Medicine on the MidwayDesign/Robert Lipma�In this issue . . .During the past year, millions have readabout heart transplants, and lively interestin this operation still prevails.This winter, a team of surgeons under Dr.C. Frederick Kittle, '45, Professor of Sur­gery and Head of the Section of Thoracicand Cardiovascular Surgery, conducted thefirst heart transplant at the University (seestory, P: 4). Yet, despite the public curi­osity that surrounds a transplant, manyphysicians at the University already regardthis «first" as ancient history. What shouldmake news, they feel, are the ongoing, be­hind-the-scene events that constitutegroundwork for tomorrow's transplants.Accordingly, this issue features some ofthe outstanding plans and contributions inthis field from University clinics and re­search laboratories. On our cover, Dr.Kittle and Dr. Magdi H. Yacoub (fore­ground), Instructor of Surgery, concentrateon a heart valve transplant, part of theirpreparation for more complex cardiovascu­lar techniques.Included in this issue are stories on im­munology research-how transplant rejec­tion and. acceptance may be predicted;on a new population control research pro­gram, and on an idea for a heart transplantregistry. Also in this issue, readers will learnabout some novel programs initiated by ourexpanding psychiatry department. It's allpart of the continuing search for more chal­lenging levels of excellence in medicine atThe University of Chicago.On the cover: Dr. C. Frederick Kittle, '45, confers with Dr.Magdi H. Yacoub (1.) during a heart-valve transplantation,performed on a calf. It is one of several research projects nowunderway to prepare for advanced cardiovascular surgicalprocedures at the University.Volume 24 Winter, 1969 No.2ContentsFord Foundation Announces Population Control Research Grant 2Lewontin Elected President of Evolution Society 2Dr. Resnekov Advocates Transplant Registry 3Dr. Hosobuchi Honored by Neurological Academy 3Surgical Team Performs University's First Heart Transplant 4Two Named Professorships Announced 5Perspectives Journal Wins Award 5Appointments 6Aspirin May Contribute to Ulcer Formation 8Kluver Receives Achievement Award 8Biological Science Division Affiliates with Michael Reese 8Researchers Seek To Control Immune Response 9Residents Trained in 'New Psychiatry' 14News Briefs 17In Memoriam: Jessie Burns Maclean 18News of Alumni 19Rush Alumni 20News of Former Faculty, Interns and Residents 20Faculty 21Association Activities 22Deaths 23Calendar of Events 24Faculty Comment: The Medical School and its Relationship to the Community 25Bulletin of the Medical Alumni Association of The University of ChicagoDivision of the Biological Sciences and The Pritzker School of Medicine950 East 59th StreetChicago, Illinois 60637Editor: Stuart Kaminsky Associate Editor: Mary H. SmithMedical Alumni Association: Douglas N. Buchanan, President; Jack C. Berger, '46,Vice-President; Sidney Schulman, '46, Secretary; Joseph H. Skom, '52, Treasurer;Katherine T. Wolcott, Executive Secretary.Cover photograph by Chuck Strozier.Ford Foundation AnnouncesPopulation ControlResearch GrantThree University programs relating to popu­lation control research, action, and infor­mation have been awarded $1,638,223from the Ford Foundation.The three grants are among 28 totaling$9,871,910 announced by the Ford Foun­dation. The grants include:-$929,995 for partial support of a five­year program of training in reproductivebiology and research in ovulation, contra­ception, and implantation directly relevantto fertility control. The research will beunder the direction of Dr. Frederick P.Zuspan, the Joseph Bolivar De Lee Pro­fessor and Chairman of the Department ofObstetrics and Gynecology. It ranges fromimproved intra-uterine devices to the roleof steroid hormones in the developingovarian follicle.-$418,770 for research that may lead todevelopment of antigens to control "up­take receptors," proteins in the uterine cellthat attract estrogen. This research is un­der the direction of Elwood V. Jensen,Ph.D. '44, the American Cancer Society­Charles Hayden Foundation Research Pro­fessor in the Ben May Laboratory for Can­cer Research, and Professor of Physiology.-$189,458 for a study of the effect of oralcontraceptives on the epithelium in theuterine cervix under Dr. George L. Wied,the Blum-Riese Professor of Obstetrics andGynecology, Professor of Pathology andDirector of Exfoliative Cytology.Jensen's research may lead to the develop­ment of immunological means of control­ling implantation by inactivating the pro­tein in the uterine cell that attracts estro­gen. Estrogen is necessary for the growthof certain types of uterine cells.Jensen's previous research has shown thatestrogen, necessary for the growth of cer­tain types of cells in the uterus, enters thecell and is attracted to a protein therecalled the "uptake receptor." If these re­ceptors could be inactivated, uterine cellgrowth would be inhibited and the uterinechanges necessary for implantation and de­velopment of the fertilized egg would beprevented. It is theoretically possible that these up­take receptors could be controlled by im­munological means. But before an antigencan be developed for this purpose, the re­ceptors must be isolated so that their chem­ical, physical, and immunological proper­ties can be identified. Jensen's researchwill seek to isolate uptake receptors andstudy their characteristics.Since cancer cells in the uterus may pro­liferate in a similar manner, control ofuptake receptors is also of interest to can-cer specialists. .Dr. Zuspan is author of more than 40 re­ports on clinical medicine and research andhas contributed to three medical textbooks.Before joining the faculty of The Univer­sity of Chicago in 1966, he served aschairman of the department of obstetricsand gynecology at the Medical College ofGeorgia in Atlanta.Jensen received his A.B. degree from Wit­tenberg College and his Ph.D. degree fromThe University of Chicago. He joined TheUniversity of Chicago faculty in 1947 asan Assistant Professor, was named Profes­sor in 1960 and the American Cancer So­ciety-Charles Hayden Foundation Re­search Professor in 1963. He has writtenmore than 80 articles for scientific journals.Dr. Wied, an authority on exfoliative cy­tology, the study of cells shed from thesurface of various organs, received his M.D.degree from Charles University, Prague,Czechoslovakia, in 1945. He became di­rector of cytology at the Free Universityof West Berlin in 1948. He joined TheUniversity of Chicago faculty in 1953.Dr. Wied is editor of Lying-in: The Tour­naI of Reproductive Medicine, and ACTACytologica, The J ournal of Exfoliative Cy­tology. He was president of the AmericanSociety of Cytology in 1966-67 and wasrecipient of the Maurice Goldblatt Cytol­ogy Award in 1961. Lewontin ElectedPresident ofEvolution SocietyRichard C. Lewontin, Professor of Biologyand the Committee on Mathematical Biol­ogy, has been designated president-electof the 1200-member Society for the Studyof Evolution.The international professional society wasfounded in 1939. Its membership includesgeneticists, taxonomists, anthropologists,biologists, paleontologists, and others con­cerned with organic evolution.Earlier this year Lewontin was elected tomembership in the National Academy ofSciences in recognition of his individualdistinguished and continuing achievementsin original research in evolution and popu­lation genetics.Lewontin is a fellow of the American Acad­emy of Arts and Sciences and a member ofthe board of directors of the American Eu­genics Society. He is editor of The Ameri­can Naturalist, associate editor of DelZuchter, and a member of the editorialboard of Biochemical Genetics. He is also afellow of the University's Center for PolicyStudy.He was appointed a Professor at the Uni­versity in 1964 and was named AssociateDean of the Division of the Biological Sci­ences and The Pritzker School of Medi­cine in 1966. This year, he returned tofull-time teaching and research. In thespring of 1967 he served as a visiting dis­tinguished professor at Syracuse University.Richard C. Lewontin2Dr. Resnekov AdvocatesTransplant RegistryAn international registry to collect infor­mation on the progress of all heart trans­plant patients has been advocated by Dr.Leon Resnekov, Associate Professor ofMedicine in The Pritzker School of Medi­cine.He pointed out that although nearly 100operations have been performed, almost noinformation is available on the progress ofpatients following the initial surgicalperiod."It is time," he commented, "for a scien­tific appraisal of the success of such surgeryto determine if it is worthwhile from thepatient's point of view."He emphasized that the lack of informa­tion is not due to any attempt to conceal,but is the natural result of the operationsbeing performed by different teams in dif­ferent locations.If an international registry were estab­lished, he noted, physicians would be ableto assess the possibility of successful resultsin other candidates for the operation.Dr. Resnekov also called for an accelerated,two-pronged research program directed to­ward:-Developing a method of preserving cir­culation in a heart transplant candidate un­til a suitable donor can be found.-Finding a way to preserve organs forlonger periods of time. At present, suchpreservation is a matter of hours, at best.This research, he noted, will cost millionsof dollars but is necessary to take hearttransplantation out of the realm of experi­mental surgery.The surgical costs of such an operation areexpensive, ranging from $30,000 to $40,000per operation. And, because transplantationcannot assure the patient long-term sur­vival, surgeons select recipients from "hope­less cases." Dr. Resnekov emphasized he favors contin­uation of heart transplant work in conjunction with the research program that, hope­fully, will make such surgery a viable treat­ment method.Potential candidates for heart transplants,as listed by Dr. Resnekov, include fivegroups. They are:1. Patients with very severe coronary arterialdisease for whom no palliative measures arepossible. This group usually is over the ageof 40.2. Patients with primary muscle disease ofthe heart, usually of unknown origin andgrouped under the general heading of car­diomyopathy. These patients usually arerelatively young. Dr. Resnekov indicatedthere is a small amount of evidence that pa�tients in this group may develop the samedisease process in a new organ.3. Patients, usual1y children, with severeand congenital heart disease, not amenableto ordinary surgical techniques.4. Patients with very severe multi-valve dis­ease. Those in this group also tend to havesevere heart muscle strain and secondarychanges in the lung so it may be necessaryto transplant at least one lung. (Dr. Resne­kov noted that there have been no success­fullung transplants in humans thus far.)5. Children with severe rheumatic fever orother disease affecting the heart.As to the question of how a potential re­cipient is selected, Dr. Resnekov said, atThe University of Chicago such decisionsare made by a committee.An attending physician who believes atransplant is indicated brings the detailsof the case before a committee of twosenior faculty cardiologists and a senior fac­ulty internist. They study the case and ex­amine the patient. If a transplant seemsfeasible, the surgical team is informed andasked to give an opinion. Dr. HosobuchiHonored byNeurological AcademyDr. y oshio Hosobuchi, Chief Resident inNeurosurgery and Instructor of Neuro­surgery in The Pritzker School of Medicine,has been given The American Academy ofNeurological Surgery senior award for hisresearch linking viruses to certain experi­mental brain tumors.The award is presented annually to an out­standing neurosurgical resident who showspotential as a future leader in the specialty.Dr. Hosobuchi submitted a report to theAcademy on his research titled "The Cell­Free Transmission of Hydrocarbon InducedHamster Glioma with Demonstration ofVirus Particles in the Precancerous Tissue."For his research in this field, Dr. Hoso­buchi was also awarded the 1967 PeterBassoe award of the Chicago NeurologicalSociety.Working with Dr. John F. Mullan, Profes­sor and Head of Neurosurgery in the De­partment of Surgery, Dr. Hosobuchi hasevolved a method of rapid production ofexperimental tumors in hamsters. In thecourse of these tumors' growth, the re­searchers have observed virus particles inthe reacting cells.These virus particles have been concentrat­ed in the cell-free extract and tumors havebeen induced in hamsters by the extract.Thus, for the first time, it has been shownthat chemically induced experimental braintumors