ilume 5 SPRING 1949 Number 3ARGONNE CANCER RESEARCH HOSPITALThe initial plans and estimates for the Argonne Cancer Researchl!I ,pilal have met with the approval of the authorities of the AtomicIlrgy Commission. The estimates for the cost of construction totallIi'roxima.tely $3,200,000. Plans call for the erection of this build-� on the west side of Ellis A venue extending immediately north ofGoldblatt Memorial Cancer Hospital wing of the Clinics. It isierstood that the cost of operation will be borne by the Atomic11 lrgy Commission through the Argonne National Laboratories.J The hospital will be operated by the University of Chicago in con­tum. with the Argonne National Laboratories and the Atomic� lrgy Commission. There are twenty-nine co-operating universi­'1 associated with the Argonne National Laboratories, seventeen� �hich have medical schools and are interested in research studies,:1 Jiving the use of radioactive isotopes.The primary objectives of the research that will be conducted in'd· new hospital pertain to the use of radioactive isotopes in the(II gnosis and treatment of cancer. It is not anticipated, however,'J! all the research work will be restricted to this particular area. The main building of the unit will consist of subbasement,basement, and six floors. Two of these floors will be devoted to thestudy and care of patients. The remaining floors will be devotedto laboratories, shops, and animal quarters. The subbasement u-illconnect with an underground structure that trill house a 40 MEVbetatron, a 2,000,000-volt Vandergraf unit, and a room in u'hid,patients can be exposed to the direct radiation of radioactive ma­terial.All clinical service and research studies involving the care of pa­tients will be under the direct control of the members of the clinicalfaculty of the University of Chicago. It is anticipated that researchworkers from other institutions will be accommodated. The programof investigative studies will be under the control of a medical ad­visory committee to the Argonne National Laboratories of which theDean of the Division of Biological Sciences will be an importantmember. Itis anticipated that direct administrative control of theinstitution will be lodged in the Dean of the Division of BiologicalSciences.2 MEDICAL ALUMNI BULLETINThe Student HealthService and Its ResearchProgramDuring the last three years the Stu­dent Health Service has discarded its for­mer role of distant relative to The Clinicsand has taken on a share of medical train­ing and investigation. In 1946 Dr. Clay­ton G. Loosli considered the field ofhealth service productive for develop­ment and undertook to increase the fa­cilities in order to provide a more com­plete type of curative medical practiceand to emphasize preventive medical pro­cedures.As one means of accomplishing this re­orientation, the nursing and clerical staffswere increased, thereby enabling the doc­tors to utilize their own time to best ad­vantage and also making available tothem assistance in compiling data fortheir research projects. One of the out­standing results of this reorganizationhas been that the new program attractscapable young physicians interested in in­vestigative medicine, many of whom arepreparing for certification board exami­nations. Most of the physicians on thestaff are in different stages of training,varying from residency grade up, on theway to becoming internists. Originallythey are given appointments as assistantsin the Department of Medicine and aftertheir first few weeks of orientation, theyspend one half of their time in a programof research to complement the time spentin the Student Health Clinic.In addition, clinical training is provid­ed in the Student Health Clinic for resi­dents in the specialized divisions of TheClinics. A rotation of service of residentshas been established in dermatology, ear,nose, and throat, obstetrics and gynecol­ogy, and, to supplement the work of theHealth Service psychiatrists, in psychia­try. Consultation services are provided byappropriate senior staff physicians when­ever indicated. This co-operation hasproved advantageous to The Clinicstraining program and at the same time isproviding an excellent caliber of medicalpractice in the Health Service Clinic.The result of having such a team ofphysicians working with complete facili­ties has been to uncover morbidity ratesamong students considerably in excess, inmany instances, of that previously sup­posed to exist in a student population.The emphasis on preventive medical pro­cedures has been most prominently de­veloped in the fields of influenza and tu­berculosis and has provided material foran interesting series of reports. The 1947pandemic of influenza was analyzed lo­cally as it affected vaccinated and non­vaccinated students. The inefficacy of thevaccine was clearly demonstrated, andthe previously unknown specific virusstrain responsible for this epidemic wasdiscovered. Tuberculosis and its simulators, histo­plasmosis and coccidioidomycosis, are be­ing studied in the tuberculosis controlprogram under the direction of Dr.Beadenkopf. From the technical stand­point the most important result of thisprogram has been the detection of anaverage of one active case of tuberculosisper month. From an investigative stand­point, interesting geographic variationsin endemicity of the three diseases havebeen reported together with several otherepidemiological aspects. The nature ofthe pulmonary infiltrate and the symp­toms which accompany the developmentof sensitivity to tuberculin, histoplasmin,and coccidioidin are being investigated.Grants have been received from the U.S.Public Health Service to aid in theseprojects. The studies on influenza haverecently received recognition from theWorld Health