence of extracellular fluid,but also of choroidal stasis and hemorrhage. That thisshould be was not surprising in view of the rich vascularity of this region.Preliminary work indicated that there was an acuteincrease in NaH (a 100 to 200 percent increase in countsin the traumatized eyes as compared to the controls) onehour after trauma, followed by a rapid fall. So that at 24hours there was essentially no difference in extrudedNa24 between control and traumatized eyes. Similarly,there was an acute rise in fl25 albumin (about a 150 percent increase in counts in the traumatized eyes compared20 to the controls), followed by a less precipitous fall than inthe case of Na24. Thus at 24 hours, there was still a 100percent increase in counts in the traumatized eyes compared to controls. The persistence of the lesion clinically,as contrasted with the rapid fluctuations in extruded ions,was apparently due to necrosis of tissue and intracellularswelling.With this model of concussion injury, not only can thedynamics of retinal and choroidal edema be studied, butthe efficacy of various drugs, such as corticosteroids anddimethyl sulfoxide, as treatments can be evaluated. Thisis of great clinical significance, since a large proportion ofconcussion injuries to the retina in humans results inpermanent visual loss.Moreover, it may be that other situations in whichchoroidal effusion results in retinal edema, such as ocularhypotony, encircling rod retinal detachment proceduresand idiopathic retinal detachments in hypertension, mayrespond in a similar fashion therapeutically as retinaledema secondary to trauma-induced choroidal effusion.If this is so, then drugs useful in treating our model lesionmay prove beneficial in treating other retinal and choroidal edemas of whatever etiology.Early Receptor PotentialDavid J. SchanzlinSponsor: Dr. Albert PottsDiscussant: Dr. John L. TrimbleThe electroretinogram is a light induced action potentialoriginating in the retina. In 1964, Brown and Murakamidescribed a potential with little or no detectable latencypreceding the a-wave of the electroretinogram. This potential, the Early Receptor Potential (ERP) is biphasic inform.Since 1964, numerous workers have attempted tocharacterize this potential. Their results show that theERP has retinal and pigment epithelial components.There is good evidence that the retinal component of theERP is a function of light induced changes in the visualpigment molecules. There are reports that the pigmentepithelial component is related to melanin, a nonvisualpigment.Early work in our laboratory showed that the ERPfound in some clinical electroretinograms could not bereproduced if the recording electrodes were carefully andproperly shielded. It has been reported that the ERP isresistant to prolonged anoxia and that it is not tissuespecific as it can be recorded anoxia and that it is nottissue specific as it can be recorded from frog skin, frogiris, and green leaves. These facts led us to believe thatthe ERP could well be a stimulus artifact.Using enucleated frogs' eyes, a bright light stimulus,and a well shielded system, we performed a series ofexperiments designed to substantiate the reality of theERP. Our results show that the ERP is indeed a reproducible response stemming from the retina-pigmentepithelial complex.Computer-Aided Analysis of theElectroretinogramRoss LambertSponsor: Dr. Frank W. NewellDiscussant: Dr. Karl J. Fritz ('71)The electroretinogram (ERG) is a summation of voltagechanges, measured across the eye, in the presence of anadequate light stimulus. The computer allows us effortlessly to summate large numbers of records and to compute many relationships which formerly would not havebeen found because of the laborious nature of the tasks.Fine details in waveform may be distinguished throughsummation and noise reduction techniques, which in thepast were never noticed.Studies on the photopic (light-adapted) ERG havebeen markedly aided by the computer. The maxima andminima of each wave are determined, along with the latency and amplitude of the response. Area analysis of thea-wave and b-wave portions of the ERG is easily performed. These techniques allow us to make on-line comparisons between our patients and the standards we haveestablished in testing normal subjects.New processing techniques for the ERG have comeinto being due to the rapidity with which the computerworks. Projection of waveforms onto vector spacesspanned by orthogonal functions has been valuable forboth smoothing and characterizing the response. Fourieranalysis, which uses sines and cosines as a basis of itsvector space, is most commonly used, but Chebychevand Legendre polynomials have advantages in certainsituations and are also used. These functions allow anefficient representation of waveforms.Work is in progress which is attempting to relate expansion coefficients, changes in experimental conditions,and disease states. Parameterization of waveforms is oneof the more promising areas for the future analysis ofocular disease.Kidney Transplantation in Rats without Evidenceof Cellular Immune Response: Effects of SpecificImmunologic TreatmentDavid M. ScollardSponsor: Dr. Frank Fitch ('53)Discussant: Dr. Frank StuartAllogeneic transplantation rapidly stimulates a vigorousspecific cellular immune response in normal recipients.This response results in rejection of the graft. Aftertransplantation of Lewis x Brown Norway (LxBN)Flkidneys in inbred Lewis recipients, azotemia and histologic evidence of graft rejection are noted within fivedays, and recipients totally dependent upon the allograftfor renal function survive for only 10 days. Previousstudies suggest that the allograft stimulates recipientlymphocytes from both thymus-derived (T cell) and non- thymus-derived (non-T cell) populations to becomecytotoxic effector cells detectable in vitro.Intravenous administration of allogeneic spleen cellsand hyperimmune alloantiserum to a recipient at the timeof transplantation will induce functional tolerance to thegraft without preventing the initial development of a vigorous cytotoxic response by T cells and non-T cells, detectable in vitro shortly after transplantation. Non- T effector cells are present in these "tolerant" recipients formany months.In the present experiments, adult, male Lewis rats received a single injection of 5 x 107 LxBN spleen cellsintravenously, followed by 1 ml of hyperimmune Lewisanti-BN antiserum 24 hr. later. Ten days later theseLewis rats were bilaterally nephrectomized and given asingle LxBN kidney. Urine output and blood urea nitrogen concentrations were monitored, and spleen cellswere tested for cytotoxicity in vitro at various intervalsafter transplantation. Recipients treated ten days prior totransplantation developed no clinical signs of rejection orof impaired renal function, and had no evidence of diminished lifespan. Furthermore, lymphocytes from theserecipients expressed no significant cytotoxicity of anykind in vitro at any time after transplantation. No othertreatment regimen has so completely and specifically inhibited the cellular cytotoxic reaction of adult animals toan allograft. This alteration of the normal cellular immune response is a provocative finding which has farreaching implications regarding mechanisms regulatingcellular immunity to allogeneic and malignant tissues.N- Terminal VH Sequences of Idiotypically Related IgMA IgGK Paraproteins from an IndividualMyeloma PatientJames W. KesselSponsor: Dr. John E. HopperDiscussant: Dr. Edward CohenExamination of two paraproteins (an IgMA and an IgG K)obtained from the serum of a patient with malignant lymphoma of the Waldenstrom's type revealed the presenceof very similar idiotypic determinants associated with theYH regions of the /..t and y chains. Amino terminal sequence analyses were performed on the Hand L chainsof these paraproteins. The N-terminal 41 residues of theK chain belonged to the YKIII subgroup, and the lightchains derived from the IgMA revealed a blockedN-terminus characteristic of A chains.Comparative sequence analysis of the I.L and y chainsindicated that, although both possessed an unblockedN-terminal glutamic acid, the respective Y H regions belonged to separate subgroups. The N-terminal 20 residues of the I.L chain reflected the YHIII subgroup, and they chain sequence demonstrated the unblocked Y HI pattern. These findings are in contrast to the serological evidence that the IgMA and IgGK proteins appeared to sharevirtually identical Y u-associared idiotypic determinants.21The data suggest that the N-terminal and hypervariableportions of the V H region may be under separate andindependent genetic control.Clonal Restriction of the Immune Response toPhosphorylcholineWilliam M. F. LeeSponsor: Dr. Donald Rowley (,SO)Discussant: Dr. John E. HopperCertain of the plasmacytomas that are artificially inducedin Balb/C mice produce IgA myeloma proteins whichhave antibody activity to the compound phosphorylcholine. Three of these, the TEPC-15, the MOPC-167and the MCPC-603 myeloma proteins, differ in their antigen receptor sites and can be differentiated usingspecific antireceptor antibodies (ARA). Immunization ofBalb/C mice with a vaccine of D. pneumoniae R36A orwith the hapten p-azophenylphosophorylcholine (PC)coupled to various protein carriers, such as Keyhole limpet hemocyanin (KLH) and Salmonella flagella (FLA),induces a splenic plaque forming cell (PFC) response tophosphorylcholine. The plaques specific for phosphorylcholine are produced by complement mediated lysis ofPC coupled sheep erythrocytes (PC-SRBC). The response to these phosphorylcholine antigens appears to beexclusively of the IgM class since multiple exposure toantigen, the use of adjuvants or the involvement ofthymus-derived (T) lymphocytes (in the response toPC-KLH) does not elicit splenic IgG PFC's or IgG antibodies in the serum. ARA directed against theTEPC-15 myeloma protein (anti-TEPC-15) inhibits theformation of plaques to phosphorylcholine by the splenicPFC's of immunized mice. Furthermore, anti-TEPC-15suppresses the induction of the immune response by antigen. These effects are specific since anti-MOPC-167and anti-MGPC-603 have no effect on plaque formationor on the induction of the immune response, andanti-TEPC-15 has no effect on the response to the unrelated trinitrophenyl hapten (TN P).From these results, it is concluded that Balb/C micepossess a highly restricted number of bone marrowderived (B) cell clones capable of responding to phosphorylcholine immunization, and that the cells of theseclones have surface immunoglobulins with receptor sitesfor phosphorylcholine that are very similar, if not identical, to that of the monoclonal IgA myeloma protein,TEPC-15.Effects of an Interferon Inducer (Poly I:C) on thePathologic Responses to a Murine leukemiaVirusDennis J. SlamonSponsor: Winston AndersonDiscussant: Dr. Elliott KiefTThe interferon mediated host cell defense system was22 first described 18 years ago. Since that time, interferonand interferon inducers have been used prophylacticailyand therapeutically against a broad spectrum of acuteviral infections in experimental animal models. This research investigates the effects of an interferon inducer onthe pathologic response patterns to a murine leukemiavirus (MEV). This virus, first described by Dr. WernerKirsten, is capable of eliciting two pathologic responsepatterns in Wistar-Furth rats. The acute response is amarked hemolytic anemia which is accompanied bysplenomegaly and extramedullary hematopoiesis illustrated by an extensive proliferation of basophilic erythroblasts in the liver and spleen as well as the bone marrow. The hemolytic syndrome and accompanying"erythroblastosis" is uniformly fatal within 12 days afterhigh titer virus challenge in neonatal animals. If smallerdoses are given to three week old animals, they develop afatal undifferentiated malignant lymphoma.Using the interferon inducer, polyinosinicpolycytidylic acid (poly I:C), the acute response wascompletely inhibited. None of the infected animals developed the hemolytic syndrome, irrespective of hightiter virus challenge. Control animals all responded withthe hemolytic syndrome and erythroblastosis. Studies ofthis response revealed that the hemolysis seemed to require complete reproduction of the virus in thehematopoietic tissue and that those cells most prolific inviral reproduction, (i.e., erythroblasts and megakaryocytes,) were those most affected by the hemolytic syndrome, (i.e., erythrocytes and platelets.) The erythroblastosis was shown to be an erythropoietin-dependentcompensatory response to the hemolytic anemia ratherthan a direct erythroproliferative effect of the virus. Introduction of an interferon inducer inhibited viral reproduction in the hematopoietic tissue as evidenced by electron microscopic and viral bioassay studies, thus circumventing the acute response to MEV. However, theseanimals went on to manifest the oncogenic response tothe virus and all succumbed to undifferentiated malignantlymphomas. Studies of these animals revealed that therewas no evidence of virus or viral replication in the malignant tissue. Also these animals were shown to respond topoly I:C injection with circulating interferon levelsknown to be inhibitory for viral replication throughout theperiod during which the malignancy was developing andprogressing. This evidence was taken to indicate thatviral replication was not necessary for malignant transformation of lymphoid tissue in this model. Since interferon does not inhibit viral attachment to, penetration of,or uncoating-unsheathing within the cell, but does inhibitreadout of viral messenger RNA and thus synthesis ofviral protein; it appears that transformation may be occurring somewhere between viral attachment and complete readout of viral messenger. Therefore, the hemolytic response to MEV, which seems to require viral replication, can be averted with induction of the interferonsystem; whereas, the oncogenic response to MEV,which seems independent of viral replication, is unaffected.Glioblastoma: Induction of a Reproducible, Autochthonous Tumor in Rat Brains with MurineSarcoma VirusW.-K. YungSponsor: Drs. Nicholas Vick and Melvin GriemDiscussant: Dr. Donald Pearson (' 59)Autochthonous experimental brain tumors can be induced by chemical carcinogens and by both DNA andRNA viruses. The viral models, especially those usingthe oncomaviruses such as Avian Sarcoma Virus (ASV),have been studied extensively in several species. Intracerebral inoculation of another oncomavirus, the Kirsten strain of Murine Sarcoma Virus (Ki-MSV), notheretofore studied for brain tumor induction, has yieldeda glioblastoma-like tumor in Wistar/Furth rats. As inASV tumors, there was no viral replication. The tumorswere identical in all animals; yield was 100 percent. Tenday postnatal rats were inoculated with 0.02 cc (1.6 x104FFU) Ki-MSV and were sacrificed when symptomatic on the 26th day. The tumors were large and hemorrhagic, and composed of anaplastic glioblasts and astrocytes, which were invasive of the adjacent brain parenchyma. A striking feature, rarely observed in other experimental gliomas, was proliferation of the microvasculature. Endothelial cell mitoses were abundant. With theelectron microscope, tumor capillary walls were found tocontain numerous complete gaps. In addition, abnormalblood-bearing channels, completely devoid of endothelium, were formed by the neoplastic astrocytes.Both perfused and immersion-fixed tumors were studiedby light and electron microscopy to assess the distribution and permeability of the abnormal endothelial andastrocyte-formed blood channels.This reproducible and rapidly induced tumor should beof value in therapeutic studies because of its similarity tohuman glioblastoma, and provides an excellent model tostudy further brain tumor microvasculature. Studies on the Composition of Adjuvants whichSelectively Enhance Delayed Type Hypersensitivity to Lipid Conjugated Protein AntigensRichard ChamplinSponsor: Dr. Robert Hunter ('65)Discussant: Dr. Robert W. Wissler ('48)Hen egg albumin (HEA), heavily conjugated withdodecanoic acid (0- HEA), stimulated sustained delayedtype hypersensitivity (OTH) specific for HEA withoutdetachable antibody formation in guinea pigs. An oil-inwater emulsion, containing purified BCG cell walls attached to the oil drops, was found to be a very effectiveadjuvant for enhancing DTH to O-HEA, but not toHEA. Animals immunized with D-HEA in the BCG cellwall emulsion produced skin test reactions 2.4 em indiameter when challenged with HEA 21 days after asingle immunization. Control animals immunized withD-HEA in saline produced skin reactions lcrn in diameter to similar challenge. Neither group of animals produced detectable antibody to HEA or D-HEA. Theemulsion had no adjuvant effect if the BCG cell wallswere suspended in the aqueous phase and not attached tothe oil droplets. Dodecanoic acid conjugated Salmonellatyphi organisms could be used in place of the BCG cellwalls to produce effective adjuvant preparations.Freund's complete adjuvant and other water-in-oil emulsions, however, were found to be ineffective adjuvantsfor enhancing the degree of DTH produced by D-HEA.Experiments with autoradiography demonstrated that effective adjuvant preparations promote the localizationand retention of both 125I-labeled O-HEA and125I-labeled BCG cell walls in the paracortical area oflymph nodes where they are in close proximity to many Ttype lymphocytes which proliferate in the induction ofDTH.SENIOR SCIENTIFIC SESSION WINNERSTwo prizes were awarded at the Medical Alumni Banquet on June 12.The Medical Alumni Prize for the best oral presentation was awardedto Joseph D. Locker. Dr. Locker is taking his residency in Pathology atThe University of Chicago.The Catherine L. Dobson Prize for the best oral presentation by anon-Ph.D. student was awarded to Felix Chen. Dr. Chen is taking hisresidency in Medicine at Mt. Zion Hospital in San Francisco.Residency Assignments-1975All 91 senior medical students who participated in theNational Intern and Resident Matching Program thisyear were accepted by hospitals of their choice. Fortytwo seniors were granted their first choice, 20 their second choice and eight their third choice. The remainderwere matched to the hospital of their fourth choice orhigher. All began their residency assignments July 1.Three married couples who participated in theNIRMP secured their postdoctoral clinical appointmentsprior to the actual matching process in accordance withN I RMP guidelines. One of these women was in the classof 1974 but had postponed her residency for a year.The class of 1975, with 107 graduates, was the largestin the history of the Medical School. Of the 11 seniorswho did not participate in the NIRMP: Two will complete their M. D. requirements at the end of the SummerQuarter 1975 and then begin their residencies; one willpostpone his residency until he completes his Ph.D.studies; one will do a postdoctoral fellowship in ClinicalPharmacology before beginning a residency; one is inEngland with her husband, a postdoctoral Fellow, andplans to postpone her residency for one year; and six willbe in special residency programs.This is the first year that "free standing" internshipsare no longer accredited. All first year postdoctoral clinical appointments are now designated as residencies.There are three types of first year residencies:"categorical" (analogous to straight internships in thepast), "categorical" or "diversified" (analogous tomixed internships in the past with the major componentin one clinical discipline), and "flexible" (similar to rotating internships in the past). In this summary, these newdesignations for the first year residencies are employed.Of the 91 students who received their residency appointments via the NIRMP, 88 percent (80) received appointments in residency programs which filled all theirpositions in the N IRMP. Similarly, of the 75 hospital units where our students began their residency programsthis July, 87 percent (65) filled all of their positions in theNIRMP.The 104 students in the graduating class who will begintheir residencies in 1975-76 are distributed among thevarious clinical disciplines as follows: Almost one-half ofthe class will be in internal medicine (46); another 17 willbe in surgery, including two in orthopedic surgery. Thedistribution by clinical disciplines is as follows:AnesthesiologyFamily PracticeFlexibleInternal MedicineNeurologyo bs tetric s-Gynecolo gyOphthalmologyPathologyPediatricsPsychiatryRadiologySurgeryOrthopedic Surgery 1254629431131152Total 104"It is noteworthy that all of the students who participated in the NIRMP were matched," says Joseph Ceithaml, Dean of Students. "This is especially remarkable inthe light of the fact that 7 percent (803) of all studentsfrom U.S. medical schools in the NIRMP were notmatched and the fact that 46 of our students sought residencies in internal medicine where 88 percent of allavailable residencies in the United States were filled inthe NIRMP in 1975. It is a testimonial to the combinedefforts of our students and our faculty members that thegraduating class did so well in the NIRMP. Special recognition should be given to the Residency PlacementCommittee and its Chairman, Dr. Richard Rothberg, fortheir time and effort expended on behalf of the seniorstudents. Moreover, the various departmental subcommittees, especially the one in Medicine, did yeoman service in counselling the students in their choice of hospitals. "1 Baltimore City H. Martin Luther King H., L.A. Stanford Univ. H.3 Barnes H. Group 1 Massachusetts General H. Strong Memorial H., N.Y.Beth Israel H., Boston 1 Mayo Graduate Sch. of Med. The New York H., N.Y.C.Boston H. for Women 2 Medical College of Va. H. 1 U. of Calif. Affil. H., IrvineBronx Municipal H. Ctr. 6 Michael Reese H. 4 U. of Calif. H., S.F.Case Western Reserve Affil. 