are associated with and mediatedby virus particles.These experiments support a growing bodyof experimental evidence relating viruses tocancer.Dr. Hosobuchi was born in Tokyo. Hewas graduated from the University of Utahin 1960 and earned an M.D. and M.S.from the Stritch School of Medicine ofLoyola University in Chicago in 1964. Hejoined the University Hospitals staff as asurgical intern in July, 1964.3Other Alumni Perform TransplantsTwo- other alumni have also participatedin recent heart transplant surgery. Dr. Or­mand C. Julian, '43, chairman of surgeryat Presbyterian-St. Luke's Hospital, Chi­cago, took part in Chicago's first successfulheart transplant operation, the world's103rd transplant.Dr. David M. Hume, '43, professor andchairman of surgery at the Medical Collegeof Virginia, Richmond, performed the six­teenth heart transplant. He has conductedextensive research on organ transplantationand was among the earliest physicians toattempt a kidney transplant. He and hisassociates have performed more than 140kidney transplants since 1962.Surgical Team Performs University'sFirst Heart TransplantA University of Chicago heart transplantteam performed its first human heart trans­plant Christmas Day, December 25.The team was headed by Dr. C. FrederickKittle, '45, Professor of Surgery and Chiefof the Section of Thoracic and Cardiovas­cular Surgery.The transplant operation began at 8: 30P.M. The recipient died at 1: 30 A.M. De­cember 26 after being sustained by ·inter­mittent use of the heart-lung machine.Recipient was an eight-day-old boy, DavidWhippie, whose parents, Paulette andJames Whippie, live in Harvey, Illinois.The child was admitted to Wyler Chil­dren's Hospital on December 20 sufferingfrom numerous congenital heart defectsnot correctable by any known surgical pro­cedure.The donor was two-day old Joseph Or­bochta who died Wednesday evening, De­cember 25, of birth defects not involvingthe heart.Members of the surgical team, in additionto Dr. Kittle, were Dr. Robert L. Replogle,Assistant Professor of Surgery, and Dr.Magdi H. Yacoub, Instructor in Surgery.Anesthesiologists were Dr. Adel A. EI-Etr,Assistant Professor of Surgery (Anesthesi­ology), and Dr. M. Ramez Salem, Assist­ant Professor of Surgery (Anesthesiology).4Two Named ProfessorshipsAnnouncedThe University has announced appoint­ments to two major named professorshipsin the Division of the Biological Sciencesand The Pritzker School of Medicine.Dr. Joseph B. Kirsner has been namedLouis Block Professor of Medicine, a chairhonoring the late Louis Block, who waspresident of the Blockson Chemical Com­pany, Joliet, Illinois. He bequeathed fundsfor the Louis Block Fund for Basic Re­search and Advanced Study, established in1956 to support the Divisions of BiologicalSciences and Physical Sciences.Dr. Humberto Femandez-Moran has beenappointed A. N. Pritzker Professor of Bio­physics. The Pritzker family of Chicagohas contributed $12 million to supportthe medical school and to create four en­dowed chairs.Dr. Joseph B. KirsnerDr. Joseph B. Kirsner joined the faculty ofthe University in 1935, after earning hisM.D. from Tufts University School ofMedicine, Medford, Massachusetts, in1933. Since then, he has remained on thefaculty in the Department of Medicine; in1942, he received his Ph.D. in BiologicalSciences from the University.Dr. Joseph B. KirsnerAuthor or co-author of approximately 400publications dealing with various clinicaland experimental problems in gastroenter­ology, Dr. Kirsner's major clinical and re­search interests include peptic ulcer andgastric secretion, regional enteritis and ul­cerative colitis, and cancer of the gastro­intestinal tract.Over the years, the list of his professionalmemberships, and of his contributions tomedical committees, from local to national levels, has grown to impressive proportions.Currently, Dr. Kirsner is a member of 15professional societies and on the editorialboards of four medical publications.He is past president of the American Gas­troenterological Association, the AmericanGastroscopic Society, the Chicago Societyof Internal Medicine, and the Jackson ParkBranch of the Chicago Medical Society.Dr. Humberto Fernandez-MoranDr. Humberto Fernandez-Moran, a nativeof Venezuela, came to The University ofChicago in 1962. Internationally knownfor his work in electron mircoscopy, he de­veloped the diamond knife nearly 20 yearsago when he was a research fellow at theNobel Institute in Stockholm. His knife,capable of cutting starch into its compo­nent sugars, enabled scientists to study thetiniest organic details under an electronmicroscope, and opened up the field ofelectron microscopy.Dr. Humberto Fernandez-MoranRecently, Dr. Fernandez-Moran has con­ducted research in the field of subminia­turization, which he feels holds greatpromise.Born in Maracaibo, Venezuela, in 1924,he was educated in Germany and receivedhis M.D. from the University of Munich.He returned to Venezuela to obtain hislicense to practice, and, while there, earneda second M.D. degree from the Universityof Caracas.Dr. Fernandez-Moran has represented Ve­nezuela in several international confer­ences, and in 1958, served as minister ofeducation for his country. Perspectives JournalWins AwardAn unconventional and highly respectedmedical quarterly published by the Uni­versity has received the American MedicalWriters Association's 1968 Honor Awardfor Distinguished Service in Medical J our­nalism.In presenting the award, the Associationdescribed the quarterly Perspectives inBiology and Medicine as a "free-wheelingvehicle for speculative essays, sharp po­lemics, engaging biography, good poetryand philosophical reflection."The quarterly was also honored with a ci­tation from the Association in 1964.Perspectives is edited by Dwight I. Ingle,eminent endocrinologist and physiologistand Professor of Physiology at the Univer­sity.Ingle is known primarily for establishingthe fact that cortisone is biologically active.He was also the first to experimentallydemonstrate that adrenal atrophy occurs inresponse to overdosage with cortisone orother steroids, and the first to experimen­tally demonstrate steroid diabetes. He alsois known for his research on the role ofthe adrenal cortex in causing adaptationdiseases.He started Perspectives in 1957 in the be­lief that scientific writing should not bestilted, ponderous or dull."Authors," he said, "are encouraged to usean informal, humanistic style which pre­serves the warmth, excitement and colorof the life and medical sciences."The essays published in Perspectives arewritten primarily for medical scientists,practicing physicians and surgeons, biolo­gists, and students of biology and medi­cine. However, its readers include intelli­gent laymen ranging from high schoolstudents to English teachers,Published by The University of ChicagoPress, Perspectives boasts an advisory boardthat includes Nobel Laureates Francis H. C.Crick, Sir John Eccles, Albert Szent­Gyorgyi, Arne Tiselius, and others.5AppointmentsAnesthesiologyDr. Merel H. Harmel has been appointedProfessor of Surgery (Anesthesiology) andChief of the Anesthesiology Section of theDepartment of Surgery.Dr. Harmel has been professor and chair­man of the department of anesthesiologyat the Downstate Medical Center of theState University of New York since 1952.He succeeds Dr. Duncan A. Holaday; '43,who is now professor of surgery (anesthe­siology) at the University of Miami (Flor­ida). School of Medicine.Dr. Merel H. HarmelDr. Harmel holds B.A. (1934) and M.D.(1943) degrees from the Johns HopkinsUniversity School of Medicine. He hasserved on the faculties of Johns Hopkins( 1944-1946), the University of Pennsyl­vania (1946-1948), and Albany MedicalCollege (1948-1952).BiologyDaniel H. Janzen and Michael Espositohave been appointed Assistant Professorsin the Department of Biology.Esposito earned his B.S. degree cumlaude from Brooklyn College in 1961 andhis Ph.D. from the University of Wash­ington, Seattle, in 1967. His research dealsprimarily with biochemical and geneticregulation of yeast. He has served as ateaching fellow in general biology, inte­grated science, and botany at BrooklynCollege and general genetics at the Univer­sity of Washington. From 1962 to 1967he was a United States Public Health Service genetics trainee at the Universityof Washington. From 1967 to 1968 he wasan N.I.H. postdoctoral fellow in the Mo­lecular Biology Laboratory of the U niver­sity of Wisconsin.Janzen received his B.S. from the Univer­sity of Minnesota in 1961 and his Ph.D.from the University of California at Berke­ley in 1965. He is primarily interested inecological research on' the interrelationshipof plants and animals. He has served as acourse co-ordinator for the Organizationfor Tropical Studies in Costa Rica (Feb­ruary to August, 1965) and co-ordinatorof the University of Kansas-Universidaddel Oriente, Venezuela, Program from Sep­tember, 1965, to June, 1966. For the lastthree years, he was an assistant professor ofentomology at the University of Kansas.Obstetrics and GynecologyDr. Robert E. Cleary has been appointedAssistant Professor in the Department ofObstetrics and Gynecology.Dr. Cleary earned his M.D. at the Univer­sity of Illinois College of Medicine in Chi­cago in 1962. He served his internship andresidency at St. Francis Hospital, Evans­ton, Illinois.From 1966 to 1968, he was a PostdoctoralNational Institutes of Health Fellow inEndocrinology in the department of ob­stetrics and gynecology at the Universityof Washington, Seattle. Dr. Cleary will de­velop the gynecologic-endocrinology andinfertility service at Chicago Lying-in Hos-pital. .PathologyWard R. Richter has been appointed As­sociate Professor of Comparative Pathol­ogy.Rich ter has been head of the section oncellular pathology and electron microscopyat Abbott Laboratories, North Chicago,I11inois, and an associate professor of pa­thology at Iowa State University. He holdsD.v.M. and M.S. degrees from Iowa StateUniversity.A specialist in electron microscopy andcellular ultrastructure. he has also workedextensively in toxicology and laboratory animal pathology. He is especially inter!ested in diseases of laboratory animals andin comparative pathology.PsychiatryTen persons have been appointed to thefaculty of the Department of Psychiatry.Dr. Tad E. Dyrud has been appointed As­sociate Professor of Psychiatry and Direc­tor of Clinical Services. A psychoanalystand psychotherapist who was engaged intherapy, teaching and research in Wash­ington, D.C. for the past 20 years, he isespecially concerned with new programs todeliver efficient patient care to children aswell as to adults.He earned his M.D. from the Johns Hop­kins University in 1945, took his intern­ship in surgery and psychiatry at JohnsHopkins, and served psychiatric residenciesat Chestnut Lodge in Rockville, Maryland,and Spring Grove State Hospital, Catons­ville, Maryland.Dr. Pieter DeVryer will serve as AssociateProfessor of Child Psychiatry and Directorof the Nicholas J. Pritzker Children's Cen­ter and Hospital. A psychiatrist and childpsychoanalyst, he earned his M.D. in 1951from the University of Leyden MedicalSchool of the Netherlands. He took hisinternship and psychiatry training at Rot­terdam Municipal Hospitals, and contin­ued his training in the United States.He is a graduate of the Institute of Psycho­analysis in Chicago, and for the last sixyears has served on the staffs of Presby­terian-St. Luke's Hospital, and the Uni­versity of Illinois Medical Center, both inChicago.Dr. John N. Chappel joins the faculty asAssistant Professor of Psychiatry. He hasbeen actively engaged in research on drugabuse and has extensive experience in com­munity medicine.He earned his M.D. degree from the Uni­versity of Alberta in Canada in 1960, andserved his internship at Royal AlexandriaHospital in Edmonton, Alberta. A medicalofficer for CARE-MEDICO in Malaysiafor two years, he has just completed hisresidency in psychiatry at The Universityof Chicago.6Israel Goldiamond has been appointed Pro­fessor of Psychiatry and Psychology. For­merly a professor at Johns Hopkins andhead of the Institute of Behavioral Re­search, he is widely known for his researchin signal detection therapy, operant con­ditioning, programmed learning and be­havior therapy, and has devised a basicapproach known as behavioral analysis.He earned his Ph.D. in experimental psy­chology from The University of Chicagoin 1955. Author of more than 30 booksand papers, he has served on the faculty atSouthern Illinois University, Arizona StateUniversity, and Washington School of Psy­chiatry.Philip S. Holzman has been 'appointed Pro­fessor of Psychiatry and Psychology. Anexperimental psychologist