�Medicine on the Midwa�9 //Bulletin of the Medical Alumni Association The UniversityDivision of the Biological Sciences and The Pritzker School aI.j.T.�.JvCover: Dr. Chung-Yuan Lin gives an anaesthetic to alittle girl before she undergoes heart surgery. An Assistant Professor of Anesthesia, Dr. Lin is an importantmember of the surgery team. The story of the team'swork starts on page 6 of this issue. The cardiologists,surgeons and other members of the medical team will belocated in the new Surgery-Brain Research Pavilion atthe University of Chicago as soon as the building is completed. For further details on the planned construction,turn to page 4.Medicine on the MidwayVolume 29, No. I Spring 1974Bulletin of the Medical Alumni Association ofThe University of Chicago Division of the BiologicalSciences and The Pritzker School of Medicine.Copyright 1974 by the Medical Alumni AssociationThe University of ChicagoEditor: Nancy SelkContributing Editor: James S. SweetPhotographers: Mel Oster, Diane Kuta, MikeShields, John Vail, Wayne SorceMedical Alumni AssociationPresident: Otto H. Tripple (46)President-Elect: Henry P. Russe (57)Vice-President: Asher J. Finkel (48)Secretary: Francis H. Straus II (57)Executive Secretary: Katherine T. WolcottCouncil MembersJoseph Baron (62)Sumner Craft (55)Lauren Pachman (61)Edward Paloyan (56)Donald Rowley (50)Joseph Skom (52) ContentsSurgery-Brain Research Pavilion Groundbreaking 4Open Heart Surgery 6And the Beat Goes On 6Second Medical Alumni Day 10Senior Scientific Session 15Internship and Residency Matching 22A New Thrust in Biology 24Diabetes-Endocrinology Center 25Seminar/Cruise to Greece and Russia 28Letters 29News Briefs 29In Memoriam 35Departmental News 36Alumni News 423� �� �r.-:::-"-An overview of part of the medical complex and the site of the SurgeryBrain Research Pavilion.An architectural rendering of the proposed building.Dr. Gerald Laros, Professor in the Department of Surgery and Chairman ofthe Orthopedics Section, (Center), at the reception.4 Surgery-Brain Research"This is a momentous but awesome occasion," University of Chicago President Edward Levi told a crowd of400 at the groundbreaking ceremonies for the SurgeryBrain Research Pavilion, May 30. "This will be thelargest and the most expensive single building on thiscampus. Its construction represents a long-standingcommitment of the University and the Brain ResearchFoundation. "The $21 million, six story structure, to be located onthe south east corner of 58th and Ellis, will connect Billings Hospital and Abbott Memorial Hall. It will housepatient care areas, operating suites, laboratories and administrative quarters. The first three floors will be devoted to brain research and will have a 26-bed neurosurgical patient care unit. The top floors will be the surgicalunit, containing 14 operating rooms and their supportfacilities, offices and research laboratories of the Department of Surgery.In his remarks, Dr. Leon O. Jacobson, Joseph Regenstein Professor and Dean of the Division of Biological Sciences and the Pritzker School of Medicine, said,"Only by understanding how the brain works can wedeal with its disorders. As the techniques and equipmenthave become more sophisticated, it has become increas-Dean Jacobson "breaks ground" for the Pavilion.Pavilion Groundbreakingingly difficult to accommodate the research in the existing facilities."The Clarence C. Reed Surgery Center will offer newbeds for patients suffering from highly complex nervoussystem disorders. "But most important," designers say,"it will bring many of the researchers together in onefacility, making possible a close collaboration betweenresearch scientists and practicing clinicians."Other speakers at the ceremony included William E.Fay, Chairman, Brain Research Foundation and Dr.David B. Skinner, Dallas B. Phemister Professor andChairman of the Department of Surgery. Dr. Skinnerread a statement by Dr. Clarence C. Reed ('24) who wasunable to attend. Dr. Reed, who has donated to otherUniversity of Chicago fund raising efforts in the past, haspledged a sizable endowment to the Surgery-Brain Research Institute.Despite threatening skies, the "shovel brigade," ofDr. John Mullan, John Harper Seely Professor, Head ofNeurosurgery and Surgery-Brain Institute Director; Dr.Skinner; Edward Levi and Mr. Fay, turned the firstspade of dirt at the construction site. University TrusteePhilip D. Block officiated. A cocktail reception followedthe ceremony. Trustee Block is master of ceremonies for the event.The "shovel brigade" included, from left, President Levi, Dr. Mullan, Dr. Skinner and Mr. Fay.5Open Heart SurgeryA Study in SkillJames StaceyMost of us are drowsily beginning our day at 7:30 in themorning, but at that hour on the sixth floor of theUniversity's Billings Hospital an alert team of doctorsand technicians assemble in the cardiac surgery operatingroom. The team this morning prepares to correct congenital heart defects of Stephanie Pearson, a four-yearold youngster whose problems include obstruction toblood flow to the lungs and a large hole between the twopumping chambers of the heart, creating a severe lack ofoxygen in the blood.Shortly after birth, Stephanie's condition was temporarily improved by when surgeons rerouted anartery from her arm to her lungs to increase the bloodflowing to the lungs. At that time, Stephanie was tooAnd The Beat Goes On ...The secret of successful heart surgery is team work, saysDr. Robert Replogle, chomping his stogie.The head of Cardiac Surgery at The University ofChicago Hospitals and Clinics is referring to those at theSilvain and Arma Wyler Children's Hospital who areresponsible for the treatment of youngsters with heartdefects. This includes cardiologists Dr. Otto Thilenius,Dr. Rene Arcilla and volunteer social worker EthelGoldsmith .. Each member provides the group with hisspecial expertise. But the team meets regularly to reviewthe needs of each patient and to map out the best courseof action.Five-year-old Alfredo Junsay, for example, came tothe hospital from the Phillipines. The doctors in Manilarecognized that the child had a heart defect at birth butdecided to wait until he was older to correct it. Thissummer, his physician referred him to Dr. Arcilla. "Thisis not the first time Dr. Calleja has recommended theUniversity to one of his patients," the cardiologist says."He has visited our facilities a number of times and waspleased with what we are doing here."Alfredo's family also felt his disorder could be "bettertaken care of at the Chicago hospital than it could in theirown country," so they sent him to the States with hisgrandparents.After being stranded without funds enroute, the familyfinally arrived at the children's hospital, where the firststep was to make a precise diagnosis by cardiaccatheterization. The two-and-a-half hour procedure wasperformed by Dr. Thilenius. The technique allows the6 small to withstand the rigors of open heart surgery. Nowshe is ready for complete corrections. The obstructionwill be removed and the hole between the two pumpingchambers will be patched. It will be a long operation.By 8 a.m., Stephanie is anesthetized and preliminarysteps have been taken. Her pulse, blood pressure andheart beat will be measured by electronic monitoringdevices, and the pressure in the great veins is measuredcontinually to provide information on the adequacy ofcardiac output.By 8:40, the preliminary steps are complete and themain surgery is about to begin. Clustered around theoperating table are two technicians who run the heartlung machine, two nurses to help at the table, two additional nurses to provide additional equipment, if required, and two anesthesiologists; the surgeon and twosurgical assistants approach the table. They place steriletowels around Stephanie's chest to outline the area forthe operation. Soon larger towels completely shroud herbody and all that remains in view is the small chest area.The operation begins. The breast bone is severed andthe chest opened. The heart is much larger than onewould suspect, almost as large as a fist. The connectingdoctor to "look inside" without opening the body. Along, thin tube is inserted through the blood vessels intothe heart and special x-rays and blood samples can betaken. With the use of sophisticated monitoring equipment, the cardiologist can examine the heart indirectlyand localize the cause of malfunction. The child is notanesthesized and can, if necessary, exercise during theprocedure. The diagnostic methods identified a hole inthe wall between the receiving chambers of Alfredo'sheart. The team recommended that open heart surgery bedone.From the time of the family's arrival to its departure,Mrs. Goldsmith worked closely with the Junsays. Shehad to overcome the obstacles of a slight language barrierand the trauma of the journey in order to go about reassuring the grandparents. Fortunately, they already knewthat an operation was likely, and this reduced the uncertainty for them."It is always difficult for families to bring in a seemingly healthy child and have to watch him go through allthe events of surgery," Mrs. Goldsmith said. "But it iseven more distressing when young parents are faced witha risky heart operation in a tiny infant, sometimes withina few days after birth; often while the mother is still in thehospital. But there is a positive side to this. We havebetter diagnostic tools and the problems can be sortedout and resolved much earlier and with greater likelihoodof success than ever before."During the course of the hospitalization, the socialworker played a key role, keeping the grandparents informed about what was happening and carefully explaining all that was strange to the family. "We are allsensitive to the emotional strain on the parents and thepatients, and all of us try our best to make the hospitali-arteries and veins to the heart are delicate, and they mustbe attached to the heart-lung machine with care. Themachine is a piece of equipment that will supportStephanie's body while the heart is stopped and the defects corrected.The technicians who run the machine wait while preparations are made. There are over a dozen sutures,clamps and scissors carefully placed about the operatingfield. Before the by-pass can be started, all the body functions must be finally checked, and it is almost noon before the heart-lung machine can be wheeled close to thetable.After the by-pass is started, Stephanie's circulationwill be controlled and her blood oxygenated by a mechanical device for the next 40 minutes. Her heart can now beopened and repair can begin. Removing the blockage isthe first step. For some unknown reason, additional heartmuscle tissue accumulated in her heart, blocking bloodflow to the pulmonary artery and the surgeon carefullyremoves this tissue.Now he begins work, placing a patch of dacron material to close the hole between the pumping chambers. Thepatch looks something like a piece of gauze, especiallywhen circled by lines of thread. At last the patch is pulled tight and one-by-one the threads are cut just above theknots.It is almost 1 p.m. The surgical team has been workingfor five hours. Betraying no sign of fatigue, the surgeonand his group complete the repair and starts the heartagain by initiating coronary blood flow. The heart beginsto beat slowly, then with increasing dispatch, while themonitoring equipment is checked continuously. Whenthose operating are satisfied that everything is workingproperly and the repair is satisfactory, the incision isclosed.The operation is over. It is almost 2 p.m., and the surgeon leaves the surgical suite, resting for a momentin the doctor's lounge. After a few sips of coffee, thesurgeon begins dictation into a voice recording machine.Each step of the operation is detailed. Every fact of thecase is brought forward and when he is finished, he leansback and reflects for a moment on the many meanings ofthis operation.It brings health to a young girl. Now Stephanie hasa chance to grow normally. She won't be frail anddelicate. She'll be able to run and play like other children. Her heart will be firm and strong.Anxious parents wait outside while their child is in the operating room. Allmembers of the team keep close contact with the patients and theirfamilies throughout hospitalization. zation as pleasant as possible," says Dr. Replogle."However, Mrs. Goldsmith carries the heaviest burdenof determining the individual patient's needs and alertingthe medical staff to any that require extra attention."The University of Chicago medical complex has longbeen recognized for excellence in the fields of pediatriccardiology and cardiac surgery. Its million dollarcatheterization laboratory in the Silvain and Arma WylerChildren's Hospital and its pediatric intensive care unitare "outstanding," according to team members.Each word telegraphs their enthusiasm for cardiacsurgery and its many challenges. Discussing some of themore interesting medical problems the team has dealtwith, Dr. Replogle talks at length about Alfredo, oneyear-old Oliver Clark and four-year-old Stephanie Pearson, all of whom had holes in their hearts, had satisfactory repairs and are now enjoying normal lives. Dr. Replogle spoke of a score of other small patients to indicatethe scope of cases and of treatment at the South Sidefacilities.Of particular interest is the disorder of a two-monthold baby who came to the hospital with a single bloodvessel leading from the heart, rather than the normal twovessels (one to the body and one to carry blood to thelungs for oxygen). The infant had a new artery, completewith valve, implanted. The technique used to treat thischild (and many others) is "profound hypothermia" andcirculatory arrest." His body was packed in ice bags andsuspended in a tank of cold water. After the temperatureand heart beat dropped to a low level, a potassium solution was injected into the heart, stopping its action for 61minutes. Upon completion of the treatment, warm bloodwas pumped through the body restoring the regular beat.The entire procedure took about six hours. Post-7operatively, the baby is doing beautifully. Dr. Reploglesays, "The time it takes to make all the preparations isgreater than the time needed for the operative procedureitself. "While in the temporary cold state, all of the circulationto the body is completely stopped. Because of the lowtemperature, the energy required for the cells to maintainthemselves drops sharply and the brain's need for criticaloxygen dwindles to almost nothing."Ordinarily a child goes home following heart surgeryin about 10 days. Though the procedures have becomemore complicated, the risks have gone down. This is dueto better and earlier diagnosis, more experience and better techniques and equipment," he says.First brought to light in 1951, the "icebox" methodwas little used until the late 1960s when it was revived byJapanese surgeons. More than 40 such operations havebeen done at The University of Chicago since 1971 andphysicians here have helped other centers in the UnitedStates develop similar programs.Heart surgeons have, in the past, tended to favor useof the heart-lung machine. But it requires the presence ofseveral tubes which severely restrict the tiny work areain an infant's heart. Hypothermia on the other hand, allows the doctor to work in a nearly bloodless field, whilethe heart is soft and there are fewer pieces of hardwareinvolved.Prior to the use of hypothermia, a child had to waituntil he was a year or more before surgeons would operate. Now, doctors here feel the work can be done as earlyas necessary. "While surgery is most difficult before theage of six months, there can be no hard and fast rule.When possible, we try to wait until the child is two orthree years old but surgery is sometimes required withinthe first day of life. The weight of the baby is more important than the age. He should be at least two or threepounds," Dr. Thilenius says.At the current birthrate, an estimated 28,000 childrenare born annually with a heart defect. Nearly 1,000 children are seen during the year at the University outpatient cardiac clinic. An estimated 80 percent of thosereferred for evaluation because of a heart murmur, haveinnocent problems, Dr. Arcilla says. But many of thesecannot be diagnosed without equipment which can clearup all reasonable doubt. This means that the cardiologistmust carry out the necessary tests and the social workermust reassure the parents that their fears are exaggerated.The path to be followed is not always clear cut. Eachproblem has to be evaluated by the group, and the decision based on many factors. In some instances, for example, it may be influenced by the non-medical needs ofthe family-such as the availability of babysitters for theother children or vacation schedule of the patient.There are other instances where the medical conditions dictate immediate treatment. If, for example, toomuch blood is going to the lungs, harmful changes mightoccur rapidly. Holes within the heart, on the other hand,often tend to get smaller as the child gets older and waiting might be more appropriate, Dr. Arcilla says.There are only three possible decisions: surgery, med-8 ical treatment or "watching" and each of these has itsproper role. Abnormaldevelopment of the heart muscle,for example, can only be treated by medical intervention,he says, until heart transplants become more generallyapplicable.Temporizing by surgical methods, or "palliation" isappropriate on occasion, although this is less commonlyused now that improved techniques have made surgicalcorrection feasible in most instances. These palliativemeasures can be either major or minor adjustments thatwill tide the patient over until corrective surgery is indicated. Such ventures do, however, have limitationswhich the surgeons must consider before deciding whatsteps to take.On a few occasions, the doctors agree that nothing canbe done to help the patient and they have to give the sadnews to concerned parents.The team is by no means limited to the few doctorsalready mentioned. Hypothermia techniques werelargely the result of the work of Dr. C. Y. Lin, AssistantProfessor of Anesthesia. He and Dr. Robert Paulissian,Associate Professor of Anesthesia are "outstanding"anesthesiologists, says Dr. Replogle. Other key doctorswho work in Cardiology and Surgery are Dr. Domingode la Fuente, veteran pediatric cardiologist Dr. DonaldCassels and senior cardiac surgeon Dr. ConstantineAnagnostopoulos. Surgical residents also play an important role in the department, making significant contributions to the treatment of the patients.The team's coordinated efforts and basic concern forOr. Thilenius prepares to insert a tube during the cardiac catheterizationprocedure for Alfredo Junsay.Dr. Replogle operates on an infant. The work is exacting and demanding.the individual rank high among the key elements responsible for the unit's smooth operation. "Every patient is aprivate patient as far as we're concerned," Dr. Reploglesays. "We are available 24 hours a day, 7 days eachweek, 12 months a year."While one foot is in the present, the other is edgingtoward the future. Increasingly, the Cardiac SurgeryService is directing its thrust to treating adult patients,including surgery to replace heart valves or grafts tobypass obstructed coronary arteries. Patients in their 70sand 80s have successfully undergone open heart surgery.Until the early 1960s, the medical community as a wholegave little serious thought to the idea of replacing wornout heart machinery in older people. But with the advance of new techniques, this concept of medical care isreceiving greater consideration and application. TheUniversity has recently completed a modern cardiaccatheterization laboratory for adults.Work is also being done with cardiac assistance devices which aid the heart during circumstances offailure, as might occur after a heart attack. Still in itsincubation period, a pulsatile heart pump system andmembrane oxygenator are also being developed. Theyshould, according to hospitals officials, improve the safety and effectiveness of heart-lung by-pass proceduresand resuscitations. In the future, Dr. Replogle sees useof artificial hearts and lungs.Doctors are now taking the amniotic fluid (in which thefetus grows) to test it for certain known abnormalities."About 3 to 5 percent of the children with heart diseasehave some specific genetic abnormality even though theparents are usually normal," Dr. Thilenius says. "Bytesting the fluid from the mother's uterus, we may be ableto determine if certain chromosomal abnormalities arepresent and thus be in a position to predict the conditionof the child before it is born. Eventually when diagnosticmethods are suitable for the identification of heart lesionsin the fetus, we might even be able to treat the child inutero," Dr. Arcilla predicts. The recent arrival of Dr.John Burrington, as Chief of Pediatric Surgery, gives impetuous to this future development, since Dr. Burringtonhas done experimental surgery in fetal animals.Researchers already know that there is sex differencein the incidence of congenital heart disease but otherwise, the distribution is fairly even. They also know thatthere is some family tendency to the problem. If onechild has heart disease, the chances are somewhat increased that another might follow with the samedifficulty. But there is still little known about the causesof the birth defect, Dr. Replogle says. Team membershope to place a great deal of emphasis on finding outmore about the origins of defects.Research related to cardiac problems in the adult isgenerally focused on damage produced by obstruction ofthe coronary arteries by aetherosclerosis. Recentfindings suggest that damage to heart muscle that followsa heart attack may not always be irreversible. Universityof Chicago scientists have isolated human heart cells andinduced them to grow in the lab. The hope is that thiswork will lead to improved methods of protecting andpreserving heart tissue that otherwise would be irreversibly destroyed.After a six hour operation, the surgeon rests, his energy drained.9Second Medical Alumni DaySilence fell as medical students, faculty, friends andalumni listened attentively to the words of Hippocratesand Maimonides. With the resounding tones of the greatorators, Dr. Rory Childers, Associate Professor, Department of Medicine, presented the oathes to the newestmembers of the medical profession the 1974 graduatingclass of the Pritzker School of Medicine.For many, this was a high point of the activities planned for the second annual Medical Alumni Day, as thegraduates took their place on the alumni rolls. Forothers, the highlight was an awards presentation at whichthe older members of the association received theirkudoes. Both groups had the chance to feel that the daywas uniquely theirs.Scientific SessionsThe formal part of the program for June 13 began withsix lectures by former University of Chicago graduatesand faculty members who have gone on to unusually successful teaching and medical careers. Speakers and theirtopics for the sessions were:Richard Kekuni Blaisdell, M.D. (47), Professor ofMedicine, University of Hawaii "The Significanceof Platelet-Subendothelial Interaction"Roy R. Grinker, Sr., M.D. (21), Director of theInstitute for Psychosomatic Research and Training,Michael Reese Medical Center; Professor ofPsychiatry, The University of Chicago "What arethe Schizophrenias?"Aaron Kellner, M.D. (39), Director, The NewYork Blood Center, Clinical Professor of Pathology, Cornell University Medical College' 'The Regional Blood Center-A New Health Facility"Richard Langendorf, M. D., Senior AttendingPhysician, Department of Medicine, and SeniorInvestigator, Cardiovascular Institute, MichaelReese Medical Center; Clinical Professor of Dr. Kellner, left, receives his award from Dr. Dorfman.Medicine, The University of Chicago "Newer Aspects of Concealed Conduction of the Cardiac Impulse"Robert C. Stepto, M.D., Ph.D. (48), Professor andChairman, Department of Obstetrics and Gynecology, University of Health Sciences, The ChicagoMedical School/Mount Sinai Hospital MedicalCenter "The Significance of the Abnormal PapSmear"Nancy E. Warner, M.D. (49), Professor andChairman, Department of Pathology, University ofSouthern California "Malignant and PremalignantLesions of the Mammary Gland"At the Quandrangle Club luncheon following the lectures, all presenters were given the Distinguished Service Awards for their contributions to the field ofmedicine. Dr. Kellner was handed the certificate ofhonor by a former classmate who has remained at theUniversity as a teacher-Dr. Albert Dorfman (44). Dr.Werner Kirsten gave the award to his former teacher andcolleague, Dr. Warner-and received a kiss of gratitudefor his short introductory speech. Others giving the honors