1 Montefiore H. Ctr., N.Y. 17 U. of Chicago H.C. Kettering H. Dayton, OH. 3 Mt. Zion H., S.F. 1 U. of Colorado H.Children's Ctr.-U. of Wash. H. 4 North Carolina Memorial H. 1 U. of Hawaii Integ. Res. Prog.Cook County H. 1 Northwestern Univ. Med. Ctr. 3 U. of Iowa H.Duke Univ. Med. Ctr. 1 Overlook H., N.J. U. of Kentucky Med. Ctr.Eugene Talmage H., GA. 1 Philadelphia Naval H. U. of Maryland H.Georgetown Univ. H. 1 Presbyterian H., N.Y. U. of Michigan H.Grady Memorial H. 3 Presbyterian-51. Lukes H. U. of Missouri Med. Ctr.Hartford H., CT. 2 Presbyterian Univ. H., Pitts. U. of Oregon Med. Ctr.H. of Univ. of Pa. 3 San Diego County Univ. H. 1 U. of Texas, S.W. Affil. H.Indiana Univ. Med. Ctr. 1 San Francisco General H. 3 U. of Washington Affil. H.1 Johns Hopkins H. 2 51. Louis Children's H. 1 U. of Wisconsin H., Madison2 L.A. County Harbor Gen. H. 51. Paul Ramsey H., MN. 1 Virginia Mason H., Seattle, WA.1 L.A. County-USC Ctr. Shepard-Enoch Pratt H., MD. 2 Yale-New Haven Med. Ctr.1 Maricopa Cty. H., Phoenix24Comprehensive Medicine In IndustryDr. Peter WolkonskyDr. Peter Wolkonsky received his Ph.B. from The Universityof Chicago in 1946, his S.B. in 1950 and M.D. from TheUniversity of Chicago Pritzker School of Medicine in 1952,Alpha Omega Alpha, 1951. He did his training in medicineat Presbyterian Hospital in New York, where he was chiefresident in medicine, and then practiced at the privatepavilion and taught at Columbia College of Physicians andSurgeons. In 1961, he joined the staff of the Standard OilCompany (Indiana) as chief physician, and the first internistin the medical department. He has been director of theMedical and Environmental Health Services departmentsince 1966. Dr. Wolkonsky is Associate Professor of Clinical Medicine, and of Preventive Medicine and CommunityHealth, at Northwestern University Medical School and Adjunct Associate Professor of Environmental Health, University of Illinois School of Public Health.Aside from its bright red color, the emergency hot-line onthe 38th floor of the Standard Oil Building looks like anyother telephone. But it is not just another phone. It bringsmessages of distress to Standard's medical department.When it rings, specialists rush to the cardio-pulmonaryresuscitation cart and set the stop clock. They are readyto handle whatever problem awaits them.The clock tells them exactly how much time elapsesbetween their receipt of the emergency call and the moment they reach the patient's side. For instance, theyhave to minister to a cardiac arrest victim within fiveminutes.After that, it's likely to be too late. They can be anywhere in the 80-floor building within two and one halfminutes. When the red phone sounds, freight elevator 41(the only one in the building that goes from the top floorto the bottom) automatically cancels all other calls andproceeds directly to the 38th floor.The emergency cart is equipped with defibrillators, anEKG machine, oxygen masks, external massage, aspirator, drugs and other survival paraphernalia. It is usedfrom three to ten times a month but fortunately has notyet been required for its main intended purpose, thetreatment of cardiac emergencies.This emergency procedure is just one of many aspectsof the comprehensive Medical and EnvironmentalHealth Services program of the Standard Oil Company(Indiana), under the director of Dr. Peter Wolkonsky.While the medical department is well equipped to handleemergencies, it is geared toward preventing them."We want to help our employees to stay alive andproductive," Dr. Wolkonsky says. "We practice preventive medicine."Periodic examinations are the mainstay of the medicalprogram. A thorough medical history is taken. An internist examines the employee, who then goes through abattery of vision audiometer, x-ray, pulmonary function,blood chemistries, electrocardiograph, and other diagnostic tests. If necessary, other indicated medical testsmay also be given. "We are looking for everything fromgout to cancer," Dr. Wolkonsky says. "These examinations very often uncover problems which the patient didnot know he had, and which can be treated. The employee can then arrange to get the proper treatment forhis disorder."25Cardia-pulmonary-resuscitation cart.Periodic examinations are voluntary and confidential,and are offered according to the projected health needs ofeach age group. Those under 40 can choose to be examined every three years; those 40 to 50 every two years;and those over 50 every year."As soon as we have our staff up to full strength," Dr.Wolkonsky says, "each employee will receive a letterHearing test.26 from us when he or she is eligible for an examination.Unfortunately, we are not able to do this now because wedo not yet have enough doctors."The medical department provides treatment for occupational injuries or illnesses. Otherwise, except foremergencies, the services are primarily diagnostic. If anexamination uncovers an illness or injury, a physicianwill counsel the employee and recommend that he or shebe treated by a specialist or personal physician. If someone does not have a private physician, a departmentphysician can refer him to one. The department tries towork closely with the private physician in following and,when necessary, assisting in managing cases in whichpositive findings have been made.Since employees, along with their private physicians,are responsible for management of their personal medicalproblems, treatment in the medical department is limitedto emergency care and to short-term help for temporaryproblems. For example, a patient may be given painmedication and be put to bed in one of the two-bed wardsfor a short time. In practice, the doctors and nurses mayhandle such problems as sprained ankles or migraineheadaches, or such potentially major problems as breathing difficulties.Health care counseling is a vital part of the program.The internist or other medical personnel will explain tothe patient what the implications, risks and controls arefor his particular problem. A diabetic, for example,would be advised (in cooperation with his private physician) as to the nature of his disease and appropriate management measures, and would use the medical department for necessary follow-up such as routine tests ofblood sugars.Four full-time and two part-time internists, three registered nurses and a laboratory technician provide the medical care for the more than 5,000 employees of StandardOil Company (Indiana). In addition, they provideemergency treatment for the other tenants of the building. The medical staff sees between 700 and 800 personsa month. Dr. Wolkonsky projects that another three internists are needed to complete the staff.Medical facilities at the Standard Oil Building includeoffices, two nursing stations, ten examination rooms, anemergency room, two two-bed wards, laboratory andx-ray facilities, specialized diagnostic and treatmentrooms and an exercise room. The diagnostic and treatment rooms are equipped for physiotherapy (includingdiathermy and whirlpool treatments), cardiac stress testing, pulmonary function, audiometry, and vision testing,and endoscopic and gynecologic examinations. There is,in addition, a wide variety of medical equipment whichcan be used in emergencies. If someone breaks a legwhile on the job, he can be picked up on a special chairwhich, when transformed into a mobile bed, can beraised (to place the patient on the examination table) orlowered (to place him in an ambulance). The medicaldepartment has x-ray equipment, includingimage-intensifier, sufficient for routine films and contraststudies.Coded indicator lights in each doctor's office, in thenursing station, and in waiting areas, show which roomsare in use, which facilities are staffed for service, andwhich need extra personnel."We have a considerable amount of gadgetry," Dr.Wolkonsky says, "but the basis of our program is thesound expertise provided by the highly trained staff ofinternists and other medical and health care personnel."Other significant parts of the medical program arepre-employment and return to work examinations (forthose who have been out more than three days due tosickness). Employees and their families are also examined before they leave for overseas assignments.A cardiac stress-testing laboratory and fitness facility is open to employees in need of cardiovascular rehabilitation and to designated men in management positions."Every year, between one and three people die of heartattacks at their desks," Dr. Wolkonsky says. The cardiac stress-test laboratory is designed to help preventthese deaths. Before admittance to the program, the employee is tested on a treadmill. The amount of energyneeded to walk this mill is gradually increased in order tofind how much physical exertion the individual can endure. An individualized exercise program, administeredby a trainer working under a physician's supervision, isthen developed to help improve the employee's physicaltolerance.There are 12 exercise stations in the cardiac fitnesslaboratory. They include skip ropes, a stationary bicycle,a rowing machine, a balance beam, a speed (punching)bag, a medicine ball, a thigh-leg table, wall weights,rings, parallel bars, and weights. Optimally, each personwould spend one and a half minutes at each of the stations, with a short rest period between and repeat theprogram three times each week. Individuals use stationsthat are specified in their own exercise program. Duringrest periods, they take their own pulse to make sure thatit is higher than it would be when the body is at rest butlower than their maximum endurance capacity. The facility is designed to handle 12 persons at one time or a totalof 150 a week.The cardiac fitness laboratory is open from 8:00 a.m. to5:00 p.m., and participants are not allowed to talk business or take phone calls while in the exercise room."Since many of the executives, however, feel themselvesto be too busy during the working day to devote an hourto the program," Dr. Wolkonsky says, "our facility ismost crowded during lunch hour." Some employees prefer to use the room at the end of the day.A description of the medical department's serviceswould be incomplete without mention of theenvironmental-health services section. Director PaulHalley and most of the 17 staff members are graduateengineers, toxicologists or industrial hygienists. They areinvolved in establishing and maintaining proper standards of safety, hygiene and toxicology control at thenumerous facilities of Standard Oil Company (Indiana)and its Amoco subsidiaries."We are trying to run the medical department out ofbusiness," Halley says with a smile. But there is nocompetition between the two divisions of the medicalprogram. They are designed to work in tandem to provide top quality health care for the employees.The safety division has been operating since the 1920s.The hygiene and toxicology division were established byMr. Halley in 1953. In addition to monitoring the working conditions within the Standard Oil Building, theenvironmental-health services section monitors theworking conditions at the company's various refineries,chemical plants, oil producing areas and marketing departments both in this country and abroad ..Standard Oil of Indiana has had a medical programsince 1929. Under the direction of Dr. Wolkonsky, it hasdeveloped into one of the most comprehensive corporatemedical programs in the country.27Bi-Sci Council ExpandsThe Board of Trustees of The University of Chicago hasapproved the nomination of ten new members to theCouncil for the Biological Sciences, the visiting committee to the Division and The Pritzker School of Medicine.The appointments were announced by A. N. Pritzker,Chairman of the Council. Appointed for terms expiringSeptember 30, 1977 were:Mr. Marshall Bennett, PartnerBennett and KahnweilerDr. Robert M. Chanock (,47), ChiefLaboratory of Infectious Diseases, N.I.H.Mr. Harold H. Hines, Jr.Executive Vice President,Marsh and McLennanMr. Thomas F. Hones, Jr.Vice President, Trust DepartmentHarris Trust and Savings BankMr. Everett Kovler, PresidentJames B. Beam Distilling CompanyMr. Robert G. Myers, Senior V.P.R. R. Donnelley and Sons, CompanyMr. David D. Peterson, PresidentFansteel, Inc.Mr. Milton E. Stinson, PresidentAnswering Systems, Inc.Mr. Arnold R. Wolff, Vice PresidentInsilco CorporationNew members attended the Council meeting June 2.At that time, the Council reviewed the progress of theDivision's Diabetes Center which was dedicated lastNovember .. It is one of five federally supportedDiabetes-Endocrinology research centers in the nationand the only one in the Midwest. A noon luncheon at theNathan Bederman (left) Dr. Catherine Dobson ('32), and Dean DanielTosteson at reception.28 Dr. Donald Steiner ('56), Earl W. Shapiro, and Martin J. Koldyke.June meeting included presentations by Dr. DonaldSteiner (,56), A. N. Pritzker Professor and Chairman,Department of Biochemistry; Professor, Department ofMedicine, and the College and Director of the DiabetesCenter, and Dr. Arthur Rubenstein, Professor and Secretary, Department of Medicine, and Program Director,Diabetes Center. Afternoon sessions included facultypresentations in the Cummings Life Science Center,tours of both the clinical and basic science facilities andsmall group discussion periods. Participating were Drs.L. Frohman, Michael Reese Hospital, Ira Wool (,53), H.Tager, A. Lernmark. Project reports were presented byDrs. D. Horwitz, F. Thorp (,60), L. Slowie, nutritionist,and Ms. N. McCleary, nursing department.That evening, Dr. and Mrs. Leon Jacobson hosted areception in honor of Dr. Daniel Tosteson, newly appointed Dean of the Division. Drs. John W. Green (,46),Clayton Loosli (,37), and Catherine Dobson (Rush '32)were among the alumni present.In November, the Council will sponsor a scientificprogram and dinner honoring Dr. Jacobson who has retired as Dean of the Division of the Biological Sciencesand The Pritzker School of Medicine.SAVE THE DATESaturday, November 8The Council for the Biological Sciences will sponsor and host a Scientific Program and Dinner honoring Dr. Leon O. Jacobson.Scientific papers will be presented at the Universityin the afternoon.The "Black Tie Optional" dinner will be held atThe Hyatt Regency, Chicago.For information, write the Councilor call 947-5271.Fund-raising: A Family AffairTwenty-eight years ago, Chicago businessman MauriceGoldblatt proposed building a cancer hospital at TheUniversity of Chicago in memory of his brother NathanGoldblatt, who had died in 1944.Now 83 years old, Maurice Goldblatt is still very active raising funds for The University of Chicago Medicalcomplex. In fact, his whole family is now involved, including his wife, Bernice Goldblatt, his son anddaughter-in-law, Stanford and Ann Dudley Goldblatt,his daughter and son-in-law, Merle and Seymour Cohen,and his sister-in-law, Frances Goldblatt, Nathan'swidow. His brother Louis, President of the family business, Goldblatt Brothers, Inc., is also active in fundraising efforts among Goldblatt employees.Much of the Goldblatt family effort has been in fundraising for cancer, gastrointestinal, and heart research atThe University of Chicago. The Goldblatt family hasmade substantial contributions to the University and hashelped raise several million dollars for medical researchin the Division of the Biological Sciences and The Pritzker School of Medicine.Maurice Goldblatt, who with his brother Nathanfounded Goldblatt Brothers, Inc., in 1914, was a pioneerin urging greater U.S. private and public expenditure formedical research. A member of Surgeon GeneralLeonard Scheele's National Advisory Council in the late1940s and 1950s, he helped build public support for U.S.health programs long before the "War on Cancer" wasconceived.In 1944, Nathan Goldblatt died of stomach cancer. Hisbrother Maurice decided to retire from business and devote the rest of his life to fighting cancer.Maurice Goldblatt visited Chicago area medical centers and tried to interest them in starting a cancer research hospital. In 1946, he found President Robert M.Hutchins of The University of Chicago receptive to hisidea. Goldblatt promised $1 million for the six-storyNathan Goldblatt Memorial Hospital, which was dedicated on the University'S Hyde Park campus in 1950.In 1947, Maurice Goldblatt started The University ofChicago Cancer Research Foundation. UCCRF and acluster of affiliated societies annually raise hundreds ofthousands of dollars for cancer research at the University. Goldblatt is honorary Chairman of UCCRF and isstill very active in it.The two-story Goldblatt Pavilion, in which diagnostictests are given in-patients and out-patients, was dedicated in 1961.Bernice Goldblatt, the wife of Maurice and mother ofStanford Goldblatt and Merle Cohen, is President of theWomen's Auxiliary of the Gastrointestinal ResearchFoundation (GIRF) of Chicago. GIRF raises funds forgastrointestinal research at The University of Chicago.Its annual Bill Blass fashion show, a fund-raising event,is usually held in August.Mrs. Goldblatt was also one of three chairpersons of Bernice Goldblatt (leit), Merle Goldblatt Cohen, Stanford Goldblatt.the fourteenth Annual GIRF Ball, which was held June20 in the Continental Plaza Hotel. A testimonial dinnerfor Dr. Joseph B. Kirsner of The University of Chicagowas held in conjunction with the 1975 Ball. Dr. Kirsner,world-renowned gastroenterologist, is Honorary Chairman of GIRF. Dr. Kirsner is Chief of Staff of The University of Chicago Hospitals and Clinics and is DeputyDean for Medical Affairs and the Louis Block