Organization InfluenzaStudy Program which has designated theClinic and laboratory as an influenza de­tecting station.The investigative programs of othermembers of the Health Service staff haveled to reports on a variety of subjects.These include a series on the action ofpenicillin and its impurities against bac­terial endotoxins; observations on thepulmonary edema produced in animals byANTU poisoning; and a study of penta­quine treatment of recurrent malariaamong student veterans.Programs of investigation are underway on certain infectious diseases: theprotection afforded by penicillin and itsimpurities against experimental syphilis;the mechanism of action of bacterial en­dotoxin as demonstrated by radioactivetracer atoms. In psychiatry. an investiga­tive study of the significance of color incertain mental states has been undertakenin addition to periodic analyses of accu­mulated clinical data.In this manner a beginning has beenmade in developing the potentialities ofthe Student Health Service with particu­lar regard to fuller integration of its ac­tivities with those of The Clinics. Thedevelopment of these training and in­vestigative programs has resulted in im­provement in the quality of medical careprovided. A health service organizationhaving among its primary objectives thehealth of the student population and thedetection of disease in the apparentlyhealthy student can, in addition to pro­viding the best possible medical care forthe sick student, make important con­tributions to the science of preventivemedicine. The interest in recent years indiscovering and exploiting more sensitivediagnostic procedures for the detection ofpotentially disabling disease prior to theonset of symptoms has made possible theestablishment of a health service organi­zation which can act as a health sentinel.The immunization or shot-in-the-armbranch of preventive medicine is beinggiven a close race by that concerned withthe earlier detection of disease. The establishment of a section on pre­ventive medicine under Dr. Loosli (seeWinter Issue, 1949) is going to give addi­tional impetus to investigative work inpreventive medicine techniques in theStudent Health Service. Training andteaching in the practical application ofthese procedures will constitute an inte­gral part of the program of the MedicalSchool.William Beadenkopf BecomesDirector of Student HealthService on July 1Dr. William G. Beadenkopf, AssistantProfessor in the Department of Medicineand Assistant Director of the StudentHealth Service, will begin his new dutiesas Director of the Health Service on JulyI, 1949. Dr. Beadenkopf, a native of Bal­timore, Maryland, received his M.D. de­gree from Johns Hopkins University in1941. He then came to the University ofBEADENKOPFChicago for an internship and subse­quently a residency in medicine. In 1943he went into the Army and was assignedto the r Sth General Hospital in the FijiIslands. When the medical pace in theFijis became less urgent, the hospital wasmoved to Assam, India, and later to Bur­ma. He served on the medical and psychi­atric services and acted as co-author of areport on an epidemic in Burma of lym­phocytic meningitis which he had an op­portunity to study. Soon after comingback to the states, Dr. Beadenkopf wasenlisted by Dr. Clayton Loosli in the planfor a reorganized Student Health Service.He returned to the University in July,1946. In 1947 he was appointed AssistantDirector of the Student Health Servicealong with Dr. Walter D. Hawk. The lat­ter will continue as Assistant Director.Dr. Beadenkopf's investigative work isin epidemiological fields, principally intuberculosis, histoplasmosis, and coccid­ioidomycosis.MEDICAL ALUMNI BULLETIN 3Hoyne Retires\.fter 35 Years of TeachingDr. Archibald L. Hoyne, for manyears a favorite teacher on the faculty of.ush Medical College and the Universityf Chicago, has recently retired from ac­ve teaching. Dr. Hoyne, a native of Chi-19O, is a graduate of Lake Forest Acade­ly and Williams College. He received the.. B. degree from the latter institution in:)01. In 1902 he received the B.S. degreeHOYNEom the University and in 1904 the M.D.egree from Rush Medical College. Dr..oyne interned at St. Luke's Hospital.e has been on the attending staff of theook County Hospital since 1912, most. which time he was chief of the Con­.gious Disease Department. He first be­une associated with the Municipal Con­.gious Disease Hospital in 1917 and forany years has been its medical directorid superintendent. Dr. Hoyne was on.e faculty of Rush Medical College from113 until roar. He began teaching at the:hool of Medicine of the University ofhicago in 1932. He continued on theush faculty of the University of Illinois. professor of pediatrics until 1946.mong other professional appointments,r. Hoyne has been attending physicianthe Children's Memorial Hospital, andtending pediatrician and chairman ofe department at St. Joseph's Hospital.It was in his position as director of the.unicipal Contagious Disease Hospitalat Dr. Hoyne was able to give literallymdreds of medical students a vivid andsting impression of the various con­gious diseases. This experience hasoved invaluable to them in the prac­:e of medicine. In addition, Dr. Hoyne.5 been very active in furthering post­aduate training in the communicableseases. He has published many articlesthe pediatrics literature, principally one subject of communicable diseases. HeLS also contributed chapters on commu­cable diseases to several well-known(Cont. on page 7) Gersh Returns to U. of C.as Associate Professorof AnatomyAfter an absence of sixteen years Isi­dore Gersh returns to the Department ofAnatomy as Associate Professor. Dr.Gersh is a native of New York City, anda graduate of Cornell University, receiv­ing his