and psychoana­lyst, he has done extensive research in per�ception. Most recently he has been a train­ing analyst at the Topeka Institute forPsychoanalysis and a research psychologistat the Menninger Foundation, where hedeveloped progra�ns of research and train­ing for psychiatrists and psychologists.He earned his Ph.D. from the Universityof Kansas, Lawrence, in 1952 and serveda four-year internship at the Winter Vet­erans Administration Hospital in Topeka.Dr. Patrick Hughes has been named As­sistant Professor of Psychiatry. He has con­ducted major research on problems of cornpulsive narcotics use and its relation tourban problems, and has been chief projectconsultant for the National Institute ofMental Health. He will be Clinical Di­rector of the Department's Drug AbuseRehabilitation Program.He earned his M.D. at the University ofPittsburgh in 1960, and took his intern­ship in medicine at Stanford Medical Cen­ter, Palo Alto, California, and his residen­cy in psychiatry at Columbia PresbyterianMedical Center, New York City. Dr. Herbert Melzer has been appointedAssistant Professor of Psychiatry. He hasbeen a clinical associate in the Laboratoryof Clinical Science of the National Insti­tute of Mental Health, and is conductingresearch on blood enzymes which occur inpsychosis.He earned his M.A. in biochemistry atHarvard University and M.D. from YaleUniversity. He took his internship in medi­cine at St. Luke's Hospital in New YorkCity, and his residency in psychiatry atMassachusetts Mental Health Center, Bos­ton. He. has served on the staffs of thePeter Bent Brigham Hospital, Boston, andthe Washington School of Psychiatry.Charles Schuster has been appointed As­sociate Professor of Psychiatry. He hasconducted research at the University ofMichigan, Ann Arbor, on the applicationof the techniques of behavioral psychologyto the analysis of problems of drug abuseand drug addiction.He earned his Ph.D. from the Universityof Maryland, College Park, and has servedon the faculties of the University of NewMexico, Temple University, the Univer­sity of Maryland, and the University ofMichigan.John R. Thomas has been appointed As­sistant Professor of Psychiatry and Psy­chology. He earned his Ph.D. from theUniversity of Maryland in 1962, and hasserved on their faculty. He has writtenmore than a dozen articles dealing withconditioning and the experimental modifi­cation of behavior.Thomas has been on the research staff ofthe Institute of Behavioral Research, andis a member of several professional organ­izations, including the American Psycho­logical Association, and the American As­sociation for the Advancement of Science.Dr. Eberhard H. Uhlenhuth has been ap�pointed Associate Professor of Psychiatryand Director of Outpatient Section. Hehas conducted extensive research in be­havior change and psychology, and hasbeen a faculty member of the Johns Hop­kins University. He earned his M.D. from Johns Hopkinsin 1951, interned at King County Hos­pital, Seattle, Washington, and served hispsychiatric residency at Johns Hopkins. Heis known from his study of placebo re­sponse and his research on therapy con­ducted in psychiatric outpatient clinics.Zoller Dental ClinicDr. Robert C. Likins has been named Di­rector of the Walter G. Zoller MemorialDental Clinic of The University of Chi-Dr. Robert C. Likinscago. Formerly the Dental Director of TheNational Institute of Dental Research, Dr.Likins, '46, holds both B.A. and D.D.S.degrees from Kansas City University, Kan­sas City, Missouri. He had been with theNational Institute of Dental Research ofthe National Institutes of Health for 22years.He is known for his work both as an ad ..ministrator and as a research investigator inmineral metabolism and the basic mecha�·nism of calcification.7Aspirin may contribute to the formation ofgastric ulcers.This is the report of Dr. Rene Menguy,Professor and Chairman of the Depart­ment of Surgery, and Dr. Martin H. Max,Research Associate in the Department ofSurgery.According to the report, their U.S. PublicHealth Service supported investigation hasshown that aspirin, taken orally, significant­ly impairs the ability of cells to produce aprotective mucous coating.More recently, research with dogs hasshown that aspirin administered so that itdoes not come into contact with the stom­ach lining causes an increased loss of cellsfrom the lining.This increased loss of cells, they reported, isobviously due to the action of circulatingaspirin and not to a direct action of aspirinon the mucosa. The decrease of cells notcompensated for by an increase in cell re­production could lead to ulcer formation.Dr. Menguy further pointed out that theseeffects of aspirin on the gastric mucosa can­not be com bated by altering the way inwhich aspirin is administered, such as en­teric coating or buffering. The effects aredue to absorbed, circulating aspirin.The importance of the problem can beseen in the fact that aspirin is consumed atthe rate of over 20,000,000 pounds per yearin the United States.According to Dr. Menguy, estimates arethat aspirin is the responsible cause in oneout of every seven patients hospitalizedwith gastrointestinal bleeding.The source of such bleeding in patientshaving consumed aspirin is a superficial,erosive, and hemorrhagic gastritis.He said the lining of the stomach is usual­ly covered by a large number of tiny ulcera­tions. In most cases these heal spontane­ously as bleeding stops, but sometimessurgery becomes necessary to arrest thehemorrhage.In the past, damage to stomach lining fromaspirin has been assumed to result from adirect irritation of partially-dissolved aspirinon the gastric mucosa.Aspirin May Contributeto Ulcer FormationHowever, this explanation is virtually com­pletely invalidated by Dr. Menguy's ob­servations that aspirin can cause the samegastric mucosal injury if administered so itcannot come in contact with the stomachlining. In addition, as aspirin does not in­crease acid secretion by the stomach, as­pirin-induced hyperacidity cannot be a fac­tor.Dr. Menguy's research indicates that as­pirin impairs the mechanisms normally re­sponsible for protecting stomach liningfrom its own acid. -These protective mechanisms consist of alayer of mucus constantly increased by thecells lining the stomach and by the abilityof these cells to renew themselves.Dr. Menguy's research has demonstratedthat aspirin does interfere with this cellproduction.Biological Sciences DivisionAffiliates with Michael ReeseA proposal has been approved for theaffiliation of the Michael Reese Hos­pital and Medical Center with theDivision of the Biological Sciencesand The Pritzker School of Medicineof the University. The approved pro­'posal provides for mutual assistanceand cooperation between the Medi­cal Center and the Division of theBiological Sciences and The PritzkerSchool of Medicine in areas of, com­mon concern to achieve the best pos­sible patient care, medical education,and research.It provides for a cooperative arrange­ment but does not call for the mergerof the facilities of the two institu­tions.The joint affiliation proposal wasworked out by representatives of thetwo institutions over the past eigh­teen months. Kluver ReceivesAchievement A wardHeinrich K1iiver, Sewell L. Avery Distin-Iguished Service Professor Emeritus of Bio­logical Psychology, has been named a 1969recipient of one of medicine's most promi­nent honors, the Modern Medicine Dis­tinguished Achievement Award.Announcement of Kliiver's selection, withnine other physicians and medical educa­tors, appeared in the January 13 issue ofModern Medicine, a national medical jour­nal which sponsors the awards annually.Nominations come from deans of U.S.medical schools, leaders of medical organi­zations, physician-readers, and physicianmembers of the Journal's editorial faculty.Kliiver, who joined the University in 1933,is cited for "wide-ranging work in manyaspects of biological psychology, includingoutstanding research on neural develop­ment and function." In 1964, he receivedthe Gold Key of the University's MedicalAlumni Association, in recognition of hiscontributions to the medical school and tothe University.Born in Germany, he received his Ph.D.degree at Stanford University in 1924. Hehas been cited in recent years as "one ofthe truly great psychologists of this cen­tury," and the "world's most distinguishedexperimental biological psychologist."Former Intern HonoredA former intern in surgery at the Univer ...sity hospitals and clinics, Dr. Marvin D.Siperstein, '48-'49, also won the covetedhonor this year. Now a professor of inter­nal medicine at the University of TexasSouthwestern Medical School at Dallas,Dr. Siperstein has conducted research onthe basic relationship between cell choles­tergenesis control and cancer, and on thecontrol of fatty acid synthesis in diabetes.He credits Dr. Lester Dragstedt, '21, Chair­man of Surgery during his internship, forencouraging him to pursue his researchinterests.Dr. Menninger NamedIncluded among the ten physicians namedto the awards was Dr. Karl Menninger,internationally known psychiatrist and Vis­iting Professor of Psychiatry at The Uni­versity.8'There are drugs and other treatments which can suppressthe white blood cells," said Dr. Peterson. "But they leave thebody vulnerable to attack by a wide variety of infections. Thisattack by infection is the primary problem of an organ trans­plant recipient following the operation."According to Dr. Peterson, there are various degrees of com­patibility between human tissues. Thus, by categorizing whiteblood cell response and using a computer, it is possible toreduce the risk by finding a recipient whose tissues are com­patible with those of an available organ."There will still be a need for the use of some drugs to sup­press the response," he said. "But if the tissues are close intype, the drugs can be reduced and leave the white blood cellsfunctioning sufficiently to protect from infection."Dr. Peterson pointed out that exact tissue typing is impos­sible, but categories of compatibility and non-compatibilitycan be established.The genetic problem involved in tissue typing is most strikingin a given family.Dr. Peterson said the chances are one in four that a givenbrother or sister will be in the same general tissue type as apotential kidney recipient. This can be determined by themethod being used in the program.By the same token, however, the odds are one in four thata given brother or sister will be a tissue type totally incom­patible for a successful transplant. Thus, he said, "a randommatch in a family can be the worst possible match."The problem in controlling the immune response, said Dr.Peterson, is that it is not a simple one-step action of the body,but a series of related changes leading to the release of at leastnine enzymes. These toxic enzymes cause a number of de­structive changes, such as the liberation of histamine whichleads to blood leakage.In practice, the immune response can be interfered with atvarious points in the process. Drugs such as cortisone andimuran can block cell replication and DNA synthesis, de­stroying or neutralizing white blood cell response. Even puri­fied cobra venom can be used to block the immune response,Dr. Peterson said.In addition to drugs, research on animals has shown that con­trolled doses of antigen or foreign tissue can build up a toler­ance to the tissue and lessen the chance of rejection.Researchers Seek To Control Immune ResponseA young man receives a transplanted kidney or heart.The surgical procedure is highly successful and the struggleto keep the recipient's normal body mechanism from reject­ing the organ begins.Normally, immunity-suppressing chemicals are given. Thehope is that dosage of chemicals will not have to be so highthat the body is no longer capable of protecting itself fromany foreign tissue-such as common viruses-which can be­come deadly if unchecked.A number of University of Chicago research scientists andclinicians are looking for ways to understand and control theimmune response so rejection will no longer be a major hazardof transplant surgery.Computers and Tissue TypingIn one project now being established, part of the problemwill be solved by having computers-not doctors-decidingwhich of several individuals waiting for a transplant will re­ceive an available organ.Dr. Raymond D. A. Peterson, Associate Professor of Pedi­atrics in The Pritzker School of Medicine and a member ofthe staff of LaRabida-University of Chicago Institute, saidthe computerized program will be a joint effort of three uni­versities: The University of Chicago, the University of Illi­nois, and the University of Wisconsin.The program involves the