Volume 8 WINTER 1952 Number 2!lalles )Surton �hcmistcrJULY 15. 1882-DECEMBER 28, 1951 I WISH to acknowledge the debt andgratitude of our University to a manwho was and is one of its most cherishedfigures, Dallas B. Phemister. Engrossedas he was in his great work of teachingand investigation, and in creating a medi­cal center in which these things could bemade more productive, it never occurredto Dr. Phemister that he was one of theleaders of the University, and it wouldhave amazed this modest man had it beensuggested. He was never heard in publiccontroversy; he engaged in no manipula­tion; he held scrupulously aloof from thedebate that engaged the attention of themoment. His deep and pervasive influenceupon this University came from his exam­ple-from his high dedication to his work,his standards of perfection, his kindly, ju­dicious, and rigorously honest character.So great was the admiration and respectfor this man that many in the communityshaped their judgments by what theysensed must be his. His presence on thesequadrangles was a constant reminder thatthe greatest of human characteristics arethe most powerful in settling the affairsof man.It is not unusual for the faculty of auniversity to seek to promote the com­mon good above their own special interest.But even in such a community, somestand out above others: their competenceis more marked, their dedication is morecomplete, their selflessness is more abso­lute. Dr. Phemister is one of this specialgroup, one of the truly great men of ourUniversity and of our time. He is great asthe truly great should be: there is great­ness in what he did and what he was.Dallas Phemister gives reality to the faithupon which our University rests-thefaith that men by unselfish dedication,effort, and intelligence can build a betterworld for man.-LAWRENCE A. KIMPTONOn December 28 the entire Univer­y community as well as physicians, pa­nts, and friends throughout the countryre saddened by the death of Dallas B.emister.Dr. Phemister had been in excellentLIth until November 28 when he de­oped the classical symptoms of acutecendicitis, recognized them as such,j regretfully cancelled his trip to St.uis to attend the festivities honoring his long-time friend, Dr. Evarts Graham,retiring professor of surgery at Washing­ton University. The operation, performedby Dr. Lester Dragstedt, disclosed theexpected acute infection of the appendixand gave no cause for concern. However,because of an earlier history of thrombo­phlebitis and pulmonary infarction, anti­coagulant therapy was instituted at once.In the ensuing weeks, thrombophlebitis,difficult to control, developed first in the arms and later in the right leg. The courseof the complications was studied by Dr.Phemister with his customary intense in­terest, objectivity, and desire that allmight learn. The gravity of the situationwas fully understood and calmly facedwith a composure and courage that willalways be remembered by his colleagues.The terminal episode of massive pul­monary embolism came swiftly. without[C ontin lied on page 5]2 MEDICAL ALUMNI BULLETINDR. PHEMISTERBy DEAN COGGESHALLWe are a privileged group because weconsider ourselves to be friends of Dr.Dallas Phemister. If the words great andgood can be descriptive of anyone, he wastruly worthy of them. His contributionsand achievements, the esteem and affec­tion in which he is held, make difficult afitting tribute to his character as a physi­cian and a man. The difficulty is in find­ing words at this moment of sadness thatnot only measure his leadership and abun­dant creativity, but also express the ex­tent of the loss of those who knew andworked with him. The task is made easier,however, by the fact that those of us hereassembled understand full well his truecapacities and any inadequate phrasescannot possibly detract from him. Themedical center of the University reflectsso much of his spirit, attitude, and idealsthat his presence will be felt always inevery patient's room, class, laboratory,and corridor; yet, in spite of any rational­ization we may make, there is a shock inthe realization that from this time for­ward we must go on without him.Dr. Phemister was one of the outstand­ing figures of a period which has producedrevolutionary advances in medicine. Hecontrij�uted his full share and more tothis great development, through teaching,research, and a long and distinguishedcareer as a clinical surgeon. But evenmore he contributed to this developmentby his progressive and inquiring attitude,and his devotion to the experimental as­pect of medicine. By his example anddedication he exerted a continuous forceon the direction of medical interest andactivity.His life began with that same simplicityand modesty which were so markedly histraits through life, no matter what hiseminence and authority. Born on a farmnear Carbondale, he attended a countryschool and after graduation from highschool in Carbondale he continued at theNormal School of Northern Indiana, atValparaiso. It was there he decided tobecome a physician, and he was a mem­ber of the first full-time pre-clinical classof Rush Medical College taught on theQuadrangles of the University of Chi­cago. He took his degree from Rush in1904, served an internship at Cook Coun­ty Hospital, and entered private prac­tice. It was at this time, as a member ofthe Rush faculty, that he began to de­vote his life to his principal interest-theteaching and investigation of medicine.In order to provide funds to studyabroad he entered private practice at LaGrange, Illinois. Five years later he leftto attend various teaching clinics on thecontinent, spending somewhat more thana year at the pathology laboratories inVienna where he began to develop one ofhis major interests, the study of bone pathology. One of the many stories illus­trative of his influence on those whoknew him occurred a year after he hadreturned from that laboratory in 1 9I1. Hesent a note to his lifelong friend, Dr.Vernon David, who had followed him tothe same laboratory, asking if he wouldspeak to Theodore the diener and requesta few specimens for his teaching andstudy collection. The impression this seri­ous minded student had made on thediener was so great that he sent imme­diately fifty of the prize specimens fromthat famous collection.As stated, in 1911 he returned to Chi­cago, resuming his appointment at Rush,and, after holding the Senn Fellowship,served for four years as assistant to thegreat surgeon, Arthur Dean Bevin atPresbyterian Hospital. During this period,in 1914, he married Katharine Gannon,and to this happy union came Mary,Dean, and Bruce. In World War I he en­tered the Medical Corps as a captain inthe Presbyterian Hospital Unit, January1918, serving in evacuation hospitals atsuch heavy battles as Chateau-Thierry,St. Mihiel, and Cornpiegne, and he camehome with the rank of major. He returnedto Rush Medical College and his privatepractice with headquarters at Presbyter­ian Hospital.In the post-war period the Universityof Chicago began active organization ofthe new medical school for which it hadreceived an initial grant of a million dol­lars in 1916. Dallas Phemister was a pro­fessor of surgery at Rush and widelyrecognized as a leading surgeon when theUniversity asked him to become chairmanof the Department of Surgery of an insti­tution not yet built. He accepted the offerof the University at a personal sacrificewith characteristic selflessness. He saw init an opportunity to develop the experi­mental side of surgery and to make it asclearly a fundamental science as physiol­ogy or anatomy. He believed he could dothis best on the South Side where therewere superior facilities, an opportunityfor close association with an outstandinggroup of basic scientists, and a programthat would make available all his ener­gies and his staff's for the care of patients,teaching of students, and investigativeactivities.To this new position in the UniversityClinics, Dr. Phemister devoted himselfwith unremitting energy, imagination, andenthusiasm. He planned the organizationof the Department of Surgery, and re­cruited a staff that satisfied his exactingstandards. He sought men whose primarytraining had been in research and investi­gation, confident that he had the insightto recognize those among them who alsocould and would become great surgeons.Dr. Phemister was not satisfied with hisown preparation; in the interval while theClinics were being built he went abroadagain for further postgraduate study. In London he began his work on operatishock which is one of his notable contbutions to medical advance. It was IPhemister's work, together with thatDr. Blaylock and others, which intiduced the universal use of transfusionsshock and the practical eliminationshock as a cause of death.With the completion of the Clinicsthe autumn of 1927, Dr. Phemister begwhat is now pointed to everywhere as Ioutstanding career .of twenty-four yeaof teaching and research at the Univesity. His industry was always tremedo us ; he worked long hours, and his cocern for his patients brought him to thospitals every day of the year. He blieved so firmly in the purpose of the istitution that no effort was too great fits success. In the early days he wasgeneral supervision of all surgical castand made rounds with his full staffevery patient, a practice he surrendenonly when the numbers became too largBy this time, too, he had created an errnent department and it was clearly unneessary for him to give his attentionevery case.He worked constantly to establish arencourage the spirit of research in the dpartment. As with his teaching, he dthis by example and encouragement, COltiriuing his own investigations. Those COltributions that place him in medical hitory are, in addition to his studiesbone pathology and shock, his methods Idiagnosing bone tumors and infection, hprocedure for equalizing the growth Ibones in children and adolescents wheidisease has altered the process, his surgcal technique for the previously inopeable cancer of the esophagus, and his 01servations and descriptions of the deveopment and types of gallstones.In his twenty-four years here, DPhemister was no less a teacher thanscientific investigator. He was as mueconcerned with the young medical studeras he was with residents who worked withim for five-year periods of postgraduattraining. He was a demanding and a stricteacher, but he gave much more than hever asked, sparing no effort or detail. Hreviewed a student's history of a patienwith the same attention and thought thshe gave to a consultation with a colleaguiOf his own work, clinical or investigative, he was even more scrupulously critical, pointing out with unwavering honest:and objectivity his own mistakes. Thiforthrightness set for the generations 0his students and associates an examplthat stimulated them to strive for his kimof exactness. To be satisfied with nothimless than perfection is a mark of ;Phemister-trained surgeon. How successful he was in his teaching may be gauge,in part by the fact that the strong department he built is staffed by his stu[Continued on page ISJMEDICAL ALUMNI BULLETIN 3fHE BEN MAY LABORATORY FOR CANCER RESEARCHThe Ben May Laboratory for CancerR.esearch was established in the Division)f Biological Sciences on July I, 195 I.[he Laboratory is thirty-four men andNomen dedicated to the advancement ofnedicine through research. The aim of.he Laboratory is to provide a new centerfor advanced study, for research, and for.eaching experimental medicine.The specialty of medical research has:ome to demand the association of minds.rained in discovery. Creativity in medi­:ine requires a sense of leisure for thevorkers combined with no lack of theoreparative devices and measuring instru­llents of science. The function of a greatmiversity must be to find or to train menmd women who can discover and to fur­iish them with an unharassed opportunity'or reflection and work in well-equippedaboratories. Our young medical schoollas always specialized in the opportunitiest provides undergraduate students ofnedicine to participate in research; andibviously recruiting brilliant men for:areers in scientific medicine is one ofhe critical operations in the medical.stablishment. These are the frontier ac­ivities in which the Ben May Laboratorys engaged.Mr. Ben May of Mobile is an old friend'f the University who has given importantid in cancer research since 1943. Mr.Jay represents a rare type: a successfulusinessman who is interested both ineading science and supporting medicalesearch, as many another might maintainracing stable. Because of his great sup­ort, both moral and tangible, the Labo­'ltory was named in his honor by Dean.. T. Coggeshall.The Ben May Laboratory is housed in. verity rooms located on the top floort MR. BEN MAYand in the basement of the Nathan Gold­blatt Memorial Hospital for NeoplasticDiseases. All the laboratories consequent­ly are new and were designed by thepresent staff and are perhaps the finestmedical research laboratories in existence.One room is a combined library and con­ference room where coffee is served freeevery day at 4 :00 P.M.; visiting alumniand others are always welcome but arewarned in advance that a motto on thewall says, "Please talk shop."The present interests of the Laboratoryare fundamental and lie in the fields ofbiochemistry, especially intermediarymetabolism; organic chemistry; experi­mental pathology; and clinical physiologyof neoplastic disease.In biochemistry the senior workers areDR.. JEAN srcs, DR. TORU MIYAJI, and DR. PAUL TALALAY, of the Ben May)oratory. A. L. Lehninger, Eugene P. Kennedy, andH. G. Williams-Ashman. The achieve­ments