rJulletm <ItIw Ji/umnt. �ocial«m·CHOOl OF MEDICINEN 1 V E R S T YVolume 2 o F C H C A °6 0JANUARY 1946 Number 1The Institute ofRadiobiology and BiophysicsThe Institute of Radiobiology andBiophysics is being organized in the Division of Biological Sciences to conductoasic research on the biological effects ofradiations, with special reference toX-rays and other ionizing radiations, and.n the broad field of general biophysics.It is expected ultimately to include somejfteen investigators of academic rank,.nost of whom will be new members of theUniversity. Most of the prospective mernoers still have war research to finish andwill join the Institute about July I, 1946.The investigative staff will consist ofndividuals trained in diverse fields of theriological and physical sciences. This dizersity of personnel will make it possible,n attacking each radiobiological or bioihysical problem, to form a suitable teamJf investigators. It is anticipated that such.eams may frequently include members of:he present Departments as well as merniers of the Institute.Although the Institute will offer no:ourses and confer no degrees, it is anticiiated that suitably qualified graduatetudents may be trained in either radioiiology or biophysics by co-operative arangements between the Institute and theiertinent teaching Departments in the) ivision of Biological Sciences and theJivision of Physical Sciences.Until a new building can be constructd, temporary quarters on or near the:ampus will be used.The Institute will be equipped withources of X-rays, neutrons, and otheronizing radiations and with equipmentor handling radioactive substances of'arious sorts. Facilities for the use ofsotopic tracers, both radioactive and. table, are planned. An extensive program.,f research on the biophysics of nerve and,f membranes is anticipated. The elecIonic and other equipment for such in'estigations will be available. The invest iation of the physical structure and phys::al activities of other biological systemslill be developed.The Institute is being organized underhe direction of Raymond E. Zirkle, Proessor of Botany. The remainder of thetatI will be announced at a later date. JACOBSONDEAN JACOBSONLeon Jacobson, M.D. 1939, and sincehis medical student days a member of thestaff of the University, has become Associate Dean of the Division of BiologicalSciences. Dr. Jacobson was born inSimms, North Dakota, on December 16,191 I. He was educated at the Almont(N.D.) High School, North Dakota StateUniversity, and the University of ChicagoSchool of Medicine. He interned in medicine with Dr. Dick and served his assistant residency here. Subsequently he became Instructor in Medicine, with hisspecial efforts devoted to hematology. In1942 he joined the "Metallurgy" project,becoming Associate Director of Health.Here he was concerned with the protection of personnel from the hazards of radiation and with the study of the physiological effects of the products of pileoperations. Those who know him have nodifficulty in heartily wishing him well inhis new tasks.Editor of Bulletin RetiresDr. Francis Gordon has retired asEditor of the BULLETIN. This is most unfortunate. The alumni and faculty join inthanking him for his services and hopethey can get along without him. Deferment of Interns andResidentsFollowing is an abstract of an announcement by the Procurement and Assignment Service, dated November 6,1945:"The 9-9-9 Program must be reconverted as rapidly as possible. The Surgeon General expects to call to activeduty as rapidly as possible every commissioned officer serving as a resident and,therefore, veterans will represent practically the only source of supply withwhich to fill residencies ..... Hospitals,therefore, must begin at once to appointveterans to every staff position so that,with rare exceptions, every military resident can be called to active duty not laterthan April I, 1946 ..... At present veterans will not count in hospital quotas..... Hospitals and commissioned officersnow serving as residents are remindedthat any contract with hospitals is whollysubsidiary to their legal obligation to theArmy and Navy, and that each individualis subject to active duty orders at