establishment of tissue typing lab­oratories in all five medical schools and the leading teachinghospitals in Chicago, Milwaukee, and Madison, Wisconsin.Using 58 basic tissue types, an organ will be classified andthe data fed into a computer. The computer will have fulltissue typing data on potential recipients and clinical infor­mation. It will match the organ to the most compatible wait­ing recipient.This will eliminate the need for a physician to decide whowill receive an organ and will improve the likelihood of asuccessful transplant.Dr. Peterson said it is well known that the human body tendsto reject any foreign tissue. In effect, the tissue, such as thatof a transplanted kidney, is attacked by blood antibodies andwhite blood cells.I t is, however, the white blood cells or leucocytes that causethe primary damage to a transplant by attacking its cells justas they would attack a virus.9A method involving the injection of foreign antibodies toprotect or coat the foreign tissue is also being studied andhas been used successfully at The University of Chicago onanimals.A major problem in setting up a tissue typing program, Dr.Peterson said, is that human antiserum is necessary to typeincoming tissue. In red blood cell typing, there are relativelyfew easily identifiable blood types which can quickly betreated against animal antiserum.For white blood cell typing, however, the need for humanantisera has led researchers to try to develop a readily usableantiserum using blood from a woman after childbirth. Sucha woman has developed an active antiserum as a result ofhaving to produce antibodies to deal with the tissue of thefetus with which she is not directly compatible.Dr. Peterson has also been experimenting with the possibilityof son-father antibody injections to produce an antiserum insufficient quantity to be used for tissue typing.The establishment of the tissue typing program is sponsoredin part by the Otho S. A. Sprague Memorial Institute andthe Variety Clubs Research Center of LaRabida.A Non-Drug TechniqueMeanwhile, a medical research team at The Pritzker Schoolof Medicine has developed a technique to specifically sup­press the body's immune mechanism which does not involvechemical treatments.The technique can prevent the body from rejecting a trans­planted organ, while preserving the immune reaction respon­sible for fighting infections.The technique is the culmination of eight years of researchsupported by the National Institutes of Health. The basicwork on mechanisms regulating the immune response wascarried out by Dr. Donald A. Rowley, '49, Associate Profes­sor of Pathology, Dr. Frank W. Fitch, '53, Professor of Pa­thology, and pathology graduate students.The application and further extension of this work to organtransplantation was carried out by Dr. Frank P. Stuart, As­sistant Professor of Surgery, and Dr. Tatsuo Saitoh, ResearchAssociate in Surgery, in collaboration with Dr. Fitch.They explained that animals respond to foreign material orantigen in two ways: by manufacturing antibodies, which areprotein molecules in the blood, and by producing a new kind of white blood cell. Different antibodies or white blood cellsare produced in response to each antigen and these react onlywith their antigen.Antibodies are responsible for protection against most infec­tions. The white blood cell response, however, can also attacktransplants. A transplant, in fact, causes both responses, butonly the white blood cell type results in rejection of a trans­planted organ.The new technique developed at The Pritzker School ofMedicine of The University of Chicago has the advantage ofspecifically suppressing the cell type response to the trans­plant without affecting the reaction to other antigens.The method is based on two principles. First, antibody regu­lates or controls the immune response to its antigen. In asense, antibody acts as a "feedback" control to limit the re­sponse to the antigen. When antibody produced in one indi­vidual is given to another who has not been exposed previ­ously to the antigen, the immune response is markedly sup­pressed.Second, antigen can be given so that an antibody rather thana cell type of response predominates.In practice, rats are treated with an antidonor antibody andwith donor antigen at the time they receive a kidney trans­plant. No additional treatment is required. The transplantedkidney survives indefinitely and functions normally. The ani­mal's response to infectious organisms is not affected.In effect, the antibody partially suppresses both the antibodyand cell type responses to the transplanted kidney. The donorantigen directs the host's response so that only harmless anti­body against the graft is formed.Untreated rats invariably reject kidney transplants in less thana month. None of the 19 treated rats in The University ofChicago study has rejected its kidney. Several of these animalshave now survived for a year.If the treatment can be adapted to use in man, the long-termsurvival of patients receiving such transplants as kidney, heart,or lung may be achieved without the use of potentially dan­gerous drugs.Antibodies Causing DiseaseAt the same time, another researcher has found that part ofthe body's normal protective system can cause successfullytransplanted kidneys to develop the recipient's original dis­ease.10A new immunologic technique which preserves the pa­tient's total immune response while suppressing trans­plant rejection was developed by a University researchteam (below, 1. to r.) Dr. Tatsuo Saitoh, Dr. FrankFitch, Dr. Donald Rowley, Dr. Thomas Logio, and Dr.Frank Stuart. Researchers Fitch, Stuart, and Rowley(left) announced the results of their work at a pressconference this winter.11This has been particularly evident in transplants involvingidentical twins when the original disease was glomerulo­nephritis, a common and often fatal kidney disease.Extensive experiments at the University indicate that bloodantibodies are responsible for one type of glomerulonephritis,which is characterized by inflammation in the glomeruli orcoils of tiny blood vessels in the tubes carrying urine from the,kidneys.Human lung or glomeruli tissues contain specific antigens,substances which induce the formation of antibodies to reactwith them when they are introduced into a new body. Someof these antibodies, the so-called autoantibodies, inadver­tently attack the body's own kidney and damage it, accordingto Dr. Raymond W. Steblay, '52, Research Associate (Assist­ant Professor) in Pathology in The Pritzker School of Medi­cme.Dr. Steblay's experiments with sheep and other animals andhis observations of the human disease have provided the firstevidence that such autoantibodies can cause a specific diseaseand tissue damage.To support these concepts, Dr. Steblay has injected sheepwith human glomeruli tissue and Freund's adjuvant, a chemi­cal compound that increases the body's immunologic responseto foreign substances (antigens). The antibodies in the sheepbegan to attack the injected tissue but some of them alsoreacted with the sheep's own healthy kidney to cause glo­merulonephritis.To demonstrate the disease-producing capacity of the bloodantibodies, Dr. Steblay showed that artery-to-artery cross­circulation of blood can transfer the disease from a sick ani­mal to a healthy one in as little as four hours. If the sickanimal's kidneys are removed, the healthy animal's kidneysmay develop even more severe disease because the antibodiesin the blood begin to concentrate on the available kidney andare no longer absorbed by the diseased kidney.'Therefore," said Dr. Steblay, "it might be expected thattransplanted human kidneys, permanently implanted, may bean even more vulnerable target for host autoantibodies againsthuman glomerular basement membrane in the kidneys. Thisis particularly true where the host immune response has notbeen effectively suppressed, such as in grafts in identicaltwins."He cited one case in which a transplant took place when Dr. Raymond D. A. Peterson is working to establish a program with sev­eral midwestern universities to fully computerize tissue-typing for futuretransplant operations. A computer would decide the most compatibledonor-recipient match.known antibodies were present in the recipient-and thetransplanted kidney soon became diseased.According to Dr. Steblay, autoantibodies can readily be iden­tified in blood and should be sought before human kidneytransplants are performed. "If the autoantibodies are presentin the recipient," he said, "the healthy kidney is in dangerof being attacked and diseased. The transplant should be de­layed until the antibodies can be suppressed."To confirm these observations, Dr. Steblay has transferredglomerulonephritis from a diseased sheep into a healthy sheepby means of cell-free serum containing autoantibodies. Inaddition, he has isolated autoantibodies from the kidneys ofdiseased sheep, injected them into healthy lambs, and pro­duced the disease.12Dr. Steblay also has observed that injections of normal sheepkidney and Freund's adjuvant into a healthy sheep can formautoantibodies which damage the healthy sheep kidney.These findings led him to consider a second possible mecha­nism by which the grafted kidney may develop glomerulo­nephritis-the healthy transplanted kidney might initiate theantibody response which can lead to glomerulonephritis. Hesaid there is some evidence to suggest this can occur in humantransplants and the full extent of this possibility should beexplored.Assisted by Ulrich Rudofsky, Dr. Steblay is conducting hisresearch under a grant from the National Institutes of Health.Thus, according to Dr. Steblay, a transplanted kidney maydevelop glomerulonephritis for two reasons:I) The recipient's original disease may be glomerulonephri­tis, a disease resulting from autoantibodies which attack theanimal's own kidney. If these autoantibodies continue to beformed by the recipient before or after grafting, the healthygrafted kidney may be attacked by these antibodies andundergo a recurrence of the recipient's original disease. Thegrafted kidney did not provoke the disease in this case, butwas merely an innocent target for the preformed autoanti­bodies in the recipient. Both the cross-circulation transfersand one case personally observed by Dr. Steblay provide evi­dence for this possibility.2) Theoretically, the grafted kidney's glomerular basementmembrane (GBM) may induce the recipient to form anti­bodies against the GBM of the grafted kidney. There is somepreliminary evidence to suggest this mechanism as a possi­bility in the case of transplants between non-identical twins.Future work, according to Dr. Steblay, should involve studyof the frequency of autoantibody disease in humans and theconditions under which the autoantibodies are formed. Somemeans might then be found to prevent the formation of theautoantibodies or decrease their activity if they are alreadypresent.Dr. Steblay has conducted hundreds of experiments to estab­lish the mechanism and existence of autoantibody involve­ment in glomerulonephritis during the past 10 years.The Next StepThere are just a few ways in which University of Chicagoscientists are groping with the problem of trying to controlthe body's immune response. The response problem is the same regardless of whether weare dealing with a small skin graft, a bone or a human heart.The body has developed this natural protection and man mustovercome it if he is to make some of the most significantsurgical techniques of history clinically meaningful.Dr. Raymond W. Steblay, '52, has discovered that certain autoantibodiescan induce successfully transplanted kidneys to develop the recipient'soriginal disease. Here he injects sheep with human glomeri tissue and achemical compound to stimulate immune response.13Residents Trained in 'New Psychiatry'One man carefully adjusts an electron microscope and beginsto scan a muscle sample for signs of an elusive enzyme.Another man adjusts a final electrode on the chest of a volun­teer and prepares for a long night monitoring his sleep. Awoman hands a tablet to a known narcotics addict who swal­lows it quickly, nods, and walks away. All three people areengaged in the science of psychiatry which is increasinglydependent on the basic biological and behavioral sciences.In the Division of the Biological Sciences and The PritzkerSchool of Medicine, an intensive three-year program has beenmolded to train physicians in this new psychiatry, in whichgenetics and neurophysiology are often as important as psy­choanalysis.Under the direction of Dr. Daniel X. Freedman, Professorand Chairman of the Department of Psychiatry, eight first­year