B:S. degree there in 1928. Shortlythereafter he came to the University ofChicago, where he was Julius StieglitzResearch Fellow in Chemistry Applied toMedicine from 1930 to 1932. He wasawarded the Ph.D. degree in Anatomy in1932, and stayed on another year asRockefeller Research Assistant in theDepartment of Anatomy. In 1933 hewent to Johns Hopkins University as in­structor in the Department of AnatomyGERSHand continued there until 1943 save forone year spent in Stockholm as JohnSimon Guggenheim Memorial Fellow atthe Karolinska Institutet. In 1946 hejoined the Navy, serving at the NavalMedical Research Institute until 1946.Dr. Gersh was separated from the servicewith the grade of lieutenant commanderand returned to Johns Hopkins as Asso­ciate Professor of Anatomy. The sameyear he accepted an appointment as As­sociate Professor in the Department ofPathology at the University of lllinois,where he has continued until the presenttime. Dr. Gersh has made distinguishedcontributions to the improvement of thehistological techniques. He has publishedmany original cytological and histochem­ical studies of the kidney, pituitarygland, thyroid gland, adrenal gland, andthe nerve cell. During and after hisservice with the Navy he published im­portant observations on oxygen poisoningand decompression sickness. Dr. Gersh isa member of a number of learned societiesincluding Sigma Xi, the American Asso­ciation of Anatomists, the Society of Ex­perimental Pathology, and the ChicagoPathological Society. In jMtmoriamDr. Louis Bothman, 55, who was formany years a member of our ophthalmol­ogy faculty, and more recently senior at­tending ophthalmologist at St. Luke'sHospital, was stricken with a heart attackon January 19, 1948, and passed awaysoon thereafter. Dr. Bothman wasgraduated from the University of Chicagoin 1915 and received an M.D. degree atRush Medical College in 1917. He didBOTHMANgraduate work at the University of Illi­no is and the University of Vienna. Dur­ing World War I he served as navy lieu­tenant. At the time of his death Dr.Bothman was professor of ophthalmologyat the University of Ulinois and editor ofthe Eye, Ear, Nose and Throat Year Book.Surviving are his widow, Anne; hismother, Mrs. Mary Bothman, and abrother, J. J., both of Los Angeles; and asister, Mrs. Fred Kling of St. Louis.Dr. Percy J. Ross, 46, a member forseveral years of the Student Health Serv­ice of the University of Chicago, died inhis home at 38 South Spring Avenue, LaGrange, Illinois, September 28, 1948. Dr.Ross graduated from the University ofIowa College of Medicine in 1926. Afterinternships at the Montreal General Hos­pital in Canada and St. Luke's Hospital,Chicago, followed by postgraduate workin Boston, he joined the Student HealthDepartment at the University of Chicago,where his wife was an assistant hospitaldietician. Dr. Ross was a lieutenant colo­nel in World War II in the Army AirForces Medical Corps. Following thisservice, he returned to Chicago as a seniormember of the Department of Otolaryn­goloIW at St. Luke's Hospital and a mem­ber of the faculty of Northwestern Uni­versity Medical School.Dr. Ross is survived by his widow,Florence; a daughter, Betty Jean; hisparents, Mrs. and Mrs. Robert Ross ofAkron, Iowa; two brothers, Leslie andRussell; and a sister, Mrs. Janet Claeys.MEDICAL ALUMNI BULLETINSCIENTIFIC SECTIO'NSudden Vasoconstriction mCooled ExtremitiesCooling as a Stimulus toSmooth MusclesBy JOHl" F. PERKINS, JR.Department of PhysiologyWhen a man or other warm-bloodedanimal is placed in a cold environment,the skin of the extremities becomes coolowing to reflex vasoconstriction of the ar­teriovenous anastomoses, the wide vascu­lar shunts found in large numbers in theskin of the fingers and toes. Unfortu­nately in some individuals the resultingvasoconstriction may exceed the demandsof temperature regulation, leading tochronically cold hands and feet and pro­gressing sometimes until there aremarked pathological changes, as in Ray­naud's or Buerger's disease. Sympathec­tomy, probably the most successful treat­ment to date, is sometimes of only tem­porary benefit even when sensitization ofthe arteriolar smooth muscles to epineph­rine is minimized by performing a pre­ganglionic section.Some time ago, during the course ofskin-temperature studies on the peripher­al circulation, we observed a rather curi­ous action of cold upon the sympathec­tomized paw of a trained, unanesthetizeddog. Normally, when an animal is placedin a reasonably cold room at, say, ISO C.,the normally innervated paws cool rapid­ly, as a result of reflex vasoconstriction,but a sympathectomized paw tends toremain warm for prolonged periods,owing to interruption of the vasoconstric­tor nerves.We found, however, that when the airsurrounding the paw was made somewhatcolder, for example, 10° C. instead ofISO c., sudden vasoconstriction, indicatedby a rapid, continued fall in skin tempera­ture, occurred in the sympathectomizedpaw. Calculations indicated that thevasoconstriction was so marked as to re­duce the blood flow to an average of one­tenth of its original volume. Later it be­came clear, during the course of morethan twenty-five experiments performedon denervated or sympathectomized pawsof dogs and cats, that the sudden vaso­constriction took place at the momentwhen the skin had been cooled to a certain"critical" temperature, which rangedfrom 20° to 24° C. following preganglionicsympathectomy. If the room was notcold enough to cool the skin down to thecritical temperature, the extremity re­mained vasodilated and warm indefinite­ly, but if the skin was gradually cooleduntil it reached the critical temperature,sudden vasoconstriction occurred. Onsubsequent rewarming of the extremity, sudden vasodilatation occurred. It is