NOTES AND COMMENTThe seventy-fifth anniversary celebration of The University of Chicago has beenmarked by so much building expansion that it's difficult to keep track of it all. TheSearle Chemistry Building is well on its way to completion, the new geophysical sciences building has been started, the renovation of Cobb Hall as the new home for theCollege is slowly going forward, and construction will soon begin on the JosephRegenstein Library. In the Division of Biological Sciences, the Wyler Children'sHospital bas been dedicated, work on the Central Animal Quarters has begun, plansfor the new surgery wing are in progress, and proposals for a biological scienceslibrary are being studied.It would be impossible to list all the special events commemorating the anniversary. The more recent ones include the International Congress on Human Geneticsheld in September and the International Symposium on Host-Tumor Balancesponsored by Argonne Cancer Research Hospital in October. In that same month,the Humanities Division held a lively symposium on The Arts and The Public participated in by artists, critics, and writers from all over the country. The firstvolume of a history of the University, Harper's University, written by RichardStorr of the history department, has been published.An outsider, visualizing all the construction equipment cluttering up the campusand all the eminent speakers and guests arriving and departing, might get the ideathat there's not much regular work going on around here. But that is not the case.You attend a special lecture or ceremony if you have time and you dodge thebulldozers or walk around the barricades to get to your office, your class, yourclinic, your laboratory, or your job. Teachers still teach; students still attend classes.Work goes on pretty much as usual.It reminds us a little of Charles Huggins who last month quietly added a capstoneto the University's seventy-fifth anniversary by receiving the Nobel Prize in medicine. Over the years, Dr. Huggins has received the highest awards of many distinguished societies and institutions all over the world, and we're sure that each wasfor him an occasion of pleasure and modest gratification. But most of the time youcould find him back in his laboratory, doing the day-in, day-out research that hasbeen his life's work.The new construction and the anniversary events are both exhilarating. We arepleased to take part in commemorating the birth of the University and proud ofthe growth we see going on about us. Physical expansion is essential if the Universityis to maintain its place among the leading teaching and research institutions of theworld.But it is men who determine the quality of an institution. In its seventy-fifthyear the University has been honored by having two of its faculty named Nobelwinners-Dr. Huggins in medicine and Professor Robert Mulliken in chemistry. To the University and its growing faculty these men stand not only asexamples of extraordinary achievement but also as models of earnest dedication tothe everyday task of getting the job done.2 MEDICAL ALUMNI BULLETINAs everyone pretty well knows by now,Charles Brenton Huggins, the WilliamB. Ogden Distinguished Service Professor of Surgery, and Robert S. Mulliken,Ernest De Witt Burton DistinguishedService Professor Emeritus of Chemistryand Physics, received Nobel Prizes inStockholm on December 10. ProfessorMulliken was awarded the prize in chemistry for his molecular orbital theorywhich provided the foundation for almost all subsequent work on the electronic structure of molecules, work towhich he himself has added greatly. Dr.Huggins shared the prize in medicinewith Dr. Francis Peyton Rous, MemberEmeritus of Rockefeller University, fortheir contributions to cancer research.Rous was honored for his investigationsof virus-induced cancer and Huggins forhis work on the relationship of hormonesto prostate cancer.Huggins, director of the Ben MayLaboratory for Cancer Research, cameto the University in 192 7 as one of themembers of the original faculty of thenewly established School of Medicine.He was born in Halifax, Nova Scotia,THE NOBEL AWARDSreceived his M.D. degree from HarvardUniversity in 1924, and took graduatesurgery training at the University ofMichigan. He joined our staff as instructor, became assistant professor in 1928,associate professor in 1932, and professor in 1936. Until his appointment to thedirectorship of the Ben May Lab in1951, he served as head of the urologysection in the department of surgery. Hewas named Distinguished Service Professor in 1962.Dr. Huggins has always combined research with his clinical, teaching, andadministrative responsibilities. Early inhis career he became interested in thephysiology and diseases of the male genitourinary system. In 1939, experimenting on dogs with prostatic tumors, hewas able to separate the prostate glandfrom the urinary tract and thus makebiochemical studies of isolated prostatesecretion. Further research led to hormonal control of the canine tumors andeventually to the application of his findings to prostatic cancer in man. His pioneering studies on the effects of the administration of androgens and estrogens, as well as the effect of orchiectomy, onmetastatic carcinoma of the prostate inman were published in 1941. This provided the first effective therapy for apreviously hopeless disease and stimulated much subsequent research in cancer chemotherapy.Control of cancer by hormones wasbased on two principles postulated byHuggins: 1) that cancer is not necessarily autonomous and self-perpetuating,and 2) that cancer can be sustained andpropagated by hormonal function that isnot abnormal in kind or rate. To provethe effects of hormonal modification oncancer, Dr. Huggins utilized the level ofserum acid phosphatase as a remarkablytrue indicator of the activity of the cancer, and this has continued as the standard in clinical practice. He clearly demonstrated that the theory, then universally held, that all cancers were autonomous and self-perpetuating, was incorrect.In observing patients treated for cancer of the prostate by anti-androgeniccontrol, either through orchiectomy orthe administration of estrogens, it wasMEDICAL ALUMNI BULLETIN 3noted that some did not respond andothers showed redevelopment of theirown hormonal stimulation of the tumor.This led to the concept that the adrenalglands were the next source for production of cancer-sustaining steroids. Thegreat clinical by-product of this researchwas control of metastatic mammary cancer by surgical bilateral adrenalectomy.In 1951, Dr. Huggins, the late DelbertBergenstal, '47, and their associateswere able to demonstrate that patientswith advanced breast cancer could bebenefited by this operation if adequatehormonal substitution was maintainedby the administration of cortisone. Combined with ovariectomy, it proved to beeffective in 30 to 40 per cent of the advanced cases treated. In some instances,the regression of the cancer was remarkably profound and prolonged.Studies of the cases of adrenalectomized patients resulted in the identification of various categories of mammarycancer and introduced the concept thatendocrine glands other than the ovariescan sustain the disease in humans. As aresult, many investigators became involved in research on the control of disseminated cancer of the breast, and manynew approaches to the problem havebeen successfully pursued.Research on mammary cancer washindered by the difficulty of inducingmany types of mammary tumors in animals. Huggins, working on findings ofearlier investigators, succeeded in inducing mammary tumors in the SpragueDawley strain of female rats by administering doses of 3-methylcholanthrene for a period of fifty days. There havebeen many research dividends from thissuccessful induction of mammary tumorsin rats. The greatly decreased time factor has stimulated and hastened investigations of mammary cancer, and demonstration that the carcinogen-inducedtumors are hormone-dependent has increased experimentation in the area ofhost-tumor balance in his and other cancer research laboratories throughout theworld.Dr. Huggins has been honored for acontribution made in 1941 which has, inthe succeeding years, expanded in its investigative and clinical usefulness. HisBen May Cancer Research Laboratory isinternationally recognized as a vigorousand contributing organization. It wouldbe impossible to list all the scientistswho worked with him or were trained byhim, but some of those who have goneon to take key positions at other institutions are:Thomas Dao ('51-'57), chief of thedepartment of breast surgery, RoswellPark Memorial Institute and a memberof the medical faculty of the Universityof New York at Buffalo.Clarence V. Hodges, '40 ('40-'46),professor and head of the section ofurology at the University of Oregon.Eugene P. Kennedy, Ph.D. '49 ('51-'60), Hamilton Kuhn Professor in thedepartment of biological chemistry atHarvard Medical School.Albert L. Lehninger ('45-'52), DeLamar Professor and director of the department of physiological chemistry atJohns Hopkins University. Donald F. McDonald, '43 ('43-'45,'46-'49), professor of urological surgeryand chairman of the division of urologyat the University of Rochester.Paul S. Russell, '47, John HomansProfessor and head of the department ofsurgery at Massachusetts General Hospital, Harvard Medical School.William Wallace Scott, '39 ('39-'46), professor of urology and directorof Brady Urological Institute at JohnsHopkins University.Paul Talalay ('50-'63), John JacobAbel Professor and director of the department of pharmacology and experimental therapeutics at Johns HopkinsUniversity.H. Guy Williams-Ashman ('53-64),professor in the department of pharmacology and experimental therapeuticsand professor of reproductive physiology at Johns Hopkins University.Among those ,still at the Universityare:George E. Block, associate professorof surgery.Dwight Ingle, professor and chairman of the department of physiology.Elwood V. Jensen, Ph.D. '44, American Cancer Society-Charles HaydenFoundation Research Professor in thedepartment of physiology and the BenMay Laboratory.Peter V. Moulder, '45, professor inthe department of surgery.Cornelius W. Vermeulen, '37, professor and head of the urology section ofthe department of surgery and associatedean in the Division of Biological Sciences.The picture below is reprinted from Volume 15, Number 2, (Winter 1959). The lead article in that issue was "Hormone-Dependent Cancer," by CHARLES HUGGINS.The Ben May Laboratory, directed by DR. HUGGINS, occupies the basement and seventh floor of the Goldblatt wing. This is the distin·guished staff in conference: HERBERT JACOBSON, ELWOOD JENSEN, PAUL TALALAY, GUY WILLIAMS-ASHMAN, DWIGHT INGLE, DR.HUGGINS, and KATHERINE SYDNOR.4 MEDICAL ALUMNI BULLETINThe view of Wyler from the steps of the North WingWYLER CHILDREN'S HOSPITAL DEDICATEDThe new Silvain and Arma Wyler Children's Hospital, one of the nation's mostmodem facilities for pediatric medicineand research, was formally dedicated onAugust 28. Special ceremonies for thededication of the hospital's Joseph P.Kennedy, Jr., Mental Retardation Research Center were held on August 31.The dedication was commemorated bya five-day Symposium on the Child directed by Albert Dorfman, '44, chairman of the department of pediatrics,which brought together leaders in thesciences, education, and the law from all over the world. Fifteen hundred guestsattended the eight sessions.The one-hundred bed hospital will beoperated by the Home for DestituteCrippled Children whose affiliation withthe University goes back to 1928 andwhich has maintained the pediatric orthopedic unit of the Hospitals since 1931.Construction was made possible by giftsfrom the Wyler Foundation and Mrs.Wyler. Other major contributors werethe Country Home for Convalescent Childen, a part of the University since 1928,the Chicago Community Trust, and the National Institutes of Health. Federalaid was supplied under the Hill-BurtonAct for hospital construction.The spirit of cooperation and dedication of all who made Wyler's construction possible will be reflected in the operation of the hospital. At the University,as at other leading medical institutions,scientists agree that future progress inmedicine must come from the exchangeof knowledge between clinical practiceand basic research. Wyler's physical andorganizational structure has been plannedto make that interrelationship possible.MEDICAL ALUMNI BULLETIN 5THE SENIOR6 MEDICAL ALUMNI BULLETIN BARTON, LESLIE GEORGETTE LlEBESMANBorn Feb. 22, 1943; Hunter College, B.A., 1963;Intern.: Cook County H., Chicago; Pediatrics; Married; 839 E. 56th St., Chicago; 660 Thwaites Pl.,N.Y.C.BECKER, GERALD LEONARDBorn Oct. 20, 1940; M.LT., S.B., 1962; Intern.:Beth Israel H., Boston; Internal Medicine; Married;196 S. Kenilworth Ave., Elmhurst, Ill.BENENSOHN, HOWARD S.Born Nov. 30, 1940; U. of Chicago, B.A., 1962,M.S., 1966; Intern.: U. of Ill. Res. & Educ. H., Chicago; Undecided; Married; One Child; 533 W. BarryAve., Chicago; 3500 N. Lake Shore Drive, Chicago.BIDWELL, CLIFFORD DONALDBorn Feb. 10, 1941; U. of S. Dakota, B.A., 1963,B.S., 1964; Intern.: Los Angeles Co. Gen. H.; Urology; Unmarried; 115 N. Johnson, Pierre, S.D.BIHARI, MICHAELBorn April 1, 1941; U. of Pa., A.B., 1962; Intern.:Billings H.; Pediatrics; Unmarried; 5715 Drexel Ave.,Chicago; 530 Riverdale Ave., Yonkers, N.Y.BIVIANO, RONALD SANTEBorn June S, 1940; U. of Rochester, A.B., 1962; Intern.: U. of Iowa H., Iowa City; Internal Medicine orPsychiatry; Unmarried; 222 Furnace Road, Ontario,N.Y.BLACKSTONE, EUGEN� HUBERTBorn Oct. 7, 1941; graduate student in physiology,U.S.P.H.S. fellow in surgery, Billings H.; Surgery;Unmarried; A.O.A.; Route #4, Circleville, Ohio.BLOCK, JEFFREY FRANCISBorn Dec. 13, 1940; Georgetown U., B.S., 1962; Intern.: Wesley Mem. H., Chicago; Undecided; Unmarried; 180 E. Delaware, Chicago.BROWNSTEIN, MICHAEL LEWIS. Born May 4, 1941; U. of Chicago, B.S., 1962; Intern.: Cedars of Lebanon H., Los Angeles; Surgery;Married; 8823 Forest View Rd., Skokie, Ill.CARPENTER, JOHN KEELEYBorn June 5, 1940; Oberlin College, A.B., 1962; Intern.: U.S.P.H.S. H., Brighton, Mass.; Psychiatry;Married; 4717 Larchwood Ave., Philadelphia.CHERNOCK, DEBORAH FRANCESBorn June 24, 1942; U. of Pa., B.A., 1962; Intern.:Children's H., Buffalo, N.Y.; Pediatrics; Unmarried;1820 Wynnewood Rd., Philadelphia.CHUNG, GEORGE KAU TAlBorn Dec. 26, 1941; Stanford U., B.S., 1962 j Intern.: Los Angeles Co. Gen. H.; Surgery; Unmarried;5295 Kalanianaole Highway, Honolulu.CRAWFORD, HAL WAYNEBorn July 9, 1940; U. of Ariz., B.A., 1962; Intern.:Tucson Med. Center, Tucson, Ariz. j Psychiatry; Unmarried; Box 146, Cottonwood, Ariz.DE VORE, JAY SAMUELBorn May 7, 1942; Intern.: Wesley Mem. H., Chicago; Obstetrics and Gynecology; Married; A.O.A.;180 E. Delaware St., Chicago; 5504 S. Madison St.,Hinsdale, Ill.DOMINGUEZ, RICHARD HENRYBorn Sept. 13, 1941; Intern.: U. of Washington H.,Seattle; Surgery; Married; 5323 W. Ohio St., Chicago.CLASS OF 1966DUBAN, STEWART LOUISBorn Sept. 29, 1940; U. of Michigan, B.A., 1962;Intern.: U. of Calif. H., The Medical Center, Los Angeles; Pediatrics or Psychiatry; Married; 512! Veteran Ave., Los Angeles.EL VOVE, ROBERT MORTONBorn Oct. 18, 1941; U. of Michigan, B. A., 1.962;Intern.: Kaiser Foundation H., San Francisco; Psychiatry; Married; 1316 W. Fargo, Chicago.FRANKEL, JEFFREYBorn Sept. 1, 1941; Intern.: Mt. Sinai H., N.Y.C.;Neurology; Married; A.O.A.; Mt. View Road, R.D.