residents have just begun this graduate training program.It will carry them through research, teaching, and practiceranging from the application of psychoanalysis, conditioningand learning theories, to drug abuse studies. The residentswill be brought into close working contact with most of the48 full-time faculty members of the department.The foundation for the training program rests on Dr.Freedman's belief that "the specialty of psychiatry, an appliedmedical science, must and will increasingly rest on the foun­dation of basic biological and behavioral sciences. The be­havioral sciences include psychology, sociology, anthropology,and, last but not least, the biologically-oriented behavioralscience of psychoanalysis."The bridge to biology is increasingly being built by theneuro-behavioral sciences in their study of the genetics andevolution of normal and abnormal behavior, as well as of. physiological and chemical activities of the body's neural sys­tem and their relation to behavior."In the program, the residents rotate through Clinical Servicesin full-time blocks where there are at least two full-time seniorfaculty members. Directing the Clinical Services is Dr. Jar1Dyrud, Associate Professor, (who until recently was withChestnut Lodge and the Institute of Behavioral Research,All patients in the service are in the care of the residents toallow training in individual psychotherapy with and withoutsupervision. Residents carry increasing responsibility so thatby the end of training they are fully qualified to practice inde­pendently. This psychotherapy experience continues through­out the three years of training. In the first year, the resident spends six months working withthe 25-bed inpatient service of The University of ChicagoHospitals. Major treatment emphasis is on individual andgroup therapy, family involvement, and milieu therapy withexperience in pharmacotherapy.For three months, the resident works in the ConsultationService of the University's 700-bed hospital complex, pro­viding liaison and consultation for specialists ranging fromgastroenterologists to plastic surgeons.Three months are then spent in the Student Mental HealthService, where their patients range from adolescents to oldergraduate students, with an emphasis on brief psychotherapy.In the second year, the residents begin with six months inthe Outpatient Service, designing total therapy and workingwith adults who experience personal or situational crises.They also participate in weekly clinic sessions for chronicallyill patients and become involved in experiences with com­m unity psychiatry.Allan Rechtschaffen, Professor of Psychiatry and Psychology, directs theSleep Laboratory, where researchers study the sleep and dream patternsof subjects under various clinical situations.14For the next three months, the resident serves in the ChildPsychiatry Service, which includes special seminars in normalgrowth and development and the opportunity to observe thepsychopathology of children. In addition, the resident obtainsexperience with inpatients at the University's OrthogenicSchool, a residential treatment center for severely disturbedchildren under the direction of Dr. Bruno Bettelheim, Pro­fessor of Psychiatry and Psychology, the Stella M. RowleyProfessor of Education and Director of the Sonia ShankmanOrthogenic School.The following three months include community mentalhealth experience, clinical experience in neuropsychiatricthinking, and experience' in behavior modification of thechronically hospitalized m�ntally ill.The entire third year is spent following a particular area ofinterest in one of the department's special programs, includ­ing:Child Psychiatry: Dr. John F. Kenward, '44, Associate Pro­fessor of Pediatrics and Psychiatry, directs a special trainingprogram in child psychiatry for third and fourth year residentsleading to qualification for the American Board of Child Psy­chiatry. Research specialists in infant and child developmentand in training procedures for special disabilities have joinedthis unit.Drug Abuse Program: Dr. Jerome Jaffe, Assistant Professor ofPsychiatry and a pharmacologist who has taught at Yeshivaand Rockefeller Universities, and studied treatment of nar­cotics addiction, has initiated a program in drug abuse whichreaches from the laboratory to the community. Researchopportunities in this program range from studies of the basicactions of amphetamines and hallucinogens in animals tolaboratory work on toxicology and drug detection, and toclinical studies on the use of methodone and narcotic antago­nists in the rehabilitation of narcotics users. This programincludes a IO-bed inpatient unit as an adjunct facility to theInpatient Service.Woodlawn Mental Health Center: An agency of the ChicagoBoard of Health, the center is directed by Dr. Sheppard G.Kellam and Dr. Sheldon K. Schiff, ' 56, Associate Professorsof Psychiatry, in cooperation with the Woodlawn Commu­nity. It introduces a unique research and treatment programthat brings a new approach to community mental healththrough emphasis on community action and school psychia­try. Residents have the opportunity to see how programs de- pending on authentic community sanction evolve and howresearch in the prevalence and epidemiology of disorders canproceed in a service context. One thousand school childreneach week in the first, second, and third grades are assessedby the psychiatric team in the classroom where group therapy,including parents and teachers, is also employed.The Biochemistry of Acute Psychoses: This program is underthe direction of Dr. Herbert Meltzer, Assistant Professor ofPsychiatry, who recently arrived from the National Instituteof Mental Health. It is carried on in a 15-bed research uniton a University of Chicago floor at the Illinois State Psychi­atric Institute, a facility near the University. Acutely psy�chotic patients are studied behaviorally and with measures ofserum enzymes, which Dr. Meltzer has recently discoveredto be markedly elevated in these conditions.Sleep and Dream Research: This multi-faceted program hasgrown from the original pioneer work by Nathaniel Kleitman,now Professor Emeritus of Physiology at the University. TheDepartment's sleep laboratory is under the direction of AllanRechtschaffen, Professor of Psychology and Psychiatry. Hisprimary interest is in the psychophysiological investigationof sleep in man and animals, with particular reference tothe physiology and biochemistry of the central nervous sys�tern. A second area of investigation under the direction ofDr. Gerald W. Vogel, '54, Research Associate in Psychiatry,is primarily concerned with alterations of the sleep patternespecially in schizophrenia and depression. In addition, Dr.Vogel studies relations between drugs which depress or ele­vate dream time and the clinical course of remission in thesesyndromes. A third area of investigation is the use of thepsychoanalytic method of transference analysis to study therelations among all the dreams of a night in patients whoare simultaneously in regular psychoanalytic treatment. Thisis under the general direction of Dr. William C. Offenkrantz,Associate Professor of Psychiatry.Neurochemical and Psychopharmacological Programs, underthe general direction of Dr. Daniel X. Freedman, focus onstudies of psychotomimetic drugs-drugs which produce simu­lated psychotic states-and their effects on brain· chemistry,perception and behavior. The behavioral laboratory is underthe direction of James B. Appel, Associate Professor of Psy­chiatry, and is equipped for various techniques, includingconditioning, and intra-cerebral electronic recording and stim­ulation.15Dr. Herbert Meltzer measures serum enzymes taken from patients at theIllinois State Psychiatric Institute, where he directs the Biochemistry ofAcute Psychoses program for the University.Richard A. Lovell, Instructor in Psychiatry, IS in charge ofthe Neurochemistry Laboratory where the metabolism of psy­choactive drugs and a variety of brain amines are studied.Lewis S. Seiden, Assistant Professor in Pharmacology andPsychiatry, directs another laboratory in the Department ofPharmacology, in which correlations of behavior and brainamines are studied with a variety of techniques.The Behavioral Analysis and Programmed Learning Labora­tory studies experimentally 'induced pathological behavior as well as remedial training techniques in animals. Results ofthese studies are applied in human educational, social, andclinical situations. The laboratory develops advanced tech­niques in programmed learning and carries on studies of per­ception. This program is under the direction of Israel Col­diamond, Professor of Psychology and Psychiatry, recentlyarrived from the Institute of Behavioral Research and theJohns Hopkins University.Aging and Geriatrics: A range of studies are focusing on thecapacities and impairments associated with aging. Morton A.Liebermann, Associate Professor of Psychiatry and the Com­mittee on Human Development, has been studying predic­tors of and adaptive response to impending death, and con­tinues his long-term studies of group processes. Robert Kahn,Associate Professor of Psychiatry and the Committee onHuman Development, is studying the relationship of com­munity processes of geriatric patient treatment. He is alsocontinuing long-term studies of adaptive responses in acuteand chronic brain syndromes.Dr. C. Knight Aldrich, Professor of Psychiatry, directs a pro­gram in which he hosts the Inter-University Forum for Edu­cators in Community Psychiatry, a two-week biannual semi­nar meeting in Chicago, attended by 15 visiting professorsand featuring a number of national experts.Philip Holzman, Professor of Psychiatry and Psychology, isstarting a program of prospective studies of perceptual andfeedback factors involved in schizophrenia. He is interestedin finding and identifying those populations which may havea high risk of developing this disorder. He is also continuingexperimental work in psychoanalytic studies of self-confron­tation.Dr. Eberhard Uhlenhuth, Associate Professor of Psychiatry,is responsible for the Outpatient Clinic and a range of re­search projects involving the characteristics of outpatientsand their response to a variety of treatment programs.The residency program is approved by the American MedicalAssociation and the American Board of Psychiatry and Neu­rology for three years of training and has been approved bythe United States Public Health Service for General Prac­titioner Fellowships. The child psychiatry program is ap­proved for the two years required by the American Board ofChild Psychiatry.16News BriefsAEC Renews ContractThe U.S. Atomic Energy Commission(AEC) has renewed its contract with TheUniversity of Chicago for operation of theArgonne Cancer Research Hospital for fiveyears at an estimated cost of $21,000,000.The University has had a contract with theCommission since 1950, when the presentfacility was built.The Hospital, part of the University's med­ical complex, is a research institution de­voted to study of radiation effects and useof radioactive materials in research. All re­search in the Hospital is unclassified andinvolves the use of nuclear energy for can­cer radiation treatment.Entire cost of the Hospital's operation issupported by the AEC. The Universityoperates the Hospital, and staff scientistshold appointments in the University's Di­vision of the Biological Sciences and ThePritzker School of Medicine.New Mothers' Aid PledgeMothers' Aid, a voluntary service organ­ization, has pledged $750,000 toward con­struction of an addition to Chicago Lying­in Hospital's Mothers' Aid Research Pa­vilion.The initial contribution was presented re­cently in behalf of the more than 1,500Mothers' Aid members.According to Dr. Frederick P. Zuspan, theJoseph Bolivar De Lee Professor and Chair­man of the Department of Obstetrics andGynecology, the addition will providespace for investigation in the field of re­production and will include a Mothers' AidPerinatal Study Unit.Approximately 10 years ago, Mothers' Aidpledged and raised $600,000 to remodela wing of Chicago Lying-in Hospital. Thearea, now known as the Mothers' Aid Re­search Pavilion, houses the basic researchlaboratories of the Department of Ob­stetrics and Gynecology.Chromosome Damage Research BeginsA project is being established at The Uni­versity of Chicago to discover if there is arelationship between chromosome damageand drug intake. The research involving the establishmentof an experimental system in animals willbe supported by a $68,549 two-year grantby the Pharmaceutical Manufacturers As­sociation Foundation, Inc., Washington,D.C.Research will be conducted by Anthony P.Amarose, Ph.D., Assistant Professor, andDr. James L. Burks, Assistant Professor, inthe Department of Obstetrics and Gyne­cology.The project will be carried out in the re­search facilities of the Chicago Lying-inHospital of the University.Protein Study FundedA grant of $232,356 has been awarded toThe University of Chicago by the JohnA. Hartford Foundation, Inc., of NewYork City to study the regulation of pro­�ein synthesis in cells.The grant was announced jointly by RalphW. Burger, President of the HartfordFoundation, and Dean Jacobson. A totalof $747,947 has now been granted by theFoundation for the research project sinceJanuary, 1963.The funds, under the direction of Dr. IraG. Wool, '53, Professor' of Physiology andBiochemistry, will be used over a three-yearperiod to continue research on a series offundamental problems including the mech­anisms by which some hormones influencegrowth.The project to date has resulted in newfindings related to biological regulation ofprotein synthesis, the action of chemicalswhich are used in treating cancer, and theeffect of insulin on the metabolism oftissue.