of these young men already areenormous. Dr. Lehninger is internation­ally famous for his work on the inter­mediary pathway in the metabolism offats; for his contributions to the study ofphosphorylation and energy-transfer inthe growth and function of the cell; andfor his studies on those power plants ofthe cell, the mitochondria.In organic chemistry the staff consistsof E. V. Jensen, J. A. Sice, T. Myers, andH. Jacobson. The interests of this groupare in steroid chemistry and the syntheticproduction of competitive inhibitors ofhormones and enzymes. Dr. Jensen is anexpert in free radical reactions and theiruse in organic synthesis. One of his prin­cipal interests is in the design and manu­facture of compounds which eliminatethe physiologic effects of androgen with­out themselves having an estrogenicfunction.In experimental pathology Dr. PaulTalalay has charge of fine air-conditionedlaboratories for the care and breeding ofrats and mice and the maintenance of ex­perimental tumors. At the present timeeight transplantable tumors are main­tained for use of all workers, really atremendous task. Dr. Talalay has wideinterests among which is the field of themetabolism of steroids by bacteria. Dr.Toru Miyaji is engaged in the study of"ascites tumors"; these neoplasms growin the peritoneal cavity of rats and miceas free swimming isolated cells, whereaswhen transplanted in the muscles they de­velop into solid masses of tissue.Another facet of the work is an investi­gation of the relationships of the adrenalcortex to neoplasms. They are very close.The adrenal cortex under special circum­stances is the cause of mammary cancerin mice at least, as was discovered earlierin Bar Harbor. It is known that theadrenal cortex also protects the organismagainst the growth of certain tumors suchas lymphomas, these tumors growingmore rapidly when the adrenal glands areremoved. We have recently found thatother tumors, namely certain cancers ofthe breast and of the prostate in the hu­man are dependent on the integrity of theadrenal cortex. A method was worked outin conjunction with Dr. D. M. Bergenstalof the Department of Medicine wherebybilateral adrenalectomy in man can becarried out regularly with very slight mor­bidity or mortality. Frequently the ef­fects on even widespread cancers are ex­tensive. the lesions undergoing regressionsoon after excision of the adrenals. Thisnew therapy is restricted to appropriatemammary and prostatic cancers but pro­vides a treatment for these patients forwhom nothing previously was available.CHARLES HUGGINS4 MEDICAL ALUMNI BULLETINRUSH ALUMNI NEWS'98. E. V. 1. Brown was awarded theLeslie Dana Medal for the prevention ofblindness at a dinner held in his honor atthe Chase Hotel in St. Louis on Decem­ber 7 by the St. Louis Society for the' Blindin cooperation with the National Society forthe Prevention of Blindness and the Asso­ciation for Research in Ophthalmology.'02. "In recognition of nearly 50 yearsof exceptional service to his patients andto medicine, Dr. A. C. Yoder, of Goshen,Indiana, was awarded the fifth annual gen­eral practitioner's gold medal and named'general practitioner of the year' by theHouse of Delegates of the American Medi­cal Association at the Los Angeles clinicalsession. The winner of this a ward is se­lected each year from a list of three namessubmitted to the House of Delegates bythe Board of Trustees, who in turn re­ceive nominations from each of the stateand territorial medical societies," I,A.M,A.,147:1671, 195I.'04. Kellogg Speed was presented witha citation by Dr, E. J. McCormick, Trus­tee and Chairman of the Advisory Com­mittee on Scientific Exhibit for his con­duct over the years of the AmericanMedical Association's Exhibit on Frac­tures. This citation was presented recentlyduring the Fifth Clinical Session of theAmerican Medical Association in Los An­geles, California.'I3. Clyde Brooks lives in Coral Gables,Florida, and practices medicine in EdenicCity.'I6. C. D. Swickard says he needs twoyoung doctors in Charleston, Illinois, tohelp him carryon with the medical andsurgical requirements of that area. Thirtyyears ago there were fifteen fairly activephysicians and now there are only sixactive and two partly active. Dr, Swickardthinks it would be a wonderful locationfor two men who expect to be generalpractitioners and one who wishes to spe­cialize in eye or E. E. N. T.'22. Charles H. Piper has a very busypractice in eye, ear, nose, and throat onthe west side in Chicago,'23. William J. Baker was accorded thehigh honor of election to the Clinical So­ciety of Genito-urinary Surgeons at itsrecent annual meeting. Bill is chief ofurology at the Cook County Hospital, as­sociate professor of urology at Northwest­ern University, and senior attending urolo­gist at St. Luke's Hospital, Chicago,Eloise Parsons (Mrs. William J, Baker)is in practice in obstetrics and gynecologyand is on the staff at Chicago Lying-inand Women's and Children's Hospitals,She is president of the Board of Directorsof the Cancer Prevention Society of Chi­cago. Her research work on shock of twodecades ago in collaboration with Dr.Phemister is generally recognized as a veryimportant chapter in the story of shock,'25. Murray C. Eddy is proud of theclinic he organized in Hays, Kansas, fiveyears ago. Two other Rush alumni areassociated with the Eddy Clinic-A. M. Cherner, '37, and Philip J. Clark, '40, Dr.Eddy has confined his practice to generalsurgery since 1934,'27, Alexander Brunschwig, formerly amember of the surgical department at theUniversity of Chicago and now on thestaff of Memorial Hospital, New YorkCity, recently returned from India, wherehe had been called to perform specialsurgery.'29. George Earle Wakerlin and RuthBillings Coleman were married in Chicagoon February 14, 1952. Dr. Wakerlin is pro­fessor and chairman of the Department ofPhysiology at the University of IllinoisCollege of Medicine. Mrs. Wakerlin is thedaughter of George H. Coleman, 'I3, whois professor of medicine at NorthwesternUniversity and the president of the RushAlumni.'30. John Dorsey has recently beenappointed chief of surgery of the EvanstonHospital. He was formerly on the staff ofthe Presbyterian Hospital and assistantprofessor of surgery (Rush) of the Uni­versity of Illinois, He is a member of theChicago Surgical Society, Central SurgicalAssociation, and the American Associationfor Thoracic Surgery.Ralph H. Fouser is at Veterans Admin­istration Hospital in Little Rock, Arkansas.']I. Gene H. Kistler limits his practiceto general surgery with one associate. Heis chief of staff at Children's Hospital andattending surgeon at three local hospitalsin Chattanooga, He was certified by theAmerican Board of Surgery in 1944. Theeldest of the three Kistler children is inVanderbilt Medical School. Dr. Kistlergets to Chicago occasionally and we hopeto see him in June.Harold C. Wagner, formerly assistantprofessor of medicine at The Clinics, hasopened offices in the Woodlawn Clinic, onthe south side of Chicago,' for the practiceof allergy and internal medicine.'33. Eugene B. Schuster has been prac­ticing pediatrics in Pittsburgh since 1936;since September of 1950 he has been with­out an office and he says he enjoys thismanner of work especially-see them wherethey live.Erma A. Smith is assistant chief in theDepartment of Physical Medicine of theCushing Veterans Administration Hospitalin Framingham, Massachusetts.'34, Hollis F. Garrard is practicing der­matology and syphilology in Miami,August C. Orr has been in generalpractice, mainly obstetrics and pediatrics,for the past eleven years in Bismarck,North Dakota.'36, Joseph R. Stone left the Army in1946 to enter private practice of ortho­pedic surgery in Milwaukee, He is at pres­ent on the attending' staff of MilwaukeeCounty General Hospital and associateattending staff of Mount Sinai Hospitalin Milwaukee, He is a diplomate of theAmerican Board of Orthopaedic Surgery(1947) and a fellow in the American Acad­emy of Orthopaedic Surgery (1948), Harkins Named FirstRegional Vice- PresidentDr. Henry N. Harkins, Rush ']I, andfirst Ph.D, from the Department of Medi­cine of the University 'Of Chicago in 1928,is professor and chairman of the Depart­ment of Surgery at the University ofWashington. We are pleased to announcehis appointment as Regional Vice-Presi­dent of the Medical Alumni Associationof the Seattle area.This is the first of several such ap­pointments to be made in accordance withthe original provisions of the constitution.It is hoped that they will lead to the for­mation of local chapters of the AlumniAssociation composed of those who havea feeling of loyalty to the University ofChicago, an interest in its activities inmedical education and research, and de­votion to its standards of medical prac­tice.Dr. Harkins was resident and instructorin surgery at the University of ChicagoClinics from 1936 to 1938 when he joinedthe staff of the Henry Ford Hospital.Later he was associate professor of sur­gery at Johns Hopkins until 1947 whenhe went to the University of Washing.ton. He is a member of the Central Sur;gical Association, the Society of Univer­sity Surgeons, and the American SurgicalAssociation.'37. Jacob S. Aronoff has been ap­pointed clinical assistant professor of oto­laryngology at New York State UniversityCollege of Medicine,After a second hitch in the Air Force,Broda Barnes is now resuming privatepractice in Denver.Francis J. Phillips is medical directorand thoracic surgeon in the Seward Sana­torium, Bartlett, Alaska. The sanatoriumis operated by the women's division ofChristian service of the Methodist Church.It has 150 beds for tuberculous nativeAlaskans and there is no other doctor onthe resident staff. Dr. Phillips is also seniorsurgeon in Seward Clinic, part-time UnitedStates Public Health officer for the portof Seward, and a staff member of theAlaska Department of Health. In his sparetime he fishes and hunts-last summer helanded a 16-pound King salmon and inthe fall he killed a bull moose with anantler spread of 56 inches.Donald G. Stannus is practicing in­ternal medicine in Miami.'40. Ben D. Chinn is associate professorof bacteriology and public health ofGeorgetown University School of Medicine.'40. R. C. Vanderhoof specializes inophthalmology in Colorado Springs. TheVanderhoofs have just had their thirddaughter.MEDICAL ALUMNI BULLETIN 5)n November 29 and 30, 1951, a pro­m was held at Washington University1001 of Medicine by former studentsI associates in honor of Dr. Evarts A.aham on the occasion of his retirementBixby Professor of Surgery of Wash­ton University, St. Louis, Missouri.. Graham had held this position for 3 �irs having been called to the Univer­I in May, 1919, while he was still sta­ned at Fort Sheridan on active duty asIajor in the United States Army. Dur­these years at Washington Universitymade notable contributions in the fieldgeneral and thoracic surgery...Ie first gained international recogrn­n in 1924 when he, with Dr. WarrenIe, developed a method for roentgenualization of the gall bladder. Previousthis his investigation of the empyema.blem in 1918 led to the developmentprinciples which charted the course f?rdevelopment of thoracic surgery Inyears following World War I. In 1933revived interest in the surgical manage­nt of primary carcinoma of the lung by'orting the first successful total pneu­nectomy for that lesion.Ilotwithstanding these achievements,. Graham's greatest contribution has:n the development and inspiring ofmg surgeons.\ number of factors have played anrortant role in preparing Dr. Grahamhis life work. In 1901, when he was adent at Princeton, he decided on an for his career. Following medical001 and internship he had three objec­es=-to do major surgery, to engage inearch work, and to have a clinic ofmger men who would be interested. indying and developing ideas. Followingduation from Rush Medical College[907, and an intern year at Presbyte-1 Hospital, Chicago, Dr. Graham de-Eminent Surgeon Honored at Retirementviated from the usual course of surgicaltraining of that period by devoting sev­eral years to study in the basic sciences.During this period he benefited throughthe influence and inspiration of such menas R. T. Woodyatt (and indirectly Fried­rich Mueller), Hektoen, Le Coun.t, andWells. The effect of these associationsand this period of study is reflected inDr. Graham's outstanding accomplish­ments as an investigator, a teacher, anda surgeon.For his untiring efforts, ability andforthrightness he has received the highesthonors both in this country and abroad.Two of the more recent of these were theDistinguished Service Medal awarded bythe House of Delegates of the AmericanMedical Association in June, 1950, andthe Lister Medal of the Royal College ofSurgeons of England in 1947.Dr. Graham has occupied many re­sponsible positions in organized me�icineand surgery including the editorship ofthe Journal of Thoracic Surgery since1931; co-editor of Archives of Surgery,1920-1950; co-editor of Annals of Sur­gery, 1935-1945; editor of the Ye�r Bookof Surgery for many years. In addition heorganized and was the first chairman ofthe American Board of Surgery and amember of the National Board of MedicalExaminers for 9 years. He is a past presi­dent of the American College of Surgeons,American Association for Thoracic Sur­gery, the American Surgical Association,and the St. Louis Association of Surgeons.Dr. Graham possesses an unusual com­bination of talents. His early objectiveshave been more than accomplished. Hishigh ideals and principles will live onthrough the many young men who gainedinspiration from his teachings.WILLIAM E. ADAMS, M.D. PHEMISTER LECTURESAt