#1, Washington, N.J.GOLDSTEIN, GARY WILLIAMBorn Nov. 11, 1942; U. of Chicago, B.A., 1963; Intern.: U. of Minnesota H., Minneapolis; Pediatrics;Unmarried; A.O.A.; 7400 N. Kilbourn, Skokie, Ill.GUMBINAS, MARIABorn Feb. 25, 1942; U. of Chicago, B.A., 1963; Intern.: Grace-New Haven H., New Haven, Conn.; Pediatrics; Unmarried; 5310 S. Campbell St., Chicago.HAINES, EDWARD TOYBorn Oct. 14, 1941; Intern.: Blodgett Memorial H.,Grand Rapids, Mich.; Surgery; Married; One child;708 Cowles A venue, Joliet, Ill.HIRZ, RONALD H.Born June 5, 1942; George Washington U., B.A.,1963; Ph.D. candidate, dept. of chemistry, U. of Chicago; Married; 835 E. 56th St., Chicago.HOPKINS, DONALD ROSWELLBorn Sept. 25, 1941; Morehouse College, B.S., 1962;Intern.: San Francisco Gen. H.; Tropical Medicine;Unmarried; 2599 N.W. 50th St., Miami, Fla.HOPPS, CHRISTOPHER ROBINBorn March 2, 1941; Swarthmore College, B.A.,1962; Intern.: U.S.P.H.S. H., Seattle; Neuropsychiatry; Married; Capital Park N-l, 800 Fourth St., S.W.,Washington, D.C.ILLES, JAMES MANFREDBorn Jan. 16, 1941; Oberlin College, A.B., 1962; Intern.: Billings H.; Pediatric Neurology; Unmarried;5715 Drexel Ave., Chicago; 450 Lakeside Pl., Highland Park, Ill.KARASICK, JEFFREY LOUISBorn May 22, 1942; Intern.: Billings H.; Neurosurgery; Married; 1607 E. 50th Pl., Apt. 90, Chicago;820 Oakton, Evanston, Ill.KELLER, ROBERT WESLEYBorn April 1, 1940; Hanover College, B.A., 1962;Intern.: U. of Wisconsin H., Madison; Internal Medicine; Unmarried; 8225 N. Whitney Rd., Milwaukee.KRIVO, JAMES MICHAELBorn Jan. 2, 1941; U. of Chicago, B.S., 1962; Intern.: Maimonides H., Brooklyn, N.Y.; Dermatology;Married; 1385 Deerfield Pl., Highland Park, Ill.KRONE, RONALD JAYBorn Feb. 13, 1942; U. of Michigan, B.S., 1962; Intern.: Billings H.; Internal Medicine; Married;A.O.A.; 5427 University Ave., Apt. 2-D, Chicago; 7044Kilpatrick, Lincolnwood, Ill.KURNICK, JOHN EDMUNDBorn Feb. 9,1942; Harvard College, B.A., 1962; Intern.: U. of Washington H., Seattle; Medicine; Unmarried; 12402 Janet Circle, Garden Grove, Calif.MEDICAL ALUMNI BULLETIN 7THE SENIOR8 MEDICAL ALUMNI BULLETIN LEAF, NORMANBorn Sept. 16, 1941; Intern.: Stanford-Palo Alto H.Center; Surgery; Married; A.O.A.; 267 Curtner, Apt.5, Palo Alto; 7755 Luella Ave., Chicago.LEPAWSKY, MICHAELBorn Sept. 10, 1937; Lawrence College, A.B., 1959;Intern.: Vancouver General H., U. of British Columbia, Canada; Undecided; Unmarried; 2570 Cedar St.,Berkeley, Calif.MARGOLIS, RICHARD U.Born Sept. 7, 1937; U. of Chicago, B.S., 1959, Ph.D.,1963; Instructor, Dept. of Pharmacology, New YorkU.; Married; 6640 Forest Glen Road, Pittsburgh.MILLER, GLENN HOWARDBorn Jan. 8, 1942; U. of Iowa, B.A., 1962; Intern.:Jackson Memorial H., Miami, Fla.; Psychiatry; Married; 7355 N. Winchester Ave., Chicago.MORETTI, JOSEPH ANTHONYBorn Dec. 10, 1941; Intern.: Los Angeles Co. Gen.H.; Otolaryngology; Unmarried; 2013 N. 76th Ave.,Elmwood Park, Ill.MUELLER, PATRICIA ANNBorn Oct. 19, 1940; Earlham College, B.A., 1962;Intern.: Michael Reese H., Chicago; Psychiatry; Unmarried; 5333 Dorchester Ave., Chicago; 816 GlenStone Lane, Dallas, Texas.MURRAY, JOEL ELISABETHBorn May 23, 1941; U. of Chicago, B.S., 1962; Intern.: U. of Washington H., Seattle; Neurology; Unmarried; A.O.A.; 1910 E. First St., Bloomington, Ind.NEVIS, HAROLD CHAIMBorn June 1, 1933; Intern.: Billings H., InternalMedicine; Unmarried; 5704 Harper, Chicago.PIERCE, CARL WILLIAMBorn Oct. 2, 1939; Colgate U., A.B., 1962; U. ofChicago, Ph.D., 1966; Intern.: U. of Colorado Med.Center, Denver; Pathology; Married; A.O.A.; 2500Newport, Denver; 8838 Ridge Road, Gasport, N.Y.RtMPtLA, JULIAN JOHNBorn April 19, 1940; Knox College, B.A., 1962; Intern.: Evanston H.; Internal Medicine; Married;3903 N. Monticello, Chicago.RODNITZKY, ROBERT LEEBorn Aug. 17, 1941; U. of Chicago, B.S., 1963; Intern.: U. of Iowa H., Iowa City; Internal Medicine orNeurology; Unmarried; 46 N. Waller St., Chicago.ROSENBLUM, DANIELBorn May 14, 1940; U. of Chicago, B.S., 1962; Intern.: Beth Israel H., Boston; Internal Medicine;A.O.A.; Married; 6686 Thirty-Second St., N.W.,Washington, D.C.RUSCHHAUPT, DAVID GEORGEBorn Feb. 25, 1940; Harvard College, B.A., 1962;Intern.: Billings H.; Pediatrics; Married; 5656 Drexel,Chicago; 648 Harwick Rd., Strafford-Wayne, Pa.SHELANSKI, MICHAEL LEABorn Oct. 5, 1941; U.S.P.H.S. postdoctoral fellow,dept of biophysics, U. of Chicago; Neuropathology;Married; One Child; 5557 Drexel Ave., Chicago; 651Ashbourne Rd., Cheltenham, Pa.SNYDER, ALAN LEIGHBorn June 7, 1940; M.LT., S.B., 1962; Intern.:Cleveland Metropolitan Gen. H; Internal Medicine;Married; 930 Gates Ave., Norfolk, Va.CLASS OF 1966SVOBODA, LOIS VATNEBorn Oct., 16, 1939; Evangel College, B.S., 1961;Intern.: St. Francis Hospital, Evanston, Ill.; GeneralPractice; Married; Two children; 2338 Prairie Ave.,Evanston; 1369 Alina St., Elizabeth, N.J.TAUB, ARNOLD ELIBorn Sept. 5, 1941; U. of Michigan, A.B., 1962; Intern.: Children's Mem. H., Chicago; Pediatrics; Unmarried; 5006 Dorchester Ave., Chicago; 1339 Greenleaf Ave., Chicago.TERMAN, GERALD PAULBorn June 21,1940; Miami U., B.A., 1962; Intern.:Kaiser Foundation H., San Francisco; Psychiatry;Married; 4145 Eastway Rd., South Euclid, Ohio.TOM, BETTY LOUBorn June 4, 1940; Stanford U., B.S., 1962; Intern.: Bronx Municipal H. Center, N.V.; Surgery;Unmarried; A.O.A.; 3456 A Keanu St., Honolulu.TSOULOS, NICHOLAS GEORGEBorn Dec. 7, 1940; U. of Chicago, B.S., 1962; Intern.: U. of Colorado Med. Center, Denver; Pediatrics; Unmarried; 6128 N. Kilpatrick Ave., Chicago.TURNER, DAVID AVERYBorn May 5, 1940; Wesleyan U., B. A., 1962; Intern.: U. of Oregon Med. Center, Portland; Psychiatry; Unmarried; 2510 Sheridan Rd., Evanston, Ill.TWEET, FRED ANDREWBorn Nov. 22, 1939; U. of S. Dakota, B.A., 1961,M.A., 1962; Intern.: U. of Kansas Med. Center; Kansas City, Kan.; Pathology; Married; One child; 3711Genessee, Kansas City, Mo.; 4345 Grand Ave., DesMoines, Iowa.ULRICH, WESLEY DAVIDBorn May 25, 1941; Houghton College, B.S., 1962;Intern.: Hennepin Co. Gen. H., Minneapolis; Pathology; Unmarried; A.O.A.; 2509 S. Cypress St., SiouxCity, Iowa.WATERS, ROBERT L.Born Dec. 9, 1941; Indiana U., A.B., 1962; Intern.:U. of Calif. H., San Francisco; Orthopedics; Unmarried; 909 S. Highland, Bloomington, Ind.WEINGER, JESSE MYRONBorn Feb. 22, 1943; U. of Chicago, B.A., 1962; Infern.: Bronx Municipal H. Center, N.Y.C.; Orthopedic Surgery; Unmarried; 23 Flower Rd., ValleyStream, N.Y.WONG, SHIU-LOONG RAYMONDBorn Jan. 25, 1942; U.C.L.A., B.S., 1962; Intern.:U. of Calif. H., The Medical Center, Los Angeles;Pediatrics; Unmarried; 526 Thirty-fifth Ave., SanFrancisco.YAMASHIRO, KENNETH MATSUJIBorn Oct. 20, 1940; U. of Hawaii, A.B., 1962; Intern.: Maimonides H., Brooklyn, N.Y.; Internal Medicine; Married; 1928 Kalihi St., Honolulu.YOUNG, JOHN BURTONBorn May 9, 1939; Iowa State U., B.S., 1961; Intern.: Ancker H., St. Paul; ENT; Married; 2040 Wilson Ave., Apt. 36, St. Paul; 424 Kingbard Blvd., Waterloo, Iowa.ZAJTCHUK, JOAN ELAINE TRACZBorn Nov. 3, 1938; U. of Chicago, B.S., 1960; Intern.: Billings H.; ENT; Married; 5605 MarylandAve., Chicago; 1629 N. Linder Ave., Chicago.MEDICAL ALUMNI BULLETIN 9SENIOR SCIENTIFIC SESSIONPraseodymium- 144: A ShortLived Strong Beta EmitterBy GERALD L. BECKERSurgeryThe radioisotope praseodymium-144has a half-life of 17.5 minutes and 98per cent of disintegrations yield f3-radiation of Emnx = 3.0 mev. Theseprope.rties sugge.st that this isotope wouldbe suitable for mtracavity irradiation. Avolume of solution not less than 1 cm inany dimension and containing 1 mc/mlof Pr-144 activity would deliver a doseof approximately 500 rads/ cm2 over aone-hour period to adjacent tissue surfaces with negligible dosage to any structure separated from the source by morethan 1.6 em of intervening tissue. Afterthree hours, less than 0.1 per cent of theoriginal activity would remain constituting minimal hazard even if t;anslocation or systemic dissemination of the isotope were to occur.Because of its rapid decay, Pr-144must be produced at or near the area tobe irradiated. Since Pr-144 is the soleproduct of the decay of 285-day cerium-144, a stored sample of the latter contains an a�proximately equal activity oft?e sho�t-hve?, daughter. This "equilibrium mixture, a by-product of reactionfissi.on, is. ple?tifully and inexpensivelya�aIlable m high specific activity ("carner-free") .This investigation was concerned with astudy of the separation and processing ofPr-��4 r= a. laboratory supply of theequilibrium mixture, The product is anon-toxic, carrier-free solution of Pr-144in therapeutic amounts, with minimalcontamination from the long-lived Ce-144. Because the radioactive equilibriumis quickly re-established, the separationcan be repeated as often as every 1 to 2hours without loss of yield.Inhibition of Tumor Dissemination Utilizing Antibodies tothe "Cancer CoagulativeFactor"By HOWARD S. BENENSOHNPathologyThe possible influence of the "coagulation mechanism" on tumor metastaseswas investigated in Sprague-Dawley rats10 MEDICAL ALUMNI BULLETIN injected intravenously with MurphySturm lymphosarcoma cells. Groups oft�ese animals were treated for four daysWIth one of the following substances:Heparin, Fibrinolysin, rabbit anti-ratfibrino�en, Epsilon amino caproic acid,protamme sulfate, normal rabbit gammaglobulin, and a water-soluble substanceoriginally described by O'Meara and co�workers in Ireland, and extracted fromthe Murphy lymphosarcoma. It is capable of coagulating a plasma buffer mixture in vitro and has been called the"�ancer Coagulative Factor" (CCF). Inthis study both the CCF and rabbit antiCCF gamma globulin were employed.Onset of paralysis of at least one limband .death of the tumor-bearing animalprovided the two endpoints for evaluation of anti-tumor therapy.Results revealed that tumor controlsand animals treated with normal rabbitgamma globulin usually developed paralysis within four days, and death foll?wed within fourteen days after injection of tumor cells. Rats receiving CCFor E-amino caproic acid tended to develop paralysis earlier, died earlier, andhad no spontaneous regressions. Treatment of tumor-bearing rats with Fibrinolysin, Heparin, or rabbit anti-rat fibrinogen produced results similar to thoseobserved in animals treated with normalrabbit gamma globulin. In contrast, ofth?se treated with rabbit anti-CCF, onlythirty per cent exhibited paralysis, andonly fifty per cent ultimately died ofdisseminated tumor. The group survival(50 per cent) was twice as long as thatof any of the other groups. Group results with Protamine, an in vitro inhibitor of the CCF, were inconclusive butalso promising.The results may have implications inrelation to tumor metastases and, particularly, in relation to tumor cells released in.to the circulation at surgery.The findmgs support the thesis that atumor helps to produce its own stromaby releasing an as yet unidentified "coagulating" factor. This characteristic oftumor stroma may be deleterious to thenatural defense mechanisms of the body.r Metabolic Acidosis inHypothermiaBy EUGENE H. BLACKSTONESurgeryIn direct blood stream cooling, themuscle masses remain warmer than viscer�l. organs during cooling, while remammg cooler as the rest of the bodysubsequently rewarms. Since a metabolic acidosis is also said to be associatedwith hypothermia, this differential cooling of muscle masses has been incriminated as the source of this metabolicacidosis.To quantitate the metabolic alterations of hypothermia, three indicatorswere used: the buffer base, base excess,and excess lactate cross-bed differences.Th� latter (an indicator of tissue hypOXIa) was correlated with total tissueoxygen consumption to give a valuecalled "percent anaerobic metabolicrate."Procedure: A canine isolated hindlimb perfusion technique was employed.Blood temperature was controlled in aconstant pressure system, and flow wasby demand. During a one and one-halfhour cooling phase (to 16-26° C) and a?ne �nd one-half hour rewarming phasem thirteen dogs, periodic blood sampleswere taken for analysis of pH, P C02,P 02, hemoglobin, lactate, and pyruvate.Results: Basal O2 consumption andflow were within accepted values (thesevalues are quite low in resting muscle).In one-half the dogs, no change in buffer base, base excess, or per cent anaerobic metabolic rate was noted. However,in one-half, an acidosis was noted duringthe cooling phase only. This was immediately reversed as soon as warmer bloodwas provided to the leg. In all cases, buffer values and anaerobic metabolic ratewere restored to normal long beforecomplete rewarming was achieved.These findings are compatible withknown metabolism of resting muscle: itsblood flow and metabolic rates compared to the rest of the body are lowand it has great ability to shift rapidlyfrom aerobic to anaerobic metabolismand back again.Although in some limbs a transientacidosis was indeed noted, we must conclude that by itself it probably does notadd significantly to any metabolic acidosis observed with hypothermia.A Study of Emotional SupportDuring PregnancyBy JOHN K. CARPENTERPsychiatryThis study compares two groups ofpregnant patients who were registered ina prenatal clinic at Chicago Lying-inHospital. The first group was followedthroughout pregnancy, labor and delivery by freshman medical students. Themedical students interviewed the patients and discussed their interviewingexperiences in seminars with staff psychiatrists as part of their introductorycourse in psychiatry. The control group,consisting of fifty prenatal patients fromthe same clinic population, were selectedfrom a series of consecutive deliveriesand did not receive the special interviews.Compared to the control group, theprenatal patients who were followed andinterviewed by freshman medical students:a) Reported feeling less nervous or onedge during pregnancy;b) Reported feeling less worried orconcerned during labor;c) Required less narcotic and tranquilizing medication prior to deliverywhen labor lasted five or more hours.This reduction in required medicationwas positively correlated with increasingnumbers of student interviews.The results presented in this studydemonstrate