$900,000 Given for Brain ResearchInstitute ConstructionRecent gifts of $900,000 toward the con­struction of a Brain Research Institute atThe University of Chicago have been an­nounced by Dean Leon O. Jacobson.Of this amount, $500,000 has beenpledged by Mr. and Mrs. William E. Fay,Jr., through the Brain Research Founda­tion, under whose sponsorship the BrainResearch Institute is being built. An anon­ymous friend of the University and theFoundation has pledged $400,000. The University and the Foundation havenow jointly raised over $2,000,000 of the$3,500,000 in private funds needed towardthe projected cost of $5,800,000. It is an­ticipated that the balance will be availablein matching grants from the federal gov­ernment.The Brain Research Institute will be aseven-story structure, integrated with theexisting hospital. It will be under the di­rection of Dr. John F. Mullan, Professorof Neurosurgery.Merck Grant Supports School PlansThe Merck Company Foundation hasgranted the University $50,000 for the de­velopment of comprehensive plans for anew medical Teaching Building. Construc­tion of this building will be a key to theproposed increase of incoming· medicalschool classes from 79 to 100.The five-story Teaching Building, now inthe planning stage, will contain labora­tories and classroom facilities, an audi­torium, and seminar rooms for instructionof medical and graduate students.Representing the Merck Company Foundation,Maurice R. Hillernan, Ph.D. '44, presents DeanLeon O. Jacobson (r.) with one of two $25,000 checks.17In Memoriam: Jessie Burns Maclean1905-1968Mrs. Maclean was .with the Universityfor more than 30 years. She served assecretary in the Department of Biochem­istry from 1929-1943, and as ExecutiveSecretary to the Medical Alumni Associa­tion from 1952 to 1967. She died Decem­ber 7, and memorial services for her wereheld on December 17 at the University'sJoseph Bond Chapel. The following is atribute to her from Dr. Sidney Shulman,'46:We have come together here to honor thememory of Mrs. Norman Maclean. Weinterrupt the action of our lives, as herfamily and as her friends-and as a medi­cal school, in order to do this, and to ex­press outwardly our awareness of whatshe meant to us.J essie Maclean worked for a total of morethan 30 years in this University. In 1950,she was invited by one of her husband'sformer students, who is now Dean ofHarvard Medical School, to come to workfor the Medical Alumni Association. Inthat year, Dr. Robert Ebert was Vice­President and Dr. John Van Prohaska wasPresident of the Alumni Association, andthey were looking for a secretary to do thetyping and the filing in the office. Jessieaccepted the invitation, and stayed on for17 years as Executive Secretary of theMedical Alumni Association until her re­tirement in 1967. She served under 17presidents and presided over the affairsof the Alumni Association during a periodof enormous expansion of its activities.Because Jessie was there, the office of theAlumni Association came to be dependedupon for organizing a whole series offunctions that are not naturally a part ofthe responsibility of that office-functionslike the Senior Scientific Meetings wheresenior medical students present their re­search, the freshman orientation pro­grams, the medical education programs forpractitioners, and the medical career con­ferences for senior high school students.All of these were in addition to the regularresponsibilities of the office-the publica­tion of the Alumni Bulletin, the holdingof the annual Alumni' Dinner for thegraduating class, and the organization ofa host of social and fund raising functionsat a distance in all parts of the country. Jessie had an incredible knowledge of thewhereabouts and the activities of our medi­cal alumni, and there were more than5,000 of them at the time she retired.In recognition of all of this service to ourschool, Jessie Maclean was given the GoldKey Award for Distinguished Service bythe Alumni Association in 1966. This wasthe first and only time this award waspresented to someone who was not agraduate of the school, and who was not aphysician or a biologist.But there was more to Jessie's contributionto the school than all of this work. Therewere things beyond the efficiency, andeven beyond the style, the grace and thetact which she brought to her work. Forme, there is no way to describe thesethings completely.Jessie knew what was to be said. She saidless than she knew, but she said enough,and she said it with humor, with literaryallusions, and with simplicity.Jessie's office was next to the medicalstudents' lounge and locker room, andshe came to be a sort of house mother tothem. Yet, she was unaware of it. She gaveno display of prideful awareness- notMrs. Jessie Burns Mac­lean, upon receiving theGold Key of the-MedicalAlumni Association in1966. in words, and not in the look of her face-no self-satisfied awareness that what shewas doing was noble. She was not play­acting. It was part of her existence. Andso she was not obtrusive and she was notmeddlesome, and she was not oppressivelygood-hearted.We live in a chancy-some would sayaninimical-universe. Most of us mustconceal this, or live running-scared. Weconceal it by living by fables. Some of thefables are institutionalized and some ofthe fables are personal. But there are afew people in the world who have nofables and no fears. These are people whoaffect us in a way we cannot explain-notuntil their own lives are stripped of theprotection of our flimsy biological adap­tations and they come to face the nakedharshness of death. It is then we see whatmust be behind the special character ofsuch people. We see that they are notterrified, not consumed by bitterness-noteven disappointed, because they did notlive by fables. They lived easily with un­retouched knowledge of the world and oflife and death., Jessie Maclean was that kind of person.18News of Alumni'35. Arthur H. Rosenblumis president ofthe Chicago Society of Allergy and chair­man of the penicillin study group of theAmerican Academy of Allergy.'37. Clayton G. Loosli, professor of medi­cine and pathology at the University ofSouthern California School of Medicine,and medical director for the HastingsFoundation, has been named president­elect of the Tuberculosis and RespiratoryDisease Association of Los Angeles Coun-ty., 38. Robert L. Schmitz, clinical professorof surgery and coordinator of cancer teach­ing at the Stritch School of Medicine,Chicago, has been elected president ofthe American' Cancer Society, Illinois Di­vision. In addition, Dr. Schmitz is pres­ident of Mercy Hospital medical andscien tific staff., 41. Frederick J. Stare is au thor of anationally syndicated column, "Food andYour Health." He is chairman of the de­partment of nutrition at Harvard Univer­sity's School of Public Health.'45. Peter V. Moulder has left The Uni­versity of Chicago to become head of thedepartment of surgery at Pennsylvania Hos­pital in Philadelphia.'47. Max Griffin of Akron, Ohio andThomas \ViIson, '61, of Fort Worth,Texas were recent visitors to the medicalschool while in town for the pediatricsmeeting.'51. Ethel Bonn has been appointed di­rector of the Fort Logan Mental HealthCenter in Denver. Dr. Bonn, a psychiatrist,has been at Fort Logan since 1962, firstas assistant director for clinical servicesand then as acting director.William M. Smith has been appointeddirector of the U.S. Public Health ServiceHospital in San Francisco. Dr. Smithformerly served as chief of medicine atthe hospital.'52. Raymond N. Kjellberg has been pro­moted to assistant clinical professor ofsurgery at Harvard Medical School. Healso is assistant neurosurgeon at the Mas­sachusetts General Hospital. Joseph S. Skom, assistant professor ofmedicine at Northwestern University Med­ical School, is chairman of the IllinoisState Medical Society's Committee onNarcotics and Hazardous Substances.'54. Henry C. Maguire has joined thestaff of Hahnemann Medical College,Philadel phia.'55. Larry Nathanson is now assistant pro­fessor of medicine at Tufts UniversitySchool of Medicine, Boston, where hisprincipal interest is in clinical oncologyand cancer research. He writes that othersfrom his class in Boston are John David(Robert Breck Brigham Hospital), MartinFlax (Mass. General Hospital), FloydGilles (Children's Hospital), Richard Sieg­ler (New England Deaconess Hospital),and David Singer (Mt. Auburn Hospital).Myron E. Tracht, director of laboratoriesat Holy Name Hospital, Teaneck, NewJersey, and assistant professor of pathologyat Columbia University College of Physic­ians and Surgeons, has received a grantfrom the Bergen County Heart Associa­tion to study the relationship of cholesterolto the liver. Dr. Tracht has been con­ducting research on' the effects of injuryto the liver.'57. Myron R. Karon has been appointedassociate professor of pediatrics at theUniversity of Southern California Schoolof Medicine, Los Angeles. He is currentlyinvestigating the molecular pharmacologyof the cell cycle and children's cancer studygroup A, under cancer research grants.'58. Attie Yvonne Russel1 has been ap­pointed assistant dean and associate pro­fessor of pediatrics at the University ofCincinna ti Col1ege of Medicine. She willwork in matters of public policy, such asprograms of community health and alliedhealth personnel. Dr. Russell was directorof Maternal, Child, and Crippled Chil­dren's Services for the Delaware StateBoard of Health., 59. Morton H. Goldstein practices plasticand reconstructive surgery in New Bruns­wick, New Jersey.David M. Hirsch, Jr., has moved to Bir­mingham, Michigan where he is in generaland thoracic surgery, as well as being as­sistant professor of surgery at WayneState University School of Medicine and at fhe V.A. Hospital at Allen Park. Heand his wife are the parents of three sons.Seymour Rosen has been promoted to as­sociate in pathology at Harvard MedicalSchool, serving at the Peter Bent BrighamHospital.'60. Donald Comiter completed two yearsin the Navy as chief of urology at the U.S.Naval Hospital, Charleston and as uro­logic consultant at the USAF Hospital,Myrtle Beach, So. Carolina. Now in privatepractice in Pompano Beach, Florida, hisfamily includes two girls and a boy.'61. Owen Rennert has left The Universityof Chicago Department of Pediatrics tojoin the staff of the University of Florida,Gainesville.'63. John A. Dawley is fulfilling his mili­tary obligation as Capt. MC, USA, chiefresident, neurosurgery, Tripler GeneralHospital, APO San Francisco.William B. Svoboda is a resident in pe­diatric neurology in the Mayo GraduateSchool of Medicine, University of Min­nesota, Rochester.'64. Bernard J. Ransi] has been promotedto associate in medicine at the HarvardMedical School. He also is assistant phy­sician at the Thorndike Memorial Labo­ratory and clinical associate in medicineon the Second and Fourth (Harvard)Medical Services of the Boston City Hos­pital.Carrie K. Schopf is on the staff of internalmedicine at St. Luke's Hospital, LehighValley, Pennsylvania.'65. William Pilchard completed his mi­litary service at the USPHS, Indian Hos­pital in Phoenix and is now a resident inophthalmology at the Eye & Ear Hospital,University of Pittsburgh.19Rush Alumni'13. Edwin M. Mmer has been asked bvthe Presbyterian-St. Luke's Hospital Boardto establish a historical museum at thehospital which will include the early his­tory of the hospitals, subsequent affiliation,and the early association with Rush Medi­cal College. If any alumnus has material ofhistorical importance, he may write Dr.Miller at the