were Drs. Clifford Gurney (51), Daniel X. Freedman, Alvin Tarlov (56), and Robert Wissler (48).Alumni who came to see their sons graduate were, from left Dr. Cooperman and his son Daniel; Dr. Kahn and son James; Dr.Taylor and son Stewart; Dr. Wasserman and son Paul and Dr. Graff and son Marc. l70Professional Achievement AwardAlumni Dr. Charles Dunham, (34 Rush- U of C) andhis wife, Dr. Lucia Dunham, (36), were given the Professional Achievement Award at the University-widealumni day June 8. Charles Dunham, formerly Directorof the Division of Biology and Medicine of the UnitedStates Atomic Energy Commission, is an authority onradiation biology and the effects of atomic radiation onpeople. He was on the faculty of The University ofChicago Medical School until 1949. Lucia Dunham is aMedical Officer of the Laboratory of Pathology at theDr. and Mrs. Langendorf talk to Dr. Jar! Dyrud, Professor of Psychiatry, atthe alumni day luncheon.National Cancer Institute, conducting research in thefield of geographic pathology. She was first employed asa research assistant in Pathology at The University ofChicago and was associated with Dr. Paul E. Steinerwhen he was carrying out important studies on themechanisms of chemical carcinogenesis. She has alsobeen involved in studies of bladder and uterine cancer.Fifty Year ReunionIt was also a moment of glory for the class of 1924.Sixteen graduates came from across the country to receive special certificates for their 50 years of service. Dr.Eloise Parsons Baker prepared a fact sheet showingwhere her classmates are today. While 17 are retired, 48are still active. One of the women at the reunion hadmade a house call just before she got on the plane tocome to Chicago. Though the day had begun at 8 a.m.with a breakfast, the older alumni were still showing nosigns of fatigue as they prepared for the second round ofevents. After the luncheon, they stopped long enough tolook at old class pictures and discuss the latest gossipbefore going off to tour the campus. Some, admittedly,did sneak away for a rest but then they showed up revitalized for the last event which ran on for several hours.Other classes to hold alumni reunions were:1939-Chairman, Leon Jacobson; 1949-Janet Rowley;1954-Dorothy Windhorst. Dr. Step to receives his certificate of honor from Dr. Wissler.Seniors HonoredAs the day was reserved for the returning graduates,the reunion banquet at the Furniture Mart was devotedto the class of 1974. Graduates added a humorous touchto the evening with their renditions of "Medical Music"from the senior skit. And pot shots were taken in goodnature at the medical profession during a dramatic production of Hippocrates and Hypocrites: Doctors in theTheater by Nick Rudall, Director of The University ofChicago Theater, and his wife Diane. A double violinconcerto was performed by residents Louise and CharlesKawada and Pianist Eduardo Kneler. While the entertainment was perhaps the most relaxed part of the evening, it was by no means the central part. The undisputedhighlights of the program were the presentation of theoathes and the award ceremonies. Students honored include:Seniors elected to Beta of lllinois Chapter of AlphaDr. Roy R. Grinker, left, talks to Dean and Mrs. Jacobson.11Omega Alpha for excellence in the work of the school:Ira BergmanSteven Allen BlauThomas G. BrottAmy Hamburg BrownKathleen H. FlohrPamela Maria GallagherRuth GrantEarl Webb Henry Susan HochBeverley L. KetelTheodore Zane Polley, Jr.J ames Andrew SchulakHoward Ray SchwartzAnna-Elisabeth SommerfeltAnne Bouise WardThe Joseph A. Capps Award, to a senior medical student for proficiency in clinical medicine,Anne BouiseWard.The Franklin McLean Medical Student ResearchAward, to a senior who has performed the mostmeritorious research, Frank Charles Seifert.The John Van Prohaska Award, for outstanding potential in teaching, research, and clinical medicine, KathleenH. Flohr.The Medical Alumni Prizes, to seniors for the best oralpresentation of research done during their years in medical school, Jonathan Matthews Rubin, John Francis Gallagher, Pamela Maria Gallagher.The Mary Roberts Scott Memorial Prize, to a womanmedical student for academic excellence, Kathleen H.Flohr. Dr. Coe beams as he goes to the head table to receive the McClintockaward.The Nels M. Strandjord Memorial Award, to a seniormedical student for outstanding performance in the general field of radiology, Peter C. Ree.The Upjohn Award in Medicine, to a senior for outstanding achievement during four years in medicalschool, Thomas G. Brott.Graduated with Honors: Kathleen Flohr, TheodorePolley, Lawrence Pottenger, Anne Ward, WilliamWason.Lawrence Aggerbeck received the 1974 Honored Student Award of the American Oil Chemist's Society inMexico City this spring for his study of the" AbnormalLipoproteins in a B- Lipoproteinemia," He also obtainedOfficers of the Medical Alumni Association for 1974 are: Donald A. Rowley, counci/lor; Otto H. Trippel, president; Francis H.Strauss II, secretary; Henry P. Russe, president-elect and Asher V. Finkel, vice-president. Sumner C. Kraft, counci/lor is not inthe photograph.12a fellowship from the French Ministry to do postgraduate research this year at the National Center forScientific Research in France.McClintock and Jenkins AwardsThen the tables were turned and the students paid tribute to their favorite professor and favorite member of thehouse staff. Dr. Fredric Coe, (61), received the McClintock A ward for outstanding teaching from the Class of1974. The honor is one of the highest faculty memberscan attain. Dr. Coe is affiliated with Michael Reese Hospital and Medical Center where he is Director of theRenal Division. The professor, who devised the diagnosis and treatment of hypertension by computer, is incharge of the first Hypertension Registry in the UnitedStates. Dr. Coe did both undergraduate (B.A., B.S.) andgraduate (M.D.) work at The University of Chicago. HeDr. Warner is shown with Dr. H. Trippel.has written more than 35 papers on the subject of renalcare.The Hilger Perry Jenkins Award, for excellence in performance of academic and patient-oriented service, wentto Dr. Richard Driscoll, a second year resident in theDepartment of Medicine. Dr. Driscoll did his internshipat the University of Chicago from 1972 to 1973. He received him M.D. degree from the University of Pennsylvania.Gold KeysUniversity of Chicago Professors Dr. Frank Newell,Dr. Samuel Spector and Dr. Charles Huggins, had thehonor of presenting the Association's Gold Key toformer faculty members Joseph P. Evans, Intern, (30),F. Howell Wright, Department of Pediatrics (46-73) andfaculty member George W. Beadle, William WratherDistinguished Service Professor and President Emeritusof the University. Evans served on the staff as Professorof Surgery (54-70) and became Professor Emeritus in 70.He is currently a Latin American Liaison Representativefor the American College of Surgeons. Dr. Wright was Dr. Blaisdell, left, is talking with Dr. Joseph Evans, who received a GoldKey at the banquet.Chairman and Professor at the medical school from 51 to60. He became Professor Emeritus in 73. Dr. Huggins'presentation of the Gold Key to Mr. Beadle came as asurprise at the dinner. Both men are Nobel Laureates.Record AttendanceThe dinner was attended by a record 419, withgraduate Rosalba Gomez contributing the largest singlegroup towards that figure. She brought 27 relatives andfriends. Five members of the senior class shared theirgraduations with their fathers, who had received theirdegrees here in the 30's and 40's. Dr. Norman Cooperman, B.S. (31), M.D. (32), was here to see his son Danielgraduate. Dr. Norman Graff, B.S. (47), M.D. (48) to seeMarc David; Dr. Alfred Kahn, S.B. (40), Ph.D. (43),M.D. (44), to see his son James; Dr. Stewart Taylor Sr.,S.B. (43), M.D. (45), to see his son Stewart and Dr.Franz Wassermann, S.B. (41), M.D. (43), to see his son'Paul.As the last act of the evening, the new slate of AlumniAssociation officers was introduced. And as his first actas President, Dr. Otto Tripple declared the meeting adjourned, a welcome announcement as the hour moved to10:30.Dr, Dobson, past president of the Alumni Association.13The class of '24 met for its 50th anniversary. Those who came to the reunion were: (Back row from left) Eugene Ziskind, FinisCooper and Mila Pierce. (Front row from left) Mary Gilliland, Charlotte McCarthy, Eloise Parsons Baker, Lucia Tower, LouisRiver, M. Alice Phillips, C. Helge M. Janson, Jack Allan Weiss, Arkell M. Vaughn, Fred O. E. Eggert and Howard Wakefield. JohnF. Pick and William Shapiro were there but are not in the picture.Members of the Class of 7954 at their reunion were (standing) Dr. and Mrs. David Rosenberg, Dr. and Mrs. John Kasik, DorothyWindhurst, Gordon Siegel, (sitting) Hugh Davis, Dr. and Mrs. Charles Shapiro, Dr. and Mrs. Edwin Stickney, Lois Scheimann.Those who came to the class of '49 reunion were: H. William Barden Werper, Dr. a·nd Mrs. Gerald Miller, Dr. Janet Rowley, Dr.Donald Rowley, Dr. and Mrs. Robert Slayton, Nancy Warner, Sherwood Miller, Dr. Mary Carroll, Mr. Carroll, Dr. and Mrs.Charles Bacon, Eugene Miller, Dr. and Mrs. Norman Graff and Dr. and Mrs. Robert Wissler.14Sen ior Scientific SessionFourteen senior medical students of the University ofChicago Pritzker School of Medicine Class of 1974 presented abstracts of their research at the 28th AnnualSenior Scientific Session, Wednesday, May 15, in theFrank Billings Auditorium. Following each paper, thechosen discussant made brief comments, giving additional information on the subject or raising questions.Each student was sponsored by a faculty member.The day-long program was divided into three areas ofinterest, with a faculty member presiding at each session.The first general topic was surgery, chaired by Dr. DavidB. Skinner, Dallas B. Phemister Professor and Chairmanof the Department of Surgery; the second was immunology, chaired by Dr. Donald F. Steiner, (56), A.N. Pritzker Professor and Chairman of the Department ofBiochemistry; the third, assorted topics, chaired by Dr.Werner H. Kirsten, Chairman of the Department ofPathology, Professor of Pediatrics and member of theCommittee on Genetics. Serving on the ArrangementsCommittee were Dr. Francis H. Straus II, Chairman,(57); Dr. William Gill; William Martin, Ph.D. and Dr.Otto G. Thilenius.Jonathan Rubin was awarded first prize for his outstanding presentation. A second prize was given toPamela and John Gallagher. All three received theirhonors at the Medical Alumni Banquet June 13. Dr.Rubin will be doing his internship in radiology at theUniversity of Chicago, Pritzker School of Medicine.Drs. Gallagher will intern at New York Hospital of Cornell Medical College-he in general surgery, she in plastic surgery. Frank C. Seifert won the Franklin McLeanMedical Student Research award for the most meritorious research. Lawrence Aggerbeck received the 1974Honored Student Award of the American Oil Chemist'sSociety for his research and a fellowship from the FrenchMinistry to do post-graduate work at the National Centerfor Scientific Research.A Study of the Abnormal Lipoproteins InAbetalipoproteinemia (ABL)By Lawrence P. Aggerbeck, Ph.D.Sponsor: Dr. Angelo M. ScanuDiscussant: Dr. Godfrey GetzAbetalipoproteinemia (ABL) is a rare inherited disordercharacterized by: 1) ataxic neuropathic disease 2) malabsorption of fat 3) pigmentary degeneration of the retinaand 4) acanthocytosis.In terms of serum lipoproteins, the absence of lowdensity lipoproteins (LDL) has been recognized in previous reports. Based on preliminary data indicating furtherlipoprotein abnormalities, a systematic analysis was carried out on all the lipoproteins and their apoproteins fromthe plasma of five ABL patients obtained by repeatedplasmaphoresis. In accord with previous reports, all the Lawrence Aggerbeck Oliver Cameronpatients lacked both normal LDL and LDL apoproteinas assessed by immunochemical and electrophoreticmethods. Abnormal particles were found having theftotational properties of LDL, the polypeptide makeup ofHDL, spectral and morphologic characteristics ofneither LDL nor HDL and a low content of cholesterolesters. The HDL were also abnormal in having a peculiarpolypeptide distribution comprising additional components usually not seen in normal controls. HDL wasmarkedly decreased and had an altered proportion of thesubclasses HDL2 and HDL3.It is concluded that ABL is a disorder affecting allserum lipoprotein classes thus indicating that the termabetalipoproteinemia may no longer be applicable to describe lipoprotein abnormalities in this disease state.Therelationship between observed lipoprotein abnormalitiesand clinical manifestations cannot be established by thepresent study.Stimulus Properties of Drugs: LSD as SD andUCSBy Oliver Cameron, Ph.D.Sponsor: Dr. James B. AppelDiscussant: Lewis Seiden, Ph.D.As psychobiologically defined, a stimulus is any environmental event which can control an organism's be-David Crnic Kenneth Gass15havior. Classically, events external to theorganism-e.g., lights, buzzers, odors-have been employed in behavioral studies. But organismic events suchas heart rate and muscle tension can also be used. Drugs,administered externally but functioning internally, can bepowerful stimuli controlling behavior. This research concerned the use, in rats performing an operant task, ofd-LSD in several stimulus capacities, as well as comparisons to, and modification by, other pharmacologicalagents.In the first series of studies, d-LSD was utilized as anunconditioned stimulus in a Pavlovian conditioning procedure. The results showed: (1) 0.20 mg/kg functionedstrongly; (2) 0.13 mg/kg was not effective; (3) 4.0 mg/kgof chlorpromazine and 2.0 mg/kg of psilocybin also produced conditioning, while neither 50 mg/kg of methyl atropine nitrate nor 25 mg/kg of pentobarbital were effective; (4) 0.20 mg/kg of LSD as well as 4.0 mg/kg of amphetamine produced conditioning even with a lowbaseline behavior rate; and (5) stimulus generalization ofthe conditioned LSD effect occurred.In a second set of experiments, d-LSD was employedas a discriminative stimulus in an instrumental behaviorparadigm. The findings were: (1) 0.02-0.04 mg/kg wasthe "threshold" dose for discrimination from non-drug,while 0.08 mg/kg was clearly discriminable; (2) 0.08mg/kg was also discriminable from amphetamine; (3)other "hallucinogenic" drugs produced states more similar to d-LSD than non-drug, while "non-hallucinogenic"agents elicited responses like non-drug; and (4) PCP A, aselective serotonin depletor, increased subjects' abilityto discriminate d-LSD from non-drug, but two manipulations intended to "desensitize" the animals (pretreatment with chlorpromazine or LSD itself in an acute tolerance regimen) had no effect.The Effect of Mannitol and Glucagon on theMicrocirculation of Revascularized IschemicBowelBy David M. CrnicSponsor: Dr. David B. SkinnerDiscussant: Dr. Robert ReplogleComplete temporary vascular occlusion of a canine smallbowel segment for 6 to 10 hours causes a variable resultfollowing revascularization-infarction or stricture insome and complete recovery in others. The presence ofhyperemia in the revascularized bowel segment compared to adjacent normal bowel predicts viability. Thisstudy examines whether mannitol or glucagon favorablyalters the outcome of restoring flow to ischemic bowel byincreasing perfusion during recovery.The blood supply to 15 ern segments of ileum wascompletely interrupted for 6 to 10 hours in 24 mongreldogs. After restoration of flow perfusion of the revascularized ischemic segment relative to adjacent normalbowel was measured by injection of 99M Technetiumlabelled albumin microspheres into the descendingthoracic aorta. Seven animals received mannitol (2576 grams IV over 5 minutes), 10 dogs received glucagon (50ug/kg IV over 1 minute, every 20 minutes for 1 hour) andthe remaining 7 dogs received no drug. A second dose ofTechnetium labelled microspheres was given after 60 minutes. Radioactivity was again counted over the ischemicand adjacent normal bowel and results were computed.After abdominal closure, the animals were allowed torecover without any supportive therapy. Autopsy wasperformed on all animals that died. Six weeks later, thesurvivors were sacrificed and their intestines examined.Results: Glucagon increased blood flow through normal bowel four-fold, but not through previously ischemicsegment. Mannitol improved flow through the microcirculation of underperfused bowel two-fold, but did notaffect normal bowel. If reactive hyperemia was presentafter re vascularization, the blood flow was unaffected byeither drug. Bowel viability and survival rate were identical in each of the three groups. All dogs that died had atleast one perforation in the ischemic segment at autopsy.We conclude that mannitol has a beneficial effect onthe flow to ischemic bowel but this is insufficient to alterbowel viability and survival in our preparation.John and Pamela GallagherCardiac Resuscitation with Mechanical Ventricular Assistance and Its Effect on CerebralCirculationBy Pamela and John GaUagherSponsor: Dr. Javad Hekmatpanahand Dr. David B. SkinnerDiscussant: Dr. John MuUanCerebral blood flow was studied in 12 cats and 8 monkeysduring cardiac arrest and resuscitation. The cardiac arrest was produced by application of electrical current of2to 8 volts internally. Resuscitation was accomplished byartificial respiration, maintenance of acid-base balance,and mechanical ventricular assistance. Central arterialand venous pressures, EEG, EKG and respirations weremonitored. Cerebral blood flow was studied by directobservation of the pial vessels under magnification andthrough Xenon washout.The animals were divided into two groups of 10 each.The first group was arrested for 7Y2 minutes; the secondgroup for 10 minutes. When cardiac arrest was initiated,the EEG became flat, the pupils dilated and the CVPbegan to rise within 15 to 30 seconds. The Xenon washout curve became flat and the pial blood flow ceasedduring the entire arrest period. Within 2 to 3 minutes thered cells sludged and within 5 to 10 minutes microembolideveloped.With initiation of resuscitation by MV A, mean arterialpressures usually ranged between 70 and 100 mm. Hg,and CVP began to fall. Xenon washout resumed and pialcirculation returned, but at a reduced rate. Microemboliwere flushed out of many of the capillaries and largervessels; some capillaries, however, remained occluded.In most cases, the pupils remained dilated and the EEGflat during the period on MV A. After one hour of MV A,the hearts were either in sinus rhythm or easilydefibrillated and maintained satisfactory blood pressureswithout vasopressors.The pial circulation during MV A was shown to besuperior to that seen with internal cardiac massage. Thedegree of improvement seen in pial circulation could becorrelated with the level of mean blood pressureachieved by MV A. It appears that a similar correlationcan be drawn for the length of survival of the animals;nevertheless, all animals died within three days after resuscitation. These results seem to indicate that the sustained maintenance of a normal arterial pressure viaMV A in the immediate post-arrest period might exert aprotective effect which allows recovery from cerebral ischemia of longer periods than have been previously observed.Isolation of Three DNA Polymerases fromBacillus subtilis: Their Enzymological andPhysiological CharacterizationBy Kenneth B. Gass, Ph.D.Sponsor: Nicholas R. Cozzarelli, Ph.D.Discussant: Samuel B. Weiss, Ph.D.Three DNA polymerases have been purified and characterized from Bacillus subtilis and the physiological role oftwo of them determined. The three enzymes catalyze thesame basic reaction but can be distinguished by theirresponse to various DNA templates, high salt, heat,sulfhydryl blocking reagents and antimicrobial drugs.DNA polymerases I and II, unlike the other knownbacterial and phage DNA polymerases, have no intrinsicnuclease activity. Certain Bacillus subtilis mutantsdeficient in excisional repair of DNA damaged by alkylation and ultraviolet light were found to have no detectable polymerase I, thus indicating a role for this enzyme inDNA repair. The triphosophate derivative of the potent antileukemic agent arabinofuranosylcytosine (ara-CTP)inhibits replicative DNA synthesis in Bacillus subtiliscells rendered permeable by toluene treatment. In vitropolymerases II and III, but not polymerase I, are inhibited by ara-CTP. The analogue is a competitive inhibitor of dCTP incorporation and, surprisingly, is itselfincorporated into DNA which slows subsequent chainelongation. The arylazopyrimidines specifically inhibitreplicative DNA synthesis in a wide variety of Grampositive bacteria. Polymerase III alone is inhibited invitro by these drugs and by a novel mechanism.Polymerase III is sequestered in a non-productive ternary complex of enzyme, drug and DN A in which theinhibitor forms a specific base-pair with the template.These results show that polymerase III is necessary forchromosomal replication.Marc Graff Edward LinnNa" -K+ -ATPase, Mg++ -ATPase andCa++ - ATPase Activities in Erythrocyte Ghostsof Psychotic PatientsBy Marc D. GraffSponsor: Dr. Herbert Y. MeltzerDiscussant: Dr. Lawrence FreedmanThe search for biochemical correlates of psychoses hasbeen focussed on biogenic amine metabolism. With therise of lithium therapy and a more sophisticated understanding of cell membranes and their associated enzymesof ion transport, a search for ionic abnormalities inpsychoses has also begun. The erythrocyte ghost membrane with its associated ion transportenz ymes=-Na" -K+ -ATPase, Mg++ -ATPase andCa'" -ATPase-may provide a suitable model for investigation of this area.Erythrocyte ghosts from eight psychotic patients andmatched controls were prepared. Total ATPase,Mg++-ATPase and Mg++-ATPase + Ca++-ATPaseactivities were assayed by measuring the amount of inorganic phosphate released during incubation of the ghostswith ATP and various promoters and inhibitors. Fromthis data, Na" -K+ -ATPase and Ca'" -ATPase activities were calculated. When paired samples were compared using Student's t-test, two-tailed, both17Peter ReeMg++-ATPase and Ca'" -ATPase activities in the patients were greater than those of the controls(0.10 > P > 0.05), implying real intra-pair differencesexist. No significant difference in N a+ - K+ - A TPase activities was found (0.95 > P > 0.90).These results provide a framework to explain previously described electrolyte abnormalities in somepsychotic patients. The elevation of ion transport enzyme activities, whether primary or secondary topathological alterations of cell membranes, in terms oftheir relation to biogenic amine transport and storage,may serve as a basis for ion transport models of psychoses.Studies on the Purification and Characterizationof Human LymphotoxinBy Edward S. LinnSponsor: Dr. Samuel RefetoffDiscussant: Dr. Ann LawrenceIt has been shown that, when stimulated, lymphocytescan be transformed into an active state. This has beendemonstrated, in vitro, by morphological, ultrastructural,and biosynthetic changes, and also by the release of various soluble mediators. One of these mediators, a solublecytotoxic factor or human lymphotoxin (HL T), previously shown to be released from lymphocytes under thestimulation of antigens or mitogens, has recently beenshown to be secreted spontaneously from establishedlymphoid cell lines (HLT-LCL). This paper deals withthe study of the purification, stability, and immunologicalcharacteristics of HLT-LCL.HLT-LCL was purified from supernatants of cell cultures using ammonium sulfate fractionation, gel filtration,ion exchange chromotography and polyacrylamide-gelelectrophoresis. At each purification step the HL T - LCLbioactivity was measured using an L-cell monolayercytotoxic assay. The final purification increased thespecific activity of the initial material 50 fold and wasslightly greater when the medium employed was devoidof fetal calf serum. Temperature and pH stability evalua-78 tions showed that HL T - LCL was stable at -20°C. forover 1 year, 4°C. for 3 weeks, and 37°C. for 1 week.HLT-LCL proved to be stable within a pH range from5.0 to 11.0, with significant decrease in activity at pH 2.0and 3.0. Immunological studies demonstrated that antiserum to HLT-LCL neutralized the cytotoxic activityof HLT induced by phytohemagglutinin (HLT-PHA)and HLT induced by PPD (HLT-PPD). Antisera tohuman IgG, lambda L-chains and the Fe fragment partially but significantly inhibited HLT-LCL activity.The data obtained from these studies and previous reports, indicate that HLT-LCL, HLT-PHA, and HLTPPD are similar in their purification, stability, and immunological characteristics. These studies also suggestantigenic similarity between the HLT-LCL molecule