that important differencesdo occur in the attitudes and behaviorof prenatal patients who receive additional support during their pregnancy.Viral Murine leukemias Cytogenetic Evidence for VirusDependencyBy RICHARD H. DOMINGUEZPathologyCertain RNA viruses cause neoplasianot only by initiation of cancer but alsoby subsequent release of virus from tumor cells and neoplastic transformationof new target cells in the tumor-bearinghost. Such a dual process of viral carcinogenesis is known as virus dependency, and it is based on work with theRous sarcoma virus and the virus ofavian myeloblastosis. We present a cytogenetic analysis of a transplanted andvirus-induced leukemia in rats whichsuggests a similar mechanism for murineleukemogenesis. "Early" and "late" lymphoid leukemias are elicited in rats when viable leukemic cells from AKR mice are injectedintraperitoneally into newborns at birthand two weeks later. The two leukemicforms are distinguished by different sitesof origin and transplantation characteristics of their respective tumor cells. Cellgrafts from the late, thymic forms areconsistently rejected by the original donor strain of AKR mice but grow inadult, isologous rats. Early leukemias arereadily transplantable to AKR mice.These transplantation characteristics suggest that early leukemias represent AKRcells multiplying in the newborn heterologous host, whereas late leukemias arecomposed of rat cells transformed by theleukemogenic virus of AKR mice. If thisassumption is correct, leukemic cellsfrom early and late leukemias should differ in the number, configuration, and sexchromosomes.The respective leukemias were inducedin rats by inoculation of leukemic cellsfrom female AKR mice at birth andtwelve days later. The majority of leukemic cells from early leukemias in ratshad the diploid number (2n = 40), typical telocentric configuration and femalesex chromosomes of the donor mice irrespective of the sex of the recipient. Thechromosomes of late leukemias were numerically and morphologically those ofthe rat and the sex chromosomes corresponded in all cases with the sex of therecipient. Thus, the two leukemic manifestations differed with respect to mode,configuration, and sex constitution ofchromosomes as predicted in the abovehypothesis.Cortisol Binding in Adult andNewborn PlasmaBy RONALD H. HIRZMedicineIn normal adults, only about 10 percent of the total concentration of cortisolin the plasma is in the unbound form,which can penetrate membrane barriersand enter the cells of the body. The remainder is reversibly bound to plasmaproteins, mainly to an alpha globulin,transcortin.In the newborn, the per cent of freeplasma cortisol is much higher, possiblydue to a lower plasma concentration oftranscortin. It is also possible that transcortin levels are normal but that steroidsother than cortisol, which the newbornhas circulating in large quantities, inter- fere with the binding of cortisol by directcompetition.In an attempt to remove endogenoussteroids which might compete with cortisol binding in the newborn, equilibriumdialysis of umbilical cord plasma with atracer amount of tritiated cortisol wascarried out repeatedly until over 99 percent of the endogenous cortisol was removed. There was a small increase fromthe original per cent of tritiated cortisoltracer bound at equilibrium, but the percent bound was much lower than that ofsimilarly treated adult plasma. It wasconcluded that the steroids in newbornplasma do not compete significantly withcortisol binding and that transcortin ispresent in lower concentration or is qualitatively different in some way in thenewborn.The removal of endogenous cortisol byrepeated dialysis mimicked the diurnalvariation in total plasma cortisol in normal adults. It was found that a threefold variation in total plasma cortisolconcentration, similar to what occurs inman during each twenty-four hour period, results in a ten-fold variation inthe free, physiologically available cortisol concentration in vitro.Penetration of the Skin by Schistosome Cercariae: The Role ofCalcium and MagnesiumIonsBy DONALD R. HOPKINSMicrobiologyPresumptive evidence of calcium inthe preacetabular glands of cercariae ofSchistosoma mansoni and Schistosomatium douthitti (a non-human schistosome) has been obtained by vital staining with Alizarin Red S, by the reversalor inhibition of this staining with Versene (EDTA), and by selective stainingof the glands with the Schiff base Gloxalbis (2 hydroxyanil) (or GBHA). Whereas the GBHA technique employed ishighly specific for Ca + +, Versene andAlizarin Red S may chelate Mg+ + andother heavy metal ions as well as calcium.The decrease in invasiveness of S. mansoni and S. douthitti cercariae noted as aconsequence of metal chelation correlated well with earlier reports of an inhibiting effect of chelating agents on theactivity of cercarial enzymes. A similardirect correlation between previouslydescribed effects of various ions on inMEDICAL ALUMNI BULLETIN 11vitro activity of extracted cercarial enzymes and the effects of these ions onpenetration by S. mansoni cercariae, notably the potentiation of enzyme activityand penetrating ability by added Ca + +or Mg+ +, was also noted. Addition ofCa + + or Mg+ + partially restored thepenetrating ability of S. mansoni cercariae exposed to a chelating agent.These data strongly suggest that calcium ions in the preacetabular glands ofS. mansoni cercariae function in a manner similar to that of a co-enzyme or activator to lytic apo-enzymes containedtherein, and also that in this capacity,calcium and/or magnesium ions are essential for successful invasion of the definitive host.It appears that differences in qualityand quantity of heavy metal ions in natural waters may explain variability in intensities of infection in different endemic areas.Hypoglucagonemia: A NewExperimental ModelBy HAROLD C. NEVISMedicineOkuda and Grollman have recently reported that chronic neutral red administered to rats results in metabolic alterations which they suggest may be a resultof specific cytotoxic destruction of thealpha cells of the islets of Langerhansresulting in a state of glucagon deficiency. These claims, although convincing, remain speculative since glucagonlevels were not measured. In the presentstudy, the acute effect of intravenousneutral red was studied in five mongreldogs. Peripheral venous plasma glucoseand radioimmunoassayable glucagon andinsulin levels were determined at varyingintervals after injection of neutral red.Remarkable and rapid elevation inplasma glucose occurred within minutesafter in jection of neutral red andreached levels above 300 mg per cent by30 minutes in some animals. This hyperglycemia was associated with a consistent and early, albeit variable rise in peripheral venous glucagon levels of 2-5mug/ml.Light microscopic analysis of sectionsobtained approximately three hours afterneutral red injection revealed degranulation and vaculization of the alphacells.These studies are similar in reverse tothe metabolic alterations produced withalloxan and suggest that neutral red mayi2 MEDICAL ALUMNI BULLETIN indeed destroy alpha cells with abruptrelease of stored glucagon resulting inhyperglycemia secondary to rapid glycogenolysis. Studies designed to determinewhether the chronic administration ofneutral red will render an animal permanently glucagon deficient are in progress.Effects of Endotoxin on theImmune Response inthe RatBy CARL W. PIERCEPathologyEndotoxins from Gram-negative bacteria are known to enhance the circulating antibody response to certain antigens; however, the mechanism of thisenhancement is unknown. These studieswere undertaken to test the enhancingability of endotoxin in rats and to attempt an explanation of their action. Theantibody response to intravenous bovinegamma globulin (BGG) alone or mixedwith S. typhosa endotoxin (E) weremeasured in intact and splenectomizedrats. BGG stimulated no detectable primary response in intact rats but did stimulate a late 7S response in splenectomized rats. BGG + E stimulated anearly 19S and late 7S response in intactrats, but only an enhanced late 7S response in splenectomized rats. BGG wasas effective as BGG + E for sensitizingintact rats for a secondary response. Theaddition of E to BGG for the secondantigen injection did not significantly alter the secondary response of intact ratsbut enhanced this response in splenectomized rats. These results suggested thatearly 19S antibody was of splenic originand that endotoxin enhanced this response. Injection of rat 19S anti-BGGprior to BGG injection in intact andsplenectomized rats suppressed both theprimary and secondary antibody responses. This indicated that intact ratsproduced small amounts of antibodyafter injection with BGG which inhibited the major antibody response. Removal of the spleen and the source ofthis suppressing antibody allowed expression of an immune response by nonsplenic lymphoid tissue. The response inrats passively immunized and then injected with BGG + E was not suppressed. This indicated that E may enhance antibody production by interferingwith the antibody feedback inhibitionmechanism which controls the immuneresponse. Immunohistochemical Studiesof Ulcerative ColitisBy JULIAN J. RIMPILAMedicine and PathologyConsiderable evidence has accumulated implicating immunologic mechanisms in ulcerative colitis. However,the application of immunohistochemicaltechniques has led to conflicting reportsregarding the demonstration of circulating antibodies to colonic mucosal epithelium in patients with this -disease. Inthis study several different variables involved in fluorescent antibody conjugation were evaluated using the direct immunofluorescent antibody technique withautologous and homologous ulcerativecolitis sera and tissues and appropriateserologic and tissue controls.Globulin fractions of whole serum wereobtained by precipitation with cold saturated ammonium sulfate and gel filtrationwith a Sephadex G-50 column. Theseglobulins then were conjugated withfluorescein isothiocyanate and subjectedto DEAE-cellulose column chromatography with gradient elution. Globulin conjugates from a given serum were prepared to differ as to (a) fluorescein:protein (F :P) ratios, (b) uniformity oflabeling, or (c) final protein concentrations.Immunologically nonspecific stainingof colonic mucosal epithelial cells andother colonic components was observedwith F:P ratios exceeding 3.7 X 10-3,uneven labeling, or final protein concentrations greater than 1.5 mg/ml. Usingoptimum conjugation conditions withserum globulins from nine ulcerative colitis patients, no immunospecific stainingof autologous or normal colonic mucosalglands was demonstrated. Some of theseulcerative colitis conjugates did producespecific immunofluorescence associatedwith the cytoplasm of lymphocytes, plasma cells, neutrophiles or eosinophiles inautologous and homologous ulcerativecolitis colonic tissue, but not in controltissues. The source and nature of thisapparent antigen were not identified although these findings further implicateimmunologic mechanisms in ulcerativecolitis. Since non-immunospecific staining of colonic mucosal glands was induced, technical considerations wereshown to be critical to the reproducibility and interpretation of immunofluorescent results.The Presence of Complement (C')Components in ProperdinPreparationsBy DANIEL ROSENBLUMMedicineProperdin (P) prepared from serumby zymosan absorption at 1SoC andsubsequent elution was analyzed forthe presence of complement (C') components by techniques involving theformation and hemolysis of various sensitized red cell-complement componentintermediates (EAC' ... ); C'l, C'2,C'3 (f31C globulin) and C'S (f3lf globulin) were found. C'l esterase activitywas also detected, utilizing an amino acidester as substrate. Immunoelectrophoretic analysis revealed the presence of f31cand f3lf globulin. Paroxysmal nocturnalhemoglobinuria red cells (PNHE) andtrypsinized red cells (TE) exposed to Pwere sensitized to lysis by dilute EDTAserum; the presence of C'6 markedlyenhanced this effect. Since partially purified preparations of C'S and C'6 havebeen shown to form the intermediatecomplexes PNHEC'5,6, these findingsare also consistent with the presence ofC'S in properdin. In addition, the enhancement of PNHE acid serum lysis byproperdin was kinetically similar to thateffected by equivalent amounts of C'lesterase; preincubation of serum withC'l esterase or properdin led to lossof enhancing capacity. Restoration ofPNHE lytic capacity to RP serum byproperdin could not be reproduced usingC'l esterase, C'3, C'S, or C'6 alone orin combination.These findings support and extend theconcept that zymosan interaction withserum yields immune complexes ofzymosan, antibody and C' components.Activity of properdin in immune lysisand PNHE lysis may be attributed tothe presence of complement componentsin properdin preparations.The Conversion of Hematin toBile Pigment in the RatBy ALAN L. SNYDERMedicineThe mechanism underlying the breakdown of hemoglobin and other hemeproteins to bile pigment in vivo is notunderstood. In particular, it is unknownwhether hematin is an intermediate inthis conversion. The metabolism of C14_hematin was studied in rats with an external bile fistula. Injected C14-hematin was converted to C14-bilirubinwith an efficiency of fifty to seventyper cent. The rate of disappearance ofC14-hematin from the plasma varied,depending on whether the pigment wasadministered bound to human or tomurine albumin. Formation of C14_bilirubin appeared to occur in the liveronly. Both the efficiency and kinetics ofthe conversion of hematin to bilirubinwere similar to those observed with comparable amounts of hemoglobin. Thisfinding does not provide proof thathematin is a true intermediate in themetabolism of hemoglobin. It doesindicate, however, that the ferri-protoporphyrin ring can readily be cleavedwithout being attached to native oradulterated globin. This leaves open thepossibility that splitting of heme andglobin may represent the first degradative reaction in hemoglobin catabolism,and that an iron-containing porphyrinmay be a metabolic intermediate in theformation of bile pigment.Morphologic Distributionof Leprous Lesions inPeripheral NervesBy KENNETH M. YAMASHIROPathologyThe predominance of leprous lesionson the face and extremities has led tothe theory that Mycobacterium lepraehas a growth preference for temperatureslower than 37° C. This concept has beenextended to explain peripheral nervelesion localization. Thus Brand (1964)states, "Most nerves which are withinhalf an inch of the skin and are notcovered by a muscle belly seem liableto infiltration and edema." In additionhe says that deeper nerve trunks ". . .are not infiltrated .... "Seven sets of complete ulnar andsciatic nerves and seven