Volume 14 WINTER 1958 Number 2EXFOLIATIVE CYTOLOGY IN OBSTETRICS ANDGYNECOLOGYBy GEORGE L. WIED, M.D.Assistant Professor of Obstetrics and GynecologyThe cytological technique of cancerdetection has been known since the endof the nineteenth century. It gainedworld-wide publicity in 1887 when apathologist, von Bergman, diagnosed thepresence of carcinoma of the larynxfrom examination of the cells of thesputum of the German Emperor, Fried­rich III. The medical council of theEmperor did not believe that a diagnosisof carcinoma was possible from thisstudy of the sputum, especially as aminute biopsy did not show malignancy.The lesion remained undiagnosed and WIEDDr. Wied is a medical graduateof Charles University, Prague, in1945. In 1948 he became directorof cytology at the Free Universityof West Berlin. On a visit toGeorge N. Papanicolaou at Cornellin 1951 he made contacts whichled to his return in 1953 to join ourfaculty.He is the editor of the new jour­nal, Acta Cytologica, the officialperiodical of the InternationalAcademy of Gynecological Cytol­ogy. untreated until it progressed to an in­curable stage several months later andled to the death of the Emperor.The cytological examinations of sedi­ments of exudates were described asearly as 1908 in a monograph by Koeni­ger of J ena. Cytological technique didnot attain much publicity or acceptanceuntil 1943 when George N. Papanicolaouand Herbert F. Traut of Cornell Univer­sity Medical College introduced it as atechnique for the early diagnosis ofuterine carcinoma.Although cytologica l examinations of2 MEDICAL ALUMNI BULLETINALICE DARGAN, ALVINA KAKTINS, and CATHERINE KEEBLER in cytologylaboratory.exudates such as pleural or peritonealfluid, gastric and bronchial washings,sputum, breast secretions, prostatic se­cretions, and urine have been the sub­ject of more experimental and clinicaltrial within recent years, the originaland intensive interest remains within thearea of gynecological cancer detection.Screening for Cancer ofthe CervixExfoliative cytology for screening pa­tients for carcinoma of the uterine cer­vix has the following advantages:1) The diagnostic accuracy is higherthan 98%;2) The method may be applied rou­tinely as a general population screeningprocedure on apparently healthy indi­viduals;3) It may be anticipated, as docu­mented by Zinser, that one may detectone subclinical cervical carcinoma in theprocess of screening two hundred twen­ty apparently healthy women, within therange of usual variations according tothe type of patients; for example, Negropatients exhibit considerably higher in­cidence than Jewish women;4) The material for cytological exam­ination may be obtained during a rou­tine pelvic examination and does notcreate more problems or take moretime than the pelvic examination itself;5) The preparation of the smears isrelatively easy and does not need to bedone by a physician. Nurses or medicaltechnicians are able to prepare the speci­mens;6) The routine performance of punchbiopsies on the uterine cervix for cancer detection yields a less useful samplethan the cytological specimen, in addi­tion to being more complicated.Comparison with the other screeningtechniques for cervical carcinoma revealsa much greater efficiency for cytologicprocedure over visual examination withthe vaginal speculum and over colpos­copy by Hinselmann as depicted in thegraph in Figure 1. The advantage of ex­foliative cytology over all other pro­cedures of detection of cervical carci­noma is that the evaluation can be cen­tralized and does not necessitate anydiagnostic training on the part of theperson who sees the patient, whereas thecolposcopic examination, the Schillertest, the sound test, or routinely per­formed punch biopsies require specialtraining on the part of the immediateexaminer.When the high rate of pick-up and thediagnostic accuracy of 98% are con­sidered relative to the "curability" ofearly carcinoma of the uterine cervix,namely, practically complete curabilityfor Stage-O carcinomas and approximate­ly 72% for Stage-1 carcinomas as com­pared with the present over-all curabilityrate for cancer of the cervix of approxi­mately 31 %, such a routine screening isalmost imperative.Diagnostic errors ("false negative"readings) may occur if the cervical le­sion is extensive. Due to superficial cellnecrosis of the lesion, smears from ex­tensive carcinomatous lesions often ex­hibit no, or very few, well-preservedabnormal cells.Endometrial carcinomas are not aseasily or as accurately detected bymeans of exfoliative cytology. This is due to the facts that the specimens forroutine cytological examination are ob­tained from the vaginal wall, the uterinecervix, and the endocervix, but not fromthe intrauterine cavity, and that theglandular cells of the endometrium de­generate more rapidly than the squamousepi thelial cells of the ectocervix. Ovar­ian carcinomas could be occasionallydiagnosed in a relatively early stagefrom the cervical smears if the atypicalcells were carried through the tubes. Un­fortunately, an early diagnosis of ovar­ian carcinoma by this means of cellulartransport will remain the exception.Atypical cells shed from ovarian carci­noma are usually found when the lesionhas already caused the occurrence ofascitic fluid: the sediment of the peri­toneal fluid reveals then the atypicalcells with a rather high diagnostic accu­racy of over 80%.Exfoliative Cytology in Non­malignant DiseaseExfoliative cytology has usefulness inroutine diagnostic gynecologic studies inaddition to cancer screening, thus offer­ing a useful aid in practically every caseand not only for the patient with sub­clinical carcinoma.c8.90E�oo;:Ic ......u· .... ,.....j<IJ 8 ..O'os ......rFJx >-<IJ 0.00UCIJ0"0. .._ ......0U<IJ'56iiooSON�8�.... >--�uFIGURE 1S peculum examination of the uterine cer­vix will help to detect one clinically unsus­pected carcinoma in 1180 asymptomaticpatients.Colposcopy (Hinselmann) will help to de­tect one clinically unsuspected cervical carci­noma in 780 grossly normal cervices.Exfoliative cytology will help to detect oneclinically unsuspected cervical carcinoma in220 patients with grossly normal uterine cer­vices.MEDICAL ALUMNI BULLETIN 3Vaginal smear: Luteal phase1. Hormonal evaluationThe vaginal epithelium is more sensi­tive, and responds more rapidly to theaction of sex steroids than does the en­dometrium. Vaginal cytology may be re­peated many times, even daily, withoutany considerable discomfort to the pa­tient as would be the case with repeatedendometrial biopsies.In the hormonal evaluation of a pa­tient, exfoliative cytology is an economi­cal, sufficiently accurate technique forthe evaluation of ovarian function inpatients with sterility problems, menor­rhagia, metrorrhagia, amenorrhea, andhabitual abortion. The cytological tech­nique is useful in the determination ofthe effectiveness and duration of theeffect of administered estrogens, andro­gens, or progesterones.2. Microbiological classification ofthe vaginal floraExfoliative cytology can supplementbacteriological techniques. It will per­mit a rough microbiological classifica­tion which is usually sufficient for use inroutine obstetrical and gynecologicalpractice. In the detection of parasites,Cervical smear: Infection e.g., Trichomonas uaginalis , the fixedand stained cytological smear has ashigh or higher diagnostic accuracy thanthe conventional microscopic examina­tion of a fresh drop of vaginal fluid.Since patients complaining of leukorrheaconstitute a considerable portion of thegynecologist's routine practice, a suffi­ciently accura te microbiological classifi­cation of the vaginal flora is of practicaldiagnostic and therapeutic value.3. Identification of the site of a localinflammatory reaction in vagina,cervix, or endocervixAs there are always three smears(vaginal, cervical, endocervical) pre­pared on one glass slide, it is obviousthat a comparative evaluation of thepresence of inflammatory cell changes inthese three smears may lead to an iden­tification of possibly present inflamma-Cervical smear: Carcinomatory reactions into those which are ap­parently localized to either the vagina,cervix, or endocervix or those which areapparently diffuse. In this particularphase the cytological evaluation is madenot only from the actual inflammatorychanges of the epithelial cells, but alsofrom a comparative evaluation of thenumber of leucocytes, their state ofpreservation, and possible histiocytic re­action.With its acknowledged usefulness ofexfoliative cytology as the most accu­rate, efficient and practical technique ofcervical cancer detection, and with itsadditional applications in the diagnosisand surveillance of therapy of non­malignant diseases and disorders, exfoli­ative cytology represents the most use­ful and versatile laboratory technique inobstetrics and gynecology known at thistime. RESIDENT NEWSFelix Battat (Intern '55-'56) will be withthe Army for the next two years and looksforward to returning to Billings after that.He has finished a year of surgical residencyat St. Luke's Hospital in New York.William R. Bunge (Resident '44) is aMajor in the Army stationed at Ft. Myel',Virginia. He finds his Army service reward­ing and he is staying in.Crawford J. Campbell (Resident '46-'48)received a grant from the Orthopaedic Re­search and Education Foundation