thediscretion of the Surgeons General. ...."In those cases where the hospital desires the services of an officer on activeduty in the Army to fill a residency andthe hospital is willing to release a deferredcommission resident who has not been onactive duty before the termination of hispresent deferment period in exchange andhe is an officer (I) who has been on activeduty for two years or more, (2) who isnow stationed within continental UnitedStates, and (3) who would accept the appointment, a request for the release ofthat officer under War Department Circular 296 through the Procurement andAssignment Service will receive immediately prompt and favorable considerationby the Surgeon General of the Army _ Thisreplacement possibility does not extend toofficers on duty with the Navy ....."Subject to the above general provisions the reconversion from the 9-9-9 Program to a peacetime twelve-month service will be conducted in accordance withthe following plan: (This outline appliesto the April group. Information concerning those who finish their present termbefore April and after April will be released in the very near future.)(Continued on page 2)2 MEDICAL ALUMNI BULLETIN�ltxanbtr "tnrp Dabis1906·1945The Class of '31 mourns the loss of"Sandy" Davis, who was killed by enemyaction on April 28, 1945.Since the completion of his training onthe resident staff of the Department ofSurgery in 1932, Sandy had been in practice in Chicago, cunfining his interest toradium therapy. In September, 1942, hevolunteered his services to the Navy, reporting for duty December 10, 1942, atthe U.S. Naval Hospital in San Diego.Here he worked in surgery and was incharge of a ward.On Christmas Eve, 1943, he reportedfor duty aboard the U.S.S. "Pinkney," anauxiliary hospital and transport ship,and lived and worked aboard her for ayear and four months. For the most parthe was assigned to surgery.Sandy first saw action at Peleliu, thenat Leyte, Lingayen Gulf, Iwo jima, and,finally, at Okinawa. Lying off the KemeraRitto group southwest of Okinawa, the"Pinkney" was hit by a kamikaze. In addition to Sandy, three physicians andabout forty other men lost their lives.We remember his warm personality,his brilliance as a student, his ability andunderstanding as a physician. We wish topay sincere homage for the supreme sacrifice he made in the interests of his fellowman and to extend to his widow, Josephine, his daughter, Susan, and his son,Stephen, our most sincere sympathy. DAVISVOLKE 1Dr. 1i!lalttr �Olkt1910·1945Walter Volke, M.D., Chicago, Illinois, died October 25 at Billings Hospital of coronary occlusion. He was bornMarch 28, 1910, in Bovey, Minnesota.Graduating from the University of Minnesota with the degree of Bachelor ofScience, Dr. Volke attended the University of Pennsylvania, where he wasawarded a research scholarship to theUniversity of Chicago. He received hisM.D. at the University of Chicago withthe class of 1939. After interning atEnglewood Hospital, he served as an epidemiologist with the Chicago Board ofHealth. Survivors include his mother,Mrs. Margaret Volke, two sisters, Mrs.Edith Chaput and Mrs. Nels Johnson,and one brother, George Jackewitz.EpilogueOn the wall of an old cottage in Bremenis a Latin inscription which, translated,reads: "Seafaring is necessary; living is notnecessary." In this spirit of meeting tirehazards of a dangerous calling MelbourneW. Boynton, Charles William Pfeiffer,William Dewey Davis, Milton B. Hansen,David B. Stewart, John Blythe, and Alexander Henry Davis, our former studentsand associates, have given their lives. Wewish once more to acknowledge and tomourn their loss.Defe rm_e nt-(Continued from page I)SECTION I"A. Each commissioned officer who isan intern terminating his nine months ofinternship on April I, 1946, will continuein his present internship until July I,1946. (For exceptions, see below.)"B. Each commissioned officer who isa junior resident terminating his juniorresidency on April I (if he has not alreadybeen replaced by a veteran prior to AprilI) will be called to active duty on April Iexcept in rare cases ....."c. Each commissioned officer who isa senior resident and who is completinghis 27 months of service in a