other partialsets from autopsies of patients withlepromatous leprosy were diagrammed,and sectioned serially (934 blocks) usingsaffron trichrome, Kliiver-Berrera luxolfast blue, and acid fast stains. Cutaneousnerves and peripheral nerves from thesame cases revealed identical histopathologic morphology. The ulnar nervesexhibited lepra cell infiltrates throughout their course. The areas of most intense inflammation were in the ulnarnerve at the elbow and wrist. The areasof inflammation often followed thecourse of intraneural blood vessels and showed skip areas. The sciatic nerveshowed lepra cell infiltration throughout its common peroneal and posteriortibial branches, while atrophy withoutinflammation was observed in the sciaticnerve proximal to the origin of these twomain nerve branches. The areas of mostintense inflammation in the sciatic nervewere found along the lateral tibia andat the heel.Similar examination of one case oftuberculoid leprosy revealed epithelioidcell infiltration throughout both ulnarand sciatic nerves with destruction ofnerve axons and myelin sheaths.The findings that lepromatous infiltrations occur throughout the course ofthe ulnar and sciatic nerves indicate thatthe infection may propagate and thrivewhether or not lower temperatures arecritical to the initiation of the infection. Factors of locus minoris resistentiaeare a possible explanation of more intense inflammation at exposed areas suchas elbow, wrist, and heel.FISHBEIN CHAIR ENDOWEDMrs. Morris Fishbein has presentedthe University with a gift of two hundred thirty thousand dollars to establisha professorship in the history of biologyand medicine in honor of her husband.The chair will be in the University's department of history and will serve to extend the understanding of the interrelationship of the social processes and thelife sciences, a field in which Dr. Fishbein has long been interested. An additional gift of twenty thousand dollarshas already been contributed by MedicalW orld News and further funds are beingsought.The Fishbeins live in the Hyde Parkarea and have been strong supporters ofthe University and the School of Medicine. The Fishbein Medical Library Endowment Fund was established to purchase scientific journals, books, and other needs for Billings Hospital Libraryand its medical history library. To commemorate Dr. Fishbein's sixty-fifthbirthday in 1954, his wife and friendsestablished the Morris Fishbein ReadingRoom in Billings.Dr. Fishbein received his B.S. degreefrom the University in 1910 and hisM.D. from Rush Medical College in1912. Internationally known for his workas a medical author and editor, he is anemeritus clinical professor from bothThe University of Chicago and the University of Illinois medical schools.MEDICAL ALUMNI BULLETIN 13REUNION, 1966ARCHIE LIEBERMAN recording our picturestory of the Reunion Banquet.EUGENE P. KENNEDY, Ph.D., '49, Faculty 1951-1960, in conversation with JOSEPH P.EVANS, professor of neurosurgery. Kennedy, Hamilton Kuhn professor of biologicalchemistry at Harvard University, was presented for a Distinguished Service Award bySAMUEL B. WEISS, professor of biochemistry.JOHN R. HOGNESS, '43, Dean of the School of Medicine at the University of Washing·ton, was presented for a Distinguished Service Award by DEAN LEON O. JACOBSON, '39.Dr. Jacobson has just relinquished the microphone to Dr. Hogness. Seated from left toright at the speakers' table are JEFFREY FRANKEL, speaker for the Senior Class; DOUG·LAS BUCHANAN, professor of pediatrics who was chosen by the Seniors to administerthe Hippocratic Oath; EDWIN F. HIRSCH, Rush '16, president of the Alumni Association;and SIDNEY SCHULMAN, '46, vice-president.14 ME 0 I CAL A L U M NIB U LL E TINCLARENCE C. LUSH BAUGH, '48, MRS.LUSHBAUGH, and ROBERT J. HASTERLlK,Rush '38. Dr. Lushbaugh, chief of appliedradiobiology at Oak Ridge Institute ofNuclear Studies, was presented for the Distinguished Service Award by Dr. Hasterlik,professor of medicine.PAUL RUSSELL, '47, John Homans professorof surgery at Harvard Medical School andchief of general surgical services at Massachusetts General Hospital, was presentedfor the Distinguished Service Award byRene B. Menguy, professor and chairmanof the department of surgery.JESSIE BURNS MACLEAN, executive secretary of the Alumni Association, was madean honorary alumna and presented with aGold Key by SIDNEY SCHULMAN, '46,professor of neurology. Standing at thespeakers' table are PRESIDENT HIRSCH,SIDNEY SCHULMAN, ALLAN KENYON, andJOSEPH J. CEITHAML.ME 0 I CAL A L U M NIB U L LET I N 15ALLAN T. KENYON, Rush '26, professor ofmedicine, was the banquet speaker. Hisspeech, "Tomorrow and Tomorrow," wasdirected to the graduating class...HAROLD HOPKINS, '66, has just been presented with the Borden Award by JOSEPHJ. CEITHAML, Ph.D. '41, Dean of Students. MCCLINTOCK AWARDJavad Hekmatpanah, assistantprofessor of neurosurgery, waschosen by the class of 1966 to bethe recipient of the five hundreddollar McClintock Award for outstanding teaching. Dr. Hekmatpanah was born in Iran and receivedhis M.D. degree from the University of Tehran. He served internships in Tehran and at Mount SinaiHospital in Chicago. Following athree-year residency in neurologyat the University of Wisconsin, hejoined our staff as a resident inneurosurgery in 1961.16 ME 0 I CAL A L U M NIB U L LET IN ..WALTER LINCOLN PALMER, Rush '2J,Richard T. Crane professor emeritus of thedepartment of medicine, returning to histable. He was presented for the Gold Keyby HANS HECHT, professor and chairmanof the department of medicine.THE CLASS OF 1916Testimonials were presented to ninemembers of the Class of 1916 who returned to celebrate their fiftieth anniversary at the Reunion Banquet.Arthur K. Baldwin has been in general practice in Carrollton, Illinois since1920.Robert L. Elliston was in generalpractice with his brother in La Salle, Illinois before moving to Fort Lauderdale,Florida in 1934. He retired in 1959.Edwin F. Hirsch, associate professoremeritus in pathology from Chicago andRush Medical College, and emeritus director of pathology at St. Luke's hospital, is still active as director of theclinical laboratories for Columbus,Cuneo, and St. Francis Cabrini hospitalsin Chicago. He served as the presidentof the Alumni Association for 1965-66and had the pleasure of presenting theirtestimonials to his classmates.Edwin Walter Hirsch is still activein the practice of urology in Chicago.Ralph O. Porter was dean and pro·fessor of pharmacology at the Universityof Utah from 1923 to 1930 before studying ophthalmology and otolaryngologyat the University of California. In 1940he returned to Logan, Utah, where he isstill active in EENT practice.Maurice P. Rogers continues in active practice of general surgery in Rockford, Illinois.Conrad O. Rogne has been in generalpractice in Ettrick, Wisconsin since 1923.Edmund C. Roos has retired fromthe practice of general surgery in Decatur, Illinois.Clinton D. Swickard has been ageneral practitioner in Charleston, Illinois since 1919.All the doctors attending the ReunionBanquet were accompanied by theirwives except Dr. Elliston who came withhis daughter, Miss Margaret Elliston.Thirty-four of the forty-seven livingmembers of the class responded to o,!rrequest for information on their careersand current activities. Nineteen are stillat least partly active in medical practice,and their professional activities havebeen wide-ranging.Martha Jane Gifford, a specialist intropical medicine, spent her entire careerat Moulmein Christian Hospital in Burma. Edward Brunemeier was a medical missionary in southwest China from1917 to 1927. Brigadier General Raymond Dart, a pathologist, retired fromarmy service in 1964. Nine members ofthe class have been associated with aca- Seated at the further Rush table are DR. and MRS. PORTER, DR. and MRS. ROOS,DR. and MRS. ROGERS, and MRS. EDWIN F. HIRSCH. Around the foreground table areDR. ELLISTON and his daughter, DR. and MRS. ROGNE, DR. SWICKARD, DR. EDWINW. HIRSCH, MRS. SWICKARD, MRS. EDWIN W. HIRSCH, MRS. BALDWIN, and DR.BALDWIN.demic medicine, and the others were engaged in almost all the various specialtiesand in general practice. Among themthey have fifteen children who are graduates of medical schools-four of them,including the only daughter who is a doctor, graduated from our medical school.The variety of their medical careers isparalleled by the variety of their extramedical interests which include hunting,fishing, boating, golf, travel, cattle raising, gardening, cooking, writing, music,and amateur theatricals. But more striking than the natural differences thatmark the lives of the individual classmembers has been their constructive involvement in the communities in whichthey live. They have served on theboards of their local hospitals, as officersin the local medical societies, and havebeen active in their local church andcivic organizations. Their vigorous liveshave been devoted to the practice ofmedicine and service to their fellowmen. We were pleased to have so manyrepresentatives of the class at the banquet. We have come to expect solidachievement and earnest dedication inthe lives of our older Rush graduatesand know that they serve both as example and encouragement to the graduatingclass who share the banquet honors withthem.Testimonials and copies of their classmates' biographical sketches were mailedto the following class members whocould not attend the Reunion:Clarence W. Adams, San Francisco.Edward H. Brunemeier, Placentia,California.William Burk, Chicago. Angus L. Cameron, Minot, NorthDakota.Henry H. Cox, La Salle, Illinois.Raymond O. Dart, Falls Church, Virginia.James R. Elliott, Pasadena, California.Martha Jane Gifford, Fairport, NewYork.James P. Gillis, Los Angeles.Fred L. Glascock, Carmel, California.Phyllis Greenacre, New York City.Roll O. Grigsby, Ashland, Wisconsin.Earle K. Hallock, Freeport, NewYork.William R. Jackson, Kansas City,Missouri.Owen King, Clearwater, Florida.Max M. Kulvin, Miami, Florida.Wilmer D. McGrath, Grand Island,Nebraska.Elmer L. Mertz, Lake Helen, Florida.Claude W. Mitchell, Bradenton,Florida.Milton E. Rose, Barrington, Illinois.Harold A. Rosenbaum, Chicago.Paul H. Rowe, Minot, North Dakota.John A. Saari, Portland, Oregon.Stephen A. Schuster, EI Paso, Texas.Elmer G. Senty, Davenport, Iowa.William Leroy Smith, Salt LakeCity.William W. Stevenson, Flint, Michigan.Charles K. Stulik, Union Pier, Michigan.William A. Taylor, Portage, Wisconsin.Charles R. Tompkins, Grafton,North Dakota.Ralph G. Willy, Portal, Arizona.ME Die A L A L U M NIB U L LET I N 17SENIOR HONORS AND AWARDSFive members of the class of 1966were graduated with honors. They were:Eugene Blackstone, Ronald Krone,Joel Elisabeth Murray, Carl Pierceand Daniel Rosenblum.Donald Hopkins won the BordenAward for his research paper: "Penetration of the Skin by Schistosome Cercariae: The Role of Calcium and Magnesium Ions." He intends to specializein tropical disease and part of his research, under the direction of the department of microbiology, was conducted inPanama.The Medical Alumni Prize for excellence in the delivery of a paper at theSenior Scientific Session was awarded toHarold C. Nevis for his paper: "Hypoglucagonemia: A New ExperimentalModel." His research was conducted inthe department of medicine.Daniel Rosenblum received the J 0-seph A. Capps Prize awarded annually toa senior medical student for outstandingproficiency in clinical work. One of the Sheard-Sanford Awards ofthe American Society of Clinical Pathologists was won by Howard Benensohnfor his study: "Inhibition of Tumor Dissemination Utilizing Antibodies of the'Cancer Coagulative Factor.''' Only tena wards are made each year in nationalcompetition. The Society'S Bausch andLomb Gold Medal was awarded to CarlPierce for his paper: "Effects of Endotoxin on the Immune Response in theRat."Awards from the American MedicalWomen's Association to outstandingwomen graduates were presented to JoelElisabeth Murray and Betty Lou Tom.William Stell, a junior medical student, won the Gellhorn Prize in neurophysiology. Sherman David Holtzman,a sophomore, was awarded the Harry A.Ginsburg Memorial Prize in physiology.Both students are on the combined M.D.Ph.D. program, Stell in anatomy andHoltzman in physiology. A.O.A. ELECTIONSThe eight members of the senior classelected to membership at the May 11meeting of the Alpha Omega Alpha were:Jay DeVoreJeffrey FrankelGary GoldsteinRonald KroneNorman LeafDaniel RosenblumBetty Lou TomWesley UlrichThree other members of the class,Eugene Blackstone, Joel ElisabethMurray and Carl Pierce, were elected tomembership in their junior year. DavidHorwitz, Howard L. Kirz, John McMahon and Deborah Scherz wereelected from the current junior class.Dr. Irving London, professor andchairman of the department of medicineat Albert Einstein Medical College, presented the A.O.A. Lecture. He spoke on"Hemoglobin Synthesis."OFFICERS OF MEDICALALUMNI 1966-67John R. Lindsay, Thomas D. JonesProfessor of surgery, is president of theAssociation this year. He took his M.D.degree in 1925 from McGill Universityand joined our faculty in 1928. He washead of the section of otolaryngologyfrom 1940 to 1966.Dr. Lindsay is internationally knownfor his work on the balance mechanismof the inner ear and has contributed significantly to research on deafness relatedto virus diseases. In 1961 he helped establish the Temporal Bone Banks Centerfor Ear Research and was named the national director. By 1964 the growth ofthe program made it necessary to establish three more centers; the original oneat the University became the midwesternheadquarters. Dr. Lindsay has continuedto direct the national program in cooperation with the directors of the otherthree centers.He has served as president of theAmerican Academy of Ophthalmologyand Otolaryngology and of many otherelite otolaryngological societies. Hisachievements have brought him many18 ME 0 I CAL A L U M NIB U L LET IN LINDSAYdistinguished honors and awards forteaching and research. Students he hastrained have gone out from the University to head otolaryngology sections atmany important medical schools. TheAssociation is pleased that he has foundtime in his busy career to head our organization for the coming year. Richard L. Landau (M.D. '40, Washington University), this year's VicePresident, received his internship andresidency training here and, with the exception of three years' war service in theArmy Medical Corps, has been on thestaff since 1940. He is professor of medicine and director of the Clinical Research Center.Robert J. Hasterlik, Rush '38, Secretary, has long been an active member ofthe Alumni Association. He was VicePresident from 1954 to 1956, Treasurerfrom 1958 to 1959, and is a member ofthe editorial board of the Bulletin. Heis a professor in the department