for workat Albany Medical College on "Injuries toEpiphyseal Plate in Dogs."Angelo P. Creticos (Resident '46-'47) ischief of clinical medicine of the Rehabilita­tion Institute of Chicago.Joseph G. Crotty (Intern, '33-'34) hasbeen elected Director of Obstetrics and Gyn­ecology at Good Samaritan Hospital in Cin­cinnati for two years. He was a FoundingFellow of the American College of Obstetricsand Gynecology.William F. Enneking (Resident '52-'56)received a grant from the Orthopaedic Foun­dation for work at the University of Missis­sippi Medical Center on "Histologic andImmunologic Investigation of HomogenousBone Transplants."Meyer S. Fox (Resident '35-'37) of Mil­waukee and Harold F. Schuknecht, '40,(Rush) spoke on "Occupational and Trau­matic Hearing Loss" at the joint meeting ofthe Chicago Laryngological and OtologicalSociety with the middle section of the Amer­ican Laryngological, Rhinological and Oto­logical Society in Chicago on January 14.Robert W. Harrison (Resident in Sur­gery) spoke on "Should a Collapsed (Ate­lectatic) Lung be Reaerated or Resected?"before the December 6th meeting of the Chi­cago Surgical Society.Eleanor W. Humphreys (Intern '55-'56)is a second-year resident in pathology atKennedy V.A. Hospital in Memphis.Richard A. Kredel (Resident '36-'37, '41-'42), president of the Los Angeles Radiologi­cal Society, will present an address on Feb­ruary 22 at the opening of the tenth annualmidwinter radiological conference sponsoredby that society.Raymond R. Lanier (Intern-faculty '44-'49) of the University of Colorado has beenawarded a contract for science research bythe U.S. Atomic Energy Commission.George Owen (Intern '56-'57) is at Ft.Ord, California.Robert M. Peck (Resident '51-'52) is inthe practice of internal medicine with agroup in Los Angeles. He has three children,Rachel, seven, Raphael, five, and Daniel,three.John A. Petry (Resident '51-'52) is inobstetrical-gynecological practice in FernCreek, Kentucky, just outside of Louisville.The Petrys have two children-Marcia,three, and Mark, one year old.Albert Van Ness (Resident '51-'57) isin private practice of internal medicine inBloomington, Illinois.Bruce Walls (Resident '52-'53) is nowdirector of the psychiatric residency trainingprogram at the University of Tennessee.4 MEDICAL ALUMNI BULLETINE. M. K. GElLING AND IARE OLD FRIENDS-We first met early in 1921 when hecame to work with Professor John J.Abel and to enter our second-year classin medicine at Hopkins. In those dayshe was lean (see photograph) and pro­vided with a shock of brownish hairwhich gleamed with copper tints in cer­tain lights. The problem which he un­dertook was concerned with the poste­rior pituitary and it was to this organ andits hormones that he devoted a largepart of the next fifteen years. In additionto holding down a practically full-timeresearch job, Geiling satisfied the re­quirements for the M.D. degree. Profes­sor Abel was delighted with his workand appointed him to a regular positionon the staff when he was graduated in1923. He was soon made responsible fora good share of the teaching of pharma­cology to the medical students.I next heard about Geiling in January,1926, when Professor Abel spoke beforethe Institute of Medicine in Chicago. Hedevoted most of the lecture to his workon the posterior pituitary and its effecton renal function. He brought his talkto a sudden and dramatic climax by tell­ing us that, with the indispensable helpof Dr. Geiling, he had just crystallizedinsulin.I did not see Geiling again until hecame to Chicago as Professor andChairman of the Department of Pharma­cology (1936). At that time he was moredeeply immersed in the problem of theposterior pituitary than ever and espe­cially bothered by the possibility of er­rors due to the extension of pars inter­media cells into the pars posterior. Forsome years he concentrated his effortson the problem of finding and studyingpituitary glands of those animals inwhich there was a clean anatomical sepa­ration of the anterior and posteriorlobes. This research sent him to thewhale fishing fleet off the coast of BritishColumbia for blue, sperm, finback andhumpback whales. After these huge ani­mals were killed many hours elapsedbefore the hypophysis could be dissected(or better, excavated). To check on thisdelay as a possible source of error, Geil­ing then went to the St. Lawrence wherethe beluga whales were caught commer­cially. As these are relatively smallwhales, the pituitaries were removedfrom them before autolysis had started.In Chicago he and his associates studiedthe pituitary of chickens and armadillos.In these animals, as in the whales, there GElLING in his radioactive gardenis a complete separation of the posteriorlobe from surrounding structures by con­nective tissue.I was able to help him and his stu­dents in the histological analysis ofthese glands. We soon became used toseeing Geiling appear with gallon jars ofenormous endocrine glands from whalesor sea cows. And then, the next we knewhe would be off to Florida where hewas studying living porpoises. Fromthese he obtained milk and all the vitalfluids as well as fresh endocrine glands(obtained from the anesthetized ani­mals) frozen for air transport to Chicagowhere chemical studies were then made.I shall skip hurriedly over this periodand omit recounting the difficulties whichDr. Geiling has accepted an ap­pointment as Visiting Professor ofPharmacology at the Universityof Rochester for the coming aca­demic year.This is conveniently close to hiscomfortable summer home in NewYork. His permanent address afterJuly 1 will be Post Office Box 292,Odessa, New York. His work onDr. Abel's biography will take himfrequently to Philadelphia andCleveland, and we hope to Chi­cago as well. had to be overcome before it was pos­sible for him to get the tissues from thewhales and porpoises. I also skip overthe hectic five years of war researcheswhen Geiling was the responsible investi­gator for the Toxicity Laboratory here;in addition, during this time he carriedon extensive studies on the chemother­apy of malaria.In the immediate post-war period Iremember distinctly his perseverance ingetting set up for the biosynthesis ofradioactively marked drugs of plant ori­gin (digitalis, morphine, colchicine, etc.).His aim of course was to use thesetagged drugs to help explain their sitesand modes of action. In this field hewas the real pioneer. Despite all thehandicaps of red tape and frequent dif­ficulties in obtaining the necessary appa­ratus, and, above all, against the dis­couraging advice of many scientists, hewas determined to get his radioactivefarm going. In the face of certain pessi­mistic calculations which led some toprophesy that Geiling could not getenough C14 into the drugs by exposingthe growing plants to C1402, he persistedand, as you know, he and his colleaguessucceeded magnificently in his endeavor:From these examples it is clear thathe is a biologist who has sought, withoutstanding success, those forms ofplant and animal life which would helpMEDICAL ALUMNI BULLETIN 5GElLING with DR. ABEL in the pharmacology laboratory at Johns Hopkins in 1921him solve the problems he had tackled.He has received great recognition in theworld of science and in our University,where he was made Frank P. Hixon Dis­tinguished Service Professor in 1941.He has given over twenty years ofservice to the Council on Drugs of theAmerican Medical Association. Thisactivity and his work as a consultant tothe Food and Drug Administrationhave given him comprehensive points ofview that have also contributed to hiswide knowledge of pharmacology. His broad scholarship plus his intense inter­est in his chosen field have made him adevoted teacher to both medical studentsand the advanced investigators whohave worked with him.He is now writing a Ii fe of his belovedProfessor Abel. This great and modestman, who did so much in the isolationof hormones and in the founding of bio­chemical and pharmacological science inthis country, always took special pleas­ure in following Geiling's work. I canstill see the gentle smile on the Profes- sor's face as he would nod approvinglyover something that Geiling had doneor said.As I look back over the years, when­ever I think of "Pete" Ceiling, the onecharacteristic that stands out is his ir­resistible forging ahead despite all obsta­cles to the solution of the importantand difficult problems which he was in­vestigating.WILLIAM BLOOM, M.D.Charles H. Swift Distinguished ServiceProfessor of Anatomy6 MEDICAL ALUMNI BULLETINA TRIBUTEgrno ).5. jIuckhardtINVESTIGA TOR, SCHOLAR, TEACHER, FRIENDBy LILLIAN EICHELBERGER, M.D.Associate Professor, Departments of Surgery (Orthopedics) and BiochemistryLUCKHARDTClimax came in the life of the late Dr.Arno B. Luckhardt on the winter morn­ing of January 21, 1923. On that "fair­not-cold" (Arno's diary) Sunday morn­ing thirty-five years ago three men metat Culver Hall, the University's physiol­ogy laboratory on Fifty-seventh Street.As Dr. Luckhardt lay down on a couchand extended his arm into the air, CarlDragstedt, a young intern who had had some experience administering anes­thesia, applied the mask. The tank fromwhich the gas issued was labelled, "Calc­rene." It was only 99% pure, havingbeen intended for use in garages as asubstitute for acetylene.Although the three men were