MODERN VERSION OF THEHIPPOCRATIC OATH(World Medical Association,First Assembly, 1947, Paris)"Now being admitted to the profession of medicine,I solemnly pledge to consecrate my lifeto the service of humanity.I will give respect and gratitude to mydeserving teachers.I will practice medicine with conscienceand dignity.The health and life of my patient willbe my first consideration."I will maintain the honor and thenoble traditions of the medical profes-.SloneMy colleagues will be as my brothers.I will not permit consideration of race,religion, nationality, party politics, orsocial standing to intervene between.my duty and my patient.I will maintain the utmost respect forhuman life from the time of its conception.Even under threat, I will not use myknowledge contrary to the laws ofhumanity."These promises I make freely andupon my honor."The Hippocratic Oath is not partof the degree-granting ceremony forM.D.'s at the University of Chicago,but this year we enjoyed the novelty ofwitnessing the administration of theOath at the Reunion Banquet. The classchose Nels Srrandjord, '46 to conductthe ceremony and the picture we tookof the short and solemn occasion furnishes the cover for this edition of theBulletin.This is the 1963 graduation and reunion Bulletin. Pictures and curriculavitae of the class of 1963 begin on page10 and are followed by abstracts of thesixteen excellent papers presented at theSenior Scientific Session of June 4.Honors and awards won by membersof the graduating class are part of theReunion story beginning on page 20.Frances Oldham Kelsey, Ph.D., '38,M.D., '50, was the 1963 recipient of theGold Key Award. A report on herBanquet speech, an account of thepresentation of the Distinguished ServiceNOTES AND COMMENTSAwards to four alumni, and other storieson the Reunion appear on pages 20-23.Lillian Eichelberger, emeritus professor since 1962, has written an articlefor us on some of her work on humanarticular cartilage-page 5. Dr. Eichelberger studied under Julius Stieglitzfor her Ph. D. in chemistry, 1921, andafter the opening of The Clinics returned to the University to work with BairdHastings in the Lasker Foundation inthe department of medicine. In 1950she joined the surgery faculty in orthopedics and became professor of biochemistry and surgery in 1958.Her working day still starts about6 :30 A.M., and if you wonder what goeson in that beehive on 0-5 ask WayneAkeson, '53, Tom Brower, JimDougherty, Jim Miles, '45, PeterMoulder, '45, or Jim Rams.George F. Dick was a favorite colleague of hers and she treasures, farbeyond its literary merit, this littlepoem he wrote for her:THE DANCE OF THE IONS The next two Bulletins will be devoted mainly to the two major projectsthe Association sponsored in the autumnquarter. The Medical Alumni Day program in October consisted of ten paperson new advances in the life sciencespresented by members of our faculty.The transcripts of the program are beingedited and will be ready soon.In early November we held what hascome to be our annual BiomedicalCareer Conference for high schoolstudents. Enough photographers wererecruited, from students to internationally known professionals, to cover the entire conference and we areeager to show you the results of theirefforts.In addition we'll tell you about newappointments; Dean Ceithaml will report on the loan funds and the newfreshman class; and we hope to havea statement from Dean Bennett.J,B.M.The ionic ballWas held in a hallWhich was really a sort of a maze,With collagen laceOn a cellular baseThey danced in an intercellular space.A chlorine (CI they say)Danced 'round with an ion named KOutside a cellThis chlorine CIIn spite of quite some odiumDisgracefully flirted with sodium,She received quite a blowWhen H two and 0Ceased their wild syncopation By dissociationThe pH became tartAs they danced off apart.For the H seized CIAnd began to raise hellThe pH became lowWith the acid you knowAnd this acidosisAffected osmosisAs each Ii ttle cellContinued to swell;Instead of decorum and quietIntercellular spacesBecame just disgracesAnd the ball went into a riot.MEDICAL ALUMNI BULLETIN 3�ttphtn Rothman1891'1963Presented by ALLAN T. KENYON, Professor of Medicine, at the Memorial Service in Joseph Bond Chapel,December 5, 1963.And so Stephen Rothman, philosopher and physician,scientist and friend, the long privilege of knowingyou has not been closed. We return to you this afternoon and will many times again. You earned manyhonors and of these we are very proud. Your facultyfamily thinks now as well of your gifts to the day byday. Because routine was always enlivened, because witalways illumined, because laughter served to blow awaythe absurd that entangles us, because scholarship waslight-footed and teaching an adventure all its own.Because conversation was, indeed, "the sport of cultivated minds." And because learning moved in and outof everyday affairs, a light here on an event passingby, a shadow growing less obscuring or moving off.For learning in medicine is rarely a noonday glare. Itis often a "sometime thing," partial and incompleteand even evanescent. Its light moves against the darkness gently as the physician moves with care. And whereit fails, wisdom must assess this compounding of lightand shade to give knowledge and ignorance each itsproper due. Such wisdom was yours, and such youshared with us. From Franz Joseph's Empire you brought a styleand a sense of elegance leaving somewhere in the discard the agony of the fall and of the aftermath. Inyour childhood the mills of Budapest ground thepeasants' grain. Your friend Bartok was even thenstriving to extract and transmute the native music. Inyour childhood and early manhood the .rise of Europeanchemistry provided a chance for the curious to seewhat it could mean to the exacting morphologist ofthe day and to the physician intent on maladies of theskin. To combine such chemical and morphological affairs is a profession indeed, and this you made yourown. To combine such concern with a grasp of musicand attention to all the beautiful things about-is alife indeed, an orchestration of diverse themes workedover until at last they seem to belong together. Andsuch you brought to us and shared with us.And so wise spirit, profound, kind and gay, youreside with us still. A monumental volume of yourwork is here for all who come. Our corridors are yours.The lives you touched are yours. Your family of thefaculty join with Irene and Stephen and Frank andall of theirs in the prayer of your adopted country, theprayer of Thanksgiving, in gratitude that we have hadand still have so much.Stephen Rothman was born on September 10, 1894, in Budapest. Afteradvanced study in physiology and biochemistry, he graduated in medicine in1917 from the University of Budapest.After a year in the Austro-Hungarianarmy, he returned to the University ofBudapest as assistant in the Departmentof Physiology. There he met andmarried Miss Irene Manheim, a youngmedical school graduate, and began hisclinical dermatologic career.In 1920 he joined the Universityof Giessen in Germany; in 1928 he returned again to Budapest to head adermatologic out-patient clinic in theHungarian government's Institute forSocial Medicine. When the Ninth International Congress of Dermatology was4 MEDICAL ALUMNI BULLETIN held in 1935 in Budapest, Dr. Rothmanwas general secretary. In 1938 heemigrated with his family to the UnitedStates and joined the University ofChicago faculty.His work resulted in more than220 scientific publications, includinghis monumental book, Physiology andBiochemistry of the Skin, published in1954. His teaching inspired someof the country's most brilliant medicalmen. The awards he received include the two highest American honorsin the field of dermatology-honorarymembership in the American Dermatological Association and the gold medalaward of the American Academy ofDermatology.A BIOCHEMICAL STUDY OF HUMAN ARTICULAR CARTILAGE DURINGTHE AGING PROCESSLILLIAN EICHELBERGERProfessor Emeritus, Departments of Biochemistry and Surgery (Orthopedics)The major changes brought about bythe process of degeneration of humanjoints occur in the articular cartilage.However, no distinction has been adequately made between this degenerativeprocess and the normal aging process.Degenerative changes have been studiedhistologically, as recent articles show,but not histochemically. Our presentstudy is an attempt to record the histochemical changes, if any, which occurwithin normal human cartilage as a result of age. This is the first step of along-range study directed at the determination of changes resulting from disease and degeneration in this humantissue.Obtaining normal human articularcartilage proved to be difficult. Tissueobtained at autopsy could not be usedbecause of the electrolyte shifts thattake place during and following death.We therefore found it necessary to usecartilage from surgical specimens. Moreover, since it was necessary to rely uponcartilage removed from joints whichwere not the seat of symptoms of disease or degeneration, our major sourcewas amputation specimens. For example,if the amputation had been performedto remove a malignancy involving theproximal femur, then the articular surfaces of the knee and foot might be normal. However, even in these instancesthe patient might have had prolongeddisability as a result of sarcoma, inwhich case the cartilage would have evidence of atrophy and could not be considered normal. Tissue was also rejectedwhen significant degenerative arthritis ordisease was demonstrated roentgenographically, microscopically, or on grossexamination of the cartilage of the joint.Thus many factors were considered be-6 MEDICAL ALUMNI BULLETIN fore the cartilage was accepted as normal, and such decisions had to be madewith uniformity. They were thereforemade each time by the same person,James S. Miles, who began this workwith me here and continued it at theUniversity of Colorado. I am indebtedto him for much data and many decisions.The specimens finally considered wereanalyzed for determination of theamounts of water, chloride, sodium, potassium, total nitrogen, collagen nitrogen and sulphates they contained. Theyare arranged by chronologie age at thetime of surgery and are placed into fourgroups as follows: group I, 10-20 yearsof age; group II, 21-51 years of age;group III 55-80 years of age, and groupIV, 81-87 years of age. Throughout thisstudy we will use the same symbols andthe same methods of calculation set upin our previous cartilage researches. Theoriginal chemical data were utilized fora number of deductions which characterize the compartments of cartilage.The same types of deductions have beenmade in former researches on normaland atrophied dog cartilage, in collaboration with Wayne H. Akeson, and on human cartilage of patients with residualpoliomyelitis, in collaboration withJames S. Miles.From a histologic standpoint, thehighly organized tissue, cartilage, maybe divided into a cellular phase andan extracellular phase. The cellularphase would include the chondrocytesthemselves with contained proteins,enzymes, metabolites, electrolytes andwater. The extracellular phase wouldinclude the fluid phase and a solidphase; the fluid phase consisting of metabolites, electrolytes, and water in transit to and from the cells; the solidphase consisting Of connective tissuefibers and the chondroitin sulphate complex. The connective tissue fibers maybe said for practical purposes to consistmainly of collagen (a protein or a mixture of proteins) with the mucopolysaccharide of cartilage as a non-collagenouschondroitin sulphate complex rather thananother gel. Thus the extracellular phaseof cartilage consists of three sub-phases:a) connective tissue phase, containingthe fiber solids and some extracellularfluid; b) chondroitin sulphate phase;and c) plasma ultrafiltrate in the interstices. The tissue fluid and the groundDATA FOR 100 Gm. ARTICULAR CARTILAGE SOUDS8 ...100908070 IBID· FIBER SOLIOS (FloD·(cSA),�. CELL SOLIDS (C),40FroURE 1substance are considered to be interconnected throughout.As Baird Hastings has said about ourwork: "This is the world of the relativemass and ionic composition of the mainphases of man in which we have livedfor thirty-five years and had excitingadventures."In order to examine these variousphases and compartments in cartilage itwas necessary to rely upon certain deductions. We have accepted the view ofThomas Brower that the chondrocytesare free of chloride. We have consideredthat the connective tissue phase is liketendon. As Jeanne Manery, I. Danielson and Baird Hastings postulated formuscle, we have assumed that the connective tissue of cartilage resembles tendon in its water, solids and electrolyteconcentrations. As a result, the connective tissue phase solids were estimatedfrom the collagen nitrogen determinations and the water and salt associatedwith these calculated. The remainingchloride in the cartilage gave a measureof the plasma ultra-filtrate volume.Thus, the salts and water in the ultrafiltrate volume and the salts and waterassociated with the tendon-like connective tissue were then subtracted from thetotal determined