hospital following graduation will be called to activeduty on or about April I, 1946, if not replaced prior to that date by a veteran."D. Senior students who graduate onor about April I, 1946, are to be acceptedfor internship on that date. This newgroup of interns will be allowed to serveinternships until July I, 1947. This meansthat hospitals would have a maximum oftwice their quota of interns from April toJuly and their quota of interns from JUlyto the following July. In view of this and inorder to maintain equitable distribution ofthe intern supply, quotas for interns will bemaintained at their present levels. SECTION II"A. The present interns (referred toin Paragraph A, Section I, above) will becalled to active duty on July I, 1946, except (I) those who are called to duty between April I and July I because the hospitals cannot facilitate both the old andnew groups of interns for three fullmonths of overlapping service; and (2)those rare cases where their services areabsolutely essential for an additional period in civilian hospitals ....."D. The new graduates (referred to inParagraph D, Section I, above), who willcomplete twelve months of internship onor before July I, 1947, will be called toactive duty on that date. These men mayhave as much as fifteen months of internship, that is, April I, 1946, to July I,1947."This program means that by April I,1946, hospitals will be almost entirely dependent upon nonmilitary personnel tofill residencies.The statement concludes: "We cannotemphasize too strongly the necessity ofreconverting from the 9-9-9 Program asrapidly as possible and to the greatest extent possible, for the purpose of returningto the July to July twelve-month internship this coming year."In accordance with the above regulations, the University of Chicago Clinics has canceled appointments for April I,1946, of assistant residents and residentswho hold reserve commissions and is nowselecting veterans for these positions.HENRY T. RICKETTSGORGAS MEDALCaptain Lowell T. Coggeshall (MC),USNR, formerly of the Department ofMedicine, received the Gorgas Medal onOctober 29, in Washington, D.C., "fordistinguished service to our militaryforces in establishing new principles inthe management of patients sufferingfrom psychic disturbances as well asphysical deterioration from the effects ofmalaria and filariasis." This medal hasbeen awarded annually since 1942 byWyeth, Inc., Philadelphia, and carrieswith it an honorarium of $500. The awardwas established in memory of SurgeonGeneral William Crawford Gorgas, U.S.Army.The Class of I945 is realizing a financial deficit of about $90.00. Any sugges'tions as to how it may be absolved will be,gratefully received by Warren Wilhelm'Secretary. IMEDICAL ALUMNI BULLETINSERVICE AWARDSMajor Myron M. Hipskind wasawarded the Bronze Star for meritoriousservice in connection with military operations in the European Theater of operations. He served as chief of the Eye, Ear,Nose, and Throat Section, 108th GeneralHospital. Major Hipskind has resumedhis pre-war practice at the WoodlawnHospital, Chicago.Lt. Raymond Malott (M.D. June '43)has recently been awarded the BronzeStar for his work in the Okinawa campaign, which consisted of rescue underfire of 600 casualties from ships struck bysuicide planes, bombs, and shell fire.Upon finishing his internship at IllinoisCentral Hospital in April, 1944, Lt. Malott entered the naval service. After abrief assignment at Great Lakes NavalTraining Station, he was assigned to ahospital ship. He was the medical officerin charge and participated in the campaigns of Leyte, Lingayan Gulf, and Okinawa. Back on a fifteen-day leave, he iswaiting a new assignment. Lt. Malott hasan eight-month-old daughter, Ruth Ann.Col. Paul A. Campbell, one of our firstsurgical interns, recently was made anHonorary Flight Surgeon of the FrenchAir Forces as a result of his work in aeromedical research. Col. Campbell was director of Aero-Medical Research of theA.A.F. School of Aviation Medicine, Randolph Field, Texas. He made two trips toGermany as a member of the intelligenceteam studying Air Force medical servicein Germany. Col. Campbell recently returned to private practice in Chicago.Lt. Col. Harwell