familiarwith the effects of the gas on frogs,mice, cats, and dogs, one whiff by aman might mean eternity. The first pa- tient, however, survived the test withoutany effects except a pleasant nap, andother volunteers were recruited. Whilesome slept, their feet were slapped withwrenches and their arms were piercedwith "sterile safety pins," withoutawakening them.Such was one of the giant hours inthe annals of medicine-the discovery ofthe anesthetic properties of ethylene byDr. Luckhardt, Dr. J. Bailey Carter, andyoung Carl Dragstedt. At the time, anes­thesia was still primitive, generally ad­ministered by nurses. The discovery andintroduction of ethylene, which was thefirst advance in anesthesia since 1847,was the major agent in the developmentof the profession of anesthesiology, lead­ing to refinement of both the machinesand technicians.In addition to the world-wide honorDr. Luckhardt brought to the Universitywith his great discovery, he was a bornteacher. In his prime days of teachingphysiology, he had an elective course atseven o'clock in the morning popularlyknown as "The Dawn Patrol" whichdrew from sixty to seventy students.These students chose at that early hourof the day this instructor. There aremany illustrious and loyal pupils ofArno Luckhardt from that early morn­ing class such as: Carl and Lester Drag­stedt, Walter Palmer, Conway Ivy, thelate Everett Evans, Ed Compere, Wil­liam, Charles, and Brown Scott, CarlJohnson, Walter Booker, AlexanderRush, Leslie W. Freeman, Howard G.Swann, James R. Regan, Louis Moses,Victor Johnson, J. Paynter Holt, et aLDr. Luckhardt was always a great oneto encourage any young student withtalent. He seemed to feel that scienceis a young man's profession, and hewould do everything he could to helpyoung people of promise. He would meetthem on the threshold and help themcross over-with financial aid, advice,inspiration. He always seemed to senseexactly what was needed and he wouldfill that need. And in turn, these begin­ning scientists, many in number, neverforgot. He became for them a centerthat held. Those who came to this centercarried away new insight and techniques.Throughout his life he kept close con­tacts with many of these exceptionalstudents. In the lives of these that hehelped so much his influence will neverdecline but will continue to spread likethe ripplets and rings on water.One of the great vitalities of his times,Dr. Luckhardt was at his best as a coun­sellor and as a restless prober for knowl-MEDICAL ALUMNI BULLETIN 7edge. No subject in physiology could bebrought up about which he did not knowall the facts explicitly and all the latestfindings. He had a mind possessed notonly by an irrepressible curiosity, an in­exhaustible thirst for facts, a fertile andoften bold imagination, but also a metic­ulous memory.In 1947 he wrote an article for TheEncyclopaedia Britannica on "The Endo­crine Glands." When I stopped in at hisoffice one day he asked me to read thenine pages of script he had written outin long-hand. In covering the early his­tory of the endocrine function he had torecord many investigators and investiga­tions with dates as well as the results ofthe findings. "You know, Lil," he toldme, "I wrote that all straight throughwithout referring to any notes." Ithought to myself, how could it possiblyhave been done?I have that original manuscript in myfiles today, rescued from his waste bas­ket. I also have many reprints and notesfrom Arno-all dated. He always madedated notations. Many times when he gota message from me he would complain:"I got your note, but it wasn't dated. Anote's no note unless it's dated." He hadan old Gladstone suitcase, given to himby his students, on the partition of whichhe had jotted down the dates of everytrip he had taken with it from 1924when he went to Germany as a Rocke­feller Fellow to his last journey to Mi­ami Beach where he died last November6, two days after being awarded an Hon­orary Membership in the American Den­tal Association.His preoccupation with exact littledata like dates on memos explains hispenchant for precision. In a world thatis never too orderly, he loved the won­derful form of beauty which is found inorder.What counts most in the life of anyman is what he has done and the influ­ence he has had on those around him andupon his era. A true Renaissance man,Dr. Luckhardt's work, character, andwritings substantially benefitted physiol­ogy, medicine, surgery, dentistry, andcivilized mankind in general. It is notbeyond reason to guess that ethylene hassaved more human lives than were oblit­erated by the A-bombs. He was activelyassociated with many scientific societiesand, as could be expected from so expertand prodigious a worker, won many cita­tions, medals, honors, and awards. Inaddition to his classic work in anesthesi­ology he carried out important research­es in the physiology of the spleen; of the DEATHS'90. Deyo Leslie Ramsdell, Kansas City,Mo., September 22, age 90.'91. James F. Morning, Denver, Colo.,November 9, age 89.Joseph Eugene Reichert, West Bend,Wis., November 25, age 95.'95. Thomas Zopher Ball, Crawfords­ville, Ind., June 19, age 89.Iegar R. De Vries, Holland, Mich., No­vember 21, age 88.Joseph Ralph Wagner, Palacios, Texas,May 28, age 87.'96. Martin Strand, Chicago Heights, Ill.,November 30, age 83.Frank Rienzi Warren, South Pasadena,Calif., May 28, age 82.'97. Enoch Palmer Webb, Beaver Dam,Wis., June 4, age 86.William Batchelor Whitaker, Chicago,July 23, age 82.'99. Edwin Henry Ehlert, Mayville, Wis.,September 11, age 80.Arthur Lee Hagler, Wauwatosa, Wis.,June 1, age 87.'00. Philip Alfred Krome, Chicago, No­vember 25, age 84.George W. Meisenbach, Plymouth, Neb.,October 2, age 8l.LeRoy Daniel Rockefeller, Long Beach,Calif., November 21, age 84.'01. Roy William Pence, Harlingen, Tex.,October 18, age 79.Francis Fisher Tucker, Daytona Beach,Fla., December 1, age 87.'02. Charles Cyrus Barrett, Princeton,Ill., May 27, age 83.William Lowrie Porterfield, McClure,Ill., July 20, age 77.'03. Wilson Grant Bear, Monroe, Wis.,September 18, age 84.Clark B. Devine, Northridge, Calif., Sep­tember 3, age 78.parathyroid glands, including the natureof parathyroid tetany; of gastric andpancreatic secretion; of hearing, etc.With the help of his fine medical libraryand his ability to read easily MedievalLatin, he wrote many definitive contri­butions to the history of medicine, phys­iology, and dentistry that are of perma­nent value.Admirable as his gifts and achieve­ments were, it was nevertheless most ofall his personal qualities that will be bestremembered by all who knew him-theendearing charm of his wistful expres­sion; his gentle, subdued manner andkind nature; his consideration for othersand his generous spirit. So as we brieflyre-survey his dedicated life and usefulworks we think of him with affection andcherish his example as a man, as a leaderof our profession, and as one of thetimeless scientists. '04. Clyde Berfield, Toulon, Ill., October18, age 78.Dwight Munro Green, Vista, Calif., Au­gust 8, age 78.John Hunt Shephard, .San Jose, Calif.,September 4, age 78.'06. Paul Dean McCarty, Tower, Minn.,April 24, age 73.'09. James F. Cox, Chicago, January 9,age 75.Arthur Stanley Granger, Los Angeles,Calif., August 14, age 76.Edward Allen Oliver, Chicago, Novem­ber 5, age 74.Orie Chris Yoder, Peru, Ill., November 8,age 77.'10. Frank Henry Harms, Augusta, Ga.,September 15, age 82.Fred Blue Olentine, Vero Beach, Fla.,November 5, age 73.Frank Everett Stanton, Sr., Long Beach,Calif., July 29, age 73.'12. Harry McPherson Brandel, Los An­geles, November 16, age 68.William Henry Olds, Los Angeles, Calif.,July 31, age 70.'13. Oliver Otto Nelson, Madison, Wis.,September 28, age 73.Fred J. Wampler, Bridgewater, Va., April6, age 74.'14. Eldridge Stevens Adams, Los Ange­les, Calif., October 18, age 65.William Sullivan Horn, Fort Worth,Texas, December 6, age 69.'15. Carl Randolph Mitchell, Pacific Pal­isades, Calif., August 9, age 65.'16. Herbert Otto Lussky, Evanston, Ill.,September 26, age 70.'16. John Vruwink, San Marino, Calif.,November 18, age 67.'17. Leslie MacKenzie Maitland, Drake,Colo., October 8, age 73.Arthur Lesley Stotter, Cleveland, Ohio,September 11, age 65.'19. Lloyd Lewis Merriman, Duluth,Minn., November 23, age 67.'21. John Harold Fitzgibbon, Portland,Ore., September 5, age 63.Louis Phaon Gambee, Portland, Ore.,September 8, age 65.'22. Lewis Allison Curry, Topeka, Kan.,August 11, age 63.'24. Dale Donatus Corrington, Tallassee,Ala., July 21, age 59.'25. William Frederick Kroener, Sr.,Pebble Beach, Calif., July 16, age 66.'28. Louis C. Morris, Chicago, February23, age 57.'30. Kinsey Ourant English, Chicago,August 6, age 62.James Alexander Laird, Chicago, Octo­ber 31, age 70.'34. Ewing Lee Turner, Los Angeles,Calif., July 24, age 5l.'35. Muriel Fuller, Chicago, August 1, age66.Albert Prescott Mathews, Albany, N.Y.,September 21, age 85.'37. Joseph Raimond, New Boston, Ill.,November 19, age 47.Memorial services for Dr. Luck­hardt were held on March 15. Wil­liam W. Scott, '39, was the principalspeaker.8 MEDICAL ALUMNI BULLETINDR. CANNON RETIRESBy ELEANOR M. HUMPHREYSProfessor of PathologyPaul Roberts Cannon, Ph.D. in bac­teriology in 1921, M.D. from Rush in1926, Professor of Pathology since 1932and Chairman of the department since1940, retired on September 30, 1957.He was born