andthe IgG immuno-globulin.Metabolism of Lipoproteins by the Rat LiverBy Lawrence Pottenger, Ph.D.Sponsor: Dr. Godfrey GetzDiscussant: Dr. Angelo ScanuFeeding rats a one per cent orotic acid diet has beenshown to completely inhibit the secretion of serum lowdensity (LDL) and very low density (VLDL) lipoproteins from the liver without grossly affecting the synthesis of either endogenous liver proteins or serum proteinsother than lipoproteins. The inhibition of lipoprotein secretion is reversed by intraperitoneal injection ofadenosine. Orotic acid inhibited livers were studied in anattempt to gain insight into the synthesis and assembly ofVLDL.Inhibition by orotic acid lead to accumulation of lipidparticles (liposornes) within membranes' studded withribosomes. Intraperitoneal injection of adenosine causedthese particles to condense into smaller particles whichfinally appeared in the Golgi apparatus morphologicallyindistinguishable from VLDL.Liposomes and VLDL were isolated by ultracentrifugation, then delipidated and their apoproteins werepurified by Sephadex gel filtration and preparativepolyacrylamide electrophoresis. Four apoproteins fromliposomes were shown to be identical to correspondingVLDL apoproteins by either electrophoresis or immunological techniques. One apoprotein of VLDLwhich had no counterpart among liposomal apoproteinswas shown to be immunologically identical to anotherVLDL apoprotein and a liposomal apoprotein. Carbohydrate analysis by gas-liquid chromatography demonstrated that this apoprotein contained one residue ofgalactose and hexosamine and three residues of sialicacid while its immunologically identical counterparts inVLDL and liposomes contained no carbohydrate. Thelack of carbohydrate in liposomal apoproteins is considered to be due to their entrapment in the rough endoplasmic reticulum away from the glycosylating enzymesof the Golgi apparatus.The orotic acid induced fatty liver appears to be a use-ful model for studying the synthesis of components ofVLDL. Reversal- of inhibition with adenosine may be auseful model for studying the assembly of componentsinto mature VLDL particles in vivo.Physicians' Prediction of Local Recurrence ofCarcinoma of the Rectosigmoid and RectumBy Peter ReeSponsor: Dr. James MarksDiscussant: Dr. Bernard LevinEach year some 24,000 new cases of carcinoma of therectosigmoid and rectum are discovered; of these, 10 to20 percent go on to develop a local recurrence. It wouldbe desirable to predict which patients will recur so wemight offer additional therapy.A retrospective study of patients undergoing anteriorperineal resection at The University of Chicago Hospitals and Clinics was conducted to see if clinical physicians could predict local recurrence. Four clinical physicians, a pathologist, radiotherapist, surgeon, and oncologist were given the clinical information which wouldbe available after surgery and asked independently topredict in which patients the disease would recur. Separately, the actual outcome was recorded from the patients' charts.It was found that, although physicians' estimationswere slightly better than random, no physician's prediction was statistically significant. In our institution 23.6percent of the patients had a local recurrence; this rateremains unchanged since 1943. Positive lymph nodes andlocal spread of tumor were significantly related to localrecurrence. Duke's class C, location low in rectum, andyoung age of patient seemed related to local recurrencebut not significantly. Histologic grade of the tumor wasnot related to local recurrence.Our study has demonstrated that clinical physiciansare unable to predict which patients will have a localrecurrence, however, a number of factors have beenshown to be related to this problem. It is still undetermined whether physicians, with experience, will be ableto discriminate which patients will have a local recurrence.Noninvasive Measurement of Regional TissuePerfusion Using 81"' Kr/81RbBy Barry RichSponsor: Dr. Paul V. HarperDiscussant: Dr. Paul HofferFollowing intravenous injection, 81 Rb (T1I2 = 4.6h) is?Istributed in the intracellular space similarly to its chernI�al analogue, potassium, and changes only slowly withtime. The 13-second daughter, 81'" Kr is highly diffusibleand is removed from an organ at a rate proportional to the Frank Seiferttissue perfusion. Thus, by measuring the Kr/Rb ratiowhich is possible because of their, differing principalgamma energies, a measure of regional tissue perfusion isobtainable. This type of data is otherwise only availableusing invasive arterial catheterization techniques.In order to apply this method in practice, it is desirableto utilize radioscintigraphic imaging techniques. This allows measurements in regions of interest. Interfacing adigital data acquisition system with an Anger camerapermits quantitation of activities in small regions withresolution of 1 cm.Previous attempts to use this technique have been hindered by the interfering radiations of the contaminant82'" Rb, produced in large quantity along with the 81 Rbwhen the traditional bromide target is bombarded withalpha particles. A new production method, bombardmentof krypton gas enriched to 40 percent 8°Kr, with 8 MeVdeuterons, was investigated and found to yield 81 Rb inuseful quantities without concurrent production of theunwanted 82'" Rb.Regional perfusion of the myocardium has been investigated in primate and human subjects. Using a lifelikechest-heart phantom to simulate the zero-flow situation,myocardial perfusion rates were found consistent withthose reported for normal subjects. The short half-life of81 Kr results in a rapid buildup to equilibrium so that arapid flow is required to cause significant depletion.�hus, o_nly those organs with high perfusion rates (heart,liver, kidney) can be investigated with this technique.T�e Tip as a Developmental Organizer InDictyostelium DiscoideumBy Jonathan RubinSponsor: Anthony RobertsonDiscussant: Edward Garber, Ph.D./? discoideum amoebae feed on bacteria. When the foodIS eaten,. th� amoebae aggregate by producing achemotactic signal, The aggregate contains up to 105 cellsand. undergoes complex morphogenetic movements producing a migratory "slug" which transforms to a fruitingbod� �o.nsisting of two cell types, stalk cells and spores.An initially homogenous population of separate cellst�erefor� develops as a multi-cellular organism producingdifferentiated cell types.79I have investigated the control of the multi-cellular development. All multi-cellular stages possess awell-defined anterior tip. Tip removal stops morphogenesis and differentiation until a new tip forms. Tipsfrom all stages can be grafted into all other stages and willorganize a new developmental axis. All tips act in qualitatively the same way.The signal produced by the tip was observed both forits qualitative temporal behavior and its identity. Thesignal causing aggregation is c-AMP and the aggregateproduces it in periodic pulses.When tips are placed into fields of competent amoebae,however, the amoebae chemotax through continuousmovement. This continuous chemotaxis could be almostcompletely inhibited by adding a c-AMP phosphodiesterase to the washed amoebae.Because aggregated amoebae have a short refractoryperiod and the tip produces a continuous signal ofc-AMP, it is able to entrain cells attracted by any autonomously periodic signal. Mid-sections of slugs placedinto fields of competent cells produce random pulses ofchemotaxis toward them. These movements are reminiscent of the random waves propagated through a field ofamoebae just before aggregation. The tip's continuoussignal therefore seems to control development throughout the life cycle.Jonathan RubinStomach Dependent Gastrin Induced Hypocalcemia in the RatBy James A. SchulakSponsor: Dr. Edwin L. KaplanDiscussant: Dr. Irwin RosenbergGastrin, a polypeptide hormone secreted by the gastricantrum, has been demonstrated to induce transienthypocalcemia in the rat. This response has been attributed to a gastrin induced thyroid release of calcitonin.Our data, however, suggests a different mechanism-that a factor associated with the presence of an intactstomach may in fact be responsible for this observation.Fasted, young male Holtzman rats were injected in-20 travenously with either synthetic human gastrin, porcinegastrin, or saline as a .control. Venous blood was collected immediately pre-injection and at 15, 30 and 60minutes post injection. Serum calcium (Ca) was measured by atomic absorption spectrophotometry.Either synthetic human gastrin or porcine gastrin in adose of 25 ug/rat produced a significant (p < 0.001)hypocalcemia at both 15 and 30 minutes with serum Careturning to the control level at 60 minutes. In these experiments the decrease in serum Ca was approximately20 percent. When gastrin was injected intothyroparathyroid-ectomized (TPTX) rats, a similarpattern of hypocalcemia was observed with a fall of Ca inthe order of 12 percent. Addition of nephrectomy, adrenalectomy, or enterocolectomy did not ablate this gastrin induced hypocalcemic response. Gastrectomy, however, completely abolished this response in both thyroidintact and TPTX animals.The gastric factor that mediates gastrin inducedhypocalcemia in rats is presently unknown. Peak gastrininduced hypocalcemia coincides temporally with peakgastrin induced acid secretion in the rat. Systemic acidbase changes associated with gastric acid secretion mayoffer an explanation. On the other hand, a new humoralfactor from the stomach may be responsible for this effect on calcium metabolism. This data is particularly interesting in view of recent observations by others relatingsystemic calcium fluctuation with the regulation of gastric function. Studies are continuing in our laboratory tofurther elucidate this phenomenon.The in vitro Effects of the Corticosteroids on theFunction of Human Blood PlateletsBy Frank SeifertSponsor: Dr. Robert ReplogleDiscussant: Dr. Joseph BaronRecent advances in our understanding of blood plateletshave emphasized. the active and primary role of plateletsin the genesis of thromboembolic phenomena. The adhesion and aggregation of platelets, induced by a variety ofphysiological stimuli, including ADP and collagen, en-Lawrence Pottenger Barry Richjoys independence from the plasma coagulation system.Recognition of this independence has stimulated research for anti platelet agents that would allow the clinician to selectively control platelet reactions, much as henow controls the generation of thrombin with heparin orcoumadin. Although many anti platelet agents have beenidentified, only aspirin and dipyridamole have receivedextensive clinical trials, and the results have been largelyinconclusive.The effect of adrenal corticosteroids on in vitro plateletfunction was investigated. Significant inhibition of bothADP and collagen induced platelet aggregation in thepresence of high concentrations (greater than 10-3 Molar)of hydrocortisone, methylprednisolone, and dexamethasone was demonstrated. An 80 to 90 percent inhibition of platelet aggregation was produced with optimal doses; a decrease in the rate of aggregation was alsoobserved. Whereas hydrocortisone and methylprednisolone were equally potent in their effects, dexamethasone was found to be somewhat less potent. Prolonged incubation of platelets with these steroids wasfound to enhance the inhibitory effect. Suboptimal dosesof these steroids produced a rapid reversal of maximalaggregation after ADP but not collagen induction. Theselatter two phenomena suggest that steroids may act onplatelets primarily by inhibition of the release reaction.The effect of methylprednisolone on platelet adhesiveness was found to be highly variable, and requires furtherstudy.The concentrations of steroids used to affect plateletaggregation in this study are considerably higher thanthose acceptable for clinical use. No significant inhibitionof platelet aggregation could be demonstrated in patientsreceiving 25mglkg of Solu-Medrol, Nevertheless, it isstill felt that the role of corticosteriods as clinical antiplatelet agents deserves further study; dipyridamole, whenshown to significantly decrease the incidence of thromboembolism in certain clinical situations, was used inconcentrations too low to inhibit in vitro platelet aggregation. The relationship between the in vitro inhibition ofplatelets and the inhibition of platelet activity in vivoremains a major problem of platelet research.Regulation of the Immune Response with Antigen Specific IgM Antibody: A Dual RoleBy William M. Wason, Ph.D,Sponsor: Dr. Frank FitchDiscussant: Dr. Donald RowleyModification of the immune response by passive immunization with antigen specific antibody has beenstudied for over 50 years. IgG antibody generally inhibitsactive antibody formation. However, the regulatory effects of IgM antibody are more controversial and manyapparently contradictory reports have appeared in theliterature.These studies were undertaken to better elucidate the James Schulak William Wasonregulatory role that IgM antibody might play in the immune response. IgM a-SRBC antibody administered before antigen produced an augmented response to a suboptimal dose of sheep erythrocytes (SRBC) in the mouse.The same dose of IgM a-SRBC antibody, which elicitedan augmented response when given before the SRBC,caused a significant suppression of the immune responsewhen given 1 or 2 days after the SRBC. In vitro, IgMa-SRBC antibody suppressed the response of culturedmouse spleen cells to all doses of SRBC, whether givenbefore or after immunization. In the intact mouse, IgMa-SRBC antibody apparently augments the primary immune response to low doses of antigen by increasing thenumber of SRBC localized in the spleen. Antibody mustbe present at the time of injection of the antigen for thiseffect to occur. However, IgM antibody can also act tosuppress antibody-forming cells after antigen localizationhas occurred. Thus IgM antibody appears to playa dualrole in the regulation of the immune response in themouse.Augmentation of the immune response could not bedemonstrated in two strains of rats tested. Therefore, itremains to be determined if the dual effect of IgM antibody on the immune response in the mouse can be extrapolated to other species.Francis Straus II was chairman of the Senior Scientific Session.21Internship and Residency MatchingNearly half of the students graduating from The University of Chicago Pritzker School of Medicine Class of1974 entered first year residency programs this July. Thisreflects a growing trend among medical students towardsmoving directly into a specialty. This year, 40 of the 87graduates chose this course; most will do their residencies in pediatrics or surgery. These figures show amarked increase over two years ago when only 6 studentswent into first year residencies. Most of those whoselected internships have indicated a preference for internal medicine and many students have chosen to gointo psychiatry. Of the 85 students who participated in the NationalInternship and Residency Matching Program, 41 wereselected by the hospitals of their first choice. Fourteenwere matched to hospitals of their second choice and 11received their third choice. Eight arranged their own appointments in teaching hospitals subsequent to the announcement of the matching results. One student postponed his internship for one year and another will begin atwo year post-doctoral fellowship at the Center for National Scientific Research in France. The remaining 85began their first year clinical appointments as follows:Int. Resid.Renee Band University of Chicago Clinics PeIra Bergman Massachusetts General Hospital PeIrma Bland University of Chicago Clinics PsySteven Blau University of Arizona Affiliated Hosps. SDavid Bonacci Northwestern Hospital, Minnesota MThomas Brott Beth Israel Hospital MJoseph Butterfield Philadelphia General Hospital R-9Norman Byers Walter Reed Hospital R01 iver Cameron University of Michigan Affiliated Hosps. MLinda Chao Ph i ladel ph ia General Hospital R-9Charles Cobb Presbyterian University, Pennsylvania SDaniel Cooperman University of Chicago Clinics SDavid Crnic University of Colorado Affiliated Hosps. SRobert Dinsmore Bronx Municipal Hospital Center MEdwin Doublass St. Louis Children's Hospital PeCharles Eil University of Michigan Affiliated Hosps. MMichael Fauman University of Chicago Clinics PsyKathleen Flohr University of Minnesota Hospitals Mjanice Frank Northwestern Memorial Hospital-V.A. MJohn Gallagher N. Y. Hospital-Cornell Cooperati ng Hosps. SPamela Gallagher N.Y. Hospital-Cornell Cooperating Hosps. SKenneth Gass Children's Medical Center, U. Hosp., Seattle PeTheodore Glatz University of California Affil. Hosps., L.A. PeSamuel E. Goldman Michael Reese Hospital MRosalba Gomez Michael Reese Hospital MMarc Graff Strong Memorial Hospital R-6Ruth Grant Vanderbilt University Affiliated Hospitals Mjames Hedrick University of Kentucky Medical Center PeEarl Henry University of Chicago Clinics MDonnis Hobson Northwestern University Medical Center SSusan Hoch Boston City Hospital MRichard Horne University of Minnesota Affiliated Hosps. FP'Stephen Jennings University of Chicago Clinics SRoyce Johnson University of Chicago Clinics Opjames Kahn University Hospitals, Madison MSimon Kan University Hospitals, Madison RaGerald Karnow Harlem Hospital MRobert Kaufman University of Michigan Affiliated Hosps. RaBeverley Ketel University of Chicago Clinics SThomas Krueger University of Chicago Clinics Pe22Int. Resid.Thomas Kubota Vanderbilt University Affiliated Hospitals MDavid Lake Mount Zion Hospital, S.F. R-6Kenneth Leung University of California Affil. Hosp., Davis R-OEdward Linn Michael Reese Hospital ObRichard Longley Cook County Hospital MLewis Margol is Yale-New Haven Medical Center PeRodger McEver Barnes Hospital Group, St. Louis MMichael Mcllhany University of Chicago Clinics 5Waymann Merrill Martin Luther King Hosp., L.A. MGregory Milmoe Hospital of the University of Pennsylvania 5Richard Minter Denver General Hospital R-6William Montgomery University of Colorado Affil. Hosp. 5Sol Nevins Vancouver General Hospital, Canada 5Roland Ng L.A. County-USC Medical Center MSteven 0' Neal Henry Ford Hospital, Detroit MGeorge Papas Michael Reese Hospital MMichael Penley V.A. Hospital, U. of California, Irvine MTheodore Polley University of Michigan Affiliated Hosps. 5Lawrence Pottenger johns Hopkins Hospital 5Peter Ree Mount Zion Hospital, S.F. R-9Barry Rich Children's Memorial Hospital PeNiles Rosen University of Chicago Clinics Pajonathan Rubin University of Chicago Clinics Rajudith Rybarczyk V.A. Hospital, U. of California, Irvine MKenneth Sakauye University of Iowa Hospitals Mjames Schulak University of Chicago Clinics 5Howard Schwartz Vanderbilt University Affiliated Hospitals MPeter Schweibert Edward W. Sparrow Hospital, Michigan FPFrank Seifert University of Chicago Clinics 5David Smith University of Minnesota Hospitals 5Norman Sobol State Univ.-Kings Cty. Hosp. Cen., NYC MElisabeth Sommerfelt Strong Memorial Hospital Pejames Soong State Univ.-Kings Cty. Hosp. Cen., NYC Mjames Stankiewicz University of Chicago Clinics 5Howard Strassner Presbyterian Hospital, NYC ObNathan Szajnberg University of Chicago Clinics PeStewart Taylor University of Chicago Clinics 5Mark Tolpin University of Oregon Med. Sch. Hosps. PePaul Volkman Duke University Medical Center PeAnne Ward Michael Reese Hospital ObWilliam Wason University of Chicago Clinics MPaul Wasserman University of California Affil. Hosps., L.A. Pejames West Hospital of the University of Pennsylvania MRoger White Northwestern Memorial Hospital-V.A. MAnna Wu Northwestern Memorial Hospital-V.A. MRonald Yamada L.A. County-USC Medical Center 5Lawrence Aggerbeck Post Doctoral Fellowship, FranceAmy Hamburg Postponed InternshipBruce Richardson Graduate Study in ImmunologyRobert Waterston (1972) Children's Medical Center, Boston PeTOTALS 47 39INTERNSHIPSKEY: R=RotatingM=Straight MedicineS=Straight Surgery RESIDENCIESKEY: FP= Family PracticePa=PathologyPe= PediatricsPsy = Psychiatry Ob = Obstetrics/GynecologyOp = OphthalmologyRa = RadiologyS=Surgery23A NEW Thrust In BiologyThe comings and goings of insular ants may seem inconsequential to the non-specialist. But for populationbiologist Richard Levins, systematic study of ants yieldsdata for a theory he is developing to determine howspecies co-exist with other species and with the environment. Modeling the interrelationships of all the contributing factors is a relatively new methodology: themathematical theory of complex systems. This approachis being applied by Levins to much of his work on systems where only partial information is available. He is,for example, using it to facilitate research on how to:distribute food to the hungry; develop non-toxic pestcontrols and prevent eutrophication of the lakes. As theinterconnections become more complicated in nature, hesays, mathematical techniques must be applied to biological exploration.The most difficult general problem of contemporaryscience is how to deal with complex systems as wholes,he says. "Most of the training of scientists, especially inthe United States and Great Britain, is in the oppositedirection. We are taught to isolate parts of a problem andto answer the question 'what is the system?' by tellingwhat it is made of. This is a very limited research tool. Itmay tell us what is there, but not what is happening. Thedramatic advances in our generation have almost all beenin areas where a reductionist approach is practicable.The notable stagnations have been in areas which areintrinsically complex systems. It is now a commonplace,at least in ecology, that systems are complex and that theone-step linear causality is a poor predictor of ultimateoutcome. "Levins and his co-workers studied 55 species of ants inthe Caribbean over the past eight years. The scientistsmaintain that topography, weather and the mode of life ofeach kind of ant all help dictate the make-up of the environment. Levins says "The mathematical approach tobiogeography focuses on the opposing processes of migration and extinction. Both migration and extinction depend on the biology of the individual species and theways they interact."If one were to look at the problem of assuring adequatedistribution of food to the entire population, on a singlecomponent basis, he continues, the information gatheredwould not be complete. He says, "Since insects destroya significant portion ofthe world's crops, and since insecticides can be shown in the laboratory to kill insect pests,it is a plausible inference that the use of insecticides willcontrol insects and increase available food. But it oftendoes not work this way, for two main reasons. First, theapplication of insecticide does not necessarily control theinsect pest-the target group, through natural selection,can build resistance to the chemicals. Moreover, insecticides kill the predators, so that while more pests arepoisoned fewer get eaten. "Secondly, even the obviousexpectation that increased food production alleviates24 hunger proves false. The whole domain of agriculturaleconomics, grain prices, trade agreements, credits forfarmers, commodity speculations, land concentrationand speculation intervenes between the harvesting of thecrop and the feeding of hungry people." He says, "Scientists have, up to now, manipulated nature by bruteforce and the use of toxic chemicals. As a member of theNational Academy of Science's Regional Task Force onPest Control, he is looking for devices which will notharm the environment. The task force is doing preliminary work now, to understand the problem and to look atpossible solutions. Researchers are already consideringthe possibility of using predators instead of toxic gases.He predicts that ants might someday provide an effectivealternative for pest control.Recent findings of the American Medical Associationtake issue with the premise that toxic control is "evil."In a book titled Environmental Quality and Food Supply,the authors maintain that there is a greater health riskfrom mass starvation than from pesticides and chemicalfertilizers. They claim "pesticides are necessary to keepup the absolutely vital high production of food."Levins counters that "pest control is dependent onchemical pesticide only because these are the methodsthat have been researched and because Americans likemagic bullets. But alternative approaches to pest controlpromise to reduce greatly the dependence on toxic substance while maintaining adequate food production. Wedo not have to choose between being starved or beingpoisoned. "Although viewing the whole is "less understood andtherefore more difficult than observing the parts," Levins insists that it is necessary approach."In the study of the eutrophication of lakes it is relatively easy to