the time of Dr. Phemister's re­tirement in 1947, the medical stu­dents undertook to institute a lec­tureship in his honor. Faculty andfriends asked to be included andfunds are now available to establisha series of Dallas B. Phemister Lec­tures.The inaugural lectures will be givenat 8 :00 P.M., October 2, at MandelHall. The occasion will introducethe twenty-fifth anniversary of TheClinics the success of which in nosmall part has been due to the intel­ligent foresight and devotion of Dr.Phemister.Dr. Evarts A. Graham and Dr.Alfred Blalock will give the firstlectures. They are two of surgery'sgreatest living men and were. twoof Dr. Phemister's most chenshedfriends.Dr. Phemister-[C ontinued from page 1]great suffering, in the early hours of themorning..Following cremation, the remains wereinterred in Oak Woods Cemetery in Chi­cago near the' University and the areawhich had been Dr. Phemister's home formost of his active life. A memorialservice, held on December 31 at theRockefeller Memorial Chapel, was at­tended by almost the entire personnelof the Clinics, by fellow members of thefaculty of the University of Chicago, andby other friends from near and far. Themourners who filled the chapel to paytheir respects to the memory of Dr.Phemister were gratified to hear theirown feelings expressed so beautifully inthe words of Chancellor Kimpton andDean Coggeshall.WALTER L. PALI>fER, M.D.6 MEDICAL ALUMNI BULLETINALUMNI NEWS'33. Israel A. Dinerman is now presi­dent of the Grafton County Medical So­ciety in Canaan, New Hampshire.Winston H. Tucker has been profes­sorial lecturer in public health, Depart­ment of Medicine, at Northwestern since1940. In 1950 he was president of the Illi­nois Association of Medical Health Officersand last year was president of the IllinoisPublic Health Association.'34. John L. Gedgoud, of Omaha, par­ticipated in the 48th annual meeting ofthe Wyoming State Medical Society atRock Springs, September 27-29. His sub­ject was "Fluid Balance."The first Meyer Bodansky lectures atthe University of Texas Medical Branch,Galveston, were given on February I.,.Carl F. and Gerty T. Cori, '947 NobelPrize winners, were the speakers. Dr. Bo­dansky was graduated from the Univer­sity in 1935. The lectureship was estab­lished by some Galveston businessmen inmemory of Dr. Bodansky who was pro­fessor of pathological chemistry.'36. Elizabeth Huff would like to seea New York chapter of the Medical Alum­ni established. Her address is 41 West 96thStreet, New York 25.Bernard Silber has joined a group inRedwood City, California, in internal med­icine. He is married and has three chil­dren and he says the combination keepshim busy.'37. E. L. Borkon and Mrs. Borkon (theformer Claire Binder) still reside in Car­bondale, Illinois, with two children-aa-year-old son and a daughter, 5. Dr.Borkon is the internist of a group (the firstof its kind in southern Illinois), of whomhalf are certified specialists.Everett 1. Evans, of Richmond, Vir­ginia, spoke at the annual session of theMedical Society of the District of Co­lumbia, October 1-3, on "Thermal andRadiation Injury in Atomic Warfare."Ormand C. Julian discussed "The Vas­cular System in Trauma" at a meeting ofthe Chicago Society of Industrial Medicineand Surgery on February 4.Leo Rangell was recently awarded theannual Clinical Essay Prize in psycho­analysis for 1951 in an international com­petition conducted by the British Instituteof Psychoanalysis in London.'38. Versa V. Cole, associate professorof pharmacology at Indiana UniversityMedical School since 1944, has acceptedan appointment in the department ofpharmacology, Army Medical Center, BelAir, Maryland.D. A. Glomset is a free-lance internistin Des Moines. He is associated with threeother diplomates of the Internal MedicineBoard in the practice of medicine and hesays it is indeed a happy and somewhatunusual type of partnership. In additionto the regular stipends they draw as part­ners, they pay themselves bonuses for arti­cles they get printed in' medical periodi­cals and speeches they give outside DesMoines-which helps to keep them fromfalling asleep between house calls. Francis B. Gordon is with the Chemi­cal Corps Biological Laboratories at CampDetrick, Frederick, Maryland. He saysthere are a number of other University ofChicago people there, including ClementBrooke, '48.David S. Pankratz writes that he isquite busy with plans for the new four­year medical school of the University ofMississippi to be built in ] ackson. Theyconsider themselves very fortunate to hiveDr. A. C. Bachrneyer as hospital consult­ant on their new project. Dr. Pankratzplans to be in Chicago in ] une for thereunion.'39. Ruth Barnard is still at the Men­ninger Clinic and enjoys it as much asever. She attended the Fourth Interna­tional Mental Health Congress in Mexicoand she hopes to get back to Chicagothis spring.Ruth Moulton (Mrs. Louis Gilbert)has three children: David, 9; Chris, 7;and Karen Elizabeth, 6 months. She isstill in private practice of psychoanalysisand does some teaching at Columbia­Presbyterian Medical Center and at Wil­liam Alanson White Institute of Psychia­try.'40. Horace lYL Gezon, who has beenon leave from the Department of Pedi­atrics for two years, is expected to com­plete his work with the Navy and returnto Chicago very soon.Gerald B. Macarthy is in general prac­tice in San Francisco. He is married andhas one child, a daughter, ] anice.Leonard A. Stine is practicing internalmedicine in Chicago and in Glencoe wherehe lives. He was certified by the Board ofInternal Medicine in 1950 and he teachesG-I at the Chicago Medical School. Heis also assistant attending physician atMichael Reese and a medical consultantto the new psychosomatic and psychiatricinstitute there.Randall L. Thompson is teaching atthe Indiana University Medical Center inIndianapolis. He writes that they haveqS medical students in each class. A newbasic science building is being planned toaccommodate their large enrollment. BillFreeman, '43, and Dwain Walcher, '40,are among the members of the staff fromChicago who are making splendid contri­butions to the development of the school.'41. Frank S. Gray is still doing gen­eral practice in Canajoharie, New York.He attended the fall meeting of the NewYork State Academy of General Practiceand he hopes to get to Chicago in ] unefor the reunion. He has two children­a boy and a girl.Theodore A. Hohm and his brother,Paul, '43, are practicing in a clinic inHuron, South Dakota, with two uncles.Ted does the medical work and Paul isthe surgeon. Ted writes that they are bothvitally interested in the University and itswork and every year they appreciate morethan before that they were once able toattend school on the Midway. He sendsgreetings to all their friends.William C. Lewis is in private practice of psychiatry in Madison, Wisconsin.commutes to Chicago for work atInstitute for Psychoanalysis. He is csultant in psychiatry to the new VeterAdministration Hospital in Madisonto the Lakeview Tuberculosis SanatcriiHe and his family, which now inclufive boys, live in the country in amodeled farmhouse with three acrestheir own and enjoy life very much.Lewis was associated with the MenninClinic in Topeka from 1946 to 1\passed the psychiatry boards in 1948, ;had three years of psychoanalytic trainin Topeka.Gene T. Richardson is practicing UIogy in the Imperial Valley, at El CentCalifornia.Frederick J. Stare writes that hehis hands full trying to run the Depament of Nutrition at Harvard SchoolPublic Health. He has a staff of ab.sixty, including graduate students andsistants. They all want to work on thown problems and they all want rn.space and more equipment and theywant more money. He expects to beChicago in ] une for the Alumni Reun.and the A.M.A. meetings.'Walter A. Stryker is president ofMichigan Pathological Society and in I'was president of the medical staffWyandotte General Hospital. He is nassociate professor of pathology at Wa:University College of Medicine.'42. Ralph W. Barris is now asscated with Dr. Charles W. SuIt of La ]0California, in the private practice of nrology.D. H. Cahoon has, for six montbeen associated with the Marshall eliin his home town of Roswell, New Mico. He completed all the requirementsboard membership in internal' medicwhile he was in the Air Force from whhe retired last year.Albert F. Fricke is in private prac:(internal medicine) in ] acksonville, 1nois, and is enjoying it immensely.Robert R. Morris is in the privpractice of psychiatry in San· FrancisHis first child, a boy, was born in A�1950.Joseph Ransohoff is still practicing nrosurgery at Columbia P & Sand ]'.York Neurological Institute. He says h.beginning to do more pediatric than acneuros and is working on new operatifor hydrocephalies, etc. He has seen fvey Blank several times and reports the is doing a fine job at Squibb's asof their research directors.'43. Jay P. Bartlett reports on the Iversity of Chicago colony in Ogden, U'Russel Nichols, Rush '37, is doing'in roentgenology at T. D. Dee MemcHospital. He has a home for his faras soon as they can sell their house in (cago. C. C. Maher, ]r., '45, can be fofishing, hunting, or touring any Thursafternoon, or early any morning. 'Mahers expect an addition to their farrmaking six in all. Ralph Myers and l'Huckleberry, '45, he sees occasion:MEDICAL ALUMNI BULLETIN 7The Bartletts' doormat Welcome is outto any western explorers.Arthur Connor is chief resident inorthopedics in Worthington, Ohio.LaRele J. Stephens has recently limitedhis practice in Moscow, Idaho, to obstet­rics and diseases of women. His familyhas grown to three-two boys and a girl.William Stone will complete his resi­dency in anesthesiology at the Universityof Utah School of Medicine this springand then put Uncle Sam's nephews tosleep again. He sees Chet Powell quiteoften.'44. Edward G. Ference of Springfield,Illinois, is being recalled to active militaryduty in tbe 44th Infantry Division withthe rank of Major.Charles Gabelman writes that he isjust really getting a grip on private prac­tice. He has opened a new office for thepractice of internal medicine. It isn't easyin Denver because there are a great manydoctors there, but he is enjoying it. Hesees a good many Chicago people-Dr.Eisele, who is very fond of the town andclimate; Dr. Lanier, Dr. Wendell Stamp­Hi, who is head roentgenologist at St.Luke's Hospital in Denver, Dr. Abe Kau­var, '39, who is with a well-establishedgroup, and Dr. Robert Weaver, '44, whois in pediatrics. Dr. Gabelman wants usto reserve a place in the medical schoolfor Charles III in 1972.John W. Karn for the past two yearshas restricted his practice to anesthesi­ology in a private practice-partnershipgroup in South Bend. He now has twochildren-a son, John W., j r., 5 years old,and a daughter, Joanne Elizabeth, nearlya year. He's looking forward to a classreunion.Neil B. Kimerer is the only full-timepsychiatrist at the University of OklahomaMedical School. He reports that HowardHopps from Chicago is chairman of thedepartment of pathology there and thatFlorence Kelly is in bacteriology, but hedoesn't know of any other alumni in Okla­homa City. His family has increased tofour children.Lee Pearce is G. C. Leach fellow inmedicine at Johns Hopkins Hospital. Heis working on the dye dilution cardiacoutput and central volume problem as wellas metabolic factors in heart failure andvectorcardiography. He hopes to get toChicago in June.Charles W. Schlageter passed hisboards in psychiatry last June. He hasa private practice of psychiatry, workswith the Veterans Administration at Hines,and teaches at the University of IllinoisMedical School.'45. J. A. Aalpoel is in the Army, atpresent with a Mobile Army Surgical Hos­pital in Korea, as a surgeon. He has beenwith the Army since last June and ar­rived in Korea in mid-August.Thomas W. Anderson is in the privatepractice of ophthalmology in Seattle,Washington.Frank Brooks has offices in Deerfieldand Highland Park, Illinois. He says thereis nothing like being in business for your­self, where you are your own boss. He'sdoing general practice and loves being the"L.M.D."Marne Cataldo finished his medicalresidency last July and is at present prac­ticing internal medicine in Oak Park, Illi- nois. He is instructor in medicine at theUniversity of Illinois Medical School andalso associate attending man to the medi­cal staff at Cook County Hospital. He is,in addition, medical examiner for PeoplesGas Light and Coke Company of Chicago.Robert E. Cook is a resident in neurol­ogy at Baltimore City Hospital and moveson to Johns Hopkins Hospital next July.T. G. Harward sends word of havingseen Stanley Moulton, '45, John Par­tridge, '45, Ray Goodman, '44, at theA.M.A. convention in Los Angeles. Moul­ton is all set up for G. U. work in Cren­shaw; Goodman is with U.C.L.A. untilJune; Partridge is still in research atHighland in Oakland with no plans ofchange. Harward and his family are allwell and he is still in general practice inNeedles, California, and he also plans nochange.Stanley Moulton has been in his ownoffice since September, practice limited tourology, and he is the urologist in amedical center of about fifty men-allindependent.Anthony Pizzo is now practicing pa­thologist in Bloomington and Bedford,Indiana. He teaches part time at the Indi­ana University Medical School. His son,Andy, is now 4 years old, Christopher is2 and a half, and they expect a baby thisspring.John R. Russell has a full-time ap­pointment at Indiana University Schoolof Medicine, instructor in neurosurgery.Louis B. Thomas is spending a year atMayo Clinic in neuropathology.I van Cyril Tiholiz reports that