ofinterest that a similar "critical" tempera­ture for vasoconstriction was observed atabout the same time by C. C. Ungley ofEngland in "trench" or "immersion" footof man, a condition in which degenerationof nerves, with resulting denervation ofthe foot, may occur.Since the sudden vasoconstriction oc­curred after adrenalectomy, and after to­tal denervation of the leg, it appearedlikely that it might have been due to alocally increased sensitivity of the de­nervated blood vessels to cold, with thelatter acting as a stimulus to cause con­traction of the smooth muscles of the ar­teriovenous anastomoses.As a partial test of this hypothesis, westudied the effects of cooling the normaland denervated nictitating membranes ofthe cat. As reported by previous investi­gators for other types of smooth muscles,we found that cooling alone caused con­traction of the nictitating membranes. Itwas also found, in two out of four experi­ments, that the chronically denervatednictitating membrane had become "sensi­tized" to cold, contracting more with agiven drop in temperature than the nor­mal, and also contracting in jerky, step­wise fashion when cooled.We have studied quantitatively theresponse to cooling of various smoothmuscles (with innervation intact until thestart of the experiment) including thenictitating membrane of the cat, the re­tractor penis muscle and ureter of thedog and the intestine and uterus of therat, all of which contracted when cooled.When degrees of rapid cooling (abscissae)were plotted against heights of contrac­tion, one obtained an S-shaped curve,similar to a dose response curve forepinephrine or for other drugs causingcontraction. Gradual cooling also causedcontraction, though this was less thanwith rapid cooling.Of particular interest is the fact thatthe cooling stimulus apparently causescontraction by acting on a different sys­tem than epinephrine. This was indicatedas a result of studies with the sympatho­lytic drug "Dibenamine," which reversesthe action of epinephrine, causing the lat­ter to produce relaxation in muscles inwhich it normally evokes a contraction.Cooling alone, however, caused contrac­tion both before and after Dibenamine.When cooling and epinephrine were test­ed simultaneously before Dibenamine,the resulting contraction was approxi­mately equal to the sum of their separateeffects, but after Dibenamine the twoeffects added algebraically, thus tendingto cancel out, inasmuch as epinephrinethen produced relaxation, or a "minuscontraction. " Further studies are being carried outin an attempt to determine the mode ofaction of cooling as a stimulus to smoothmuscles. These include effects of pH andpC02, muscle viscosity, action potentials,and other factors.Finally, we hope to return to the studyof responses of the peripheral circulationto' cooling, including the clinical problemof "cold feet." It appears likely that cool­ing alone, as well as vasoconstrictornerves, circulating epinephrine and otherhumoral agents, tends to cause vasocon­striction, and acts by directly stimulatingthe smooth muscles of the arterioles' of theskin to contract. Possibly some agent willbe found which will minimize this effect.HyaluronidaseBy ALBERT DORFMAN, M.D.Despite tremendous progress in thestudy of the mechanism of intraceHularenzyme reactions, relatively little atten­tion has been paid to those chemical reac­tions by which extracellular structures areformed or broken down. This has beenparticularly true of those reactions relat­ing to connective tissues. Recently therehas been a revival of interest in one as­pect of this subject relating to the poly­saccharide hyaluronic acid and the en­zyme which brings about its breakdown,hyaluronidase.The interest in this system stems fromthe classical studies of Duran-Reynals in1928 demonstrating the presence in tes­ticular extract of a heat labile substancewhich brings about the spread of infec­tious agents or dyes in the skin of rabbits.Chain and Duthie showed that this ac­tivity was probably identical with the en­zyme hyaluronidase previously describedby Meyer and co-workers.The polysaccharide hyaluronic acidwas first prepared from vitreous humourand is probably identical with the groundsubstance of the mesenchyme. Its pres­ence has been demonstrated in synovialfluid, in umbilical cord, in skin, in Graf­fian follicle, and in the capsule of certainstrains of streptococci. Hyaluronic acid isis of large molecular weight and containsequimolecular amounts of the mono­saccharides, N -acetyl glucoseamine andglucuronic acid. The manner in whichthese are bound together is unknown.The enzyme hyaluronidase has beendemonstrated in testicular extract, insnake venom, in leech heads, and in fil­trates of a number of microorganisms in­cluding streptococci, pneumococci, ct.uelchii, and staphylococci. This enzymehas so far not been prepared in pure formand its exact mechanism of action on hya­luronic acid is unknown, although it isknown that it brings about a marked re­duction in the viscosity of hyaluronic acidMEDICAL ALUMNI BULLETIN 5itions and a reduction of the ability of.luronic acid to combine with protein.ese changes are utilized for the quanti­.ve determination of the enzyme. Thelity of hyaluronidase to produce theeading reaction suggests it has a simi­action in vivo.�cClean discovered the occurrence ofnhibitor of hyaluronidase in the bloodnumber of mammalian species. This is.inct from the specific antibodies thatbe produced by immunization withcific hyaluronidases. The role playedthis inhibitor in the physiology of con­tive tissue is still obscure. Its level isarently nonspecifically increased in aI aber of infectious diseases. The con­tration of this inhibitor is lower in theid of young adult males than in fe­es, children, or older males. It has re­tly been demonstrated that magnesi­is required for the action of the in­.tor.