Distinguished Service Professor in the Department of Medicinein the Division of the Biological Sciences and The Pritzker School of Medicine.Emmett Dedmon, a University of Chicago Trusteeand Vice President and Editorial Director of the ChicagoSun Times and Chicago Daily News, was the principalspeaker at the June 20 dinner for Dr. Kirsner.Frances Goldblatt, the widow of Nathan Goldblatt, issponsor of the Nathan Goldblatt Society for Cancer Research, a UCCRF affiliate. She is also a Trustee andmember of the UCCRF Women's Board.Maurice Goldblatt makes "hospital rounds" with surgeon Rober! Replogle.29Dr. Robert Replogle (left) and Maurice Coldblatt look at portrait of NathanColdblatt displayed at the entrance of the Nathan Coldblatt MemorialHospital.Stanford Goldblatt, 36, who attended The Universityof Chicago Laboratory High School, is a Trustee of theUniversity. As such, he is heavily involved in the $280million Campaign for Chicago, the University's currentfund-raising effort.Says Stanford Goldblatt, "My assignments are in theindividual gift areas. We are now in the 'major gift' partof this campaign. My responsibility is to solicit potentialdonors for academic specialty areas of interest to them.Many of them are interested in medical matters."The principal problem in medical fund-raising, according to Goldblatt, is "getting the person to make a tour ofthe facilities. Once you have the prospective donor onthe premises and can show him what's going on, the selling job is easy because the story is an effective one."Goldblatt is on the Hospitals and Clinics Committee ofThe University of Chicago Trustees, which is responsible for the budget of the Hospitals and Clinics.He is also on the Council for the Division of theBiological Sciences and is Chairman of the Council'sSub-committee on Patient Care. He says, "The besthealth care possible is not simply having the most advanced machines or being able to provide the mostdifficult procedure. It includes services, from diagnosisto physical maintenance, food and other amenities. Toattract the patients we need-so-called tertiary referralpatients-we've got to provide a broad range of services. "Goldblatt is also on the Board and Associate Board ofThe University of Chicago Cancer Research Foundation, and has been involved in the many fund-raising efforts of UCCRF."This is an area where a great activity has been developed, and we certainly expect to continue it," hesays."I am interested in cancer, of course, but also in abroader range of activities. We're trying to organize a30 UCCRF-type organization for cardiovascular research,for example. I hope this will come to pass shortly. Also,anyone who is not interested in completing the funding ofthe new Surgery and Brain Research Pavilion is closinghis eyes to a very important problem."It is quite clear to anybody who is knowledgeablethat The University of Chicago is the premier medicalcenter in Chicago if not the Midwest, but it requires aconstant public relations effort to make it evident to theman on the street."Ann Dudley Goldblatt, his wife, is, like Stanford, alawyer by training. She is on the Steering Committee ofthe Women's Board of The University of Chicago. Recently she has been involved in fund-raising for the Regenstein Library. When the Goldblatt's three childrenare older, she may return to the law. Foreseeing thispossibility, she is becoming acquainted with the legal aspects of medicine.Merle Goldblatt Cohen-Mrs. Seymour Cohen-isStanford's sister. She is currently Chairman of theUCCRF Women's Board and has twice served as CoChairman of the annual Grand Auction. The Grand Auction is co-sponsored by the Women's Board and theUCCRF Associate Board of Trustees. Last year'sGrand Auction raised $161,000 in support of cancer research at the University. A large portion of that moneywent to the Ben May Laboratory for Cancer Research.The next Grand Auction will be held November 14 in thePick-Congress Hotel, Chicago. Mrs. Cohen says paintings, furniture, bicycles, jewelry, furs, and pets are usually offered for sale.Seymour Cohen, her husband, is a member of theUCCRF Associate Board of Trustees, a group of youngexecutives who, it is expected, will become UCCRFTrustees.Today, Maurice Goldblatt continues, as always, hisfrequent visits to The University of Chicago Hospitalsand Clinics. "It keeps me young," he says. Through hisown foundation, the Cancer Research Foundation, hemakes frequent research grants to individual medical scientists.Stanford says: "My father has retired from variousthings very many times, but his health is so good and he'sso vigorous that he doesn't stay totally retired. He's always been very eager for all of us to become involved inthe activities at the University so that there will be continuity. ""He's unbelievable," says Mrs. Cohen. "I am veryproud to be associated with the University. My fatheralways hoped that we would become involved."Employees of Goldblatt Brothers, Inc., constitute theother "members" of the Goldblatt "family." They raisemoney for cancer research each year through their ownemployees' fund-raising organization.About a dozen UCCRF auxiliaries and affiliates raisefunds through such activities as collecting money onChicago-area street comers, holding raffles and dinners,and placing paid notices on the obituary pages of Chicagonewspapers suggesting memorial donations to medicalresearch.J.5.5.Medical Alumni Day-1975Humanizing Medicine: Patient Relations"What can 1 presume to tell you aboutmedicine?" Ann Landers asked the 1975graduates and the faculty members ofThe Pritzker School of Medicine at theMedical Alumni Association's ReunionBanquet, June 12.The clinking of glass and silverware,the occasional circulation throughout thedining hall and the buzz of conversationwere suddenly suspended as nearly 500persons awaited the answer. It camequickly. Leaving the issues of malpractice, medical ethics and distribution ofmanpower to others, Miss Landersspoke instead of her area of expertise:respect for the humanity of the individual."Dear Doctor," she began, "I have aproblem. 1 receive 1,000 letters a day, atleast 200 of which should be addressed toyou. They are from people who aresuffering-from ulcers, from lower backpains, from desperation."Do tell the woman with migraineheadaches that she doesn't have a braintumor. Do tell the man whose stomach istied in knots that he doesn't have cancer.But don't tell them that there is nothingwrong with them. There is somethingterribly wrong. What you mean is thatthere is nothing physically wrong withthem. But disease means more than illness. Dis-ease. Discomfort. Distress.These people are lonely, they are frightened. The mass of men do, indeed, leadlives of quiet desperation."You are drowning in paper work.You have a tremendous patient load.You cannot listen to the woman whoneeds to talk for hours about her badmarriage. But you can listen for 10 minutes. You can steer her to a marriagecounselor or someone else who can help.You are not just menders of brokenbodies. You are menders of brokenspirits. Anyone of you that cannot saythat of yourself is in the wrong profession. "Miss Landers, who is Mrs. Jules Lederer in private life, spoke with warmth,sincerity, wit, and concern about theneed for humane medical care. Thatconcern is shown daily as Ann Landerscalls upon authorities in the medical fieldfor answers to questions from those whoread her syndicated column. It is alsodemonstrated when she gives of her timeto work for health institutions and issues. But it goes beyond this. The extentof her interest was perhaps best illus- trated when, in discussing research inBoston, she inadvertently said Washington. Quickly catching the faux pas, sheexplained, "We have some very important bills coming up in Washingtonsoon!" Miss Landers is a lobbyist without portfolio for health care legislation.The use of the collective "we" also emphasized, once again that medical care isnot simply the realm of those in the profession but also of the public that itserves.Her keynote address to the graduatescapped an evening of activities for theemerging practitioners. They stood atrapt attention moments later when theywere formally initiated into the medicalprofession. As Dr. Rory Childers intoned the final words of the Oath of Hippocrates, there was a chilling silence.For what seemed like an interminablemoment, no one spoke, no one moved.The graduates and their families savoredthe moment. One parent came from asfar as Taiwan to see her son graduate;others came from only a few blocksaway.The masks of drama and comedy werequickly interchanged throughout theevening as moments of reflection meltedinto laughter. The mood was serious, forexample, when Dr. James McClintock('42)-who established the McClintockaward for excellence in teaching in honorof his father, J. A. McClintock-warnedthe new graduates not to lose contactwith each other. "Organize now," hesaid, "and don't ever lose touch witheach other. Begin now to make donations to the outstanding institution fromwhich you have received your medicaldegree. Your degree becomes morevaluable as the school becomes stronger,which it can only do if it has the moneyto continue to grow."Laughter soon followed this solemnmoment as the graduates aimed good natured gibes at their professors. The students and their teachers roared and applauded as senior skits were presented tothe parents and faculty. There seemed tobe a good will that cut through the acid ofthe playful jabs at the "trials and tribulations of the medical students."The banquet for the graduates ended aday filled with activities for the medicalschool alumni. The day began at 8 a.m.and ended about 14 hours later. It allowed all those who shared in the celebration to have their own moment of glory. There was a breakfast for the Century Club members (honoring those whohave given $100 or more to the medicalschool); a scientific program which focused on the distinguished contributionsof six alumni; a luncheon honoring theclass of 1925; and campus tours to welcome all alumni back to the fold. On theevening of June 11, the classes of 1945,1950, and 1955 each had dinner reunionsat downtown restaurants.Throughout the day and evening ofJune 12, graduates, alumni, and facultymembers were given awards in recognition of their contributions to medicine.Mrs. Lederer was presented a gift for herinterest in medicine and in the medicalschool. Graduate Mary Patricia Paulypresented the gift on behalf of the classof '75. It consisted of a history of TheUniversity of Chicago and an illustratedvolume of the bicentennial history of theUnited States. Others to receive awardswere:GRADUATES:Graduation with HonorsRichard E. ChamplinBruce Alan EvansMary Ellen Broadstone GaekePhilip Granville HaysWilliam Ming Fu LeeJennifer Leaning LinkRichard Martin PauliRichard L. SchilskyGary SlutkinAlpha Omega AlphaB. Marc BissonnetteRichard E. ChamplinMarion DanisBruce Alan EvansMary Ellen Broadstone GaekePhilip Granville HaysLisa Glauser KaplowitzWilliam Ming Fu LeeJennifer Leaning LinkRichard Martin PauliNeil D. RudoRichard L. SchilskyGary SlutkinRalph Earl SteeleMichael Miller ToddBruce Harland WainerStephen James WalkerMark E. WheelerThe Joseph A. Capps Award, to a seniormedical student for proficiency in clinical medicine: Lisa Glauser Kaplowitz.The Franklin McLean Medical StudentResearch A ward, to a senior who hasperformed the most meritorious research: Wai-Kwan Alfred Yung.3132 231. Dr. Mary Pat Pauly ('75) presents a special award to guestspeakerAnn Landers.2. Outstanding graduates received special recognition. DeanCeithaml presents award to Dr. Richard Pauli ('75).3. Dr. James McClintock (,42)4. Dr. Leon Jacobson ('39), left, Dr. Walter Palmer ('21).455. Medical Alumni staff.6. Dr. Mary Ellen Caeke ('75) presents McClintock Award to Dr.Moon Kim.7. Dr. Otto Trippel (,46), right, reads citation to "Jake."8. Dr. Rory Childers administers Hippocratic Oath.7 6833The Medical A lumni Prizes, to seniors forthe best oral presentation of researchdone during their years in medicalschool: Felix Ki Chen and Joseph D.Locker.The John Van Prohaska Award, for outstanding potential in teaching, research, and clinical medicine: RichardMartin Pauli.The Mary Roberts Scott MemorialPrize, to a woman medical student foracademic excellence: Mary EllenBroadstone Gaeke.The Nels M. Strandjord MemorialAward, to a senior medical student foroutstanding performance in the general field of Radiology: Court BaldwinCutting.The Upjohn Award in Medicine, to asenior for outstanding achievementduring four years in medical school:Jennifer Leaning Link.FACULTYGold KeyWilliam L. Doyle, Professor, Department of Anatomy; Faculty, '42-.Presented by: Lorna P. Straus, S.M. '60,Ph.D. '62, Associate Professor, Department of Anatomy and the College,and Dean of Students in the College.Donald E. Cassels, Professor Emeritus,Department of Pediatrics; Intern, '37;Resident, '38-40; Faculty, '40-:Emeritus, '74.Presented by: Burton J. Grossman, '49,Professor, Department of Pediatricsand LaRabida-University of ChicagoInstitute. 10A special Gold Key was presented toDr. Leon Jacobson, former Dean of theMedical School by Dr. Walter Palmer('21), Richard T. Crane ProfessorEmeritus, Department of Medicine. Onbehalf of the alumni association, President Otto Trippel ('46) gave Dr. Jacobson bound volumes of Medicine on theMidway with the following citation:To "Jake,"Student - Alumnus - PhysicianTeacher-S cientist-A dministratorDean -P hila n t hrop ist -H u rna nit (I ria nand Friend to many.In appreciation and love for theloyalty, generosity, and dedication youhave given to your A Ima Mater and thusto the community of men.34 912139. Dr. Joseph Evans presents distinguished service award to Dr. John Beal ('41).10. Class of 1925: Top row: (left), Dr. Chauncey G. Burke, Dr. Norman Leshin, Dr. I. PatBronstein, Dr. Maurice P. Meyers, Dr. Henry Periman, Dr. Angus McDonald, Dr. Samuel L.Perzik, Dr. George B. Callahan. Bottom row: (left), Dr. G. Clare Bishop, Dr. Ellen Fooklen Leong,Dr. Irene T. Mead, Dr. Esther Somerfeld-Ziskind, Mrs. Mildred Stewart, Dr. Leander Riba, Dr.Allan T. Kenyon.11. Class of 1945: Dr. Chauncey Maher (leit), Dr. Eugene Mindell, Dr. Stewart Taylor.12. Class of 1950: Dr. Martin Kohn (left), Dr. Theodore Johnston, Dr. Marjorie Braude, and Dr.Louise Cason.13. Class of 1955: Dr. James Mead, (left)-husband of Dr. Sharon Mead and son of Dr. IreneMead ('25)-Dr. William F. McColl, lr., Dr. Dorothy E. Milton, Dr. Sumner Kraft, Dr. SharonMead, and Dr. Howard R. Engel. Palmer TributeYour council, has kindly invited me toaward in its behalf a special Gold Key. Iam very happy to do so. I present to youa man whom you all know and honor,but I warn you not to jump to any hastyconclusion regarding his identity. Thereare, I am sure, many men whom youknow and honor. He is a man who couldhave been, or perhaps I should say, aman who could have remained a nationally and internationally famous gastroenterologist. But fate had other plans forhim. In the words of John GreenleafWhittier:Of all sad things of tongue or pen,The saddest are these: "It mi�hthave been."He might have been simply a gastroenterologist!Instead of what might have been, Igive you a man of science. A man whoseachievements in research are universallyrecognized. I give you a man of humbleorigin, a man who, nevertheless, is athome in the seats of the great; a man whois able to convince the generous benefactors of education in this country that TheUniversity of Chicago-our beloved institution on the Midway-needs theirsupport. This man is also highly esteemed by the large charitable foundations of our country-foundations withmoney to invest in science, in humanwelfare and in enterprises thought to beinnovative. I give you a man familiarwith the intricacies of the National Institutes of Health, one who took the adviceof Alexander Pope in that he tasted anddrank deep of the Pierian Spring, theever-flowing source of research funds. Igive you a man who, to paraphraseRudyard Kipling, can walk with kingsnor lose the common touch-as is indeedrevealed by his popularity with the students and by the affectionate esteem inwhich he is held by his patients. I giveyou then, for the honor of a specialaward of the Gold Key of the MedicalAlumni Association, a physician who isa superb clinician, a teacher who standsout above his fellows, an investigatorwhose work has been applauded at homeand abroad, a man who is honored theworld over. I give you Dr. Leon Jacob-son.Walter PalmerALUMNIDistinguished Service AwardsJohn D. Arnold ('46), Director of theHarry S. Truman Research Laboratory and Professor of Medicine, Uni-35versity of Missouri School ofMedicine, Kansas City, Missouri.Presented by: Paul E. Carson, Chairman, Department of Pharmacology,and Professor, Department ofMed ici ne, R us h- Presbyterian-St.Luke's Medical Center.Alvan R. Feinstein ('52), Professor ofMedicine and Epidemiology, YaleUniversity School of Medicine, NewHaven, Connecticut.Presented by: Alvin R. Tarlov ('56),Professor and Chairman, Departmentof Medicine.Richard S. Farr ('46), Chairman, Department of Medicine, NationalJewish Hospital and Research Centerand Professor of Medicine, Universityof Colorado Medical Center, Denver,Colorado.Presented by: Peter De Bruyn, Professor, Department of Anatomy.Attallah Kappas ('50), Professor andPhysician-in-Chief, The RockefellerUniversity Hospital, New York, NewYork.Presented by: Stanley Yachnin, Professor, Department of Medicine andHead, Section of Hematology andOncology.Charles F. Barlow ('47), BronsonCrothers Professor, Department ofNeurology, Harvard UniversitySchool of Medicine, Boston, Massachusetts.Presented by: Sidney Schulman ('46),Ellen C. Manning Professor, Department of Medicine (Neurology).John M. Beal ('41), Professor andChairman, Department of Surgery,Northwestern University School ofMedicine, Chicago, Illinois.Presented by: Joseph P. Evans, Professor Emeritus, Department of Surgery(Neurosurgery); Latin AmericanLiaison Representative, The American College of Surgeons."Fifty Year" Certificates(Class of 1925)G. Clare Bishop, MichiganI. Pat Bronstein, IllinoisChauncey Burke, MichiganGeorge B. Callahan, IllinoisWalter F. Hoeppner, IllinoisAllan T. Kenyon, Illinois (Professoremeritus, Department of Medicine)Samuel A. Leader, IllinoisEllen Fooklen Leong, ConnecticutNorman Leshin, IllinoisIrene T. Mead, IllinoisMaurice P. Meyers, MichiganAngus McDonald, CaliforniaWilliam M. McMillan, Illinois36 Henry Perlman, Illinois (Professoremeritus, Department of Surgery)Samuel L. Perzik, CaliforniaLeander W. Riba, FloridaEsther Sornerfeld-Ziskind, CaliforniaREUNIONSIn addition to the 50-year reunion of theclass of 1925, members of the classes of1945, 1950, and 1955 celebrated anniversaries.The class of 1945 celebrated its 30threunion at the Tavern Club. Chairmanwas Chauncey C. Maher of Springfield,Illinois. The following attended:Bernard Block, IllinoisRalph Carlson, IndianaC. Frederick Kittle, IllinoisChauncey C. Maher, IllinoisJames McGrath, WashingtonEugene Mindell, New YorkK. Dexter Nelson, IllinoisAnthony Pizzo, IndianaPaul Strueh, IndianaStewart Taylor, WisconsinEverett Van Reken, IllinoisWarren Wilhelm, KansasThe class of 1950 held its 25th reunionin The Ninety-Fifth Restaurant of theJohn Hancock Building. Chairperson,Abbie Lukens of Hinsdale, Illinois,warmly greeted the seventeen memberswho had traveled across the UnitedStates to attend:Dean Bahler, IndianaDonald Benson, IllinoisMarjorie Braude, CaliforniaLouise Cason, FloridaPaul Fredrickson, IllinoisThomas Hill, MichiganJohn Hummel, IllinoisNewell Johnson, CaliforniaTheodore Johnston, WyomingAttallah Kappas, New YorkFrances Kelsey, MarylandMartin and Jean Kohn, CaliforniaClass of 1950 Harry Kroll, KansasAbbie Lukens, IllinoisDonald Rowley, IllinoisJay Ruzic, IllinoisSumner Kraft, chairman of the class of1955, chose the Penthouse of the Hampshire House to celebrate a 20th reunion.The committee reached 100 percent ofthe class by letter or telephone and eachmember's comments are printed in theclass newsletter. Eighteen of the class attended the reunion. Class statistics indicate all 65 class members are in a specialty and 45 (69 percent) hold academicappointments. Attending the reunionwere:Clarence E. Cawvey, IllinoisHoward R. Engel, IndianaHerbert B. Greenlee, lllinoisDale S. Grimes, IllinoisE. Jack Harris, New YorkRichard A. Katzman, OhioSumner C. Kraft, IllinoisWerner Kunz, New YorkWilliam F. McColl, Jr., CaliforniaSharon C. Mead, New YorkDorothy E. Millon, MarylandLarry Nathanson, MassachusettsRichard 1. Rubinstein, IllinoisFrederic A. Schroeder, ColoradoSaul M. Siegel, IllinoisJesse w. Tapp, ArizonaBetty Jo Tricou, IllinoisRichard C. Woellner, MinnesotaClass of '55 ... where are they now?SpecialtiesInternal Medicine 17(Gastroenterology 5)Psychiatry 15Pathology. . . . . . . . . . . . . . . . . .. 