amounts. This remainder was assigned to the intracellularphase (chondrocytes.).Since it was found difficult to interpretthe data from single patients of differentages it became evident that there wouldbe an advantage in taking means of thedata of the four age groups in order toreach some conclusions.Figure 1 shows the means of the datafor 100 grams of articular cartilage solids. The single vertical cross-hatchedareas give the weight of the fiber solids,the clear areas the weight of the chondroitin sulphate and the slant crosshatched areas the cell solids. The firstthree groups up to 80 years of age havesimilar fiber, chondroitin sulphate andcell solids. In the 81-87 year-old-group,the cell solids are higher and the fibersolids are lower. If the cell solids are anindication of the chondrocyte population, it seems that the 81-87 year-oldgroup has a higher chondrocyte population. Rosenthal, Bowie and Wagonerfound that the number of chondrocytesdiminished with age. Their conclusionwas reached from studies on respirationand glycolysis of bovine costal cartilageand the cell count determinations weremade microscopically. Cell counts can bequite inaccurate because it has beenshown histologically that chondrocytescan become "clumped" with increasing8 MEDICAL ALUMNI BULLETIN PHASE MASS DATA FOR I Kg. ARTICULAR CARTIlAGE167 272o· IHzO)UllllI'IHZO)F25 274 0'IF)5600 .'CS"'5a·I¥)c;500 �'IC)5161400 IIF)291AGE YEARS 10-20 21-51 55-80 81-87GROUP I n m mFIGURE 2age and counting the individual cells insuch groups may be difficult. The"clumping" of chondrocytes with increasing age may be the reason for theincreased values for the cell solids inthis old age group. This increase maynot be absolute but merely relative tothe other solids of the cartilage.It is interesting that the means of thechondroitin sulphate weight which represents all of the mucopolysaccharidesulphates are the same for all the groups.The histologic changes that take placein the aging process involve a loss ofhomogeneity of the ground substance.Normal young articular cartilage groundsubstance stains as a uniform homogeneous mass, except for the areas immediately surrounding the chondrocytes, indicating that the collagenous portion (fiber solids) and the mucopolysaccharideshave the same index of refraction fortransmitted light. Such does not appearwith aged cartilage, for in this instancethe matrix stains irregularly and becomes"fibrillated." Such staining changes, however, may indicate degenerative processrather than simple age changes. Becauseof the fibrillation of cartilage matrix,one might be led to conclude that thefibrous portion remains intact and thatother constituents are increased, thus exposing the collagen. Biochemically, thechondroitin sulphate remains constant inweight and the collagen decreases withage. This favors the conclusion that theobserved histologic changes by loss of homogeneity and fibrillation of matrixare not normal aging processes but theresults of degeneration.Figure 2 gives the graphic representation of the means from the four groupsof patients for the phase mass data forone kilogram of fresh cartilage. Eachcolumn represents one kilogram of cartilage. The extracellular compartment(E) consists of extracellular fluid orwater designated by the ultrafiltrate(H20)u, water associated with the fibersolids (H20)F, and the extra-cellular solids, consisting of fiber solids (F)s +chondroitin sulphate mass CSAs. Theintracellular compartment (C) consistsof intracellular water (H20)c and cellsolids (C)s'TOTAL WATER,CHONDROCYTE WATER ANDEXTRACELLULAR WATER PER KQ. CARTILAGE100 783765 765 760... " TI ... ". 10-20 ZI-51 sa-IO 11-17p�p 1 I • mm. vms CHOND"OCYTE .... TER+0.- EXTIIACELLULAR .ATERFIGURE 3SolidsAs expected, from the data from the100 grams of cartilage solids (Fig. 1)the highest value was in the oldest agegroup and the smallest in the young agegroup; the mean weights of the mucopolysaccharide sulphate solids in all agegroups were the same and the fiber solids were lower in the 81-87 year-oldgroup.WaterThe chondrocyte water or cell waterper kilo of cartilage in group I, 10-20years of age and group 11,21-51 yearsof age were 238 and 249 grams respectively with cell solids of 41 and 46 gramsrespectively (Figure 3). The percentagesof cell water were therefore 85 per centand 84 per cent. We can conclude thatthe cell water content in these groups isnot different. However, in group III, 55-80 years of age, the water in the cell was317 grams with a solid of 44 grams, giving a percentage of intracellular waterof 88 per cent, which is higher than in:.E •. RELATIONSHIP OF ANa WITH mM SULFATEPER Kg. CARTILAGETotolN.". TolalN.,.2 TOlalNo,.. TotalN.1620'6 ..0'(,.,01"�'(Fls�.mMSO.oAGE YEARS 10- 20GROUP 1 55-80m21'51n 8'-87IIIFIGURE 4the younger groups. In group IV, 81-87years of age, the cell water was 291grams and the cell solids 52 grams, giving an intracellular water percentage of84 per cent, which is comparable to theyounger groups. Thus the content of intracellular water in all age groups conformed, with the exception of the 55-80year-old group, in which the intracellularwater was higher in content.The extracellular water (H20)u +(H20)F, as well as the cell water ingroups I and II, are very similar. Ingroup III, the 55-80 year-old-group, theultrafiltrate volume is low when compared with groups I and II, which mustbe the result of a shift of water to thechondrocyte phase. The oldest age group(IV) had the largest total water content(78.3 per cent). The other groups had 76per cent. Group IV had the lowest valuefor connective tissue solids and, accordingly, a lower connective tissue water.Thus the extra water shifted from theextracellular phase to the cell phase,which contains a high cell solid value,and in this way maintained a constantintracellular water percentage. Thesewater partitions are shown in Figure 2.Therefore, considering the phases in articular cartilage, no changes were founduntil the patients reach 50 years of age,and then the extracellular phase with itscollagen and polysaccharide sulphate become somewhat drier.The relationship of sodium to chondroitin sulphate in cartilage, as shownin Figure 4, is vital. The means of thetotal determined values of sodium andsulphate are shown by the columns ineach group. In the figure, it will be noted that the ll. Na values run quite parallelto that of the sulphates; that is, whenthe ll. Na is high the sulphates are high,and conversely. No attempt was madeto separate the chondroitin sulphates,but Martin Mathews has shown that allthree chondroitin sulphates behave asflexible unbranched polyelectrolytes withsimilar chain configuration-charge relationships, and the same range of molecular weights was found in all three specimens.In 1959, Kaplan and Meyer found inthe costal cartilage of human beings alinear decrease in chondroitin sulphatefrom birth to old age and an increase inkeratosulphate concentration in proportion to the age of the subject. Theyshowed that the keratosulphate contentreaches a plateau at 20 to 30 years ofage and remains constant even in sene-CONCENTRATION OF POTASSIUMPER Kg. CHONDROCYTES ANDPER Kg. CHONDROCYTE WATERIIIID.M.Eq K/KQ CHONDROCYTED· M.Eq, K I(Q.CHONDROCYTE WATEft20.GE�Ws 10-20"-- 21-51- 55-80GROUP J 11 81-87IIIFIGURE 5scence. Since we determined the total sulphate after hydrolysis of the tissue wecould not partition the sulphate contentinto chondroitin sulphate and keratosulphate; therefore, our total SUlphate hasto represent their sum. This explainswhy we obtained the same amount ofsulphate in all our patients regardless ofage.Since we are interested in weights ofthe mucopolysaccharides in order to illustrate the phase mass data for a kilogram of cartilage, the calculation of themass of this phase would not be alteredby the fact that, according to Meyer,Linker, Davidson and Weismann, keratosulphate is a polymer of galactose, Nacetyl glucosamine and sulphate in equalproportions.Using these histochemical patterns forone kilogram of cartilage, we consideredthe distribution of potassium in order to determine whether the chondrocytes during aging maintain their intracellularconcentration of this cation. (Figure5) Can the larger amount of potassium in the 10-20 year group indicate that the chondrocytes are growingor are more viable at that age? After20 years of age, can the constant valuesfor potassium indicate no significantchange in cell population with the agingprocess? We found that not only wasthe concentration of potassium in thechondrocytes very constant in amount,but the percentage of cell water was also very constant, indicating the orderlydistribution of these molecules in thecells.In summary, the particular propertiesthat we have used to characterize cartilage have been presented; that is, theextra- and intracellular patterns andtheir systems. From these patterns thefollowing deductions were made:SolidsThe highest value for total cell solidsper kilo of cartilage occurred in theoldest age group, and the smallest valuein the young age group. The mucopolysaccharide sulphate solids were the samein all age groups. There is a possibilitythat in the old age group the mucopolysaccharide sulphates include the chondroitin sulphate plus some keratosulphate. The fiber solids were lower in the81-87 year group, thus causing the totalsolids of this group to be the lowest.WaterConsidering the water in the phases,no changes were found until the patientsreached 50 years of age, and then theextracellular phase became somewhatdrier. The percentage of water in thechondrocytes conformed in all agegroups with the exception of the 55-80 year-old-group, in which the intracellular water was higher in content.PotassiumThe concentration of potassium in thechondrocytes, as well as the percentageof water, is very constant indicating theorderly distribution of these moleculesin the cells. The largest amount of potassium was in the 10-20 year-old-group,indicating that the chondrocytes in thisage group are growing or are more viable. After 20 years of age, the constantvalues for potassium indicate no significant change in the cell population withthe aging process.The data demonstrate that minimalchanges were found in normal articularcartilage during the aging process.MEDICAL ALUMNI BULLETIN 9THE SENIOR10 MEDICAL ALUMNI BULLETIN ADAMS, JULIABorn Oct. 9, 1935; Western College for Women,B.A., 1956; Intern.: Albert Einstein Medical Center,Philadelphia, Rotating; Unmarried; Box 362, Industry,Pa.ANDREWS, THOMAS WENTZBorn July 27, 1937; Hiram College, B.A., 1959;Intern.: Cleveland Clinic H.; Dermatology; Unmarried; Route 3, Boyertown, Pa.ANDRUEZK, ROBERT CORWINBorn Jan. 7, 1938; Illinois Wesleyan, B.A., 1959;Intern.: Lackland A.F .B.H.; Surgery; Married; 2013Buchanan, Springfield, Ill.ANTOINE, JOHN EUGENEBorn May 28, 1937; Beloit College, B.S., 1959;Intern.: San Francisco Gen. H.; Radiology; Unmarried; 402 Main St., Belgium, Wisc.BAGWELL, HOWARD ROBERTSBorn Jan. 25, 1938; Northwestern U., B.A., 1959;Intern.: U.S.P.H.S. H., San Francisco; Psychiatry;Unmarried; 10640 S. Seeley, Chicago 43.BARTON, M. DENNISBorn Sept. 22, 1937; U. of C., B.S., 1959; Intern.:King County H., Seattle; Anesthesiology or InternalMedicine; Married; A.O.A.; 1750 Quebec, Denver 20,Colo.BASS, HAROLD NEALBorn April 14, 1939; U. of C., S.M., 1963; Intern.:Chlidren's Mem. H., Chicago; Pediatrics; Married;2249 E. 81st St., Chicago 17; 9319 S. Constance Ave.,Chicago 17.BISSELL, DAVID DEWEYBorn August 29, 1937; U. of Rochester, A.B., 1959;Intern.: Children's H. of Michigan, Detroit; Pediatrics;Married; One child; A.O.A.; 28 Prospect St., Attica,New York.BONNER, JOHN THOMASBorn Dec. 7, 1936; Carroll College, Helena, Mont.,A.B., 1959; Intern.: Duke H., Durham, N.C.; Neurosurgery; Unmarried; 744 W. Galena St., Butte, Mont.BORDEN, THOMAS ALLENBorn August 31, 1937; Earlham College, B.A., 1959;U. of C., M.S., 1963; Intern.: Billings; Surgery;Married; 5305 S. Kimbark, Chicago 15.BORGE, GEORGE FRANKBorn Sept. 10, 1938; St. Joseph's College, A.B.,1961; Intern.: U .S.P .H.S. H., Seattle; NeurologyPsychiatry; Married; One child; 1030 Kemman,La Grange Park, Ill.BRA Y, GEORGE ALEXANDERBorn April 18, 1938; Montana State College, B.S.,1961; Intern.: Mary Hitchock Mem. H., Hanover,N.H.; ENT; Married; One child; 510 Anderson St.,Big Timber, Mont.BRODER, JUDITH TUSHNETBorn July 31, 1940; U. of Chicago, B.S., 1960;Intern.: Michael Reese H., Chicago; Pediatrics; Married; 2901 S. Parkway, Chicago 16.DAWLEY, JOHN AVERILLBorn Jan. 27. 