in 1892 in a manse atLexington, McLean County, Illinois, andhas spent two-thirds of his life in Chi­cago, studying, teaching, and experiment­ing at the University.In 1915 he came to the Departmentof Bacteriology to begin his career underDr. Edwin O. Jordan. By the end of1917 he was well on his way to hisPh.D., and, even better, he had met andmarried Joyce Tobin. His degree re­ceded into the future and Joyce had tobe left behind when he entered the U.S.Army. In 1918 he went to Europe andserved as a First Lieutenant in the Sani­tary Corps.Home again at the war's end he foundan instructor's stipend could not bestretched farther than can its muchlarger counterpart (in smaller dollars)today. He and Joyce had to make deci­sions. When his research for his degreewas completed they went South to livefor three years. Joyce saved money whilePaul taught bacteriology at the Univer­sity of Mississippi. CANNONBack in Chicago Paul Cannon movedfrom the North to the South side ofRicketts Laboratory to combine teachingpathology with work for his M.D. atRush which was followed by an intern­ship and a short term as a locum tenens.In 1925 he joined a department wherehis two predecessors as chairman sharedhis major interest and field of endeavor.Ludwig Hektoen was one of the world'sgreat immunologists; H. Gideon Wellswas an equally great immunochemist,and both were available to listen, tocriticize, and to discuss mutual problems.Teaching was a natural vocation forthe son of a minister, and Paul Cannonexcelled. His experience in morgues, in­cluding a term with Erdheim in Vienna,made him a morphologist who saw intissues new problems to solve. In hisresearch he used the techniques and toolsof immunology with added scope, in­sight, and direction because of his ex­perience in pathology. When he becamethe third chairman of his department in1940 it was especially his elective coursein immunology which sparked the fuses,and many of his now distinguished stu­dents were already on their way.It was fitting that his first major hon­or from a national scientific society should be the Presidency of the Ameri­can Association of Immunologists. Hispresidential address in 1941 was trulymasterful in its great insight and fore­sight, and is only today receiving its fullvalidation by techniques not dreamed ofin 1941.It might be said that the recalcitrantrabbit made Paul Cannon an expert onnutrition. Because of the rabbit's short­comings in consuming low-protein dietspreliminary to immunological experi­ments, cages filled with Sprague-Dawleyrats began to replace rabbit cages. Theprotein-depleted rat, multiplied by thou­sands, could in ten to fourteen days testthe biological adequacy of any proteinadded to a standard protein-free diet. Itcould detect biological inadequacy notdiscoverable by chemical means. By thetechnique of specific supplementation,the deficiency could be pinpointed. WithWorld War II under way, the Quarter­master's Department of the U.S. Army,the Office of Naval Research, and manyother agencies and individuals were pre­senting specific questions, needing quickanswers. Rat projects rolled off the as­sembly line and among the rewards werehundreds of problems filed for less stren­uous days to come.At the same time, Paul Cannon's de­partmental duties increased. The teach­ing load became heavier under the accel­erated program; collaborative and con­sultative work, inside and outside theUniversity, increased. Service as consult­ant to the Secretary of War, War-timePresidency of the American Associationof Pathologists and Bacteriologists, edi­torial duties on several important jour­nals and reviews, were all parts of thosestrenuous days. It is easy to see why, inApril of 1946, Paul Cannon was honoredby election to membership in the Na­tional Academy of Science.With the war's end and deceleration,the white rat became a tool for basicresearch. In the last ten years Paul Can­non has investigated many aspects ofprotein synthesis, among them the rolesof the individual amino acids, the modi­fying influences of steroid hormones, in­terrelations of sodium, potassium andtissue proteins. Teaching and helping tolaunch young investigators were, as al­ways, closest to his heart. In the outsideworld, they may be summed up in thealphabet-soup jargon of today: he hasserved the N.R.C., A.E.C., U.S.P.H.S.,N.A.Sc., O. of N.R, Q.D. of A.U.S.,A.M.A., etc., etc., as consultant, chair­man, member of committees, boards,panels, councils. And of course editor-MEDICAL ALUMNI BULLETIN 9�. �. <Buzman )Barron1898-1957By A. T. KENYON, '26Department of MedicineE. S. Guzman Barron, Professor ofBiochemistry in the Department of Med­icine, died on June 26, 1957, at the ageof fifty-eight. Achito, to those who knewhim well, was born on a hacienda in theAndes near the village of Huari, Peru,on September 18, 1898. He was the sonof Sebastian Guzman and Agripena Bar­ron and bore both surnames accordingto Spanish custom. He was one of sevenbrothers. His father educated him athome until Achito was eleven. After atime in preparatory schools, Achito en­tered the University of San Marcos inLima at fifteen. He received his M.D.in 1924. As the foremost in his class hewas honored by the prize for studyabroad and spent the next two years inStrasbourg and Paris.Achito came to America in 1926 towork at Johns Hopkins under LeonorMichaelis, the master of the measure­ment of oxidation-reduction reactions.From this time on his life and work tooka new course, the true course for himand accordingly the final one. Previouslyhe had been concerned with gastric se­cretion, the subject of his first paper in1922 and he was still to deal with themeasurement of bile acids and pigmentsin the blood. His major endeavor lay now,however, with the analysis of the oxi­dation-reduction systems of the cell andwith the role of enzymes in these sys­tems. Studies with Harrop in 1928 onthe catalytic powers of methylene blueon oxygen consumption and with Mi­chaelis in 1929 on the reducing powersof cysteine served as brilliant entrees tothis new field. He was to dwell long and BARRONfruitfully on the place of sulphydrylgroups in the economy of the cell. Hecame to work at Woods. Hole in thesummer where he used marine forms forhis studies and where he was to continueto develop the comparative approach tohis scientific problems.Achito came to Chicago in 1930. Herewith the support of the Lasker Foun­dation he established within the De­partment of Medicine a laboratory asthoroughly dedicated to the fundamentalnature of living things as any anywhere.He provided his skills and his wisdomas a collaborator with many colleagues.The list is very long. We may note workwith C. Phillip Miller on bacterial me­tabolism (1932), with Baird Hastings onlactic acid (1933-34), with Charles Hug­gins on the metabolism of the prostate(1944-46), with Leon Jacobson andships are always thrust on men who, likePaul Cannon, can write clearly, makedecipherable charts, and criticize con­structively. He will keep his editorshipof the A.M.A. Archives of Pathologyand he still has a small office in the de­partment with his secretary, Miss Alex­ander, to help him. Friends of the Can­nons are happy that they will keep aone-room home in Chicago.The permanent home of the Cannonsis in the lovely Fox River country, theSource of their recuperative power eversince their trailer, minus wheels, was setdown in Art Wayne's thicket, purchasedduring the depression. Forethought and hard work have built a beautiful andfunctional home. A second home in thethicket, designed by Joyce, shelters theirson and daughter-in-law and their grand­children. The trailer, expanded, is Paul'sstudy with three views, plenty of deskspace, no telephone, and interruptionsonly when grandchildren call or the din­ner bell rings. Professor Cannon hasmany papers left to write. Farmer Can­non has many tasks to perform withtractor, hoe, saw, and hammer. PaulCannon cannot stay in "retirement"when his experience and wisdom arecalled for, but he will always return withjoy to that bit of wasteland-the thicket. others on the effects of nitrogen mus­tards in neoplastic disease (1946-47).There were studies on ionizing radia­tions, on the properties of uranium, andmasterly reviews on biological oxidationsin 1939, on thiol groups in 1951, on thebiochemistry of cancer with AustinBrues in 1951 among others. In honorof Michaelis he edited Modern Trendsin Biochemistry in 1952, including pa­pers by many of his distinguished WoodsHole colleagues. His friend, Henry BurrSteinbach, our new chairman of zoology,was a contributor.There were many students. DeanCoggeshall tells how in the early daysAchito spent his time with him and otheryoung clinicians introducing them to theelements of biochemistry, always pa­tient, always working with them. Manyof our medical students studied withhim. His graduate students were frommany places. Some came from Peru andelsewhere in South America. Alberto Bar­ron, one of his brothers and now Profes­sor of Biochemistry at San Marcos inLima, was one of them.Achito was greatly concerned with ed­ucation and with medical education inits broadest sense. He was himself amasterful and systematic expositor ofhis subject as those who heard him inlectures and seminars here know. Hedeveloped a distinguished course for stu­dents at the Marine Biological