�any investigators have speculated as. he possible relationship between thenges brought about by hyaluronidasethe changes that occur in variousases of connective tissue, particularly.rmatic fever. These speculations have. the most part been based on the fol­ing facts: (I) hyaluronic acid is a com­ent of connective tissue; (2) salicyl­i have been demonstrated to inhibitspreading reaction; and (3) hyaluron­. cid and hyaluronidase are producedmany strains of streptococci. Therehowever, been no direct proof of thei tionship of this enzyme to the patho­esis of rheumatic fever..Iyaluronidase has been applied clini­y to speed the absorption of subcu­eous fluids and of various drugs. The!. /me has been reported to increase the>� iency of local anesthesia. The use ofluronidase in the treatment of humani rtility has now been largely dis­c'lited.,vhile there is no direct proof of theof hyaluronic acid and hyaluronidase.he pathogenesis of disturbances of1ective tissue, it would seem to be. cally sound to expect that a bettererstanding of this phase of the physi­;y and chemistry of connective tissuerj ht be of value in elucidating the naturehese enigmatic diseases.chard Landau, New Directorof the Clinical ChemistryLaboratory)r. Richard L. Landau, Assistant Pro­or in the Department of Medicine, has!11 over the direction of the Clinical'mistry Laboratory. Dr. Landau1t1 luated from Washington University in51 Louis and received his M.D. degreet.·e in 1940. He interned at the Univer­si of Chicago Clinics and followed this.... 1 an assistant residency in the Depart­� It of Medicine. In 1942 he was made�:13tant in the Department of MedicinefI,.j ch position he held until he entered the Army in 1943. Dr. Landau saw serv­ice with the Fortieth Infantry Division inNew Britain, the Philippine Islands, andKorea. He returned to the University inLANDAU1946 as instructor in the Department ofMedicine and was promoted to AssistantProfessor in 1948. Since completing his as­sistant residency Dr. Landau has been as­sociated with Dr. Allan T. Kenyon in theEndocrinology Clinic and has workedwith Dr. Kenyon on the anabolic effectsof steroid and pituitary hormones. He hasalso studied the urinary excretion of the17 - Ketosteroids and various fractionsthereof as a means of elucidating steroidmetabolism and its relationship to theprocess of growth.Dr. Landau is a member of the Associ­ation for the Study of Internal Secretions.Donald McDonald ReceivesAppointment at the Universityof WashingtonDr. Donald McDonald, class of '44,has been appointed assistant professor inthe Department of Surgery at the Univer­sity of Washington School of Medicine inMcDONALD Seattle, Washington. He will be in chargeof the Urology Section there under Dr.Henry N. Harkins, professor of surgery.The latter is also a former member of theresident staff of The Clinics. Dr. McDon­ald was born in Chicago Heights, Illinois,and did both his undergraduate andmedical work at the University of Chica­go. He received the M.D. degree in 1944and followed this with an internship andresidency at The Clinics. He saw servicein the Navy in 1945 and 1946, returning toChicago in August, 1946, as an Instructorin Surgery under Dr. Charles B.. Huggins.Dr. McDonald has done research under aDouglas Smith Foundation Fellowship.His work has included studies of variousurological conditions, work on surgicaltechniques, and the observation that {3-glucuronidase activity is increased intoxemias of pregnancy. With Dr. Don­ald goes Mrs. McDonald, the former Vir­ginia Vail, M.D., class of '44, and recentlyassistant resident in the Department ofPediatrics at The Clinics .BIRTHSDr. and Mrs. J. M. Dondanville-SharonIsabel, Sept. 2, 1948 .Mr. and Mrs. L. P. Tuttle (Dr. Gertrude Fox)-Mary Ann, Oct. 1948.Dr. and Mrs. Albert Dorfman-Julie, Jan. 4,1949·Dr. and Mrs. Glen T. Smith-Christine Ann,Jan. 9 .Dr. and Mrs. Harwell Wilson-MargaretMarie, Jan. 25.Dr. and Mrs. Leo Rangell-Richard Neal,Jan·30.Dr. and Mrs. Arthur Seski-Hedwig Ann,Jan·30.Dr. and Mrs. Robert Schmitz-Marie, Feb. 3.Dr. and Mrs. James Loucks-Lynne Eliza­beth, Feb. 6.Dr. and Mrs. Jay P. Bartlett-Sara Louise,Feb. 14.'Dr. and Mrs. Jerry Gans-Beverly Ann,Feb.18.Dr. and Mrs. Frederick Owens, Jr.-Helen,Feb. 22.Dr. and Mrs. Matthew Block-Richard An­thony, Feb. 28.Dr. and Mrs. Julian Tobias-Michael Da­mian, March I .Dr. and Mrs. Stanley Moulton-CarolLouise, March 2.Dr. and Mrs. Julian Buser-Lawrence Wil­liam, March 2.Dr. and Mrs. Clarence Lushbaugh-RobertChism, March 4.Dr. and Mrs. Gustave Freeman-Phyllis,March 5.Dr. and Mrs. Frank J. Orland-Carl Philip,March 9.Dr. and Mrs. Max Briggs-Paula, March 13.Dr. and Mrs. Frank M. Johnson-BruceAlan, March 17.Dr. and Mrs. Richard Landau-James Rich­ard, March 26.MARRIAGESDr. Wallace G. McCune-Fay Gaugler,June 30, 1948.Dr. David Minard-Sally Zimmermann, Au­gust 2I, 1948 .Dr. Richard Elghammer-Margaret Watkins,March 30, 1949.Dr. James S. Clark-Dr. Maxine Y. Taylor,April 9, 1949·6 MEDICAL ALUMNI BULLETINALUMNI NEWS'32. John H. Glynn had a book publishedin October, 1948, entitled The Story of Blood,which, he says, is written for intelligent peo­ple who ask questions about blood and wantnontechnical answers.'34. James W. Hall was an instructor inmedicine at Northwestern University from1937 until 1941 when he entered the service.He was separated with the rank of colonel in1946 and is now chairman of the Departmentof Medicine at the James Decker MunsonHospital in Traverse City, Michigan.Herman P. Harms was released fromactive duty in April, 1946, with the rank ofcommander at which time he returned to hispractice in Holland, Michigan.'36. Harry E. Brown, who entered privatepractice in 1946 in