1937; U. of So. Dakota, B.S.M., 1961;Intern.: Billings; Neurosurgery; Married; Two children; A.O.A.; 6721 Chappel, Chicago 49.DeYOUNG, DIRK VERNONBorn March 12, 1936; U. of C., A.B., 1956, S.B.,1959; Ph.D. candidate in pathology; Unmarried;Apt. 1417, 2851 S. Parkway, Chicago 16.CLASS OF 1963EPSTEIN, PHILIP SAMUELBorn Nov. 12, 1937; U. of C., S.B., 1959; Intern.:U. of Illinois Res. & Educ. H., Chicago; Psychiatry;Unmarried; 6752 Merrill, Chicago 49.ESTERLY, JAMES ALLENBorn April 3, 1937; North Central College, A.B.,1959; Intern.: Billings; Pathology; Married; Onechild; 5488 S. University, Chicago 15; Leaf River, Ill.FELL, THOMAS E.Born Feb. 27, 1938; Beloit College, B.A., 1959;Intern.: U. of Iowa H.; Surgery; Unmarried; 5830Stony Island, Chicago 37.FINEGOLD, IRABorn June 29, 1938; Brooklyn College, B.A., 1959,U. of C., M.S., 1963; Intern.: Bronx Municipal H.;Internal medicine; Married; 1895 E. 47th St., Brooklyn 34, N.Y.; 2514 E. 7th St., Brooklyn 35, N.Y.GAK, CARLBorn May 17, 1939; Intern.: Billings; Internalmedicine; Married; 5715 Drexel Ave., Chicago 37;7900 N. Octavia Ave., Niles 48, Ill.GALLAGHER, BRIAN BORUBorn Sept. 2, 1934; Notre Dame, B.S., 1956; U. of C.,Ph.D., 1960; Intern.: Billings; Neurology; Married;835 E. 56th St., Chicago 37; 136 E. 64th St., N.Y.GERNON, WILLIAM HALLBorn March 26, 1938; U. of C., B.S., 1959; Intern.:Billings; Surgery; Married; One child; 6717 Chappel,Chicago 49; 1017 W. Hill; Champaign, Ill.GITNICK, GARY L.Born March 13, 1939; U. of C., B.S., 1960; Intern.:Johns Hopkins H., Internal medicine; Unmarried;1616 N. 58th St., Omaha, Nebr.GREENBURG, A. GERSONBorn March 23, 1939; U. of C., B.S., 1959; Intern.:Billings; Surgery; Married; 2851 S. Parkway, Chicago16; 2450 N. Kedzie, Chicago 47.HANSON, SUSAN E.Born Nov. 25, 1937; Hiram College, B.A., 1959;Intern.: Robert Packer H., Sayre, Pa.; Psychiatry;Unmarried; Wittenburg, Wisc.HEFTER, LAWRENCE G.Born Sept. 13, 1938; working toward Ph.D. inPathology, U. of C.; Unmarried; 6941 Paxton, Chicago 49.HEISTED, DONALD DEANBorn April 2, 1940; Intern.: Billings; Internalmedicine; Unmarried; 5715 S. Drexel, Chicago 37;1441 N. Cleveland, Chicago 10.HENNEFORD, GORDON EUGENEBorn Sept. 7, 1938;· Intern.: U.S.P.H.S. H., Baltimore; ENT; Married; One child; Choteau, Mont.HOFFER, PAUL B.Born April 9, 1939; Intern.: Mary Hitchcock Mem.H., Hanover, N.H.; Internal medicine; Unmarried;800 Grand Concourse, Bronx 51, N.Y.KAIN, MARTIN LEEBorn Feb. 25, 1940; U. of C., S.B., 1959; Intern.:Mary Hitchcock Mem. H., Hanover, N.H.; Anesthesiology; Married; A.O.A.; 2250 Grand View Ave.,Cleveland Hts., Ohio.MEDICAL ALUMNI BULLETIN 11THE SENIOR12 M E Die A L A L U M NIB U L LET I N KAO, VINCENT CHAO YANGBorn Oct. 1, 1937; U. of Wise., B.A., 1959; Intern.:Undecided; Billings, Pathology; Unmarried; 1009E. 57th St., Chicago 37; 9, Section 2, Nan Chang Road,Taipei, Taiwan.KINNEY, MICHAEL JAMESBorn July 9, 1937; U. of C., S.B., 1959; Intern.:U.S'p.H.S. H., Staten Island, N.Y.; Undecided; Married.KNECHT, JAMES WILLIAMBorn Sept. 10, 1938; U. of C., B.S., 1960; Intern.:U. of Ill. Res. & Educ. H., Surgery; Married; A.O.A.;908 E. 56th St., Chicago; 5212 Oak Center, Oak Lawn,Ill.KONRAD, HORST REINHARDBorn Feb. 18, 1938; Intern.: Blodgett Mem. H.,Grand Rapids, Mich. ; Surgery; Married; 320 S.Spencer, Aurora, Ill.KRAINES, RICHARD LEEBorn March 14, 1939; Oberlin College, B.S., 1959;Intern.: U. of Ill. Res. & Educ. H., Medicine; Married;6817 Crandon, Chicago 49.LADDA, ROGER LOUISBorn Oct. 28, 1936; Wesleyan U., A.B., 1958; Ph.D.candidate in pathology; Internal medicine; Married;Three children; Lebanon, Ill.LAVETTER, ALLANBorn Oct. 10, 1937; Princeton U., A.B., 1959;Intern.: U.S.P.H.S. H., Boston; Pediatrics; Unmarried; 3351 Washington Blvd., Cleveland Heights 18,Ohio.LENTZNER, ROBERT CLYDEBorn May 30, 1938; Intern.: Michael Reese H.,Chicago; Internal medicine; Unmarried; 7347 NorthHoyne, Chicago.LOGAN, WILLIAM JOSEPHBorn May 9, 1938; Illinois College, A.B., 1959;Intern.: Johns Hopkins H., Pediatrics; Unmarried;Williamsville, Ill.MERCHANT, EDMUND BRUCEBorn March 26, 1935; Nebraska Wesleyan U., A.B.,1957; U. of C. post-doctoral fellow in pathology;Clinical Pathology; Married; One child; 5715 DrexelAve., Chicago 37; Box 76, Elgin, Nebr.MEYE� JERRY FRANCISBorn April 19, 1938; Intern.: U. of Ill. Res. & Educ.H. ; Internal medicine; Married; One child; 650Whitley, Joliet, Ill.MIZOCK, BERNARD JOSEPHBorn Aug. 21, 1938; U. of C., S.B., 1959, M.S., 1963;Intern.: Billings; Surgery ; Unmarried; 6500 N. Kenton Ave., Lincolnwood, Ill.MORSE, PETER HODGESBorn March 1, 1935; Harvard, A.B., 1957; Intern.:Billings; Ophthalmology; Married; 6811 Paxton, Chicago 49; 274 Clarendon St., Boston, Mass.NELSON, DONALD EDWARDBorn Feb. 18, 1937; Augustana College, B.A., 1959;U. of C., M.S., 1963; Intern.: Western Reserve U. H.,Cleveland; Pathology; Unmarried; Rt. 1, Beresford,So. Dakota.OPPENHEIM, BERNARD EDWARDBorn July 5, 1937; U. of Arizona, B.S., 1959;Intern.: Michael Reese H., Chicago; Radiology; Married; 6240 N. Richmond, Chicago.CLASS OF J963PERSON, EDWARD ALANBorn Feb. 5, 1934; San Diego State College, A.B.,1959; Intern.: U. of Maryland H.; Surgery; Married;One child; 3511 Elliott, San Diego 6, Calif.PLATZ, CHARLES EDWARDBorn Sept. 13, 1937; U. of Kansas, A.B., 1959;Intern.: U.S'p.H.S. H., Staten Island; Pathology;Married; Two children; 211 W. 11th Ave., Hutchinson, Kansas.QUANBECK, STANLEY DWIGHTBorn April 3, 1937; Augsburg College, B.A., 1959;Intern.: Ancker H., St. Paul; General Practice; Married; Betioky-Sud, Madagascar.ROSANSKY, ALLAN BRUCEBorn Aug. 7, 1937; U. of C.; B.S., 1959; Intern.:Pennsylvania H., Philadelphia; Internal medicine;Unmarried; 1319 Euclid Ave., Steubenville, Ohio.ROSE, SELWYNBorn Aug. 12, 1935; U.C.L.A., A.B., 1956; Intern.:Cedars of Lebanon H., Los Angeles; Psychiatry; Unmarried; 8338 Clinton Ave., Los Angeles 48.ROTHMAN, DONALDBorn Dec. 16, 1937; U. of Pennsylvania, A.B., 1959;Intern.: Bronx Municipal H., N.Y.; Surgery; Unmarried; 101 Waltuma Ave., Fords, New Jersey.SCHACHTER, HOWARDBorn Sept. 26, 1938; U. of C., S.B., 1959; Intern.:Billings; Medicine; Unmarried; 823 W. Montrose,Chicago 13.SCHLOSSMAN, CHARLES MICHAELBorn Jan. 11, 1937; U. of C., B.S., 1959; Intern.:King County H., Seattle; Pediatric neurology; Unmarried; 4422 N. Harding, Chicago 25.SCHNEIDER, JOHN FREDERICKBorn Sept. 8, 1936; De Pauw, B.A., 1958; Intern.:U. of Washington H.; Internal medicine; Unmarried;A.O.A.; 6232 N. 11th St., Phoenix, Ariz.SCHWEITZER, LAURENCE ROYBorn May 15, 1937; Rutgers U., A.B., 1959; Intern.:U.S.P.H.S. H., Seattle; Psychiatry; Unmarried; 32Bond Street, Passaic, N.J.SILVERMAN, MARK EDWINBorn June 21, 1939; Ohio State, B.S., 1960; Intern.:Ohio State U. H.; Internal medicine; Unmarried;1524 Earlham, Dalton 6, Ohio.STONE, MARVIN JULESBorn Aug. 3, 1937; U. of C., M.S., 1962; Intern.:Barnes H., St. Louis; Internal medicine; Married;Two children; A.O.A.; 790 Washington, Denver, Colo.SVOBODA, WILLIAM BANCROFTBorn Dec. 10, 1936; Hastings College, B.A., 195_9;Intern.: Billings; Pediatrics; Married; 5417 S. Woodlawn, Chicago 15; 239 W. 6th St., Fremont, Nebr.THWIN, MAUNG KYIBorn Feb. 10, 1939; Beloit, B.S., 1959; Intern.:Base Military H., Rangoon, Burma; Unmarried;Dagon Tobacco Co., Ltd., 123 Sule Pagoda Rd.,Rangoon, Burma.WERNER, PETER WILLIAMBorn April 4,1937; U. of C., B.S., 1959; Intern.:U. of Iowa H.; Internal medicine; Unmarried; 1624W. l00th Place, Chicago 43.ME 0 I CAL A l U M NIB U II E TIN 13THE SENIOR CLASS OF 1963WHITE, JOSEPH GEORGEBorn July 9,1938; Ripon Coll., A.B., 1959; Intern.:Bronx Municipal H.; Surgery; Married; 301 S. 3rd St.,Oregon, Ill.WHITE, ROBERT JOHNBorn Sept. 17, 1938; Syracuse U., B.A., 1960;Intern.: Geisinger Medical Center, Danville, Pa.; Pediatrics; Married; One child; 99 Seminole Ave., Oakland, N.J.WHITE, WILLIAM DOYLEBorn July 15, 1938; U. of Arkansas, B.A., 1959;Intern.: U. of Arkansas H.; Undecided; Married;Two children; 7305 Apache Road, Little Rock, Ark.WOLINSKY, HARVEYBorn June 3,1939; Western Reserve U., A.B., 1960;Intern.: Billings; Unmarried; A.O.A.; 3758 BainbridgeRd., Cleveland Heights, Ohio.WOODSON, ROBERT DAVIDBorn Aug. 28,1938; Houghton College, A.B., 1959;Intern.: Peter Bent Brigham H.; Internal & tropicalmedicine; Unmarried; 1420 Old State Rd., Covington,Kentucky.ZA]TCHUK, ROSTIKBorn Jan. 8, 1939; U. of C., B.S., 1960; Intern.:Billings; Surgery; Married; 327 W. 76th St., Chicago20; 2510 W. Walton, Chicago 22.SENIOR SCIENTIFIC SESSIONThe Effects of Hypoxia andCarbon Dioxide Stimulationon Respiratory Drive underVarying Levels of Halothane AnesthesiaBy DENNIS BARTON and HORST KONRADAnesthesiologyRespiratory depression under halothane anesthesia has been observed sincethe inception of studies on this agent.CO2 and O2 concentration are both concerned in respiratory drive. A decreased sensitivity to CO2 concentrationhas been noted in animals and patientsunder halothane anesthesia. The responseto O2 concentrations with halothaneanesthesia has not been well studied.Since the CO2 sensitivity is diminished, we wanted to determine whetherthe response to O2 concentration becomes a more important mechanism inmaintaining respiratory drive.Four mongrel dogs were trained toreceive halothane anesthesia. They were14 MEDICAL ALUMNI BULLETIN then subjected to 1, 1.5, 2 per centhalothane. Expiratory minute volumewas measured for varying concentrations of O2 (from 10-100 per cent),and for room air and 7 per cent CO2at each level of halothane.As the percentage of halothane wasincreased, hypoxic stimulation becamerelatively greater than stimulation with7 per cent CO2, From these results weconclude that under halothane anesthesia, particularly at high concentrationof halothane, respiratory response toO2 concentration becomes an importantmechanism in maintaining respiratorydrive.The Effects of Urease ImmunityUpon Rats with ControlledVitamin A AdministrationBy HAROLD N. BASSPharmacologyThis study was performed to evaluatethe effects of urease immunity on nutrition in rats with controlled Vitamin A administration. The nutritional aspectsstudied were weight gain, feed efficiency,gastrointestinal ammonia concentrationand urea hydrolysis, Vitamin A storage,histological changes and Vitamin Autilized for growth.Three experiments, each lasting eightweeks, were conducted with weanlingmale Sprague-Dawley rats. The animalswere placed on a USP XIV VitaminA-deficient diet. During the first fourweeks, one-half of the animals wereactively immunized with crystallinejackbean urease, while the other halfreceived normal saline. During thelatter four weeks the animals receiveddaily oral doses of Vitamin A. Thelevels of Vitamin A administered were2.2 International Units (IU), 22 IU,70 IU, 220 IU' and 700 IV. With 2.2IU, which was at the recommendeddaily allowance, the immunized groupsgrew faster and utilized their feedmore efficiently than the controls. At70 IU and above, immunization had nosignificant effects on growth rate orfeed efficiency. Immunization depressedammonia concentration and urea hydrolysis in both intestines regardless ofVitamin A level but did not alterhepatic Vitamin A storage or producehistologic changes in several organs.Since hepatic storage of the vitaminwas identical in both the immunizedand control groups, it was felt thatimmunity-induced growth increases weredue to either increased absorption ormore efficient utilization of Vitamin Afor growth. A fourth study to evaluatethe latter hypothesis was undertaken. Itwas found that the immunized animalsrequired significantly more vitamin perunit of weight gain, thus eliminatingsparing effects on utilization as amechanism for enhanced growth byimmunity.It is concluded that urease immunitydepresses ammonia concentration andurea hydrolysis presumably throughcross-reactions between urease antibodyand bacterial urease(s) in the gastrointestinal lumen. Immunization alsoenhances growth and feed efficiency ator below the recommended daily Vitamin A allowance. The immunity appearsto exert its growth effects through increased absorptive capacities for fatsoluble vitamins.Preliminary Observation ofDegeneration in the EmbryonicChick Spinal CordBy JOHN T. BONNERAnatomyLesions were made with cold cauteryin the spinal cord of five- to eight-daychick embryos at the level of origin ofthe wing buds. After a post-operativesurvival period of seventeen hours tothree days, the embryos were fixed andprepared by the pyridine-silver methodfor study. Observation of serial sectionsrevealed almost complete absence ofneural elements at the area of maximallesion. Rostral and caudal to the site degenerated axons were seen.In this preliminary study, the reportis limited to effects observed in the ventral roots and the dorsal funiculi. Distorted and swollen axons, as well asbulbs, rings and argentophilic fragmentsreplaced the normal axons, and weresimilar in appearance to those describedby Cajal and others. In one embryo, thedegenerating dorsal funiculus could befollowed for over two hundred microns,indicating that study of developingtracts in the embryonic nervous systemmight be accomplished in this manner. The embryos were not kept long enoughto make studies on regeneration. Thepresent work is being done preparatoryto studies on regeneration contemplatedin the future.Fats, Rats and Estrogens(A Physico-Chemical Study ofthe Lipoprotein System ofthe Normal Estrogen-TreatedMale Rat in Relation toAtherosclerosis)By THOMAS A. BORDENPathologyPre-menopausal women enjoy a relative immunity to coronary atherosclerosis. It has been suggested that this immunity might be related to estrogen-induced changes in serum lipoproteins.Moskowitz demonstrated in long-termexperiments that in rats, estrogens mayindeed serve a prophylactic function.Paradoxically, he found that estrogensaugmented the development of atherosclerosis when similar experiments weredone on a short-term basis. The mechanism