measure the changing concentrations ofminerals and abundances of species. Laboratory experiments can show single link relations between variables ina lake system. But in order to understand the processesoccurring in the lake we have to model the whole systemwith direct effects and indirect feedbacks. This requires aclose integration. of mathematics and biology."Although the study of stable systems may seem moreattractive and simple," Levins says, "nature is rarelystable and the study of patterns of change is more realistic and necessary. Fortunately, it is also more interesting."Besides changing the approach they use, Levins wouldlike to alter the entire thrust of the research of his fellowscientists. He charges that they are working against eachother instead of in cooperation with each other, thus undercutting the effect of one another's findings. At present, he claims, there are two camps of biologicalinquiry-one employs practical research and the otherdeals solely with theory. The two must be joined, hesays, if either means of research is to have any practicalapplication."Agricultural research in the United States, whetherfederally supported or carried out by the agriculturalchemicals industry, seed companies or the faculties ofagricultural colleges, has suffered from a narrow pragmatism that is reinforced by the general indifference ofresearchers in 'basic science' to problems of agriculture.They tend to work on an anti-theoretical basis, searchingfor chemical products as the central strategy for improvement of agriculture. At the same time, basic science often ignores the practical applications of researchas it gets lost in abstract theories." Individual researchers, in both camps, he says will have to take theinitiative to close the gap.A man with many interests, Levins has been involvedin at least a score of projects over the years. One of the"more interesting, but unfortunately aborted," of thesewas an application for a grant from the North Vietnamese government in 1971 for bibliographical researchinto what might be done to reforest areas which had been"defoliated by U.S. military herbacides and to find newuse for lands destroyed by bombs." The North Vietnamese government had approved a $700 grant for thestudy. But the United States Department of the Treasurythwarted it on the grounds that North Vietnam was an"enemy" to our country.Selecting areas for study is perhaps the most importantand most difficult task of the researcher, according toLevins. "The most popular problems in a field are notnecessarily the most significant. In choosing a researchdirection the scientist should examine the history andtraditions of her/his discipline, decide why it has its present priorities, evaluate these critically, and then set aprogram of one's own. Too much of contemporary research consists of elegant solutions to trivial problemsbecause young scientists are assimilated into a specialtywithout first looking at it from the outside," he says.He feels that the population biologist must learn aboutmany areas of fundamental agricultural research. Thefirst of these is natural selection within communities."There is a suggestion that feedbacks within the community may result in a species selecting itself to localextinction. Manipulation of community parameters canharness selection to our ends," Levins says.Other topics include: The genetics of expandingspecies; the study of the distribution of pests and theirpredators over a region within the framework of theextinction-migration theory of quantitative biogeography; host location in a heterogeneous environment; theprocess of niche shift in the origin of past species and theartificial selection of control organisms.Population biology is composed of ecology and genetics. As practiced by Levins, it also involves sociology,anthropology, physiology, developmental biology andbioclimatology. He applies the inter-disciplinary methoddaily as he teaches in the Departments of Biology andBiophysics and Theoretical Biology. He is also a memberof the Committees on Evolutionary Biology, Geneticsand the Conceptual Foundations of Science and teachesin the College.Levins works with students in all areas of interest. Heregards the teaching as inseparable from his research. "Itis in the course of brainstorming, mutual criticism, andplanning both independent and joint investigations thatthe most creative science takes place." As a result, thelaboratory and his office are places of constant interchange and discussion. Diabetes-Endocrinology CenterThe University of Chicago has received a U.S. government grant to establish a Diabetes-EndocrinologyCenter. The first-year grant of $266,819 was effectiveJune 1. A five-year total of$1.3 million is foreseen by theNational Institute of Arthritis, Metabolism, and Digestive Diseases, the funding foundation.The grant will strengthen and extend interdisciplinarydiabetes research already underway by scientists in ninebasic science and clinical Departments at the Universityand at Michael Reese Hospital and Medical Center,which is affiliated with The University of Chicago. Participants involved in the Center are:D. F. Steiner (56)A. LernmarkH. S. TagerI. G. Wool (53)J. FriedC. CoulterJ. BorensztajnF. Thorp (60)A. LawrenceA. RubensteinJ. Skosey (61)D. Horwitz (67)L. FrohmanM. Stachura BiochemistryBiochemistryBiochemistryBiochemistryChemistryAnatomyPathologyPediatricsMedicineMedicineMedicineMedicineMichael ReeseMichael ReeseStudies at the Center will focus on Diabetes Mellitus, amultifaceted metabolic disorder in which the ability toutilize glucose is impaired, usually due to a deficiency incirculating insulin. This results in hyperglycemia (highblood sugar), symptoms of thirst, hunger, emaciation andweakness and in its most severe form, ketoacidosis. Anestimated four per cent of the U.S. population is affectedby diabetes. The disease occurs in both children andadults, and it often limits life span, even when the patienttakes insulin injections. Long-term complications includeheart disease, blindness, cataracts and kidney disease, allbelieved to be tied to insulin deficiency."The major emphasis," says Center Director Dr.Donald Steiner, "will be on expanding our knowledge ofthe islets of Langerhans, which are made up of cells thatproduce the hormones insulin and glucagon." The isletsare tiny cell clusters, each about the size of a pinhead,which are scattered throughout the pancreas. The humanpancreas contains up to 2 million such islets. The research program will examine in detail the functions of thealpha and beta cells in the islets. Alpha cells produceglucagon and beta cells produce insulin. These hormonesregulate the sugar content of the blood. Insulin also playsan important role in normal growth processes and in conserving vital proteins in the body. It is believed that thebasic defect in diabetes involves faulty insulin secretionby the pancreatic beta cells. Dr. Steiner says.In the normal production of insulin, the islets synthesize a single chain precursor protein known as proinsulin,which was discovered by Dr. Steiner in 1967. This25�C-PEPTIDE�Diagram of human proinsu/in structure.molecule consists of the A and B chains of insulin linkedby a connecting region, called the C-peptide. After thetwo chains are folded into their final position, a processthat is dependent upon the presence of the C-peptide,this part of the molecule is cleaved off, according to Dr.Steiner. The insulin and C-peptide are then stored insecretory granules awaiting release from the beta cells inresponse to body needs. Somewhere in this process, thediabetic may have a defect, which prevents the efficientmanufacture and/or secretion of insulin. "Most diabeticsalso have decreased numbers of islets and of beta cellssuggesting that the diabetic beta cells lack the ability torespond to normal growth stimuli. In this respect diabetes might be considered an antipode of cancer wherecells in a certain area of the body also fail to respond tonormal growth signals and instead they grow out of control. Progress in understanding the basic mechanismscontrolling cell growth may ultimately lead to the conquest of both cancer and diabetes," he says."Insulin was the first protein hormone to be isolated incrystalline form and to have its amino acid sequence determined. And yet we still know relatively little aboutdiabetes and about how insulin works at a molecular leveldespite the great amount of work that has been donesince the discovery of insulin in 1921. But, there is muchevidence indicating that some kind of defect, probablyinherited, within the islets themselves, is responsible for26 diabetes. It is not clear yet whether there is just onedefect or several, and how these inherited changes mightreduce the capacity or produce insulin. The Center's objective is to encourage interdisciplinary research on allbasic aspects of islet function-how the cells divide,what makes them divide or not divide, how the size ofthis organ and its function is regulated. We believe thatthe detailed studies to be carried out will lead to a betterunderstanding and eventually, more effective treatmentof diabetes."The grant will facilitate laboratory and clinical investigation of the secretory products of normal and pathological islets; the natural history of diabetes, beta cell regeneration and replication; diagnosis and treatment of malignant and non-malignant islet tumors; insulin biosynthesisand phylogenetic relationships; proinsulin and C-peptidestructures, metabolism and biological activities;mechanism of action of insulin in regulating the biosynthesis of RNA and protein in sensitive tissues; binding,metabolism and degradation of insulin in the liver; lipidmetabolism in diabetes and the role of the central nervous system and prostaglandins in hormonal regulation.While some new research initiatives will be supportedby the grant, its main function will be to provide a moreclosely coordinated effort and new equipment for variousinvestigations. New laboratory facilities will includeareas for:-antibody production and immunoassays for peptide hormones,-cell and protein fractionation, to prepare materials for study,-islet and liver cell preparation and tissue culture,to study the growth and developmental aspects of isletcells and the effects of hormones on normal and malignant cells in tissue cultures.The new Center is one of four geographically disperseddiabetes-endocrinology units reportedly planned by thegovernment this year.Dr. Steiner is the A. N. Pritzker Professor and Chairman in the Department of Biochemistry and Professor ofMedicine in the University's Division of the BiologicalSciences and The Pritzker School of Medicine.Dr. Arthur Rubenstein, professor of endocrinology inthe University's Department of Medicine, will be program director. He has been credited with successfullyapplying many of the findings of Dr. Steiner's laboratoryto clinically important problems. Dr. Rubenstein showedthat the C-peptide was secreted together with insulin into,the circulation and that its blood level can be used toindicate the amount of insulin being produced in diabeticpatients receiving insulin injections. This technique thuspermits one to monitor islet cell function over the longterm in these patients. Until this discovery was made,there was no way to assess insulin secretion once injections were necessary. Dr. Rubenstein has found that thediabetic often continues to produce some of his own insulin, and this may possibly be important in minimizinglong-term complications. "In the cases in which thediabetic does continue to secrete insulin, the treatment isusually more effective than when the process has completely ceased," he says.Clinical aspects of the program will use existinggovernment-funded General Clinical Research Centersin Silvain and Arma Wyler Children's Hospital and Billings Hospital at the University. Their government subsidized beds will be used for patients who will be involved in the long-term study of the disease. Youthfuldiabetics who are first seen in the Wyler Hospital can besystematically followed when they are later seen asadults in Billings Hospital.Dr. Lawrence Frohman will direct the Michael Reesecomponent of the Center's program. A neuropharmacologist, he is Professor (MRH) in the Department ofMedicine at the University and is director of endocrinological research at Michael Reese. Dr. Frohmanwill study the influence of pharmacological agents onalpha and beta cell activity in the pancreas.Drs. Steiner, Rubenstein and Frohman will constitutethe Center's Steering Committee, which will guide thescientific operation of the Center. Additional members,in an advisory capacity, will be Professor Elwood Jensen, Professor Hewson Swift, Dr. Henry T. Ricketts,Dr. Dorothea Turner, Professor Robert Uretz, and Dr.Clifford Gurney of The University of Chicago.Among those whose research will be facilitated by theCenter are:-Dr. Steiner: Studies on the formation, structure andmechanism of action of insulin and related islet hormones in a wide range of vertebrate species and in man. Included are studies of insulin binding, action and degradation in normal and neoplastic tissues, studies with synthetic analogs of insulin, proinsulin and C-peptide, carried out in cooperation with scientists in Germany andJapan, and comparative X-ray studies of the threedimensional structure of insulin.-Dr. Ira G. Wool, the A. 1. Carlson Professor in theDepartment of Biochemistry: Studies of the mechanismwhereby insulin and other hormones participate in theregulation of protein synthesis in animal tissues.-Josef Fried, the Louis Block Professor in the Departments of Chemistry and Biochemistry: Synthesis andbiosynthesis of prostaglandins and prostaglandinanalogs. Prostaglandins appear to modify the sensitivityof cells to hormones-such as insulin, and also have beenimplicated in some inflammatory processes.-Dr. Howard Tager, Assistant Professor in the Department of Biochemistry: Studies on proglucagon andthe biosynthetic pathway for glucagon formation in thealpha cells. Studies on mechanisms regulating insulinsecretion from beta cells.-Dr. Ake Lernmark, Visiting Assistant Professor in theDepartment of Biochemistry (from the University ofUrnea, Sweden): Studies on the plasma membranes ofisolated beta cells from normal and abnormal or neoplastic islet tissues.-Dr. Charles Coulter, Assistant Professor in the Department of Anatomy: X-ray crystallographic studies oninsulins from primitive vertebrates.-Dr. Frank K. Thorp, Associate Professor and theJoseph P. Kennedy Jr. Scholar in the Department ofPediatrics: Studies on hypoglycemia (low blood sugar) ininfants and children. Studies of juvenile onset diabetesand of methods to teach juvenile diabetics proper dietand care.-Dr. John L. Skosey, Assistant Professor in the Department of Medicine: Studies an adipose tissue and fatcell metabolism.-Dr. Jayrne Borensztajn, Assistant Professor in theDepartment of Pathology and the College, and DeputyDirector of Clinical Operations, Clinical Chemistry, Billings Hospital: Research on the transport andmetabolism of plasma triglyceride fatty acids, includingthe role of insulin in regulating lipoprotein lipase activityin the heart.-Dr. Frohman: Neurological influences on insulin production. Dr. Frohman's studies have suggested that adrenal secretions play an important role in insulin production.-Dr. Ann M. Lawrence, Professor, Medicine: Studieson growth hormone secretion in diabetics, impaired glucose tolerance in hypopituitary patients, glucagonstudies, studies of growth hormone and glucagon in obes-ity. .-Dr. Rubenstein: Measurement of proinsulin andC-peptide in the circulation, and in urine. Studies on thenatural course of diabetes and its complications in man.-Dr. David L. Horwitz, Instructor, Department ofMedicine: Studies of islet function in diabetic patientsusing human C-peptide immunoassays.27Seminar/Cruise to Greece and RussiaThe University of Chicago Medical Alumni Associationinvites alumni and faculty to its first Continuing Education Seminar/Cruise to the Greek Isles and RussianRiviera aboard the Royal Viking Sky September 19through October 5, 1975.Seminar subjects will be offered on recent advances in:Carduiology Dr. Louis Cohen, ('53)Associate Professor, Department of Medicine, TheUniversity of ChicagoEndocrinologyDr. Ann M. LawrenceProfessor, Department of Medicine, Stritch School ofMedicinePediatrics-GeneticsDr. Albert Dorfman Ph.D. ('39) M.D. ('44)Richard T. Crane Distinguished Service Professor,Department of Pediatrics, The University of ChicagoPsychiatryDr. Daniel X. Freedman, M.D.Louis Block Professor and Chairman, Department ofPsychiatry, The University of Chicago,/ 'Application has. bAmerican AcadMedical Assoc]Category I I.28 September 22 Sail from Piraeus aboard the sleek, newcruise ship to the Cradle of Civilizationand the Black Sea to such ports as Constanta (Romania), Odessa, Yalta, Sochiand Sukhumi (Russia), Istanbul andIzmir (Turkey), and the Greek Islands including Rhodes and Crete.In each port, a privately arranged shoreexcursion will be provided.October 5 Return to Piraeus in the morning. Leavefrom Athens Airport arriving in NewYork same afternoon.Participants travel first class. Fees start at approximately $1890 and include special group air transportationfrom New York to Athens and return, a complete threeday stay in Athens, the Royal Viking Line Cruise, allseminars, all special snore excursions and private receptions.Further details will be mailed to all alumni.Return to:Medical Alumni Association1025 E. 57th StreetChicago, IllinLetters:T-formationSidney Schulman, M.D. (46)Dear Sid:I very much enjoyed your presentation to the entering medical students. Ido think that you may have erred in oneimportant fact, however. I believe that Iam correct in remembering that the developer of the T-formation at the University of Chicago was not A. A. Stagg,but his successor Clark Shaughnessy.Shaughnessy, of course, could not useany kind of formation with the materialhe had against the competition he had toface; and, therefore, he became a consultant to George Halas who introduced theT-formation via Sid Luckman in anotherpart of Chicago.Warmest regards,Sincerely yours,Laurence Finberg, M. D. (46)Rush-U of C AffiliationDear EditorI have received my copy ofYolume 28No.3 of the Bulletin. I have enclosed acopy of Page 15 in which an error continues to be made.A couple of years ago someone statedthat "in 1941 Rush went out of existence." This statement is repeated inthis article. I presume that what they intend is the fact that the relationship tothe University of Chicago was terminated in that year. However, it is a factthat their graduating class of 1942 received their diploma at the University ofChicago and the diploma reads "RushMedical College of the University ofChicago. "This may appear to be a minor detailbut I am sure you would find considerable pride in memories of the graduatingclass.Sincerely,George H. Handy, M.D. Rush '42State Health OfficerNews BriefsFor He's a Jolly Good FellowDr. Lester R. Dragstedt, the ThomasD. Jones Professor Emeritus in the De- partment of Surgery, came back to theUniversity as a visiting professor duringMay.While here, he attended surgery conferences, rounds and lectures and participated in most department relatedevents, including the ground breaking forthe Surgery-Brain Pavilon and the 28thAnnual Senior Scientific Session. He delivered a special lecture on "Some Contributions of Physiology to SurgicalTreatment of the Peptic Ulcer."Dr. Dragstedt, a member of the National Academy of Sciences, in 1943 developed the vagotomy operation whichhas aided the recovery of thousands ofpeptic ulcer patients. The operation wasbased on his experimental evidence thatoveractivity of the vagus nerve in ani- mals stimulated overproduction of gastric acids.Dr. Dragstedt holds B.S. (15), M.S.(16) and Ph.D. (20) degrees from theUniversity, .and received his M. D. degree in 1921 from Rush Medical College,then a University affiliate. After servingon the faculties of the University of Iowaand Northwestern University, he joinedThe University of Chicago in 1925 asAssociate Professor of Surgery, becoming Professor in 1930, Chairman, 1948and the Thomas D. Jones DistinguishedService Professor, 1952. He retired fromthe University's faculty in 1959. Dr.Dragstedt is currently Research Professor of Surgery and Physiology at theUniversity of Florida's College ofMedicine.First Dr. Dragstedt teaches Dr. Hensley Miller, (left), a visitor from Toronto, David Hopp and RobertLipson, students, Dr. Shah Mansoori, a visitor from Michigan and Dr. Aldo Moraldi. ...... Then the tables are turned and the surgeon listens as Lipson talks about a problem.29Dr. Dragsteadt reminisces with his colleagues Drs. Leon Jacobson and Cornelius Vermeulen. Dr.Dragstedt, who was one of the first chairmen of the Department of Surgery, finds out what's new at theschool as he listens to the present chairman, Dr. David Skinner.Outstanding ResidentDr. Evans Fiakpui, (70) has beennamed the year's outstanding resident atthe Chicago Lying-in Hospital. The announcement was made at a party givenby the Board of Directors for the faculty,staff and residents of the hospital. It washeld at the home of University ofChicago President and Mrs. Edward H.Levi.Dr. Fiakpui is a native of Ghana. Hejoined staff of the Chicago Lying-inHospital as a resident in 1971 after completing his internship there. He has beeninvolved in research on sickle cellanemia. Dr. Fiakpui delivered a paper atthe annual meeting of the American College of Obstetrics and Gynecology onthe subject in 1973.In addition to a check for two hundreddollars Dr. Fiakpui will have his nameinscribed on a plaque at the Hospitalshowing him to be the second annualResident A ward Winner.Receives Ricketts AwardDr. Wallace P. Rowe, Chief of theLaboratory of Viral Diseases, NationalInstitute of Allergy and Infectious Diseases, received the 1974 Howard TaylorRickets Award of The University ofChicago for his contributions to the fieldof medicine. Dr. Leon O. Jacobson,Dean of the University's Division of theBiological Sciences and The PritzkerSchool of Medicine, presented the awardat an honorary dinner May 23. Dr.Rowe's topic for the annual HowardTaylor Ricketts Lecture was "Virusesas Genes in Mammalian Cells."The award was established in 1913 inmemory of the University of Chicago30 scientist who demonstrated that RockyMountain spotted fever is transferredamong men by ticks. Dr. Ricketts wasalso the first to observe and describe thesmall bipolar bodies that cause, the disease. Later he found-at the cost of hislife-the related organism that causestyphus fever. .The Ricketts A ward has been bestowed on some of the world's most distinguished scientists, including Dr.Jonas E. Salk, who discovered the firstpolio vaccine and Dr. Albert Sabin.Dr. Rowe was the first to recognizethe role of the immune response inpathogenesis of lymphocyticchoriomeningitis in experimental mice.He performed pioneering research leading to the discovery of the adenovirusesand their relation to human disease. Intumor virology, he helped establish thatviral ON A can be integrated into mammalian host cell genetic materials. Healso provided the' most convincingbiological proof in the studies of RN Athat genes of mouse leukemia virus arecomponents of host cell chromosomes.Miller Receives TitleDr. C. Phillip Miller (B.S. 1916, M. D.Rush 1919) received the title of Masterof The American College of Physiciansat the Convocation Ceremony April 1during the annual meeting of The American College of Physicians in New YorkCity. This is the highest honor given to aphysician by the College. Dr. Miller wasa member of the first faculty of the Medical School and served at the Universityfrom 1925 as Professor until he becameEmeritus in 1960. His professional lifehas been devoted to studying infections,infectious diseases, host factors in infec- tion and treatment. He is a master investigator, teacher, and clinician.Elected fellowUniversity of Chicago faculty member,Guy Williams-Ashman, has been electedFellow of the American Academy ofArts and Sciences. He was among 117outstanding U.S. scholars, scientists,public figures, artists, and writers namedto the Academy May 8. His election wasannounced at the Academy's 194th annual meeting in Boston.Mr. Williams-Ashman, the MauriceGoldblatt Professor in the Ben MayLaboratory for Cancer Research and theDepartment of Biochemistry in theUniversity's Division of the BiologicalSciences and The Pritzker School ofMedicine, is an expert on male sexualphysiology. He has made many contributions to' the field of male sex hormone action and to the physiology ofsperm cells.The Academy is the second oldestlearned society in the United States,with a membership of 2,300. It wasfounded in 1780 as a national honorarysociety. It carries on an active interdisciplinary program of study and publication on major national and internationalproblems.Langer AwardBernard Roizman, University ofChicago virologist, has received the 1974Esther Langer A ward for his outstandingcontributions to cancer research. Theaward, consisting of $1,000 and acertificate, was made by the Ann LangerCancer Research Foundation at a dinner, June 2. Conditions of the award arethat its recipient be 45 years of age orunder and a resident of the continentalUnited States.Roizman is an international authorityon herpesviruses. The Esther Langeraward cited his contributions to thestudies of the molecular biology ofherpesvirus infections as they relate tohuman cancer.He is Professor and Chairman of theCommittee on Virology and Professor inthe Departments of Microbiology and ofBiophysics and Theoretical Biology inthe University's Division of the Biological sciences and The Pritzker School ofMedicine.Macy AwardsDr. Irwin H. Rosenberg, Associate Professor in Medicine, has been named arecipient of a Macy Faculty ScholarAward for 1974-75 by the Josiah Macy,Jr. Foundation of New York City. Hisaward provides for travel while he is engaged in research. Dr. Noel W. Solomons, a fellow in Medicine, was recently named a Macy Faculty Fellow.His award is for three years with an initial annual stipend of $18,000. Dr. Solomons also was named principal investigator for a three-year study on"Malabsorption and Malnutrition inChildren in Pre-Industrial Nations."The Nutrition Foundation has granted$10,000 per year to this study.Guggenheim FellowshipsThree members of the Biological Sciences Division faculty received fellowships from the John Simon GuggenheimFoundation, New York. They are: Dr.Frank W. Fitch (53), Professor ofPathology, for "Experimental Studies inCellular Immunology"; Robert Haselkorn, the Fanny L. Pritzker Professorand Chairman of Biophysics andTheoretical Biology, for "Metabolismand Biology of Blue Green Algae"; andPaul Sigler, Professor of Biophysics andTheoretical Biology, for" Studies in Protein Crystallography."luce ScholarshipJeffery C. Laurence, 21, a second yearstudent in The University of ChicagoPritzker School of Medicine, was one of15 students nationwide to be awarded aLuce Scholarship. He is enrolled in theUniversity in an M.S.