7Surgery.. ... . . . . . . .. . . . . . 5Family Medicine 4Obstetrics/Gynecology. . . . . .. 3Pediatrics. . . . . . . . . . . . . . . . . .. 3Dermatology. . . . . . . . . . . . . . .. 2Nuclear Medicine. . . . . . . . . .. 2Public Health 2ENT, Ophthalmology, Ortho-pedics, Radiology, Urology. I each65Academic AppointmentsFull time 21Part time 21Recent. .. . . . . . . . .. . . .. . . .. 345 (69%)The times changeAnd we change with them.-From Owen's EpigrammataName Graduation YearHome Address TelephoneCity, State, ZipBusiness Address TelephoneCity, State, ZipTitleNew address?New position?New medical practice?military assignment?civic or professional honor?book?Please tear out, fold, staple, or tape, and drop in the mail box. Thanks!Medical Alumni Association1025 East 57th StreetChicago, Illinois 60637 1----··-···---III PlaceII StampII HereII--------------------------------------------------Fold this flap in firstNews BriefsEvans HonoredThe Department of Biochemistry at TheUniversity of Chicago sponsored a special symposium in honor of Earl A.Evans, Jr., Professor in Biochemistryand the College and former chairman ofBiochemistry, May 23. Following theprogram, a reception and dinner for 160was held at the Quadrangle Club.Speakers included four former facultymembers at The University of Chicago:Nobel laureate Konrad E. Bloch, Higgins Professor, Harvard; Eugene P.Kennedy (Ph.D., '49), Hamilton Kuhnprofessor of biological chemistry, Harvard; Lloyd M. Kozloff (B.S., '43,Ph.D., '48), professor and chairman ofmicrobiology at the University of Colorado (faculty '49-'64); and Dr. DonaldBrown (' 56), Carnegie Institution ofWashington, department of embryology.Evans became Professor EmeritusJuly 1 and will remain at the Universityteaching in the College. He was one ofthe originators of molecular biology, thestudy of the chemical basis of life at themolecular level. He was a member of thepostwar U.S. "phage" group. Phagestudies led to the study of the structureof DNA by Sir Francis Crick and JamesWatson (B.S., '47).Evans, a native of Baltimore, studiedat Baltimore Polytechnic Institute and isa Johns Hopkins graduate. He receivedhis Ph.D. at Columbia University in1936, and joined The University ofChicago in 1937. During World War IIhe did research on malaria at the University. He served as Chairman of the Department of Biochemistry in theUniversity's Division of the BiologicalSciences and the Pritzker School ofMedicine from 1941 to 1972. He is theauthor of Biochemistry of Bacterial Viruses (1952) and edited books on respiratory enzymes and the biological action ofvitamins. In 1947-48 he served while onleave from the University as scientificattache in the U. S. Embassy, London,and in 1969 he was a fellow at All SoulsCollege, Oxford.First Horwich ScholarDr. Robert H. Kirschner has beennamed the first Ben Horwich Scholar ofMedical Sciences at The University ofChicago. Dr. Kirschner, Assistant Professor in the Department of Pathology,works on RNA tumor viruses (oncornaviruses). Genes from these virusesmay be responsible for some human cancers. In addition to biochemical analyses Eugene Kennedy (left), Konrad Bloch, Earl Evans [r., Lloyd Kozloff, and Dr. Donald Brown.Dr. Kirschner depends on electron microscopy for determining changes inDNA structure.The Ben Horwich Fund was established at the University this year by thefamily of the late Ben Horwich to support research by medical scientists atThe University of Chicago. Horwich,founder of the Precision Universal JointCompany, Chicago, died in 1961.Dr. Kirschner was Resident, ChiefResident, and Instructor in Pathology atthe University from '67 to '71. Afterserving two years with the U.S. PublicHealth Service Hospital, Baltimore, asSurgeon and Assistant Chief of Pathology, he returned to the University asAssistant Professor in the Departmentof Pathology. He held postdoctoral fellowships at the University from the U.S.Public Health Service, 1967-71, andfrom the American Cancer Society,1969-70. He won first prize from theChicago Pathological Society in 1969and in 1970 was named Resident of theYear at The University of Chicago Hospitals and Clinics.American College of Physicians Awardsand FellowsThree faculty and one former facultymember received honors at the American College of Physicians' 56th annualmeeting held in San Francisco in April.The John Phillips Memorial Award fordistinguished contributions in internalmedicine went to Dr. Leon O. Jacobson('39). The William C. MenningerMemorial A ward for distinguished contributions to the science of mental healthwent to Dr. Daniel X. Freedman. AMastership in the College was conferredon Dr. Joseph B. Kirsner. The WillardO. Thompson Memorial TravelingScholar A ward went to Dr. Richard I.Breuer (Medicine, Instructor, '65-'67) ofEvanston, Illinois. The following graduates, former housestaff and present faculty were inductedas fellows of the American College ofPhysicians, November 8, 1974 and April6, 1975:Gerald E. Bowen, Worcester, Massachussets; Edward B. Crowell, Jr.('62), Madison, Wisconsin; Ira Finegold(,63), Hollywood, Florida; Walter Fried('58), Chicago, Illinois; John D.Heywood (,59), Kirland, Washington;Adrian Katz, Chicago, Illinois; RobertW. Kellermeyer, Cleveland, Ohio; Sanford B. Krantz ('59), Nashville, Tennessee; John Laszlo, Durham, NorthCarolina; Bernard Levin, Chicago, Illinois; Monte J. Levinson, Chicago, Illinois; Marshall D. Lindheimer,Chicago, Illinois; David Lowenthal,Chicago, Illinois; Gordon L, Noel,Rockville, Maryland; Robert A. Preisman ('61), San Diego, California; RobertA. Ratshin, San Francisco, California;Jerome A. Reid, Athens, Pennsylvania;William J. Riley (,60), Houston, Texas;Lewis Sasse, Los Angeles, California;Charles A. Smolt ('28), Ventura,California; and Theodore Weinstein,Flemington, New Jersey.Ricketts AwardDr. John Allen Clements, known for hisresearch on a lung disease which is a maincause of death in newborn babies, received the 1975 Howard Taylor RickettsAward of The University of Chicago,May 22.Dr. Clements, a member of the National Academy of Sciences, is professorof pediatrics at the University ofCalifornia School of Medicine, SanFrancisco. He discussed "PulmonarySurfactant in Health and Disease."Dr. Clements has made many contributions to knowledge of the existence,composition, and biochemical action ofpulmonary surfactant, a fatty protein39formed in the lungs. By its unique surface properties, pulmonary surfactantprevents collapse of the fine air sacs ofthe lungs. Deficiency of the lung surfactant is now known to cause respiratorydistress syndrome, also known ashyaline membrane disease. Dr. Clements also found that pulmonary ischemia,a lack of blood flow in the lung, is animportant factor contributing to respiratory failure in newborn infants.Other studies by Dr. Clements led toprebirth diagnosis of fetal respiratorydistress syndrome and the successfultreatment of the syndrome by use of ahigh pressure breathing chamber.Hecht LectureNobel laureate Sir Andrew F. Huxleygave the 1975 Hans Hecht MemorialLecture, June 25. H is topic was"Theories of Muscular Contraction."Huxley is the Royal Society ResearchProfessor in physiology at UniversityCollege London. In 1963 he was cowinner of the Nobel Prize in physiologyand medicine for his researches in theelectrical activity in nerve cells. June 25,he participated in a special cardiologyseminar. His topic was "MechanicalTransients in Frog Muscle."Sir Andrew is a half-brother ofnovelist Aldous Huxley and of Sir JulianHuxley. Sir Julian, former DirectorGeneral of UNESCO, was a VisitingProfessor and received an honoraryDoctor of Science degree during theUniversity's celebration of the centennial of Darwin's Origin of Species in1959.The Hans Hecht Memorial Lecturehonors the memory of Dr. Hans Hecht,former head of the Cardiology Section('64--'71) and 'former Chairman of theDepartment of Medicine ('66-'69).Sickle Cell ExhibitDr. Theodore Cooper, Acting AssistantSecretary for Health in the Departmentof Health, Education, and Welfare, wasthe principal speaker at the dedication ofa sickle cell exhibit by The University ofChicago Comprehensive Sickle CellCenter at the Museum of Science andIndustry this March.Other speakers included Dr. RobertL. Ringler, acting director of the National Heart and Lung Institute (NHLI);Dr. Rudolph Jackson, program coordinator, National Sickle Cell DiseaseProgram, NHLI; Dr. Leon O. Jacobson, former Dean of the Division of theBiological Sciences and The PritzkerSchool of Medicine; Daniel M. MacMaster, president of the Museum of Sci-40 ence and Industry; Dr. Alex E. Boyo,professor and head of the department ofpathology (Laboratory Medicine), University of Lagos, Nigeria; and Dr. JamesE. Bowman, Director of The Universityof Chicago Comprehensive Sickle CellCenter.Dr. Bowman, who coordinated plansfor what is believed to be the world'sonly permanent sickle cell exhibit, isProfessor in the Departments of Pathology and Medicine and in the Committeeon Genetics. He is also Medical Director of the Blood Bank and Director ofLaboratories in The University ofChicago Hospitals and Clinics.The exhibit was supported by an NIHgrant to the University. It includes:-A six-foot revolving model of thealpha and beta chains of the hemoglobinmolecule with lighted sites of over 130abnormal hemoglobins, including sicklehemoglobin.-A five-minute animated color-soundfilm depicting the mechanism of sicklecell anemia.-A map showing geographic distribution of abnormal hemoglobins S, C, 0(Punjab) and E and of beta-thalassemiain human populations.-A description with selected photographs of the clinical features of sicklecell anemia.-A three-generation family tree depicting the inheritance of sickle hemoglobin.-A demonstration of the inheritanceof various combinations of hemoglobinsA (normal hemoglobin), S (sickle hemoglobin), and C by pairs of electronicallyactivated roulette wheels.-A demonstration of the laboratorydiagnosis of patterns of hemoglobins A,S, 0, C, E, and of beta thalassemia onelectrophoresis.-Photos of investigators who madethe most significant contributions to thebiochemistry and genetics of sicklehemoglobin.The exhibit was organized under a1973 grant from the Sickle Cell DiseaseBranch of the National Heart and LungInstitute to The University of Chicago forThe University of Chicago Comprehensive Sickle Cell Center. The NHLIgrant to the University provides for clinical and basic research on sickle hemoglobin at the University and at MichaelReese Hospital and Medical Center andfor a program of community education.The exhibit was planned by facultymembers who are a part of The University of Chicago Comprehensive SickleCell Center with the advice of the staffmembers of the community component,the Mid-Southside Health Planning Organization; the Director and Exhibits Manager of the Museum of Science andIndustry; and of staff members of theSickle' Cell Disease Branch, NHLI.University faculty members on thecommittee that formulated the exhibitwere: Dr. Bowman; Edward D. Garber,Professor in the Department of Biologyand the Committee on Genetics and inthe College; Eugene Goldwasser, Professor in the Department of Biochemistry, the Franklin McLean Memorial Research Institute, the Committee on Developmental Biology, and the College;Mrs. Florence Goldwasser, Administrative Assistant, The University ofChicago Comprehensive Sickle CellCenter; Dr. John D. Madden, AssociateProfessor, Secretary, and Director ofClinical Services in the Department ofPediatrics and Pediatrician in Charge ofthe University's Chicago Lying-in Hospital Nurseries; Dr. Paul Sigler, Professor in the Department of Biophysics andTheoretical Biology and in the College;and Martin Zwick, Assistant Professorin the Department of Biophysics andTheoretical Biology.Retired-But Not QuiteMichael Roma, who came to work atThe University of Chicago Billings Hospital in 1928 (the year it opened), is stillcoming in once a week to assist Dr. William B. Gill, Associate Professor andHead of Urological Surgery, in hisstudies of the crystalline nature of kidney stones.Roma recently retired as senior research technician in the Department ofSurgery after 47 years with the University. He was with the Department ofMedicine for 20 years before he joinedthe Department of Surgery in 1949. Heassisted Dr. Dallas B. Phemister, LillianEichelberger, and Dr. C. HowardHatcher in orthopedic research. Subsequently he was associated with Dr. William E. Adams, Dr. Peter V. Moulder,Dr. C. Frederick Kittle and E. F. Andrews in thoracic surgery research.Model Brain TumorUniversity of Chicago neurologists haveproduced a new type of virus-inducedexperimental brain tumor in rats. It hasbeen described as one of the best animalmodels to date for glioblastoma, themost common and highly fatal humanbrain tumor.The experimental tumors are inducedin 100 percent of the rats by the Kirstenmurine sarcoma virus (Ki-MSV). Thevirus was discovered by Dr. Kirsten.Drs. Wai-Kwan Yung (,75), NicholasA. Vick (,65), former Associate Professor in the Department of Neurology, andNathan K. Blank, Resident in neurology,found that the virus injected directly intothe brains of rats induced tumors in 100percent of the animals.Like the human brain tumors, the rattumors are large, invasive, and hemorrhagic. The model gives scientists a newway to study human brain tumors.Their research was supported bygrants from the National Cancer Institute and the National Institute ofNeurological Diseases and Stroke. Theproject is an example of work being doneon cancer at The University of Chicago,which has been designated a NationalCancer Research Center by the U. S.government under the National CancerAct of 1971.Outpatient Burn TreatmentUniversity of Chicago surgeons havedeveloped a new outpatient system forthe treatment of second-degree bums atThe Silvain and Arma Wyler Children'sHospital. The treatment involves dressing second-degree burns with a verythin, split-thickness skin graft taken frompigs. "Using this 'foreign' skin in thetreatment of bums has in the past beendone mainly with hospitalized patients,"says Dr. Melvin D. Smith."At Wyler, virtually all victims ofsecond-degree burns are now beingtreated in this manner as outpatients,with very gratifying result. Use of thisporcine heterograph burn treatmentavoids the necessity of changing dressings frequently, is very comfortable forthe patients, and aids in healing of theburned area."Dr. Smith, Visiting Assistant Professor in the Department of Surgery, is aiding Dr. John Burrington, Professor andHead of the Section of PediatricSurgery, in use of the new method.The many advantages of this technique of bum care have been reported onhospitalized patients at the State University of New York; the U.S. Army Institute of Surgical Research, Fort SamHouston, Texas; Southwestern MedicalSchool, Dallas; and Maricopa CountyGeneral Hospital, Phoenix.Dr. Burrington says: "This form oftreatment has many advantages. The patients are immediately more comfortableafter the burned area is covered withporcine skin. They also move more andtherefore have less problem with stiffjoints. We have had much less troublewith infections since beginning this formof therapy so that cost and risk to thepatient are greatly reduced."In addition to being a faculty member Dr. David Horwitzat The University of Chicago, Dr. Smithis a U.S. Air Force Medical Corpslieutenant colonel on active duty andcommanding officer (liaison officer) of allAir Force personnel attending non-AirForce schools in the Chicago area.New Diabetes TestUniversity of Chicago scientists havedeveloped a new urine test that measuresinsulin output in diabetics. It supplements an earlier blood test developed atThe University of Chicago for insulinoutput. The earlier blood test was described by the American Diabetes Association in 1973 as a "breakthrough ofthe first magnitude" in the study andtreatment of diabetes.The urine test has some marked advantages over the blood test, accordingto Dr. David L. Horwitz, who describedit in a report to the American Federationfor Clinical Research in Atlantic Citythis May.Both tests are for C-peptide, a byproduct of the production of insulin.Knowing whether there is residual insulin output in a diabetic is important indetermining the type of diabetes the patient has and may be useful in prescribing proper doses of insulin. "This information may also be useful in eventuallydeciding which patients may benefit fromnew treatment methods now being developed such as pancreatic transplantation or the artificial pancreas," says Dr.Horwitz, assistant professor in the Department of Medicine.Co-authors of the report by Dr. Horwitz were Angelita Cruz, technician inthe Department of Medicine; Dr. Adrian I. Katz, Associate Professor and Headof the Section of Nephrology in the Department of Medicine; and Dr. ArthurH. Rubenstein, Professor and AssociateChairman, Medicine, and Associate Director of The University of ChicagoDiabetes-Endocrinology ResearchCenter. Part of the research was alsodone in the University's General Clinical Research Center and in the Sectionof Endocrinology, Department ofMedicine. Both are directed by Dr.Richard L. Landau, Professor in theDepartment of Medicine and the College. It was supported by grants from theLouis Block Fund, the National Institutes of Health, the American DiabetesAssociation, and the U.S. Public HealthService.Anorexia NervosaAndy Jones, who collected three varsityletters in high school, will start collegethis fall on a football scholarship. Nowsix foot two, 195 pounds, a husky,healthy athlete, Andy was a 125-lb.weakling only two years ago. "He wasbarely able to stand," says surgeon JohnBurrington.Andy was a high school wrestler in hissophomore year. The trouble began inhis junior year, when his coach told himto keep his weight at 127 pounds, atwhich he had wrestled the year before.Andy did keep his weight down-although that year he grew five and ahalf inches. At his coach's bidding, hesubjected himself to near-starvation thatleft him literally unable to eat or drink. Apinched duodenum, the portion of thesmall intestine that receives food fromthe stomach, prevented food from passing into Andy's intestines. He was unable to keep anything on his stomach andin danger of starving.It is fairly common for young people,particularly girls, to try to keep theirweight down. In extreme cases they mayeven come close to starving themselves.The condition is usually identified as anervous disorder, anorexia n ervo sa .Some young people such as Andy may infact be wrongly regarded as having apsychosis, Dr. Burrington says. Theymay be put in a psychiatric ward andforce fed with a tube down