inNorthridge, California, where he prac­tices, Stan Moulton, '45, does his urology,and he refers his tough internal medicalproblems to Omar Fareed, '44. He has ason, John, and a daughter, Susan.Everett van Reken was dischargedfrom the Army last August, having spenttwo years in the service-one and one­half years at Wright-Patterson Air ForceBase in Dayton, and six months in Ft.Campbell, Kentucky, where the r r th Air­borne Division is stationed. On Novem­ber 19, 1951, he began practicing in theOak Park-Cicero-Berwyn area where hetook over the practice of a physician whoretired. The practice is good and helikes it.'46. John H. Donnelly for over twoyears has been in private practice in Por­tales, New Mexico, doing general medicinewith emphasis on pediatrics. He is activein the Curry-Roosevelt County MedicalSociety, is associate member of the NewMexico Pediatric Society, office in the localJunior Chamber of Commerce, and isbuilding a model railroad empire as ahobby.Lt. Richard S. Farr is stationed atNa val Medical Research Institute in Be­thesda, Maryland, and likes it very much.Julien H. Isaacs has left Chicago andopened an office in Los Angeles for theprivate practice of internal medicine.Jack E. Kahoun has opened his officein San Mateo, California, for the practiceof internal medicine. His family now in­cludes Bruce, 4, Laura, 2, and Susan, sixmonths. They all thrive in the peninsulaweather.John S. Kozy is acting chief of themedical service in the U.S.P.H.S. Hospitalin Ft. Worth, Texas, a rooo-bed hospital devoted exclusively to the treatment ofneuropsychiatric cases and drug addiction.His duties center around the physical illsof the patients-there are ten psychiatriststo worry about the psychiatric problems.The Kozys now have three sons and theyall enjoy living in Texas.John A. Sibley is doing urology in the97th General Hospital at Frankfurt, Ger­many. He is reported to be living in thelap of luxury-a o-room house, two orthree servants, and 12 If gasoline. Tough,our correspondent says.Floyd S. Stancliffe is in general prac­tice in Superior, Montana, and MineralCounty. He is Mineral County physicianand health officer and physician and sur­geon for the Milwaukee Railroad, North­ern Pacific Railroad, and the DiamondMatch Company.'47. J. R. Barberio, after interning withDr. Harry H. LeVeen at New York Uni­versity, spent two years on active dutywith the Navy, working in the experi­mental surgical section at the Naval Medi­cal Research Institute, Bethesda, Mary­land. He was discharged last summer andhas been a National Cancer Institutetrainee in surgery at the George Washing­ton University Cancer Clinic in D.C. Heexpects to complete his general surgicaltraining in the George Washington Uni­versity program. Bill Smith was at NMRIat the same time and is now at Mayo'sin surgery. Merrill Nelson is at GeorgeWashington University Hospital, havingjust recently returned from duty in Korea.Kenneth M. Campione is at presenton duty with the U.S. Air Force, assignedto the 36th Fighter-Bomber Wing in Ba­varia. He says opportunity for medicalexperience is excellent and he is also ableto see many interesting places in Europe.Capt. Max E. Griffin is chief of de­pendents' service at Camp Breckenridge,Kentucky.Ruth Heyn is instructor in pediatricsat the University of Michigan.Gerald Hill is in private practice ofpsychiatry in Detroit, after having com­pleted his residency at the University Hos­pital, Ann Arbor. He hopes to be in Chi­cago at the reunion in June.Hal T. Hurn is on the psychiatric staffat the U.S. Navy Hospital, Great Lakes,Illinois.Frank B. Kelly, Jr., is senior assistantresident in medicine at Georgetown Uni­versity Hospital, Washington, D.C. Heplans to start in private practice in Julysomewhere in the Middle West.William L. Lorton has been in theArmy since June, 1951, and is now over­seas.Frank T. Lossy is still at Tulane on afellowship in the Department of Psy­chiatry.Harry A. Oberhelman, Jr., is in theAir Force, permanently assigned to Good­fellow Air Force Base, Texas. in surgery.He is at present attending the AviationMedical Examiners' (Flight Surgeons)course at the School of Aviation Medi­cine, Randolph A.F.C.. Texas. His familyis with him.Irving H. Rozenfeld is chief of pedi­atrics. U.S.A.F. Hospital, Rinker Air ForceBase. Oklahoma Cit,'. Ed Long is chiefof the surgical service there.[Coltlillurd on pagl' 1518 MEDICAL ALUMNI BULLETINS C IE NT I F I C SECTIONFurther Studies on the Inactiva­tion of Anti-Diuretic Hormoneby the Blood of Pregnant WomenBy CHARLES P. MCCARTNEY, M.D.Obstetrics and GynecologyDieckmann reported in 1950 thatblood obtained from individuals in thelast half of pregnancy upon being in­cubated with Pitressin will inactivatethe anti-diuretic effect of this substance.In studying 110 individuals relative tothis inactivation phenomenon, we con­firmed Dieckmann's observation, and inaddition found that this inactivatingability was consistently present in gesta­tions of 18 or' more weeks' duration. wasconsistently absent in gestations of 10or less weeks' duration, and was variablein each gestational group from I I to 17weeks inclusive.No significant qualitative differencein respect to this inactivating abilitywas noted in individuals with preeclamp­sia-eclampsia as compared with normalpregnant individuals. It was found thatadsorption by formed elements of theblood of these individuals was not afactor in this activation, and evidencewas obtained to indicate that this inac­tivating substance does not cross theplacental barrier.This phenomenon has potential sig­nificance in that its investigation froma quantitative standpoint which is nowbeing carried out may clarify the rela­tionship between the rate of ADH in­activation and the marked retention ofwater and electrolytes and the inabilityto excrete ingested water at a normalrate which is present in preeclampsia­eclampsia.Effect of ACTH upon InducedLeukemia in DBA MiceBy MATTHEW BLOCK, M.D.MedicineMice, after induction of leukemia bypainting with methylcholanthrene, weredivided into three groups. Group I (24mice) was injected with o. I mg. ofACTH in saline three times daily, groupII (IS mice) was similarly injected withsaline, and group III (10 mice) was un­treated. All survivors were sacrificed at2 r days.There was no significant difference inwhite and differential counts between thethree groups. Survival time was not sig­nificantly altered by treatment. ACTHtreated animals had a much higher in­cidence of infection which undoubtedlycontributed to the mortality rate of thisgroup. Nevertheless, these animalsseemed better nourished and more ac- tive. The tissues of all animals dyingduring the first 14 days were similar.In group I, I of 3 animals at [4 to 17days, I of 2 at 18 to 20 days and 5 of 8at 2 I days showed histologic evidence ofregression of their leukemia and thedevelopment of myeloid metaplasia inliver and spleen. In group II, r of 3animals at 14 to 17 days and r of 5 at2 I days showed some questionable evi­dence of a similar change. One of 10animals in group III had a regression ofleukemia.Arterial Oxygen Saturation 10Newborn InfantsBy KLARA PREC, M.D., andDONALD CASSELS, M.D.PediatricsThe greatest changes which take placeduring the transition from fetal life tonewborn infancy are those related tocirculation and respiration. During thistransition from parasitic to independentexistence, nonfunctioning lungs becomefunctional, and blood which had beendiverted from the lung must acquire aproper pulmonary flow for adequate oxy­gen transport to the tissues. While themore gradual anatomical changes whichestablish new blood-flow patterns havebeen studied extensively, little informa­tion is available concerning the earlyfunctional hemodynamics. This problemcan be approached indirectly by a studyof changes in arterial oxygen saturation,since the fetal circulation requires shunt­ing of blood from the right heart to theleft and persistence of this shunt shouldbe reflected in changes in peripheral sat­uration.The arterial oxygen saturation wasdetermined in I 3 5 normal newborn in­fants in the nurseries of the ChicagoLying-in Hospital by the use of a singlescale absolute reading oximeter and amodified Coleman earpiece (which hasbeen found to be sufficiently accuratein the range of saturation involved inthis study). While the saturation risesto normal values shortly after birth,oxygen saturation during crying is dif­ferent in infants under four days of agefrom that in older infants. In the youngergroup, oxygen saturation decreases dur­ing crying in contrast to an increase inthe group over four days of age. Sincethis pattern of response persists duringadministration of oxygen, the diminu­tion of saturation cannot be attributedto inadequate pulmonary function. Thisfall in oxygen saturation in the earlynewborn period is believed to representa functional venous-arterial shuntthrough an anatomically patent foramenovale, occurring when the pressure gra- dient between the auricles is reversed lthe involuntary maneuver associatewith crying.The evidence suggests that the for.men ovale functionally closes, as far;can be determined -by indirect evidencduring the first three days of life. Hovever, the centuries-old debate concening neo-natal circulatory changes can 1ended only by direct pressure-recordirin appropriate positions in the .cardi,vascular system.Enzymatic Cytolysis ofEpithelium by Filtrates ofFeces from Patients withUlcerative ColitisBy RICHARD B. STOUGHTON, M.D.Dermatolo gyWhile exploring the effects of a nunber of proteolytic enzymes on hum"skin, it was observed that filtrates Ifeces from patients with ulcerative coltis induced striking changes in epithelicells. The effect is mainly on the cyt.plasm which becomes pale-staining arthen dissolves away; another earchange is the loss of intercellular prot,plasmic bridges. So far this factor h,been found only in the feces of patienwith ulcerative colitis and not in nomal feces.A buffered filtrate is made from Iresulcerative colitis feces and this is addeto sections of skin or of colon, and thethe preparation is incubated at 370 4from one to two hours. After this tlsections are washed and stained wi:haematoxylin and eosin. Sections ,colon are more resistant to digesticthan skin sections.Skin sections fixed with acetone shoa loss of staining of the epithelium arlysis of cytoplasm, a process similar Itryptic digestion. The factor causing thlysis is relatively stable and will witlstand room temperature for some dayWith formalin-fixed sections therea loss of intercellular bridges betweethe epidermal cells, which become sep.rated so that the epidermis disintegrateThis factor seems to be separate frothat which affects acetone-fixed sectioiand is far more heat-labile. Its sensitivty to heat, to certain metals, and 1acidity, and its inhibition by serum, suogest that this is an enzyme. A numb,of known proteolytic enzymes have !far failed to produce these specific efects on formalin-fixed skin. The effeof the fecal filtrate on skin producespicture reminiscent of that which we 51histologically in Pemphigus vulgaris. Posibly such an enzyme may play a pain the pathogenesis either of ulcerati­colitis or of pemphigus.MEDICAL ALUMNI BULLETIN 9The Biosynthesis ofHyaluronic Acid by Strepto­coccus HemolyticusY SAUL ROSEMAN, PhD., FRANCES E.MOSES, B.S., ROBERT ABELES, M.S.,JULIO LUDOWIEG, M.S., andALBERT DORFMAN, M.D.Pediatrics and BiochemistryThe mechanism of synthesis of muco­nlysaccharides is unknown. This reportconcerned with the biosynthesis ofyaluronic acid by a strain of Group Areptococcus. Dvglucose-r-C"! was in­irporated into a semisynthetic mediumBernheimer, A. W., and Pappenheimer," M., J. Bact. 43, 481(1942)] and,fter growth of the organism, hyaluroniccid was isolated from the supernatantiedium utilizing phosphomolybdic acid5 a protein precipitant. The hyaluroniccid was hydrolyzed and CO� (whichspresents the C(; of glucuronic acid)'as liberated and collected, Glucosamineydrochloride was isolated from the hy­rolysate by treatment with Dowex I,allowed by conversion to the hydroxy­aphthaldehyde Schiff base [jolles, Z. E.,nd Morgan, W, T, J., Biochern. J, 34.184(1940)] and partition chromatogra­,hy of the base on silica gel. Suitableontrol experiments demonstrated thathis procedure yields glucosamine hydro­hloride free from trace amino acidontamination. A method was developedor the degradation of glucosamine con­isting of oxidation to glucosaminic acidnd treatment with ninhydrin or chlora­nine-T to yield CO2 (from C1) andrabinose. The results obtained indicatedhat the major fraction of the radio­ictivity of the glucosamine was presentn C-1. These data suggest that theiucosamine moiety of the hyaluroniccid arises from glucose. (This investi­ation was supported by a grant from�e United States Public Health Service.)lome Epidemiological and Clio­cal Aspects of Pulmonary His­toplasmosis in a Farm FamilyBy CLAYTON G. LOOSLI, M.D.,J. THOMAS GRAYSTON, M.D"FAUSTO TANZI, M.D.,and E. RUSSELL ALEXANDERPreventive AI edicinePulmonary histoplasma fungus infec­.ons in six members of a farm familyE) have been observed over a periodf fifteen months, These infections aref interest in that they demonstrate theide range of severity and varied mani­stations of the disease, They ranged'om the clinically inapparent infection,ith or without calcification in the lungs,I the clinically severe illness involvingmeral dissemination of the fungus inre host. Mr. E, the father, represents an etio­logically proved case of generalized his­toplasmosis with extensive pulmonaryinvolvement where the patient surviveda long and protracted illness and is nowafter fifteen months