of this intriguing dichotomy inestrogen action was not explained andvirtually nothing was known about ratlipoproteins. Therefore, the purpose ofour experiments was twofold: (1) to disclose some of the physico-chemical properties of the lipoprotein system of thenormal male rat and (2) to demonstratethe influence of an atherogenic (highfat) diet with and without estrogens onthis lipoprotein system.Our experiments demonstrated thatthe rat has three chemically and physiologically distinct lipoproteins. In contrast to humans, the rat has a very lowdensity "beta," a low density "alphaj,"and a high density "alpha!" lipoprotein.The cholesterol and phospholipid ofthe high density lipoproteins were significantly elevated by high fat diet whilethe very low and low density lipoproteins were relatively unaffected. Estrogen plus high fat diet induced an evengreater elevation in cholesterol and phospholipid in such a way that the cholesterol/phospholipid ratio was decreasedin both the high and low density lipoproteins with the greater effect on thelatter. These results are quite unlikethose reported for humans.In short term experiments, estrogenproduced an increase in the beta/alphalipoprotein ratio, an elevation in thevery low density lipoprotein cholesterol/phospholipid ratio, and a sparing of theliver from lipid deposition. All thesephenemona which are associated with atherogenesis in other species, disappeared with time. This may in part explain the acute deleterious effects estrogens are reported to have in the treatment of atherosclerosis.Increased Arterial Permeabilityin Hypertensive RatsBy JAMES A. ESTERLYPathologyThere is evidence that hypertension isassociated with an increase in the severity and rate of development of arteriosclerosis in man. Intimal atheromatouslesions in hyperlipemic rats, rabbits,monkeys, and dogs are accentuated byhypertension.The passage of cellular elements intothe intima may be a factor in atherogenesis; evidence for this has beenshown experimentally in hyperlipemicrabbits and rats. Hypertension may result in increased permeability of the intima to both formed and dissolved bloodconstituents. This increased permeabilityand the mechanical effect of elevatedblood pressure on endothelial and smoothmuscle cells may account in part for thepotentiating effect of hypertension onthe development of atherosclerosis.Evidence of increased intimal permeability to blood elements and damage toendothelial and smooth muscle cells wasdemonstrated by electron microscopy inthe hypertensive rat. Right nephrectomized rats drinking 1 per cent saline became hypertensive within three weeksafter subcutaneous implantation of apellet of desoxycorticosterone acetate(DOCA). At eight weeks the left mainrenal arteries were fixed in situ withosmic acid; vessels were fixed while distended at a controlled pressure to minimize shrinkage and distortion.The following lesions were abundantin the main renal artery of the hypertensive rats: (a) vacuolization and degeneration of endothelial cells; (b) adhesion of blood cells to the endothelium;(c) widening of the subendothelialspace; (d) accumulation of blood cellsand cell fragments in the subendothelialspace; (e) vacuolization and degeneration of smooth muscle cells; and (f) accumulation of extracellular osmophilicmaterial in the media. Uninephrectomized rats and uninephrectomized ratsdrinking saline showed little or no risein blood pressure and no lesions.These findings suggest that hypertension and/or other hemodynamic modifications may alter the permeability of thearterial wall. This may be one of theME 0 I CAL A L U M NIB U LL E TIN lSmechanisms by which hypertension enhances the development of atherosclerosis.Transplant Immunity andImmunological EnhancementBy IRA FINEGOLDPathologyThe transplantable tumor has provedto be a highly useful implement in theimmunological approach to the study ofexperimental neoplasia. Such tumorshave been used to study the host response to cancer and the nature of cancer antigens as well as the principles oftissue homografts. In some instancesprevious immunological experience with_ a tumor or its antigens will confer somedegree of immunity in the host to a second graft of the same tumor. Humoralantibody may confer protection againstsome tumors in a host, but in some selected systems the administration ofhomologous or heterologous antibody iscapable of producing increased or enhanced growth of the graft. Thus itwould appear that the tumor-host balance can be influenced by both activeand passive immunity.The interaction between transplantimmunity and immunologic enhancementwas investigated. CF-1 mice were givena subcutaneous Ehrlich tumor transplantwhich was removed after one week.These mice were challenged with a second subcutaneous tumor. In mice bearing a second tumor, there were fewertumor acceptances, smaller tumors andan increased incidence of regressionwhen compared with mice bearing onlyan initial tumor. This was interpreted asclear evidence that in the mice receivingone tumor and having it excised, therewas host resistance or transplant immunity against the challenge tumor.Various doses of anti-Ehrlich ascitestumor gamma globulin, prepared fromimmunized rabbits, were administeredintravenously to mice having transplantimmunity and to mice without transplant immunity. Contrary to the previously well-documented cytotoxic properties of this antibody preparation for theascites form of the Ehrlich tumor,increased growth of the tumor, decreasedhost survival and decreased tumor regression resulted from administration ofAEA gamma gobulin.On histologic examination the splenicimmune reaction appeared to be depressed by the administration of passive antibody. Immunological enhancement by specific heterologous antibody16 MEDICAL ALUMNI BULLETIN was evident even though active transplant immunity was also present. It isevident that, in this tumor host system,heterologous antibody can producecytotoxic changes or immunological enhancement in the same tumor depending on the site of the tumor. Theseexperiments emphasize that caution isnecessary in applying antibody preparations to immunochemotherapy.Experimental PhenylketonuriaBy BRIAN GALLAGHERMedicineHomozygous phenylketonuric patients,unable to hydrolyze phenylalanine totyrosine, are characterized by dermatitis, diminished pigmentation and mental retardation. The relation of centralnervous system dysfunction to aberrant metabolism remains an enigma.However, approach to the problem isafforded by the observation that overloading the diet of rats with the substrate and product of phenylalaninehydroxylation (phenylalanine and tyrosine respectively) inhibits the sameenzyme that is defective in phenylketonuria.In a preliminary experiment employing such a diet, adult albino rats wereshown to excrete urinary metabolitescharacteristic of phenylketonuria, yetthese animals were no different fromcontrol rats' in ability to perform inthe complex Hebb- Williams maze. Asecond experiment employing matchedgroups of albino rats, twenty, forty,sixty and eighty days old, demonstrateda significant behavioral defect in thetwenty-day-old rats fed the experimentaldiet with a trend in the same directionin the forty-day-old animals and nodefect in the older two groups. Thissusceptibility of young animals to thetoxic effects of a diet simulating themetabolic derangement of phenylketonuria with sparing of older animals isconsistent with current knowledge ofthe disease and opens a new approachto elucidation of the central nervoussystem defect.Gastric Neoplasm: Accuracyof Diagnosis of Radiology,Cytology, Gastroscopy andGastric AcidityBy PAUL B. HOFFERRadiologyOur project involved the study and comparison of the value of radiology,cytology, gastroscopy and gastric aciditytests in the diagnosis of gastricneoplasm.Two groups of patients were chosenfor study. Group I consisted of all ofthe ninety-five cases of gastric neoplasmfirst diagnosed at the University ofChicago hospitals and Clinics duringthe period starting January 1, 1958and ending December 31, 1961. Eightyeight of these patients were_ clinicallyevaluated prior to pathologic confirmation of their neoplasm. Group II consisted of 224 randomly selected casesof benign gastric ulcer initially diagnosed at our institution during the sameperiod. This latter group was selectedas a clinical "control" group to determine the incidence of false-positivediagnosis of malignancy.In the evaluation of radiologic, cytologic and gastroscopic examinations,only the first report diagnosis in eachcase was recorded. For gastric acidity,the highest value of any test duringthe evaluation period was recorded.Analysis of Group I revealed thatfirst radiologic examination detectedabnormalities in 93 per cent of casesof gastric neoplasm. Radiology, cytologyand gastroscopy, taken individually,were equally successful in establishingabout 80 per cent of cases as eitherquestionably or definitely neoplasm.Only 57 per cent of the group testedwere achlorhydric. When two or moretests, including the radiologic examination, were used in evaluating a patient,the accuracy of diagnosis was 100 percent.In Group II, patients with benigngastric ulcer, cytology revealed nofalse-positive diagnosis of malignancy.Radiology and gastroscopy each revealed false-positive diagnosis of malignancy in about 5 per cent of casesand were unable to differentiate betweenbenign and malignant in an additional10 per cent of cases. The incidence ofachlorhydria in Group II was less than1 per cent.We feel our results confirm the valueof radiology as the initial test for suspected gastric lesions while at the sametime emphasizing the value of the useof two or more tests to establish adiagnosis.Our project also involved a detailedstudy of the radiologic method of diagnosis of gastric neoplasm. The resultsof that study are too extensive to beincluded in this summary.Experimental Lead Poisoning:Light and Electron MicroscopicStudy of Changes in Renaland Hematopoietic TissueBy ROGER LADDAPathologyA small amount of lead is normallypresent in the body, but serves noknown useful physiological function.Man and animals chronically exposed tolead compounds in the air breathedand/or food ingested develop a hypochromic hypersideremic anemia andpathogromonic intranuclear inclusionsin the proximal tubule of the kidney.The purpose of this study is to better define the chemical composition ofthe intranuclear inclusion, correlatechanges in renal and hematopoietictissues, and to study the various patterns of reaction to injury in theproximal tubule cell.Animals were maintained on a chowdiet containing 1 per cent lead acetatefor three months. By three months,erythroblasts of spleen and bonemarrow revealed marked basophilicstippling. By electron microscopy, thebasophilic bodies are shown to bealtered mitochondria containing a denseferruginous material in the matrix. Thisfinding is identical to the lesions described by Bessis and Breton-Gorius inthalassemia. Macrophages become engorged with breakdown products ofphagocytized red blood cells.Renal proximal tubule intranuclearinclusions develop simultaneously tothe hematopoietic lesions. The inclusionconsists of a dense central fibrillar zonesurrounded by two lighter and denserzones also consisting of fine tubularstructures. The inclusions are frequentlymultiple and extend the peripheralfibrillar structures throughout the nucleus. DNase decreases the centraldensity while RNase action decreasesthe overall coarse tubular structure ofthe inclusion suggesting altered nucleoproteins.Cytoplasmic changes are prominentin the proximal tubule cells. Nucleusis large located near the base of thetubular brush border. Nucleoli are enlarged. Granular vesicles, myelin figureslipid droplets, and ferritin particles ar�formed indicatihg absorption of filteredmaterial derived from breakdown ofdefective red blood cells. Mitochondriaare markedly decreased. Tubular basement membranes are stratified and contain ferruginous vesicles. The interstitial capillaries contain large masses of ferritin particles and lipid bodies.Anaplastic changes are found inproximal tubule cells suggesting anearly enoplastic process. Radioactivetracer studies indicate an altered rateof mitosis of renal cells.The mitochondrial change of erythroblasts and intranuclear inclusion ofproximal tubule may indicate theprimary site of metabolic derangementin each tissue. Proximal tubule cytoplasmic changes depend on the degreeof hemolysis with reabsorption of filteredhemoglobin and on mitochondrial alterations.Acid Phosphatases of theFrog EggBy BERNARD J. MIZOCKPhysiologyThe acid phosphatase activity of thefrog egg can be ascribed to at leasttwo separable enzymes. The first enzymeseems best characterized tentatively asa pyrophosphatase; the second is thehitherto-identified phosphoprotein phosphatase. The pyrophosphatase is extractable from acetone-powder preparedfrom the ovaries of the leopard frog,Rona pipiens, by distilled water oracidic solutions of low ionic strength.The partially-purified enzyme is freeof phosphoprotein phosphatase activity.It is highly active against inorganicpyrophosphate and a number of