Wilson, instructor inSurgery and Resident here in 1938-39,has been awarded the Legion of Merit forperformance of outstanding services onthe staff of the 225th Station Hospital,Mediterranean Theater. During the firstsixty days of the hospital's operations inItaly, Col. Wilson's Surgical Service Section treated nearly 4,000 combat casualties. His citation reads:Through unceasing and highly conscientious labors, and by virtue of his outstandingprofessional skill as a surgeon, marked devotion to duty, and high qualitiesof leadership,surgical care of the very highest order was afforded to thousands of patients, and an exceptionally low death rate was maintained.To Col. Wilson's tireless energy, leadership,and professional skill thousands of soldiers ofthe Allied Armies owe better health, and inmany cases, their lives.He is now on terminal leave and hasreturned to the Department of Surgery,University of Tennessee, Memphis.Lt. Col. Alfred Campbell Ledoux, whowas a member of our Roentgenology Department before going into practice inEvanston, was recently awarded theBronze Star. While chief of the X-rayService, 108th General Hospital, Lt. Col.Ledoux was instrumental in the discovery LEDOUXBECKER MALOTTHIPSKINDand the reconstitution and early adaptation of captured German X-ray and radiotherapy equipment, at a time whenthe transport of our own equipment wasextremely difficult and uncertain, owingto the exigencies of the military situation.Major Donald Cassels, Assist. Prof. ofPediatrics, has been awarded a BronzeStar for meritorious service in the shockand resuscitation wards of evacuationhospitals in France, Belgium, and Germany. He entered service in August,1943, and is now on terminal leave. MajorCassels wears five battle stars.Lt. (j.g.) Robert M. Becker, MarineCorps, class of June, 1943, has beenawarded the Bronze Star. The citationreads in part:For meritorious achievement in connection with operations against the Japaneseenemy while serving with a Marine infantrybattalion on Okinawa Shima, Ryukyu Islands ..... Through his untiring efforts, professional ability and coolness under enemyfire, his aid station was able to render immediate aid to those wounded and further insureexpeditious evacuation to the rear.His aid station was responsible for theefficient care of as many as 374 casualtiesin two assaults.NEW ASSISTANT TOALUMNI SECRETARYThrough the co-operation of the Deanof the Division, Miss Ruth Tiner has beenemployed as Assistant to the Secretaryof the Alumni Association with headquarters in Billings, A-II 2. All alumniand former members of the Clinics Staffare urged to send news and changes ofaddress to Miss Tiner. 3RESIDENT STAFFNEWSDr. Bruce Proctor, former resident inE.N.T., writes from Detroit that Dr. WilliamTuttle is back from the service wearing numerous citations and has resumed the practice of chest surgery in Detroit. Dr. Proctor'sson, now eleven years old, plans to come toDr. Lindsay in a few years for otolaryngological training.Lt. (j.g.) Robert Moore writes from Okinawa Shima. that the island has' been relativelyfree of diseases of much military importance.There is considerable tuberculosis among thenatives and some filariasis and Japanese encephalitis. B. Their chief problem at presentis casualties from vehicle accidents on themuddy and slippery roads. He has seen Crawford Campbell. Mrs. Moore and the boys areliving in California.Dr. Ernest Lyman Stebbins, former Billings surgical intern, and recently Commissioner of Health in New York City, has beenappointed professor of public health administration in the School of Hygiene and PublicHealth of the Johns Hopkins University, andassistant director of the school.Lt. Comdr. James Marron, USNR, wrotefrom Guam in October that he expects to beout of service in January. His ship had beenoperating in the Yellow Sea and the Gulf ofPoha supporting the occupation landings inNorth China and Korea. They had no mailfor a month, and it was believed blown awayin the typhoon at Okinawa.Dr. Frederick Kredel, who was Residentand Instructor in Surgery here in 1935-36 andnow Professor of Surgery at the Universityof South Carolina Medical School in Charleston, was a November