in apparent goodhealth, Although the fungus was notisolated in the cases of the two sons,the similar onset of illness, chest find­ings, significantly high complement-fix­ing antibodies, and positive skin teststo histoplasmin antigen undoubtedlyclassify them as cases of extensive pul­monary histoplasmosis which are atpresent in apparent good health. Thepulmonary findings are of interest inthat the lesions in the case of AE Jr.,age st and EE, age 23, now show ex­tensive calcification whereas those ofthe father are just beginning to showflecks of calcium by X-ray.The father and his two sons in allprobability acquired their infections asa result of the inhalation of dust con­taining H, capsulatum when they re­moved about two feet of sawdust froma silo which had been used several yearspreviously as an ice house, H. capsul­atum has been isolated repeatedly dur­ing ten different monthly surveys froma relatively large number of samples ofresidual soil from the silo floor and wall.The source of the fungus causing theafebrile illnesses was not accurately de­termined.This study of pulmonary histoplasmo­sis in a farm family represents the firstwhere the source of the fungus causingthe illness was determined, It furthershows the close relationship of the be­nign infections to the clinical febrilecases, a relationship which up to nowhas not been appreciated generally.Cochlear ResearchBy HAROLD F. SCHUKNECHT, M.D,OtolaryngologyFor many years, two contradictory ex­planations of pitch discrimination weremaintained and defended but neitheradequately accounted for the physiolo­gical and anatomical facts. Accordingto the "place theory," pitch is deter­mined by the location of vibrations onthe basilar membrane. Anatomicalstudies, however, have failed to supportthe idea of critically resonant structuressuch as would be necessary for pitchdiscrimination as we know it. Further­more, the existence of isolated resonat­ing areas is incompatible with the highdegree of dampening created by thecochlear fluids, The "frequency theory"maintained, on the other hand, that pitchis independent of locus. but is deter­mined by the frequency of impulses car­ried by the individual nerve fibers. Thisidea in its pure form is not acceptablebecause a single nerve fiber can trans­mit only a few hundred impulses per second and cannot by itself attain ratesin the thousands. The inadequacies ofthe individual nerve fiber in this respectled to the volley principle, which, how­ever, is itself not fully adequate. Ac­cording to this explanation, for highfrequencies each fiber responds to cer­tain of the sound waves, and the fullfrequency is represented by the com­bined action of many fibers.By making limited use. of both theplace and frequency theories and incor­porating the volley principle, the "pat­tern theory" of auditory perception hasbeen conceived. According to this moreacceptable idea, an auditory stimuluscreates a vibratory response over anarea of the basilar membrane and itsorgan of Corti according to the regionalvibratorv characteristics of the struc­ture. Accordingly low tones create adisturbance in the apical end and hightones at the basal end; in either casethe response is spread out so that agroup of neural and sensory elementsare excited. The "pattern theory" there­fore implies that pitch has a two-foldrepresentation, first in terms of placeon the basilar membrane and thereforeof excitation of a selected group ofnerve fibers, and, second, in terms ofthe composite impulse frequency in thesenerve fibers.In order to determine more accuratelythe role of "place" in pitch perception,surgical procedures were developed sothat restricted lesions could be made inthe apical and basal ends of the cochleasof cats. These animals were sound con­ditioned so that hearing tests could bemade on them. After post-operativeaudiograms were obtained the animalswere sacrificed and the inner ears weregraphically reconstructed. The locus andextent of pathology were correlated withthe hearing test for each ear.The results from the experiments onthe apical end of the cochlea indicatethat, at near threshold intensities, fre­quencies below 500 C.p.s. excite neuralreceptors only in the apical turn of thecochlea. As intensity is increased thelow frequencies appear to arouse activityover a wide area of the cochlea so that,at intensities of 20 to 30 db. abovethreshold, they produce excitation atleast as far towards the base as thelower middle turn of the cochlea.Lesions of the basal coil, on the otherhand, produce high tone hearing losseswhich are relatively more severe forthe involved frequencies but are morerestricted within the frequency scale.Therefore the response patterns (capa­ble of producing neural excitation) arerelatively broader in the apex for lowfrequencies and narrower in the base forhigh frequencies. The findings are ingeneral agreement with recent electro­physiological and physica l measurementsof the cochlea made by others.10 MEDICAL ALUMNI BULLETINCAT 3In the figure is the cochlear chart andaudio.gram for a cat with an apicallesion, The black filling in the threeparallel channels indicates the percent­age of normal elements remaining forhair cells, nerve fibers, .and ganglio.n cellsrespectively. The numbers beneath thesebars indicate the distance in millimetersfro.m the basal end of the co.chlea. Theaudio.gram is plo.tted in such a way thatthe vario.us frequencies fall ro.ughly into.their proper location abo.ve the co.chlearchart (as determined by previo.us ex­penments). The o.rdinate indicates deci­bels of hearing lo.ss. In this animal ato.tal loss of neural elements in the api­cal 6 mm. of the co.chlea has createdabout 30 db. hearing loss Ior frequenciesfrom I 25 �o. 2000 c.p.S. at an intensityof 30 decibels. These low frequenciesare apparently capable of exciting neuralelements as low as the r a-mm. area.Experimental Studiesin Chronic (Hepatic) PorphyriaBy CALVIN]' DILLAHA, M.D., andWILLIAM HICKLIN, B.S., M.A.DermatologyIt has been repo.rted that largeamo.unts of crude liver extract adminis­tered intramuscularly appreciably re­duce? the urinary and fecal copropor­phynn excretio.n in two. cases o.f co.n­genital po.rphyria. This was asso.ciatedwith clinical impro.vement. Ho.wever,because the amo.unt of liver extractnecessary to. pro.duce impro.vement wasvery large, it was not feasible to. co.ntinueit except for a sho.rt perio.d. Oral liverextract was ineffective.. The isolation of Vitamin BI� as animportant facto.r in liver extractprompted us to. evaluate its effect onpo.rphyria since large amo.unts co.uld begiven o.ver long perio.ds of time.To. carry out such a metabo.lic studymetho.ds of analysis of urine and feces for uro.po.rphyrin and co.pro.po.rphyrin ona day-to.-day basis were develo.ped.Our study was with a 49-year-o.ldwo.man with hepatic po.rphyria manifestby the excretio.n of large amo.unts ofcopro- and uro.po.rphyrin in the fecesand urine, and by hypertricho.sis offace, pigmentation of expo.sed skin. andthe appeara�ce of bullae on her fingersfollowing mild trauma. The patient hadregularly co.nsumed one or two. co.ck­tails every evening Ior o.ver twentyyears.For this study the patient was ho.spi­tahz�d on the Metabo.lic Study ward 'ona diet co.ntaining a fixed co.ntent ofmeat and a constant fluid intake. Thealcoholic intake was sto.pped at this timealso. Under the abo.ve-mentio.ned co.n­ditions, the daily urinary co.pro.po.rphy­nn ranged between .71 mg. and 040 mg.With an average of 048 mg. The uro.­po.rphyrin ranged between '9.3 mg. and5.8 mg. with an average of 7.23 mg.This was during a two. weeks' controlperio.d. (No.rmal urine co.ntains 50-250gamma per 24 hours o.f coproporphyrinand no. detectable uro.po.rphyrin.)Subsequently with the administratio.no.f vitamin B12, 120 gamma per day Ior17 days, the urinary co.pro.po.rphyrin anduropo.rphyrin gradually declined o.ver aperio.d of 17 days to. a level significantlylower than during the control perio.d.A.fter t?is perio.d of therapy the B 12 wasdiscontinued. Po.rphyrin excretio.n con­tinued to. fall for several days and thenro.se. again but not to. the previo.us levels.Again BI2 was administered and againthe urinary po.rphyrin excretio.n declined.During this seco.nd perio.d of therapyfecal uro- and coproporphyrin determi­natio.ns were carried o.ut. It was co.nsid­ered po.s.sible that the decrease in urinaryporphyrin excretion was a reflectio.n ofthe liver's enhanced ability to. excretepo.rphyrin in the feces. The fecal por­phyrins did not increase, ho.wever, butrather the coproporphyrin decreased andthe uropo.rphyrin remained co.nstant.Co.ntinue� administratio.n of oral BJ2and estimation o.f urinary po.rphyrin ex­cretio.n during the next several monthsshow that the po.rphyrin excretio.n hasg.radually �allen until the coproporphy­nn level IS within normal limits andthat the uro.po.rphyrin level is less' than100 gamma per day.Clinically this patient has shown muchimpro.vement in her general well being.The hypertrichosis has subsided andthere have been no. bullae for the pastyear.MAKE RESERVATIONS FORTHE BANQUETNOW Effect of ACTH and Cortiscon Experimental BurnsBy E. R. WOODWARD, M.D.,JosE ZUBIRAN, M.D.,ALAN KARK, M.D.,ANTONIO MENTALBETTI, M.D ..and WILLIAM B. NEAL, M.D.'SurgeryDeath co.ntinues to. occur after nsive burns despite seemingly adeqireplacement of blood and electrolyThe role of the adrenal gland inburn mortality has been speculated uextensively. The ability of adrenal-c.cal extracts and cortisone to enableadrenalectomized animal to. withstcertain stresses (work, cold,. andpho.id vaccine) is not accompanieda similar ability to protect the inanimal against limb ligatio.n, radiatetc. Indeed, evidence to the contraryaccumulated, altho.ugh it has beenknown that follo.wing a stress situathe adrenal gland becomes depleteccholestero.l and ascorbic acid and suquently in a matter of a few hourshibits a marked hyperplasia, as ifaugmented production of cortical Imones were an impo.rtant protecmechanism. Because of this andcause, recently, there have been ciathat the proper way to treat burns (o.ther surgical traumata) is toACTH or co.rtiso.ne to the therapy,were led to study the effect of AC'cortisone and desoxycorticosterone :tate on burn mo.rtality in the laborat.White, male rats, weighing apprmately I So grams, have been burnedimmersing their do.rsal surfaces in w:of 85° C. for 30 seco.nds. The areaburned has been quite co.nsistently at30% of the total body surface. Usingstandard burn pro.cedure we have stied the effect on the mortality ofrna Is so. burned: of no. treatment Jmal saline given as 10% of the' bweight at l,he time of burning, adrecorticotroprc hormone given both belburning and after burning,' cortistand-desoxycorticosterone acetate, FIthe several experiments already dwe have concluded the follo.wing.have co.nhrmed Rosenthal's demonstion of, the remarkable ability of hquantities of normal saline solutionprotect the burned animal. Neither ccsorie nor ACTH given after a burrhave, in the do.ses used increasedeffecti veness of normal' saline. Tldrugs, given without saline, have fato. demo.nstrate any protective actCortiso.ne given before a burninggreatly increased the mortality ofburned rats. Desoxycortico.sterone ,tate has exhibited a marked effective:in pro.tecting the burned rat. Howedesoxycorticosterone acetate has 'added anything to the protective eliof normal saline given alo.ne at the t:of burning.MEDICAL ALUMNI BULLETIN 11Constitutional Abnormalities ofCarbohydrate Metabolism inPatients with RecalcitrantFungus InfectionsBy EUGENE]' VAN SCOTT, M.D., andSTEPHEN ROTHMAN, M.D.DermatologyInfection of the palms, soles, and nailsby the filamentous fungus Trichophytonrub rum is a disease resisting all kinds oflocal treatment, including all availablefungistatic agents. This is odd becausethe fungus is quite susceptible to theseagents in vitro. Inasmuch as relativelyfew persons are prone to contract in­fections of this fungus, and rarely trans­fer the infection to another person, itwould appear that there is a rather spe­cific susceptibility factor in these indi­viduals which at the same time does notallow eradication of the fungus fromthe skin by any of the usual fungistaticcompounds.Several years ago a detailed labora­tory work-up of an individual with anextensive infection with T. rub rum re­vealed him to have a flat glucose toler­ance curve. Because of this finding glu­cose tolerance tests were recently per­formed on a total of twenty cases of thisinfection. The curves of these testsshowed twelve of them to be unusuallyfiat or at the lower limits of normal,seven were within normal limits, andone was slightly elevated.The number of low curves was statis­tically unusual and perhaps offered a clueto why the fungus flourishes so well inthe skin of individuals so infected. At­tempts to raise the glucose tolerancecurves were made with thyroid medi­cation. The fungus infections improvedbut no case was entirely cleared of theinfection.There are data available indicatingthat fungistatic agents inhibit growth offungi by interfering with their carbohy­drate metabolism. Consistent with thisis our finding that the fungus, whenbred on pure peptone media, is aboutfour times more resistant to fungistaticagents than when it is bred on regularglucose-peptone media.Fungi preferentially metabolize glu­cose, but if glucose is not available theymay adapt themselves to utilizing nitrog­enous material. It is feasible that asimilar situation prevails with fungi in.he skin of persons with flat glucose tol­erance curves. These fungi may be re­.istant to fungistatic agents because theylave learned to metabolize