organicpyrophosphates. It has little or noactivity against a variety of simplephosphate esters although it does hydrolyze several phenyl phosphates. Thepyrophosphatase has optimum activityat pH 4.0 and appears to have no cofactor requirement. It is inhibited byphospate and molybdate and is relatively stable to heat and acid. The phosphoprotein phosphatase can be obtainedrelatively free of pyrophosphatase byextraction of the water-washed acetonepowder with 0.1 M sodium citrate. Although this enzyme is not, as yet, wellcharacterized, it can be distinguishedfrom the pyrophosphatase by the factthat it is neither heat-stable nor inhibited by molybdate.Induction and Transplantationof a Murine Viral LeukemiaBy CHARLES E. PLATZPathologyThe experiments to be reportedfollowed an unexpected observationduring studies concerned with transplantation. To test the heterotrans- plantability of AKR mouse leukemia, aknown number of leukemic cells wasinjected intra peritoneally or intravenously into newborn Wistar rats. Twomanifestations of leukemia, referred toas "early" and "late" leukemia weredistinguishable in these rats.' Earlyleukemias occurred after one to twomonths in 43 per cent of the recipients,while late leukemias appeared afterthree to six months in 10 per cent ofthe rats. Early leukemias were readilytransplanted back to young adult AKRmice and serially passed in rats. Incontrast, late leukemias failed to growin AKR strain of mice. These differenttransplantation characteristics suggesteda different etiology for the two formsof leukemia. Early leukemias were considered heterografts retaining the immunogenetic identity of the donor cell,whereas late leukemias were interpretedas neoplasms induced by the leukemiavirus in which the leukemic cell was ofthe recipient type.Late leukemias were then seriallytransmitted by cell-free filtrates throughthree generations of neonatal rats. Bythis procedure the leukemia incidencewas increased from 10 to 87 per cent.Leukemias were also induced in newborn rats by inoculation of cell-freefiltrates derived directly from theleukemic tissues of AKR mice. Theleukemia incidence in rats was 43 percent and was increased to 92 per centafter three serial passages. The latentperiod was reduced from five monthsto two months.The Effects of Polyoma Viruson Fetal RatsBy HOWARD SCHACHTERPathologyPolyoma virus is known to inducemultiple benign and malignant neoplasmsin rodents. Aside from such viral factors as dose, strain differences orhemagglutinating properties, host' factors are most important in determiningth� oncogenic response. For example,mice develop multiple epidermal andmesenchymal neoplasms after a longlatent period, while rats respond topolyoma-virus injection by the formationof mesenchymal neoplasms alone, aftera considerably shorter time. Moreover,the tumor-susceptible period in bothspecies does not extend beyond the firstten days post partum. Thereafter injection of polyoma virus results in theformation of only virus-neutralizingantibodies, without tumor development.ME 0 I CAL A L U M N I 8 U L LET IN 17Thus, the oncogenic response is determined primarily by the immaturity ofcertain host tissues at the time ofvirus application. Because tumor formation might occur in tissues normallyresistant at birth to viral oncogenesis,the effects of polyoma virus on fetalrats have been studied.Two experiments will be reported.In one, pregnant polyoma-free rats wereinoculated intravenously with largedoses of a standardized polyoma-viruspool at various days of gestation. Although the intrauterine and postnatalmortality was high, no polyoma tumorsor other lesions were found in any ofthe offspring, suggesting that the viruswas unable to cross the placental barrier. In a second experiment, polyomavirus was injected directly into thefetuses at different days of gestation.Most of the injected rats were bornalive, but they died as early as eightdays post partum from multiple vasoformative tumors, mostly cavernoushemangiomas, in the central nervoussystem. The cause of death was almostinvariably due to hemorrhage from thehemangiomas, leading to subarachnoidand subdural hematomas. A variety ofsarcomas occurred in other tissues inseveral of the surviving rats. Injectionof fetal rats with polyoma virus didnot augment the tumor spectrum whichhad previously been observed in animalsinjected during the first ten days postpartum.In Vitro Cysteine Synthesisin Rat Liver MitochondriaBy JOHN F. SCHNEIDERBiochemistryThe mammalian dietary requirementfor methionine, which can be met inpart by cysteine, is well known, as aredata showing the conversion of methionine to cysteine. On the basis of theseobservations, it has been assumed thatcysteine can be synthesized in mammalsonly from the preformed amino acidmethionine. However, it has never beenestablished whether mammalian tissuecan or cannot synthesize cysteine frominorganic sulfur. A mechanism wherebyinorganic sulfur might be incorporatedinto cysteine is provided by the recentdemonstration of a metabolic intermediate containing highly reactivesulfur formed in the rhodanese-catalyzedreduction of thiosulfate to sulfide. Thisis a new biological role for rhodanese,which is known to transfer sulfur fromthiosulfate to cyanide producing thio-18 MEDICAL ALUMNI BULLETIN cyanate, thus serving to detoxify thecyanide.Rat-liver mitochondria, which contain essentially all of the rhodaneseactivity of the cell, were shown to display a high level of sulfide generationfrom thiosulfate. The addition of "outerlabeled" thiosulfate (S35S03 - -), cysteine, serine, and pyridoxal-5-phosphateto disrupted mitochondria in buffer atpH 8.3 in the presence of O2 resultedin the incorporation of the sulfur-35into material which migrated as cysteine on zone electrophoresis at pH4.7. Omission of serine, cysteine, orpyridoxal-5-phosphate prevented or diminished this incorporation. No sulfur-35 was incorporated when "innerlabeled" thiosulfate (SS3503 - -) wasused as the labeled substrate. Additionof a 3-fold excess of unlabeled sulfidefailed to depress the level of incorporation.From the above data it may be concluded that the "outer" sulfur of thiosulfate can be a direct precursor ofcysteine sulfur in mammalian tissue notrequiring sulfide as an intermediate inthis process. A mechanism for cysteinebiosynthesis is suggested in which themetabolic intermediate, lipoate persulfide, formed from thiosulfate byrhodanese, reacts with an amino acrylicintermediate formed from serine andpyridoxal-5-phosphate.Combined Inhibitory Effectof Antitumor Antibody andan Oncolytic Virus on theSolid Ehrlich TumorBy MARVIN J. STONEPathologyRecent studies have demonstratedthe tumor-inhibiting properties of heterologous antisera made against theEhrlich ascites tumor. The presence offree tumor cells in the peritoneal cavityprovides a means whereby intraperitoneally injected antibody may easilycontact the cells in vivo. However,previous attempts at selective localization of intravenously injected antibodyin solid tumors have been largelyunsuccessful. One factor responsiblefor this failure may be the relativelylow permeability of the capillary bedof the tumor to the large globulinmolecules. If so, circulating tumorantibody, even though potentially cytotoxic and fairly specific, would havelittle therapeutic effect. An oncolyticvirus, Egypt 101, was employed in an effort to increase the permeability ofthe tumor capillaries prior to the administration of antitumor antibody.CF 1 mice with well-established subcutaneous Ehrlich tumors were randomly 'distributed and injected with thevirus four to seven days prior to theintravenous injection of anti-Ehrlichascites (AEA) y-globulin. Control groupsincluded those receiving virus alone,antibody alone, normal mouse brain,normal rabbit y-globulin and no treatment. Tumor weights were-computedat one, four and five days after they-globulin injections.It was found that combined therapywith Egypt 101 virus and AEA Y:globulin significantly inhibited thegrowth of the solid Ehrlich tumor(P<0.05), although no significantinhibitory effect was noted with eitherthe virus or y-globulin alone. Whennormal rabbit y-globulin was used incombination with the virus or whennormal mouse brain was used wi th theAEA y-globulin, no inhibitory effect onthe tumors was obtained.The mechanism of the combined inhibitory effect remains obscure. The"capillary barrier" may be an importantfactor in the localization of antibodyin solid tumors. However, results fromexperiments in which radio labeled antibody was used showed no greater localization of radioactivity in tumors fromvirus-treated animals than from controls.Structural Basis for theMechanical Properties ofthe Aortic MediaBy HARVEY WOLINSKYPathologyThe arrangement and interrelationof the structural components of therabbit aorta were studied by light andelectron microscopy. Segments of abdominal aorta were restored to in vivolength and fixed in formalin or osmicacid while intraluminal pressures ranging from 0 to 200 mm Hg were maintained by a constant pressure perfusionapparatus. Transverse, longitudinal andtangential sections of vessels fixed atvarious distending pressures were examined. Micrometric measurements included vessel diameters and wall thicknesses, thickness of elastin lamellae andinterlamellar distances.With increasing pressure below diastolic values, aortic radius increasedand wall thickness decreased rapidly.Waviness of the tubular elastin lamellae decreased uniformly throughoutthe wall, lamellar thicknesses decreaseduniformly but much less than interlamellar distances. A fine fibrillaryelastin network connected the thicklamellae. Collagen fibers showed nodefinite orientation.At and above diastolic pressuresradius and wall thickness changed little.Elastin lamellae were straight and interlamellar distances were uniform; thefibrils of the interlamellar elastin network were aranged obliquely. Collagenfibers were arranged nearly circumferentially.The mechanical properties and organization of the collagen and elastincomponents of the aortic media indicate that the wall normally functionsas a "two-phase" material. At andabove physiological pressures, circumferentially aligned collagen fibers ofhigh tensile strength and relatively highmodulus of elasticity bear most of thestressing force; elastin lamellae andfibrils of relatively low modulus ofelasticity distribute stressing forcesuniformly.Antigens in HomograftRejectionBy ROSTIK ZAJTCHUCKSurgeryIn 1956, Billingham and associatesshowed that the power of cells to elicittransplantation immunity was independent of their intactness. During thepast seven years many investigatorshave attempted to define the chemicalnature of transplantation antigens. Therole of transplantation antigens hasbeen successively attributed to deoxyribonucleic acid or deoxyribonucleoproteins, the mucopolysaccharides similar to blood group substances, theglycoproteins and most recently to thephospholipooroteins.The aims of our work were to demonstrate the heterogeneity of transplantation antigens, to characterize these antigenic fractions chemically and immunologically and to utilize these fractions inprolonging homograft survival.Antigens were extracted from spleencells by procedures developed in our laboratory, utitizing millipore filters anddifferential centrifugation. Cell fractionswere characterized by means of paperelectrophoresis, spectrophotometry andchemical analysis.The criteria for the existence of astate of immunity was the accelerated rejection of a skin homograft. First micewere injected with cell fractions to becharacterized for their antigenic power.Two days later, they were grafted withskin of the same genetic origin as thesubstances being tested. The homograftswere inspected six days after transplantation. Complete or advanced breakdownby the sixth day demonstrated a stateof immunity. Normal homografts of sixdays standing were well healed, fullysurviving, vascularized, and hyperplastic.Results indicate the presence of atleast two chemically distinct transplantation antigens, active in very low concentrations.ARMOUR WING OPENSOn August 2nd, the new Philip D.Armour Clinical Research Building wasformally opened. The building, namedin honor of the late Philip D. Armour,philanthropist and civic leader, wasmade possible by a bequest from theArmour estate and contributions byother members of the family, matchedwith funds from the University. TheUnited States Public Health Serviceprovided a grant of $1,128,409.Opening ceremonies included a luncheon attended by members of theArmour family, of the University'sBoard of Trustees and its Council onMedical and Biological Sciences, andby the medical scientists who willdirect the research in the new building. Speakers were President GeorgeWells Beadle, Fairfax M. Cone, Chairman of the Board of Trustees, H.Stanley Bennett, Dean of the Divisionof the Biological Sciences, and LowellT. Coggeshall, Vice-President of theUniversity. A tour of the buildingfollowed.The entire sub-basement is devotedto radiation therapy and radiologicalresearch. Research in ophthalmologyis carried on at the basement level,and the first floor is occupied by newlaboratories