hospital.'15. Leon Unger, associate professor atNorthwestern University School of Medi­cine, and senior attending physician atChicago Wesley Memorial Hospital, wascited by The City of Hope, National Med­ical Center, for his leadership in the fieldof allergy. Citations were presented to fourmedical men at the Center's Eleventh An­nual Salute to Medical Research held inChicago on N ovem ber 23.'21. Lester R. Dragstedt, the Thomas D.J ones Professor Emeritus in the Depart­ment of Surgery, received the first distin­guished alumnus award of the Rush Med­ical College Alumni Association for hisoutstanding contribution to the field ofsurgery. The presentation was made at theAssociation's annual meeting in San Fran­cisco.'22. Floyd E. Keir, formerly chief of urol­ogy at Englewood Hospital, New Jersey,retired from practice this spring to live inPhoenix, Arizona, where he is now on thePublic Health Nursing Service Staff.'23. James L. McCartney is organizing theninth educational cruise for TIPS (Trans­International Psychosomatic Seminars) tothe South Pacific. Scientific discussions willbe held for 63 days aboard the 55 PresidentCleveland, sailing from San Francisco onDecember 20, 1969. Those interestedshould contact Dr. McCartney, Box 1309,Westhampton Beach, New York 11978. '37. Jacob Sander Aronoff writes that hehas specialized in facial plastic surgery forthe past ten years. Each fall for the pastfive years he has spent eight to ten weeksdemonstrating the American techniques inrhinoplasty throughout the world. Dr.Aronoff received the Diplomate of theAmerican Board of Otolaryngology in 1943.'39. Robert F. Rushmer, head of the di­vision of bioengineering at the Universityof Washington School of Medicine, wasnamed president of the new BiomedicalEngineering Society of America.'41. Paul P. Pickering is vice president ofthe American Society of Plastic and Re­constructive Surgery. Dr. Pickering lives inSan Diego.'42. Frank W. Johnson continues to prac­tice ophthalmology with a partner in Kla­math Falls, Oregon, where he moved in1949. He writes, "enjoy the mountain andforest scenery and am an ardent 'barber­shopper (part singing, a cappella)'." Mar­ried to the former Doris Argile, '43, theoldest of their three sons is a senior at theUniversity of Oregon.Family RecordIn the Rush alumni class notes of our lastissue we mentioned that Tolbert F. Hill,Rush '96, of Athens, Illinois, and his fourbrothers all graduated from Rush. (In ad­dition, his father, son, grandson, nephewand great-nephew are all physicians) .We have now heard from another Rushalumnus. Samuel W. Forney, '08, of Boise,Idaho, writes that his grandfather gradu­ated from Rush in 1857, followed by fourgenerations of doctors, eight of whomgraduated from Rush. In addition to Sam­uel, Richard A. Forney, Rush '39, andWilliam D. Forney, U. of C. '43, are prac­ticing in Boise.Can anyone beat this record? News of FormerFaculty, Internsand Residentslain E. Boyd (,64-'68) completed his resi­dency in Obstetrics and Gynecology andis now Registrar in Obstetrics and Gyne­cology at the University College Hospitalin London, England.Arnold L. Case ('66-'68) left the staff toaccept a full-time position in the depart­ment of obstetrics and gynecology at theHartford General Hospital, Hartford, Con­necticut.Andre O. Devos ('65-'68) completed his. residency in Obstetrics and Gynecologyand is in private practice in Brugge, Bel­gium.Marvin Forland (tac. '58-'68) left the De­partment of Medicine to join the staff atthe University of Texas Medical School inSan Antonio.Dorothy Hamre (tac. '52-'68) formerly As­sistant Professor of Medicine, left the staffand is living in Ouray, Colorado, with herhusband.Sophia Kleegman· ('27-'28) clinical pro·fessor of obstetrics and gynecology and di­rector of the infertility clinic at BellevueHospital, New York, was one of five NewYork University graduates awarded theAlumni Meritorious Service Medal for1968 for outstanding service to the Uni­versity.Ardis R. Lavender (tac. '53-'68) left theDepartment of Medicine to become chiefof Renal Section, Veteran's AdministrationHospital, Hines, Illinois.Denes Martonffy ('63-'68) completed hisresidency in neurosurgery and joined thestaff of Veteran's Administration Hospital,Hines, Illinois.Ilza Veith (lac. '49-'63), professor andvice-chairman of the department of theHistory of Health Sciences, and professorin the department of psychiatry, Univer­sity of California San Francisco MedicalCenter, was elected Honorary Fellow ofthe American Psychiatric Association, andFellow of the Royal Society of Medicine ofEngland.A. Earl Walker (fac. '31-'47) professor ofneurosurgery at Johns Hopkins Hospital,delivered the "Second Percival Bailey Ora­tion in Neurosurgery" at the Central Neu­rosurgical Society Meeting, held in Chi­cago in Septem bet.20FacultyPaul E. Carson, associate professor of med­icine, is in London, England, collaboratingwith Professor Harry Harris of the GaltonLaboratory, University College.Robert E. Cleary has been appointed as­sistant professor in the department of ob­stetrics and gynecology. A paper by Dr.Cleary, a Junior Fellow of the- AmericanCollege of Obstetrics and Gynecology, re­cently was selected as the 1968 MemorialFoundation Award Essay of the PacificCoast Obstetrical and Gynecological So­ciety. His research centers on the role ofthe fetus in maternal urinary estriol ex­cretion.Albert Dorfman, '44, the Richard T. CraneProfessor of pediatrics and chairman ofthe department, received 'a GuggenheimMemorial Foundation Fellowship for hisstudies of the differentiation of connectivetissue cells affected in cases of rheumaticfever and related rheumatic and arthriticdiseases. Dr. Dorfman is on sabbaticalthrough June working in the laboratory ofDr. Leo Sachs, Department of Genetics,the Weizmann Institute of Science, Reho­voth, Israel.Alfred P. Fishman, professor of medicinehas been appointed to the National Ad­visory Heart Counci1.Uwe E. Freese, associate professor in thedepartment of obstetrics and gynecology,was invited to speak at the InternationalSymposium on the Placenta, in Milan,Italy, and at the Annual Meeting of theGerman Gynecological Society. While inGermany, he lectured at several universi­ties. Dr. Freese and Dr. Gebhard Schu­macher, associate professor in the same de­partment, were elected to membership inthe Society for Gynecological Investiga­tion.Zdenek Hruban, '56, associate professor ofpathology, recently received an achievementaward from the Travelers Aid Society ofMetropolitan Chicago. Born in Prerov,Czechoslovakia, Dr. Hruban is known forhis devotion to Czech and Slovak causesin America. He was one of five Chicagocitizens of foreign birth to receive thehonor, conferred at the 10th annual awardsdinner of the Society'S Immigrants' ServiceLeague. Charles B. Huggins, the William B. OgdenDistinguished Service Professor of Surgeryand Director of the Ben May Laboratoryfor Cancer Research, recently received thehonorary degree of Doctor of Science fromthe University of Michigan.Leon O. Jacobson, '39, Dean of the Di­vision, has been named to a four-year termon the National Advisory Cancer Council.Richard L. Landau, professor of medicine,was local chairman for the Endocrine So­ciety's 20th Annual Postgraduate Assem­bly on Endocrinology and Metabolismheld on, the campus. Other faculty par­ticipating were Elwood Jensen, professorof physiology, Leslie J. DeGroot, r,rofessorof medicine, and Ira G. Wool, 53, pro­fessor of physiology and biochemistry.Ann Lawrence, assistant professor in medi­cine, in addition to her teaching and re­search fellowship award from the Ameri­can College of Physicians, has been nameda Markle Scholar for 1968-69. Recentlyappointed Liaison Officer between theschool of medicine and the Illinois Re­gional Medical Programs, she is Chairmanof the Regional Medical Program Commit­tee of the medical school.Albert B. Lorincz, '46, professor of obstet­rics and gynecology, has' been awarded agrant from the Damon Runyon MemorialFund for Cancer Research to test theeffect of a restricted nutritional diet oncancer cells. By limiting the patient's in­take of phenylalanine, he has found indi­cations of significant tumor "starvation"with few other adverse effects.Gregory Matz, instructor in otolaryngol­ogy, is fulfilling his military service atBrooks Air Force Base in San Antonio,Texas, where he is teaching medicine atthe School of Aerospace.Robert D. Moseley, Jr., professor andchairman of radiology and director of radi­ation protection service, has been appoint­ed director of the biological sciences com­puter facilities and associate director of theUniversity computation center.Raymond D. A. Peterson, associate pro­fessor of pediatrics, discussed organ rejec­tion and the establishment of tissue typinglaboratories at a recent meeting in Chi­cago co-sponsored by the University and the American College of Cardiology. Themeeting was directed by C. Frederick Kit­tle, '45.Henry Rappaport, professor of pathology,is one of five university faculty membersawarded a Fulbright-Hays grant for 1968-69 by the U.S. Department of State. Dr.Rappaport is lecturing in pathology at theUniversity of Chile in Santiago.Christen C. Rattenborg has been nameda member of the Order of Ruben Dario,with the degree of "Caballero," the high­est honor conferred by the, Republic ofNicaragua. Dr. Rattenborg, associate pro�fessor in surgery, was honored for pro�viding assistance during the Nicaraguanpolio epidemic of August, 1967.Leon Resnekov, associate professor of med­icine, is project director of a ,$550,000grant from the National Heart Institute toestablish a two-bed heart attack researchunit in the Cardiology Center. Assistinghim will be Harry A. Fozzard, associateprofessor, Hans H. Hecht, Blum-Riese pro­fessor of medicine and head of cardiology,and physicians from other departments.Robert W. Wissler, '49, professor andchairman, Vincent Chao Yang Kao, '63,resident, and Katti Dzoga, research asso­ciate, all in the' department of pathology,reported at the 22nd Annual Meeting ofthe American Heart Association in Florida,new evidence that excess fat in the bloodmay well influence the increase of smoothmuscle cells of the arteries and contributeto the creation of atherosclerosis. Thestudy implies that the smooth muscle layerof the large and medium arteries is thefocal point of atherosclerotic development.With Draga Vesselinovitch, research asso­ciate in pathology, Dr. Wissler reportedat the same meeting that a combination ofdrug therapy and increased oxygen reversedatherosclerosis in male rabbits tested.21Associa tion Acti vi tiesSurgeryFifty alumni and wives representing grad­uates of Rush Medical College, The Uni­versity of Chicago, and the surgery res­idency program, gathered for dinner atthe first surgery reunion, held during theAmerican College of Surgeons meeting inAtlantic City in October.T. Howard Clarke (Res. '38-'41), pro­fessor of surgery at Northwestern Uni­versity Medical School, was chairman ofthe reunion, planned in response to anenthusiastic endorsement by the alumni.Next year's meeting and reunion will bein October in San Francisco. Mark yourcalendar now.Otolaryngology, Orthopedic SurgeryTwo other alumni gatherings were heldrecently. In October during the occasionof the American Academy of Ophthalmol­ogy and Otolaryngology meeting, thosewho trained in otolaryngology met at theannual John R. Lindsay Alumni Associa­tion reception. Ralph Naunton, Chairmanof Otolaryngology and secretary of thegroup, arranged the party.In January, the orthopedic surgery re­sidents planned a get-together under thechairmanship of Crawford J. Campbell,(Res. '46-'48) during the American Acad­emy of Orthopedic Surgeons meeting inNew York City.RadiologyAt the time of the annual meeting of theRadiological Society of North America, 95radiology graduates, residents and wivesgathered at the Center for ContinuingEducation on campus for a reception anddinner.I Among the honored guests were Paul C.Hodges and Mrs. Janet Reid KelloggHodges and Mrs. Nels M. Strandjord.Robert D. Mosley, Jr., Chairman of Ra­diology, was host for the occasion. A me­morial tribute to Dr. Strandjord was givenby the Rev. Carl Nighswonger, Chaplainof the Clinics, with closing remarks byDr. Hodges. Guests at the recent surgery reunion included (1. to r.) Louis F. Plzak Sr., Rush '28, his sonLouis F. Plzak, Jr., '58, Edward Woodward, '42, and Harwell Wilson, Res. '32-'39.At the radiology reunion, honored guests (1. to r.) Mrs. Nels M. Strandjord, wife of the lateDr. Strandjord, and Dr. and Mrs. Paul C. Hodges, chat with Dr. Robert Mosely, Jr., Chairmanof the Department.22Deaths'02. Nelson Edgar, Los Angeles, Calif.,November, 1967, age 91.Daniel