nitrogenousnaterial, the fungistatic agents beingmabie to interfere with this metabolism.. lhis hypothesis is now being tested. Listermates. The center allimal is normal; the other two are cretinsPhysiological Studiesin Experimental CretinismBy A. E. KARK, M.D., J. M. ZUBIRAN,M.D., and L. R. DRAGSTEDT, M.D.SurgeryWith the use of radioactive Jl3l cre­tinism has been produced in dogs. Thismethod avoids the difficulties of surgicalmethods where frequently simultaneousremoval of parathyroids causes death bytetany.The technique for inducing an athy­roid state has been standardized by giv­ing 3-day-old pups 0.5 mc. p3l subcu­taneously and repeating this dose atmonthly intervals for a course of 3doses. A pup receiving 0.5 mc. at 10 daysold will not show nearly so profound aneffect. Another method used is to give apregnant bitch 15 mc. Jl3l during thelast week of pregnancy. However thelatter method allows for no control pups.The study includes a general descrip­tion of athyroid dogs, changes in bloodchemistry, radiological differences, andthe effects of feeding various thyroidpreparations. To obviate the variationsin weight, size, and appearance of mon­grel litters, standard breeds of Stafford­shire Bull Terriers are now being raised.The material now includes (a) onecretin dog 26 months old; (b) a litter of4 cretin dogs aged 2 years and 2 cretinsaged 2 years, both litters having had thethyroid destroyed ante-natally; (c) alitter of 8 Staffordshire Bull Terriersaged 9 months, 6 of which were in­jected during the first week of life; (d)a litter of 5 Staffordshire Bull Terriers,4 of which were injected with Jl31 in thefirst week; (e) a mongrel litter of 5 pups,4 of which were given Jl3l on the first dayof life; and (f) two 2-month-old pups, themother having been given 15 mc. p:H 35days after pregnancy had started, i.e. justbeyond the half-way stage of pregnancy.A general description of the animalsincludes the growth changes, the dry, wrinkled skin, and the early developmentof prognathism. Alteration in radiologi­cal appearances is marked, particularlythe retardation of epiphyseal appearanceand subsequent closure.The blood chemistry shows a rise inserum lipids and serum cholesterol, whileblood sugar and calcium remain normal.Endocrine changes include inactiveovaries and testes with some enlargementof the pituitary.The effects of feeding various thyroidpreparations are being watched.Other work in progress includes thepart played by the maternal and foetalthyroid during pregnancy. An athyroiddog fed on desiccated thyroid has beenbred and has whelped pups. At presentthe earliest injection of Jl31 in a preg­nant bitch which carried on a normallength pregnancy was at 35 days. Thistime period is being varied to determinethe time of uptake by foetal thyroid ofJl31.The Histopathologic Effects ofACTH or Cortisone in Patientswith LymphomasBy MATTHEW BLOCK, PH.D., M.D., andLEON O. JACOBSON, M.D.MedicineTwenty-one cases of lymphomas, pri­marily acute leukemia, have been treatedwith ACTH or cortisone. About two­thirds were benefited-the highest per­centage of remissions occurring in acuteleukemia. The patients had biopsies ofthe marrow and in some cases of liver,spleen, and lymph nodes. In each case acontrol biopsy was obtained immediate­ly prior to treatment and further biop­sies as frequently as possible thereafter.In general the most marked histolog­ical changes were seen in the patientswho developed a clinical remission.These changes were particularly promi­nent in patients with acute leukemia and[ Continued on page 14112 MEDICAL ALUMNI BULLETINFACULTY NEWSDrs. Leo Abood, Ralph Gerard, JohnPerkins, and Robert Tschirgi took partin a meeting of the American Physiolog­ical Society in Salt Lake City in Sep­tember.Dr. William E. Adams talked beforethe Black Hawk County Medical Societyin Waterloo, Iowa, on January IS. OnNovember 29 he spoke on "The use ofparaffin for obliteration of the pleuralspace following pneumonectomy" at theprogram honoring Dr. Evarts Graham onthe occasion of his retirement at Wash­ington University, St. Louis. Dr. Adamsalso participated in a meeting of the Boardof Thoracic Surgery in Philadelphia onFebruary 2-3, and attended meetings oithe Society for Clinical Surgery, the So­ciety of University Surgeons, and theHalsted Centennial in Baltimore, Febru­ary 6 to 9.Dr. E. Russell Alexander has beengranted the $500 Jessie Horton Koesslerfellowship by the Institute of Medicine ofChicago for work on the pathogenicity,pathogenesis, and pathology for the lab­oratory mouse of recently isolated strainsof Histoplasma capsulatum. The work willbe done in the Public Health and Pre­ventive Medicine Laboratory under the di­rection of Dr. Clayton G. Loosli.Dr. J. Garrott Allen addressed theconvention of the Association of MilitarySurgeons, which met in Chicago on Oc­tober 10, on the use of blood plasma. OnOctober 22 he spoke on "Homologousserum jaundice and its relationship tothe methods of storing pooled plasma" be­fore the meeting of the American Asso­ciation of Blood Banks in Minneapolis. InJanuary he took part in a round table con­ference on blood clotting, sponsored by theJosiah Macy, Jr., Foundation, New YorkCity. And on February 15, Dr. Allentalked on the "Use and abuse of bloodtransfusions in surgery" before the Balti­more City Medical Society.The University of Chicago had the fol­lowing representatives on the faculty ofthe Chicago Medical Society's postgradu­ate course in obstetrics and gynecology,October 22 to 26: Dr. George J. Androsdiscussed "Management of the suspiciouscervix in everyday practice," Dr. M. Ed­ward Davis "Present day indications forCesarian section," Dr. H. Close Hessel­tine "The management of infections of thevagina and pelvis," and Dr. Stephen Roth­man "Physiologic and pathologic changesin the skin and vulva during pregnancy."Dr. E. S. Guzman Barron, professorof biochemistry, was a guest speaker inMexico City at a scientific congress heldfrom September 24 to 30 commemoratingthe 400th anniversary of the founding ofthe National Independent University ofMexico.Dr. D. M. Bergenstal, '47, spoke on"Bilateral adrenalectomy for human can­cer" on February I I before the NorthSuburban Branch of the Chicago MedicalSociety.Dr. James R. Blayney has been elected vice-president of the Institute of Medi­cine and Dr. Henry T. Ricketts has beenelected chairman of its board of governors.Dr. Matthew Block discussed "Bonemarrow in the diagnosis and treatmentof polycythemia vera" before the ChicagoPathological Society on January 14.Dr. Frances Brennecke and Dr. D. M.Bergenstal presented a paper, "A prelimi­nary report on the use of certain 8-amino·­quinoline compounds in rheumatoid arthri­tis," on January 30 before the ChicagoRheumatism Society.Dr. Henry W. Brosin, formerly a mem­ber of the University of Chicago facultyand now director of Western PsychiatricInstitute and Clinic and chairman of theDepartment of Psychiatry of the Univer­sity of Pittsburgh School of Medicine,spoke on "Significant advances in psy­chiatry" on October 24 before the ChicagoMedical School.Dr. William Burrows flew to NewDelhi, India, in November to attend ameeting of the World Health Organiza­tion Expert Committee on Cholera, anda meeting of the Cholera Advisory Com­mittee of the Indian Council of MedicalResearch.Drs. Paul R. Cannon and StephenRothman were among the participants inthe postgraduate courses of the AmericanAcademy of Allergy at the Hotel Shermanin Chicago, February IS to 17:Dr. A. J. Carlson, Frank P. Hixon Dis­tinguished Service Professor of PhysiologyEmeritus, gave the fifteenth Christian Fen­ger Lecture of the Institute of Medicineof Chicago and the Chicago PathologicalSociety on November 23 at the PalmerHouse. His subject was "Some medico­social problems created by modern medi­cine." Dr. Carlson was also among theone hundred persons who received Cen­tennial Awards for the Northwest Terri­tory from Northwestern University at itsCentennial Convocation.The Illinois Society for Medical Re­search, an affiliate of the National Societyfor Medical Research, this year has electedDr. Carlson president, Dr. N. R. Brewer,secretary, and Dr. Carl C. Pfeiffer, treas­urer.Drs. Kenneth Cochrane, MohamedDahl, and Kenneth DuBois presentedpapers at a meeting of the American So­ciety for Pharmacology and ExperimentalTherapeutics at the University of Ne­braska Medical School in Omaha, Octo­ber IS to 17·Dr. Lowell T. Coggeshall flew to Li­beria early in January in a chartered planeto attend the dedication of the LiberianI nstitute of the American Foundation forTropical Medicine. He also attended theinauguration of W. S. Tubman, the newpresident of Liberia.Dr. Gail Dack discussed "Food poison­ing" before the annual meeting of theAssociation of Military Surgeons in Chi­cago on October 9.Dr. M. Edward Davis discussed "Mod­ern management of the placental stage and postpartum hemorrhage" beforepostgraduate assembly of the NashTennessee, Academy of Medicine, Oct3 to 5. Dr. Keith S. Grimson alsoticipated in this assembly and spokr"Use of sympatholytic and parasyrtholytic drugs."Dr. W. J. Dieckmann was guest sper at the Salt Lake City meeting ofUtah State Medical Association, Sepber 12 to 14.At the Chicago Medical Society's eiannual clinical conference on March7, Dr. Albert Dorfman spoke on "Rmatic fever," Dr. Theodore Rasmuon "Fractures of the skull," andHenry T. Ricketts on "Problems inbetes." Dr. Lowell T. Coggeshallchairman of the conference.Dr. Robert Ebert has been askecserve on the Board of Directors ofEdward Sanatorium in Naperville."Biology of ethics" was discussedDr. Ralph W. Gerard on Novembein a series of Lectures to the Laity,sen ted by the New York Academy of IIicine at academy headquarters.Dr. Berigt Hamilton has been trIerred from his position of clinical direof Staten Island Marine Hospital, IYork, to that of director of Hospitalvey and Construction Program, Regier(Ohio, Michigan, and Kentucky) in CIland. He reports his present score in gr:children: 10.Dr. Nellie X. Hawkinson became eritus professor of nursing education on !tember 30. She will remain on the facfor the current year.Dr. H. Close Hesseltine spoke bethe Wisconsin State Medical SocietyOctober 3, and the Mississippi Valley :tv.ical Society meeting in Peoria on Septber 20. On October 28 at the joint sctific meeting in Chicago of the CenStates and the Chicago Societies of Inctrial Medicine and Surgery, Dr. Hestine discussed "The menopause in the,ployee" and Dr. George V. LeRoy spon "Industrial application of radioactiviDr. Charles B. Huggins presenteepaper on "Influence of bilateral ad renatomy, adrenocorticotrophin, and cortisacetate on certain human tumors" belthe National Academy of Sciences meetat Yale University on November 5 to :Dr. Eleanor M. Humphreys presentepaper on "The thymus and thymic turrin myasthenia gravis" at the Februarymeeting of the Chicago Pathologicalciety.Dr. Henry R. Jacobs is president ofNorth Suburban Branch of the ChicMedical Society. .Dr. Leon O. Jacobson lectured belthe U.S.P.H.S. Institutes of HealthBethesda, Maryland, on "Studies on Itors influencing recovery from radiationjury" in January.Dr. Norman Johnson spoke on "AIthesia for urgent intra-abdominal surein patients with cardiovascular disease"MEDICAL ALUMNI BULLETIN 13ore the January 22 meeting of the Chi­ago Society of Anesthesiologists.Dr. Joseph Kirsner participated in thelorth Texas-Oklahoma Annual Medical'onference held in Wichita Falls, Texas,I September.Dr. Nathaniel Kleitman spent the sum­ier in Norway in order to study the prob­!m of sleep and wakefulness during con­inuous daylight.From October 22 to November 3 Dr.Jayton G. Loosli participated in the con­erence of professors of preventive medicineI San Francisco and also presented a papern histoplasmosis before the meeting of the.merican Public Health Association. EarlyI December he represented the Committeen Air-Borne Infections at a conference atie Streptococcal Disease Laboratory, War­en Air Force Base in Wyoming. In Feb­uary he participated in panel discussionst the Common Cold Conference held atie Palmer House. In March he will dis­uss the environmental factors in the pre­ention of communicable diseases on aanel on shipboard and submarine medi­ine sponsored by the Committee on Medi­II Sciences, Research and Developmentoard of the U.S. Department of Defense.Dr. C. Phillip Miller has been ap-ointed to the Committee on Internationalxchange of Persons of the Conferenceloard of Associated Research Councils, theody which administers the Fulbright fel­iwship program.Dr. F. J. Mullin, Dean of the ChicagoIedical School, has been appointed chair­Ian of the newly created National Inter­ssociation Committee on Internships. Hisommittee will put into operation a planuggested by Dean Mullin for arrangingiternship appointments by matching pref­renee of students with preference of hos­itals.Dr. Frank J. Orland participated in aelephone symposium on "Dental caries" onlovember 12. The broadcast from the Uni­ersity of Illinois reached audiences in 173ities in North America.Dr. Joseph Parks, instructor in radi­logy, left on February I to join thelannick Clinic in Pocatello, Idaho.Dr. Edith Potter has received the ElizalIackwell Citation, an annual award to a/oman who has achieved a distinguishedosition in the field of medicine. Dr. Pottereceived the award for "her outstandingontributions in the field of pathology."ler new book, Pathology of the Fetus andhe New-born has just been published by[ear Book Publishers, Chicago.Dr. Stephen Rothman conducted a syrn­osium on the physiology and chemistry ofhe skin at the meeting of the Americanicademy of Dermatology