visitor. He reports thathis brother Richard, who was formerly on ourresident staff, is now doing Xvray work forthe Navy in Okinawa.Capt. Don Ross, '39-'41, intern and asst.resident in orthopedics, has returned to theU. of C. as Veteran Resident in Orthopedics.He served in the entire European campaignas a member of an orthopedic auxiliary team.Thomas Gready, formerly at Lying-in,wrote Dr. Dieckmann in August of being inon the beach landings at Iwo Jima andOkinawa. He met Virginia Vail at Pearl Harbor, Ted Moffet on a fleet oiler, and Jampolissomewhere in the Pacific.Dr. Ruby K. Daniel, a member of ourophthalmology resident staff in 1932-34. isnow Asst. Clinical Professor of Ophthalmology, Southwestern Medical Foundation,Dallas, Texas.Maj. Thomas Weaver is being releasedfrom the Army and will enter practice inCincinnati, Ohio. His office will be in CarewTower, and his practice will be in the Jewishand Good Samaritan hospitals.The latest to be graduated from CarlisleBarracks were Chet Powell, a former residentin neurosurgery with Doctors Bailey andBucy; Ralph Victor, former resident in Medicine here; Roy Stanton '43; and ThomasMadden and Bino Marchello '44. Bino reported that Dr. Dick Trotter was staff officerof Carlisle Station Hospital and Dr. HelenTrotter, in lieu of pediatric practice, ran theentire laboratory facilities. It is said that allfuture A.U.S. classes for medical officers willgo to Fort Sam Houston, San Antonio,Texas.4 MEDICAL ALUMNI BULLETINSCIENTIFIC SECTIONDr. James S. Clarke, Assistant Residentin Surgery, has kindly summarized the workof Dr.Dragstedt, Dr. E. H. Storer, '45, and himself in the development of a new, radical, andrational surgical attack upon peptic ulcer. Dr.Thomas F. Gallagher, Associate Professor ofBiochemistry, traces his accom-plishment ofsynthesizing an adrenal cortical steroid with anoxygen on carbon-t i, Dr. H. P. Jenkinswrites of his work on the gelatin sponge, andDr. H. T. Ricketts com pels 1IS to face the depcncreatized man at long last.Vagus Denervation forPeptic UlcerThere is an imposing body of clinicaland experimental evidence supporting thethesis that acid gastric juice is a majorfactor in the genesis of benign duodenaland gastric ulcers. The mucous membraneof the stomach itself is digested by fundussecretion if this secretion is not neutralized or diluted by pyloric mucus, duodenal secretions, or food. Benign ulcersoccur only where gastrointestinal mucousmembrane is exposed to the action of acidparietal cell secretion, namely, in the loweresophagus, stomach, duodenum, jejunumopposite a gastroenterostomy stoma, andileum near the ectopic gastric mucosa ofa Meckel's diverticulum. The experimental production of ulcers in lower animals has been accomplished by effectingan abnormal increase in the volume andacidity of the gastric secretion or by interfering with the usual mechanismswhich neutralize that secretion. Prolonged stimulation of the stomach secretion by histamine in beeswax injected intramuscularly into dogs causes duodenalor gastric ulceration in a large percentageof cases. Jejunal ulcers develop when theduodenal secretions are diverted into theileum. An important part of the medicaltreatment of ulcers consists in the reduction or neutralization of acid gastric secretion.There is reason to believe that an excessive secretion of gastric juice occurs inmost ulcer patients. In dogs with vagaily innervated gastric pouches the acidsecretion of the pouches is greatly reduced by interruption of their vagal innervation. On the premise that the hypersecretion of the stomach in gastroduodenal ulcer is largely neurogenic inorigin, a series of patients with this disease has been treated by Dr. L. R. Dragstedt by an operation designed to removethe vagus innervation of the stomach.Studies have been made of gastric secretion and motility before and after theoperation.Bilateral section of the vagus nerveshas been done to date in 5 I patients forduodenal or gastric ulcer. Forty-two ofthese patients had duodenal ulcer, 2 had gastric ulcer, and 7 had gastrojejunalulcer. Transthoracic vagus section, approaching the vagus as it runs along theesophagus just above the diaphragm,was done in 39 