Santa Barbara, California,writes that he is keeping busy as a generalpractitioner in a town of specialists. TheBrowns now have two children, Barbara,nine, and David, seven., 37. Ruth Aaron writes that her interestsare divided between her gynecological prac­tice and her two sons, aged six and four. Herhusband, Dr. Oscar Auerbach, is practicingsurgery after five years in the Army. Duringthe last few years Dr. Aaron has spent a lotof time giving a series of lectures to parentson the emotional development of children andthe problems of marriage to groups of youngpeople.Mabel Blake Cohen is practicing psycho­analysis half-time in Washington and raisingher two children, aged four and three, the restof the time. Her husband, Dr. Robert Cohen,'35, is chief administrator and psychothera­pist at Chestnut Lodge Sanitarium in Ro­chelle, doing work for the Navy in additionto consultation work.Gertrude Fox is practicing part time, withparticular emphasis on diseases of the chest,in Glendale, Illinois.Joan Fleming has been appointed assist­ant professor of psychiatry at the Universityof Illinois College of Medicine.'40. Philip Clark, from the Department ofSurgery of the University of Kansas, visitedThe Clinics in February.Walter W. Hamburger has been at StrongMemorial Hospital since July, 1946, and iscurrently instructor in psychiatry and chiefof the Out-Patient Psychiatry Clinic. He andhis wife, the former Ruth Kraft, who re­ceived her M.A. degree in social work at theUniversity of Chicago in 1942, have a one-year-old son, John. 'Karl M. Lacer is still in the Navy and sta­tioned at the San Diego Naval Hospital. Heexpects to take his internal medicine hoardexaminations next year, Dr. Lacer recentlysaw Dick Lambert, '40, at one of the medicalmeetings. Dick is practicing orthopedic sur­gery in San Diego.Roland C. Olsson recently completed atwo-and-a-half-year residency at the VeteransAdministration Hospital in Hines, Illinois.At present he is doing part-time medical workfor Sears Roebuck and Company in Chicagoand getting a private practice started in in­ternal medicine.James L. Waters, who has been out of theNavy a little over a year, finds private prac­tice much more to his liking and is kept busyin his spare time by his three children., 4[. Milton F. Leeds recently entered the private practice of internal medicine in SanFrancisco. Prior to this he was a resident inpsychiatry at the Langley Porter Clinic inSan Francisco and a resident in medicine atthe Huntington Memorial Hospital in Pasa­dena.William C. Lewis was certified in psychia­try in December, 1948. He is now on the staffof the Winter Veterans Administration Hos­pital in Topeka, Kansas, as well as on thefaculty of the Menninger Foundation Schoolof Psychiatry. Dr. Lewis is also engaged intraining at Topeka Institute for Psycho­analysis. The Lewises now have four sons.David Lochman has been made instructorin the Department of Roentgenology at TheClinics.Mary Sherman, Assistant Professor ofSurgery at The Clinics, spoke on "OsteoidOsteoma" at the February meeting of theChicago Rheumatism Society.'42. James H. Billings at the present timehas a full-time appointment as associate ra­diologist at Cedars of Lebanon Hospital inLos Angeles.Robert P. Hall served with the Navy fromJuly, 1942, to July, 1947. Since his releasefrom the service he has been in the privatepractice of medicine in Sunnyside, Wash­ington.James A. McClintock is chief resident insurgery at the University of Louisville Schoolof Medicine. As of July 1,1949, he will beginprivate practice in Muncie, Indiana.'43. George G. Beattie has just begun ayear of residency training in orthopedic sur­gery at the Childrens' Hospital in Bostonunder the Navy graduate training program.He left the U.S. Naval Hospital at St. Albansearly in December after twenty-one monthson the orthopedic service there.Byron L. Casey is in part-time privatepractice of psychiatry and part time with theVeterans Administration in Detroit, Michi­gan. The Caseys now have two children.Walter D. Davis, who was married inJune, 1947, to Thecla Lunger, has for the lasttwo years been working toward his specialtyboard in psychiatry at the Norristown StateHospital, Norristown, Pennsylvania.Richey F. Dodds is just beginning privategeneral practice in Brantley, Alabama. Afterleaving the Navy in July, 1947, he worked ina Veterans Hospital nine months and thenhad a nine-month general residency at Lynch­burg General Hospital in Virginia, which hefinished in January.Joseph M. Dondanville, resident in anes­thesiology at the Lahey Clinic, visited TheClinics in January. On April 1 he became di­rector of anesthesiology at the Henry FordHospital in Detroit.Grace B. Goebel has been practicing inMarin County, California, for severalmonths.Robert M. McCormack was a Januaryvisitor to The Clinics. By July he will havecompleted a residency in plastic surgery atStrong Memorial Hospital of the Universityof Rochester, Rochester, New York.Wallace G. McCune finished his residencyin internal medicine at Jefferson Medical Col­lege Hospital in January and entered thepractice of medicine in Washington, Pennsyl­vania.David Minard is at present serving as head of the physiology facility at the NavMedical Research Institute.William E. Reynolds was separated frothe service in August, 1948, and since thtime has been working for a M.P.H. at tHarvard School of Public Health. He S4:Herbert Domke, '42, who is a research assciate in biostatistics at the School.Stanford K. Sweany is a member of t'staff of the Ottawa Tuberculosis Sanatoriuin Ottawa, Illinois. Ralph J. Bailey, '43,practicing roentgenology in the same city.'44. Hugh A. Frank will begin a surgkresidency at Birmingham General HospitVan Nuys, California, on July I, 1949.John F. Kenward