the throat.Dr. Burrington says the physical basis ofAndy's condition is often not recognizedby physicians. It is not described inradiological literature, he says, andpsychiatrists are not familiar with itspossible physical basis, as was the casewith Andy.In holding down his weight when heshould have been rapidly growingheavier to match his new height, Andydepleted an internal layer of retro-41peritoneal fat that protected his intestinefrom being pinched. As a usual thing,this would not completely interfere withintestinal function in even extreme dieters. In some anatomically unusual people such as Andy, however, it can bedisastrous. The duodenum is located insuch a way that it easily becomespinched between the spine and a largeblood vessel, the superior mesenteric artery. Most victims of this physical condition can be brought back to health bygetting them to lie on their left sides aftereating to facilitate food passage into theintestine. But some, such as Andy, require surgery to reposition theduodenum. Andy is not unique. He isone of four male high school athleteswith "superior mesenteric artery syndrome" and one adult track competitorwhom Dr. Burrington has treated. Dr.Burrington also treated 10 such cases ofyoung girls with anorexia nervos a orwith extreme weight loss due to illness.Most of the 10 cases required surgery.He recently described the condition inthe Journal of Pediatric Surgery(October 1974).Yesterday's TeenagersDon't expect a revolution when today'syouth grow up and take over the country. The results of a recent study indicatethat the next generation is pretty muchthe same as this one. The study wasconducted by a team of researchers whointerviewed and tested 61 teenagersthrough their high school and collegeyears. The results were published thisJune by Basic Books, Inc., under thetitle, From Teenage to Young M anhood .The authors are Dr. Daniel and JudithBaskin Offer. Dr. Offer (,57) is cochairman and professor of the department of psychiatry at Michael ReeseHospital and Medical Center, is Professor of Psychiatry at the University and iseditor-in-chief of the Journal of Youthand Adolescence.Their book deals with the generationwhich lived its adolescence in the turbulent 1960' s, a decade characterized byupheaval in every aspect of Americansociety. The subjects of the Offers'study were freshmen in two suburbanChicago schools when the study began in1962. Their research spanned all of theboys' high school years, as well as thenext four. Almost all of them went tocollege, but not all spent four consecutive years on a campus. Some droppedout and re-entered at a later date.The Offers feel that their most important finding destroys the myth that allteenagers are alike and go through thesame phases at the same speeds. Theyfound that there are three general rates at42 which adolescents mature. Some growcontinuously and smoothly during theadolescent years: some grow in surges;and others grow in turmoil and createother behavioral problems. A seconddiscovery has to do with the sexual experiences of teenage boys. The Offersfound that they talk more openly and doless than adults believe. Only 10 percentof the boys had had sexual intercourseby the time they were juniors in highschool; half had lost their virginity by thethird year after their high school graduation. This is close to what Dr. Kinseyreported 20 years ago.Another bubble the Offers burst is thatteens stick together no matter what.While it is quite normal for teens to sticktogether in everyday activities, they turnto parents in times of crisis. Only thoseteens with problems at home will staywith their friends when a crisis breaks,the Offers found."The years of adolescence form atransitional period for which the rites ofpassage ought not to be too narrowlydefined. Our data lead us to hypothesizethat adolescence, as a stage of life, is nota uniquely stressful period," they write."Adolescence in our culture is a time ofphysical, psychological, social, and intellectual change, not all of which occurconcomitantly. "Their main finding, they claim, is thatteens are more like their parents thanone another.Health HazardDr. Burrington described five cases ofchildren whose esophagi had to be surgically shortened because of stricturescaused by swallowed Clinitest (R) tablets. The tablets, which are routinelyused by diabetics in tests for sugar, contain sodium hydroxide (lye). His reportwas made to the Society of ThoracicSurgeons meeting in Montreal at the beginning of the year.In each case, he said, the child'sesophagus was so badly burned andscarred that it was virtually occluded.Following surgery, periodic mechanicalenlargement (dilation) was required tokeep the remaining portions of theesophagus open. The five children werebetween 17 and 26 months old.Diabetics who use the pills for urinetests are often not aware of the danger ofthe pills when swallowed, Dr. Burrington says. "Prevention of accidental ingestion by use of a childproof containerand parental education about the causticnature of Clinitest (R) are essential ineliminating this child health hazard."The preferred antidote is cold milk ortap water, he says, disagreeing with thelemon juice and vinegar antidotes listed on the bottle. He cited a recent study, ofwhich he was co-author, that demonstrated that neutralization of the lye withacid antidotes suggested on the bottleintensifies the release of heat and probably increases the intensity of the burn.Dr. Burrington is Professor and Headof the Section of Pediatric Surgery.Esophageal SpeechThe ability of "lost chord" throat cancerpatients (laryngectomees) to learn"belched speech" may depend on a crucial muscle in their throats, says a University of Chicago gastroenterologist.Esophageal (belched) speech depends onthe ability to "swallow" air through thecricopharyngeal sphincter, according toDr. Charles S. Winans, Associate Professor in the Department of Medicine.This is the muscle that normally prevents the entry of unwanted air into theesophagus. It is believed that the soundsproduced in belched speech originate inthe esophagus. In 20 post-operativelaryngeal cancer patients, Dr. Winansfound that pressure was normally lowerin this muscle among laryngectomeeswith fluent esophageal speech.In those unable to develop esophagealspeech after laryngectomy, pressure inthis muscle was two to three times asgreat.The study was supported in part by agrant from the National Institutes ofHealth.Motivation, personality, age, intellectual capacity, and the amount and skill ofinstruction may also be important factorsin learning esophageal speech, says Dr.Winans. But a major factor is the physical ability to swallow air.Dr. Winans, a specialist in muscularaction and internal pressures in theesophagus, examined patients referredby speech therapists. Others were members of an esophageal voice club whosenewsletter described the project and solicited volunteers.Aiding Dr. Winans in the researchwere Dr. Elliot J. Reichbach, formergastroenterology resident at The University of Chicago, and William F. Waldrop of the speech and hearing clinic,Rush-Presbyterian-St. Luke's MedicalCenter, Chicago.CO InhalationYou can die of carbon monoxide (CO)inhalation if your dwelling burns-evenif you don't go near the flames. For thisreason, it is advisable to treat bum andsmoke victims in disastrous fires immediately with oxygen therapy, say ateam of University of Chicago investigators. This should be done at the siteof the fire, if possible.Chicago's two leading blood organizations, the Cooperative Blood Replacement Plan, and the Metropolitan Chicago Blood Council, merged into the Chicago Regional Blood Program March 18. Thenew officers of the organization are (from left) John J. Gerwig, executive director; Dr. Frank E. Trobaugh[t ., chairman; Dr. James E. Bowman, vice chairman (University of Chicago); S. James Schroeder,treasurer; and William M. Walsh, president. Not pictured is Howard F. Cook, secretary.The group found 8 to 40 percent concentrations of carbon monoxide-boundhemoglobin in the blood of 13 patientsexamined in The University of ChicagoHospitals and Clinics 15 to 70 minutesafter exposure to fire or smoke. Fiftypercent may be fatal, says Dr. ChristenC. Rattenborg, one of the investigators.One problem in diagnosing CO poisoning is that its victims do not tum blue likea patient with hypoxia, says Dr. Rattenborg. "Normally a patient with that degree of oxygen lack would havecyanosis, blue-colored skin or mucousmembrane. But that is lacking in thesepatients because carbon monoxidehemoglobin is cherry colored." Dr. Ratten borg is Professor in the Departmentof Anesthesiology in the University'sPritzker School of Medicine.Authors of the report are Drs. HarveyA. Zarem, Rattenborg, and Merel H.Harmel. Dr. Zarem, formerly Professorin the Department of Surgery, is now inthe division of plastic surgery at theUCLA Medical Center, Los Angeles.Dr. Harmel, former Chairman of theUniversity's Department of Anesthesiology, is now chairman of anesthesiology at Duke University.In MemoriamALUMNI DEATHS'oi. Noble W. Jones, Portland,'Oregon, February 7, 1975, age 99. '01. Duncan D. Monroe, Sterling, Colorado, February 6, 1975, age 101.'01. Leo E. Schneider, Milwaukee,Wisconsin, May 7, 1971, age 93.'04. Jonathan E. Bruner, San Diego,California, August 30, 1974, age 94.'04. Otis H. Epley, New Richmond,Wisconsin, November 5, 1974, age 94.'10. Earle B. Fowler, River Forest, Illinois, March 23, 1975, age 90., 12. Harry G. Knapp, Rifle, Colorado,December 12, 1974, age 89.'14. Gerard N. Krost, West Salem,Wisconsin, June 6, 1975, age 86., 15. Lewis A. Hopkins, Santa Barbara,California, February 1, 1975, age 91., 15. James S. Orr, Fruita, Colorado,March 24, 1975, age 85.'18. Ethel M. Davis, Chicago, Illinois,February 15, 1975, age 79., 19. Sidney R. Kaliski, San Antonio,Texas, July 20, 1974, age 74.'19. Lee H. Kiel, Green Valley,Arizona, February 7, 1975, age 83.'19. Borris J. Sherman, Los Angeles,California, May 9, 1974, age 81.'20. Jay M. Milligan, Pompano Beach,Florida, October 31, 1974, age 82.'21. Clarence N. Hatleberg, ChippewaFalls, Wisconsin, June 26, 1974, age 79.'22. Temple Burling, Trumansburg,New York, January 1975, age 79.'24. Ernest R. Anderson, Minneapolis,Minnesota, January 13, 1975, age 76.'24. Tyrrell G. McDougall, Tigard,Oregon, February 24, 1975, age 79.'26. Erling N. Larsen, Du Bois, Pennsylvania, December 15, 1974, age 75.'26. Henry Luidens, Columbus, Ohio,February 10, 1975, age 76.'28. Thomas P. Findley, Jr., Knox- ville, Tennessee, October 18, 1974, age73.'29. Willard S. Holmes, Saskatoon,Saskatchewan, Canada, November 7,1974, age unknown.'30. Leo A. Elkourie, Birmingham,Alabama, May 13, 1974, age 69.'31. Mary S. Sheppard, OklahomaCity, Oklahoma, November 8,1974, age82.'32. Robert E. Baer, Charleston, WestVirginia, June 23, 1974, age 71.'32. J. Paul Fitzgibbon, Long Beach,California, March 12, 1975, age n.'33. Robert C. Byrne, Hatfield, Massachusetts, December 4, 1974, age 67.'33. Benjamin F. Morton, Birmingham, Alabama, January 17, 1975,age 71.'34. Chester B. Thrift, Oak Park, Illinois, January 18, 1975, age 68.'35. Johnson Underwood, Jr., KansasCity, Missouri, July 12, 1974, age 66.'37. Otto E. Strohmeier, Evanston, Illinois, May 8, 1975, age 78.'38. Melvin C. Higgins, Harvey, Illinois, July 5, 1974, age 62.'39. Gilbert S. Hardie, San Diego,California, October 6, 1974, age 61.'42. Robert P. Hall, Olympia,Washington, September 16, 1974, age 65.'42. Milton A. Newman, Logansport,Indiana, April 28, 1975, age 59.'46. Paul V. Gustafson, Grandview,Washington, April 23, 1975, age 61.'63. John A. Dawley, Alton, Illinois,October 2, 1974, age 35.'63. Dick V. DeYoung, Chicago, Illinois, February 1, 1975, age 39.'72. Melvin H. Cole, New Haven,Connecticut, April 13, 1975, age 28.FORMER STAFF AND FACULTYJames D. Bisgard (Surgery, Resident,'31-'32), Carmel, California, April 24,1975, age 77.Selma Bolstad (Obstetrics andGynecology, Intern, '33), Cleveland,Ohio, December 23, 1974, age 74.Carl P. Huber (Obstetrics andGynecology, Instructor, '36-'38), Indianapolis, Indiana, July 10, 1974, age71.Melvin H. Knisley (Anatomy, faculty,'37-'48), Charleston, South Carolina,March 30, 1975, age 70.Donald A. R. Morrison (Psychiatry,Resident, '37-'38), Santa Barbara,California, July 28, 1973, age 68.Francis E. Stout (Obstetrics andGynecology, Intern, Resident, '48-'49),Muncie, Indiana, December 20, 1974,age 54.James M. Thomson (Obstetrics andGynecology, Intern, '42), Columbia,Missouri, December 8, 1973.43Departmental NewsAnatomyGrants:James A. Hopson, Associate Professor in Anatomy, the Committee onEvolutionary Biology, and the College,was awarded a $52,900 grant from theNational Science Foundation entitled"Adaptive Radiation of AdvancedCynodont Mammal- Like Reptiles," effective December I, I 974-May 31,1977.Leonard B. Radinsky, Associate Professor in Anatomy, the Committee onEvolutionary Biology, and the College,was awarded a $50,000 grant from theNational Science Foundation entitled"Mammalian Brain Evolution," effective September 1, 1974-February 28,1977.Dr. Ronald Singer, Robert R. BensleyProfessor in Biology and Medical Sciences and Chairman of the Departmentof Anatomy, was awarded a one-year extension from the National ScienceFoundation entitled "Excavation atHoxne ," in the amount of $16,000.Stuart Altmann, Professor inAnatomy, was invited to membership inSigma Xi.Winston A. Anderson, Associate Professor in Anatomy, the Committee onEvolutionary Biology, and the College,received the first Basic Sciences Teaching Award in the Medical School. Theaward was established this year bymembers of the freshman and sophomore classes. It honors a facultymember teaching basic sciences who hasshown dedication and excellence inteaching. It is voted upon by eachsophomore class. The students contributed their own money to present the $100prize. The presentation was made June3. Anderson has been a member of thefaculty since 1971. He is leaving the faculty to become chairman of the department of zoology at Howard University.Robert P. Becker, Research Associate, was appointed to the board ofadvisors for the workshop on biomedicalapplications of the scanning electronmicroscope symposium in Toronto,Canada, April 5-9, 1976. He and Paul S.D. Lin, Research Associate in the Enrico Fermi Institute, presented a paperon "Detection of Backscattered Electrons with High Resolution," at theeighth annual scanning electron microscope symposium, lIT Research Institute, in St. Louis, April 7-11. Beckerwas also a session chairman for" Biological Techniques-Cells" at that symposium.44 Winston AndersonMartin Friedlander, a graduate student, presented a lecture entitled" AnAnalysis of Cell Surface Components inDeveloping Embryonic Muscle" to thedepartment of biology, Bowdoin College, Maine, February 13.Eileen S. Kane, Assistant Professorhas been awarded a five-year USPHSResearch Career Development A wardentitled "Central Auditory System Connections in Mammals." She was also invited to membership in Sigma Xi.Dr. Charles E. Oxnard, Professor inAnatomy, Anesthesiology, the Committee on Evolutionary Biology, and theCollege, presented the following lecturesin March: "Uniqueness and Diversity inHuman Evolution: MorphometricStudies of Australopithecines" at theUniversity of Kansas at Lawrence;"Human Evolution: New Views of OldBones" at the Kansas AnthropologySociety; "Multivariate Statistics in aReassessment of the Australopithecine"at the Department of Geology, University of Rochester; and "Biological Formand Pattern: Its Study by Laser DataAnalysis" at the Department ofAnatomy, University of Hong Kong.Dr. Anthony J. Steffek, Research Associate in Anatomy, Assistant Professorin the Zoller Dental Clinic, and directorof the American Dental Association Research Institute's Division of Developmental Biology, has been elected secretary to the executive council of theAmerican Association for Accreditationof Laboratory Animal Care. Dr. A. Carl Verrusio, Research Associate in Anatomy and Assistant Professor in the Zoller Dental Clinic, presented a paper entitled" A CytoplasmicFactor Affecting Cleft Palate in Mice,"at the International Association for Dental Research in London, April 10.The following each presented a paperat the American Association ofAnatomists 88th session in Los Angeles,March 23-27: Robert P. Becker, Andrew G. Farr, Dr. Donald A. Fischman,Eileen S. Kane, Beatrice Garber, Dr.Kunihiko Kimura, R. Eric Lombard,Francis J. Manasek, Mrs. B. J. Manaster, and Philip S. Ulinski.At the 44th annual meeting of theAmerican Association of Physical Anthropologists, Denver, Colorado, April9-12, the following faculty and studentspresented papers: L. Radinsky, Dr. R.Singer, Dr. C. Oxnard, S. Altmann, G.H. Albrecht, Dr. K. Kimura, and Mrs.B. J. Manaster. Dr. C. Oxnard waschairman of the session on primate dentition and L. Radinsky was the discussantfor a special lecture on brain evolution.AnesthesiologyAppointments:Dr. Jui-Kuang Lin-Instructor.Dr. Enrique F. Via Reque-Instructor/Trainee.Promotions:Dr. Erica W. Ford-Assistant ProfessorlTrainee.Dr. Chung-Yuan Lin-Associate Professor.Ben May laboratoryElwood V. Jensen, Director of the BenMay Laboratory for Cancer Researchand Professor in Biophysics andTheoretical Biology, was one of sixfaculty members elected to the AmericanAcademy of Arts and Sciences. May 9,Jensen was awarded the $1,000 ClowesPrize of the American Association forCancer Research. He delivered theClowes Memorial Lecture at theassociation's 66th annual meeting in SanDiego on "Hormone Dependency ofMalignant Tissues."H. G. Williams-Ashman, MauriceGoldblatt Professor in the Ben MayLaboratory and in Biochemistry andPharmacological and Physiological Sciences, gave the Pfizer Foundation Lecture at the Faculty of Medicine of theUniversity of Ottawa, June 7. His lecture was entitled "Formation and Functions of Polyamines." He lectured on"Specific Basic Proteins Involved inMammalian Spermatogenesis" at theMassachusetts Institute of Technology,March 18 and at Roswell Park MemorialInstitute, Buffalo, New York, May 13.BiochemistryDr. Donald F. Steiner (,56), the A. N.Pritzker Professor and Chairman of theDepartment of Biochemistry, Professorin Medicine and in the College and Director of The University of ChicagoDiabetes- Endocrinology ResearchCenter, was among five members of TheUniversity of Chicago faculty elected tothe National Academy of Sciences,April 22 in Washington, D.C.BiologyAppointments:A. Ross Kiester-Assistant Professor.Michael John Wade, '75-AssistantProfessor.Grants:William K. Baker, Professor in Biology,the College, and the Committees onGenetics and Evolutionary Biology, isthe principal investigator for a 12-month,$44,381 grant by the National Institutesof Health (NIH) for a study on "GeneticControl of Differential Sex Function."Stuart Altmann, Professor in Biology,Anatomy, the Committee on Evolutionary Biology, and in the College, delivered a paper on the evolution ofpolygyny at the annual meeting of Animal Behavior Society in Wilmington,North Carolina.Richard Levins, Professor in Biology,Biophysics and Theoretical Biology,Genetics, and the Committee on Conceptual Foundations of Science, andLeigh Van Valen, Associate Professorin Biology, the College, and the Committees on Evolutionary Biology, Geneticsand the Conceptual Foundations of Science, were speakers at the University ofRochester's series of symposia on recentdevelopments in population biology.Dr. A. A. Moscona, Louis Block Professor in Biology, Pathology, andChairman of the Committee on Developmental Biology, was an invitedspeaker to the following meetings: TheSquaw Valley Conference on Developmental Biology, March 9-14, on thetheme "Pattern Formation and GeneRegulation in Development"; the International Scientific