patients. Transabdominalvagus section, cutting the right and leftvagi just below the diaphragm, was doneon 12 patients. Posterior gastroenterostomy was done in IS of these patients forhigh-grade pyloric stenosis, usually inconjunction with a transabdominal vagussection. The first of these operations performed here was done in January, 1943.A long period of observation is necessary before final conclusions can be drawnas to the merit of this procedure. Spacedoes not permit a complete discussion ofthe clinical results thus far obtained.With few exceptions, however, there hasbeen striking and complete relief of ulcersymptoms, the patients remaining well onunrestricted diets and without medication. In a number of cases spectacular recession in the ulcer craters has been observed roentgenographically.Studies on the effect of vagus sectionon gastric secretion indicate that it hasno effect on the secretory response of thestomach to histamine or caffeine butabolishes the stimulating effect of insulinhypoglycemia and a sham meal. In ulcerpatients there was an abnormally largecontinuous secretion of gastric juice inthe empty stomach at night when there isno apparent stimulus. Vagotomy reducedthis secretion from So to 60 per cent, indicating that it is largely neurogenic inorigin. The tonus and hunger contractionsof the stomach in patients with duodenalulcer, which are usually excessive, are reduced but not abolished by vagotomy.This work has been reported in A 11-nals of Surgery, 122:973, 1945·JAMES S. CLARKEA drenal SteroidsCertain striking biological activities ofthe hormones of the adrenal cortex, notably the effects upon carbohydratemetabolism, are associated with a chemical characteristic unique among the steroids of nature in that these substanceshave an atom of oxygen at carbon-r r ofthe ring system. The oxygen at carbon-r rof the adrenal cortical hormones is present as either a hydroxyl or a ketonegroup, and, because the neighboringgroups in the molecule partially maskthis position, the oxygen function ismarkedly resistant to the formation ofderivatives. Many attempts have beenmade to introduce oxygen at carbon-r rof the steroids as a necessary step preliminary to the synthesis of these hormones. These efforts have recently been successful both in Switzerland and in thiscountry.The starting material for the synthesisof the hormones was desoxycholic acidobtained from ox bile, since this compound has hydroxyl groups at both carbon-g and carbon-I2. In experiments carried out in this laboratory the hydroxylat 12 was oxidized to a ketone and theproduct brominated so that an atom ofhalogen was introduced at carbon-r r.This substance was then hydrolyzed to ahydroxy ketone and the ketone reducedto a methylene group. The product obtained had a hydroxyl group at carbon-r rbut in the opposite steric configuration tothat of the hormone corticosterone.The change in configuration was advantageous chemically, since the hydroxyl group formed derivatives readilyand could be protected in the furthermanipulations. The side chain of the bileacid was then degraded and the carbohydrate-like side chain of the cortical hormones introduced. Then the hydroxyl atcarbon-j was converted to a ketone group,and the double bond in ring A, which isessential for biological activity, was introduced. The product was the epimer atI I of corticosterone. Oxidation of thehydroxyl at I I yielded dehydrocorticosterone identical with the naturalproduct.Associated in the work, which wasdone under a contrac-t with the O.S.R.D.,were Drs. William P. Long, Vincent P.Hollander, Charles R. Marshall, andMiss Joanna Xenos.T. F. GALLAGHERGelatin SpongeOne of the recent advances in thetechnique of surgery has been the development of hemostatic substances. Inaddition to fibrin foam and oxidizedcellulose, there has recently been produced a gelatin sponge. Experiments havebeen conducted on the absorbability andhemostatic action of this gelatin spongeby Dr. James Clark and Dr. RudolphJanda, '44, in collaboration with Dr. H. P.Jenkins. It has been found that the gelatin sponge is absorbed in about a month.It is a relatively bland substance whichdoes not cause undue tissue reaction ifused in limited