Instituteand became a trustee of this institute.In later years he became indeed a found­er of a new medical school in Arequipa,Peru, where he promulgated the full­time system and sought to establish ascientific school with less pressure forthe training of large numbers of physi­cians than at San Marcos.There were many honors. He heldhonorary professorships from universi­ties in South America known to most ofus only by the magic of their names: SanMarcos, Trujillo and Arequipa in Peru;Uruguay and Brazil. For service to thestate he was awarded Peru's highest hon­or, the Order of the Sun, bearing thesymbol of the sun of the Incas.He had close and enduring friend­ships with many men, but he was neverof the crowd; he could always standalone. He sympathized always with thestruggles of people everywhere for abetter life and extended his hand espe­cially to his countrymen in Peru. Byinstinct and by training he was a citizenof the world, in a spiritual as well as ina temporal sense. With his wife, Cora,and son, Richard, he gave domestic graceto our lives.10 MEDICAL ALUMNI BULLETINRUSH ALUMNI NEWS'04. Archibald 1. Hoyne was presentedwith a certificate for forty years' member­ship and elected a fellow of the AmericanPublic Health Association at their eighty­fifth annual meeting in Cleveland last No­vember.Joseph R. Morrell retired from activepractice and is now in charge of the medicalbranch of the Utah General Depot in Ogden.'13. Ralph H. Kuhns is arranging for the45th reunion of his class this year.'18. Carl T. Olson, St. Petersburg, is oneof three diplomates of the American Boardof Occupational Medicine in the whole stateof Florida.'23. Dorothy Grey of Belfast, N.Y., tellsus that rural and small community practicecontinues to grow heavier with no youngdoctors coming to replace the older ones.Willis Potts discussed "Surgical Emer­gencies in the New Born" at the Irving ParkSuburban Branch of the Chicago MedicalSociety last January.'25. Ralph W. Gerard, professor of neu­rophysiology in the Mental Health ResearchInstitute, University of Michigan, gave the33rd Herman M. Briggs Lecture, "Anxietyand Tension," at the New York Academy ofMedicine last February.Alice Phillips, former associate on theLying-in Hospital staff and recently chair­man of the Department of Obstetrics andGynecology at New England Hospital, Bos­ton, has been appointed director of medicalservice at Mary Thompson Hospital in Chi­cago.Libby Pulsifer, Rochester, New York,wishes the class of 1925 could get togetherfor a day. Why not plan for 1960-the 35thanniversary?'26. Harry A. Gussin visited his son, Zave(J.D. '56) who is now First Lt. in the JudgeAdvocate's office, Washington, D.C. Dr. Gus­sin welcomed the arrival of his grandson,born October 28,1957.'27. Alexander Brunschwig, professor ofsurgery at Cornell, recently returned fromDurban, Natal, South Africa, where he pre­sented lectures and operative demonstrationsduring the Congress of the Medical Associ­ation of South Africa.Isaac M. Felsher was elected to the vicepresidency of the Chicago DermatologicalSociety last January.Hilger Perry Jenkins is president of theCentral Surgical Society.'28. Louis F. Plzak is in practice of gen­eral surgery and associate professor of clini­cal surgery at the Stritch School of Medi­cine. The rest of the family is at the Uni­versity of Chicago. His son, Louis, J r., is asenior medical student, daughter Janice is asophomore medical student, daughter Lindastudies the sciences, son George is a premedi­cal student, and wife Janice is studying for amaster's degree in pharmacology and at thesame time is engaged in research at the Avi­ation Air Force Department.John P. Wood retired from the Navy lastJune after thirty years of service and is nowpracticing radiology in Quincy, Illinois.'31. Henry Harkins, professor of surgeryat the University of Washington, was a guest LETTER FROMKANSASEdward F. Steichen, '31, Lenora,Kansas, writes us:"I have spent all my twenty-six­and-a-half years since graduation inthis community promoting the 'Fam­ily Doctor' legend, of giving medicaland surgical care to anyone in need,as distinguished from routine me­chanical medicine. I have enjoyed giv­ing preceptor training to seniors ofthe University of Kansas MedicalSchool Plan."Our eldest son is a priest, nowstudying Canon Law at the AmericanCollege in Rome. We will visit himnext summer. Our daughter is a nun,now teaching music at Mt. St. Scho­lastica Convent at Atchison, Kansas.Our youngest son is finishing highschool. He is inclining toward medi­cine and states he wants to be withpeople so he can help them. This is hisdefinition of a 'Family Doctor.'"My wife and I enjoy our tripswith the Flying Physicians and theFlying Farmers."I hope some medical studentsreading this will see what a rich re­ward can be had being a 'FamilyDoctor' away from the medical con­centration clinics."speaker at the annual meeting of the South­ern California Chapter of the American Col­lege of Surgeons held in Palm Springs lastJanuary.Harold C. Wagner is president-elect ofthe Chicago Allergy Society.'32. Ying Tak Chan is a staff member ofthe V.A. Hospital, Rehabilitation Division,Excelsior Springs, Missouri. Her work iswith physical medicine and rehabilitation.'33. Charles 1. Dunham, director of thedivision of biology and medicine of theAtomic Energy Commission, received theDistinguished Service Award of that com­mission at its second annual awards cere­mony in Washington last December.'34. Margaret E. Tucker is home on fur­lough from Ludhiana Christian Medical Col­lege in Punjab, North India, where, since1952, she has been professor of radiology.She will return in June.She is visiting her mother, Dr. EmmaBoose Tucker, and her brother, William B.,'33 (South Side) who is director of theTuberculosis Service of the Veterans Ad­ministration in Washington. She has twoother brothers, both physicians-Francis C.practices pathology in Cedar Rapids, Iowa,and Arthur S., of Cleveland, is a radiologist.The father of this distinguished family,Francis F., '01, died November 30 at theage of eighty-seven.The elder Tuckers served for nearly fortyvears as medical missionaries in China. Afterreturning to the United States in 1942 to "retire" they continued to work at PineMountain Settlement School and Hospitalin Harlan County, Kentucky, until 1951. Inrecent years they have lived in DaytonaBeach, Florida. Dr. Emma will make herhome in Chevy Chase, Maryland, with herson, Bill.'37. William S. Klein is a chief of theTuberculosis Service, St. Louis Area Medi­cal Office of the Veterans Administration.Thomas W. Reul, Watertown, South Da­kota, is in general practice and interested ininternal medicine.'39. Emma G. Burt is attending the Uni­versity of Michigan School of Public Healthat Ann Arbor, Michigan.Bearl 1. Ginsburg has been practicingobstetrics and gynecology in Los Angeles forthe last eleven years. The Ginshurgs havethree children.'40. Harold F. Schuknecht, Detroit, gavethe annual Samuel B. Westlake Lecture atthe Jewish Hospital Medical Center in St.Louis in December.'41. Talbot S. Blake is now at the NavyHospital in San Diego, in the department ofurology. He hopes to move his family toLa Jolla soon.MEDICAL ALUMNIHISTORY NOTESam Banks, '34, has supplied an ad­dendum to our "Short History" printedin the Directory:"The Alumni Association held its firstmeeting in June 1934, as the final meet­ing of the class of 1934. This was the firstsizeable class in the medical school andwe were the first to be organized andhold regular meetings."William Beswick was president a,ndI was secretary-treasurer. It was throughour efforts that we formulated plans forthe first Alumni Association meetingheld at International House."Our class selected Normand Hoerr,'31, to be the first president of theAlumni Association. I was responsiblefor having the key originally designed bythe father of Hilger Perry Jenkins, fol­lowing which it was given to membersof the resident staff and after it hadbeen altered (with the approval of theadministration) it was adopted as theOfficial Key of the Association."Dallas B. Phemister was presentedwith a key at this first meeting so thatthe precedent was set at that time andis now a yearly feature of the AlumniAssociation-namely, the presentation ofkeys to outstanding alumni. Therefore,the key was adopted in 1934, not 1944."MEDICAL ALUMNI BULLETIN 11ERRATA FORDIRECTORYFACULTY NEWSA few errors in the Directory, somedistressingly obvious, have come to ourattention. The corrections are listed be­low as the entries would be made in theDirectory so that you may clip and pastethem on one of the blank pages of yourcopy.Enter:*CALLIS, HENRY ARTHUR, '21 (Rush), M­AB'40 Assoc. Prof. Emer., Howard V.,1943 Vermont Ave., N.W., (1) (2306 ESt. N.E., 2), Washington, D.C., AM,Gift. (listed as Harvard University inerror)CARMICHAEL, HUGH THOMPSON, Faculty,'35-'43, P&N-AB'35, Cl. ProL, U. ofIll. 30 N. Michigan Ave. (2); 912 S.Wood St. (12) (5717 Blackstone Ave.,37), Chicago.*CLAY, ERNEST H., '25 (Rush), GP, 1217W. Whittier Blvd., Montebello, Califor­nia; (345 E. Grande Vista St., Whittier),AM.JENKINS, DAVID M., '34 (Rush), 203 N.Main St., Bloomington, Illinois. (listederroneously in Chapel Hill, N.C.)KRONFELD, PETER CLEMENS, Faculty, '28-'33, Oph-AB '31 Prof., U. of Ill., 109 N.Wabash Ave., Chicago 2 (914 Cherokee,Wilmette) .