became Chief Resideand Instructor in Pediatrics on April IThe Clinics.Morton L. Pearce recently brought tAssociation up to date on his activities singraduation. He took a nine-month rotatiinternship at the Los Angeles General H<pital, followed by a three-year residencyinternal medicine, which he recently finish!He is at present engaged in a research pigram with the Hematology Section of tAtomic Energy Project at the UniversityCalifornia at Los Angeles. Dr. Pearce is m:ried and has two children.Paul F. Wallace, who served as ward 01cer with the 97th. General Hospital in Fratfort, Germany, during 1946 and chief of torthopedic service at the Percy Jones Gemal Hospital from 1946 to 1948, is now an Istructor in orthopedic surgery at the Univisity of Michigan, Ann Arbor.'45. Mame Cataldo, who was a residentradiology at The Clinics from July, 1948,January, 1949, is presently pursuing a t�and-a-half-year residency in internal mecine at Cook County Hospital.Anthony Pizzo is a resident in pathologyPassavant Memorial Hospital in ChicuThe Pizzoes have a fourteen-month-old s<Angelo John.Jerome Styrt, who went to the RetreatYork, England, in June, 1948, as assistamedical officer, is now staff psychiatristBelmont Hospital, a neurosis center in S'ton, Surrey. Following his internship at 1Clinics in 1946 he served a residency at ISheppard and Enoch Pratt Hospital in T<son, Maryland, a psychiatric hospital. Flowing this he attended courses at the Waington School of Psychiatry in WashingfD.C., and had his first year of psychoanalytraining at the Baltimore PsychoanalytiInstitute in 1947 and 1948. He and his wthe former Miss Mary Onken, who was stpsychologist with Miss Elonen in Bobs R,erts Hospital, plan to return to the stafrom England in July of this year.'46. Edward Senz recently returned freight months of duty in China and Japan 3is now eagerly looking forward to his relefrom the Navy.Paul E. Zuelke, who is stationed at FKnox, Kentucky, and Crawford CampbellAlbany, New York, former resident in ortpedics, visited The Clinics in January wIthey were taking the examinations ofAmerican Board of Orthopedic Surgery.'47. Frank B. Kelly is an intern in pat)ogy at the Presbyterian Hospital in ChicaOlaf Skinsnes and his family will lesoon for China, where he will serve as a ID'MEDICAL ALUMNI BULLETIN 7I missionary under the Lutheran Unitedission.Thomas Tourlentes is at Downey, Illinois,·terans Hospital near Great Lakes pursuingycbiatric residency training under the di­:tion of Dr. Jules Masserrnan, formerly on� staff at Tile Clinics.'48. Ernst R. Jaffe writes that he is getting.0 tbe swing of being a medical intern atesbyterian Hospital in New York and isjoying his work very much. He sees DelrgenstaI, '47, frequently and also DirkIIJlwood, '48, who is interning at New Yorksspital.Allan D. Rosenblatt is interning at Los.geles County Hospital. In July he will.rt a residency in psychiatry at Bellevue-spital in New York. He expects to takeiduate training there and also at the Co­nbia University Psychoanalytic Institutetraining and research.Paul S .. Russell writes that he is enjoyinginternship at the Massachusetts General'spital. He is now on the urology serviceere he works on a twenty-seven-bed ward.The Editors know now whatprompted the senator from NorthCarolina to say to the senator fromSouth Carolina what he is reported tohave said, or was it the senator fromSouth Carolina who said it to the sena­tor from North Carolina. Anyway,after putting Charleston, South Caro­lina, in North Carolina the Editorsneed another something.()yne-(Cont. from page 3).tbooks, Dr. Hoyne is a past presidentthe Chicago Pediatric Society and iss year vice-president of the Institute ofxlicine of Chicago. He is a Fellow of! American College of Physicians andthe American Academy of Pediatrics.is an honorary member of the Socie­:I Mexicana de Pediatria and of the:iedad Cubana de Pediatria. In 1942. Hoyne received a citation for Public. vice from the Alumni Association of!. University of Chicago.'CHOOL OF MEDICINEoL.5 SPRING 1949 No 3CHAIILES L. DUNHAM, EditorHUBERTA LIVINGSTONE, Associate EditorROBERT H. EBERT, Associate EditorHENIIY T. RICKEITSCLA YTON G. LooSLILEON O. JACOBSONM.mber. of Ih. Editorial BoardMAillE]. EcKEIIT, S.".I6,y-ice of yearly subscription (or nonmembers, $[ .00;ice 01 single copies, 25 cents. Recent Graduate Appointedto Staff of Los Alamos ScientificLaboratoriesDr. Clarence C. Lushbaugh, M.D.University of Chicago 1948, and Assist­ant Professor in the Department ofPathology, has been appointed staff mem­ber of the Los Alamos Scientific Labora­tories, .University of California at LosAlamos, New Mexico, and pathologist ofthe Los Alamos Hospital. Dr. Lushbaughreceived the B.S. degree from the Univer­sity of Chicago in 1938, the Ph.D. degreein pathology in 1942, and his M.D. de­gree this past year. He has worked con­tinuously in the Department of Pathol­ogy since 1938. beginning with a ServiceLUSHBAUGHScholarship and continuing as an assist­ant from 1940 to 1942 and instructor to1947, at which time he was made an As­sistant Professor. Along with others work­ing in the Toxicity Laboratory during thewar, Dr. Lushbaugh made pioneer ob­servations on the leukopenic effects ofnitrogen mustard and the applicabilityof these substances to the treatment ofleukemia.U. of C. Scientists Take Part inOak Ridge MeetingThe Biology Information Meeting heldat the Oak Ridge National Laboratory,Oak Ridge, Tennessee, the week of AprilII was well attended by U. of C. scien­tists. The Institute of Radiobiology andBiophysics of the University of Chicagowas represented by Robert D. Boche,Aaron Novich, Leo Axilard, and Ray­mond E. Zirkle, who presented a paperentitled "One-Hit and Two-Hit SurvivalCurves Resulting from Alpha- and