amounts.Furthermore, when the gelatin spongeis soaked in saline containing thrombinand applied to bleeding surfaces, a hemostatic effect is obtained on capillary andvenus oozing. It has been demonstratedthat bleeding from large wounds of theliver can be controlled with the gelatinsponge.H. P . JENKINSMEDICAL ALUMNI BULLETIN 5The Depancreatized ManDuring the last half-century an enormous amount of information concerning::Iiabetes has been obtained from the depancreatized dog. During the past fewyears the feasibility of total pancreatectomy in man has been demonstrated. Someof the pioneer studies in this field weremade in the University of Chicago Clinics, Previous experience with subtotal excision had shown that, as with the dog, itwas necessary to remove from 90 to 95oer cent of the organ before permanenthyperglycemia and glycosuria were produced. Recently five cases of "total" abla.ion of the pancreas had been reported'our for carcinoma and one for hypoglycemia. In the first case (Rockey, 1943),aowever, a remnant of pancreas weighingabout I gram was discovered at autopsy..I'he patient had survived 15 days. In the,second and third cases (Goldner andClark, 1944), the patients lived 10 and IIjays, respectively, after operation, and.iecropsy revealed no trace of pancreatictissue. The patient in the fourth case:Priestley, Comfort, and Radcliffe, 1944)was alive after 16 months at the time of.eporting. These patients required, afterrperation, from 27 to 50 units of insulinoer day.Ricketts, Brunschwig, and Knowlton:1945) have reported a fifth case in which.he patient died of recurrent carcinoma.hree months after operation and in which.he completeness of the pancreatectomyvas verified post mortem. This patient:liffered from the others in that he hadlad rather severe diabetes for severalnonths before operation, requiring fromto to 65 units of insulin daily. Also, thisseems to be the only reported case invhich the patient lived sufficiently longifter operation (3 months) to permit.ather extensive metabolic studies under.ontrolled conditions. Perhaps the mostnteresting observation was that the pa.ient needed no more insulin after comolete pancreatectomy, if anything somewhat less, than before operation. With an.ntake of 400 gm. carbohydrate per day,lis daily requirement was approximatelyto units. This dosage was in the range reoorted in the four preceding cases. Theseobservations imply that the insulin pro:luction of the normal human pancreas isorobably not more than 40 or 50 unitsdaily, a figure much lower than previousestimates, which had ranged as high as 200to 300 units. If a totally depancreatizedman requires no more than 40 units perday, it is apparent that any diabetic needing more than this amount must be suffering from something in addition to a pure. nsufficiencyof insulin. Such patients, requiring 60 to 100 units per day, are notrare, and even in patients with smallerrequirements it must now be questionedhow much of their need for insulin is dueto insulin deficiency and how much toextra-insular, anti-insulin factors.The patient showed a marked sensitivity to insulin in frequent hypoglycemic reactions, thus resembling the juvenilediabetic. Unlike that type of patient,however, the depancreatized man, whenmaintained on crystalline rather thanprotamine zinc insulin, had normal fasting blood sugars. When maintained onprotamine zinc insulin, which acts continuously throughout the 24 hours, andon a constant diet with equal feedingsevery 2 hours for 3 days, the blood sugarsshowed a characteristic diurnal pattern,with higher values during the day and adefinite downward trend during the night.This phenomenon, noted previously byothers, is thus shown to be independent offluctuations in insulin supply and is probably related to variations in the activityof the liver. Intravenous glucose tolerance tests were only moderately "diabetic." On two occasions, insulin and foodwere completely withdrawn and the DINratio of the urine was determined. Thiswas found to be 2-42 and 3.59, valueswhich are comparable to those obtainedin phloridzinized or completely pancreatectomized dogs and in severe, spontaneous diabetes in man. The withdrawalof insulin in