of medicine and Argonne Cancer Research Hospital.Burton J. Grossman, '49, associateprofessor of pediatrics and medical director of La Rabida Institute, is Treasurer.Duncan A. Holaday, '43, professorof surgery and head of the section ofanesthesiology, and Frank W. Newell,professor of surgery and head of the section of ophthalmology, were elected tothree-year terms on the Council. Dr.Newell took his M.D. degree from Loyola University in 1939 and has been amember of our faculty since 1953.PROFESSORSHIP WILLHONOR WALTER PALMERFriends, colleagues, and former students of Walter Lincoln Palmer, Rush'21, Richard T. Crane emeritus professorof medicine, have established a fund inhis name to endow a visiting professorship in internal medicine and physiologyat the University.By the end of May, 1966, over twohundred fifty of his friends had contributed about seventy thousand dollarsto the fund, and this achievement wasmarked by a dinner held at the Centerfor Continuing Education. During the informal program, President GeorgeWells Beadle presented Dr. Palmerwith an illuminated scroll inscribed:"To Walter Lincoln Palmer with thegreatest esteem and affection, we, yourfriends, colleagues and patients, are honored to pay you tribute. Your years ofdevoted service to mankind, medicine,and The University of Chicago havebeen marked by inspiring scholarship,wisdom and perception. On this occasion,we take great pleasure in recognizingyour career of outstanding merit andpaying homage to a man we hold universally in highest regard by establishingThe Walter Lincoln Palmer Fund forfurthering internal medicine and physiology at The University of Chicago."In addition to honoring Dr. Palmer,the purpose of the dinner was to publicize the fund's establishment and to announce that the drive would continueuntil an amount sufficient to endow thevisiting professorship has been raised.RICKETTS AWARDCharles Yanofsky, professor in the department of biological sciences at Stanford University, was the 1966 recipientof the Howard Taylor Ricketts Award.The title of his award lecture was "GeneStructure and Protein Structure."Professor Yanofsky was honored forhis experimental and theoretical contributions to the fields of biochemistry andgenetics. Based on his studies of tryptophan metabolism in microorganisms, hedeveloped a useful new approach to thestudy of important biochemical and genetic phenomena. With this technique, hewas the first to demonstrate the colinearity of the genetic material and the primary structure of proteins, one of thebasic concepts of modern molecular genetics. HUMPHREYSDR. HUMPHREYS HONOREDThe medical staff and the Board ofDirectors Corporation of WoodlawnHospital have each contributed sevenhundred fifty dollars to the Eleanor M.Humphreys Loan Fund. The gifts weremade in recognition of her service toWoodlawn Hospital and her dedicationto the field of anatomical pathology.The loan fund in honor of Dr.Humphreys, Rush, '29, was establishedin 1958 when she became emeritus professor of pathology. Contributions fromher friends and former students havemade the fund one of the major sourcesof loans for medical students at the University.Dr. Humphreys was a member of thestaff of Woodlawn Hospital from 1958until last spring when she retired. Afteran adventurous month in Greece withthe Robert Wisslers, she went to livewith her nephew, Hugh, and his familyin their historic eighteenth-century houseon Staten Island. There she can watchocean-going vessels entering and leavingNew York harbor and entertain hersmall grandnieces with stories of herVermont childhood.Her address is 2 Hylan Boulevard,Staten Island, N.V. 10305.From 1955 to 1957, while on the faculty at Western Reserve University, Professor Yanofsky held a Lederle MedicalFaculty Award. In 1959 he won the EliLilly Award in bacteriology. He receivedthe U.S. Steel Award in molecular biology in 1964 and during that same yearwas elected to the American Academy ofArts and Sciences. He was named tomembership in the National Academy ofSciences in 1966. REED MAKES GIFTFOR NEW SURGERY WINGClarence C. Reed, Rush '25, of Compton, California, has pledged two milliondollars toward the construction of a newsurgery building. His gift, the largestmade by an individual in the University'Sthree-year fund raising campaign, willunderwrite almost one-quarter of theestimated nine-million-dollar cost of theproposed structure.Architectural plans, including clinicallaboratories, post-operative wards, andsurgical facilities, are nearing completionbut construction will not begin until additional funds can be raised. The building will be located on the west side ofEllis Avenue, just north of the presentsurgery wing of Billings Hospital.Before entering Rush, Dr. Reed graduated from Mount Union College inAlliance, Ohio. He served his internshipand residency at Cook County Hospitaland received additional surgical trainingat Los Angeles County Hospital. In 1932and 1933 he pursued postgraduate studiesin reconstructive surgery in Berlin, Vienna and London and has been boardcertified in plastic surgery since 1939.Dr. Reed has long been a strong supporter of the University. In 1959 heestablished the Clarence C. Reed Memorial Trust Fund to distribute incometo Mount Union College and The University of Chicago. His gift expresses hisconfidence in the aspirations of the Medical School and offers generous encouragement toward their realization.HOMECOMING DAYIn June the School of Medicine held aHomecoming Day for alumni who werein Chicago attending the A.M.A. Convention. The all-day program was planned byHilger Perry Jenkins, Rush '26.Goldblatt Conference Room was usedas a gathering place for the day-longOpen House at which many alumni tookthe opportunity to visit with their formerteachers and colleagues. Conducted toursof the Hospitals and Clinics, arranged byJohn Van Prohaska, '33, were scheduledthrough the afternoon.About eighty people attended cocktailsand dinner at the Quadrangle Club. Walter Palmer, Rush '21, was toastmasterfor the informal program. At the end ofthe evening, Dr. Jenkins showed some ofhis films from earlier alumni reunions.M E 0 I CAL A L U M NIB U L LET I N 19NEW APPOINTMENTSZUSPANFrederick P. Zuspan has been namedto succeed M. Edward Davis, Rush '22,as Joseph Bolivar De Lee Professor andchairman of the department of obstetricsand gynecology and as chief of servicesof Lying-in Hospital.Dr. Zuspan's undergraduate work atOhio State University was interrupted byservice in the Navy and Marine Corpsfrom 1942 to 1945, but he returned totake his B.A. degree in 1947 and hisM.D., cum laude, in 1951. He remainedat Ohio State University for his internship and part of his residency training.Upon completion of his residency atWestern Reserve University in 1956, hebecame chief of the division of obstetricsand gynecology at McDowell MemorialHospital. He returned to Western Reserve in 1958 for a two-year Oglebay fellowship and in 1959 was appointed assistant professor. In 1960 he was namedprofessor and chairman of the department of obstetrics and gynecology at theMedical College of Georgia, the positionhe held just prior to joining our staff.Dr. Zuspan's abilities as an administrator, his concern for teaching, and histalents as a clinician and investigatorenabled him, in the six years he was atGeorgia Medical College, to build hisdepartment into one recognized nationally as a leader among southern medicalschools. He also served as a consultantat the Milledgeville State Hospital, theMacon City Hospital, and at the University, St. Joseph's and Fort Gordon hos-20 M E Die A L A L U M NIB U L LET I N pitals in Augusta. He is a fellow of theAmerican College of Obstetricians andGynecologists, and his other professionalaffiliations include membership in theAssociation of Professors in Gynecologyand Obstetrics and the Society for Gynecologic Investigation. He was elected toADA in 1950.Dr. Zuspan is the author of more thanforty reports on clinical medicine andresearch and has been a contributing author to three medical textbooks. One ofhis chief research interests has been intoxemia of pregnancy. In a study covering a period of four years, he and hisassociates approached the disease from ametabolic standpoint. Toxemic patientswere hospitalized, sometimes for as longas six months, and complete metabolicbalance ward-studies were made. Normalpatients and toxemic patients, especiallythose with eclampsia, were compared.Through these studies, the first of theirkind, he demonstrated that toxemia ofpregnancy is a catabolic disease whichresults in malnutrition of the mother andpossibly of the baby.For the past eight years, Dr. Zuspanhas also been investigating the metabolism of epinephrine and norepinephrine,the hormones associated with stress asthey relate to the pregnant patient, andmore specifically, to the toxemic patient.In research on the response of the uterusto these drugs it has been shown thatepinephrine quiets the uterus and norepinephrine stimulates it. A metabolic bedwith a special prosthetic device for thenewborn female was developed to collecturine and determine whether or notthese hormones cross the placenta andaffect the baby. It was discovered thatcatecholamines are increased during labor and delivery. This increase affectsthe blood sugar and also a fat componentof the blood from mother and baby.Techniques, specific for each, to measurethe amount of the two hormones in bothblood and urine have been developed inhis laboratories. He will continue this research at Lying-in Hospital in order toexplore further pathways of stress during pregnancy and the effect of thesehormones upon the fetus.Dr. and Mrs. Zuspan, after surmounting the trials of remodeling an oldbrownstone on Kenwood Avenue, havesettled into the University community,and their three children are attendingthe Laboratory School. KITTLEC. Frederick Kittle, '45, has returned to the University as professorand chief of the section of thoracic andcardiovascular surgery. He graduatedfrom the medical school with honors andremained here for his internship. Aftertwo years' service in the Navy, he wentto the University of Kansas MedicalCenter for residency training. Upon completion of his residency and a master'sdegree in surgery in 1950, he was appointed instructor. In 1953 he becameassistant professor of surgery and lecturer in the history of medicine and wasmade associate professor in 1959. Heserved as consultant in surgery for theOak Ridge Institute of Nuclear Studiesfrom 1950 to 1955 and has also been aconsultant to Veterans AdministrationHospitals in the Kansas City area.Dr. Kittle is the current president ofthe Society of University Surgeons, secretary of the International Cardiovascular Society, and chairman of the surgicalprogram committee for the AmericanHeart Association. He is also serving onthe International Fellowship ReviewCommittee for the National Institutes ofHealth. His other professional affiliationsinclude The American College of Cardiology, the American College of Surgeons,the American Surgical Association, theCentral Surgical Society, the Society ofClinical Surgery, and the Society of Vascular Surgery. A member of the ADA, heheld an American Cancer Society clini-'cal fellowship from 1950 to 1952 and wasNEW APPOINTMENTSa Markle Scholar from 1953 to 1958.Dr. Kittle has published more thanseventy-five papers in the fields of pulmonary and cardiovascular surgery. Hisrecent research is concerned with changesin pulmonary vessels of the fetal lung atthe time of birth and with factors regulating blood flow. In studies involvingpulmonary blood flow of the fetal lambprior to and immediately after birth, hedemonstrated that vascular resistance isprimarily related to the oxygen contentof the air or fluid reaching the lung.Changes in the resistance do not appearto be mediated through nerve pathways,but occur locally as a result of the directaction of oxygen on lung tissue.Regulatory mechanisms of blood flow,particularly the effects of carbon dioxideand oxygen tension as they affect bloodflow in the coronary and renal arteries,are under investigation. He will continuethis research at the University and hopesthat studies now in progress will eventually help explain some of the unknownfactors that control blood flow.Dr. Kittle's involvement in the historyof medicine is a continuing one; he iscurrently working on a review of the history of cardiovascular surgery. His extensive collection of travel books writtenby physicians reflects his interest in thefields of history, literature, and medicine.In a lighter vein, he enjoys the publications and correspondence of the SherlockHolmes cult and has written a shortmonograph on the life of Sir ArthurConan Doyle.He and Mrs. Kittle live on ChicagoBeach Drive in an apartment overlookingLake Michigan. They have four children,a son and daughter in college and ayounger boy and girl attending schools inthe University area.Constantine S. Spyropoulos, an authority on electrophysiology, has beenappointed professor of physiology. A native of Greece, Professor Spyropoulos received his A.B. degree from the University of California at Berkeley in 1950and his Ph.D. in 1954 from the University of California at Los Angeles. Whilepursuing graduate studies at U.C.L.A.,he held various teaching and research fellowships. From 1954 to 1961 he was associated with the Laboratory of Neurophysiology at the National Institutes of SPYROPOULOSHealth in Bethesda. For the past fiveyears he has been co-director of the department of biophysics and cyberneticsat the University of Genoa.He is a member of the Marine Biological Laboratory in Woods Hole,Massachusetts, the American Physiological Society, the Biophysical Society, andSigma Xi.Professor Spyropoulos is the author ofmore than twenty-five research papers inthe field of neurophysiology. Much ofhis work has concentrated on the problem of nerve impulse transmission andpropagation. His investigations of thecellular physiology of the membrane ofgiant squid axon have contributed newinsights into the problem of nerve excitation. In recent experiments on thisnerve structure, he has discovered important relations between temperaturechange and the behavior of the nervemembrane toward various calcium andpotassium ions. These relations shouldultimately be of importance in understanding the molecular basis of nervecell behavior.In addition to his teaching responsibilities at the University, Professor Spyropoulos will continue research on theelectrophysiological properties of nervecell membranes. At present he is dividing his time between the Universitycampus and the Atomic Energy ResearchCenter in Athens, where his work on thesquid axon is now being conducted. Albert B. Lorincz, '46, has been appointed professor of obstetrics and gynecology. In addition to his M.D. degree,Dr. Lorincz