and Syphilologyt the Palmer House, December 8 to 13.Ie took part in panel discussions on theharmaceutical therapeutic sections and onlCTH, cortisone, and related steroids inlermatology as well. Dr. Delbert Bergen­tal participated also in the panel onICTH.Dr. Robert V. Slattery is associatedvith Dr. James B. Graeser in Oakland,:alifornia, practicing internal medicine.Dr. Robert C. Smitter is associated withhe Magan Clinic in Covina, California'near Los Angeles) as obstetrician-gyne­ologist.Dr. Rose Engel Sternheimer has re- RESIDENT NEWSMichinosuke Amano, resident in anes­thesiology, was presented with a certificateof honorary membership in the SociedadCubana de Anestesiologia by Edward R.Woodward at the surgical residents staffmeeting in Billings Hospital on Tuesday,November 6. Dr. Amano thus becomes thetenth person to be so honored, the othersincluding two physicians from the UnitedStates, and one each from Brazil, Germany,France, Italy, Switzerland, England, andCanada. Dr. Amano is the first Japanesephysician to receive post-graduate trainingin anesthesiology.James L. Baldwin has opened an officefor the practice of otolaryngology in Dallas,Texas.Clarence Bernstein is in private practicein Orlando, Florida.Harold J. Brumm is chief of the De­partment of Medicine at the Thompson­Brumm-Knepper Clinic in St. Joseph, Mis­souri. He is married and has four children.Among former University of Chicagoresidents or medical students attending theAmerican Academy of Orthopedic Surgeryin Chicago, January 28 to 31, were Craw­ford Campell of Albany, New York, PaulHarmon of Hollywood, Paul E. McMas­ter of Beverly Hills, California, and For­rest Swisher of Washington, D.C. Sam W.Banks was chairman of the committee incharge of arrangements and more than2,500 specialists attended the conference.T. H. Clarke, of Park Ridge, Illinois,is now assistant professor of surgery atNorthwestern.Ward D. Coffman is assistant residentgynecologist and resident pathologist onthe gynecological service at the Johns Hop­kins Hospital. His wife, the former Pa­tricia Sayer (University of Wisconsin, B.S.,1949), formerly on the nursing staff atLying-in, is now on the nursing staff ofthe Women's Clinic at the Hopkins Hos­pital.Capt. Hugh S. Collett is chief of theDepartment of Surgery at Kindley AirForce Base in Bermuda. He was called toactive duty last July. For the year priorto that time he was resident in surgery atSt. Joseph's Hospital in San Francisco.Gus Eckhardt is doing surgery in asmall group in San Angelo, Texas. He stillhopes to get back to Chicago for theChristmas party some year, but in themeantime he has recently had opportunityto check up on Billings news with HarryOberhelman, '47, at present in the medi- cal corps at Goodfellow Air Force Base,when he presented some of Dr. Dragstedt'swork at a county society meeting.Joseph P. Evans, head of the sectionon neurosurgery at the University of Cin­cinnati College of Medicine, spoke on"Head injuries" before the North SuburbanBranch of the Chicago Medical Society onDecember 10.Joseph Gosman is in the private prac­tice oi orthopedic surgery in Toledo, Ohio.Robert Green is in private practice ofneurosurgery in Essex County, New Jersey,covering hospitals in Newark, Orange, andSummit, following the completion of hisresidency last spring at Johns Hopkinswith Dr. A. E. Walker.Courtney N. Hamlin is one of elevencertified specialists in Rockford, Illinois,who have organized the Medical Clinic oiRockford. They now have fourteen doctorson their staff and will finally have twenty.They are finding it a fine way to practicemedicine.John E. Harvey left his practice in Vic­toria, B.C., last July to join the staff of theUniversity of British Columbia, Vancouver,where he is associate professor of neuro­logical research. This is a new departmentin a new medical school; the first class willgraduate in 1954.George B. McMurtrey is practicing gen­eral surgery in Omaha, Nebraska.Moore Moore, Jr., has been practicingorthopedic surgery in Memphis since thewar. He spent five and a half years withthe Navy during the war.Bernard Mortimer is chairman of thedepartment of obstetrics at Silver CrossHospital and attending obstetrician at St.Joseph's Hospital in Joliet, Illinois. He hasbeen certified by the American Board andis a fellow of the American College of Sur­geons. His wife, the former Edna Zeltner,M.D., from Woman's Medical College, iscertified by the American Board of Pedi­atrics and is a fellow in the American Acad­emy of Pediatrics.Lt. B. E. Robinson, USAF (MC), is inthe 3700th Medical Group, 3700 AFIW,Lackland AFB, Texas, where he is enjoyingthe warm winter weather of southern Texas.Thomas S. Saunders, of Portland, Ore­gon, wishes to express his gratitude to themembers of the hospital staff for the excel­lent care given his wife during her illnessin December of 1950.Joe Scull, formerly of the pediatric resi-[C oniinued on page 14]turned to The Clinics to a part-time ap­pointment as assistant professor in anes­thesiology.Dr. Richard B. Stoughton, instructor indermatology, reported to the Army Chemi­cal Section, Edgewood, Maryland, on Feb­ruary I.Dr. Robert Tschirgi, '50, assistant pro­fessor of physiology, participated in a pro­gram on "Bronchial asthma" at a meetingof the Chicago Psychosomatic Forum onNovember 21. Dr. George Crichton Wells has ac­cepted an appointment as assistant pro­fessor in dermatology at The Clinics.Dr. Paul Weiss, professor of zoology,has been made a foreign member of theSwedish Royal Academy of Sciences. Alsohe was recently made chairman of the Di­vision of Biology and Agriculture of theNational Research Council.Dr. Sewall Wright, professor of zool­ogy, has been elected president of theAmerican Society of Naturalists for 1952.14 MEDICAL ALUMNI BULLETINResident News-[Continued from page I3ldency staff, has given up his private prac-'tice in Houston, Texas, after seven years,to accept a full-time appointment as assist­ant professor of pediatrics at Stanford Uni­versity School of Medicine. Last year Joeworked with Dr. Hale Shirley in the ChildGuidance Clinic as pediatric fellow in childpsychiatry and this year will become direc­tor of a new Well Child Care Program andcoordinator for the Children's Out PatientClinic with the Guidance Clinic. In addi­tion, he will serve as pediatric consultantto the California State Health Departmentfor the northern California area, The Scullshave a s-year-old daughter, Sorrell, and a3-year-old son, Jay, and are now livingin Sausalito, just across the Golden GateBridge from San Francisco. Dr. Scull writesthat there are quite a few Chicago alumniin the northern California area: CharlieBranthaver, '4.J, in Sacramento, LouiseBurr on the Permante staff in Oakland,Hawley Parmelee, '43, practicing in SantaMonica, and Grace Goebel, '43, in MillValley. Peter Beal, '42, is dermatologist onthe visiting staff at Stanford. He speaksvery warmly of the pleasure it gave him andhis colleagues to have Dr. Howell Wrightat Stanford last June as guest leader of thepost-graduate workshop in child psychiatryand mental health.Robert B. Woodhull, of Minot, NorthDakota, has been elected president of theNorth Dakota Society of Obstetrics andGynecology.Scientific Section+-[Continued from page II 1with the acute phase of chronic leukemia.The tissues of the patients prior to treat­ment consisted of so dense a structure­less mass of leukemic cells that theorgan was not easily recognizable. Dur­ing remission fat appeared in the mar­row. Erythroblasts, granulocytes andtheir precursors, and megakaryocyteswere found in approximately normalnumber and degree of maturation. How­ever, small islands of stem cells were al­most invariably demonstrable at the sametime.Similarly, a normal architecture, in­cluding recognizable white pulp andcords and sinuses in the red pulp, wasdemonstrable in the spleens of patientsundergoing a remission. Islands of stemcells were always seen in the white pulpin even the most complete remission.Usually the tissues of patients not de­veloping a remission, even if they hadbeen treated successfully previously, didnot show any change following treat­ment.The Cortisone Treatment ofStrictures of the UrologicalTractBy ROGER BAKER, M.D.UrologyStricture formation is often a majorurological disease or complication. These strictures occur in the urethra or theureter. The urethra is a passive tubethrough which urine courses and the kid­ney is buffered from the urethra by theinterposed bladder with its ureterovesi­cal valves. Urethral strictures usuallycarry no serious prognosis but they areoften of great concern to the patientbecause of the symptoms produced, theever-present possibility of cystitis, andthe discomfort and economic demandsassociated with indefinitely continuedtreatment. The ureter, on the contrary,is an active organ of urinary excretion.In consequence, ureteral strictures, irre­spective of location or degree, often re­sult in serious renal disease.Hydro-ureter and hydronephrosis fol­lowing uretero-intestinal implantationare, for the most part, attributable toscar tissue deposition about the uretersecondary to the normal healing process.Hinman and Weyrauch have demon­strated experimentally this periureteralconcentric fibrosis of the ureter as ittraverses the bowel wall. Other commonexamples of ureteral strictures are thoseresulting from anastomosis of ureter toureter or ureter to bladder. Urethralscarring may be observed at the bladderneck following certain cases of trans­urethral electro resection of median baror prostatic hypertrophy. These samesurgical procedures not infrequentlyproduce scarring of the pendulous ure­thra. Urethral strictures from gonorrhealinfection are observed, but not so oftenas formerly. Finally, the most carefullyperformed plastic operation for hypo­spadias is often complicated by stricturewhich requires urethral dilatation formany years.The present communication reportsclinical and experimental observationson the use of cortisone to reduce the for­mation of scar tissue in urologicalwounds.Ragins and co-workers and also Spainet al. have demonstrated inhibition bycortisone of granulation tissue formationin experimentally induced wounds. Sub­sequent to the initiation of the presentinvestigation, Rosenberg and his grouphave shown that cortisone greatly di­minishes the tendency to scar tissue con­tracture in experimental esophageal in­juries. Stinchfield applied cortisone suc­cessfully in preventing excessive fibroustissue formation after experimental ar­throplastic procedures. Physiologically,the mechanism of action of cortisone isprobably due in part to a local inhibi­tion of fibroblasts and inhibition of thesynthesis of certain mucopolysaccharidesby connective tissue cells. Wounds ex­hibit high capacity for the incorporationof inorganic sulfate into the chondroitinsulfate of granulation tissue. Layton hasfound that cortisone retards synthesis ofthis chondroitin sulfate moiety of theconnective tissue ground substance. TABLE ITypes of Stricture StudiedUrethral StricturesFollowing repair of hypospadias'(I not improved)Post-gonorrheal infectionFollowing excision of urethral calculusPost-transurethral surgery(I not improved) , .Contracture of Bladder NeckFollowing resection of congenital contracture .Post-transurethral prostatectomy .Post-transurethral resection bladdepapillomata , .Ureterovesical stricturel_; retero-intestinal implantationUreteropelvic pyeloplastyTOTAL,PROCEDURE AND RESULTSTwenty-eight patients with vartypes of ureteral and urethral strictwere studied (Table I). Each patwas given cortisone, I So mg. daily,two days prior to surgery. At SUfithe stricture was excised, incised, ortured. All urethral operations ,s.plinted by a catheter for two to tlweeks. Cortisone, 100 mg. daily,administered for three weeks postoatively. All patients have been folloa minimum of six months after trment. Twenty-six of the original tweeight patients have had excellentsuits. Prior to treatment each of tlpatients required dilatation of the SIture once every two to three weNone of the twenty-six have requdilatation since cortisone therapy. rpatients have not 'been improved.explanation for these failures isknown.From the experimental standpithree dogs, with unprepared bowel, Ihad ureterosigmoidostomy and t.have had re-anastornosis of ureter tobladder. These dogs were given cortis50 'mg. daily, for three weeks �operatively. Microscopic sections ofuretero-intestinal and ureterove:anastomoses reveal only minimal fibtissue reaction, whereas in the cordogs there is dense peri ureteral scarand stricture. The dogs treated 'cortisone had normal caliber uretersno hydronephrosis. The untreated Itrol dogs all had hydroureter and hynephrosis.CONCLUSIONSCortisone apparently has a definitein the prevention or treatment of s:tures of the urinary tract. The definidosage and duration of therapy ,cortisone are not known and can no'specified until further clinical investtion of a larger series of patients is mMEDICAL ALUMNI BULLETIN ISAlumni News-[ Continued from page 7lMaj. C. J. Ruth returned from Korealate last fall. He is an orthopedic surgeryresident at Fitzsimons Army Hospital inDenver and hopes to be there for twoyears. He would be glad to hear from anyof his friends who are in or near Denver.Christmas greetings arrived from theOlaf Skinsnes' family in Hong Kong. Olaf� working in the Department of Patholo­!y, University of Hong Kong, and is par­ticularly concerned with the study of lep­rosy. The American Leprosy Missions sup­ports his research and he has severalprojects under way and has accumulatedI good deal of teaching and study ma­:erial. He has some 320 leprosy patientsmder his care and a leprosarium is being:onstructed on an island some seven milesnitside harbor limits. He estimates thathere are lOOO leprosy patients in HongCongoThomas Tourlentes has completed hisesidency training in psychiatry under Dr.lules Masserman at the Veterans Adminis­ration Hospital at Downey, Illinois, ands now associated in a staff capacity asieuropsychiatrist with the Mental Hygiene:Iinic of the Veterans Administration Re­jonal office in Chicago.'48. Dick Blaisdell is still in the Armyvith little hope of getting back to teach­ng and research very soon.Charles J. Buhrow is senior assistanturgeon, U.S.P.H.S., in the Division of)ccupational Health, Cincinnati.Harold G. Carstensen is at present at­ending the Medical Field Service Schoolt Ft. Sam Houston in order to learn howo be an administrator in the Army Medi­al Service. He says it looks as if Ob-Gyn, a long way off for him. Fortunatelyis family is with him. On his way tot. Sam Houston, Carstensen visited Dr.