-M.D. program.His field of study is microbiology.The 15 scholars selected will spendone year in East Asia. The program'saim is to "give participants a concentrated exposure to a specific Asian environment within the context of their professional interest." A stipend of $9,000plus international travel expenses will beprovided.Laurence, who graduated summa cumlaude from Columbia College, was alsorecently awarded a Rhodes Scholarship.Cancer controlThe University of Chicago has receiveda two-year grant for $276,750 from theNational Cancer Institute to plan acancer control program for the SouthSide of Chicago and the adjacent northwestern Indiana area. The grant, provides $135,000 in the first year and$141,750 in the second.Dr. John E. Ultmann and Dr. ChaseP. Kimball of The University of Chicagowill plan an "outreach" program underthe grant, which envisages planning foreducational and consultation programswith doctors and nurses in community hospitals and health facilities under provisions of the National Cancer Act of1971. Dr. Ultmann, Director of TheUniversity of Chicago Cancer ResearchCenter, is principal investigator of theprogram. He is also Professor in the Department of Medicine in the University'sDivision of the Biological Sciences andThe Pritzker School of Medicine and Director of Clinical Oncology in the Franklin McLean Memorial Research Institute. Dr. Kimball is Director of thePritzker School's Office of PostgraduateEducation, Chairman of the Committeeon Community Health Affairs of theUniversity's Hospitals and Clinics andAssociate Professor in the Departmentsof Psychiatry and Medicine.A Cancer Control Office will be set upunder a coordinator in the University'smedical complex to plan coordination ofactivities of the Division of the Biological Sciences, including the Hospitals andClinics, which pertain to education andconsultation in cancer detection andmanagement. It will build on efforts ofthe University Committee on Community Health Affairs, under Dr. Kimball,to plan for the University's involvementin community health activities. Theprogram would establish a graduatedsystem of health care from the primarylevel in the community to the advancedtreatment and research level in the University. Community hospital tumorboards would be developed to aid andtrain community physicians in the latestadvances in diagnosis and treatment ofcancer. Improved patient care programsand facilities would be considered, including motel accommodations for ambulatory patients receiving treatment atthe University, limited care facilities inor near the University, long-term management centers for terminally ill patients and rehabilitative programs.Community educational and public affairs projects would be considered, aswell as the planning and developing ofspecial radiological diagnostic procedures.Zak GrantRadovan H. Zak has received a threeyear research grant of $124,250 from theNational Heart and Lung Institute for astudy of the" Development and Regression of Cardiac Hypertrophy." In theinitial budget period, May 1, 1974 toApril 30, 1976, he will receive $80,727.In the second period, May 1, 1976 toApril 30, 1977, he will receive $43,523.Zak is Associate Professor in the Departments of Medicine and the FranklinMcLean Memorial Research Instituteand Research Associate in the Department of Biochemistry. The research involves investigationsof how the heart adapts to overloadssecondary to circulatory disease in animals and humans. The human studiesconcern diseased tissues obtainedthrough heart surgery. Funds will beused principally to pay research associates and fellows and to obtain supplies.Cancer of the PancreasThe University of Chicago has receiveda one-year U.S. government contractto study early diagnosis of cancer of thepancreas, which now ranks fourthamong U. S. cancers as a killer. The contract provides $175,000.Dr. A. R. Moossa, Assistant Professor in the Department of Surgery, isprincipal investigator in the study, whichwill be conducted cooperatively withsimilar programs at the Mayo Clinic andthe Sloan-Kettering Institute, NewYork. The contract is part of the effort ofThe University of Chicago Cancer Research Center program in the diagnosisand treatment of cancer. Under the National Cancer Act of 1971, cancer research centers established are expectedto develop interacting programs withother centers. Over 19,000 patients develop cancer of the pancreas each year inthe United States, said Dr. Moossa andthe incidence is increasing. The mortality rate is 90 per cent at the end of thefirst year after diagnosis. "It is obviousthat pancreatic carcinoma is diagnosedtoo late in the vast majority of cases" hesaid.Symptoms associated with pancreaticcancer are often non-specific, includingvague abdominal pain, weight loss, sudden onset of diabetes, especially if thereis no family history of diabetes, unexplained phlebitis and vague psychiatricsymptoms.Only occasionally, he said does atumor develop at a critical place to produce obstructive jaundice, by which thedisease may be more easily identified.Pancreatic cancer is usually diagnosedthrough exploratory surgery. Prior toundertaking laparotomies, said Dr.Moossa, patients who will be referred tothe University by other physicians, willundergo a variety of biochemical,radiological and nuclear medicine tests.The tests are time consuming, expensiveand difficult to do and require specialfacilities, he said.Patients over 35 with vague abdominalor systemic symptoms suggestive ofpancreatic cancer will be screened. If ahigh degree of suspicion is still present,they will be given various gastric juice,fiber optic, and peripheral blood tests.37Other tests will include pancreatic, liver,and spleen scans utilizingselenomethionine; ultrasonography todetect retroperitoneal tumors, selectivearteriography with magnification radiography; and selective injection of 99MTechnetium albumin microspheres intothe pancreatic vessels, followed byscanning. Exploratory laparotomies willfollow if the index of suspicion is stillhigh.Dr. Mossa has held preliminary sessions with cancer specialists at the MayoC1inic and the Sloan-Kettering Instituteto develop standardized data reportingprocedures for the project. Coinvestigators, with Dr. Moossa includeDr. David Skinner, Dr. Edwin Kaplan,Dr. Daniel Paloyan, Dr. George Block,and Dr. Richard Evans of the Department of Surgery; Dr. Paul Hoffer andDr. Phillip A. Collins, Radiology; Dr.Bernard Levin and Dr. Arthur Rubenstein, Medicine; and Dr. Charles Platzand Dr. Hyman Rochman, Pathology.Comprehensive Cancer Program UnderwayA comprehensive cancer center programis being developed in Chicago under theleadership of Dr. John Ultmann of TheUniversity of Chicago Cancer Center.This program was formed through thecooperation of eight Illinois medicalschools and several non-academic organizations influential in health carethroughout the city and state. Representatives of these organizations haveformed a non-profit corporation, the Illinois Cancer Council, with a board oftrustees.The individual organizations, incooperation with the Illinois CancerCouncil, will promote cancer diagnosis,research, and, education. They are:University of Chicago, PritzkerSchool of Medicine; NorthwesternUniversity Medical School; RushMedical School, RushPresbyterian St. Luke's MedicalCenter; University of Illinois, Abraham Lincoln School ofMedicine; Chicago MedicalSchool; Southern Illinois University School of Medicine; LoyolaUniversity Stritch School ofMedicine; Chicago College of Osteopathic Medicine; VeteransAdministration Hospitals; IllinoisDepartment of Public Health;American Cancer Society, IllinoisDivision, Inc. and Illinois StateMedical Society.It is one of 15 such center programsmandated by the National Cancer Act of1971. The other three ComprehensiveCancer Center Programs announced recently include:32 • The Yale University Medical SchoolComprehensive Cancer Center Program, New Haven, Connecticut• The Georgetown University--Howard University Comprehensive Cancer Program, Washington,D.C.• The Colorado Regional CancerCenter, Denver, Colorado, includingrepresentation from: University ofColorado, Denver and Boulder Colorado State University , Fort CollinsChildren's Hospital, DenverThe establishment of nine other programs was announced in 1973. All 13Center Programs, plus three which existed before passage of the 1971 Act,either meet now or soon will meet thespecial criteria set by the NationalCancer Advisory Board.Center programs are multidisciplinary, conducting cancer research anddemonstrating research findings that willbenefit patients. Each Center must develop outreach affiliations with otherhospitals and physicians in its are a tohelp them make available the latestmethods of cancer prevention, diagnosis, treatment and rehabiliation.The nine Comprehensive CancerCenter Programs identified last year arelocated at:• Children's Cancer Research Foundation, Boston• The Johns Hopkins Medical Institutions, Baltimore• Duke University Medical Center,Durham, North Carolina• University of Alabama School ofMedicine, Birmingham• University of Wisconsin MedicalCenter, Madison• Fred Hutchinson Cancer ResearchCenter affiliated with the Universityof Washington, Seattle• University of Southern California(with the Los Angeles County Department of Hospitals), Los Angeles• University of Miami School ofMedicine, Miami• The Mayo Foundation, Rochester,MinnesotaThe three pre-existing ComprehensiveCenters are:• The M. D. Anderson Hospital andTumor Institute, Houston• Memorial Sloan-Kettering CancerCenter, New York• Roswell Park Memorial Institute,BuffaloEmergency Medicine GrowsThe University of Chicago this year received over 200 applications for eightfirst-year 1974-75 residencies inemergency medicine. In July, its first group of residents in this new medicalspecialty entered their last year in thetwo-year program and the new group ofeight joined them, bringing theemergency medicine training program todouble its present strength. At the sametime, the program's director, Dr. PeterRosen, added two more faculty membersto the present teaching staff of four.Dr. Rosen is Professor in the divisionof emergency medicine at theUniversity's Pritzker School ofMedicine and Director of the adultemergency department at theUniversity's Hospitals and Clinics. Dr.Joseph B. Kirsner, Chief of Staff of TheUniversity of Chicago Hospitals andClinics and Deputy Dean for MedicalAffairs in the Pritzker School, sees anurgent need to train more physicians tohandle emergency problems, Patient visits to hospital emergency rooms are upall over the country, he said and havegrown at more than an average rate atThe University of Chicago. The adultand children's emergency rooms at TheUniversity have about 330 patient visitsper day, which ranks them as one of thebusiest emergency services in the state,according to Dr. Kirsner.Patterns of emergency departmentmedical care are drastically changing,said Dr. Rosen, with a vast discrepancybetween the number of patients appearing and the physicians available. Notmany physicians are specifically trainedfor emergency medicine, Dr. Rosensaid. Other than actually working fulltime in an emergency department, therewas, until recently, no way to learnemergency medicine. "I wouldn't want asurgeon without training in surgery tooperate on me. The field of traumalikewise requires special aptitudes andtraining-more than just several monthsin a revolving internship."Beyond the need for emergency roomstaffing, entire hospitals need night-timestaffing with experts in trauma, he said."If you have a night-time emergency in ahospital that has no night-time specialistsin house, you are risking your life." Insome small hospitals, it is not uncommonto find no physician on night-time duty,he said. In others, staff specialists suchas dermatologists, psychiatrists, and allergists may take turns at night duty."They may not be temperamentally orprofessionally capable of handlingemergencies. "The University is looking for specialtraits in candidates for its emergencymedicine residencies. In addition tocompletion of the normal first-year postgraduate medical training after the M.D.(internship), they must have good judgment and be fast at making crucial deci-sions on minimal information, Dr.Rosen, said. "Frequently, theemergency room physician has neverseen the patient before. He must recognize the need for and then be willing tointervene actively in life-threateningmedical problems. Some physicians dothis well. They are fairly aggressive andtake an approach like that of a surgeon."Positions for which a residency inemergency medicine might qualify acandidate include director of emergencymedicine at other universities institutingsuch a training program, director ofemergency medicine in community hospitals and planning positions in publichealth agencies or other governmentagencies. Dr. Rosen sees "virtually anycareer open" for specialists inemergency medicine. It is one of the fewmedical specialties that is not overcrowded in large, urban areas, he said.The University of Chicago was one ofthe first institutions in the United Statesto have an emergency medicine residency program. There are now about 15medical centers with such programs. Dr.Rosen foresees a program that in the future will also include training ofparamedical personnel. "A whole areain emergency medicine needs to be developed, such as delivery of care in theambulance before the patient arrives atthe hospital." He would accomplish thisthrough upgrading the level of training ofambulance attendants."As people find access to doctors intoday's cities more difficult, everyemergency department in the country isseeing more and more non-emergencycases." A true emergency is defined byDr. Rosen as "a threat to life or limb."However, he said, this is a "doctordefinition, not a patient definition. To apatient, an emergency is an acute problem that he has a fear about, rangingfrom a heart attack to a sore throat."Conventional facilities such as primarycare ambulatory centers normally function only in the day time, which meansthe non-emergency cases will continueto appear in the ER at night. "Patientswant access to doctors 24 hours a day,365 days a year," Dr. Rosen said.Drugs-Not for Emergency RoomLong-acting tranquilizers such asphenothiazine used with hysterical orviolent psychiatric patients in hospitalemergency departments interfere withsubsequent proper treatment and diagnosis by psychiatrists, said Dr. Beverly, Joyce Fauman, a University of Chicagopsychiatrist. Treatment should consist of"identifying the crisis, establishing controls and converting the patient's be- havior from physical actions to words,"she told the Illinois Section of theAmerican College of EmergencyMedicine April 19."Physical restraint has minimalhazards when applied with firmness inadequate amounts and for control ratherthan for punishment." If circumstancesreally do not allow adequate physical restraint, the last step should be to giverapid-onset, short-acting sedatives suchas amobarbital, which permit thepsychiatrist to communicate with the patient within one hour."Dr. Fauman, instructor in psychiatryand a member of the faculty of theUniversity'S emergency medicine group,said long-acting tranquilizers may alsohave unfortunate side-effects such ashypotension and cardiac irregularities."Unfortunate as well is the striking success of their sedative action, which oftenrenders the patient uncommunicative forthe next four to twelve hours, and mayhinder diagnosis for one or two days."Drugging a patient may conceal an organic brain syndrome, said Dr. Faumanand make the patient "even more disoriented and hence more frightened andout of control." The suicidal patient, likeother psychiatric patients, has let go ofcontrol of his life, and the emergencyphysician is called upon to take control.Bargaining or promising should beavoided. The physician implies by thisthat he is not sure who is in charge. If thephysician allows the patient to manipulate him, the patient will feel even moreout of control. "Psychiatric patients are frightened atthe loss of self-control, and welcome thephysicians' reestablishment of controls,she said. "The physician need not hesitate to be direct, open, to ask directlyabout suicidal thoughts, about homicidalintents, and about fears. "There is practically nothing you can say that willmake the patient worse. Address hishealthy side, make efforts to help himobserve himself, tell him what you aredoing and why you are doing it; don'tbargain, lie, or imply promises that youcan't fulfill. Use medication only as alast resort."Dr. Fauman spoke at the Collegesponsored three-day meeting, April18-20 in the Ambassador West Hotel.The meeting was co-sponsored by TheUniversity of Chicago's emergencymedicine faculty group.Rowley FindingsSpecific cancer-producing agents causespecific chromosome abnormalities inleukemia and other human tumors. Thishypothesis is presented by a University of Chicago cytogeneticist, Dr. Janet D.Rowley, ('49) in the February Journal ofthe N ational Cancer Institute. Dr.Rowley's theory questions the traditional belief among life-scientists that thewide variety of chromosomal abnormalities in various types of leukemiahave no relationship to the basicleukemic process. She says that, on thecontrary, consistent chromosomal abnormalities now being discovered mayultimately clarify the mechanisms responsible for leukemias and other cancers.Her theory is based on new evidenceacquired by herself and others since newmicroscopic techniques were introducedin 1970. These new Giemsa staining andquinacrine f'lourescence techniquesmake it possible, for the first time, toidentify all the individual chromosomes,their normal composition, and abnormalities in their "band" pattern. "Inmost acute leukemias," she said, "thechromosome pattern has appeared to bevery variable. They may have abnormalnumbers of chromosomes ranging fromless than 45 up to 51 or 52 or more. Untilrecently, the patterns all seemed to bedifferent. Scientists just dismissed thechromosome abnormalities as representing merely an epiphenomenon-havingnothing to do with the basic leukemicprocess."But now when you look at cells fromthese patients with the new stainingtechniques, you can see some consistentchanges. In addition, of course, there aresome variable or random chromosomechanges that are superimposed and thatare different from one patient toanother. "The major exception to the variablekaryotype in leukemia until recently hasbeen the association of a specificchromosome abnormality with chronicmyelogenous leukemia (CML), one typeof leukemia. In 1960, two Philadelphiainvestigators showed that people withCML consistently lacked the long arm ofone chromosome No. 22 (22q-). Lastyear, Dr. Rowley presented evidencethat the missing 22q material had translocated (moved over) to chromosomeNo.9 (9q+). This phenomenon has beentermed the Chicago translocation of thePhiladelphia chromosome.Dr. Rowley now has new evidence ofconsistent chromosomal abnormalities inanother type of leukemia, acutemyelogenous leukemia (AML). There issome chromosomal variability in AML,she notes, but she reports markedsimilarities in abnormal cells from threerecent patients. Cells from two of themhad an identical complex karyotype (visual, classified array of chromosome33types arranged from photomicrograph).A third patient with a similar abnormality has since been discovered. Cells fromall three patients had 45 chromosomes,versus the normal 46, and were lackingthe X chromosome. In addition, onechromosome No.8 had a break in thelong arm in the same location in all threepatients. A portion of the long arm of thebroken No.8 chromosome was translocated to one No. 21 in two patients andto the long arm of No. 17 in the third.This may indicate that there are certain"hot spots" in human chromosomes-locations where chromosomes aremore likely to break than others, Dr.Rowley says."This finding provides preliminarysupport for the suggestion thatchromosomal abnormalities in this disease may not be entirely random." Inaddition, she notes, consistent chromosome abnormalities have been found byothers in meningioma, a tumor of nervetissue, and in Burkitt's lymphoma. Insome patients with apparently variablechromosomal patterns, other consistentabnormalities were found. These included patients with polycythemia rubravera (PY), a disorder characterized byexcessive red blood cells. In support ofher theory, Dr. Rowley cites recent experiments which demonstrate specificchromosomal abnormalities induced bycancer-causing chemicals and viruses inanimals and in human and animal tissueculture.Dr. Rowley is Associate Professor inthe Department of Medicine (Hematology) and in the Franklin McLeanMemorial Research Institute at the University. The Institute is operated by theUniversity under a contract with theU.S. Atomic Energy Commission.Fiber Deficiency ConfabThe University of Chicago sponsored aconference on Fiber Deficiency Disorders of the Colon at The Center for Continuing Education, May 17. The programfeatured leading specialists in diet, colonic function, and disorders of the colonfrom Great Britain, Canada and the United States.Dr. Richard W. Reilly, (53) AssociateProfessor in the Department ofMedicine (Gastroenterology), coordinated the effort.Other University of Chicago participants were:-Dietary Fiber and Interaction withBacteria and Bile, Dr. Irwin H. Rosenberg Co-Chairman.-Fiber and Colonic Function, Dr.Charles S. Winans, Chairman.-"Fiber Deficiency and the Irritable34 Colon Syndrome," Dr. Joseph B. Kirsner, Discussant.