received his bachelor's degree from the University in 1944, tookthree and a half years of his residencytraining at Lying-in, and was an assistantprofessor of obstetrics and gynecologyfrom 1958 to 1961. For the past fiveyears he has been professor and chairman of the department of obstetrics andgynecology at The Creighton University.In Omaha, he also served as director ofthe obstetrics and gynecology departments for the Creighton Memorial St.Joseph's Hospital and the ArchbishopBergan Mercy Hospital, as chief of obstetrics at Booth Memorial Hospital, andas a consulting gynecologist for otherhospitals in the city.LORINCZDr. Lorincz spent eleven years in theArmy Medical Corps and from 1951 to1958 served as head of the obstetrics andgynecology service at various militaryhospitals throughout the country. Heholds the rank of Lt. Colonel in theArmy Reserve. He is a fellow of theAmerican College of Surgeons and theAmerican College of Obstetricians andGynecologists. His other professionalaffiliations include membership in theCentral Association of Obstetricians andGynecologists, the American FertilitySociety, the International Fertility Association, the New York Academy of Sci-M E Die A L A L U M NIB U L LET I N 21NEW APPOINTMENTSences, the American Chemical Society,and the American Geriatric Society,Dr. Lorincz is involved with researchon the metabolic aspects of malignancyand reproductive physiology and haspublished over twenty papers on clinicalmanagement and research in his field.His major interest is protein biosynthesis in reproduction and malignancy inwhich he has done extensive research onfree amino acid transport and uptake inmalignancy and fetal development. Observations on the similarities betweenrapidly developing tumors and the development of the fetus led to studies onthe effects of limiting essential aminoacids in the diet of cancer patients toward inhibiting growth of malignant tumors. He found that the critical restriction of phenylalanine in patients withadvanced malignant disease could suppress active tumor growth and in certaincases achieve obvious regression of thedisease without adverse side effects onthe host. Such palliative retardation ofthe malignancy permitted, in some patients, utilization of conventional formsof cancer therapy otherwise not possible.The encouraging responses in significantnumbers of patients with far-advancedmalignant tumors may ultimately proveto be a valuable adjunct to cancer therapy.In addition to his teaching and clinicalresponsibilities at the Medical School,Dr. Lorincz will continue research onprotein biosynthesis and hopes to explorethe implications of essential amino acidcurtailment on cancer retardation.Dr. and Mrs. Lorincz have seven children ranging from preschool throughcollege age. They are en joying theirhome on Woodlawn Avenue and their return to the University community.Harry J. Lowe joined the faculty thisfall as professor of anesthesiology in thedepartment of surgery. Dr. Lowe received his B.S. and M.S. degrees inchemistry from the University of Arizona in 1943 and 1945 and his M.D. degree from Johns Hopkins in 1949. Following graduation, he remained at JohnsHopkins as an American Cancer Societyfellow doing research in enzymology. In1952 he went to the University of TexasMedical Branch as assistant professor in22 M E 0 I CAL A L U M NIB U L LET I N LOWEbiochemistry and was made associateprofessor the following year. He servedwith the Army Medical Corps from 1955to 1958 and during this time became interested in the problems of anesthesiology. He took his internship at the William Beaumont Army Hospital and, atthe end of Army service, joined the staffof the. Roswell Park Memorial Institutein Buffalo, New York. He completedresidency training at Millard FillmoreHospital in 1963 and in 1964 was namedassociate research professor of anesthesiology and director of the Hyperbaric Facility at the Millard Fillmore ResearchInstitute of the State University of NewYork in Buffalo.Dr. Lowe has published more thantwenty-five research papers, many ofthem concerning the techniques of anesthesiology. His professional. affiliationsinclude membership in the AmericanChemical Society, the American Association for the Advancement of Science,and Sigma Xi.Dr. Lowe's current research is basedupon the development of very rapidmethods for determining the concentration of anesthetics in gases, blood, andtissues. He is using these methods to investigate the rate of uptake and elimination of anesthetics under clinical conditions as well as on experimental animals.In studies on experimental animals,the rate of accumulation of anesthetics in tissue and the solubility of anestheticsin various tissues are under investigationin an effort to correlate the solubilityfactor with tissue lipid composition. Thestudies are directed at a more completeunderstanding of the uptake and distribution of anesthetics in order to developquantitative techniques for clinical application.Dr. and Mrs. Lowe are living in theSouth Shore area adjacent to the University. They have five children, threeboys and two girls. One of his chief leisure time activities is Boy Scout work.He has also developed an interest inglassblowing with particular emphasis onthe design and repair of experimentallaboratory equipment.LANGRIDGERobert Langridge, an authority onbiological uses of X-ray diffraction, hasbeen appointed professor in the department of biophysics. He was born inEssex, England and received his B.Sc.degree in 1954 and his Ph.D. in 1957from the University of London. Histhesis director was M. H. F. Wilkins,who shared the 1962 Nobel Prize inmedicine with F. H. C. Crick of Cambridge, England, and University of Chicago alumnus James Dewey Watson forresearch on the molecular structure ofDNA.NEW APPOINTMENTSProfessor Langridge held successivetwo-year research fellowships at YaleUniversity and the Massachusetts Institute of Technology from 1957 to 1961.For the past five years he has been associated with the Biological StructureLaboratory of the Children's Cancer Research Foundation in Boston. From 1963to 1966 he was also a member of thedepartment of biophysics at HarvardUniversity.Professor Langridge is the author orco-author of more than twenty researchpapers in the field of molecular biology.He has concentrated on the use of X-raydiffraction to study the structure oflarge biological molecules, particularlythe nucleic acids and viruses. At theUniversity, he will be responsible forgraduate courses in molecular biologyand will continue his research on X-raydiffraction analysis. He hopes thatstudies now in progress will add to theunderstanding of molecular genetics andprotein synthesis and will have eventualapplication to clinical medical research.He is a member of the American Society of Biological Chemists, the American Crystallographic Association, theBiophysical Society, and Sigma Xi.Last summer he served as chairman ofthe section on nucleic acids at the Congress of the International Union of Crystallography held in Moscow. He also lectured at an internationally sponsoredsummer school on molecular biology heldin Greece and presented a paper at theInternational Biophysics Congress inVienna.The Langridges and their two youngdaughters are living in the Kenwoodarea. He includes travel, mountains, andmusic among his favorite non-academicinterests.Harry A. Fozzard has been appointedassociate professor in the department ofmedicine. He attended Washington andLee University and graduated fromWashington University School of Medicine at St. Louis in 1956. After interning at Yale University School of Medicine, he served for two years as anaval medical officer. He was stationedat the U.S. Naval Medical ResearchLaboratory at Camp Le Jeune, NorthCarolina, where he evaluated the efficacy of levoarterenol in the treatment of FOZZARDirreversible hemorrhagic shock, studiedthe effects of thermal injury on hepaticfunction, and developed a radiographicmethod for determining cardiac output.He returned to Washington Universityafter naval service and completed hismedical residency in 1961. This was followed by a two-year U.S.P.H.S. fellowship in the division of cardiology atWashington University where he becameinterested in the factors controlling theexcitability of cardiac cells. From 1963to 1964 he worked with Professor SilvioWeidmann at the Physiological Instituteat the University of Bern, Switzerlandand during this period developed methodologies for defining certain electricalfeatures of cardiac cells, including thecapacitance of cardiac purkinje fibersand the changing resistance of cardiaccell membranes during depolarizationand repolarization.Between 1962 and beginning his tenurehere in 1966, he held an appointment asinstructor in medicine and then a jointappointment as assistant professor inmedicine and physiology at WashingtonUniversity. His professional affiliationsinclude membership in the BiophysicalSociety, the Central Society for ClinicalResearch, and the American Federationfor Clinical Research.Dr. Fozzard has the credentials of askilled physician and investigator and isdevoted to a goal that our medical schoolhas long emphasized, that of training andstimulating medical students to become expert physicians, teachers, and investigators. He has already become an important contributor in the extensive administrative, clinical, teaching and research activities of the section of cardiology. He has had very useful experiencein intensive cardiac care and the computerization of physiological data. Hewas instrumental in starting a cardiacintensive care unit at Barnes Hospital inSt. Louis and will make valuable contributions to the new cardiac unit reaching completion on the M-4 Nursing Division.Dr. and Mrs. Fozzard live in SouthShore Highlands and their two sons, ages6 and 10, attend the University's Laboratory School.ElAMJames O. Elam, an authority on techniques of inhalation and cardiopulmonary resuscitation, has been named professor of anesthesiology. In addition tobeing a full time staff member at Lyingin Hospital, he will serve as director ofeducation for the section of anesthesiology in the department of surgery.Dr. Elam received his A.B. degreefrom the University of Texas in 1942and his M.D. from Johns Hopkins University in 1945. From 1945 to 1951 heserved internships and residencies insurgery and anesthesiology at the Bethes-M E 0 I CAL A L U M NIB U L LET I N 23NEW APPOINTMENTSda Naval Hospital, Washington University in St. Louis, and at the Universityof Iowa. He was assistant professor ofanesthesiology at Washington Universityfrom 1951 to 1953, a position he left toorganize the department of anesthesiology at Roswell Park Memorial Institute.During the ten years he served as director of that department, he was also onthe faculty of the School of Medicine atthe University of New York at Buffalo.In 1964 he assumed the chairmanship ofthe department of anesthesiology at thenewly established University of MissouriSchool of Medicine in Kansas City, theappointment he held just prior to joiningour faculty.Dr. Elam is co-author of Fundamentals of Cardiopulmonary Resuscitationand has contributed more than eightyresearch papers and six chapters in medical texts to the literature in his field. Hehas served on the national committees ofmany professional anesthesiology socie- ties and since 1953 has been a researchcontractor for the Office of the SurgeonGeneral.His research on the regulation of respiration during anesthesia has led to thedevelopment of precise measuring devices that can determine the amount ofrespiratory assistance patients requireunder anesthesia. These allow the anesthesiologist to supply the required volume of each breath at the rate set by theanesthetized patient. The five new devices he has patented include a respiratory monitor and a volume indicator foran anesthesia machine system.Dr. Elam has pioneered in the use offilms to train students in anesthesia andresuscitation. His first film, "RescueBreathing," made with Dr. David Greeneof the University of New York at Buffalo in 1959, resulted from their interest inpopularizing mouth-to-mouth breathingfor emergency resuscitation. The filmwon the Bronze Medal for Achievement of the Educational Film Library Association at the American Film Festival thatyear. It has set a record for the numberof prints made and distributed and hasbecome the standard training film for allgroups concerned with emergency lifesaving techniques. Its success led to aseries of films for teaching various kindsof professional rescue methods. One ofthese, "Water Rescue," won the 1961award from the National Committee onFilms for Safety. Dr. Elam now spendsabout twenty per cent of his time makingfilms designed to teach various anesthesiological techniques to medical students.Dr. and Mrs. Elam are living in Jackson Highlands, a residential area justsouth of the University. Their older sonand daughter are in college and theirthree younger children attend the University's Laboratory School. For recreation, he enjoys sports activities with hisfamily, particularly badminton and tennis.CANCER SPECIALISTJOINS LYING-IN STAFFMichael Newton, Director of theAmerican College of Obstetricians andGynecologists, has been named clinicalprofessor of obstetrics and gynecology.The professional society is located inChicago, and its Board has given approval for the new director to spend aportion of his time in clinical medicineat a teaching center in the Chicago area.Dr. Newton was born in Worcestershire, England and received his B.A. degree in 1942, his M.B.B.Ch. in 1944, andhis M.A. in 1946 from Cambridge University. In 1943 he was awarded an M.D.degree at the University of Pennsylvaniaand served his internship at the Pennsylvania Hospital in Philadelphia. From1946 to 1955 he was on the staff of theUniversity of Pennsylvania School ofMedicine and from 1955 to 1966 wasprofessor and chairman of the department of obstetrics and gynecology at theUniversity of Mississippi.Dr. Newton is an authority on cancer'of the reproductive organs. He has published more than seventy-five articlesand has contributed chapters to fivemedical textbooks in his area of specialization. At Lying-in, he will work in theclinical cancer program.24 M E 0 I CAL A L U M NIB U L LET I N McCARTNEY NAMED TORYERSON PROFESSORSHIPCharles P. McCartney, '43, professorand secretary of the department of obstetrics and gynecology, has been namedto succeed H. Close Hesseltine as theMary Campau Ryerson Professor of Obstetrics and Gynecology. Dr. Hesseltinereached retirement age during the academic year.Dr. McCartney received his internship and residency training here and,with the exception of three years' warservice in the Army Medical Corps, hasbeen a member of the staff at Lying-insince graduation. He has served as