Committee of the Institut de la Vie which met at the WoodsHole Marine Biological Laboratory fromApril 1-4, on the subject "Tests ofTeratogenicity in Vitro"; the conferenceon "Information Transfer betweenCells" held in Titisee, Germany, April23-26; and at the European MolecularBiology Organization workshop on"Membrane Dynamics and Cell Regulation" held in Eliat, Israel, April 3D-May3.Charles E. Olmsted, ProfessorEmeritus, has been selected for a Fulbright-Hays award by the Board ofForeign Scholarships and the Department of State to lecture in Australia inthe field of environmental ecology.Biophysics and Theoretical BiologyGrants:Robert Haselkorn, Fanny L. PritzkerProfessor and Chairman of the Department of Biophysics and TheoreticalBiology, has received a grant of $93,506from USPHS National Institute of General Medical Sciences, for the project entitled: Differentiation in Nitrogen-FixingBlue-Green Algae.Marvin Makinen, Assistant Professorwas awarded an Established Investigatorship for five years from theAmerican Heart Association.Lucia B. Rothman-Denes, AssistantProfessor has received a grant of$135,926 from USPHS, National Institute of Arthritis and Infectious Diseases,for a project entitled: Novel Transcribing Activities in N4-Infected E. coli. Dr.Rothman- Denes is also the recipient of aResearch Career Development A wardfrom the National Institutes of Health.Montgomery Slatkin, Assistant Professor in Biophysics and TheoreticalBiology and in the College, was awardeda Research Career Development A wardfrom the National Institutes of Health.Elmar Zeitler, Professor in Biophysicsand Theoretical Biology, Physics, theEnrico Fermi Institute, and the College,has received a grant of$418,265 from theUSPHS, National Institute of GeneralMedical Sciences, for a project entitled:1 MEV Scanning Transmission ElectronMicroscope.Emergency MedicineDr. Marshall Segal, Associate Professor, spoke on the subject of rape on theWLS radio show, Women '75. The showwas aired Sunday, March 16 and Monday, March 17.La RabidaPromotion:Dr. Eugene N. Fox-Professor.MedicinePromotions:Dr. Joseph M. Baron (,62)-AssQciateProfessor.Dr. William A. Causey-AssistantProfessor.Dr. Louis Cohen (53)-Professor.Dr. David L. Horwitz-AssistantProfessor.Dr. Thomas M. Jones-AssistantProfessor.Dr. Adrian Katz-Professor.Dr. Elliott D. Kieff-Associate Professor. Dr. Thomas J. Layden-AssistantProfessor.Dr. Dennis J. Levinson-AssistantProfessor.Dr. Edgar M. Moran-Associate Professor.Dr. Suzanne Oparil-Associate Professor.Dr. Irwin Rosenberg-Professor.Grant:Dr. David L. Horwitz, Assistant Professor, was awarded a one-year renewalgrant of a Research and DevelopmentA ward from the American Diabetes Association.Dr. G. Jeelani Dhar, Fellow in Gastroenterology, was awarded first prize of$150 and a plaque by the Chicago Society of Gastroenterology for a paper hepresented at the meeting, April 9: "Intravenous Hematin: A Promising Modelof Therapy in Acute Porphyric Relapse. "Dr. Robert M. Bennett, AssistantProfessor, was chairman of a symposiumon systemic lupus erythematosus (SLE)at the 1975 Midwest Clinical Conferencein Chicago, April 3. He spoke on "Management of SLE."Dr. James L. Boyer, Associate Professor in Medicine and Director of theLiver Study Unit, was elected a memberof the International Association for theStudy of the Liver. He participated on apanel on chronic active hepatitis at theannual meeting of the American Collegeof Physicians in San Francisco, April 9.Dr. Richard L. Byyny, Assistant Professor in Medicine and Director of Medical House Staff Education, is author ofCase Discussions and Problems S olving, published by the Illinois Council onContinuing Medical Education,Chicago. Leonard S. Stein, ExecutiveDirector of the Council, is co-author.The new publication explains uses ofcase discussion for in-hospital continuing medical education. It includes foursample cases that have been tested foreffectiveness.Dr. Thomas F. Deuel, Assistant Professor (Hematology-Oncology), received a Faculty Research Award fromthe American Cancer Society. He isstudying the biochemistry of the enzymes of normal and cancerous cells andtissues.Dr. Joseph B. Kirsner, the LouisBlock Distinguished Service Professorin Medicine, Chief of Clinical Staff, andDeputy Dean for Medical Affairs, wasawarded the Friedenwald Medal by theAmerican Gastroenterological Association in recognition of his scientific. clinical. and educational contributions to gastroenterology in the United States. The45presentation was made at theassociation's convention in San Antonio, Texas, May 19. Dr. Kirsner washonored June 20 at the 14th annualGIRF (Gastro-Intestinal ResearchFoundation) ball in the ContinentalPlaza Hotel, Chicago.Dr. Sumner C. Kraft ('55), Professor,served as a guest faculty member for apostgraduate course on "Gastroenterology for Practicing Physicians" atMeharry Medical College in Nashville,April 24-26.Dr. Richard Langendorf, Clinical Professor, and Dr. Alfred Pick, Professor,(University of Chicago and of MichaelReese Hospital Medical Center) arejoint recipients of the 1975 GiftedTeacher Award of the American Collegeof Cardiology. It was presented at theannual fall meeting in Houston.Dr. Murray Rabinowitz, Louis BlockProfessor in Medicine, Biochemistry,and the Franklin McLean Memorial Research Institute (FMI), was an invitedspeaker at the International Symposiumon Cardiac Metabolism in Dallas,Texas, May 18-21. He discussed "Control of Protein Balance in HypertrophiedCardiac Muscle."Dr. Julian Rimpila ('66), Fellow inGastroenterology, has been cited by theChicago Society of Internal Medicineand the American College of Physiciansfor his research on "ImmuneMechanism in Inflammatory Bowel Disease." He presented the paper April 28before the two organizations. He received a prize of $150. This is the firsttime a Fellow in Gastroenterology hasreceived this citation.Dr. Arthur Rubenstein, Professor, received an Established InvestigatorAward from the American Diabetes Association at the association's meeting inNew York, June 15.Dr. John Ultmann, Director of TheUniversity of Chicago Cancer ResearchCenter and Professor in Medicine, spokein January on Hodgkin's Disease to theMinneapolis Blood Club and at medicalgrand rounds at the University of Minnesota. He was guest speaker at the 26thanniversary meeting of Ann LangerCancer Research Foundation in Chicagoin February, when he discussed theprogress in cancer research.He served as chairman and moderatorof the Kretschmer Symposium of"Scientific Advances Affecting theTreatment of Leukemia" held at theDrake Hotel in Chicago, February 24.The symposium was cosponsored by theInstitute of Medicine of Chicago, theChicago Society of Internal Medicine,and the American Cancer Society's Illinois Division.46 Dr. Ultmann spoke at the symposiumon Hodgkin's disease of the LeukemiaSociety of America at Mineola, NewYork, May 21. He has been named tothe board of directors of the Associationof American Cancer Institutes.Dr. James B. Wagonfeld, ResearchFellow, presented his paper entitled" Analysis of Rate Controlling Processesin Polyglutamyl Folate Absorption" atthe national meeting of the AmericanFederation for Clinical Research in Atlantic City, New Jersey, May 3 and 4.MicrobiologyGrants:Alvin Markovitz, Professor in Microbiology and the College, received a$52,056 grant to study "Regulation ofthe Gal Operon UV and X-Ray Sensitivity. "Bernard Roizman, Professor in Microbiology and Biophysics and Theoretical Biology and Chairman of the Committee on Virology, is principal investigator for an American Cancer Societygrant of $84,929 to study the"Biochemistry of Herpesviruses."Roizman presented a paper entitled"Herpes Viruses, Latency, and Cancer" at the symposium on oncogenesisMarch 17, at Purdue University. He discussed "Do Herpesviruses CauseCancer?" at a session of the Royal Society of London, June 23. He also participated in programs and conferences thisAugust in Aspen, Colorado; in the annual Gordon conferences in NewHampshire; and in an international conference in Madrid.James A. Shapiro, Assistant Professorin Microbiology and the College, has received a grant of $60,000 from the National Science Foundation to study"Genetics and Regulation of AlkaneMetabolism in Pseudomonas."Patricia Spear, Assistant Professor, isprincipal investigator for an AmericanCancer Society grant totaling $53,500 fora program entitled "Biochemical andImmunological Studies of MembraneProteins Specified by Herpesviruses."Obstetrics and GynecologyPromotions:Dr. Abdolhamid Hosseinian-Associate Professor.Dr. Alfonso Mejia-Zelaya-ClinicalAssociate (Assistant Professor).Dr. Atef H. Moawad-Professor.Grants:Dr. Marshall D. Lindheimer, AssociateProfessor in Obstetrics and Gynecologyand Medicine, has received $25,282 fromthe National Institutes of Health, (Heartand Lung Institute), to support an inter- national symposium on hypertension inpregnancy. The meeting will be held atthe University's Center for ContinuingEducation, September 25-27, and willbring together 40 scientists from theUnited States and abroad.He also received $89,265 from TheNational Institutes of Health (ChildHealth and Human Development Institute) to study renal functional correlatesof abnormal pregnancy. Drs. A. 1. Katz,Professor in the Department of Medicine, and Benjamin Spargo ('52), Professor in Pathology, are coinvestigators.Dr. Marluce Bibbo, Associate Professor in Obstetrics and Gynecology andPathology, and George L. Wied,Blum- Riese Professor in the Departments of Obstetrics, Gynecology andPathology, participated in the international conference on automation ofuterine cancer cytology held at theUniversity's Center for ContinuingEducation, April 7-10.Dr. Luis A. Cibils, Mary CampauRyerson Professor, received the firstprize award from the Central Association of Obstetricians and Gynecologistsfor a paper entitled "ClinicalSignificance of Fetal Heart Rate Patterns During Labor, 1. Baseline Patterns." He will present his paper at themeeting in Colorado Springs in September.Dr. John Esterly, Associate Professorin the Departments of Pathology andObstetrics and Gynecology, presentedpapers on the ultrastructural aspects oflung injury, and on the involution of thecorpus luteum on fetal inflammation atmeetings of the American Association ofPathologists and Bacteriologists and thePediatric Pathology Club in New Orleans.Dr. Marshall Lindheimer, AssociateProfessor in Obstetrics and Gynecologyand Medicine, was one of five expertswho participated in a workshop onhypertension in pregnancy at the MayoClinic, February 28. As the guest of theKidney Foundation of the Upper Midwest, he participated in an all-day program in Minneapolis, March 14. Histopic was" Renal Function and DiseaseDuring Pregnancy." Dr. Lindheimerparticipated in The American Society ofClinical Pathologists' postgraduatecourse on "Electrolytes, Acid-Base Imbalance and Blood Gases" in Chicago,April 28-May 2.Dr. Michael Newton, Professor, isChairman of the institutional researchgrant committee of the American CancerSociety. Dr. Newton presented a paperentitled "Radical Hysterectomy orRadiotherapy for Stage I CervicalCancer: A Statistical Comparison with 5and 10 Year Follow-up" at the annualmeeting of the American GynecologicalSociety in San Diego, California, April12. He also participated in a symposiumon "The Family-Can it be Saved?" inPhiladelphia, April 6.He has been appointed chairman ofthe ad hoc committee on by-laws of theAmerican College of Obstetricians andGynecologists and member of theAmerican College of Obstetricians andGynecologists' Committee on Liaisonwith the International Federation ofGynecology and Obstetrics. Dr. Newton is a member of the scientific programcommittee of the International Federation of Gynecology and Obstetrics forthe 8th World Congress on Obstetricsand Gynecology, to be held in MexicoCity, October 1976. He is also chairmanof the program committee of the American College of Obstetricians andGynecologists for this meeting.Dr. Gebhard F. B. Schumacher, Professor, participated in a program on"Techniques in Tissue Pathology,"March 5, at the annual meeting of theInternational Academy of Pathology,U.S.-Canada Division, in Halifax, N .S.OphthalmologyDr. Frank W. Newell, James and AnnaLouise Raymond Professor and Chairman of the Department, received an outstanding achievement award from theUniversity of Minnesota at its annualmedical school recognition program,June 6. The award is given to formerstudents of the University of Minnesotawho have attained distinction in theirfields. Dr. Newell received his M.S. degree from Minnesota in 1942, after completing his M.D. degree at Loyola in1939.Dr. Albert M. Potts, former directorof research and a member of the department since 1959, has been appointedchairman of the department of ophthalmology at the University of LouisvilleSchool of Medicine.Krill Memorial Symposium. "Advances in Retinal Diseases," a symposium in honor of Dr. Alex E. Krill,Professor in Ophthalmology (who diedDecember, 1972), was held at the PalmerHouse in Chicago, January 24 and 25. Itwas sponsored by the Krill MemorialFund and the University's Departmentof Ophthalmology. Twelve specialists inophthalmology and vision presentedpapers.The Krill Memorial Lecture was givenby Dr. Desmond B. Archer on "SomeObservations on Branch Retinal VeinObstruction." Dr. Archer is the SirCharles Blakemore Professor ofOphthalmology at The Queen's Univer- sity and consultant surgeon at RoyalVictoria Hospital in Belfast, NorthernIreland.The introductory speech was given byDr. Frank W. Newell. Faculty membersin the department who presented paperswere: Dr. Terry Ernest, Associate Professor, Dr. Albert M. Potts, and Dr.Walter Stem (,70), Assistant Professor.PathologyPromotion:Dr. Stephen A. Schwartz-Instructor.Dr. Robert Chen, Resident-Trainee,was awarded first prize in the YoungInvestigator's Competition of theAmerican College of Cardiology for hispresentation entitled "Effect of Hyperlipemia on Lipid Metabolism of RabbitAortic Medial Cells" in Houston, February 10.Dr. Robert Wissler (,48), Donald N.Pritzker Professor of Pathology and theCollege, participated in the Frontiers inBiology Sciences Lectures at CaseWestern Reserve University in March.He lectured on "The Interaction of Celland Lipoproteins in Atherogenesis" andpresented a seminar on "A Review ofthe Potential for Regression of Advanced Atherosclerosis."He also took part in the formal dedication ceremony for the National Researchand Demonstration Center in Houston,Texas, March 25. The theme of theprogram was "Current Status and Prospects in Cardiovascular Disease." Dr.Wissler discussed "Problems and Progress in Understanding ProgressiveAtherogenesis and the Prospects for Regression.' ,Dr. Wissler participated in a comprehensive course entitled, "RecentAdvances in Coronary Disease," sponsored by the University of California,Irvine, and the Pasadena ResearchFoundation in Newport Beach, California, March 27-29. He presented twotalks entitled "Interactions of Lipoprotein Fractions with Artery Wall Cells InVitro" and "Mechanism of Acute Myocardial Ischemia."He was invited to participate in theCongress of the German Society for International Medicine in Wiesbaden inApril and in a workshop meeting inHeidelberg.At the 27th annual meeting of theAmerican Association of Pathologistsand Bacteriologists in New Orleans,March 4, Dr. Wissler presented hispaper entitled "A HistopathologicalStudy of the Fatty Streak in Aortas andCoronary Arteries of Young AmericanMilitary Personnel." Co-authors on thiswork are Dr. Dragaslava Vesselinovitch, Research Associate (Assis- tant Professor), and Dr. Hugh McAllister, chief of the division of cardiovascularpathology at the Armed Forces Instituteof Pathology, at Walter Reed MedicalCenter in Washington, D.C.PediatricsPromotions:Glyn Dawson-Associate Professor.Glyn Dawson, Associate Professor,was the invited speaker at the symposium on inborn errors of metabolismin Milan, Italy, April 11-12. He alsospoke at several Universities in Germany, and in England at Oxford and atthe University of Bristol.Dr. Albert Dorfman, the Richard T.Crane Distinguished Service Professorin Pediatrics, and Professor "inBiochemistry and the Committees onGenetics and Developmental Biology,was the invited speaker at the EuropeanMolecular Biology Organization workshop on "Membrane Dynamics CellRegulation" in Eliat, Israel, April30-May 3. The title of his talk was' 'TheRegulation of Proteoglycan Synthesis."Dr. Dorfman, who is Director of theJoseph P. Kennedy, Jr. Mental Retardation Research Center, delivered theGrover Powers Memorial Lecture atYale University, New Haven, Connecticut, May 21. The subject was,"The Enzymic Defects of Mucopolysaccharidoses." In June, he participated in the Benjamin Knox RachfordMemorial Lectureship at the Children'sHospital Research Foundation inCincinnati. In a symposium on "MentalRetardation" he discussed "Recent Advances in the Causation ofCentral Nervous System DisordersLeading to Mental Retardation" and"Metabolic Basis of Mental Retardation." From July 6-12, he attended thethird international meeting on glycoconjugates at the University of Sussex,Brighton, England. He spoke on "TheEnzymic Defects in Maroteaux-Lamyand Morquio's Disease."Dr. Burton J. Grossman (,49), Professor in LRUCI and in Pediatrics, presented a lecture on "JuvenileRheumatoid Arthritis" to the IllinoisPediatric Society, April 2.Dr. Peter R. Huttenlocher, Professor,presented a paper entitled "InfantileDiffuse Cerebral Degeneration withHepatic Cirrhosis" at the 27th annualmeeting of the American Academy ofNeurology, Bal Harbor, Florida, May 1.Dr. John F. Kenward, Associate Professor in Pediatrics and Psychiatry, andDirector of Child Psychiatry, was invited to lecture in Colombia, SouthAmerica in February. He conductedseminars for the psychiatric residents47and staff at the University Hospital inCali and in Bogota. He was guestspeaker at a special meeting of the Colombian Psychoanalytic Society.Dr. Christian L. Rieger, AssistantProfessor, talked on "Medical Aspectsof Immunology," April 22, at the Pediatric Intensive Care Symposium inChicago.Dr. Samuel Spector, Professor andChairman of Pediatrics and Director ofLRUCI, was visiting professor ofpediatrics at the Medical College ofGeorgia, March W-14. He led teachingrounds at the University Hospital and atTalmadge Hospital and presented agrand rounds lecture on, "Failure toThrive."Dr. A. C. Stoolmiller, Assistant Professor, was elected a member of theAmerican Society for Neurochemistry,March 12. He also presented a scientificpaper during the 6th meeting of the society in Mexico City, March 10-14.Dr. Paul Weiner, Associate Professorin Pediatrics and Psychiatry, wrote anarticle on "The Standardization ofTests: Criteria and Criticisms" for theJournal of Speech and Hearing Research, Volume 16:1975.Two hundred pediatric and intensivecare nurses from across the country attended a comprehensive two-day pediatric intensive care symposium, April 21and 22, sponsored by the Wyler Pediatric Nursing Department. The programincluded lectures and panel discussionson many facets of the care of critically illchildren and enabled participants toidentify new approaches and update personal knowledge in pediatric intensivecare nursing.Pharmacological and PhysiologicalSciencesDr. Leon I. Goldberg, Professor inPharmacological and Physiological Sciences and Medicine, and Chairman ofthe Committee on Clinical Pharmacology, was chairman of the cardiovascularpanel at a meeting of the United StatesPharmacopeia, SCOPES committee, inSan Diego, January 11-14. This committee chooses the drugs which will be included in the United States Pharmacopeia. He also spoke on "Regulation of Clinical Pharmacology,Academic Point of View" at