*MILLER, NEWTON, '24 (Rush), 231 N.Main St., Porterville, Calif., AM, Gift.*SCHOOLNIC, JACOB WOLFE, '31 (Rush),M( Al )-AB '52, 130 West Fifth St., AM(604 McKinnon Ave.), East Liverpool,Ohio.*SHACHTMAN, JOSEPH M., '36 (Rush),M(Cv)-AB '46, 6423 Wilshire Blvd.,Los Angeles 48, Calif. (Erroneous spell­ing)Delete:PEERS, ROBERT, Oakland, California. (Er­roneous duplicate listing for R. P. Buck­ley, Duluth, Minnesota).William E. Adams has been appointedto the Advisory Committee on Tuberculosisfor the Illinois Department of Public Wel­fare.. Three of the four guest speakers at theMid-winter Clinics of the Colorado StateMedical Society held in Denver in Febru­ary were William E. Adams and HowellWright of The Clinics and Byron Francis,'29-'38, of Seattle.Wright Adams is general chairman of animportant international symposium on thepulmonary circulation presented by the Chi­cago Heart Association March 20-22. On thecommittee are Emmet Bay, Rush '23, Ben­jamin Gasul, Rush '24, Ormand Julian, '37,Peter V. Moulder, '45, and George Waker­lin, Rush '29.Alf Alving and C. Phillip Miller, Rush'19, were elected Fellows of the New YorkAcademy of Sciences. This honor is con­ferred upon a limited number of memberswho have done "outstanding work towardthe advancement of science."J. Garrott Allen is the editor of Extra­corporeal Circulation, the proceedings of theconference held last September by the UnitedStates Public Health Service in Chicago.Peter V. Moulder, '45, and Lillian Eichel­berger presented one of the major papersfrom their laboratory. John Perkins andWilliam E. Adams participated in the con­ference discussions.John Arnold, '46, spoke on "The Natureof Lupus Erythematosus" at the Januarymeeting of the Chicago Rheumatism Society.A pilot study conducted by William G.Beadenkopf and associates is the basis fora project to study the relationship betweenhardening of the arteries in the human heartand man's activity and other environmentalfactors. This is a cooperative venture of theNew York State Health Department andAlbany Medical College.Ross S. Benham spent the month of Feb­ruary as a Fellow of the China MedicalBoard at the School of Tropical Medicineat the University of Puerto Rico.William Bloom and E. M. K. Geilingparticipated in the program of the Milwau­kee Academy of Medicine on December 7,and Austin Brues was moderator of a ques­tion-and-answer period at the same meeting.M. Edward Davis, Rush '22, is president­elect of the American Association of Ma­ternal and Infant Health. He is also editorof the Association's Bulletin of MaternalWelfare.Robert J. Hasterlik, Rush '38, spent theautumn quarter in the Biophysics Divisionof the Royal Cancer Hospital in Londonworking on a study of long-term effects ofradiation on bone.Paul C. Hodges participated in a paneldiscussion on bone tumors at a joint pro­gram of the Atlanta Society of Pathologists,the Georgia Association of Pathologists, andthe Southeastern Region of the College ofAmerican Pathologists in Atlanta in March.Charles Huggins has been appointed amember of the newly formed scientific ad­visory committee to Roswell Park MemorialInstitute, a cancer research center and hos­pital maintained by the New York State Department of Health in Buffalo. Russell H.Morgan, '40-'52, of Johns Hopkins, is alsoa member of this committee.Nathaniel Kleitman was made an honor­ary member of the International Society forthe Study of Biological Rhythms at its bi­ennial meeting at Semmering, Austria, lastsummer.The University Press has announced thepublication of Stephen Polyak's book, TheVertebrate Visual System, left unfinished athis death in 1955. Heinrich Kliiver, his de­voted friend and colleague, assumed the taskof completing the 1390-page volume withits ten thousand references and over fivehundred illustrations. In recognition of hisaccomplishment, the Committee on Publi­cations in Biology and Medicine of the Presshonored Dr. Kluver at a dinner on Febru­ary 14 at the Quadrangle Club.Peter C. Kronfeld, '28-'33, was guestspeaker at the annual clinical conference ofthe Chicago Ophthalmological Society inChicago in February.Geraldine Light spoke at the PrimeraJ ornada N acional de Anestesiologia held inGuadalajara, Mexico, in November.John R. Lindsay spoke on "The Manage­ment of the Dizzy Patient: The Contribu­tion of the Otologist" in December beforea joint meeting of the Chicago NeurologicalSociety and the Chicago Laryngological andOtological Society.John W. Loop, Resident '53-'54, has re­turned to The Clinics as instructor in radi­ology. He spent last year studying in Europeon a fellowship from the Swedish govern­ment. He brought back a wife, M. Teorell,who is now a sophomore medical student.Clayton Loosli, '37, has been appointeda member of the Committee on AsiaticInfluenza of the Chicago Medical Society.C. Phillip Miller, Rush '19, was appoint­ed a member of the Executive Committeeof the Division of Medical Sciences of theNational Research Council.Russell H. Morgan, '40-'52, of JohnsHopkins, has been appointed radiation con­sultant to Surgeon General Leroy E. Burney.John F. Mullan and Joseph P. Evansdiscussed "Malignant Disease of the SpinalExtradural Space" before the Chicago Neu­rological Society on February 11.Robert G. Page, assistant professor ofmedicine, has been appointed assistant deanof the Division of Biological Sciences incharge of medical curriculum.H. Burr Steinbach was appointed a mem­ber of a special committee to advise theNational Science Foundation on problemsof support of natural history museums.Paul Talalay won the 1957 TheobaldSmith award of the American Associationfor the Advancement of Science for his dis­covery and isolation of enzymes which gov­ern the body's utilization of sex hormones.Dr. Talalay has received a life-time grantfrom the American Cancer Society to pursuehis studies.David Talmage spent the winter quarterworking in the biochemical laboratories atthe California Institute of Technology withDan Campbell, Ph.D., '35. REUNION INSAN FRANCISCOAl Rider, '44, is arranging a get­together in San Francisco in June whenthe American Medical Association meetsout there.The date is Thursday, June 26, at theSheraton Palace Hotel-cocktails anddinner. Send your check for $6.00 to:Dr. J. Alfred Rider,c/o Western Regional Alumni Office,717 Market Street, Room 322,San Francisco 3, CaliforniaRemember the fine meeting Al M.C.'dfour years ago? As usual, wives arecordially invited.12 MEDICAL ALUMNI BULLETINGRADUATE NEWS'32. Arthur J. Vorwald, Wayne Univer­sity, will direct a summer institute in radi­ation biology for high-school teachers of sci­ence under a grant from the National ScienceFoundation.'36. Bernard G. Sarnat, now in practicein Beverly Hills, California, received theSenior Award for 1957 from the Foundationof the American Society of Plastic and Re­constructive Surgery.'38. Clinton L. Compere is president ofthe Chicago Orthopaedic Society.'42. Ed Woodward was appointed pro­fessor and head of the department of surgeryat the University of Florida College of Medi­cine in Gainesville on September 1, 1957.'43. Robert M. McCormack was pro­moted to professor of plastic surgery at theUniversity of Rochester Medical School lastJuly.Fenton Schaffner has left Chicago to be­come research associate in gastroenterologyat Mt. Sinai Hospital, New York.Robert G. Weiner and his wife Betsy,'44, are enjoying Halstead, Kansas, a villageof thirteen hundred people about thirty milesfrom Wichita. Robert is associated with theHartzler Clinic and Halstead Hospital in in­ternal medicine.'44. George L. Nardi, of Boston, partici­pated in the Third International Symposiumon Radioactive Isotopes in Austria in J anu­ary and on his return stopped in Manches­ter, England, to deliver a lecture at theRoyal Infirmary on "Recent Developmentsin Pancreatic Obstruction." In early Febru­ary he presented "Pathophysiology of HiatusHernia, Complications and Treatment" onthe postgraduate program on the patho­physiology of the alimentary canal at theUniversity of California. Later in the monthhe was host for the annual meeting of theMid Century Surgeons Club and presenteda paper on pancreatitis and spoke to the So­ciety of University Surgeons on "Some Ob­servations on Hepatic Flow in Man."'45. Ralph F. Carlson is practicing tho­racic and cardiovascular surgery and endos­copy in Evansville, Indiana.Harry W. Fischer, Iowa City, is associateprofessor of radiology at the State Univer­sity of Iowa School of Medicine. He wantsto encourage ten- to twenty-year reunions;says they work well at Iowa.Edward N. Horner, San Marino, Cali­fornia, has been appointed assistant clinicalprofessor of obstetrics and gynecology at theCollege of Medical Evangelists.The Warren Wilmers, Burlingame, Cali­fornia, announce the arrival of a daughter,Heidi Lynne, on October 18.'47. J. R. Barberio left the surgical staffof Fresno V.A. Hospital and entered practiceat Oceanside, California, last September.Robert G. Frazier is leaving the StateUniversity of Iowa to become assistant tothe Executive Secretary of the AmericanAssociation of Pediatrics on March 15. Hewill live in Evanston, Illinois.Eugene A. Weber, West Covina, Califor­nia, has been in private practice of internalmedicine since 1955. He was married in 1950and now has four children, ages six to one,who keep things lively. Nearby