X­Radiation of Aspergillus Spores," and byDr. Austin M. Brues, who spoke on "Per­manent Levels of C-14 and H-3 in Man."Among others who attended from theUniversity were Dr. Julius M. Coon,Kenneth P. DuBois, John F. Thompson,Dr. Robert J. Hasterlik, Dr. C. PhillipMiller, Robert N. Feinstein, and Dr.Franklin C. McLean. Senior Scientific SessionThe Annual Senior Scientific Sessionsponsored by the Medical Alumni Asso­ciation took place in P-I 1 7 on March 17.Dr. Leon O. Jacobson presided. Like lastyear, the caliber of the papers presentedwas excellent. Included on the programwas a presentation by Albert Sjoerdsmaof "Study Relating the Action of Digi­toxin to Histamine Metabolism," whichwon the Borden Prize Award of $500. TheSJOERDSMAEditors hope to publish this material inan early issue of the BULLETIN. The com­plete list of titles follows: "The Rate ofConversion of Administered InorganicRadioiodine into Protein-bound Iodine ofPlasma as an Aid in the Clinical Evalua­tion of Thyroid Function," by EvelynAdams; "The Determination of the Mini­mal Daily Amino Acid Requirements forthe Protein-depleted Adult Male AlbinoRat," by C. Harold Steffee; "Researcheson the Thymus Gland," by Vaughn P .Simmons; "Hypothermia in the Mouse­Applied to the Bio-Assay of the Endo­toxin Protection Factor of Impure Peni­ciliin," by William H. Anderson; "TheExperimental Production of Hemorrhagein Dogs with the Use of Aminopterin andIts Control with Toluidine Blue," by Bur­ton J. Grossman; "Defective Thermo­coagulation in Cancer," by Gerald M.Miller; "Vitamin Deficiency and ProteinSynthesis with Special Reference to Ribo­flavin Protein Interrelationships," byRobert W. Wissler; "An A.C. Measure­ment System for Mass Spectrometers,"by Robert Dowben; "The MenstrualCycle as Reflected by Oral, Vaginal, andNasal Smears in the Human," by MichaelSpirtos; and "Studies on Bone-MarrowMetabolism," by Arthur Wendel. Imme­diately after the Scientific Session thesenior class put on a skit in the form of afabulous Wednesday afternoon clinicalconference-all of which served to provethat this class. in addition to having madea good start toward advancing the scienceof medicine, has an excellent sense ofhumor.8 MEDICAL ALUMNI BULLETINASSOCIATION ACTIVITIES IIN THIS ISSUE IWARNER, CUNNINGHAM, HODGES, JACOBSONBAILEY, COGGESHALLFaculty-Graduating ClassBanquetThe annual banquet in honor of thesenior class was again sponsored by theMedical Alumni Association and was at­tended by a hundred and seventy mem­bers and prospective members of the As­sociation. The banquet was held in theLouis XVI Room of the Shoreland Hotelthe evening of March 17. Members of thesenior class and the majority of the res i­.lcnt staff of The Clinics were guests of.he University. Dr. Leon O. Jacobson,president of the Medical Alumni Associa­tion, presided. Dr. Paul C. Hodges did anartful job as toastmaster and awarded"Oscars" in the form of dolls to Drs. Ar­comano and Dowben for superior im­personations in the class skit. The speak­er.of the occasion was Dr. Percival Bailey, professor of neurosurgery at the Univer­sity of Illinois and for eleven years chiefof the neurosurgery section at the Univer­sity of Chicago. Dr. Bailey told of themany vicissitudes, both humorous andotherwise, which beset his trip across thePacific to the Philippines and Japan asspecial consultant for the Army MedicalCorps. Dr. Coggeshall presented theBorden Prize Award to Dr. AlbertSjoerdsma (see article on the Senior Sci­entific Session). Dr. Nancy Warner, sub­stituting for the class chancellor, Dr. Wil­liam Forney, spoke a few well-chosenwords on behalf of the graduating class.Mr. James A. Cunningham, Vice-Presi­dent of the University in Charge of Busi­ness Affairs, was an honored guest. Thedinner was preceded by the usual cocktailand social hour which served to set thepace for the evening.ANNUAL FACULTY-STUDENT BANQUET Briefly announced in the Winter Issthe Argonne Cancer Hospital takes 0'the front page. In this issue is a feati. article on the Student Health Serviwhich was for many years the stepchildThe Clinics. It is now fully integralwith the activities of the School of Mecine. The activities of the Associationbehalf of the graduating class are ,scribed. These include the Senior StudtScientific Program and the annual bsquet, both sponsored by the Associati­In the Scientific Section Dr. John F. Pkins describes cooling as a stimulussmooth muscle activity, while Dr. AlbDorfman brings us up to date on the stject of hyaluronidase.QUESTIONNAIREWe are again inclosing with each BtLETIN a copy of the questionnaire sent (with the last issue and urge those whave not done so to take time out toit in. We have received 241 completquestionnaires to date, 168 of these fngraduates. Thus the return so far is �proximately 20 per cent. To have the dsmean anything, we will have to do betthan that. Please send your questicnaire in promptly.Atlantic City MeetingIt is hoped that there will be enouinterest among alumni so that a get­gether luncheon can be held at AtlanCity at the time of the A.M.A. Convetion. Those who arc interested in sudmeeting should contact the secretarythe Medical Alumni Association so thif the interest warrants it, advance pre(rations can be made.Announcement of Annual Meeing and Election of Officersfor 1949-50We are inclosing with this issue tballot for the annual election of officers 1the Association for the year 1949-�with the recommendations of the Nonnating Committee. The Spring Meeti Iof the Senate of the Medical Alumni Psociation will take place in Room M-lat 5:00 P.M. on Friday, June 17. Imrrdiately following this meeting of tSenate, at 5:15 P.M., in the same roo:there will be the annual meeting of tAlumni Association. All alumni who cdo so are urged to attend.