for otolaryngology, including the Temporal Bone Bank Center.The second floor is used for expandedresearch activities of the Zoller DentalClinic and of hematology. The third,fourth and fifth floors are devoted tosurgery, including the section of neurosurgery which occupies part of thethird floor. The top floor is furnishedfor intern quarters. The entire complexhas increased the University's previousclinical research facilities by about 20per cent. SWEDISH MEDICAL STUDENTSVISIT THE CLINICSForty-four Swedish medical studentsfrom the University of Goteborg, calling themselves the Society of RetractorHolders, paid a visit to the Universityin July. They and their professor, EinarLjunggren, were on a tour of the outstanding medical schools of the UnitedStates. Nels Strandjord '46 who madethe arrangements for their stay in Chicago, organized an itinerary that allowedthe visitors to meet with staff and students and to participate in the rounds ofclinics and lectures which make up atypical day for the Chicago student.They attended clinics and ward rounds,a cardiac conference, and a noon lecturegiven by Charles Huggins. They werealso guests of the Medical Alumni Association for lunch and for cokes in theafternoon with Chicago medical students.Later in the day, Dr. Strandjord gavethem a lecture on baseball (which theyseemed to find a greater test of imagination than any other lecture that day)and they finished the day at the WhiteSox Ball Park as the guests of the management.In token of appreciation for their experience at Chicago, they named theirhosts Honorary Fellows of the Societyof Retractor Holders.STUDENT AFFAIRSCOMMITTEE DISCUSSESCURRICULARepresentatives from twenty midwest medical schools assembled at TheUniversity of Chicago in June for theannual Midwest Regional Meeting ofthe Continuing Group on Student Affairs of the Association of AmericanMedical Colleges. The group, composedof those representatives primarily concerned with medical student matters,met with premedical advisors fromnine colleges to discuss changes incurricula in undergraduate schools andtheir effect on the preparation ofmedical school applicants. Other topicson the agenda were financial aid tostudents and possible changes in datesfor medical school acceptances. Reportswere made on unique programs initiatedby several midwestern schools in recent years.Joseph Ceithaml, dean of studentsin the division of the biological sciences,was chairman.MEDICAL ALUMNI BULLETIN 19D.S.A.June 6 was a doubly important nightfor Egbert H. Fell, '31, presented forthe DSA by William E. Adams, forhis son, Thomas E. Fell, is a memberof the 1963 graduating class. The seniorDr. Fell is an attending surgeon at CookCounty and Presbyterian-St. Luke'shospitals and a clinical professor ofsurgery at the University of Illinois.He took his internship and residencytraining at Presbyterian Hospital and aresidency at Municipal ContagiousDisease Hospital in Chicago. During thewar he served with the PresbyterianHospital Unit in the Pacific theater,both in New Guinea and the Phillipines.The first University of ChicagoMedical School (south side) graduate tobe elected to the American SurgicalAssociation, Dr. Fell is also a memberof the American Association for ThoracicSurgery. He is the current presidentof the Chicago Surgical Society.Dr. Fell worked with the late Dr.20 M E Die A L A l U M NIB U L LET I N REUNIONBenjamin Gazul at Cook County Hospital and together they were responsiblefor reorganizing and developing thepediatric cardiology unit there into oneof the finest in the world. The groupof doctors working in this unit haveproduced an impressive series of studieson the clinical aspects of congentialheart disease.Dr. Fell has been a valued memberof the Alumni Council for many years,working closely with the officers of theorganization.Edwin M. Miller, Rush '13, wasthe second DSA recipient to make Reunion night a family affair. Mrs. Miller,his son Dean, '56 and his wife, andmembers of the Rush '13 class celebrating their fiftieth anniversary werepresent to hear John Van Prohaska,'34 introduce Dr. Miller and to applaud when he received his award.Dr. Miller is emeritus clinical professor of surgery at the University ofIllinois (Rush) and consulting surgeon at Presbyterian-St. Luke's Hospital. Following internships at Presbyterianand Cook County Hospitals, he joinedthe faculty of Rush Medical Collegeand the staff of Presbyterian in 1915.In 1916 he was appointed Nicholas SennFellow in surgery under Dallas B.Phemister. He served in both WorldWars, with the medical corps in Franceduring the first and as chief of surgeryat General Hospital No. 13 in NewGuinea during the second. Dr. Millerwas vice-president of the medical staffof Presbyterian Hospital from 1947-53 and chairman of its department ofsurgery from 1949-1954.As a young intern, Dr. Miller tookpart in experimental work conducted atPresbyterian Hospital in the development of the electrocardiograph machine.His many publications, while primarilyrelating to problems of surgery inchildren, include articles on physiology,experimental surgery, injuries to peripheral nerves, and varied clinical problemsin general surgery.Active in numerous surgical societies,Dr. Miller is a member of the AmericanSurgical Association and has served asvice-president, treasurer, and presidentof the Chicago Surgical Society.Theodore B. Rasmussen, faculty1947-54, was presented by Joseph P.Evans. Dr. Rasmussen received his B.S.,M.D., and M.S. degrees from theUniversity of Minnesota where hisfather, A. T. Rasmussen, was professorof neurological anatomy. Following atwo-year surgical internship at KingsCounty Hospital, he trained at theMontreal Neurological Institute and theMayo Clinic before entering the UnitedStates Army in 1942 where he servedas a neurosurgeon for the FourteenthEvacuation Hospital. Upon his separation from the Army, Dr. Rasmussenreturned in 1946 to the staff of theMontreal Neurological Institute andthe faculty of McGill University, butleft the following year to become headof neurological surgery at The University of Chicago.While in Chicago he continued workbegun in Montreal on the problems of convulsive seizures and, in collaborationwith Paul V. Harper, began importantresearch on the use of Yttrium''? forthe destruction of the pituitary gland inan effort to arrest the ravages ofmetastatic _cancer.Dr. Rasmussen left the University in1954 to accept the post of professor ofneurology and neurological surgery atMcGill, and in 1960 assumed the Directorship of the Montreal NeurologicalInstitute. In concluding his introduction,Dr. Evans remarked: "... here is thatunusual academic jewel, an excellentand clear-sighted teacher, a skilled investigator of great integrity, a goodadministrator, and above all a compassionate physican."In presenting Robert Rushmer, '35,M. D., Rush '39, Peter Moulder, '45,delighted his audience by describing Dr.Rushmer as "the Charlie Huggins of theWest." He observed that Dr. Rushmer"has developed biophysical and physiological techniques to the point wherehe studies virtually all the important parameters of the circulation simultaneously and continuously .... "Dr. Rushmer, who served his internship at St. Luke's hospital in SanFrancisco and held a two-year fellowship at the Mayo Clinic, joined thefaculty of the University of Washington in Seattle in 1947 and has been aprofessor in its department of physiologyand biophysics since 1956. His numerous publications in physiology, biophysics, and cardiovascular researchhave won him many honors, amongthem the Ida Gould Award.In speaking of Dr. Rushmer's achievements, Dr. Moulder said, "He is so farahead of us in cardiovascular physiologythat he is not even competition." He haspioneered in coordinating the research ofneuro- and cardiovascular physiologistson the central nervous system controlof circulation and has led the way indeveloping the use of biomedical engineering instruments to increase thecoordination of research in all theareas of the biophysical sciences as theyrelate to cardiovascular physiology.ME Die A L A L U M NIB U L LET I N 21KELSEYKEYFrances Oldham Kelsey, Ph.D., '38M.D., '50, was awarded the Gold Keyof the Medical Alumni Association. Dr.Kelsey was a member of the pharmacology staff from 1946 to 1952 and wasintroduced by her former colleague,Lloyd J. Roth, '52, now chairman ofthat department.Dr. Kelsey, who was recently appointed chief of the Investigational DrugBranch of the Federal Food and DrugAdministration, achieved internationalrecognition last year when her role inthe prevention of a thalidomide tragedyin this country was revealed. The 1962Kefauver-Harris Amendments of theFederal Food, Drug and Cosmetic Actof 1938 were in large part a result ofthe thalidomide experience.In her Banquet speech, "Chicago andthe New Drug Legislation," Dr. Kelseysaid that her own caution in refusingto approve thalidomide for marketingin the United States was partly due toher participation, while a student atChicago, in the "sulfanilimide elixir" research which precipitated the 1938 law.The "sulfanilimide elixir" had causedthe death of at least 100 persons, most22 M E 0 I CAL A L U M NIB U L LET I N of them young children; Eugene M. K.Geiling and Paul R. Cannon, '25 ledextensive research on this substance andestablished that the cause of death wasa poisonous chemical, diethylene glycol,used as a solvent in the -elixir. "The urgency of the situation, the intensiveround-the-clock toxicologic studies, andthe subsequent changes in the law relative to the control of drugs could notand did not fail to make a deep impression on a graduate student such as myself in this University's Department ofPharmacology," said Dr. Kelsey.She pointed out that the influence ofthe University and the city of Chicagoon new drug legislation date back to1906, when Upton Sinclair's book, TheJungle, with its descriptions of unsanitary methods in the Chicago meat packing industry, brought about the changein public opinion which resulted in thefirst Pure Food and Drug Law. Sinclairgot his background for the book, shenoted, living "back of the yards" andboarding at the University SettlementHouse, then headed by Mary McDowell.In describing the source of her concern over the possible effects of drugson unborn .infants she referred to research in which she took part at theUniversity in 1944. Animal experimentswith quinine oxidase, an enzyme thatacts on quinine, showed that the enzymewas found in the animal's liver shortlyafter birth, but not before then. Studiesby other scientists since then have shownthat unborn and new-born infants lacka number of drug-metabolizing enzymes,and in consequence are particularly susceptible to drugs given to the mother inpregnancy, or the child in infancy.Dr. Kelsey said that the new amendments to the Federal Food, Drug andCosmetic law "are designed to eliminateall unnecessary risks to the public thatmay arise in the development of newdrugs.""Fears have been expressed that theincreased governmental control will havean undesirable effect on the developmentof new drugs," she said. "It should bepointed out, however, that similar fearswere expressed concerning the new drugprovisions of the Federal Food, Drugand Cosmetic Act of 1938."Despite this, the intervening yearshave shown great progress in the development of new drugs. It is to be hopedthat the new regulations will result inimproved procedures for the preclinicaland clinical evaluation of the safety andeffectiveness of new drugs without disturbing the pattern of sound scientificresearch and development." SENIOR HONORS ANDAWARDSFour members of the Class of 1963were graduated with honors. They were:Ira Finegold, John Schneider, MarvinStone, and Robert Woodson.James Esterly won the Borden Awardfor his paper on "Increased ArterialPermeability in Hypertensive Rats."Work on this study was done in theDepartment of Pathology.The Medical Alumni Prize for excellence in the delivery of a paper atthe Senior Scientific Session was awarded to John Schneider, who presented areport on "In Vitro Cysteine Synthesisin Rat Liver Mitochondria." Honorablemention was given to Harvey Wolinsky,for his presentation of a paper on"Functional Implications of the Composition and Architecture of the RabbitAorta."The graduating class this yearincluded two winners of the SheardSanford Award of the American Societyof Clinical Pathologists. Dr. HaroldD. Palmer, president of the society,said that it was extremely unusual fortwo students at the same medical schoolto receive the award; only ten are givenacross the nation each year. Thosehonored were Ira Finegold, for hisresearch on "Transplant Immunityand Immunological Enhancement," andRoger Ladda, for his report on "Experimental Lead Poisoning: Light andElectron Microscopic Study of Changesin Renal and Hematopoietic Tissues."Dr. Palmer noted that the researchcommittee was also impressed withMarvin Stone's paper on "CombinedInhibitory Effect of Antitumor Antibody and an Oncolytic Virus on theSolid Ehrlich Tumor."Thomas A. Borden received theAmerican Society of Clinical Pathologists-Bausch & Lomb Award goldmedal for his report on "A PhysicoChemical Study