T. Quigley, Omaha, Nebraska,October, 1968, age 92.'03. George A. Darrner, Aurora, Ill.,June 12, 1968, age 94.'04. Mabel E. Elliott, Lake Park, Fla.,June 13, 1968, age 87.'06. Horace M. Francis, Salem, Oregon,1967, age 84.Alvin B. Snider, Blue Island, 111.,June 12, 1968, age 91.'07. George F. Bicknell, Gainesville, Fla.,August 7, 1968, age 86.'10. Robert O. Ritter, DeLand, Florida,May 28, 1968, age 84.'II. Clarence Emerson, Lincoln, Nebr.,June 23, 1968, age 82.Sydney Walker, Guadalajara, Mexico,August 3, 1968, age 84.'12. Robert B. Acker, South Bend, Indiana,July 8,1968, age 84.'16. William R. Jackson, Kansas City, Mo.,May 25, 1968, age 75.Elmer L. Mertz, Lake Helen, Fla.,November 19, 1968, age 83.'17. Roger M. Choisser, Washington, D.C.,December 19, 1967, age 76.'19. Martin C. Lindem, Salt Lake City,Utah,December 28, 1968, age 79.William A. Kristensen, Pasadena, Calif.,March 2, 1967, age 83.'20. Otto P. Diedrich, Fresno, California,August 5, 1968, age 73.Harry E. Kasten, Beloit, Wisconsin,September 28, 1968, age 80.'22. Ernest O. Larson, Chicago,November 9, 1968, age 71.'23. Thorald E. Davidson, Mason City, .Ia.,December 31, 1967, age 72.Edith T. Fisher, Crestline, California,October 3, 1968, age 79. Roy L. Grogan, Fort Worth, Texas,November 4, 1968, age 78.Robert H. Smuckler, Milwaukee, Wis.,November 12, 1968, age 71.'24. Nelson W. Barker, Rochester, Minn.,August 26, 1968, age 69.Ellis H. Edwards, White Plains, New York,October, 1968, age 76.Roland A. Jacobson, Arlington Heights, Ill.,September 28, 1968, age 72.Thure A. Norlander, Hot Springs, Ark.,August, 1968, age 73.'25. Rowe G. Baker, Tomahawk, Wis.,November, 1968, age 67.'27. Robert A. Crawford, Albuquerque,New Mexico,July 17, 1968, age 72.'28. Annette Howell, Napa, California,April 19, 1968, age 75.'29. Maj. Gen. William S. H. Chow,Taipei, Formosa,July, 1968.'30. Peter F. Coleman, Livonia, Michigan,July 8, 1968, age 67.Albert M. Wolf, Chicago,August 23, 1968, age 62.'31. Catherine I. Wickham, Thiells, N.Y.,October 11, 1968, age 69.'32. Ying Tak Chan, Washington, D.C.,December, 1968, age 62.Sidney Rosenberg, Chicago,September, 1968, age 64.'34. Cecil J. Metcalf, Bangor, Maine,August 7, 1967, age 60.'35. John W. Devereux, Honolulu, Hawaii,November 14, 1968, age 61.'37. Robert M. Davis, Denver, Colorado,July 5, 1968, age 55.'38. Gordon C. Pratt, East Lansing, Mich.,July 28, 1968, age 57.'39. M. Alex Krembs, Milwaukee, Wis.,November 19, 1968, age 58.'40. Laurence L. Palitz, Manhasset, N.Y.,September 19, 1968, age 56.'41. Sidney F. Hurwitz, Milwaukee, Wis.,August 24, 1968, age 51.'42. William T. Roberts, Buffalo, N.Y.,October 30, 1968, age 53. DeathsFormer Interns, Residents and FacultyJ. Mace Harkey, (Resident, Pediatrics '36-'39), Canton, Ohio,May 15, 1968, age 61.George Otis Whitecotton, (Supt. of Clin­ics, '39-'46), Oakland, California,December 16, 1968, age 70.Franklin C. McLean FundsTwo funds have been established in mem­ory of Franklin C. McLean, Rush '10, Pro­fessor Emeritus in the Department of Physi­ology, whose obituary appeared in our lastissue.One of Dr. McLean's special interests wasthe education of Negro students for careersin medicine. To further this cause, theFranklin McLean Medical Student Schol­arship Fund has been started to assist .Afro­American students at The University ofChicago.The second fund is the Franklin C. Me­Lean Research and Teaching Fund inPhysiology, established with an initial giftfrom one of Dr. McLean's former studentsand close friends.Any alumnus wishing to contribute tothese funds may do so through the MedicalAlumni Fund. -Dr. Franklin C. McLean23Nels M. Strandjord FundsTwo funds have been established to honorthe memory of Nels M. Strandjord, '46,Associate Professor of Radiology, whopassed away suddenly September 11 of apulmonary embolism.Dr. Strandjord had been a member of thedepartment since 1955, first as a residentand later as a faculty member; during theyears 1965-67 he was chairman of radiol­ogy at the University of Kansas.Dr. Nels M. StrandjordThe Nels M. Strandjord Medical StudentLoan Fund will bear his name in per­petuity and will be used to providemedical students with financial assistance,a cause he believed in keenly.The Nels M. Strandjord Memorial Awardin Radiology has been established by theresidents and students in the Departmentof Radiology and will be given annuallyto a senior medical student who has doneoutstanding work in this field.Dr. Strandjord will be remembered by hisstudents and colleagues as a dedicatedteacher. In recognition of this, he wasnamed by the students in the class of1960 as the first recipient of the James A.McClintock Award for outstanding medi­cal teaching at the University.His friends will remember him for hisservice to others. In 1960 he helped or­ganize the radiologic facilities at the Medi­cal School in Taiwan. In 1962, he spenta month in Algiers during the revolutionto tend to the needs of the people; in1967 he served as a volunteer in Vietnam.Those alumni who wish to rememberDr. Strandjord may contribute to eitherof these funds through the MedicalAlumni Fund. NEWS FOR MEDICINE ON THE MIDW A YHave you changed positions, moved, published, lectured, travelled, been appointedto office in a medical society, or been honored by a medical or civic organization?If so, let us know ... we'd appreciate it. Clip this coupon, or, if more convenient,use supplementary sheet.Name, Class of _Calendar of EventsWednesday, April 23: During the meetingof the American College of Physicians inChicago, a reception and reunion will beheld in the Conrad Hilton from 6 to 7P.M. Reception committee for this eventis: Walter L. Palmer, M.D., Rush '21,Pres., Am. College of Physicians, 1956,Master, 1961; Leon O. Jacobson, M.D.'39, Master, Am. College of Physicians,1968, Dean of the Division of BiologicalSciences and The Pritzker School of Medi­cine; Douglas N. Buchanan, M.D., Fac­ulty 1932-, Pres., Medical Alumni Assn.,Professor Emeritus of Pediatrics.Thursday, June 12: Medical Alumni Re­ception and Banquet, Pick-Congress Hotelin Chicago, Reception at 6 P.M. in theRendezvous Room, dinner at 7 P.M. inGreat Hall. This year marks the 40th an­niversary of the first graduating class fromthe south side campus. Douglas Buchanan,Pres. of the Med. Alumni Assn. and hiscommittee and officers are planning aninteresting evening. Further informationand reservations forms will be mailedshortly to all alumni.Week of July 13-17: American MedicalAssn., New York City. A reception isbeing planned with details to be mailedlater. Class Reunions:The following classes are planning reunion'If you have not received information, wrifto the chairman care of the Alumni Assn.1919 Rush: 50th anniversary observationand 1943 (Dec. Class), on June 12 at thlMedical Alumni Banquet. Chairman '43 .......James Schoenberger.1934: Andrew J. Brislen, chairman.1944: David Fox, chairman.1958: Reunion on Friday, April 25, at theQuadrangle Club, University Campus. Re­ception, 6 P.M., Dinner at 7 P.M. Geral�Herman, chairman.Career ConferenceThe Medical Alumni Association is againoffering a Biomedical Career Conferenceat the University for interested high schoolstudents. The all-day program will be heldSaturday, April 19 .Reminder:Members of the classes of '43, '58 and '66:Please send in your news item as soon a�possible for publication in your class newsletters.Info:Address, ___Mail your item to Medical Alumni Association, University of Chicago, 950 East59th St., Chicago, I11inois 60637.24Faculty CommentDr. Robert S. DanielsAssociate Professor ofPsychiatry & Associate Deanfor Community & Social MedicineThe Medical School and Its Relationship to the CommunityThis nation currently is confronted by a series of interlockingproblems which in composite form the syndrome of the urbanslum with its disadvantaged populations. Poor housing, over­crowded dwellings, inadequate economic opportunities, un­employment, educational disadvantages and high indices ofsocial, psychologic, medical, and legal disorders are symptomsof this syndrome.The medical school's participation in assessing and inter­vening in this disorder is a matter of controversy. Adding newactivities and programs to existent ones may at a minimumrequire the acquisition of new resources or the reallocation ofold resources. At a maximum it may require re-examinationof basic goals and purposes. Some would advocate the disrup­tion and destruction of 'current educational, research, andtraining.systems. At another extreme some express great satis­faction about the status quo and would change little.Typically, there are too few physicians in practice in theseareas. Those who are find overwhelming numbers of patientswith complex needs. There are relatively limited resourcesfor, health education, prevention, early intervention, conti­-nuity of care, and rehabilitation. Crisis medicine is frequentlynecessary. Patients arrive too late and too infrequently for" optimum care. New physicians are not attracted to theseareas and those in practice may become discouraged andleave. Community hospitals are also in difficulty. Outmodedphysical plants, overcrowding, limited aging staffs, and diffi-i culties in relating to changed communities often combine toplace the community hospital in a precarious position. Muchof the outpatient and most of the hospital care does notoccur in offices or institutions nearby but rather in large dis­tant facilities usually operating at the limits of their capaci­ties. Public financial support flows uncertainly and irregularlyso that many institutions are unsure of payment.What can a medical school do? It can encourage profession­als, clinics, hospitals and other resources to remain and worktogether. It can support the development of new resources.It can provide primary service relevant to its clinical, edu­cational and research needs. It can contribute experimentaland demonstration programs for target populations and it canassess and compare various systems already established.Three Divisional departments have already begun programsof significance. The Department of Obstetrics and Cynecol-74 Dr. Robert S. Danielsogy provides prenatal, delivery, and postnatal care for a groupof high risk, low income mothers living in neighborhoodsaround the University. In addition, they plan community­oriented counseling programs for family planning.The Department of Pediatrics has established the WoodlawnChild Health Center located on 63rd Street in the Woodlawncommunity. In a little more than a year of operation theyhave seen more than 5,000 different children at least once.This total represents almost 20 per cent of the total childrenin the area.The Department of Psychiatry has initiated two programs.The Woodlawn Mental Health Center, a Chicago Board ofHealth Clinic whose program was featured in the last issueof Medicine on the Midway, provides psychiatric services forthe Woodlawn area. Jointly, with the State of Illinois De­partment of Mental Health, The Department of Psychiatryalso has begun a drug abuse program which now serves manydrug addicts from Chicago and surrounding areas.Students of the medical school have engaged in many corn­munity related activities. For the past two summers the Stu­dent Health Organization, with large contributions from TheUniversity of Chicago medical students, has engaged in com­munity health matters in collaboration with local social andhealth agencies and community organizations by participatingin health use and need surveys, the formation of citizengroups to seek improved health services, and related activities.Health planning has also been an important faculty interest.At the neighborhood level a number of medical school facultyhave been active in advising the Woodlawn community onmeeting its health needs through their Model Cities pro�posal, At other planning levels medical school staff are par�ticipating with groups assessing the need for new outpatientand hospital facilities and programs on the South Side ofChicago with the goal of making this area self sufficient forits medical needs.Participation in the community exposes faculty to new pres�sures. The administration and faculty are often uncertainabout how to proceed and to be involved. However, studentsand faculty should have the opportunity to engage the medi­cal and social issues of our time for clinical service, training,and research. To ignore them would he to compromise thebasic functions of an educational institution-to transmit anddevelop past, current, and new knowledge.25MEDICINE ON THE MIDWAYTHE UNIVERSITY OF CHICAGO950 EAST 59TH STREETCHICAGO, ILLINOIS 60637•RETURN REQUESTED NON-PROFIT ORG.U.S. POSTAGEPAIDPERMIT NO. 9666CHICAGO, ILL._� � � �_� � 'H_'"