the annualmeeting of the Pharmaceutical Manufacturers Association, Marco Beach,Florida, May 4.Dr. Paul Grobstein, Assistant Professor in Pharmacological and Physiological Sciences, lectured on "The Role ofVisual Experience in the Developmentof Mammalian Receptive Field Organi-48 zation" at the University of Rochester,April 15.PsychiatryPromotions:Dr. Henry M. Evans-Associate Professor.Dr. Patrick H. Hughes-AssociateProfessor.Dr. Sheppard G. Kellam-Professor.Dr. Nathaniel Apter, Professoriallecturer, and Dr. Edward Wolpert (,60),Director, Clinical Services, MichaelReese Hospital PsychosomaticPsychiatric Institute and Clinical Associate Professor, were elected councilors of the Illinois Psychiatric Society.Dr. Pieter de Vryer, Associate Professor and Director of the Nicholas J.Pritzker Children's Hospital and Center,was honored, May 7, at the TravelersAid Society/Immigrants' ServiceLeague's fifteenth annual award dinnerfor outstanding contributions to his profession, community and country. AtPritzker Children's Hospital, Dr. deVryer developed a comprehensive program of service to children withpsychological problems and theirfamilies. It serves as a model in the fieldof child psychiatry.Dr. Jarl E. Dyrud, Professor and Director of Clinical Services in the Department of Psychiatry, participated in apanel on "The Language of Ritual andDivination as an Art Form in Africa andin American Society and Its Relationship to the Healing Community" duringThe University of Chicago LanguageCelebration, May 8-9. Dr. Dyrud discussed the relation of ancient socialmedicine to contemporary medical practice.Dr. Lawrence Z. Freedman, Foundations Fund Research Professor, delivered two papers during April at the 39thannual meeting of the Midwest Sociological Society in Chicago, and a paper onalcoholism among former heroin addicts(who are participants in the methadonemaintenance-detoxification program) atthe sixth annual medical-scientific session of the National Council on Alcoholism in Milwaukee, April 28-29.Dr. Robert Holt, a third-year Resident, is the 1975 winner of the international Taylor Manor Hospital EssayA ward for the best essay on the future ofpsychiatry. Dr. Holt read his entry,"The Future of Psychiatry: AResident's Perspective," at the seventhannual Taylor Manor Hospital psychiatric symposium in Ellicott City, Maryland, April 5, and received the $250 prize.Dr. Chase P. Kimball, Associate Professor in Psychiatry and Medicine, hasbeen elected a fellow of the Institute of Medicine of Chicago. As a councilor ofthe American Psychosomatic Society,he organized the society's first continuing education program in psychosomaticmedicine at the annual meeting in NewOrleans, March 20-24. At the annualmeeting of the American Psychiatric Association in Anaheim, California, May5-9, Dr. Kimball led a discussion on"Research and New Dimensions inLiaison Psychiatry."RadiologyAppointment:Dr. Jeannie Kinzie-Assistant Professor.Lawrence H. LanzI, Professor inRadiology and the Franklin McLean Research Institute, was invited by theTurkish Atomic Energy Commission togive several lectures at the Nuclear Research Centre in Ankara, and at theCekmece Nuclear Research Institutenear Istanbul. He spoke on radiationdosimetry research, including his workon californium-252 as it pertains toradiobiology and therapy. He also assisted the dean of the Ankara UniversityMedical School in developing a graduateprogram in health and medical physics.Dr. Stan D. Vesselinovitch, Professorin Radiology, Pathology, the FranklinMcLean Memorial Research Institute,and Director of the Section of RadiationBiology and Experimental Oncology,has been elected the recipient of theAlexander von Humboldt "Senior U.S.Scientist Award." The award honorsAmerican scientists who have gained aninternational reputation and promotesthe interchange of ideas in specifiedfields between German and Americanresearchers and research institutions.The award is granted in recognition ofthe scientist's accomplishments in research and teaching.He was an invited speaker at the thirdannual carcinogenesis collaborative conference of the National Cancer Institute,Division of Cancer Cause and Prevention, held at Orlando, Florida. He spokeon "Factors Modulating Benzidine Carcinogenecity Bioassay." He also spokeon "Hepatocarcinogenesis in the Mouse"at a meeting on the evaluation of thehepatoma in the rodent in carcinogenesisbioassay held at the National Center forToxicological Research, Jefferson,Arkansas. Both meetings were held inFebruary.Two papers were presented at an international symposium on advance inbiomedical dosimetry (sponsored by theInternational Atomic Energy Agency inVienna, Austria, March 10-14,) bymembers of the department and theFranklin McLean Memorial ResearchInstitute: "Image Quality and PatientExposure in Mammography, Tomography, Angiography and Bone Radiography" by Arthur G. Haus (presenter),Research Associate, Kurt Rossmann,Professor, and Kunio Doi, AssociateProfessor (also from the Center forRadiologic Image Research); "A Precise Method for Measuring the NeutronResponse of a Neutron-IntensiveDosimeter" by Franca T. Kuchnir (presenter), Associate Professor, Lester S.Skaggs, Professor, and Carl J. Vborny,graduate Research Assistant.SurgeryPromotion:Dr. Javad Hekmatpanah-Professor.Dr. Warren Enker, Assistant Professor, presented a paper entitled "TheActive-Specific Immunotherapy of SolidMalignant Neoplasms-A Concept withRelevance to Lymph Node PositiveColon Cancer" at the Chicago SurgicalSociety program, February 7.Dr. William Gill, Associate Professor(Urology), presented the following papers at the 70th annual meeting of theAmerican Urological Association held inMay in Miami Beach: "Studies on theMetastable Limits for SpontaneousNucleation-Crystallization of UrinaryCalcium Oxalate" and" RetrogradeRenal Brushing as an Aid in the Evaluation of Renal Parenchymal Masses."Coauthors were Dr. Marluce Bibbo, Associate Professor in Obstetrics andGynecology and Pathology; Dr. SharonThomsen, Assistant Professor inPathology; and Dr. Chien-tai Lu, Assistant Professor in Radiology. Dr. Gillwas named an assistant editor of TheJournal of Urology.Dr. Stuart Landa, Associate Professor, is a member of the American Association of Plastic Surgeons and theAssociation Francaise des ChirurgiensMaxillo-Faciaux (French Association ofMaxillo-Facial Surgeons). He is the onlyAmerican member of the French society.Dr. A. R. Moossa, Assistant Professor; Dr. A. W. Hall, Instructor; and Dr.David B. Skinner, Dallas B. PhemisterProfessor and Chairman of Surgery, presented a paper entitled' 'The Effects ofPremedicating Drugs on Gastroesophageal Motility and Reflux Statusof Rhesus Monkey and Man" at a meeting during Digestive Disease Week,May 19-22, in San Antonio.Dr. Ramon Lim, Assistant Professorin Neurosurgery and Biochemistry,spoke at Harvard University on "Morphological Transformation of EmbryonicBrain Cells in Culture," and at the University of Illinois Medical Center on "Immunological and BiochemicalStudies of AP22, a Brain-Specific Protein," in February. He also participatedin three programs at the sixth meeting ofthe American Society for Neurochemistry held in Mexico City, March 10-14. InMay, he spoke at NorthwesternUniversity's department of anatomy.Dr. Heman Reyes, Associate Professor in Surgery (Pediatrics), is testing asilicone rubber tube insert for theesophagus in cases where children havesuffered severe esophageal bums fromswallowing acid or alkaline compounds.Dr. David B. Skinner was host for themusculo-skeletal and general surgerymeeting of the Chicago Committee onTrauma of the American College ofSurgeons held in Billings Hospital, February 18. Dr. Edwin L. Kaplan, Associate Professor, and Dr. Gerald S.Laros, Professor and Chairman of theOrthopedics Section, were moderatorsof the program. Dr. Skinner has beenappointed to the Biomedical ResearchPanel by President Ford. Established byCongress under Title II of the NationalCancer Act Amendments of 1974, thenine-member panel will undertake a15-month in-depth review of biomedicaland behavioral research programs conducted and supported by the Department of Health, Education, and Welfare.Section of OtolaryngologyDr. Gregory Matz, Associate Professorof Surgery (Otolaryngology), waselected a fellow of the American Laryngological, Rhinelogical and OtologicalSociety at the annual meeting in Atlanta,Georgia, April 8. Dr. Matz also receivedthe Edmond Fowler Award, given inrecognition of excellence in basic research, for his candidate's thesis.ZollerDr. Robert A. Goepp, Associate Professor in the Zollar Dental Clinic (ZDC)and in Pathology, is the author of' 'YourDental Health," a monthly column inToday's Health, published by theAmerican Medical Association. His firstcolumn appeared in the May issue. Healso presented a seminar entitled "Perspectives in Dental Radiology, Sialography" at the annual meeting of theAmerican Academy of Oral Pathology inKansas City in April.Dr. Thomas M. Graber, Professor inZoller Dental Clinic, Pediatrics, and Research Associate in Anthropology, received the Albert H. Ketcham Awardfrom the American Association ofOrthodontists at the association's 75thanniversary meeting in Las Vegas, April20. The award was given for the year'sgreatest contribution in research and teaching." He also was the keynotespeaker; his address was entitled "AnOrthodontic Perspective after 75Years." He is the coauthor of a newtwo-volume textbook entitled Orthodontics, Current Concepts and Technics(with Dr. B. F. Swain, University ofPennsylvania) which has been publishedby W. B. Saunders, Philadelphia, 1975.George W. Barnhart, Master Dentaland Maxillo-Facial Prosthetic Technician and Supervisor of the ProstheticLaboratory, died June 21 at the age of57. He had been with Zoller Clinic 25years. Last year, he was awarded theExalted Order of the Bumblebee by theAmerican Academy of Plastic Researchin Dentistry.Michael Reese-PritzkerThe following full-time members ofMichael Reese Hospital and MedicalCenter have been named to the staff ofThe Pritzker School of Medicine andZoller Dental Clinic:Department of AnesthesiologyReappointments:Dr. Roger F. Bonnet, Professor, fortwo years, effective March 1, 1975.David J. Miletich, Assistant Professor, for two years, effective March 1,1975.Dr. Ronald Rosenberg, AssociateProfessor, for two years, effective February 1, 1975.Dr. Edward T. Toyooka, AssociateProfessor, for two years, effectiveMarch 1, 1975.Dr. Behrooz Zahed, Associate Professor, for two years, effective March 1,1975.Department of MedicineAppointments:Dr. Juan Engel to Assistant Professor,for two years, effective January I, 1975.Promotions:Dr. Harold .Klawans to Professorfrom Associate Professor, for two years,effective January 1, 1975.Dr. Mabel Koshy to Assistant Professor from Instructor, for two years, effective July 1, 1975.Reappointment s:Dr. Juan Chediak, Instructor ofMedicine, for one year, effective July 1,1975.Dr. Sidney Cohen, Professor, for twoyears, effective January I, 1975.Dr. Lawrence Frohman, Professor,for two years, effective July I, 1975.Dr. Ernest Mond, Clinical AssociateProfessor, for two years, effective December I, 1974.49Dr. Alfred Pick, Professor, for oneyear, effective July 1, 1975.Department of PsychiatryPromotions:Dr. Harold Klawans to Professorfrom Associate Professor, for threeyears, effective January 1, 1975.Reappointments:Dr. Roy R. Grinker ('21), Professor,for two years, effective July 1, 1975.Dr. Lawrence Kay ton, Assistant Pro- fessor, for two years, effective July 1,1975.Dr. Daniel Offer ('57), Professor, fortwo years, effective July 1, 1975.Zoller Dental ClinicAppointments:Dr. Benjamin J. Gans to Clinical Professor of Oral Surgery, for two years,effective March 1, 1975.Dr. Charles S. Greene to Clinical Associate Professor, effective March 1,1975.Alumni News1901Noble W. Jones died February 7, 1975.Dr. Jones was an annual contributor tothe Medical Alumni Fund until hisdeath. He would have been 100, June 13,1976. Dr. Jones was a gastroenterologistat the University 'of Oregon MedicalSchool from 1920-1947 when he becameprofessor emeritus.1915Leon Unger of Chicago received a "Fellow Distinguished Award" from theAmerican College of Allergists, March19, 1975.1926Theodore J. Smith was re-elected president of the Sarasota- Bradenton (Florida)retired doctors' club. He has lectured totwo lay groups on: "Medical Uses ofHypnosis. "1932Nathaniel E. Reich of Brooklyn, NewYork, who has been listed in "Who'sWho in America" since 1962, is includedin the second edition of "Who's Who inthe World." He was recently elected afellow of the Royal Society of Medicine.He holds fellowships in five other professional societies.Lois Carolyn Wyatt, Kirkwood, Missouri, is president of the MissouriAcademy of Family Physicians.1934Vida H. Gordon retired January 1 as50 professor of pediatrics and associate professor of microbiology at the Universityof Arkansas Medical Center. She is continuing her studies of allergies.1935William E. Taylor has retired as directorof the Taylor Health Center, SouthwestMissouri State University, Springfield,Missouri, after 39 years as physician anddirector of the college health service.1936Karl P. Classen, professor of surgeryand director of the division of thoracicsurgery, Ohio State University, andchairman of the department of thoracicsurgery, Children's Hospital, Columbus, was honored by the MedicalSchool. The Karl P. Klassen Chair inThoracic Surgery was establishedthrough a bequest of Frederick E. Jones,a prominent Columbus businessman.Oscar Bodansky has been a visitinginvestigator at Rockefeller Universitysince July 1, 1973. He retired fromMemorial Sloan-Kettering CancerCenter, in 1971. His book, Biochemistryof Human Cancer, was published byAcademic Press this March.Charles H. Rammelkamp of Cleveland was awarded an Honorary Doctorof Science degree at the June commencement of Northwestern University.1942Robert Ebert, dean of the Harvard Medical School, was among those appointed to the Presidential Panel on BiomedicalResearch. He will serve as cochairmanof the panel. Dr. David Skinner, chairman of the University'S Department ofSurgery, and Dr. Albert Lehninger (BenMay Laboratory, 1945-1952) also aremembers.1944David T. Hellyer, a Tacoma, Washington naturalist and retired pediatrician,received The University of Chicago'sPublic Service Citation at the June 7awards ceremony, for enriching the lifeof his community. He founded Northwest Trek, a natural habitat wild lifepark of nearly 60 acres near Tacoma.Once ravaged by fire, the land wasnursed back to a state of flourishing wilderness by the Hellyers. His gift of theland to the Park District was supplemented by his efforts to guarantee theuse of the area for the preservation ofnative Northwest and Alaska wildlife.1945Warren F. Wilhelm, Shawnee Mission,Kansas, is chief of staff of the ResearchMedical Center. He is also president ofthe 1, 100 member Jackson County Medical Society (Missouri).1947Edyth H. Schoenrich has been appointed professor in the department ofpublic health administration at the JohnsHopkins School of Hygiene and PublicHealth. She has resigned as director ofthe Administration for Services to theChronically III and Aging for the State ofMaryland. She is chairman of the board.of trustees of the Commission on Accreditation of Rehabilitation Facilities; isa member of the board of trustees of theAmerican Board of PreventiveMedicine; is a fellow of the AmericanCollege of Physicians; is on the board ofdirectors of the Baltimore City MedicalSociety and the Governor's Commissionon Kidney Disease.1948Robert T. S. Jim was appointed associate professor of medicine at the newUniversity of Hawaii School ofMedicine. He was recently certified bythe American Board of InternalMedicine in the subspecialty of hematology.1950Mortimer D. Gross of Highland Park,Illinois, organized and became directorof the diagnostic center of SummitSchool two years ago. The school is forchildren with learning disabilities. "Minimal Brain Dysfunction," a clinicalstudy of more than 1,000 children, written by Dr. Gross and W. C. Wilson, waspublished last year.1951Robert J. Wirtshafter has been appointed assistant professor at Rush Medical College, Chicago.1953H. Hugh Fudenberg has moved toCharleston, South Carolina, to becomechairman of the new department of basicand clinical immunology and microbiology at the Medical University of SouthCarolina.1954David L. Rosenberg was elected to atwo-year term as councilor of the IllinoisPsychiatric Society (IPS); has beencertified by the American Board ofPsychiatry and Neurology; serves on thefaculty of the Abraham Lincoln Schoolof Medicine (Chicago); and is a consultant to the Highland Park Hospital andthe Illinois State Psychiatric Institute.1956C. Peter Rosenbaum, associate professor of psychiatry at Stanford University,is coauthor with John E. Beebe III (,65),of Psychiatric Treatment: Crisis, Clinical and Consultation, published by theMcGraw-Hill Book Company, April1975. It is a basic text for psychiatricresidents, medical students and otherbeginning mental health professionals.1958A. Yvonne Russell is associate dean andclinical professor of pediatrics and family, community and preventive medicine,at Stanford University School ofMedicine. She also is director of medicalinstitutions at Santa Clara Valley Medical Center.James A. Survis is a pathologist atFort St. John General Hospital, Fort St.John, British Columbia.1959Richard L. Grant is associate professor,department of psychiatry, University ofColorado Medical Center and project director, NIMH Grant, on the ProblemOriented System in Psycho-social Care.1960Donald Fischer has been appointed physician-in-charge at the Kaiser/Permanente Medical Group, Richmond,California. Dr. Fischer joined the groupin 1966 and has served as chief ofmedicine since 1969, and as assistantphysician-in-charge since July, 1972.Robert A. Moody is professor ofneurosurgery at the Abraham LincolnSchool of Medicine at the University ofIllinois, and chairman of the departmentof neurosurgery at Cook County Hospital.1961Hallie Moore is staff psychiatrist at TheInstitute of Living, Hartford, Connecticut, and a member of the committee onethics of the American Psychiatric Association.1962Julian Katz is associate professor ofmedicine at the Medical College ofPennsylvania. His wife, Dr. SheilaMoriber Katz, is assistant professor ofpathology at Hahnemann MedicalSchool.1963Thomas Borden is chief of urology at theUniversity of New Mexico, Albuquerque.Dirk V. DeYoung, staff physician atthe University Health Services, diedFebruary 1,1975 in Billings Hospital. Hisfamily gave his collection of 4,000 classical records for student use to studentoperated radio station, WHPK-FM.1965John E. Beebe Ill, California psychiatrist, has written Psychiatric Treatment:Crisis, Clinic and Consultation, with C.Peter Rosenbaum ('56).Nicholas A. Vick (Intern, residentand faculty, '65-'75) is associate professor of neurology at Northwestern University School of Medicine, and head,division of neurology at Evanston Hospital. His book, G rinker's Neurology(7th edition), will be published this fallby Charles C. Thomas.1966Michael L. Brownstein is in privatepractice of plastic and reconstructivesurgery in association with Dr. WilliamJ. Morris and Dr. John Q. Owsley, Jr. inSan Francisco.Jay DeVore has returned to Chicagoto become assistant professor of anesthesiology and obstetrics and gynecology at Northwestern University MedicalSchool and director of anesthesiology atNorthwestern's new Prentice Women'sHospital and Maternity Center. Edward T. Haines has opened anoffice for general surgery in Truth orConsequences, New Mexico. He alsoserves as general surgery consultant tothe Carrie Tingley Hospital for CrippledChildren.Donald