-General Discussion, Dr. Kirsner andDr. Reilly, Chairman.The University of Chicago participants are from the Gastroenterology Section of the Department of Medicine, ofwhich Dr. Rosenberg is Chief.Cystic Fibrosis CampaignDr. Karl J. Fritz, (71) vice president incharge of programs and member of theexecutive committee of the NorthernIllinois Chapter of the National CysticFibrosis Research Foundation, announced the annual Breath of Life fundraising campaign August 17 to August25.The Foundation's local programs include an annual summer camp for cysticfibrosis, victims.The organization sponsored researchby University scientists including Dr.Albert Dorfman of the Department ofPediatrics on the genetic defect responsible for cystic fibrosis.Dr. Fritz, is stiown with Chuck Tanner, ChicagoWhite Sox lV1anager and the 1974 Breath of LifeCampaign Chairman and Doug Broehl, thechapter's 1974 Poster Child. Fund Raising Campaign launchedThe University of Chicago officiallylaunched its campaign June 17 to raise$280,000,000 in new endowment, operating and building funds. Most of theamount to be earmarked for new buildings and facilities-$50,000,000-is to goto the medical area and the biologicalsciences. More than $24,000,000 of thisamount has already been raised in a special campaign which was started earlier.Almost half the total campaign sum isfor endowment. This includes$54,500,000 for professorships;$69,700,000 for support of educationalprograms and $13,500,000 for studentaid. $59,015,000 is being sought whichthe University can spend on currentprograms; this includes $5,000,000 forstudent aid, $22,515,000 for academicprograms and $31,509,999 in unrestrictedfunds. $64,000,000 has already beenraised from foundations, individualdonors, companies, and among the Trustees, to begin the drive. The Trusteeshave set a goal of $28,000,000 for theirown contributions to the University during the campaign, which is expected tolast from three to five years.In this campaign, the University isstressing funds which will provide support for the long-term faculty positions,student aid, research in the sciences, andnew academic programs in the College,the graduate divisions, and some of theprofessional schools.Edward H. Levi, President of theUniversity, said the University has beenable to continue to attract the most eminent scholars to the faculty in recentyears despite severe budgetary constraints. To guarantee that the University would have the means to maintain itsexcellence, the Trustees, in the last several years, have approved budgets withshortfalls in them between income andexpenditures. The size of the faculty hasbeen reduced by about 100 during thisperiod, to its present level of 1,077 andthe size of the student body has remained at about 7,500 to rise to 7,600next year. Further, the University hasimproved its ranking in memberships insuch learned societies as the NationalAcademy of Sciences, the AmericanAcademy of Arts and Sciences, and theAmerican Philosophical Society. It nowstands among the top four institutions inall of them. And a recent survey indicates that it ranks second in the baccalaureate origins of members of the National Academy of Sciences."Clearly, the University is verystrong," Gaylord Donnelley, Chairmanof the Board of Trustees said. "Yet it isonly 8th in the size of its endowment andwe know it cannot go on over-achievingforever. Now is the time to give it thedeeper financial foundation it obviouslyneeds, and to supply the funds needed tomake some new achievements in research, education and teaching that weknow are possible here." In severalyears of planning, the underlying consideration had been a determination tostrengthen the University. The budgethas been held constant or reduced in recent years. The University's budget for1974-75 has been trimmed by $2 million.Further cuts in later years could endanger the quality of parts of the institution.The preeminence of the University ofChicago in the world of education and ofresearch is recognized everywhere,Donnelley said. He pointed out that 38percent of its 80,000 living alumni are ineducation, 27 percent of them in highereducation, and that more than 140 presidents of other institutions of learning areits graduates. In the Big Ten universities, nearly 1,000 members of the faculties hold degrees from Chicago. Thesefigures, along with the University's historic relationships with leading privateinstitutions in the Midwest and with themajor state universities in this region,give the University of Chicago a specialimportance in this area, Donnelley said.Its strength is vital to this entire networkof relationships and to the other institutions. It has been important in the development over the years of ArgonneNational Laboratory, which the University manages under contract for theAtomic Energy Commission through atripartite arrangement with the AEC andthe Argonne Universities Association,as well as to the location here of the Enrico Fermi Accelerator Laboratory insuburban Batavia.Finally, he noted that the Universityof Chicago in the 1950s had placed itsstrength and expertise, and $30 million infunds, behind the efforts to renew theHyde Park-Kenwood neighborhood andstabilize it; that effort was successful,resulting in a stable integrated neighborhood that is nationally recognized. Donnelley said the Trustees' commitment tosupport that stability continues now.In MemoriamRay BrownRay Everett Brown, 60, formerly VicePresident for Administration of TheUniversity of Chicago, died Saturday,May 4, at his home. He suffered a coronary attack several weeks earlier. At thetime of his death, he was executive vice president of Northwestern University'SMcGaw Medical Center.Mr. Brown's direct association withThe University of Chicago as student,teacher, and administrator, spanned theperiod 1942 to 1964, and he continued toserve the University as lecturer, adviser,and active alumnus until his death.In 1942, he entered The University ofChicago's Graduate School of Businessas a student of hospital administration.He received his M.B.A. degree and wasnamed to the faculty of the School in1945 as Associate Professor of HospitalAdministration; in 1953 he became a fullprofessor. He was named Superintendent of The University of Chicago Hospitals and Clinics in 1946; the followingyear he was named Associate Directorof the Graduate Program in HospitalAdministration and in 1953 he becamethe program's Director, holding the postuntil his appointment as University VicePresident in 1961.Ray BrownDr. Leon O. Jacobson, said:"To speak of my friend Ray Brown, isto give testimony to the respect and highregard in which this man is held acrossthe nation and the world. We were allRay's students, because his classroom had no walls. No problem to him wasinsoluble because he would find the elusive answers that others never visualized. As a leader, he established apattern of excellence in research, teaching and hospital administration."Mr. Brown was past President of theAmerican Hospital Association, theAmerican College of Hospital Administrators, the Illinois Hospital Association, and the Chicago Hospital Council.He received the Distinguished ServiceAward of the Illinois Association in1962. He was a member of the NationalJoint Commission for Accreditation ofHospitals, the National Joint Council toImprove Health Care of the Aged, theNational Advisory Committee on Medicare, and the Advisory Committee onHospital Administration CounselingServices of the American Hospital Association.Memorial services were held May 8.Friends who wish to honor him maymake contributions to either the Ray E.Brown Management Collection of theAmerican Hospital Association Library,or the Ray E. Brown Hospital Administration Fellowship at The University ofChicago's Graduate School of Business.Contributions to the latter may be madeto the Hospital Administration Program,5720 South Woodlawn, Chicago, Illinois60637.Dr. Ralph W. GerardDr. Ralph Waldo Gerard, internationally known physiologist of the centralnervous system, died February 17 inNewport Beach, California. He was 73.A native of Harvey, Illinois, Dr. Gerardearned his B.S. and Ph.D. degrees fromThe University of Chicago in 1919 and1921, respectively. He received an M.D.degree in 1924 from Rush Medical College (Chicago).Dr. Gerard joined The University ofChicago faculty in 1927 as an AssistantProfessor of Physiology. He became anAssociate Professor in 1929 and a Professor in 1942. During his years at theUniversity he conducted extensive research in neurochemistry, electrophysiology, and medicine.Specifically, he did pioneering work onchemical and electrical activity in thebrain and nervous system. He producedmore than 750 articles and nine books.about half of which were published during his University of Chicago years. Hisfavorite book, which appeared in 1940,was Unresting Cells and it is still used asa reference work for biology courses. Inthe late 1920's he helped develop andteach the first comprehensive course in35biological science. This became a requirement for all students at the University, regardless of their field. Such basiccourses have been introduced now onmany other university campuses.In the 1930's Dr. Gerard commutedfrequently between Chicago andWashington, acting as a consultant to theDepartment of Defense, the NationalInstitute of Mental Health and othergovernmental agencies. From 1952 to1955 he was a professor of neurophysiology and physiology and director oflaboratories at the Neuropsychiatric Institute of the University of Illinois Medical School.The University of Chicago appointedDr. Gerard a Professor of BehavioralScience early in 1955. This was perhapsthe first such appointment in the worldand reflected the growing professionalconviction that science and thehumanities would have to join to solvemajor social issues. In the fall of 1955,Dr. Gerard helped found the MentalHealth Research Institute at the University of Michigan, becoming director oflaboratories and professor ofneurophysiology on the Ann Arborcampus. In the same year he was electedto the National Academy of Sciencesand to the American Academy of Artsand Sciences. Between 1958 and 1964Dr. Gerard focused his research onschizophrenia. He published a majorpaper of interdisciplinary research on theclassification of the disorder. He alsopublished early evidence that schizophrenia might be caused by faulty bodychemistry, challenging Freudian theory.In 1964, Dr. Gerard was invited tohelp found the University of Californiaat Irvine. He served there as the firstdean of the graduate division and a professor of biology. He became a professoremeritus in 1970. During his long career,Dr. Gerard served on the faculty of theUniversity of South Dakota and received honorary degrees from the Universities of Maryland, Leiden (Holland),St. Andrews (Scotland), and Brown andMcGill Universities. He received theAlumni Medal of The University ofChicago Alumni Association in 1967 andwas named an Honorary Fellow of theRoyal Society of Edinburgh in 1968.He is survived by his wife, the formerLeona Bachrach, and son James. Mrs.Gerard was graduated Phi Beta Kappaand magna cum laude from The University of Chicago with a bachelor's degreein 1920.Alumni Deaths'04. Ernest C. Mc Kibben , Seattle,Washington, March 20, 1974, age 95.36 '10. Frederick H. Falls, Red Wing,Minnesota, February 8, 1974, age 88., 13. George W. Dunlap, Toledo,Ohio, December 2, 1972, age 88.'13. CarlO. Rinder, Oak Park, Illinois, April 11, 1974, age 84.'14. Gleason C. Lake, Grosse PointeFarm, Michigan, October 28, 1973, age91.'14. Russell O. Wharton, CrownPoint, Indiana, November 6, 1973, age85., 16. Raymond O. Dart, Washington,D.C., February 2, 1974, age 84.'18. Pierce Mac Kenrie, Evansville,Indiana, February 5, 1974, age 81.'21. R. Esmond Smith, Los Angeles,California, September 16, 1973, age 83.'22. Frank S. L. Newcomb, Pasadena,California, March 17, 1974, age 82.'23. Joseph E. Allegretti, RiverForest, Illinois, March 5, 1974, age 72.'23. Knowlton E. Barber, Evanston,Illinois, April 11, 1974, age 72.'23. Adolph M. Hansen, Los Angeles,California, May 10, 1974, age 78.'24. Edwin J. Blonder, Skokie, Illinois, January 23, 1974, age 73.'24. Cornelius N. Vet t en ,Guilderland, New York, October 13,1972, age 73.'25. Ralph W. Gerard, Corona DelMar, California, February 17, 1974, age74.'25. Morris H. Jones, Jr., Oak Park,Illinois, February 27, 1974, age 74.'25. Harold D. Lillibridge, Olympia,Washington, April II, 1974, age 77.'26. Frank K. Power, Salem, Oregon,October 25, 1973, age 71.'27. Edmund W. McElligot, San Jose,California, December 17, 1969, age 71.'28. Mead Burke, Madison, Wisconsin, October 4, 1973, age 79.'28. Arthur E. Diggs, Evanston, Illinois, April 15, 1974, age 76.'28. Arthur H. Klawans, Chicago, Illinois, September 8, 1973, age 71.'29. Raymond V. Jolin, Vista,California, March 29, 1974, age 72.'29. Robert M. Muirhead, Salt LakeCity, Utah, March 11, 1974, age 74."31. William G. Rurik, Park Ridge, Illinois, December 17, 1973, age 68.'31. A. Dougal Young, Baltimore,Maryland, January 3, 1974, age 70.'32. Matthew M. Lewison, Chicago,Illinois, February 15, 1974, age 67.'32. Paul F. Olson, North Hollywood,California, November 1973, age 68.'33. William E. Barry, Philadelphia,Pennsylvania, October 30, 1973, age 69.'36. John P. Darling, Lakeland,Florida, December 19, 1973, age 64.'36. Andrew J. Niehaus, Wheeling,West Virginia, May 7, 1973, age 65.'38. William H. Blank, Fort Lauder- dale, Florida, August 23, 1973, age 71.. '39. Louis A. Sass, Oak Lawn, Illinois, May 15, 1974, age 60.'40. Raiford D. Baxley, Wagram,North Carolina, June 6, 1971, age 54.'42. Edward A. Evans, Salt Lake City,Utah, February 18, 1974, age 58.'42. Alexander D. Leschuck, Harvard,Illinois, June 24, 1972, age 57.'42. Francis L. Rook, San Diego,California, December 25, 1973, age 58.'53. John B. Harris, Larkspur,California, October 16, 1973, age 48.'54. Jay L. Collins, Windsor, Ontario,Canada, December 20, 1973, age 51.'61. John R. Green, Seattle,Washington, April 8, 1974, age 42.Former StaffKenneth M. Barton (Medicine, Assistant and Trainee, 61-63; Instructor andFellow, 63-64), San Francisco, California, June 11, 1973, age 43.Daniel S� De-Stio (Surgery-Otolaryngology, Intern, 31-32),Pittsburgh, Pennsylvania, August 13,1973, age 67.Carl H. Jo h ner (Surgery-Otolaryngology, Resident, 63-64; Instructor and Assistant Professor, 64-68),Glencoe, Illinois, March 11, 1974, age40.David H. Johnson (Obstetrics andGynecology, Resident, 22), Tacoma,Washington, December 12, 1973, age 81.Norbert Lewinson (Student HealthClinic, Physician, 51-55), Chicago, Illinois, April 17, 1974, age 75.Kurt W. Newgard (Obstetrics andGynecology, Resident, 36-37), SanFrancisco, California, September 1973,age 65.Ethelbert Spurrier (Surgery, Resident,27-28), Grosse Ponte, Michigan, July25, 1973, age 74.Departmental NewsAnatomyAppointments: Eileen Kane, Ph.D.-Assistant Professor.Francis Manasek-Associate Professor.Richard Wassersug, Ph. D. (73)-Assistant Professor.Dr. Charles E. Oxnard, Professor inAnatomy, Anthropology, the Committee on Evolutionary Biology, in the College and Dean of the College, has coauthored" "Some Locomotor Featuresof the Pelvic Girdle in Primates," and"Some Locomotor Adaptations amongLower Primates: Implications for Primate Evolution," in Grafton ElliotSmith and the Concepts of HumanEvolution, Lord Zuckerman, ed.,Academic Press, 1974. Dr. Oxnard wasappointed associate editor of the American Journal of Physical Anthropology.He chaired the session on primate biology and presented a paper on "PrimateStructure and Locomotion" at the meeting of the American Association of Physical Anthropology April 11-14.Dr. Ronald Singer, Robert R. BensleyProfessor in Biology and Medical Sciences, Anatomy, Anthropology, theCommittees on Evolutionary Biologyand Genetics, and in the College, hasbeen named principal investigator for a12-month Natural Science Foundationproject: "Excavations at Hoxne." Thegrant is $35,000.AnesthesiologyDr. James O. Elam, Professor in Anesthesiology and Obstetrics and Gynecology, helped supervise production of"Airway Obstruction" (in emergencypatients), a sound-color film produced byHealth Research, Inc. It will be distributed by American Film Productions,New York.Ben May laboratoryPromotion: Dr. Eugene DeSornbre-Associate Professor.Joseph Fried, Ph. D., the Louis BlockProfessor in the Departments ofChemistry and Biochemistry and in theBen May Laboratory, delivered theBurger Lecture at the University of Virginia, April 19, on "Prostaglandins:Synthesis and Biological Properties."The Burger Lecture is the major annuallecture sponsored by the University ofVirginia's Department of Chemistry andwas named in honor of Professor AlfredBurger. Professor Fried was chosen bythe Division of the American ChemicalSociety Medicinal Chemistry to be therecipient of the Medicinal ChemistryAward. This award is given every second year. Professor Fried is the fifth recipient. The award consists of a plaqueand a $1,000 honorarium.Dr. Charles B. Huggins will deliverthe I. S. Ravdin Lecture in the BasicSciences at the 1974 Clinical Congress ofthe American College of Surgeons inMiami Beach, October 23. Dr. Huggins,is the William B. Ogden DistinguishedService Professor in the Ben MayLaboratory and the Department ofSurgery. He published "HormoneDependent Stem-Cell Rat Leukemia Joseph FriedEvoked by a Series of Feedings of7,12- Dimethylbenz-(a)anthracene" inthe April, 1974 Journal of the NationalCancer Institute. It was co-authored byDr. Hiroki Yoshida, the Charles DeereWiman Fellow in the Ben May Laboratory and Dr. Cohn C. Bird, formerpost-doctoral fellow.A. Haridara Reddi, Assistant Professor in the Ben May Laboratory, is theprincipal author (with Dr. Huggins asco-author) of "Cyclic ElectrochemicalInactivation and Restoration of Competence of Bone Matrix to TransformFibroblasts." The report appears in theMay, 1974 Proceedings of the NationalAcademy of Sciences.BiochemistryThe following 16 members of the Department of Biochemistry presentedpapers at the Biochemistry-Biophysics1974 meeting of the Federation ofAmerican Societies for ExperimentalBiology, June 2-7 in Minneapolis:Nicholas Cozzarelli, Glyn Dawson, Dr.Albert Dorfman, (44) Wolfgang Epstein,Robert Haselkorn, Robert Heinrikson,Ferenc Kezdy, Dr. Ramon Lim, MartinMathews, T. Nakamoto, Dr. AngeloScanu, Dr. Theodore Steck, Allen Stoolmiller, Dr. Donald Steiner (56),Marguerite Volini, and Samuel Weiss.Emil T. Kaiser, Professor in the Departments of Chemistry, Biochemistryand the College, and Ferenc J. Kezdy,Professor in the Department ofBiochemistry, are coeditors of Progressin Bioorganic Chemistry, Volume 2.Dr. Ira J. Wool (53), A. J. CarlsonProfessor in Biochemistry, and Frank A.Ventimiglia published an article on "AKinase that Transfers the GammaPhosphyryl Group of GTP to Proteinsof Eukaryotic 40S Ribosomal Subunits,"in the February Proceedings of the National Academy of Sciences.BiologyPromotion:Rochelle Esposito, Ph. D.-to AssociateProfessor in the Department of Biologyand in the College.George W. Beadle, PresidentEmeritus and Honorary Trustee andWilliam E. Wrather Distinguished Service Professor, was named an honorarymember of the Illinois State Academy ofScience.The work of Aron A. Moscona,Ph.D., the Louis Block Professor in theDepartments of Biology and Pathology,and Chairman of the Committee on Developmental Biology, was reported inthe May issue of La Recherche, Paris.Entitled, "Comment les cellules embryonnaires se reconnaissent entreelles," the article reported on experiments by Moscona and his associates.Their work proves the exsistence of a"recognition" factor by which dissociated, like embryonic cells mutuallyidentify each other and aggregate to forminto specialized tissue. Dr. Mosconachaired a session on Cell Interaction atthe International Embryological Conference in Sorrento, Italy April 1-6, andlectured at the Max-Planck Institute,April 8 on "Molecular Mechanisms ofCell Aggregation." He has been electeda member of the board of the International Society of DevelopmentBiologists.Thomas Park, Ph.D., Professor inBiology and the Committee on Evolutionary Biology is one the authors of"The Cannibalism of Eggs by TriboliumLarvae," in Physiological Zoology,January, 1974. Professor Park is theeditor of Physiological Zoology. He isadministrator of a Ford Foundationgrant amounting to approximately$52,000 for Predoctoral Fellowships inPopulation Biology for 1974-75.Biophysics and Theoretical BiologyPromotion:Hugh P. Wilson-to Assistant Professor.37Divisional GeneralDr. Peter Rosen, Professor ofEmergency Medicine and Director ofthe Adult Emergency Services at Billings Hospital, will lecture on "Physicians' Assistants in Health CareFacilities" at the American Health Congress, McCormick Place, August 13.Dr. Marshall B. Segal, Associate Professor of Emergency Medicine, and a fellow of the American Academy of Forensic Sciences, has been elected a memberof its council and Secretary of theAcademy's general section. Dr. Segalhas a J.D. degree and is a member of theBoard of Governors of the AmericanCollege of Legal Medicine.MedicinePromotions:Dr. Arthur Rubenstein-to Professor.Dr. John L. Skosey (61)-to Associate Professor.Dr. Thomas A. Stockert (62)-to Assistant Professor.Dr. Nicholas J. Lenn (64), AssistantProfessor in Pediatrics and Medicine(Neurology), served as a visiting facultymember at the Mayo Clinic, February15-16. Dr. Lenn presented two seminarson Pediatric Neurology: "Synaptologyof the Interpeduncular Nucleus," and"Late Infantile Cerebral Lipidoses."Murray Rabinowitz (left)Dr. Murray Rabinowitz, Louis BlockProfessor in the Departments ofMedicine and Biochemistry, was visitinglecturer .at the Cardiovascular ResearchInstitute of the University of California,San Francisco, April 22-23. The title ofhis seminar was "Synthesis and Turnover of Myocardial Components of theNormal and Hypertrophied Heart." Dr.38 Rabinowitz will be moderator of a Symposium on Cardiac Hypertrophy for theWorld Congress of Cardiology, to beheld in Buenos Aires, Argentina, September 1-17.Dr. Rabinowitz and Hewson H.Swift, Ph.D. have been named principalinvestigators for a two-year study,"Analysis of the Mitochondrial Genomein Yeast." The National Science Foundation has allotted $50,000 to this inquiry. Professor Swift is the Distinguished Service Professor in Biology,Pathology, the College, and the Committee on Genetics, and is Chairman of theDepartment of Biology.Hewson SwiftDr. John W. Rippon is the principalinvestigator of a $15,695 grant from theIllinois Division of the American Cancer Society to study "Opportunistic Fungous Infections in Patients with Neoplastic Diseases: Diagnosis by Detectionof Antigen in Serum." Dr. Rippon is anAssociate Professor in Medicine (Dermatology) and a Research Associate inMicrobiology and in Biology.Dr. Janet Rowley, (49), AssociateProfessor in Medicine, the FranklinMcLean Memorial Research Institute,and the Committee on Genetics, wasnamed the Caroline Standish MemorialLecturer for 1974 at the University ofPittsburgh Medical School. At the lecture on May 20, she discussed her recentresearch on chromosome defects inleukemia.Dr. John E. Ultmann, Professor in theDepartment of Medicine and the Franklin McLean Memorial Research Institute, and Director of the Cancer Research Center, attended the First Venezuelan Congress of Internal Medicinein Caracas, May 12-18, as one of fourinvited foreign guests. He spoke on"Non-Hodgkiri's Lymphomas: CurrentApproaches" and attended a round-tablewith Venezuelan experts on the sametopic. He also gave a seminar on"Methods of Teaching Hematology" tothe Society of Hematology of Venezuela. February 6, Dr. Ultmanntestified before the House Subcommitteeon Public Health and Environment ofthe U. S. Congress on a bill to improvecancer research; March 18-20 he discussed "Endocrine Manifestation of Nonendocrine Tumors," "Chemotherapy ofBreast Cancer," "Current Concepts onManagement of Lymphoma" and"Thrombotic Thrombocytopenic Purpura," at the Dallas Southern ClinicalSociety meeting.Dr. Nicholas A. Vick (65), AssistantProfessor in Medicine (Neurology) presented a paper on "Gliomas Induced byAvian Sarcoma Virus (ASV); Early andSequential Structural Events of theNeoplastic Transformation in Vivo" atthe 50th annual meeting of the AmericanAssociation of Neuropathologists inBoston, June 8.Dr. Charles S. Winans, Assistant Professor in Medicine, is the author of"Esophageal Determinants ofAlaryngeal Speech," in Archives ofOtolaryngology, January, 1974.Dr. Radovan Zak, Associate Professor in the Department of Medicine andResearch Associate in Biochemistry,spoke at the Symposium of the EuropeanGroup for Research in HeartMetabolism, held in Prague, Czechoslovakia, June 12. The title of his lecturewas "Critical Evaluation of the Use ofRadioactive Tracers in Biological Experiments." Dr. Zak spoke at the Univer-sity of Coimbra, in Coimbra, PortugalJuly 29 on "Development and Proliferative Capacity of Cardiac Muscle Cell."He will also participate in the WorldCongress of Cardiology in Buenos Airesin September. His talk will be on "Regression of Cardiac Hypertrophy."MicrobiologyAppointments:Patricia Spear, Ph.D. (69)-AssistantProfessor.James Shapiro, Ph.D.