are Ed Hor­ner, '46, and Newell Johnson, '50. '48. Charles Buhrow became a diplomatein radiology last September. He is deputychief and senior surgeon at the U.S. PublicHealth Service Hospital, Baltimore.Walter Lawrence, Jr., is practicing gen­eral and neoplastic surgery in New YorkCity. He has staff appointments at the Me­morial Center for Cancer and the New YorkHospital.Ernst R. Jaffe, Leonia, New Jersey, aftercompleting a two-year research fellowship,has remained on the full-time faculty of theAlbert Einstein College of Medicine with therank of assistant professor.We have just heard that Robert T. S. Jimis a patient in the Leahi Hospital for Tuber­culosis in Honolulu. May his visit be brief.'49. Charles Bacon, Coldwater, Michigan,recently opened a private practice of generalsurgery. He is certified by the AmericanBoard of Surgery.'51. Ralph M. Stephan finished residencyand is now in the private practice of ob­stetrics and gynecology in Tampa, Florida.He has two children, a girl, one, and a boy,four years old.'52. Robert S. Cox is a diplomate in clini­cal pathology with honors and in anatomicpathology in 1957. He is chief of the researchand development service and chief of clini­cal pathology at the Letterman Army Hos­pital in San Francisco.Paul M. Grissom is now assistant chiefin psychiatry at Lackland Air Force Hos­pital in San Antonio. His wife "Julie" (Eliz­abeth) B.A., '48, B.S., '49, died on October 8,1957, following Caesarian delivery of theirson, Marc.Kenneth Hayes, San Jose, California,is in private practice of internal medicine.The Hayeses have three children.Irwin Rich, Chicago, entered practice oforthopedic surgery last July and is on thestaff at Michael Reese Hospital. He has twochildren-son, Joshua, born in December,and daughter, Deborah, two years old.'53. Carl Ebersole, Tucson, Arizona, hasbeen in the practice of anesthesiology sincelast June.Robert Edwalds, Galesburg, Illinois, ischief of the intensive treatment service atthe Research Hospital where Tom Tour­lentes, '47, is superintendent. Since last yearthe Edwalds family has increased to four­two girls and two boys. Bob delivered apaper at the New York division meeting ofthe A.P.A. in November and saw HermanWolfson, '53, who is practicing pediatricsin Newington, Connecticut.Marjorie Montague, Seattle, is now Mrs.Wesley M. Wilson. Her husband is M.S. inBusiness Administration, U. of C., 1954.Eric F. Sharton, Boston, is in the prac­tice of internal medicine and an instructorin medicine at Tufts University. He teachesthird-year students at Boston City Hospital.They have one year-old son.Marvin Weinreb completed residency indermatology at the New York Skin andCancer Institute and opened a private prac­tice in Hayward, California. His wife, Ilene,and two daughters, Rachel and Debbie, likeCalifornia.'54. Jim Keasling is a second year resi­dent in surgery at St. Luke's Hospital in San Francisco. The Keaslings now have' aboy seven months old. Jim sends best wishesto 1954 graduates still at The Clinics.The Albert Levys announce the arrivalof their son, Daniel, on July 11. The wholefamily is in Chicago and Albert has resumeda pediatrics residency at Bob Roberts.Alvin Mesnikoff last year was chief resi­dent in psychiatry at the Columbia-Presby­terian Medical Center, New York, and onJanuary 1 was appointed senior clinical psy­chiatrist on the staff of New York StatePsychiatric Institute and to the faculty ofP. and S. He plans also to open a privatepractice this year.'55. Arnold K. Brenman was married inMay, 1957, to Jeannette Kmetz of Phila­delphia. Arnold is in the Army as chief pedia­trician at Rodriquez Army Hospital in SanJuan, Puerto Rico.Martin Flax is in the Air Force, assignedto the Armed Forces Institute of Pathologyas chief of the biophysics section. JonathanDavid Flax, his second child, was born onJanuary 30.E. Jack Harris is now married and live,on Long Island.David L. Singer, Boston, is a senior resi­dent in medicine at Beth Israel Hospital. InJuly he will have a fellowship with an endo­crine group at the same hospital.Thomas F. Ednie, Presque Isle A.F.B.,Maine, and his family, two boys and thethird one due in March, are enjoying theirstay in the Potato and Ice Country. Tomhad accepted a regular commission in theAir Force and has recently been awarded theaeronautical rating of Flight Surgeon.Richard Woellner married MargaretGraham, a medical social worker fromMinneapolis, on December 28. Richard is inPensacola with the Navy on the staff of theSchool of Aviation Medicine.'56. Eugene Anderson, New Orleans, willreturn to The Clinics in July to completeresidency in medicine.Edgar C. Bristow III is a surgeon at the39th Infantry at Fort Lewis, Washington.Nelson Moffat, '55, is also there.Dorin S. Daniels is taking a one-yeargeneral-practice residency at St. VincentHospital in Portland with the aid of $1,000Mead Johnson Award for graduate training.He plans to settle in Vale, Oregon.Erl Dordal is a resident in surgery at theGundersen Clinic, La Crosse, Wisconsin. Hewill return to The Clinics July first as aresident in internal medicine.Robert Druyan, after "a delightful yearat the Brigham," will spend the next twoyears at the Naval Medical Hospital inBethesda, Maryland, in research.Dean Miller began a general practice inMonroe, Wisconsin, in February.Alan M. Weintraub completed intern­ship at the University of Pennsylvania inJuly, and is now Lt. in the Navy, stationedat Main Naval Dispensary, Washington,D.C.Perry Zevin is a Captain in the Armystationed in Korea. He is a surgeon of the1st Battle Group, 7th Cavalry, 1st Division.'57. Richard Cole, Chicago, was marriedto Fern Feltinton on June 17, 1957.MEDICAL ALUMNI BULLETIN 13Junior JEAN STIEGLITZ in the chern­istry laboratory, a medical counterpart ofher late grandfather, Professor and Chernis­try Chairman Julius Stieglitz.Senior BARBEE and Intern PULERWITZmanage the New Emergency Room at night.Seniors TED SCHULMAN and FRANK·LIN STAR assisting WILLIAM KABISCHin Gross Anatomy.Sophomores in histology laboratory: LE·LAND HAWKINS, ROBERT MURPHY,DUANE TAEBEL, and CLAUDE GIONET·TI.Sophomore RANDY SEED engrossed inmicroscopic studies.14 MEDICAL ALUMNI BULLETINREPORT FROM THE DEAN OF STUDENTSFreshmen LAUREN PACHMAN, ARTHUR AUERBACH, ROBERT PERLMAN, BRIANGALLAGHER (Ph.D. candidate in biopsychology), PHILIP EATON, and HARLAN GEP­HART convinced (with absorptions but perhaps without comprehension) by one of thefamous PERKINS' demonstrations.STUDENT LOANSThe soaring expenses of medical edu­cation in a world of high costs is re­flected nowhere more dramatically thanin the ever-increasing need for financingaid to students.In 1950 funds for this purpose totaled$22,775. Today we have $106,825, andwe could use at least twice that much.On January 1 there was less than $6,000on hand for new loans.The summer quarter, 1958, will bringnew demands. Then, for the first time,our seniors will begin a four-quarter finalyear of study, and medical tuition willbe increased to $1000 a year.Since 1950, of six new loan funds,four have been created through the di­rect efforts of medical alumni. Withoutthem, we should be in a sad state indeed.The first of these funds, established inApril 1950, is the Basil C. H. HarveyLoan Fund. It has grown steadily inthese eight years and is now our secondlargest loan fund-$21,670.00.In December 1950, Carl G. Johnson,Rush '22, of Long Beach, California,established a new loan fund.The Medical Alumni Loan Fund be­gan four years ago with a treasury giftof $2,860 from the Medical Alumni As­sociation. Life membership dues, interest on bonds held by the Association, andindividual gifts from alumni have in­creased the fund to $14,319.The fourth of these alumni-inspiredloan funds was established just this pastNovember in honor of Paul R. Cannon,Rush '25, on the occasion of his retire­ment from the University.With the continued loyal and generoussupport of Medical Alumni, I look for­ward to the day when capable and de­serving medical students can borrow asmuch as they need to finance their med­ical education at our University.]