of the LipoproteinSystem of the Normal and EstrogenTreated Male Rat in Relation toAtherosclerosis. "Barry Kahan, a junior, was awardedthe Harry Ginsburg Memorial Prize inphysiology for 1962-63.Michael Kinney was chosen by hisclassmates to make the speech for theSeniors at the Banquet.WESTABY, KUHNS, McREYNOlDS, RINDER, NADEAU, and SUTCHTHE CLASS OF 1913Early this spring we requested members of the class graduated from RushMedical College in 1913 to send us information on their careers and currentoccupations. Nineteen of the thirty-eightliving members responded, and we sentcopies of this biographical informationto all of their classmates. The materialproved so interesting that we regret thelack of space which prevents us fromreporting it in full.As usual, more than half of those whowrote in are still engaged, at least parttime, in the teaching or practice of medicine. They would probably agree withtheir classmate Franklin Nuzum, whobelieves that "one wears out much moreslowly than he rusts out." Life is notstanding still for those in retirement,either, if Oscar Nadeau is representative. In 1955 Dr. Nadeau and his wife(also a surgeon) took their yacht downthe Illinois and Mississippi Rivers andthrough the Gulf of Mexico to their newhome just outside Fort Lauderdale,where they now operate a 240-acre farmand orange grove.The careers of these men are the bestsort of memorial to their alma mater.Some, like that of George L. Rathbun,whose family has given over 100 yearsof continuous service in the Knox Countyarea of Illinois, exemplify a long-standing ideal of medical service to the community. The career of Dennis E. Jackson, who in 1915 invented the closedsystem of anesthesia, demonstrates another method of service-research.Louis W. Sauer, obliged to give up practice in 1959 because of arthritis,currently spends three mornings a weekin the University of Miami School ofMedicine, working with residents, interns, and Cuban refugee physicians whowant to become pediatricians. Teaching,healing and exploring the frontiers ofmedicine, the men and women of theclass of 1913 are an inspiration to thosewho follow them. We salute both theiraccomplishments and their continuedand heartening vitality.Seven members of the class joined usfor their fiftieth anniversary. Testimonials commemorating the occasion werepresented to:Ralph H. Kuhns, attending physicianwith the Cook County Mental HealthCommission and a consulting psychiatrist for the Hilton Hotels Corporation;Ralph McReynolds, in active practiceof internal medicine in Quincy, Illinoissince 1920;Edwin M. Miller, clinical professoremeritus of surgery, University ofIllinois;Oscar E. Nadeau, retired from thepractice of surgery in Fort Lauderdale,Florida;Carl O. Rinder, in active practice ofinternal medicine. Dr. Rinder is on theconsulting staff of Presbyterian-St. LukesHospital;Yorke B. Sutch, retired from generalpractice in Boca Raton, Florida;John R. Westaby, in general practice in Madison, South Dakota, since1919. Testimonials were sent to:Hugh E. Cooper, Peoria, Ill.John D. Fowler, Los Angeles, Calif.Lillian E. Fowler, Vancouver, B.C.David Greer, Houston, Texas.Edwin S. Hamilton, Kankakee, Ill.Henry J. Heusinkveld, Clinton, Iowa.Dennis E. Jackson, Cincinnati, Ohio.Edward D. LeCompte, Salt LakeCity.Frank F. Maple, Chicago.Joseph L. Martineau, St. Paul, Minn.Linn F. McBride, Evanston, Ill.Edwin P. McLean, Brownsville,Texas.Harry P. Merrill, Los Angeles.Virgil H. Moon, Coral Gables, Fla.Herbert J. Movius, Los Angeles.Franklin R. Nuzum, Santa Barbara,Calif.George L. Rathbun, New Windsor,Ill.Fayette B. Ross, Whittier, Calif.Louis W. Sauer, Coral Gables, Fla.E. Vernon Sheafe, Seattle.Arthur L. Smith, Lincoln, Nebr.James G. Ware, Hauula, Oahu,Hawaii.BARLOWMcCLINTOCK AWARDThe Class of 1963 chose Charles F.Barlow, '47, as the recipient of thefive-hundred dollar McClintock Awardfor outstanding teaching. He returnedfrom a house-hunting expedition inBoston to receive the award and by nowis established in his new position asBronson Crothers Professor of Neurology at Harvard.M E 0 I CAL A L U M N I 8 U L LET I N 23Officers of Medical Alumni1963-64President Emmet B. Bay, B.S. '20,M.D., Rush, '22, joined the faculty ofRush in 1924 and the staff of The Clinicsin 1927. He was, in fact, the first personto practice medicine in The Clinics-inthe summer of '27 before they were officially opened. He is a professor in thedepartment of medicine and head of thesection on cardiology.Vida B. Wentz, S.M. '27, M.D., '35,our Vice-President, is on the faculty ofNorthwestern Medical School and an attending pediatrician at Children's Memorial and Wesley Memorial Hospitals.Richard J. Jones, Secretary, took his24 M E Die A L A L U M NIB U L LET I N BAYM.D. degree at the University of Buffaloin 1943. He came to the University ofChicago for his internship and residencyand is an associate professor of medicinein the cardiology section.John Doull, Ph.D., '50, M.D., '53,is Treasurer of the Association. He isassociate professor in the department ofpharmacology and the assistant directorof the USAF Radiation Laboratory.Two alumni were elected to three-yearterms on the council:Wynn Sayman, '53, assistant professor in the department of surgery.Robert L. Schmitz, '38, associateclinical professor of surgery at LoyolaUniversity. He is senior surgeon at MercyHospital in Chicago and attending surgeon at Cook County Hospital. ALL IN THE FAMILYThe Medical School of The Universityof Chicago is almost a family institutionfor several members of the 1963 graduating class. Dirk DeYoung and ThomasFell are sons of '32 classmates VernonDeYoung and Egbert Fell, and William Gernon follows his father, JohnH. Gernon, Rush '19. Brian Gallagher'Sfather, Thomas F. Gallagher, receivedhis Ph.D. in biochemistry here in 1931and remained in that department as amember of the faculty until 194 7; Brian'sbrother, Tom, Jr., '62, is a resident inmedicine. In addition, George Bray hasa brother, Robert, who received his M.D.in '59, Paul Hoffer follows Mark, '60,and Selwyn Rose's brother, Norman,was a 1957 graduate.HUGGINS HONOREDCharles B. Huggins has been awarded the 1963 Albert Lasker MedicalResearch Award-the highest honor ofits kind in this country. He shares theaward for clinical research withMichael E. DeBakey of Baylor University.Dr. Huggins, now director of BenMay Laboratory, was honored for discoveries leading to the "first temporaryhormonal control of human cancer."From his laboratories came the nowclassic treatment for cancer of theprostate by administration of femalesex hormones or removal of the malesex glands, a form of therapy whichgave the first proof of the effectivenessof hormones against cancer in man. Inaddition, Dr. Huggins developed awidely used procedure for surgical removal of the adrenal glands in faradvanced cancer of the breast.In his lecture at the award ceremony, Dr. Huggins described the progress of his therapeutic techniques anddiscussed a new procedure, still in theexperimental stage, which uses twofemale hormones-estradiol benzoate andprogesterone-for the treatment of advanced breast cancer.In a 1962 Medical Alumni Day lecture, Dr. Huggins reported that he was"busy and happy in the lab." It is wellfor us all that he is.KOCH MEDALDwight J. Ingle, professor and chairman of the Department of Physiology,was awarded the Koch Medal at theannual meeting of The Endocrine Society in June. The Fred Conrad KochMemorial Fund award, the highesthonor of The Endocrine Society, isgiven annually for work of special distinction in endocrinology. Dr. C. N.H. Long, who presented the medal,praised Dr. Ingle's contributions to thefield, adding that he thought the honorappropriate "also because you are anarticulate and eloquent interpreter ofthe role of science in men's affairs."Dr. Ingle is editor of the journal,Perspectives in Biology and Medicine,and author of two books: Principles ofResearch in Biology and Medicine, andhis autobiography, I Went to See theElephant. He is past president of TheEndocrine Society and a member ofthe National Academy of Sciences. ABRAHAM FLEXNER AWARDVice-president Lowell T. Coggeshall, Dean of the Division of theBiological Sciences from 1947-60, wasawarded the 1963 Abraham FlexnerAward for Distinguished Service toMedical Education by the Associationof American Medical Colleges. Dr.Coggeshall, who is well-known for hisinvestigations of tropical diseases aswell as for his career as an administrator, was cited "for his contributionstoward providing better facilities forthe pursuit of medicine as a scienceand for the high standards of excellencethat he has demanded of medical education."In 1956 Dr. Coggeshall served asSpecial Assistant for Health and Medical Affairs to the Secretary of theDepartment of Health, Education andWelfare. Working in 1957 as a member of the Secretary's ConsultantsCommittee on Medical Research andEducation, he was instrumental inshaping the policy of the federal government and of universities in the field ofmedical education and research. Withreference to these and related activitiesthe AAMC citation noted: "It is fittingthat this a ward should go to a manwho has played a more than ordinaryrole in the direction of policy relatingto medical education -both it his ownUniversity and at the national level."Dr. Coggeshall is Frederick H. Rawson Professor of Medicine in theUniversity.OUR MEN IN THE WHITEHOUSEWe were happy to note that thelist of twenty-six books selected forthe medicine and public health sectionof the White House library includestwo volumes by Benjamin Rush: hisAutobiography and Letters. We feelthat the spirit of the founder of Rushis part of the heritage of this medicalschool, and we are proud to see hislife and work commemorated.Also included on the list is' A History of the American Medical Association, by Morris Fishbein, Rush '12,professor emeritus of the University ofChicago. Dr. Fishbein received the University of Chicago Alumni Medal lastyear. NOBEL PRIZEMrs. Maria Goeppert Mayer (Enrico Fermi Institute for Nuclear Studies1946-60) has been awarded the NobelPrize for her model of nuclear shellstructure. Her classic paper in PhysicalReview ( 1949) describes the arrangement of the protons and neutrons inside the nucleus as a system of shells,similar in structure to that of theelectrons in the larger atoms. Eachshell of orbit corresponds to a specificlevel of energy, and a nuclear particlecan pass from one to another only byan abrupt "quantum jump."Professor J. Hans D. Jensen of theUniversity of Heidelberg, with whomMrs. Mayer shares the prize, had arrived at the same conclusions independently; he published an identicaltheory in the same issue of PhysicalReview. In 1955 the two scientists collaborated on Elementary Theory ofNuclear Shell Structure, in which theyexplained their theoretical model andits further development by others.Mrs. Mayer is now a professor atthe University of California at LaJolla.PSYCHIATRISTS MEETThe Institute on Training in Community Psychiatry, sponsored jointlyby the Department of Psychiatry ofThe University of Chicago and theTraining Branch of the National Institute of Mental Health, held its firstmeeting October 9 through 12 in Chicago. Three similar regional meetingswill be held later this year in SanFrancisco, New York City, and Dallas.Robert S. Daniels and Philip M.Margolis, both associate professors ofpsychiatry at the University, were cochairmen of the Institute.They reported that, "A growing number of psychiatrists are serving eitherfull- or part-time as advisors andconsultants on mental health to community agencies."The aim of this program is to findways to interest and train other youngpsychiatrists, during their psychiatricresidency, in this kind of broadercommunity service."Specialists in psychiatric trainingand a selected group of psychiatricresidents from teaching institutions inthe District of Columbia and ten statesparticipated in the meeting.M E 0 I CAL A L U M NIB U L LET I N 25GRADUATE NEWS II������_F_A_C_U�L_T_Y_N�E_W_S������'37. Clinton L. Compere is vice-presidentof The Rehabilitation Institute of Chicago.'40. Randall L. Thompson has becomespecial assistant to the associate directorfor collaborative research at the NationalInstitute of Allergy and Infectious Diseases.'43. Stanford K. Sweany has been electedpresident of the Illinois chapter of theAmerican College of Chest Physicians.'45. Harry W. Fischer has been namedfull professor and head of the section ofdiagnostic radiology at the State Universityof Iowa College of Medicine.'48. Charles J. Buhrow is currently medical director and chief of the departmentof radiology at the U.S.P .H.S. Hospital inDetroit.'51. William M. Smith is now chief ofthe department of medicine at the U.S.P.H.S.Hospital in San Francisco.'53. Marvin S. Weinreb is clinical instructor of dermatology at the Universityof California Medical School and has a private practice in Hayward. He reports thathe is "very happy."'54. Daniel Levinson is a fellow withthe medical-psychiatric liaison group at theUniversity of Rochester Medical Center.He plans to return to general practice inSeattle.'55. William C. Dement is now associateprofessor of psychiatry at