-AssistantProfessor.Dr. Eugene N. Fox, Associate Professor in LaRabida and Research Associate in Microbiology, reported at apress conference in Chicago May 14 thata vaccine for respiratory strep infectionsproved effective when sprayed into thenostrils of patients. Testing proceduresfor safety will still require a number ofyears. The work on the vaccine was performed by a University of Chicago-University of Florida medical team.Bernard Roizman, Ph.D., Professorin the Departments of Microbiology andBiophysics and Theoretical Biology, andthe Committees on Genetics and Virology, delivered the annual Harry ShayMemorial Lecture at Temple University, March 21.Obstetrics and GynecologyDr. Marshall Lindheimer, AssociateProfessor in the Departments of Obstetrics and Gynecology and Medicine, waselected to Associate Fellowship in theAmerican College of Obstetricians andGynecologists. Dr. Lindheimer is aspecialist in renal disease and physiologyand is one of the few internists to receivethis honor. In recognition of his researchin obstetrics, Dr. Lindheimer has beenelected to the Council on High BloodPressure Research Medical AdvisoryBoard of the American Heart Association.Dr. Michael Newton is returning on afull-time basis as Professor and Chief ofthe Oncology Section. He has been associated with the Department on a parttime basis since 1966, during which timehe was Director of the American Collegeof Obstetricians and Gynecologists. Heis on the international editorial board ofExcerpta Medica and the editorial boardof the Journal of Obstetric, Gynecologicand Neonatal Nursing, and is a consulting editor ofthelournal of ReproductiveMedicine.Dr. Gebhard F. B. Schumacher, Professor in the Department and Chief ofthe Reporductive Biology Section, wasinvited to serve as an observer for theProgram for Applied Research in Fertility Regulation of the Agency for Interna- tional Development (AID) at theSeventh Karolinska Symposium, held inGeneva, Switzerland at the headquartersof the World Health Organization, July29-31. The Symposia are closed meetings at which 20 papers are presented byinvited speakers and are discussed by asmall group of invited participants. Thetopic of the Symposium is "Immunological Approaches to Fertility Control."He also is serving as a consultant to the"Deutsche Forschungsgemeinschaft,"the West German Science Foundation,for the planning of a meeting on Research in Reproductive Medicine to beheld July 11-13, 1974, in Bonn, WestGermany.Dr. Schumacher delivered lectures on"Cervical Factors in Infertility" and"Proteinase Inhibitors in Human Cervical Mucus and their in vitro Interactionwith Acrosin, an Acrosomal Proteinaseof Human Spermatozoa" at the 22nd annual meeting of the American College ofObstetricians and Gynecologists in LasVegas, April 29. May 2 he was an invitedlecturer at the University of SouthernCalifornia where he gave a researchseminar and a clinical grand rounds lecture.He was recently elected to serve as amember of the Board of Directors of theBarren Foundation, a philanthropic organization concerned with research in infertility and reproductive endocrinology.The Barren Foundation sponsors seminars in this area. The last one was heldMay 8, in Chicago on "Cervical andImmunological Factors in Human Reproduction." Dr. Schumacher presenteda lecture entitled: "Hormonal Effects onthe Secretions of the Human Cervix" onthis occasion."Dr. Schumacher has been namedprincipal investigator for two studies incontraction. The first, a two-yearcooperative contract from the WorldHealth Organization is to study "LowMolecular Weight Proteinase Inhibitorsin Human Cervical Mucus During Presumably Ovulatory Cycles," and will bedone in collaboration with a medicalschool in Germany. Funding is for$28,000 per year. The second, a twoyear project, recently approved byWorld Health Organization for $30,000per year, is to study "Immune Responseafter Local Application of Antigens inthe Rhesus Monkey." Dr. Sen-LianYang Assistant Professor in the Department of Obstetrics and Gynecology,will be the co-investigator on this project.Dr. Douglas R. Shanklin, Professor inthe Departments of Obstetrics andGynecology and Pathology, discussed"Binding of Oxygen to its Receptor as First Phase of Oxygen Injury to Lung"at the 71st annual meeting of the American Association of Pathologists in conjunction with the Pediatric PathologyClub meeting in March. Following themeeting he was Visiting Professor atChildren's Hospital, Vancouver, B.C.,Canada, and presented a seminar on"Hyaline Membrane Disease-AnimalModels of Pathogenesis."Dr. George L. Wied, Blum-Riese Professor of Obstetrics and Gynecology andProfessor of Pathology, and Head of theSection of Cytology, was electedPresident-elect of the InternationalAcademy of Cytology. He took office inMiami Beach June 1 at the Fifth International Congress of Cytology.Dr. Frederick P.· Zuspan, JosephBolivar DeLee Professor and Chairmanof the Department, has accepted thechairmanship of the Department of Obstetrics and Gynecology at Ohio StateUniversity College of Medicine, wherehe earned his M. D. degree.As past president of the Association ofProfessors of Gynecology and Obstetricians, he moderated a panel discussionon "Projections for the Future-Academic Faculty Needs and Funding" at the Association's meeting inNew Orleans, March 3-5. He also was apanel member on a "Mini Course for'new' chairmen."The Mothers' Aid of the ChicagoLying-in Hospital presented a check for$100,000 to Dr. Zuspan at its 70th anniversary luncheon May 8. The donationbrings to $560,000 the amount raised bythe organization on its $750,000 pledge.OphthalmologyThe following participated in the AnnualResidents Meeting of the ChicagoOphthalmological Society, April 3: Dr.Karl J. Fritz (71) "Optical Properties ofOpacities in the Cornea," Dr. Walter H.Stern (70) "Classification of the JuvenileMacular Dystrophies," Dr. Kenneth R.Diddie (73) "The Effect of Argon LaserPhotocoagulation on the Retinal andChroidal Vasculature" and Dr. RonaldSchachar "The Relationship of LensTransparency to Its Ordered Structure."Dr. Frank Newell, the James andAnna Louise Raymond Professor andChairman of the Department, deliveredthe William Lang Lecture at the RoyalSociety of Medicine and received theGold Medal. The title of Dr. Newell'saddress was, "The Challenge of RetinalPigment Epithelium."PathologyAppointment:Frank Kocka, Ph. D.-Assistant Professor.39James BowmanDr. James E. Bowman, Professor inPathology, Medicine, the Committee onGenetics, and in the College, waselected president of the MetropolitanChicago Blood Council. Dr. Bowmanalso is Medical Director of theUniversity's Blood Bank, Director ofLaboratories and Director of the Comprehensive Sickle Cell Center.Dr. Frank W. Fitch ('53) Professor ofPathology, has been appointed Chairman of the Committee on Immunologyfor a three-year term.Dr. Henry Rappaport, Professor ofPathology and Head of Surgical Pathology, was the first speaker at a seminar onthe reticuloendothelial system (RES),March 13-14 during the 63rd annualmeeting of the International Academy ofPathology, U. S. -Canadian Division,held in San Francisco. Dr. Rappaport isa world-wide authority on the RES. Heserves as chairman of the PathologyPanel, established by the NationalCancer Institute in 1967 to evaluatemulti-institutional clinical trials of lymphoma chemotherapy for cancers.Dr. Francis H. Straus II (57) Associate Professor of Pathology, with Dr.Ann M. Lawrence and Dr. EdwardPaloyan (56), (former faculty, now professors at Loyola's Stritch School ofMedicine,) has co-authored Hyperthyroidism (one in the series, "ModernSurgical Monographs"), New York,Grune and Stratton, 1974.40 In the last issue of Medicine On theMidway, it was reported that the Department of Pathology had two graduatestudents. This number should have been29. We're sorry.The following papers were presentedby the department recently: Dr. John R.Esterly, Associate Professor in the Departments of Pathology and Obstetricsand Gynecology, and Janet H. Pine,"Hydrocarbon Pneumonitis" given atthe Pediatric Pathology Club-- American Association of Pathologists meetingin San Francisco, March 9. At the samemeeting, Dr. Esterly, D. A. Baron,Janet Pine, and Dr. Ward R. Richter,Professor of Pathology and Director ofthe A. J. Carlson Animal ResearchFacility, spoke on "Ultrastructural andHistochemical Observations on PapainInjury to the Lung." At the AmericanAssociation of Pathologists and Bacteriologists Meeting in San FranciscoMarch 10, T. Ledet, Katti FisherDzoga, Research Associate in Pathology, and Dr. Robert W. Wissler, DonaldN. Pritzker Professor in Pathology, (48),presented a paper on "Diabetic Mac-Henry Rappaport roangiopathy: In Vitro Study of the Proliferation of the Aortic Smooth MuskeCells." At the same session DragoslavaVesselinovitch, Research Associate inPathology, Katti Fisher-Dzoga and Dr.Robert Wissler, presented "The Effectof Estrogen on the Rabbit Aortic MedialTissue Culture Cells." Dr. AndrewChurg (73), intern, under the sponsorship of Dr. Werner Kirsten, Professor ofPathology and Chairman of the Department, presented a paper on" Histochemical Demonstration of Cytochrome Oxidase in a Species of Chemically InducedAbnormal Mitochondria" at the samemeeting.Dr. Robert Wissler and Mrs. RoseJones have been awarded a 2-yearChicago Heart Association grant tostudy the Ultrastructure of Atherosclerotic Lesion in Young People. Dr.Wissler recently participated in the ShortCourse in Comparative Pathology, heldat the AFIP May 13-15. He presented alecture on the Comparative Pathology ofAtherosclerosis. He also presented aseminar on Problems and Progress in theUnderstanding of Atherosclerosis at theLobund Laboratory at the University ofNotre Dame June 19.At the Workshop on Arterial WallMetabolism held May 16-18 at AlbanyMedical College, N. Y. Ms. Rose Jones,research associate, spoke on "A Studyof Primary Cultures of Monkey AorticMedial Cells in Normal and Hyperlipidemic Serum; Electron MicroscopicObservations," and Dr. Robert Chen,resident-trainee, spoke on the "Effect ofHyperlipidemic Lipoproteins on theLipid Metabolism of Rabbit Aortic Medial Cells in Vitro."PediatricsPromotion:Richard M. Rothberg (58)-to Professorof Pediatrics and Pathology.A Master's Degree Program in Orthodontics to be offered in the Department of Pediatrics was approved by thefaculty of the Division of the BiologicalSciences. The program will trainteachers, researchers, and clinicianswho already hold D.D.S. or D.M.D.degrees.The following participated in theNinth Annual Conference of the Association for the Care of Children in Hospitals, held May 29-June 1, in Chicago:Dr. Marc O. Beem (48), Professor ofPediatrics; Dr. James V. Lustig (72) Resident in Pediatrics; and Dr. Joseph F.Terrizzi, Assistant Professor of Pediatrics.Glyn Dawson, Ph.D., Assistant Professor in Pediatrics and Research Associate in the Department of Biochemis-try and Joseph P. Kennedy Jr. Scholar inPediatrics, was appointed to the MedicalAdvistory Board of the National TaySachs and Allied Disorders Association,Inc. Dr. Dawson spoke at the AmericanSociety for Neurochemistry Meeting inNew Orleans, March 11-14. He wasco-chairman of a session on "ChemicalPathology" and co-author (with Dr.Grace Tsay and Dr. Reuben Matalon,Assistant Professor in Pediatrics) of apaper on "Human mannosidosis:neurovisceral storage disease resultingfrom a mannosidase deficiency."Dr. Albert Dorfman, (44), Richard T.Crane Distinguished Service Professorin the Department of Pediatrics, Director of the Joseph P. Kennedy,Jr. MentalRetardation Research Center and Professor of Biochemistry, participated inseminars in biochemistry at Iowa StateUniversity, March 21. He spoke on"Enzymic Defects in Mucopolysaccharidosis." April 8-12 he spoke on"The Role of Connective Tissue Cellsand Synthesis of Matrix and Collagen"at an International Symposium onWound Healing in Rotterdam, Hollandand on April 29 he gave seminars inBasic Science Research at the University of Alabama.Dr. J. Laurence Hill, Assistant Professor in Pediatric Surgery, was awardeda Schweppe Foundation Fellowship forthree years.Dr. Richard Rothberg (58) Professorof Pediatrics and Pathology, wasawarded a $1,000 advance grant to studythe identification and description ofbiochemical abnormalities of Cystic Fibrosis from the National Cystic FibrosisResearch Foundation. Many in the department are studying this disease andclinical training programs make it possible for junior and senior medical students to spend time with at least one patient with Cystic Fibrosis before they gettheir M.D. degrees. The pediatric residency schedule includes six weeks ofexperience in the CF clinic. This givesstudents and residents an overview ofbasic research in CF and the clinical andpsychosocial aspects of the disease. Thefocus is on treatment of the specific medical and psychological problems of thepatient and his family.PsychiatryDr. Daniel X. Freedman, Louis BlockProfessor and Chairman of Psychiatry,was awarded an honorary Doctor of Science degree by Wabash College, May19. He was cited for his studies on brainfunction linking psychiatry and neurology. He has also been elected presidentof the Association for Research inNervous and Mental Disease, which will hold its annual meeting in New York inDecember.Dr. Lawrence Z. Freedman, Foundations Fund Research Professor inPsychiatry, delivered two papers at themeeting of the American Orthopsychiatric Association in San Francisco, April8-12. They were: "Truth Drugs and Social Control of Violence," and "Terrorism: Policy, Pathology or Politics:"(co-author Dr. Harold Lasswell). Dr.Freedman was co-moderator for a session on brain research and a panelist foranother session concerning television'simpact on children. At the WorldAcademy of Arts and Sciences meeting,May 6-11, he presented a position paperon agression and violence with recommendations for crucial areas of research.He also was a participant on a recenttelevision program of "The Advocate"on the issue: "Resolved that the insanitydefense for criminal behavior beabolished. "Israel Goldiamond, Ph. D., Professorin the Departments of Psychiatry andPsychology and the College, contributedthe following article to Behaviorism,Vol. 2, No.1, June, 1974: "Toward aConstructional Approach to Social Problems: Ethical and Constitutional IssuesRaised by Applied Behavior Analysis."Dr. Chase P. Kimball, Associate Professor in Psychiatry and Medicine, haswritten the following articles: "The Second Annual Psychiatric Liaison Workshop," Psychosomatic Medicine,January-February, 1974; "Delirium,"Current Therapy, 1974, H. F. Conn,ed., W. B. Saunders Co., pp. 833-35;and "Psychological Aspects of Cerebrovascular Disease," Medical Insight,February, 1974. In April he spoke on"Dehumanizing Effects: ExperimentalStudies" at the 70th annual congress onMedical Education of the AmericanMedical Association, Chicago. Recentappointments include: Member of theBoard of the rtIinois Council on Continuing Medical Education, the Council ofthe New England Board of Higher Education, Board of Editors of PsychoEcology, the new journal of the International college of PsychosomaticMedicine and member of the searchcommittee for a president and dean ofthe American Indian Medical School.He also is chairman of the Health Professions' Education Committee of theNavajo Health Authority.Radiology:Appointments:Mortimer M. Elkind, Ph.D.-Professorin the Department of Radiology and Argonne National Laboratory. Professor Elkind, a biophysicist, has been associated with the National Cancer Institute since 1949. He has a Ph.D. fromMassachusetts Institute of Technology.Dr. John J. Fennessy, Professor in theDepartment of Radiology, has been appointed Chairman of the Department ofRadiology for a three-year term. Dr.Fennessy was a resident from 1960-1963and has been a member of the facultysince that time. In 1969 he received theJames A. McClintock Award as the outstanding teacher in the Medical School.John FennessyDr. Alexander Gottschalk, Directorof the Franklin McLean Memorial Research Institute and Professor ofRadiology, was,installed as a Fellow ofthe American College of Radiology atthe College's 51 st annual meeting inNew Orleans, April 2. In June he wasinstalled as president of the Society ofNuclear Medicine at the Society's annual meeting in San Diego. Dr.41Gottschalk delivered the following lectures: "Liver Scanning-NormalAnatomy and Artifacts," and "LiverScanning-Pathology," at the TexasRadiological Society, San Antonio, inMarch and The Ross Golden lectureApril 26 at the spring meeting of the NewYork Roentgen Society on "N uclearMedicine-Where We Are, Where WeOught To Be, Where We May BeGoing"; and a report on "PulmonaryEmbolism" was delivered at the meetingof the Fleischner Society, held at theRoyal College of Surgeons, May 20-23,in London, England.Dr. Lee B. Lusted, Professor and Faculty Secretary, has been elected President of the Chicago Radiological Societyfor 1974-75.SurgeryAppointment s:Dr. John D. Burrington-Professor ofSurgery and head of the section ofPediatric Surgery. Dr. Burrington is aspecialist in gastro-intestinal problems inchildren, fetal surgery and problems ofthe newborn. He formerly was chief ofthe section of pediatric surgery andsurgeon-in-chief of Denver Children'sHospital. He graduated from HarvardMedical School in 1960.Dr. George E. Block, Professor inSurgery, discussed the film, "Anatomical Considerations in Thyroidectomy,"at the 2nd annual spring meeting of theAmerican College of Surgeons, Houston, Texas, March 25-28.Dr. Kishan Chand, Associate Professor in Surgery (Orthopedics) is author of"The Knee Joint in RheumatoidArthritis-The Role of Synovectomy,"in International Surgery, February,1974. Four more articles on this subjectwill be published in later issues.Dr. Jack de la Torre, Assistant Professor in Surgery (Neurosurgery) is theauthor of "Dimethyl Sulfoxide in theTreatment of Experimental Brain Compression," in the Journal ofNeurosurgery, 38 (1973).Dr. Edwin L. Kaplan, Associate Professor in Surgery, was a co-author of thefollowing paper presented at the American Surgical Association meeting inColorado Springs May 2: "Ulcer Disease, Metabolic Alkalosis and Hyperparathyroidism: A Mechanism of Interrelationship?"Dr. Ramon Lim, Assistant Professorof Surgery (Neurosurgery) andBiochemistry, was awarded a two-yeargrant for $76, 934 from the National Institutes of Health for" Studies on BrainProteins.' ,The following members of the Sectionof Otolaryngology participated in the42 Chicago and Illinois State MedicalSocieties' 31st Annual Midwest ClinicalConference, April 3: Dr. Ralph Naunton, Professor of Surgery and Head ofthe Section of Otolaryngology, and Stanley Zerlin, Ph.D., Research Associate,presented "Electrophysiological Assessment of Hearing"; Dr. GregoryMatz, Associate Professor and Harris J.Mowry, M.A., Clinical Audiologist,presented "Otologic Surveillance of Retarded Children,"; Drs. Naunton andZerlin gave presentations at the International Congress of Audiology in Paris,France, April 24-26. They spoke on"Physical and AudiologicalSpecifications of Third-Octave Clicks"and "Whole-Nerve Response to Clicksof Different Frequency." Following thismeeting they visited laboratories engaged in simi liar reseach in electrocochleography in Bordeaux, Erlanger,Leiden, and Copenhagen.Robert Butler, Ph.D., Professor ofSurgery (Otolaryngology) was awarded atwo-year grant of $76,734 from the National Institute of Neurological Diseasesfor "The Role of Spectral Cues in SoundLocalization.' ,Dr. John Gorney, Resident inOtolaryngology, won the Lederer- PierceAward for excellence in basic researchawarded by the Chicago Laryngologicaland Otologic Society. The award wasgiven for the best research paper presented at the residents' competition. Thetitle of his paper was "The Effect of aDifference Tone on the AuditoryEvoked Response of Humans."Dr. Leonard R. Proctor, AssociateProfessor of Surgery (Otolaryngology)was awarded a $23,318 research grantfrom the National Institute of Neurological Diseases for the" Study of Vestibular Pathways in the Cerebellum."Zoller Dental ClinicGeorge W. Barnhart, Master Dental andMaxillo facial Prosthetic Technician andSupervisor of the Prosthetic Laboratory,has been awarded the Exalted Order ofthe Bumblebee by the AmericanAcademy of Plastic Research in Dentistry. The award was presented February10 at the Academy's Award meeting.Mr. Barnhart has developed prosthesesthat mimic natural complexion and facialcharacteristics for patients disfigured byradical surgery for oral cancer. He wonthe award for his pioneer research in the1960's on silicone rubber, acrylic andother materials used in mouth and facialprostheses for patients with oral, facialand neck surgery. He also had adaptednew plactic materials for prostheses toreplace portions of the hard palate lostthrough cancer surgery and has designed intracavitary radium carriers by whichmouth cancer patients may recei veradium treatments. He has developedresilient hollow bulb obdurators that fillsurgically created holes in the patient'soral cavity, thereby allowing the patientto eat and speak normally and to swallowliquids. Mr. Barnhart has been with Zoller Clinic twenty-five years.Dr. Frank J. Orland, Professor ofDental Surgery, has written a book onThe First Fifty-Year History of (he International Association for DentalResearch. In addition to providing extensive data about the Association, thebook traces the development of the workof the Association and of dental researchin the context of the growth of science ingeneral.Alumni News1923Harold I. Meyer, Chicago, has retiredafter 45 years of service with the rank ofsenior attending surgeon emeritus,Presbyterian-St. Lukes Hospital andprofessor of surgery emeritus, RushMedical College.1925Libby Pulsifer, Penfield, New York, received an honorary doctor of science degree from Colby College, Waterville,Maine, where he earned his undergraduate degree in 1921. Dr. Pulsifer is aclinical assistant professor of medicineemeritus at the University of RochesterSchool of Medicine and Dentistry andformer chief of medicine at RochesterGeneral Hospital. He joined the University of Rochester medical faculty in 1927and became emeritus in 1964. While onthe staff of Rochester University'sStrong Memorial Hospital he helped organize the gastroenterology clinic. In1971 he received the Albert DavidKaiser Medal, the highest award for theRochester Academy of Medicine.1927Theodore J. Smith, Sarasota, Florida,recently was elected president of theSarasota and Bradenton, Florida RetiredPhysicians and Dentists Club.1929S. W. Simon has partially retired to 177Ocean Lane Drive, Key Biscayne,Florida. During working hours he practices an an allergist.1931Egbert H. Fell, Kailua-Kona, Hawaii, isnow emeritus professor of surgery,Rush-Presbyterian-St. Luke's MedicalCenter, Chicago. He still serves as consulting surgeon at Presbyterian-St.Luke's Hospital and consulting surgeonat Kona Hospital in Hawaii.Albert A. Terry, Austin Texas, is retiring from practice.1932Nathaniel E. Reich, a cardiologist withoffices in Brooklyn, New York, is listedin the second Edition of Who's Who inthe World.1934Alfred J. Benesh, Seattle, sent the following note, "I am now a semi-retiredradiologist, enjoying work and someplay. "1937AlfT. Haerem after 28 years in the practice of internal medicine writes, "I amgoing to take a long rest and get intosomething else." Dr. Haerem lives inRedwood City, California.1938Merton M. Gill, Chicago, is a professorof psychiatry at the Abraham LincolnSchool of Medicine.1939E. W. Haertig, clinical associate professor of psychiatry at the University ofHawaii School of Medicine, has recentlyco-authored, Nana I Ke Kumu (Look tothe Source), an anthropologicalpsychiatry study.William Wallace Scott received anhonorary doctor of science degree May11 at the 102nd annual commencement ofthe University of Missouri in Columbia,where he earned an A. B. in 1934. Dr.Scott, professor of urology and chairmanof that department at Johns HopkinsUniversity School of Medicine, washonored by his former residents with thepresentation of his portrait to the medical school. The painting, by RichardLahey, was given in admiration andgratitude for Dr. Scott's great leadershipand inspiration.1941Clara Johns, Kaiser Hospital, SantaClara, California, will serve a secondterm as president of the hospital staffnext year.1942George H. H andy is president of theState of Wisconsin and ProvincialHealth Officers Association for 1973-74.Dr. Handy lives in Madison. 