. ]. CEITHAMLFRESHMAN CLASS-19S7On October 2, 1957, the Class of 1961came to our campus for the first timeto begin a three-day orientation programto the formal beginning of medicalstudies. This superb class of six womenand sixty-six men was selected fromeleven hundred applicants and is com­posed of representatives of forty-threeuniversities and colleges.Our own undergraduate College, asexpected, contributed the largest num­ber of students-fourteen. Four studentscame from Stanford and from Oberlin, and three from St. Olaf College - inNorthfield, Minnesota. The complete listof all schools represented is:Augustana (Illinois)Beloit College (2)Brooklyn CollegeUniversity of California(Los Angeles)Carleton College (2)Central State College(Oklahoma)University of Chicago (14)Columbia UniversityCornell UniversityEarlham College (Indiana)Eastern Illinois State CollegeHarvard University (2)Hiram College (Ohio)Illinois CollegeUniversity of Illinois (2)University of IowaJohns Hopkins UniversityLawrence College (Wisconsin)Luther College (Iowa)Middlebury College (Vermont)Mount Holyoke CollegeNebraska Wesleyan UniversityNorth Central College (Illinois) (2)Northwestern University (2)Oberlin College (4)Ohio State UniversityPurdue University (2)St. Joseph's College (Indiana)St. Olaf College (3)Seattle UniversitySouthern Illinois UniversitySouthern Methodist UniversityStanford University (4)Swarthmore CollegeTufts College (2)Walla Walla College (Washington)Washington University (St. Louis)University of WashingtonWellesley CollegeWheaton College (Illinois)University of WisconsinCollege of Wooster (Ohio)Yale UniversityThe average age of the entering fresh­men was twenty-two years and forty-twomembers of the class were either twenty­one or twenty-two when they enteredour medical school. The age spread wasfrom nineteen to twenty-nine.The college scholastic records of thesestudents reflect the excellent intellectualcalibre of these young men and women.Although there were a few in this groupwith C+ grade averages and an appre­ciable number with B-, over two-thirds(52) of the class had college averages ofB+ and higher. This was a pleasant sur­prise to the Admissions Committee be­cause their selection had been made' onpersonal qualifications as well as aca­demic achievement.Of the entering freshmen, fifty-six hadBachelor's degrees; in addition four wereMEDICAL ALUMNI BULLETIN 15Freshmen ROBERT CAPLAN, LAMPIS ANAGNOSTOPOULOS, and ALBERT BROWNLEE learn that there really are holes in the head.Masters of Science and one is a Ph.D.in a basic science.Well over half the students (44) camefrom families in which one or the otherof the parents had graduated from col­lege. One third were of families in whichneither parent attended college, and onethird in which both parents had gradu­ated from college.Of the six women in the class, one ismarried. Of the sixty-six men, thirteenare married and five of them each hasone child. Incidentally, twelve of themen are veterans who have served acombined total of thirty-two years inthe United States Army, Navy, and AirForce.Three of our freshmen are of foreignbirth (Greece, Germany, and Korea),although all three are now American cit­zens and all three received their pre­medical training in this country.They come from a wide diversity offamily backgrounds. For example, thefathers of these students are engaged ina broad spectrum of different occupa­tions in the fields of the professions,business, and labor. There are includedin this group fourteen doctors, five engi­neers, five merchants, four college pro­fessors, four dentists, three lawyers, twofarmers, two mechanics, a banker, a bank examiner, a high-school teacher, ahigh-school principal, a public-school su­perintendent, a minister, an Army officer,a toxicologist, a postal worker, a phar­macist, a machinist, as well as a numberof different kinds of office workers,skilled and semi-skilled laborers, and thelike.Furthermore, although the majorityof the mothers (50) of these freshmenare housewives, ten are elementaryschool teachers and two are practicingdoctors and two more are secretaries.Others of these mothers include a nurse,a dental receptionist, an assistant to atax collector, and a department-storebuyer.From this heterogeneity of family andacademic backgrounds have come theseventy-two fine young men and womenwho constitute the Medical Class of1961. They have now completed theirfirst academic quarter of study and bytheir excellent performance both in andout of the classroom have already justi­fied the many long hours of deliberationspent by the hard-working and con­scientious Committee on Admissions intheir selection.JOSEPH]' CEITHAMLDean of StudentsDivision of Biological Sciences COULTER DIESAs we go to press, we have news ofthe death, March 17, of Merle C. Coul­ter, Associate Dean of the Division,after a prolonged illness.DEATH OFDR. HARVEYOn Saturday, February 15, Basil C.H. Harvey died in Billings Hospital. Hewas eighty-three years old. He is sur­vived by a daughter, Mrs. Thomas G.Kindel of Grand Rapids, Michigan.He was a teacher of anatomy at theUniversity since 1901 and Emeritus Pro­fessor since 1940.As the dean in charge of medical stu­dents' affairs from 1923 to his retire­ment and again for a year during thewar, he is known to more of you thanany other member of the Universityfaculty.Memorial services for Dr. Harvey willbe held in Bond Chapel at 4 :00 P.M.on April 7. The speakers will be DeanL. T. Coggeshall, Rev. Granger E. West­berg, Percival Bailey, and Peter P. H.DeBruyn.16 MEDICAL ALUMNI BULLETINABOUT YOUR DUESAMERICAN MEDICALEDUCATION FOUN­DATIONContributions to medical educationthrough the American Medical Educa­tion Foundation have proved of greatbenefit to our medical school.Earmarked contributions are turnedover to the designated medical schoolsintact. Un designated gifts are pooled anddivided evenly among all eighty-five med­ical schools in the United States.Many physicians prefer to have theircontributions for medical education ap­ply to their own schools. The AmericanMedical Education Foundation is will­ing to accept such assignments, and lastyear the American Medical Associationmatched earmarked as well as unear­marked funds before distribution.The amount of earmarked contribu­tions for The University of Chicago hasrisen from $3553 in 1953 to $15,272 in1957. This is a substantial portion of allgifts from medical alumni.; '.f.. gift to the American Medical Edu­cifhQ,n Foundation may be earmarkedfor'-a' particular school any time duringthe year in which it was made. For in­stance if you have already made a con­tribution and you wish now to have itallocated to The University of Chicago,the American Medical Education Foun­dation will honor your request as longas it reaches their hands before Decem­ber 31,1958, the day before the distribu­tion of funds is made.1958 REUNIONJUNE 12On Thursday, June 12, the evening be­fore Convocation, the Medical Alumniwill gather to do honor to the graduatingclass.The Rush class of 1908 is invited tocelebrate its fiftieth anniversary reunionwith us.John Van Prohaska, '33, is makingplans for a twenty-fifth anniversary cele­bration for all classes up to and includ­ing his own from the South Side, theclass of 1933 from Rush, and the internand resident staff from The Clinicsthrough 1933. He already has over fiftyacceptances.The dinner will be held at the HotelShoreland and Walter L. Palmer, '21,will be the banquet speaker.Ballots and announcements will besent to you early in May. DIRECTORYThe Medical Alumni Directory, re­ceived by most of you in January of thisyear, is impressive in its beauty andaccuracy. Jessie Maclean, our executivesecretary, deserves the entire credit forthis remarkable job.The directory is a symbol of organi­zation and people. Sometimes the activi­ties and expenditures of an organizationsuch as this are difficult to explain be­cause of its multidirectional aims. Thissymbol of adult size, magnificence, andabilities (e.g., to know where 99% ofyou are!) has produced many reactions,most of them flattering and often appre­ciative of some need fulfilled. We mustadmit to a feeling of attainment, of get­ting into orbit.The directory has been mailed to ac­tive members only. Many alumni havebecome active within the last few monthsand directories have been dispatched tothem. We shall continue to supply newmembers as long as we have copiesavailable.P. V.M.BULLETINof the Alumni AssociationThe University of ChicagoSCHOOL OF MEDICINE9 SO East Fifty-ninth Street, Chicago 37, IllinoisWINTER 1958 NO.2VOL. 14EDITORIAL BOARDPETER V. :MOULDER, Chturman""RIGHT ADAl\IS ELEANOR i\I. HUMPHREYSL. T. COGGESHALL HUBERTA LIVINGSTONEROBERT J. HASTERLIK CLAYTON LOOSLIWALTER L. PALMERJESSIE BURNS 1I1ACLEAN, SecretarySubscription with membership:Annual, $4.00 Life, $60.00 We sometimes get inquiries about "du­plication of dues" to the Medical Alumniand to the University Alumni Association,A word of explanation might help to clearup this confusion.The Medical Alumni Association isseparate from the general Alumni Asso­ciation of the University. Although wework closely with the general organiza­tion in sharing information about alumni,we have separate dues-and-gift programsand completely separate budgets.Membership dues in the general Alum­ni Association include a subscription tothe monthly University of Chicago Mag­azine. Life membership dues are held inan invested fund to guarantee the per­petuation of the organization,In the Medical Alumni Association,annual dues are used to support ourwhole program, as a part of our budgetfrom the Division of Biological Sciences.Our quarterly Bulletin is sent to allmedical alumni of the University. Lifemembership dues are deposited to ourMedical Alumni Loan Fund for students.The Alumni Foundation, not theAlumni Association, solicits gifts fromall alumni of the University of Chicago.Most of the Alumni Gift is for unre­stricted funds for the University, but analumnus has the privilege of saying forwhat purpose his gift should be used.The Medical Alumni Association re­ceives gifts from its members for use inthe Division for student loans, or for anypurpose that may be designated.Part of the information shared by thetwo organizations is a record of gifts.As many of you have reason to know,for instance, an alumnus who gives ahundred dollars to the University throughthe Medical Alumni Association for anypurpose, is listed in the Alumni CenturyClub. Likewise we are informed of allgifts made by medical alumni to theAlumni Foundation and we enter thisinformation on your cards here.