Stanford University.Edward L. S. Jim recently became adiplomate of the American Board of Surgeryafter completing postgraduate training incancer surgery at Memorial Hospital forCancer in New York. He is now beginningprivate practice in Honolulu, where hisbrothers, Vernon K. S. Jim, '44, andRobert T. S. Jim, '48, are practicing physicians.R. Weinreb reports: "After much traveling (Japan for military service, first year ofresidency in dermatology at MassachusettsGeneral Hospital and second year as a preceptee in Philadelphia), we have finallysettled down to a normal third year ofresidency in dermatology at the UniversityHospital of Pennsylvania."'57. Harvey L. Lerner has recently begunprivate practice in Hauppauge, New York.'60. Donald Comiter is now in urologyresidency at Jefferson Hospital in Philadelphia. He is married and has two daughters.'61. Robert L. Anderson, having attended the Naval School of Aviation, is nowstationed at Barber's Point, Honolulu, forthree years.George E. Tagatz has just completedhis first year of residency in internal medicine at University Hospitals of Cleveland.He will spend the next two or three yearsin the Army, starting with thirteen monthsin Korea.Robert W. Woodward has recently accepted the position of Harvard TeachingFellow and second year resident in obstetricsand gynecology at the Beth Israel Hospitalin Boston.'62. J. R. Eckerly is now a resident ininternal medicine at Minneapolis GeneralHospital.26 M E Die A L A L U M NIB U L LET I N William E. Adams gave the Louis E.Schmidt Memorial Lecture at the annualmeeting of the North Central Section of theAmerican Urological Association in Chicagoon September 13. He spoke on "Observationon the Teaching and Practice of Urologyand Other Medical Sciences in the Middleand Far East."John Arnold, '46, has left The Clinicsto become professor of medicine at the University of Missouri and Chief of Medicineat the Kansas City General Hospital.President George Wells Beadle hasbeen elected to the American Academy ofArts and Sciences.H. Stanley Bennett has been selectedfor a "term of four years on the newly established National Advisory Research Resources Committee.Paul C. Buey ('28-'41) is now honorarypresident of the World Federation of Neurosurgical Societies.Benjamin Burrows and Charles M.Fletcher of the Postgraduate Medical Schoolof London reported on a comparative studyof American emphysema and British bronchitis at the annual meeting of the AmericanThoracic Society in June. They told themeeting that "the major difference (betweenthe two diseases) ... is a semantic one."Albert Dorfman, '44, has been electeda fellow of the American Academy of Pediatrics.C. Wesley Eisele ('34-'51) married Jessica Barnard Moore, M.D., on September 1.Robert J. Hasterlik, Rush '38, reportedfindings of the Niles leukemia study groupat an open forum on the Niles leukemiainvestigations in August. Dr. Hasterlik saidthat there was "no common factor" to explain the high incidence of leukemia in theparish of St. John Brebeuf in Niles, Illinoisduring 1957-60. However, the cluster ofeight cases clearly constituted a "microepidemic," he said, suggesting a "relationshipto the infectious process." A detailed reporton the investigation, by Dr. Hasterlik andClark W. Heath, Jr., was recently publishedin the American Journal of Medicine.Paul C. Hodges, Professor Emeritus ofRadiology, has been accorded "The Cravatof the Order of Brilliant Star" in recognitionof his contributions to the organization anddevelopment of radiology in the TaiwanVeterans General Hospital. This is the highest civilian honor awarded by the government of Taiwan.Clay G. Huff ('30-'47), former professorof parisitology here, is now president of theAmerican Society of Tropical Medicine andHygiene. Since 1947 Dr. Huff has headedthe Division of Parisitology at the NavalMedical Research Unit in Bethesda.Leon O. Jacobson, '39, has been givena special award by the American NuclearSociety for research on the biological effectsof radiation. Dr. Jacobson, who was honoredchiefly for his work in determining the roleof the spleen in preventing and repairingradiation damage, is the first recipient ofthe award for Distinguished Service in theAdvancement of Nuclear Science. Dr. Jacobson was also recently appointedto the National Cancer Institute's Boardof Scientific Counselors.H. P. Jenkins, '27, John Van Prohaska,'33, and Peter V. Moulder, '45, participatedin a meeting of the International Societyfor Surgery in Rome in September. Laterin the month Dr. Moulder also attended theFirst International Congress on HyperbaricOxygen Therapy in Amsterdam.Elwood Jensen, cited as an "inquirerinto the chemistry of cancer and therebya contributor to the healing of mankind,"was awarded an honorary doctor of sciencedegree by Wittenberg University.Lloyd Kozloff, professor of biochemistry,has accepted an appointment at the University of Colorado Medical Center as professorof microbiology beginning July 1. He hasbeen at the La Jolla branch of the University of California this year as visiting research fellow.John Lindsay made a journey last Aprilto Taipei, where he worked with Paul C.Hodges, professor emeritus of radiology.While abroad he took part in the meetingof the Barany Society, delivered the openinglecture at the First British Academic Conference in Otolaryngology, and received anhonorary doctorate from the University ofUppsala, Sweden.Clayton G. Loosli ('38-'58), Ph.D. '34,M.D. '37, has asked to be relieved of hisduties as dean of the University of SouthernCalifornia School of Medicine in order toassume the position of medical director ofthe U.S.C.-affiliated Hastings Foundation.Dr. Loosli will remain on the U.S.C. facultyas professor of medicine.Norman Siderius, instructor and chiefresident in the department of surgery, joinedthe armed services on July 1.David W. Talmage ('52-'59), now professor and chairman of the Department ofMicrobiology at the University of Colorado,is director of a clinical research programinvolving promising new studies on transplantation of vital human organs. Continuedfederal support of the program is assuredby a grant from the National Institute ofAllergy and Infectious Diseases.Ilza Veith will leave The Clinics in January to become professor of the history ofmedicine in the Department of MedicalHistory and Bibliography at the Universityof California Medical Center in San Francisco. Dr. Veith spent two weeks this fallas Sloan Visiting Professor at the MenningerFoundation.Birgit Vennesland, Ph.D., has won theAmerican Chemical Society's Garven Medalfor her distinguished services to chemistry.Dr. Vennesland's research has been largelydevoted to the part played by carbon dioxidein the life processes of animal tissues and therole of carbon dioxide and oxygen in photosynthesis. She was among the first to useradioactive carbon to trace reactions in livingsystems.,--_R_U_S_H_N_E_WS_ ___,II RES IDE N T NEW 5'13. Ralph H. Kuhns has been elected alife member of the American PsychiatricAssociation.'21. J. Arnold Bargen is director .ofmedical education at the Scott and WhiteMemorial Hospital and the Scott, Sherwoodand Brindley Foundation. He is also chairman of the A.M.A. Council on ScientificAssembly and president of the InterstatePostgraduate Medical Association of NorthAmerica for 1963-64.'26. Angus C. McDonald was installedin Mayas treasurer of the Board of Trustees of California Physicians' Service--BlueShield.'30. Leonidas H. Berry was the guestlast May of former classmate Henry N.Harkins, chairman of the department ofsurgery at the University of Washington.Dr. Berry is one of the nation's leadingdiagnosticians of stomach disorders. Hepresented two days of lectures and discussioncentering around the use of the gastroscopeto students, faculty and house staff at theUniversity of Washington.'31. Ying Tak Chan is now a staff member of the Maternal and Child Health Bureau of the District of Columbia PublicHealth Department.'32. Lewis B. Newman received theGold Key award of the American Congressof Physical Medicine and Rehabilitation inrecognition of his outstanding contributionsin teaching, writing and research.'35. Dan L. Urschel, cardiologist of Mentone, Indiana, is now president of the Flying Physicians Association.'36. Zachary Felsher, assistant professorof dermatology at Northwestern receivedfirst prize in the annual contest of the Chicago Dermatological Society for "Studieson the Rings of Henle in Skin."'37. Henry Lederer is now chairman ofthe Department of Psychiatry at the Medical College of Virginia.The 1964 reunion of the class of 1913 hasbeen scheduled for June 4th at the ChicagoAthletic Club.BULLETINof the Alumni AssociationThe University of ChicagoSCHOOL OF MEDICINE950 East Fifty-ninth Street, Chicago 37, IllinoisVOL. 19 AUTUMN 1963 NO.2EDITORIAL BOARDJESSIE BURNS MACLEAN, SecretaryARCHIE LIEBERMAN, Art EditorWRIGHT ADAMS ROBERT J. HASTERLIKJOHN D. ARNOLD ELEANOR M. HUMPHREYSL. T. COGGESHALL HUBERTA LIVINGSTONERICHARD EVANS PETER V. MOULDERWALTER L. PALMER Chief residents in Billings 1963-64:Medicine--Duane Taehel, '60Neurosurgery-Javad Hekmatpanah,Madresseh Teb, '56Obstetrics-Gynecology-Yves Lefebvre,Montreal, '58Ophthalmology-Marcel Frenkel, '58Pediatrics-Priscilla Kao, Columbia, '60Psychiatry-Gerald Cohen, ChicagoMedical School, '60Surgery-John Benfield, '55Thoracic Surgery-James Rams, Georgetown, '55David G. Cogan ('32-'33), Harvard, '32,has been elected Henry Willard WilliamsProfessor of Ophthalmology at HarvardMedical School.Nathaniel D. Greenberg ('59-'62), Harvard, '56, has begun the private practice ofinternal medicine in Chicago.Arthur S. Keats, M.D. '46., University ofPennsylvania, ('46-'47), chairman of theDepartment of Anesthesiology at BaylorUniversity, recently synthesized a nonaddictive analgesic drug (WIN 20,228) as potentas morphine.Harwell Wilson, M.D. '32, VanderbiltUniversity, ('32-'39), has been installed astreasurer of the American College of Surgeons and president of the South East Surgical Congress for 1963-64.DEATHS'94. Joseph Prendergast, Oak Park, IlL,March 26, age 96.'95. Nels C. Meling, Chicago, February22, age 91.'00. William Healy, Clearwater Beach,.Fla., March 15, age 93.John E. Smith, Clarence, Iowa, July 6,age 89.'01. Oscar Cleff, St. Petersburg, Fla., November 15, 1962, age 85.Herbert G. Vaughan, Norton, Mass.,May 16, age 88.'03. Frederick J. Corey, Havana, Ill.,May 3, age 85.Emil F. Tholen, Beverly Hills, Calif.,March 11, age 83.Otillie Zelezny-Baumrucker, Cicero, Ill.,October 3, age 83.'07. George Enos Miller, Rapid City,Mich., May 8, age 81.'08. William C. Nichols, Anaheim, Calif.,July 11, age 82.William C. Speidel, Seattle, Wash., June17, age 80.'09. Oswald G. Stark, Chicago, April 1,age 78.Edgar L. White, Lewiston, Idaho, May20, age 80.'11. Russell C. Doolittle, ClearwaterBeach, Fla., August 27, age 77.Arthur R. Metz, Chicago, IlL, June 15,age 76.'13. George H. Coleman, Chicago, June8, age 79. '14. Robert W. Kispert, Green Bay,Wise., June 13, age 71.'17. Hugh M. Fogo, Harrison, Ark.,April 27, age 76.Capt. Samuel A. Fuqua, La Habra, Calif.,June 2, age 74.'18. John M. Simkin, San Leandro, Calif.,January 15, 1962, age 67.'19. Vito A. D. Taglia, Oak Park, Ill.,May 3, 1957, age 60.James L. Williams, Evanston, Ill., J anuary 30, age 72.'20. Theophil P. Grauer, Chicago, September 26, age 66.Floyd H. Rush, Pittsburg, Kansas, May 4,age 68.'21. Francis R. Conroy, Ogden, Utah,April 4, 1962, age 69 ..Daniel W. Wheeler, Duluth, Minn.,April 8, age 68.'22. Donald W. Johnson, Los Angeles,Calif., July 22, 1962, age 65.'23. John M .. Radzinski, Chicago, Ill.,August 12, age 62.Charlotte B. Wiedemer, Cincinnati,Ohio, February 14, age 71.'24. Frank J. Costa, San Pedro, Calif.,March 29, age 64.Edgar C. Turner, Evanston, Ill., April 14,age 68.'25. Jacob J. Baratz, Chicago, Ill., March14, age 60.'27. Kate C. Constable, New York City,February 17, age 68.Howard M. Meyer, Kitchener, Ontario,Canada, May 10, age 68.'29. Julius Blumenstock, Danville, Ill.,May 23, age 64.Hugh A. McKinley, Cassopolis, Mich.,May 14, age 73.D. W. Thorup, Benton Harbor, Mich.,April 25, age 60.'30. George L. Perusse, Jr., Chicago, m.,April 10, 1962, age 59.'35. Edward S. Burge, Evanston, Ill.,June 11, age 53.Roy L. Johnson, Douglas, Georgia, May14, age 54.'36. Harold R. Ostrander, West Covina,Calif., August 28, 1962, age 52.Samuel Werner, Billings, Mont., December 29, 1962, age 53.'37. Herman A. Aageson, Oconto, Wise.,July 3, age 58.Warren B. Crane, Kalamazoo, Mich.,September 15, 1962, age 49.Irving Rose, Brooklyn, N.Y., June 23,age 52.'39. Joseph M. Plestina, Berwyn, Ill.,October 1, 1962, age 47.'41. Ralph W. Barris, Omaha, Neb., April13, age 57.'55. Robert Lundquist, Chicago, Ill., July2, age 35.'59. Thomas R. Thomas, Hammond,Ind., December 10, 1962, age 32.FACULTYWilliam A. Geer, Resident '36-'39, Stratford, Conn., April 18, age 55.Hugh Gestring, Resident '22, OverlandPark, Kansas, February 14, age 67.Stephen Rothman, '38-'59, 'professoremeritus, dermatology, Chicago, Ill., July 31,age 69.Gilbert Walter, Resident '56-'60, Chicago, October 26, age 39.Alvin Weiss, Resident '41-'42, Los Angeles, Calif., May 3, age 51.M E Die A l A l U M NIB U l LET I N 27