secretary of the department since 1958.Dr. McCartney's appointment to thename professorship is in recognition ofhis administrative and clinical contributions to the department and for his research in the field of obstetrics andgynecology. His studies on the toxemiasof pregnancy are recognized by fellow investigators as being of primary importance in the clarification and understanding of the disease. He has published overthirty research papers and has contributed eight chapters on the toxemiasof pregnanacy to medical textbooks.Dr. McCartney is a Fellow of theAmerican Gynecological Society and nu- VERMEULEN NAMEDASSOCIATE DEANCornelius W. Vermeulen, '37, professor of urology, has been named anassociate dean of the Division of Biological Sciences. In his new position, Dr.Vermeulen will be principally concernedwith the development of the clinical departments of the Division and with curriculum planning. He will work closelywith Wright Adams, associate dean andchief of staff of the Division.Dr. Vermeulen received his internshipand residency training at the Universityand served on the faculty until 1942when he joined the Army Air Force.From 1946 to 1953 he was associate professor of surgery at the University ofIllinois. He will continue to serve ashead 'of the section of urology, the position he assumed when he returned to thefaculty in 1953, and will also continue tomaintain his clinical and research programs.merous other professional associations.He is president-elect of the ChicagoGynecological Society, president of theIllinois section of the American Collegeof Obstetricians and Gynecologists, andCouncilor of the Chicago Medical Society.DEATHS'89. Elmer J. Cole, Woodbine, Iowa, July8, 1966, age 101.'93. Edwin B. Walston, Flushing, N.Y.,July 3, 1965, age 97.'99. Delano Wilcox, Newton, Iowa, October 31,1963, age 91.'03. William A. Clark, New Wilmington,Pa., August 23, 1960, age 81.Thomas O. Cole, Phoenix, Ariz., December 5, 1964, age 86.Ernest A. Lupton, Palm Springs, Calif.,May 21, 1962, age 87.'05. Robert C. Shanklin, Frankfort, Ind.,January 29, 1965, age 84.Wallace J. Smith, Cadillac, Mich., July7, 1966, age 85.'06. Allen A. Norris, Elkhart, Ind., September 11, 1965, age 90.'07. Ernest W. Miller, Milwaukee, July4, 1966, age 85.'12. Aaron Arkin, Chicago, November 1,1966, age 78.'13. Martha Hackett, Los Angeles, December 20, 1963, age 79.Harry P. Merrill, Scottsdale, Ariz., June30, 1966, age 79.'14. Carl C. Birkelo, Birmingham, Mich.,May 30, 1965, age 77.'15. Hillier L. Baker, Chicago, May 1,1966, age 79.Paul F. Thuresson, Claremont, Calif.,February 23, 1966, age 78.'16. Jacob R. Rupp, Pontiac, Michigan,May 24, 1966, age 79.'18. Earl D. Huntington, Chicago, August 5, 1966, age 78.George G. Verbryck, Long Beach, Calif.,April 11, 1966, age 71.'19. Henry D. Coles, Chicago, October 19,1966, age 70.Clarence W. Magaret, Peoria, Ill., June19, 1966, age 74.W. Donald Nickelsen, Portland, Ore.,October 23, 1963, age 69.Carl E. Schultz, Hinsdale, Ill., July 18,1966, age 73.'20. James A. Butin, Chanute, Kan., July27, 1966, age 73.Louis E. Hanson, Costa Mesa, Calif., December 12, 1960, age 74.John D. Koucky, River Forest, Ill., August 5, 1966, age 69.'21. Harry F. Becker, Van Nuys, Calif.,June 12, 1966, age 70.E. Stafford Safarik, Los Angeles, May 26,1963, age 67.'22. James H. Cryst, Los Angeles, March17, 1966, age 70.Herbert H. Inlow, Shelbyville, Ind.,October 8, 1966, age 67.Philip A. Scott, Spirit Lake, Iowa, June14, 1966, age 70.'23. Lyle G. Craig, Pasadena, Calif., April6, 1966, age 70.'24. Everette L. Campbell, Orange, N.J.,September 28, 1966, age 67.'25. Leon J. Goodman, Macon, Ga.,April 30, 1966, age 67.Aaron Q. Johnson, Sioux City, Iowa,March 12, 1966, age 69.Vernon E. Mrazek, San Bernardino,Calif., October 2, 1965, age 65.'26. Norris J. Heckel, Chicago, May 27,1966, age 68. '27. Sue Thompson Gould, Avon Park,Fla., March 18, 1966, age 67.John A. larson, Nashville, Tenn., September 21, 1965, age 72.Chester A. Perrodin, Van Nuys, Calif.,July 3, 1966, age 65.'28. James S. Beck, Tuscaloosa, Ala., September 9, 1966, age 66.Donald J. Grubb, Alexandria, La., August 29, 1966, age 71.'29. Philip Preiser, Charleston, W.Va.,November 3, 1966, age 64.Merle E. Sweeley, Inglewood, Calif.,February 16, 1966, age 63.'30. Beatrice O. Jones, Racine, Wis., May17,1966, age 68.'31. George R. Crisler, Winter Park, Fla.,September 26, 1966, age 64.Victor M. Leffingwell, Sharpsville, Pa.,April 29, 1966, age 69.'32. Louis E. Barron, Lynn, Mass., Feb-ruary 22, 1965, age 59. ,'33. George C. Coe, Chicago, July 21,1966, age 59.Harry R. Stimson, Gary, Ind., July 1,1963, age 61.Florance L. Sullivan, Freeport, Ill., August 7, 1966, age 63.'34. Benjamin Goldman, Hazlehurst,Ga., June 5, 1966, age 58.'35. Hinman A. Harris, University City,Mo., November 19, 1966, age 61.'36. Laurence M. Marsh, Rockford, Ill.,June 12, 1966, age 58.John A. Norton, Eldridge, Calif., May20, 1966, age 56.Israel H. Spector, Chicago, April 25,1966, age 58.'37. John E. Bohan, Alexis, Ill., August31, 1966, age 54.'39. James F. Donnelly, Raleigh, N.C.,June 24, 1966, age 52.William J. Hawkins, Altadena, Calif.,June 7, 1966, age 56.'40. Donald E. Nelson, Safford, Ariz.,May 30, 1966, age 55.'42. Reon H. Sanders, Wisconsin Rapids,Wis., January 28, 1966, age 60.'46. Harold S. Orwoll, Sunnyvale, Calif.,February 2, 1966, age 51.'49. Clara Lowell Levine, Hayward,Calif., April 27, 1963, age 37.FACULTYHazel Lamb Barger (Resident, '27),Phoenix, Ariz., March 12, 1966, age 65.Fremont Ellis Kelsey ('40-'51) pharmacology, Bethesda, Md., November 15, 1966,age 54.Harold A. Lockhart (Resident, '32-'33),Cedar Rapids, Iowa, November 26, 1965,age 61.John Forbes Perkins, Jr., Chicago, professor of physiology, August 7, 1966, age 57.Alvin F. Restarski (Resident, '38-'39),Chicago, July 29, 1965, age 54.Norman Roome (Resident '30-'34),Toronto, Canada, April 18, 1966, age 60.Charles Henry Swift, Rush, '10, Chicago, emeritus associate professor of anatomy, November 17, 1966, age 85.H. Fielding Wilkinson ('27-'29), otolaryngology, San Gabriel, Calif., September12, 1966, age 70. CANCER SYMPOSIUMOn October 10 and 11, The Universityof Chicago was host to two hundred cancer research scientists at The International Symposium on Endogenous Factors Influencing Host-Tumor Balance.The symposium was sponsored by theArgonne Cancer Research Hospital andheld at the Center for Continuing Education.The twenty speakers who participatedin the program discussed the three knownmechanisms for controlling tumorgrowth: the hormone system of the body,the immunity system of the host, and thebody's blood clotting mechanism.President George Wells Beadle addressed the opening session and CharlesHuggins was the speaker at the symposium banquet. The program was arrangedby Robert W. Wissler, '49, who said thiswas probably the first occasion at whichinvestigators in the three major areas ofresearch on host-tumor balance have hadan opportunity to discuss and comparetheir work.Papers were presented by scientistsfrom England, France, Hungary, Ireland,Scotland, Sweden, Switzerland, as well asThe University of Chicago and otherleading institutions in the United States.NEW BIOGRAPHY OFDR. BILLINGSA biography of Frank Billings, written by Edwin F. Hirsch, Rush '16, waspublished by The University of ChicagoPrinting Department in November. Dr.Billings was actively involved in thegrowth and development of medical education at the University and at otherteaching institutions in the city. Dr.Hirsch, in dealing with this period of hissubject'S life, relates the background ofearly medicine in Chicago.Distribution of the book is beinghandled by the Chicago Medical Society.Dr. Hirsch plans to contribute profitsfrom the sale of the book to the University's Medical Students' ScholarshipFund.Louise Holland Coggeshall. Friends ofthe Lowell T. Coggeshalls were saddened tohear of the death of Mrs. Coggeshall inFoley, Alabama, on July 17, 1966. She was62 years of age. Dr. Coggeshall, a Trusteeof the University, retired as vice presidentin June, 1966. He was Dean of the Divisionof the Biological Sciences from 1947 to 1960.M E 0 I CAL A L U M NIB U L LET I N 25� F_A__C_U_L_T_Y_N__E_W_S �II R_E_S_'D_E_N__T_N_E_W__S__William E. Adams was recently electeda member of the Board of Directors of theAmerican Cancer Society and Treasurer ofthe International Congress on Smoking andHealth. In June, he was named presidentelect of the American College of ChestPhysicians.Dr. Adams and Peter V. Moulder, Jr.,'45, participated -in the International Congress of the American College of ChestPhysicians in Copenhagen in August. Theyalso took part in a series of medical meetings in Stockholm, Helsinki, Leningrad,Moscow, Warsaw, and Prague.A lecture entitled "Around the Heart inForty Years" was presented on November 2,in honor of Emmet B. Bay, Rush, '22, professor of medicine, by Louis Leiter, Rush,'21. Dr. Leiter, who served on our facultyfrom 1923-1925 and 1926-1942, is chief ofthe division of medicine at Montefiore Hospital and professor of medicine at ColumbiaUniversity in New York. On October 15, overone hundred colleagues and former studentsattended a dinner at the Quadrangle Club tomark the occasion of Dr. Bay's retirementfrom active teaching duties. Dr. Bay willcontinue to work at the Hospitals, in theStudent Health Service.George N. Catravas ('54-'63) has joinedthe Armed Forces Radiobiology ResearchInstitute in Bethesda, Maryland. He was aNational Academy of Sciences Fellow inthe department of biochemistry from 1954to 1956 and served on the faculty until 1963.Since 1963 he has been head of biochemicalresearch for Technicon Corporation inChauncey, New York.Lowell T. Coggeshall presented thefourth annual Michael M. Davis Lecture oncampus in May. He spoke on "Progress andParadox on the Medical Scene."Ivan Diamond, '63, was awarded theJoseph A. Capps Prize for Medical Researchby the Institute of Medicine of Chicago. Dr.Diamond, who completed his residency inneurology in 1965, presented his researchin a paper entitled: "Bilirubin Encephalopathy: Experimental Models in Newborn andAdult Animals."C. Wesley Eisele ('34-'51) has beennamed an Honorary Fellow in the AmericanCollege of Hospital Administrators.Richard H. Evans, '59, left the Hospitalsin June to enter the U.S. Air Force. He holdsthe rank of Captain and is chief of thoracicsurgery in the Tachikawa Hospital in Japan.Marcel Frenkel, '58, assistant professorof ophthalmology, left the University inNovember to enter private practice. He willalso be assistant professor at the University of Illinois School of Medicine and onthe staff of the Illinois Eye and Ear Infirmary.H. Close Hesseltine ('31-'66), MaryCampau Ryerson professor emeritus, has entered private practice of obstetrics andgynecology in Chicago.In June, Charles Huggins received theRamon Guiteras Award of the AmericanUrological Association in Chicago and inthe same month was presented the GoldMedal in Therapeutics by the WorshipfulSociety of Apothecaries of London. The26 M E 0 I CAL A L U M NIB U L LET I N medal was given "in recognition of his greateminence in the fields of physiological surgery and therapeutics." Previous winners ofthe Medal include Sir Frederick Grant Banting, who first isolated insulin, and SirAlexander Fleming, the discoverer of penicillin. In November, Dr. Huggins was one ofthe seven recipients of the Gairdner Awardsfor medical research. The awards, sometimesregarded as Canada's Nobel Prizes, wereinitiated in 1957 by J. A. Gairdner, a Toronto financier and industrialist, to rewardmedical scientists for their contributions tohumanity. Dr. and Mrs. Huggins attendedthe presentation dinner in Toronto and Dr.Huggins gave an informal paper on hormonetreatment of prostate cancer before theToronto Academy of Medicine.Leon O. Jacobson, '39, has been awardedan honorary degree from North DakotaState University, the school at which he didhis undergraduate work. Dean Jacobson,The University of Chicago Hospitals andClinics and the School of Medicine werethe cover story for the September 12 issueof Modern Medicine.In December, Dr. and Mrs. Jacobsonwere guests at the Nobel Awards ceremonyin Stockholm.Fred Katz ('63-'66), assistant professorof medicine, has been appointed head of theendocrinology section of the department ofmedicine at Loyola University's StritchSchool of Medicine.Lawrence H. Lanzl of Argonne CancerResearch Hospital has been appointed byGovernor Kerner to a three-year membership on the Radiation Protection AdvisoryCouncil in the Department of Public Health.Clifford S. Melnyk, instructor in medicine, has been named the first Alvin Handmacher Fellow in gastroenterology. The fellowship was established at the University in1965 by a bequest from the late Alvin T.Handmacher. It will be awarded annuallyfor four years to outstanding candidates inthe field of gastroenterology who have completed their medical residencies and postdoctoral training and who are preparing forcareers in academic medicine. Dr. Melnykwill complete his third year in the trainingprogram of the gastroenterology section inJune and has accepted an appointment asassistant professor of medicine at the University of Oregon.Gerald Mendel ('54-'66), assistant professor of medicine, has entered private practice in Evanston. He will also be assistantprofessor of medicine at Northwestern University and on the staff of Evanston Hospital. Dr. Mendel received his internship andresidency training in the Hospitals.Frank W. Newell, head of the section ofophthalmology, gave the Fiftieth AnnualMontgomery Lecture at Trinity College inDublin in April and in May addressed theSeventieth Annual Japanese Congress ofOphthalmology at Tottori University inJapan. In November he was honored as the1966 recipient of Loyola University's StritchAward. Dr. Newell received his M.D. degree from Loyola in 1939.Robert G. Page, associate dean of thedivision, left in early November on a fiveweek fact-finding tour of medical schools in Willard A. Fry ('59-'66), instructor andchief resident, has joined the department ofsurgery at Northwestern University with therank of associate. He is also a consultantat Suburban Cook County TuberculosisSanitarium and a member of the staff atEvanston Hospital.The Medical Alumni Association sponsored a piano recital by David Gross, '64,resident in urology, in November. He playedworks of Bach, Beethoven, and Brahms before a capacity audience in the Law SchoolAuditorium. Before entering medical school,Dr. Gross studied at the Cleveland Instituteof Music and with Rudolf Serkin. This washis fourth appearance on campus. In 1960he and his father, also a physician, gave apiano and violin recital; in 1961 he performed with The University of Chicago Orchestra; and in 1964 he presented a Beethoven recital.Peter Lazarovitz won first prize in theresidents' competition