R. Hopkins is assistant professor of tropical public health at Harvard School of Public Health.David G. Ruschhaupt is in the division of pediatric cardiology at UniversityHospital of Jacksonville, Florida.1968Stanley W. Coulthard is assistant professor of otolaryngology at the University of Michigan Hospital.Burr Eichelman completed his residency in psychiatry this June. He wasawarded a Kennedy Fellowship inMedicine, Law and Ethics at StanfordUniversity Medical Center to study theissues of law relating to the treatmentand research of the mentally ill and mentally retarded. This past year he waschief resident and acting assistant director of the adult psychiatry clinic at Stanford.Gurdon H. Hamilton is a general internist in Portland, Oregon and preceptor at Good Samaritan Hospital, anaffiliate of the University of Oregonprogram for students and residents.Dominic C. M. Kam is attendingsurgeon at the Kaiser/Permanente Medical Center in Panorama City, California.Paul J. Schechter is working in Strasbourg, France as chief of the experimental therapeutics section at Merrell International Research Center.Jerrold M. Stock completed two yearsof active duty in the U.S. Army at FortGordon, Georgia and has joined an established endocrinologist in the privatepractice of internal medicine and endocrinology in Morristown, New Jersey.1969Thomas H. Jobe completed his militaryobligations (Berry Plan) in the Navy atGreat Lakes Naval Regional MedicalCenter in July. He was director of outpatient psychiatric services and the recruitevaluation unit. He will enter the MorrisFishbein Center for the Study of the History of Medicine and Science at The University of Chicago in September and willconcentrate on the history of medicalpsychology.1970Jeffrey Coe has recently returned to theU.S. after studying tropical medicine inLondon and Indonesia. He is instructorin ambulatory and preventive medicineat the New York Medical College andassistant director of the ambulatory and51preventive medicine department of B.S.Coler Memorial Hospital. He hopes toreturn to Asia in the near future.1971Kevin G. Geyer will begin a privatepractice in ophthalmology in Santa Barbara, California in September while hiswife, Delores, completes her educationat the University of California at SantaBarbara. They have two children,Matthew, 5, and Robin, 3.1972Melvin H. Cole died in an auto accidentin New Haven on April 13, 1975 at theage of 28. He was finishing his secondyear residency in psychiatry at the YaleUniversity Medical School.Paul A. Gallagher has moved to SanLuis Obispo, California, and is a familypractitioner in the French MedicalClinic.Thomas E. Gift is a resident in the department of psychiatry at Strong Memorial Hospital, Rochester, New York.Kenneth D. Krantz is associate director of general medicine and neuropsychiatry clinical research at SearleLaboratories, Chicago.Former StaffDr. Huberta Livingstone Adams(Surgery, Intern, Resident and Fellow,'28-'33; Surgery and Anesthesiologyfaculty, '35-'52) was featured in a storyin the Cedar Rapids Gazette, May 18.Dr. Adams is the widow of Dr. WilliamE. Adams, former Chairman of Surgeryat the University. The article also referred to her home in Hopkinton, Iowa.The house, built in 1897, was owned byMrs. Adams's father, Dr. Hugh Livingstone, an 1890 graduate of Rush MedicalCollege, Chicago. Dr. Adams and herhusband made many lecture trips abroad,gathering mementos now displayedthroughout the house. Many of the itemswere gifts from students and friends. Oneprize item is a birdhouse in the shape ofa church. An 18th Century spinningwheel, made in Scotland and brought toCanada by Huberta Adams' greatgrandparents in 1816, stands in front ofthe fireplace.Because her husband spent much timein Mexico training doctors, Mexico became a second home to the Adams family. Mrs. Adams still visits Cuernavacaeach year, working with the World Association of Girl Guides and GirlScouts.B. H. Athreya (Pedatrics, resident,'60-'62), clinical director at Children'sSeashore House in Atlantic City, New52 Jersey, was appointed project director ofthe regional pediatrics arthritis program.He is the author of Differential Diagnosis in Pediatrics Card-Son-System ofSymptom Analysis, published by W. B.Saunders and Company.Arnold R. Axelrod (Medicine, intern,'44-'45) is chairman of the department ofmedicine at Sinai Hospital of Detroit.William R. Barclay (Medicine,'48-'49; '51-'65) has been appointededitor of lAMA, the Journal of theAmerican Medical Association. Hejoined the American Medical Association in 1970 as assistant executive vicepresident, a post he continues to hold inaddition to the editorship oUA MA.Jerome Burke (Hematology, fellow,'71-'73) is assistant professor of pathology at M. O. Anderson Hospital andTumor Institute at Texas MedicalCenter in Houston.Robert S. Daniels (Psychiatry,'57-'71) was appointed dean of the University of Cincinnati College ofMedicine. He served as interin deansince 1973. Dr. Daniels is a fellow of theAmerican College of Psychiatrists andpresident of the Cincinnati Psychoanalytic Society.Dr. Edgar Draper (Psychiatry, faculty, , 59-'68) was appointed chairman ofthe department of psychiatry at the University of Mississippi. Dr. Draper hasbeen professor of psychiatry at the University of Michigan Medical Center.Dr. Jay J. Jacoby (Surgery, faculty,'46-'47: Ph.D. '47) was selected the outstanding teacher in the medical school atJefferson Medical College of ThomasJefferson University. It is the highesthonor for a faculty member. His portraitwas presented to the college by thesenior class, May 9. Dr. Jacoby is professor and chairman of the department ofanesthesiology. He is a diplomate of theAmerican Board of Anesthesiology andof the American College of Anesthesiology.Norman Jesberg (Pathology, internand resident, '43-'45) is associate clinical professor of surgery (otolaryngology)at the University of Southern CaliforniaSchool of Medicine. He also is on thestaff of the Hospital of the Good Samaritan in Los Angeles.Philip M. Margolis (Psychiatry, faculty, '56-'66) of Ann Arbor, Michigan ischairman of the consultation and evaluation services board of the AmericanPsychiatric Association.Bruce Proctor (Otolaryngology, intern, resident and faculty, '37-'41) hasbeen elected to the board of directors ofthe Deafness Research Foundation. Heserves on the board of governors of theWilliam Beaumont Hospital Research Dr. Jay JacobyInstitute and is chief of the departmentof otolaryngology at Detroit Memorialand South Macomb Hospitals.Theodore Rasmussen (Neurosurgery,faculty, '47-'54) delivered the Dallas B.Phemister lecture at The University ofChicago, February 25. His topic was"Current Problems and Prospects in theSurgical Treatment of Epilepsy," a subject on which he is an international authority. Dr. Rasmussen is professor ofneurosurgery at McGill University andformer director of the MontrealNeurological Institute.Jesus Saldamando (Anesthesiology,resident, '48-'50), professor of anesthesiology at the University of Guadalajara, Mexico, has been appointed amember of the scientific committee forthe Sixth World Congress of Anesthesiology to be held in Mexico City,April 26-30, 1976. The Society of Anesthesiologists of Jalisco, Mexico, ofwhich he was a founder, now has 53members.Heinrich Siedentopf (Obstetrics andGynecology, resident, '32-'33), professor in the department of obstetrics andgynecology at the Universitat Munster,4970 Bad Oeynhausen, Germany, writeshe enjoys keeping informed throughMedicine on the Midway.Jerry E. Sims (Pathology, intern andresident, '71-'75) is staff pathologist atFort Carson Air Force Base, Fort Carson, Colorado.Sukhdev Chand Soni (Radiology, resident, '69-'70) has been appointed director of the radiation therapy department at St. Joseph Hospital, Joliet, Illinois.Paul G. Stimson, (Zoller, intern andfellow, '61-'65; M.S. '66) is associateprofessor in dental pathology at the University of Texas Dental Branch in Houston. Last year he lectured on forensicodontology: in London at the Federation Dentaire International meeting; inAlaska; and in Mexico City. Each year,he teaches forensic odontology at theannual A.F.I.P. course. Dr. Stimsonidentified 14 of 27 Houston mass murdervictims by dentistry only.Harwell Wilson (Surgery, resident andfaculty, '32-'39), professor of surgery atthe University of Tennessee in Memphis, was given the distinguished serviceaward of the Tennessee State MedicalAssociation at its annual meeting. Theaward was given in recognition of outstanding contributions to surgical education and patient care. In 1973, the Annual Harwell Wilson Surgical Lecturewas established at the University ofTennessee in his honor. Last year, hereceived the distinguished service awardfrom the Memphis-Shelby County Med-ical Society. .Area Loan Funds EstablishedTwo alumni have established loan funddrives for the 1975 Medical AlumniFund. Dr. J. Alfred Rider ('44), SanFrancisco gastroenterologist, is settingup a Northern California Loan Fund andDr. Everett H. Given, Jr. ('59), Colorado Springs physician, is working inthe Colorado area. All new or increasedcontributions to these funds qualify formatching funds by the Anderson Challenge Gift. MAA Officers 1975-1976Officers of the Medical AlumniAssociation for 1975-76 are:PresidentDr. Henry P. Russe ('57),Chairman, Department of MedicineColumbus-Cuneo-Cabrini MedicalCenterFaculty 1963-70 Department ofMedicinePresident ElectDr. Asher J. Finkel ('48),Director, Division of ScientificActivitiesAmerican Medical AssociationVice PresidentDr. Myron M. Hipskind (HouseStaff, '33-'37)Private Practice of OtolaryngologySecretaryFrancis H. Straus II (M.S. '57),Associate Professor, Departmentof PathologyThe University of ChicagoFor the Council:1975-1978Dr. Howard L. Bresler ('57),Instructor, Department ofMedicineUniversity of IllinoisDr. Randolph W. Seed (M.D. '60,Ph.D. '65),Chairman, Department of SurgeryGrant Hospital, ChicagoAssistant Professor, Northwestern University Medical School Alumnus Establishes FundDr. Daniel Black ('47), orthopedicsurgeon in Des Plaines, Illinois, has established the Josephine Victoria Blackresearch fund at our university to support basic research of the causes, prevention and cure of lymphoma and related diseases of the blood-forming tissue. The fund is named in memory ofDr. Black's mother.CalendarFriday-Sunday, September 19-21Fall weekend at Pheasant RunLodge, St. Charles, Illinois.Write to the Medical AlumniOffice for details.Wednesday, October 15Reception for alumni and spousesduring American College ofSurgeons Meeting, San Francisco,The Stanford Court on Nob Hill,Gold Room, 5:30 to 7:00 p.m.Saturday, November 8Scientific Program and Dinnerhonoring Dr. Leon O. Jacobsonsponsored by the Council for theBiological Sciences. For information, call 947-5271.Monday, December 1Reception for alumni and spousesduring American Medical Association Clinical Meeting, Honolulu.Details can be obtained at theAMA registration desk.53A Challenge to Chicago's AlumniTo increase givingto the University by $1,000,000 this yearEvery alumnus who increases the size ofhis gift to the University or to his professional school this year will accompl ishhis purpose twice over. Every dollar ofincrease in 1975 over 1974 will represent two dollars of income to the University. Alumni who did not contributeto the University or to their schools in1974 will have their entire 1975 giftsdoubled.Each of these dollars of 1975 gift willrepresent two dollars of income to theUniversity because of a matching fundcreated by Robert o. and Barbara Anderson. Mr. Anderson is a trustee of theUniversity; he and Mrs. Anderson areboth alumni. They have established theRobert o. and Barbara Anderson Challenge Gift-amounting to $1,000,000.-to dramatize the importance of annual support of the University byalumni during the Campaign forChicago, Phase 2, and to encouragetheir fellow alumni to give or reviseupward their contributions to that vitaleffort to back up the campaign.The Andersons' Challenge fund willmatch every dollar of new giving, or ofincreased giving, by anyone person, up to $25,000 and payable within twelvemonths.Alumni of the College, the Division ofthe Biological Sciences, the Division ofthe Physical Sciences, the Division ofthe Social Sciences, the Division of theHumanities, the Divinity School, thePritzker School of Medicine, the LawSchool, the Graduate School of Education, the Graduate Library School, theSchool of Social Service Administrationand the Graduate School of Businessare eligible to make Challenge contributions.The Pritzker School of Medicine will bethe direct recipient of the increasedalumni giving and the correspondingportion of the Anderson Challenge Gift .These funds help constitute the MedicalAlumni Fund which provides the medical school with the flexibility to supportcertai n new programs and researchprojects.Capital contributions to the campaignare not eligible.' Gifts from alumnirelated foundations will be consideredon an individual basis.A RARE OPPORTUNITY TO DOUBLE YOUR ALMA MATER'S INCOME.SHE NEEDS IT.· .. And A Fond FarewellAt 2:00 a.m., during a midwest blizzard, a little childawakened crying, with sore throat, vertigo, delirium anda temperature of one hundred and five. An emergencycall to Billings Hospital quickly brought a young physician dressed in the white suit of an intern, handsome as aNordic God. A thorough bedside examination, culturestaken, sulfanilamide administered, and the anxious parents were comforted; no fee could have been excessivebut none was asked or accepted. By morning things werebetter. It was Medicine at its best. The parents werebankrupt in gratitude-we know, for the child wasours-and the young doctor was Leon Orris Jacobson,destined for greatness as physician, investigator, teacherand administrator.A teacher must never acknowledge that he has favoriteclasses of medical students; I refuse to admit it but I cansay that the Class of 1939 was keen, enthusiastic, amiableand clever. It was a vintage year with much gaiety associated with the serious and arduous business of pursuing Ars Medica. Much of the Class sparkle and drivederived from him who was ordained to be our GreatDean.Born in Sims, North Dakota (population 300), December 16, 1911, Leon Jacobson grew up in a farmingcommunity and, as a young man, spent three years teaching in a country school. In 1974, Leon Jacobson Day wascelebrated in North Dakota. He was graduated B.Sc.with honors from North Dakota State University, 1935;M.D., with honors and AOA, University of Chicago,1939. He is married to the former Elizabeth Louise Benton and they have two children, Eric and Judith. Mrs.Jacobson has contributed decisively to the happiness ofher husband; she has provided a good home famous forcalmness, hospitality, warmth and grace.The entire career of Leon Jacobson has been at TheUniversity of Chicago. 'He served an internship andcompleted residency training at the University Clinicsand joined the Faculty: Instructor in Medicine, 1942-45;Assistant Professor, 1945-48; Associate Professor,1948-51; Professor, 1951-1965; Joseph Regenstein Professor of Biological and Medical Sciences in the PritzkerSchool of Medicine and the Division of Biological Sciences, 1965-; Director of Health, Plutonium Project,Manhattan District, 1943-46; Director, Argonne CancerResearch Hospital operated by the University ofChicago for the U.S. Atomic Energy Commission,1951-65; Associate Dean, Division of Biological Sciences, 1948-51; Dean ofthe Division, 1965-75; Director,Franklin McLean Institute, 1975-.In 1943, together with Clarence Lushbaugh and E. S.Guzman Barron, Dr. Jacobson introduced nitrogen mustard (HN2) as a treatment of Hodgkin's disease. Thiswork, together with independent work at Yale andMemorial Hospital on HN 2, did much to promote interest in tumor chemotherapy.In 1949, Dr. Jacobson showed that the shielding ofnormal blood forming tissue of otherwise lethally irradiated mice, or the injection of splenic or embryonicblood forming tissue into irradiated mice, would save theanimal's life and preserve or restore antibody production.Investigations in many laboratories, including his own,have extended these findings and have established thatthe mechanism of recovery of these irradiated animals isrepopulation of the host by the donor tissue.Dr. Jacobson and others have shown that the inci- "I love the University of Chicago"-L. O. J.dence of late "homologous disease" and death in thesechimeras can be remarkably reduced by using embryonictissue as the donor material. Although these findingshave already been successfully applied to the practicalproblem of transplantation in man, they also have farreaching fundamental importance in immunology and related fields, especially when coupled with the work ofMedawar.With two medical students, Louis Plzak ('58) and Walter Fried (,58), Dr. Jacobson devised sensitive methodsof assay of erythropoietin, the hormone that regulates redcell formation (starved rat, hypertransfused mouse, andhypophysectomized rat). These assay procedures werein themselves unique contributions to the understandingof erythropoiesis.In 1957, Dr. Jacobson showed that after bilateral nephrectomy animals were unable to increase production oferythropoietin in response to the stimulus of blood loss orcobaltous chloride, and he postulated that one of the sitesof production of the hormone erythropoietin was in thekidney.During the administration of Leon Jacobson as Deanthe Faculty of the Division has been doubled; the size ofthe classes in the School of Medicine increased; many ofthe ancient laboratories have been renovated, and theendowment of the Division expanded vastly.The administration of Leon Jacobson will be outstanding as a period of construction of health facilities whichinclude the Ben May Laboratory for Cancer Research;Cummings Life Science Center; and The Surgery-BrainResearch Center.Leon Jacobson has received many honors: D.Sc. (hon)North Dakota State University, 1966; D.Sc. (hon)Acadia University, 1972; de ViJliers Prize of TheLeukemia Society, 1956; Borden Award in the MedicalSciences, Association of American Medical Colleges,1962; Degree of Master Physician; Phillips Award,American College of Physicians, 1975.Our Leader leads by activity rather than languagealone. He sets standards of excellence which we emulatebut do not attain, patterns of virtue in life, in work. LeonOrris Jacobson represents the redemption of America inthe Age of the Shoddy.Charles B. HugginsThere is an old aphorism to the effect that the love ofmoney and the love of learning rarely meet. This mayapply to ordinary persons but not to deans of medicalschools .. They know all too well that the love of learningcannot be fully indulged unless someone with a love ofmoney provides it.I have rarely participated in Jake's activities intendedto foster love of learning in the Division of the BiologicalSciences. However, we have often ridden the moneyraising circuit together. Potential donors can be shy andskittish, but they relax in Jake's company. He is easygoing and forthright in manner; himself convinced-andtherefore convincing-that the University can make thebest possible use of a gift of money. He has even gottensmall contributions from me.Upon his retirement, we should thank him not only forthe careful eye he has kept on the academic and clinicalactivities of the division but also for his success in obtaining much of the financial support which undergirds them.George W. BeadleMedicine on the MidwayThe University of ChicagoThe Medical Alumni AssociationThe Pritzker School of Medicine1025 East 57th StreetChicago, Illinois 60637 NON-PROFIT ORG.U.S. POST AGEPAIDPERMIT NO. 9666CHICAGO. ILL.•Address corrections requestedreturned postage guaranteed