1944Morton Lee Pearce, writes from LosAngeles, where he is chief of the divisionof cardiology and professor of medicineat U.C.L.A., "Our problems at TheUniversity of California are the same asany other medical school: growing enrollment and patient load coupled withreduced financing. Like most of myclassmates, our children are adults andvariously involved in early education,cabinet making (one piece at a time, original designs only), and mathematicalphysics. "Raymond D. Goodman was electedpresident of the U.C.L.A. School ofPublic Health Alumni Association for atwo-year term.Robert W. Jamplis is president-electof the American Association of MedicalClinics. He also serves as executive director and head of the department ofthoracic surgery at the Palo Alto Clinicand clinical professor of surgery at Stanford University School of Medicine.1946Jack Berger became a lecturer inpsychiatry at The University of Chicagolast September, serving as liaison between the psychiatry and surgery departments. He is in private practice, andis clinical assistant professor ofpsychiatry at Rush Medical College, ison the attending staff of St. Luke's Hospital, and is consultant in psychiatry tothe plastic surgery department at CookCounty Hospital.Edward O. Lukasek, Sparta, Wisconsin, is senior staff physician at theTomah V.A. Hosptial.1947Edyth H. Schoenrich, Director of theAdministration for Services to theChronically III and Aging in Baltimore,Maryland, has recently been appointedchairman of the Board of Trustees of theCommission on Accreditation of Rehabilitation Facilities (CARF). For several years she has served as the American Hospital Association representativeto the Board of Trustees of this organization. CARF sets standards for and carries out an accreditation process in program areas of physical restoration, socialadjustment, vocational adjustment, sheltered employment, speech pathology,audiology and, most recently, programevaluation.1950Bernard Barash has moved from NewJersey to 202 Nassau South, VeniceFlorida, where he has a private practicein psychiatry. He is also clinical directorof Sarasota Palms Hospital. Richard M. Bernard, Portland,Oregon, was named president-elect ofthe Oregon Academy of Family Physicians at its 27th annual scientific assembly in May. Dr. Bernard is a chartermember of the Board of Family Practice.Last October, he was inducted as a Fellow of the American Academy of FamilyPhysicians.Harry G. Kroll is in private practice oforthopedic surgery in Topeka, Kansaswhere he serves as clinical instructor oforthopedic surgery at the University ofKansas Medical Center. In 1971 and1973 he served as a volunteer orthopedicconsultant in the Dominican Republicwith CARE-Medico.1953Clayton B. Edisen has a new position asprofessor of experimental communications, Department of Teacher Education, Tulane University, New Orleans.He is a member of the Ph. D. Dissertation Examination Committee in that department and is president of EdisonCommunications, Inc.1954Richard Chessick has been promoted toprofessor of clinical psychiatry atNorthwestern University MedicalSchool. Dr. Chessick also is senior attending psychiatrist at Evanston Hospital. His third book, The Technique andPractice of Intensive Psychotherapy,was published by Aronson Books, N. Y.in (1974).1957Joseph Richard, Yorktown Heights,N. Y., was inducted as a Fellow of theAmerican College of Physicians at theCollege's annual meeting in N ew YorkApril I. Dr. Richard was a guest at theMedical Alumni reception that evening.1959Lawrence D. Freedman was electedChief-of-staff of La Mirada CommunityHospital, La Mirada, California.Wendell Weber43Wendell W. Weber has moved to 14Geddes Heights, Ann Arbor. He hasbeen appointed professor of pharmacology at the University of Michigan. Hewas formerly professor of pharmacologyat New York University.1960Guy D. Potter, professor of radiology atthe Columbia-Presbyterian MedicalCenter, was invited to address the Association of Radiologists of West Africaat its annual meeting in February inMonrovia, Liberia. The Association iscomposed of radiologists from Nigeria,Liberia, Ghana, Sierre Leone, Togo,Senegal, Dahomey, and Mali. Dr. Potteralso delivered a series of lectures onradiology of the ear, the sinuses and themandible from the standpoint of trauma,tumor, and infectious disease which areof particular interest to these West African nations. Before returning to theStates, he consulted with the staff members of the University of Ibadan inNigeria and the John F. Kennedy Medical Center in Liberia on radiologicalproblems and questions of health caredelivery.William Riley is clinical associate professor of neurology at the University ofTexas Medical School at Houston and amember of the following organizations:Society for Neuroscience, British BrainResearch Association, European Brainand Behavior Society, 1973, and International Child Neurology Association.Duane W. Taebel is president of themedical staff of LaCrosse LutheranHosptial, in LaCrosse, Wisconsin. He isalso director of the AlcoholDetoxification Unit at the AlcoholismCenter.1963Ira Finegold is clinical assistant professor of medicine at the University ofMiami and a Diplomate of the AmericanBoard of Allergy and Immunology.Mark Silverman became associateprofessor of medicine (cardiology) atEmory University School of Medicine inAtlanta last August.1964Robert J. Costarella, Arcadia, California, is board certified in plastic surgeryand has a large hand surgery practice.He did a hand fellowship with Dr.Harold Kleinert at the University ofLouisville.David Dressler is chief of psychiatryat New Britain General Hospital, NewBritain, Connecticut, assistant professorof psychiatry at the University of Connecticut Health Center and assistantclinical professor of psychiatry at YaleUniversity.44 Lawrence Kass (M.S. Anatomy 64) isassociate professor of internal medicineat the University of Michigan and amember of the permanent staff of theSimpson Memorial Institute. Dr. Kass isthe author of three new books: BoneMarrow Interpretation, MonocytesMonocytosis and Monocytic Leukemia,and Refractory Anemia, all published byCharles C. Thomas, Springfield, Illinois.Dr. Kass is completing a volume on pernicious anemia for 1975 publication.George S. Rhyneer is in his third yearof private practice as a cardiologist inAnchorage and serving his second yearas Chief of Medicine at ProvidenceHospital where he is co-director of thecardiac catherization lab, the only suchfacility in Alaska. He was instrumentalin planning the first coronary arterysurgery performed in Alaska. After aninternship and residency at The University of Chicago, Dr. Rhyneer took a cardiology fellowship at the University ofOregon. His first trip to Alaska was asacting director of the State of Alaska TBControl Unit, after which, he decided toremain permanently, Dr. Rhyneerserves as president of the Alaska HeartInstitute and chairman of the AlaskaHealth Sciences Information Center.1965Wayne E. Janda passed the OrthopaedicSurgery Board examination last September and is now practicing in San LuisObispo, California.1966Jay S. DeVore just completed six yearsin the Navy and has joined the faculty ofthe University of Pennsylvania Schoolof Medicine as assistant professor ofanesthesiology and assistant professor ofpediatrics. Dr. DeVore is co-director ofobstetrical anesthesia at the Hospital ofthe University of Pennsylvania.John E. Kurnick now lives at 77Ivanhoe Street, Denver, Colorado80220. He has a new position as chief ofhematology at Denver V.A. Hospitaland is assistant professor of medicine atthe University of Colorado MedicalCenter.Julian J. Rimpila became senior fellowin gastroenterology at The University ofChicago, July 1. The Rimpilas have justmoved to a new home at 11049 WindsorDrive, Westchester, Illinois.Daniel Rosenblum is assistant professor of medicine at Washington University and director of hematology at TheJewish Hospital of St. Louis.Michael L. Shelanski has returned tothe U.S.A. from Paris, France and is associate professor of neu rology andneuropathology at Harvard MedicalSchool. 1967Sidriey P. Kadish completed militaryservice and is assistant radiationtherapist and assistant professor of radiation medicine at Rhode Island Hospital, Providence.Deborah Scherz Rose has a new address, 1542 Hamilton Avenue, PaloAlto, California 94301 and a new position as an Associate of the CollectivePsychotherapy Center in Palo Alto. Dr.Rose writes, "The Center is a uniqueexperiment in providingpsychotherapeutic care to the community. It is run as a collective and is a selfsupporting sliding-scale private clinic. InMay we had a mini reunion with Sauland Judy Wasserman, Les and MarshaJacobson, Dave and Gale Perrin andChip Panzarella."Stanford Shulman, Gainesville,Florida, is assistant professor of pediatrics. He is doing research in immunology of rheumatic fever and rheumaticheart disease.1968David Kaufman and Stephen Scher bothattended the alumni reception during theAmerican College of Physicians meetingin New York. David takes over as chiefresident in neurology and Stephen aschief resident in pulmonary medicine,both at Albert Einstein College ofMedicine.Joan A. Lang is now Joan Lang Howard. She is completing a residency inpsychiatry at U.C.L.A. Neuropsychiatric Institute and will begin private practice in Los Angeles. She was appointed aGinsberg Fellow to the Group for theAdvancement of Psychiatry.Timothy C. Lindquist finished his residency and is off for the wilds ofMichigan, where he will take up an orthopedics practice in Battle Creek. Hepresented a paper on "Alternate Approach to Lumbo-Sacral Agenesis" atthe annual meeting of the American Orthopedic Association in San Francisco inJune.Jack C. Sipe completed a special fellowship in neuropathology at StanfordUniversity and has been appointed assistant professor of neurosciences at theUniversity of California Medical Schoolat LaJolla. Dr. Sipe took his internshipand residency in neurology at The University of Chicago.Richard Sohn completed service withthe U.S. Navy in July and has joinedWashington University as an instructorin neurology. His new address is 9810Warington Square, St. Louis 63141.1969John Chiles has left The University ofChicago after completing his residencyin radiology and a year as instructor andhas joined the department of radiology atOhio State University in Columbus.Karen Leininger Kaplan is completinga fellowship in hematology at CornellMedical School and is going to ColumbiaUniversity College of Physicians andSurgeons as research associate in thedepartment of medicine. Her husband,Jonathan is a neurologist in private practice. They are the parents of Joshua,born last August.William Weese completed a fellowshipin pulmonary diseases at MassachusettsGeneral Hospital in June and wasawarded an Edward Livingston Trudeaufellowship by the American Lung Association to continue research work(bradykinin sites of activation and inactivation in the lung) at the faculty level.Dr. Weese will be an instructor inmedicine at Harvard Medical School andon the Staff of Massachusetts GeneralHospital.Laurens D. Young, wife Joanne andtwo daughters, Jennifer 4 and Elizabeth2, are moving from Madison, (where hehas been instructor of psychiatry at theUniversity of Wisconsin) to Charleston,South Carolina. He will be assistant professor in the department of psychiatry atthe Medical University of SouthCarolina.1970Nathan Goldstein III was appointed assistant professor in the department ofpediatrics at Riley Hospital IndianaUniversity, where he is coordinator ofpediatric ambulatory services and coordinator of Indiana Services for CrippledChildren. The Goldsteins have a daughter Lisa Michelle, born January 30.Robert Karp and his wife announcethe birth of their second child, DavidArnold. Dr. Karp is a Captain with the9th Medical Detachment, APO NewYork.Lauren and Michael Plumer write:"Mike is assistant professor of anesthesiology at The University of California, San Diego, and co-director of obstetric anesthesia at University Hospital. Lauren says it's none of anybody'sbusiness what she's doing-anyone whowants to know can send a stamped,self-addressed envelope-but for the record, she's a pediatrician at a pediatricfree-clinic in San Diego and it's OK tosay that. Son Douglas Michael will beone year old in July."Michael Sherlock completed his residency at Childrens' Hospital inPittsburgh and has been appointed a fellow in child psychiatry at Johns HopkinsHospital. 1971Richard Heinrich is chief resident in thepsychosomatic-liaison service at theNeuropsychiatric Institute at U.C.L.A.,where he is a third year resident.Theodore Ingis finished a two-year assignment with the U.S. Public HealthService Clinic in San Diego and hasstarted an ophthalmology residency atthe Manhatan Eye, Ear, and ThroatHospital. -Gerald Lee Schertz in July took overas chief medical resident at Yale NewHaven Hospital.Gordon Telford is beginning his thirdyear residency in general surgery at theUniversity of Iowa Hospital. He recently won the Department of SurgeryPrize for the best scientific paper. Histitle was "Enhancement of Small BowelTransplants in Rats."1972David L. Dodge is a major with the 6thArmy Medical Lab, Fort Baker,California.1973James Schwanke, San Francisco, hasbegun a pediatrics residency at the U niversity of California at San Francisco.Former StaffBostros A. Bassali (Anesthesiology Resident '70-'73) is associated with Suburban Anesthesiologists in La Grange, Illinois.Marshall B. Block (Medicine Intern,Resident and Endocrinology Fellow'68- '72) has completed his military service and on August 15 joins Endocrinology Assoc. B.A. in Phoenix, Arizona.Rinaldo Canalis (Otolaryngology Intern and Resident '6�'72) is assistantchief, Head and Neck Division, HarborGeneral Hospital, and associate professor, U.C.L.A. School of Medicine.Robert Cutler (Medicine-NeurologyResident '61-'63, Associate Professorand Professor '68- '74) has joined the department of neurology at Stanford U niversity School of Medicine.Laurent G. Desbaillets (GeneralSurgery Resident '6� '68 and AssistantProfessor '68-'71) moved from Rochester, New York to 6, Avenue des Tilleuls,1203 Geneva, Switzerland.Jules L. Dienstag (Medicine Internand Resident '72-'74) is a research associate at the National I nstitutes ofHealth in Bethesda.Paul R. Dinsmore (Intern 58) hasstarted a multi-disciplinary private practice group of two psychiatrists, onePh. D. psychologist, and three senior psychiatric social workers at the Mt.Auburn Hospital in Cambridge, Massachusetts. He is the author of" Lithiumin Schizo-Affective Disorders" in Diseases of The Nervous System.Edward Ehrlich (Medicine Resident57; Instructor-Professor '60-'74) hasbeen appointed associate chairman, department of medicine, University ofWisconsin Medical School.Thomas L. Fisher (Dermatology Resident '70-'73) has a private practice atWilliams Clinic Ltd., Chicago.Jerome A. Gans (Resident and Instructor ' 39-' 43) has moved to 22500 S.Woodland Road, Shaker Heights, Ohioand has an office at Parkway MedicalCenter in Beachwood.Lawrence Gilbert (Intern '73) is takinga pathology residency at the Universityof Wisconsin.Michael Goldberger (Anatomy Faculty: Assistant-Professor '68-'73) isjoining the department of anatomy at theMedical College of Pennsylvania,Philadelphia.Ronald Hendrix (Radiology Residentand Instructor '70-'74) has reported tothe Department of Radiology at GreatLakes Naval Training Center, GreatLakes, Illinois.Emma Hughes (Ob-Gyn Intern 33)has retired and lives in Lorna Linda,California.Jerome Jaffe (Psychiatry Assistantand Associate Professor '68- '73) is withthe department of psychiatry at Columbia University College of Physicians andSurgeons.In Kim (Anesthesiology Resident-Assistant Professor '69-'74) is atAlexian Brothers Medical Center, ElkGrove Village, Illinois in the departmentof anesthesiology.Mansour Kiumehr (Intern '73) is training in obstetrics and gynecology at Pontiac General Hospital in Pontiac,Michigan.Stanford Lamberg (Dermatology Assistant Professor '70-'73) has gone toJohns Hopkins University Hospital asassociate professor.Ann Lawrence (Medicine Intern andResident '60-'62; Instructor-Professor'64- '74) has joined the Stritch School ofMedicine as Professor of Medicinewhere she will establish a medicalsurgical endocrinology program. Shealso will work with Edward Paloyan (56)at the V.A. Hospital at Hines.Bernard Larner, Ph.D. '73 (Intern andResident '68-'73) completed his residency in pathology and has joined thedepartment of clinical pathology at theUniversity of California Medical Centerin San Francisco.Malcolm Lesavoy (General Surgery45Intern and Resident '69-'74) received afellowship in plastic and reconstructivesurgery at the University of Miami.Philip M. Margolis (Psychiatry'56-'66), professor of psychiatry andprofessor of community mental health atUniversity Hospital, Ann Arbor, has authored a new book, Patient Power: TheDevelopment of a Therapeutic Community in a Psychiatric Unit of a General Hospital, published by Charles CThomas, Springfield, Illinois.James Marks (Radiology Resident,Instructor and Assistant Professor'67-'74) has joined the Edward Mallinckrodt Institute of Radiology in St.Louis.William McCartney (Radiology Resident and Instructor '70-'74) is stationedat William Beaumont Army MedicalCenter, Department of NuclearMedicine, EI Paso, Texas.Daniel McCarty (Medicine Professor'67-'74) former professor of medicineand head of the section of arthritis andmetabolic disease at The University ofChicago, has been named chairman ofthe division of medicine at the MedicalCollege of Wisconsin.Marion Murray (Anatomy AssistantProfessor '69-'73) has joined the department of anatomy at the Medical College of Pennsylvania, Philadelphia.Neel Nathanson (Intern and Resident'53-'55) is professor and head, divisionof infectious diseases, at Johns HopkinsUniversity School of Medicine.Fredric Pashkow (Medicine Resident'72-'74) is at Fort Campbell Hospital,Fort Campbell, Kentucky in the department of internal medicine.Frederick W. Platt (Medicine Internand Resident '64-'66) is director ofmedicine, Presbyterian Medical Center,Denver. His book, Case Studies inEmergency Medicine, was published byLittle, Brown and Co., Boston, inJanuary.Robert A. Ratshin (Medicine Internand Resident '67-'70) is one of five staffcardiologists at David Grant USAFMedical Center, Travis AFB, California. On separation from the USAF inSeptember, he will become assistant professor of medicine, director of the cardiac catheterization laboratory, and research associate in the CardiovascularResearch Institute at the University ofCalifornia-San Francisco MedicalCenter. Dr. Ratshin has authored orco-authored more than 40 articles oncardiology. The Ratshin family, including wife Leslie and son Jonathan, willlive in Moraga.David E. Raskin (PsychiatryAssistant-Professor '72-'74) is directorof in-patient service at the University of46 Washington, Harborview Campus, inSeattle.Pierre Renault (PsychiatryResident-Assistant Professor '66-'74)is at St. Elizabeth's Hospital in Washington, D.C.Mitchell Rhodes (Medicine Intern,Resident and Pulmonary Trainee'65-'70) is assistant professor ofmedicine at the University of Iowa. Hereceived a Pulmonary Academic Awardfrom the National Heart and Lung Institute for 1974-1979. He will become aFellow of the American College of ChestPhysicians at its November convocation ..Gwendolyn Lutz Scott (Medicine Resident '51-'53) writes, "I was an internist and cardiologist for thirteen years;then took a residency in psychiatry. I amnow in private group hospital practice atAnclote Manor Hospital in TarponSprings, Florida."Marvin D. Siperstein (Intern '48) formerly at the University of Texas Southwestern Medical School at Dallas, isprofessor of medicine; director, divisionof pathophysiology, department ofmedicine, University of California-SanFrancisco Medical Center; and chief,metabolism section, medical service,V.A. Hospital in San Francisco.H. Burr Steinbach (Zoology Professor'57-'72) is president of Oceanic Foundation, Makapuu Point, Waimanalo,Hawaii.Jack T. Stern, Jr. (Ph.D. '69;Anatomy Instructor and Assistant Professor '69-'74) is associate professor,department of anatomical sciences,Health Sciences Center, Stony Brook,New York.Robert J. Wilkus (I ntern '62) is assistant professor of laboratory medicine atthe University of Washington MedicalSchool in Seattle.Alice Yu (Intern '73) will begin a residency in pediatrics and immunology atChildren's Hospital in Boston, Massachusetts.Association ActivitiesOn May 1st, Dean Leon O. Jacobson(39), and Clifford W. Gurney (51), Deputy Dean, were the featured guests andspeakers at a dinner meeting of the LosAngeles area Medical Alumni. Following the showing of the University'Saward-winning film on cancer research,"The Quiet War," Dr. Gurney led adiscussion of the history and future ofcancer research. Dr. Jacobson thenbriefed the group on the new CancerCenter and other current and planned activities at the Medical School.Bernard G. Sarnat (36), President ofThe University of Chicago Club of Greater Los Angeles, served as host inthe absence of the Medical Alumnichairman, Richard D. Pettit (37), whowas out of the country. Three of the 46guests received special introductionsfrom Dr. Sarnat. These were FinisCooper and Clarence C. Reed, bothcelebrating their 50th class reunions thisyear, and Catherine Ann Lippman (73)the most recent Medical School graduatein attendance.The evening before, Drs. Jacobsonand Gurney had spoken to a meeting ofThe University of Chicago Club of theBay Area. Program chairman for the SanFrancisco group was J. Alfred Rider(44).Fall programs are planned in Boston,Detroit, and Portland. Dates will be announced later.Calendar of EventsWednesday, October 23Cocktail Party during AmericanCollege of Surgeons' meeting,Miami Beach, aboard the"Hondo," docked across from theFontainebleau Hotel, 5:30 to 7:30p.m. Spouses invited.You've Got a FriendDr. Tripple and his wife, (center) and family members, from left, Stephen (M.D.) and his wife Carol, David and Mark. Not shownare Mary, Grant and Barbara Tripple.�oduct of the South Side and "particularly of TheUniversity of Chicago," Dr. Otto Tripple has remainedclose to the source, where he has recently taken the gavelof the University of Chicago Medical Alumni Association.Dr. Tripple thinks of himself as more than just an individual who has graduated from a school. He views himself as a member of a very large and special medicalcommunity-consisting not only of those who graduatedwith him but of the students and faculty who followedand preceded him at the school.It will be this perspective that the newly elected Association president will try to pass on during his term. Hehopes to foster more activities with alumni, faculty andstudents so that they can be made aware of the extensivegroup to which they belong. His sense of the history ofthe University has a personal touch. He was trained during the Hutchins-Kimpton era under such titans as DallasPhemister, Lester Dragstedt, Eleanor Humpheys, William Adams, Charles Huggins, Dwight Clark, HilgerJenkins and Howard Hatcher.Otto Tripple first came to the University in 1940 to dohis undergraduate work in chemistry and anatomy. Likethe man who came to dinner, the doctor stayed, until hegot his M.D. degree in 1946. He went on to do both hisinternship (46-47) and residency (49-54) at The University of Chicago Hospitals and Clinics, serving for part ofhis residency as an instructor.In 1954, he left the campus to join staff of the Northwestern Medical complex, where he is now an AssociateProfessor in Surgery. Author of more than 60 papers onthe subject of vascular surgery, he is section chief of thatsub-specialty at the Veterans Research Hospital and isaffiliated with Lutheran General Hospital and St. Joseph's Hospital. He is also a member of the prominentnational vascular surgical societies.Over the years, the surgeon has remained active in theUniversity of Chicago Medical Alumni Association,serving as a member of the council (67-70), vicepresident (72), president-elect (73) and president (74).The school and the Association, he thinks, have become stronger with time. But there is still room forgrowth, he says. Among his objectives for the group are:-creating an improved fund raising arm to providebenefits for students and faculty-encouraging faculty attendance at Association meetings and alumni attendance at class reunions-and providing both social and educational experiencesfor alumni and faculty (such as the upcomingCruise/Seminar to Greece and Russia).Dr. Tripple, his wife and 6 children reside in Evanston.Mrs. Dorothy Bowman Tripple (A.M. 47) is a teacher atthe Evanston Township High School. Their children arebetween the ages of 18 and 26.Other members of the new slate of officers are:President-Elect-Henry Russe (57), Chairman, Department of Medicine, Columbus-Cuneo-Cabrini Medical CenterVice President-Asher Finkel (48), Director of theDivision of Scientific Activities, American Medical AssociationSecretary-Francis Straus II (57), Associate Professor, Department of Pathology, U of CMembers of Council 74-77-Sumner C. Kraft (55),Professor, Department of Medicine, U of C and DonaldRowley, (50) Professor, Department of Pathology, U niversity of Chicago.Medici�e on. the M"�l";3Y.. I', \The University of �!ll�P�,9 �; t.; .'j"", ',';The Medical Alunijfi �s��iation,: � ;:"".: -, ,,'The Pritzker Scho6l o:tM�icine ,:,' t: �- ,> '1025 East 57th Street .�{>!.' ,�>, ;., ',-, "', '""} .. ' ,.... .Chicago, Illinois 6063'1"- 'i:k<,�" � .�' ,!� �," :,•Address corrections requestedreturned postage guaranteedTh� Joseph Regenstein LibrarySerial Records Department, Roo�-2221100 East 57th StreetChicago, Illinois 60637 NON-PROFIT ORG.U.S. POSTAGEPAIDPERMIT NO. 9666CHICAGO, ILL.