[epner and his family in Galveston andnmd the Hepners apparently well pleased'ith the setup at the Medical Center.1st Lt. Philip Glotzer is with the 57thield Hospital in Europe. He says his dutynot much to his liking, but is muchstter than most of the others in Europe.is address is 01874425, APO 227, c/oistmaster, New York.1st Lt. Wm. S. Horowitz spent a shortne at the General Hospital in Cincin­ui before he entered the Air Force. Hepracticing psychiatry of sorts at Wright­uterson Air Force Base in Dayton. Hees Bob Channock occasionally who isnking for Dr. Sabin in Cincinnati.Ernest R. Jaffe has been in the Airnee at Carrwell Air Force Base for aar and is anxiously waiting for the timelen he can get out.Warren Rasmussen is serving as a.dical missionary with the Sudan Inte­,r Mission stationed at Saddu, Ethiopia.Robert C. Robertson is at present a:ond year resident in psychiatry at IIIi­is Neuropsychiatric Institute.Allan D. Rosenblatt has opened anice in New York City for the practicepsychiatry. He is in the midst of his«hoanalytic training at Columbia Psy->analytic Clinic for Training and Re­rch. He is the father of a wonderfulir-old girl with another on the way. Paul Russell is in the Air Force withthe 3605th Medical Group, Ellington Field,Houston, Texas.'49. Charles R. Bacon is continuing hisresidency in surgery at the Henry FordHospital in Detroit after two years inCalifornia.H. W. Bardenwerper is medical officerin charge of the Armed Forces ExaminingStation in Milwaukee. They examine aboutfour hundred men daily for induction aswell as volunteers for all four armed serv­ices-a busy place!John E. Gill and his family are nowliving in their new home in Alameda, Cali­fornia. He has two daughters, 21 and 9months. He is Flight Surgeon for VR2,the Navy squadron flying the Mars am­phibians between here and Honolulu. Theyare well pleased with John's duty andthey love their home.Capt. William K. Graves is servingin the Air Force at Clark Field in thePhilippines, and expects to return to theU.S. next October. He is doing the ob­stetrics and gynecology for this stationhospital.Lt. (j.g.) William E. Hummel is withthe Navy on the transport USNS GeneralC. G. Morton.Clifford Leigh Peasley is opening hisown office in Portland, Oregon.James M. Smith is home after his sec­ond tour of sea duty in Korean watersaboard the U.S.S. Toledo. It has been amost interesting experience-they main­tained a five-day-a-week schedule of sur­gery ranging from shrapnel wounds totonsillectomies and excision of pigmentednevi. Betsy and Jim and their new son,Steve, are now in San Diego where he hasbeen assigned duty at the amphibian base.l st Lt. William H. Wainwright has afine job as flight surgeon on a large base35 miles from Tokyo. He is also doing alot of work in psychiatry, and learninga great deal. He says Japan is a fasci­nating country and offers much hospitalityduring leisure hours. However, their healthstandards do not measure up to their inge­nuity, industriousness, or graciousness.'50. Bernard Barash is a first-year resi­dent at the 'University of Pittsburgh whereDr. Brosin is director, Bill Earley, '42,is associate professor, and Ralph Coppolais also a first-year resident. They are allquite happy there. The Barash family nowincludes three boys.Donald J. Barry left the Temple CityMedical Group at the end of last summerand opened his offices in Arcadia, Cali­fornia.J. A. Fil6s-Dias completed one year ofinternship in the Santo Tomas Hospitalin Panama City last May and has sincebeen in the Chiriqui Land Company's hos­pital in Almirate, province of Bocas delToro. He expects to be there until 1953,when he hopes to return to the States fortraining in internal medicine.Henry Gelfand writes from Liberiawhere he is senior assistant surgeon forthe U.S.P.H.S. at the Liberian Instituteof Tropical Medicine. His title is MedicalEntomologist and his main activity is thestudy of malaria vectors. The country isbeautiful and the climate superb. despitean annual rainfall of 170 inches. He andhis family (his wife and two sons) have afine house and an active social life. They look forward to a pleasant three or fouryears there.Thomas B. Hill has entered generalpractice in Lowell, Michigan, a town of2000 near Grand Rapids.Attallah Kappas is A.C.S., C.O.G. re­search fellow in steroid metabolism at theSloan-Kettering Institute for Cancer Re­search in New York and special fellow inmedicine at Memorial Hospital. He enjoysthe work enormously and finds himselftempted to return to Chicago for a Ph.D.in biochemistry.'51. Wallace B. Dorain writes that heis very happily situated at the HuntingtonMemorial Hospital in Pasadena where hewill be interning until October, 1952.Edith Goldfarb has a 3-year appoint­ment with the Associated Psychiatric Fac­ulties of Chicago as a rotating resident­one year each at Billings, Michael Reese,and Illinois Neuropsychiatric Institute­beginning July I, 1952.Joseph L. Ousley will begin a residencyin internal medicine at Wisconsin GeneralHospital next July. He is interning therenow.George Spikes has a residency in in­ternal medicine at Veterans Administra­tion Hospital in Houston for next year.He sees Ray Hepner, '44, who is in pedi­atrics at John Sealy Hospital.Dr. Phemister-[C ontinued from page 2]dents. Others have carried his influence inroles of high responsibility to many ofthe institutions of medical education ofthe country.The achievements of Dallas Phemisterbrought him every recognition that themedical world confers. Thus, among hismany other positions of distinction, hewas President of the American Collegeof Surgeons, President of the AmericanSurgical Association, President of the So­ciety of Clinical Surgery, and last Sep­tember the Vice-President of the ParisCongress of the International Surgical So­ciety. Nine foreign societies have madehim a fellow or conferred their medalsupon him. He was honored internationallynot only because he was a great surgeonand investigator, but also because he rep­resented the ideal physician.He was so modest and unself-seeking aman that praise and honors were an em­barrassment to him. He could not com­fortably accept praise, and unlike mostmen, he sought to avoid rather than toencourage it. He shrank from publicityof any kind. The only pride of accom­plishment he ever exhibited was that fol­lowing the success of a pupil or an asso­ciate. His satisfaction came in theirgrowth and progress. He never neglecteda chance to encourage them or assist intheir advancement. Under him the De­partment of Surgery has achieved a fineesprit; his was not a one-man show, buta group in which everyone worked hardtoward the common end of medical ad-vance.r C ontinued on bare 16116 MEDICAL ALUMNI BULLETINNearly five years ago, Dr. Phemisterreached the University retiring age of 65his skill and his zest as keen as they had 0ever been. The University fortunatelywas able to persuade him to continue,though he was emeritus, his full-time ap­pointment, in which he maintained hisregular schedule with but one exception.His scrupulous concern for others led himto make the rule that he would not attendany administrative conferences, lest hispresence appear to be an interferencewith the authority of his successor.DR. L. DEJARDIN, secretary general ofLa Societe Internationale de Chirurgie andDR. PHEMISTER, vice-president of the so­ciety, in Paris at the 14th Congress in Sep­tember, 1951.To those of us who knew and loved himthese platitudes seem pathetically inade­quate. His true character can best be ex­pressed in his own words. I have a copyof probably his last letter addressed to afriend who, after being hospitalized, wrotein complimentary terms about him, hisstaff, and the school. In the reply hestated, "I am deeply touched but in real­ity what I have done is not nearly as sig­nificant as might appear on the surfacesince the Department has been made bya number of men who have given theirbest efforts along various lines and overlong periods of time. About all the chair­man of a department does is to do thebest he can as teacher, clinician and inves­tigator in the hope that it may be anexample that inspires others to make alike endeavor, and to see to it that themen in the department are provided withgood facilities to work themselves." Thatwas Dr. Phemister, who was always mo­tivated by altruism, self-effacement, andhumility. He never had to think what wasthe right thing to do-he knew it.In the future we cannot do what hewould have done and we will miss himsorely, but what we are about to do wewill do better because of him.LOWELL T. COGGESHALL 25th Anniversary ofThe ClinicsIn October, 1952, The Clinics,Albert Merritt Billings Hospital,and the School of Medicine willbe twenty-five years old.Dr. Paul C. Hodges is devotinga great deal of his abundant energyand imagination to plans for a fit­ting celebration, tentatively sched-uled for October 3 and 4. .Included in the program are asymposium on the history of thedevelopment of The Clinics, a sci-:entific session, and a banquet. Inaddition, the first Phemister Lec­tures will be given on the eve ofthe celebration, Thursday, Octo­ber 2 (see p. 4).Dr. Hodges has the help of sev­eral committees-alumni activities(Clayton G. Loosli, chairman),history (Franklin C. McLean,chairman), degrees and awards(Lester R. Dragstedt, chairman),and nurses' activities (Miss Doro­thy Morgan, chairman). All thesecommittees are working togetherto plan a stimulating program forall friends of The Clinics and themedical school. The detailed pro­gram will be announced in thespring issue of the BULLETIN.Corridor CommentThe medical students' lounge and ournew office are nearing completion. Allthe alterations have been made, and weshall move in as soon as the rooms arepainted and furnished. We hope that allof y?u will pay us a visit at the springreunion.Whe� you come to Chicago in June,you will find many changes in TheClinics. The new Argonne Hospital onEllis Avenue just north of Goldblatt (tobe dedicated at the twenty-fifth anni­versary in October) is almost finished.The Gilman Smith and the West Wingon Drexel Boulevard, north of BobsRoberts, are rapidly taking form-thenoise and the dust are terrific, but theprospect is magnificent.We were cheered in the middle of ourbleak winter by a gift from BernardKane, ']2, of Crescent City, Florida. Hesent bushels of ripe tangerines, pickedfrom his own backyard-some for theinterns' quarters and some for "thosewho toil for the Association." Theytasted wonderful to all of us.As you see, we have expanded theBULLETIN in order to present abstractsof some of the papers covering researchat The Clinics. We are very grateful tothe authors, and wish to urge alumni atother universities to submit digests oftheir publications for the BULLETIN. Ifthis feature proves of interest, it will becontinued in future issues. REUNION IN 1952In the second week of June the Arnecan Medical Association will meetChicago, and many of you will be hifor the first time in many years. We ,planning our banquet and annual meing for the middle of that week=-Wrnesday, June II-SO that everyone wis here for the A.M.A. may attend. Asome time during that week the seni.will give reports on their research at jannual Senior Scientific Session.The banquet will be at the Del PraHotel, and George V. LeRoy (Associ:Dean of the Division), who is in chaiof arrangements, is making plans for fhundre� or more. As in the past, 1graduating seniors and their wives vbe our guests.You are urged to make your reset­tions as soon as possible. We especiawish to include your wives or husbanThis is a reunion you will not wantmiss.DUES AND GIFTSIt is gratifying to report that 50 rcent of our graduates, faculty and f­mer interns and residents have' paid dufor 1951-52 or have become life-me­bers and that ninety-three donors hs �contributed gifts totaling over $1,100lof March 1, 1952. This evidence of yr:loyalty and support is what we need Imaintain a flourishing alumni organi .tion.Alumni who have not yet mailed do;and gifts may send them with the for;accompanying this issue of the BUL'TIN. Remember, when you send YOl;,tha t the dues are kept low to ena �everyone to belong. but that, in additi ,gifts from those of you who c-an aff'!to give are necessary in order to rn :our operating expenses and to particip :actively in helping to advance the int -ests of the medical school.B'ULLETINof the Alumni AssociationThe University of ChicagoWILLIAM LESTER, JR., EditorHUBERTA LIVINGSTONE, Associate EditorSCHOOL OF MEDICINWINTER 1952 No.,VOL. 8Memb.,5 of tite Editorial Board:CLA YTON G. LOOSLIROBERT H. EBERTJESSIE BURNS MACLEAN, SecretaryPrice of yearly subscription $2.00