of the ChicagoRoentgen Society. This is the third consecutive year that a resident from the University's radiology department has beenawarded first prize.Jafar Shah Mirany ('61-'66), instructor and senior resident, has joined the surgical staff of Marquette University in Milwaukee.Kenneth W. Teich ('65-'66), a fellow inthe department of pyschiatry, has been appointed director of medical education at St.Joseph Mercy Hospital in Pontiac, Michigan.The University of Chicago has received afive-year grant from the National Institutesof Health to increase research training foryoung teaching surgeons. In announcing thegrant, Rene Men guy, professor and chairman of the department of surgery, pointedout that it would make possible more intensive training for some surgical residentsplanning careers in academic surgery. Theywill be able to take two to three years' additional course work and laboratory trainingin the basic sciences most closely allied withtheir specialty. Three residents will enterthe program each year until a total of fifteenare enrolled.Asia. He attended the Third World Conference on Medical Education in New Delhiand visited medical schools in Lebanon,Afghanistan, Thailand, Malaysia, Hawaiiand several other countries. His study wassupported by a grant from the RockefellerFoundation.James J. Rams ('55-'66), assistant professor of surgery, has accepted the appointment of assistant chief surgeon at the Veterans Hospital in Lexington, Kentucky. Hewill also be on the surgical faculty at theUniversity of Kentucky medical school.Rudi Schmid ('62-'66) has joined theUniversity of California in San Franciscowhere he will be professor of medicine andsection chief of the division of gastroenterology. Dr. Schmid was professor ofmedicine and director of the Chronic Disease Research Laboratories.GRADUATE NEWS'39. Lauren M. Neher, of Jerome, Idaho,served recently with Project Viet Nam. Doctors in the project serve without pay inprovincial hospitals in various sections ofViet Nam, administering to sick andwounded civilians. Dr. Neher is currentlychief of staff at St. Benedict's hospital inJerome.'40. Horace M. Gezon became director ofpediatric services of the department ofhealth and hospitals, and professor andchairman of the department of pediatrics atthe Boston University School of Medicinein September. In his new position he willalso be chief of pediatrics for Boston CityHospital. Dr. Gezon took his internship andresidency training here and served on thefaculty until 1952. Since leaving the University he has been on the staff of the University of Pittsburgh's School of Medicine.'42. Kirsten Vennesland left the FirlandSanitorium in Seattle to accept a position atthe Lanakila Health Center in Honolulu,operated by the Public Health Service ofHawaii.'43. Maxwell A. Johnson has beennamed president-elect of the Oklahoma StateMedical Association, to serve for 1967-68.Dr. Johnson has been in the practice ofurology in Tulsa since 1948.Merton F. Wilson was a visitor in theHospitals and the Alumni office this summer. He is an associate clinical professor ofgeneral surgery at the University of Cincinnati.'44. Lt. Col. Jack R. Farber recently completed an eight-week course of specialized study at the School of Aerospace Medicineat Brooks Air Force Base, Texas.David T. Hellyer, who has been in private practice in Tacoma, Washington forthe past twenty years, recently publishedYour Child and You: A Pediatrician Talksto New M others with a preface by F. Howell Wright (Delacorte Books).Melvin Newman, chairman of the department of surgery at the National JewishHospital in Denver, was recently electedchief of staff.'46. Nels Strandjord will leave in December for Viet Nam. Under the sponsorship of the State Department, he will lecture for two months at the medical schoolin Saigon.'47. Robert M. Chanock was named the1966 receipient of the Kimble MethodologyAward for work that led to the identification of a mycoplasma, known as Eatonagent, as one of the major causes of pneumonia in man. Dr. Chanock is chief of therespiratory virus unit with the Laboratoryof Infectious Diseases for the National Institutes of Health.Robert Shuler, from Sitka, Alaska, hasbeen elected president of the Alaska StateMedical Society. He attended the two-daymeeting of the Organization of the Association of Medical Society Presidents heldin Chicago in August.'49. Ernest C. Siegfried has been appointed medical director of the Federal Bureau of Prisons with the rank of AssistantSurgeon General. The Federal prison program is administered jointly by the Depart- ment of Justice and the Public Health Service. Dr. Siegfried has been with theU.S.P.H.S. since graduation, with appointments at Staten Island, Boston, Seattle, andmost recently as Indian Health Area Director in Phoenix, Arizona.'50. Mary Jean Gatewood Kohn andMartin Kohn of Burlingame, Californiacompleted a voluntary two-month servicein Nicaragua on the S. S. HOPE in July.They previously served with HOPE on aPeruvian voyage, and Martin was on theship's 1960 maiden voyage to Indonesia andSouth Viet Nam. Dr. Kohn is a clinical instructor in internal medicine at StanfordUniversity and his wife is a pediatrician.'54. Daniel Levinson was a visitor in theHospitals in June. He is an assistant professor of medicine and psychiatry at theUniversity of Rochester.'57. Shamay Cotev is on leave of absence from the department of anesthesiologyat Hadassah University Hospital in Jerusalem to take a year's research fellowship inthe Cardiology Research Institute at theUniversity of California in San Francisco.'60. Norman Rozansky, Lt. Commanderin the Naval Reserve at Bethesda NavalHospital, recently became a diplomate of theAmerican Board of Ophthalmology.'62. Pat O. Daily has completed his armyservice and is in residency training in surgery at Stanford University.'M. Captain Gary Hoffman completedhis internship at Lackland Air Force Baseand is a flight surgeon at the Bien Hoa AirForce Base in Viet Nam.RUSH NEWS'96. Frederick M. Rossiter of Paradise,California wrote recently that he seldomsees news of Rush graduates earlier than1908. He says he is in good health and wouldenjoy hearing from alumni of his generation.'19. Hedwig Stieglitz Kuhn from Hammond, Indiana, who has been in the practiceof ophthalmology for the last thirty years,and her son, Arthur J., an otolaryngologist,have joined the Hammond Clinic, a groupof some thirty-five doctors in various specialties and general practice. Dr. Kuhn wrotethat the organization is working on plansfor its own hospital and research center.'25. Frederick P. Purdum retired afterthirty-nine years of practice in East Brady,Pennsylvania. The occasion was marked bya testimonial dinner attended by over fourhundred of his friends and patients. Thecommunity honored him by renaming thestreet on which he lives, Purdum Street.'26. Alexander Brunschwig (Fac. '28-'47) was recently awarded the degree ofDoctoris Honoris Causa by the Universityof Bordeaux, France. '29. Leonidas H. Berry was one of fourteen alumni honored by the University ofChicago Alumni Association at its annualAwards Assembly. The Alumni Citations aregiven in recognition of creative citizenshipand exemplary civic and social leadership.'32. In June, Catherine L. Dobson attended the International Infertility Meetingin Sweden before travelling to Tunis whereshe had volunteered for a month's servicewith CARE-MEDICO.Louis B. Newman was recently honoredas the recipient of the first DistinguishedAchievement Award from the Associationfor Physical and Mental Rehabilitation inChicago.'38. Arthur Robinson has been promotedto professor of biophysics and pediatrics atthe University of Colorado School of Medicine. He has been a member of the pediatricsfaculty there since 1948 and has held a jointappointment in the biophysics departmentsince 1964.'39. Robert F. Rushmer, professor ofphysiology at the University of Washington School of Medicine, delivered the annualNathanson Memorial Lecture at the University of Southern California. He spoke on"Origins and Significance of Heart Soundsand Murmurs."'40. Henry S. Kaplan, professor and headof the department of radiology at StanfordUniversity School of Medicine, was awardedthe French Legion of Honor in recognitionof his "exceptional contribution to the development of Franco-American scientificrelations and in esteem for his remarkablescientific work." Dr. Kaplan has been working on the high-energy radiation treatmentof cancer and was one of the principal figures in the design and use of Stanford'slinear accelerator cancer gun.'41. Matthew Kobak received an HonorsAchievement Award from The AngiologyResearch Foundation and the Purdue Frederick Company in recognition of a significantcontribution to the literature of vascularmedicine and surgery. Dr. Kobak was citedfor his research paper: "Etiological Factorsin Venous Thrombosis of the Legs."PICTURE CREDITSArchie Lieberman-cover, pp. 3,14 (Kennedy and Hogness), pp.15, 16 (Hopkins and Hekmatpanah), pp. 17, 19, 21 (Lorincz), pp. 22, 23(Elam) ; Joan Hill-p. 20 (Zuspan), p. 23 (Fozzard) ; Jon Pownall-po 4; Joel Snyder-p.14 (Lieberman), p.16 (Kenyon and Palmer) ;Edward Campbell-p. 5.MEDICAL ALUMNI BULLETIN 27PROFILE OF THE MEDICAL CLASS OF 1969On Wednesday, September 29, 1965,there assembled on our campus theseventy-two members of the enteringmedical class. They came from theirhomes in twenty different states, Washington, D.C., Argentina and the Netherlands. Twenty of· the students werefrom Illinois and twelve more camefrom other midwestern states. The following table gives general informationregarding the selection of the class of1969:Total number of applicants .Total number in entering class .Number of foreign students .Total number of men .Single .Married .Married with children .(one child each)Total number of women .Single .Married .Married with children . 12257226352929720All seventy-two students in the entering class, including the two foreignstudents, received their undergraduateeducation in the following forty-sixAmerican colleges and universities.Antioch .c., OhioBrooklyn C.U. of California, BerkeleyCalifornia Institute of TechnologyCarleton C., Minn. (2)Carroll C., Mont.Catholic U., Washington, D.C.U. of Chicago (6)U. of CincinnatiCity C. of New YorkColumbia U.U. of ConnecticutThe Cooper Union, N.Y.Duquesne U.Earlham C.Harvard U. (6)U. of HawaiiU. of Illinois (3)Indiana U. (3)Johns Hopkins U.Knox C., IllinoisLafayette C., Pa.Lawrence C., Wis.Loyola U., Chicago (2)Massachusetts Institute ofTechnology (2)U. of Michigan (5)Michigan State U.Monmouth C., Ill.North Central C., Ill.U. of Notre Dame (2)Occidental C., Calif.Ohio State U.Otterbein C., OhioPembroke C., (Brown U.), R.I.U. of Pennsylvania (3)Princeton U. (2)Radcliffe C.Rutgers U.St. Louis U.28 M E 0 I CAL A l U M NIB U L LET I N St. Mary's C., Minn.Stanford U. (2)Trinity C., Conn.Vanderbilt U.U. of WisconsinU. of WyomingYaleU.The average age of the entering classwas between twenty-one and twenty-twoyears, with sixty-four members of thegroup being no more than twenty-twoyears old. The age range for this classwas a rather narrow one. The youngeststudent had just turned twenty years ofage when he began his medical studies,whereas the oldest entering student wasa Peace Corps graduate, twenty-fiveyears of age, who incidentally became athird generation University of Chicagostudent as she began her medical studies.As in previous years the Committee onAdmissions considered seriously each applicant's non-scholastic attributes in addition to his scholastic achievements andpotential. Nevertheless, of the seventytwo entering students, none had a college grade average below B - and fiftyseven possessed grade averages of B+or better. The composite college gradeaverage of the class was B+, and thirtyeight of the class members were graduated from college with honors, whilenine were elected to Phi Beta Kappa.Sixty-five members of the class hadearned bachelor's degrees in some college or university. Six of these alsoearned either an M.A. or M.S. degreeand one earned his Ph.D. degree inchemistry before entering medical school.The other seven class members had fulfilled their premedical requirements inthree years' time without receivingbachelor's degrees. On the Medical College Admissions Test, which is requiredof all medical applicants, the enteringfreshman medical class as a group scoredhigh above the national average, andindeed, even higher than last year's entering class, which previously had thedistinction of having the highest scoresof any entering medical class at theUniversity of Chicago since the inceptionof the examination over fifteen years ago.On the basis of their performance onthe MCAT, the entering freshmen wereeasily in the top 10 per cent of allmedical applicants in the country lastyear.Since each applicant is considered onhis own merits by the Committee on Admissions, it is not surprising to learn that the family backgrounds of theentering medical students are most variedand interesting. Eight come from alumnifamilies, and in three of these instancesboth parents are University of Chicagoalumni. However, only one of the alumniparents is a medical school graduate,another parent received a master's degree, and the remaining nine attendedour undergraduate college.Ten members of the elass of 1969come from homes where one or bothparents have had less than a high schooleducation. At the other academic extreme, forty-two of the students comefrom families where one or both parentsare college graduates.As might also be expected, the occupations of the fathers of the enteringfreshmen represent a general cross section of the professions, industry andlabor. Included in the group are sevendoctors, six lawyers, six engineers, fourschool teachers, three ministers, twodentists, and a school superintendent,in addition to a wide variety of businessmen, merchants, office workers, andskilled and semi-skilled laborers. Similarly, twenty-nine of the mothers havecareers in addition to that of housewifeand mother. Eleven are school teachers,nine are office workers, and two are dressmakers. The remainder include a bookkeeper, a social worker, a laboratorytechnician, a librarian, a realtor, atheatrical costumer and an engineer.The class of 1969 has now completedits first year of medical studies. By itsperformance it has proved its right tostand beside its predecessors.JOSEPH CEITHAMLDean of StudentsBULLETIN Iof the Alumni AssociationThe University of ChicagoSCHOOL OF MEDICINEDIVISION OF BIOLOGICAL SCIENCES950 East 59th Street Chicago, Illinois 60637VOL. 22 AUTUMN 1966 No.1EDITORIAL BOARDJESSIE BURNS MACLEAN, SecretaryALICE ASHIN, Editorial AssociateARCHIE LIEBERMAN, Art EditorWRIGHT ADAMS HUBERTA LIVINGSTONELOUIS COHEN PETER V. MOULDERROBERT]. HASTERLIK WALTER L. PALMERSIDNEY SCHULMAN