each instance was followedpromptly by severe ketosis and markedhyperglycemia and glycosuria. On thesecond occasion, insulin was stopped permanently with a view to ending the patient's intense suffering from hopeless recurrence of his carcinoma. He died 6 dayslater in typical diabetic acidosis, with ablood sugar of 570 mg. per cent. This isthe first instance of which we are aware inwhich the essentiality of a hormone forhuman existence has been demonstratedby the removal of the gland manufacturing that hormone and the subsequentwithdrawal of replacement therapy.HENRY T. RICKETTSLIFE· MEMBERSHIPSJOHN E. ASHBY, M.D., res. staff, ped., '31-'33, now assist. prof., ped., Dallas, Texas.JOHN C. RANSMEIER, M.D., '37, Major, evac.hosp., instr. prevent. med., VanderbiltUniv.JOHN HENRY HEINEN, M.D. '41, Ph.D. '40,res. staff. surg., '41-'42, now Lt. U.S. Naval Research Lab., Anacostia Station,Washington, D.C.DUKE CHO CHOY, M.D., res. staff, ped., '43-'45, now Lt., AUS.L. SHERMAN JENNINGS, M.D. '40, Major,USAAF.PAUL F. WALLACE, M.D. '44, resident orth.surg., Medical College of Virginia, Richmond.JAMES S. CLARKE, M.D., res. staff, surg.,'44-'46.MELVIN NEWMAN, M.D. '44, assoc. ed., firstYear Book, now Lt. (j.g.), U.S. NavalHosp., Great Lakes, Ill.CLARENCE W. BLEDSOE, M.D. '37, Major389th Bomb. Group, now in practice Ob.& Gyn., 509 Med. Dent. Bldg., Seattle,Wash.WALTER LINCOLN PALMER, M.D. Rush '21,prof. Dept. Med. CHARLOTTE G. BABCOCK, M.D. '38, res. staff,instr., Psychiatry, now 8 S. MichiganAve., Chicago.WILLIAM E. ADAMS, M.D., res. staff, surg.,'28-' 35, now assoc. prof. surg.VIDA B. WENTZ, M.D. '35, Class Senator ofAssn., in practice, ped., 1718 E. 56th St.,Chicago.ABRAHAM W. MARCOVICH, M.D. '37, formerly assist. prof., roentgenology, now 60Wyoming St., Dayton, Ohio.CARL C. PFEIFFER, M.D. '37, prof. & chairman, dept. pharmacology, Univ. Ill. Col.Med .•WILLIAM J. HAND, M.D. '43, Class Senator ofAssn., resident, Ill. Cent. Hosp., Chicago.ROBERT P. HALL, M.D. '42, Lt. U.S. NavalHosp., Treasure Island, San FranciscoALBERT A. DAHLBERG, D.D.S., res. staff, .instr. dept. surg (dental), Lt. Comdr.,U.S.P.H.S., now 122 S. Michigan Ave.,Chicago.JACOB J. ZUIDEMA, M.D. '44, res. staff,E.N.T.ROBERT W. REID, M.D. '41, Lt. Comdr.U.S.S. "Mustin" (D.D. 413), f.p.o., SanFrancisco.THOMAS W. ANDERSON, M.D. '45, Lt. (j.g.),intern, U.S. Naval Hosp., Oakland, Calif.SOLOMON S. KAUVAR, M.D. '34, res. staff,med. practice int. med., 784 St. Paul St.,Denver, Col.JOHN H. MORTON, M.D., instr. Ob. & Gyn.,Lt. Comdr. U.S.N. Hosp., Jacksonville,Fla.LUCIUS W. WIMBY, M.D. '42, in practice int.med., staff of Provident Hosp., Chicago.BYRON F. FRANCIS. M.D., former assist. prof.med., now at Riverton Hosp., Seattle,Wash.JACK 1. WOOLF, M.D., instr. neurosurgery.MAXIMILIAN E. OBERMAYER, M.D., formerassist. prof. derm., now 2007 WilshireBlvd., Los Angeles. _HENRIETTA HERBOLSHEIMER, M.D. '38,Chief, Div. Maternal & Child Hygiene,Ill. Dept. Pub. Health; Exec. Sec. Governors Advisory Council on Hospitals.FRANK NEUWELT, M.D. '36, 504 Broadway,Gary, Ind.JOHN W. FINDLEY, JR. M.D., Lt., U.S.N.R.,210 Morgan St., Crawfordsville, Ind.ANNA HAMANN', M.D., assist. prof. roentgenology.STEWART F. TAYLOR, M.D. '45, intern, St.Luke's Hosp., Chicago.VICTOR JOHNSON, M.D. '39, pres. of Assn.,prof. lect. physiol; sec., Council on Med.Education, A.M.A.HARRY GORDON HEANEY, M.D. '34, Capt.aux. surg. team, now in practice, surg.,Corpus Christi, Texas.SAM W. BANKS, M.D. '34, pres. of Assn.,'36-'37, Lt. Col., Wakeman Gen. Hosp.,Camp Atterbury, Ind.EGBERT H. FELL, M.D. '32, Lt. Col. r jthGen. Hosp., now surg. staff, PresbyterianHosp., Chicago.MORTON LEE PEARCE, M.D. '44, resident,med., Los Angeles Gen. Hosp .ALFRED C. LEDOUX, M.D., res. staff, instr.radiology, now 121 I Mulford St., Evanston, Ill.WARREN K. WILNER, M.D. '45, int., Presbyterian Hosp., Chicago.RUBY K. DANIEL, M.D., res. staff, Ophth.,'32-'34, now 921 Med. Arts Bldg., Dallas,Texas.ROBERT C. WEBER, M.D., res. staff, Path.6 MEDICAL ALUMNI BULLETINALUMNI NEWS'32. Capt. Arthur J. Vorwald visited theU. of C. in November. He has been in theNavy since January, 1942. Following 18months as Chief of Pathology at the U.S.Naval Hospital in Annapolis, he spent 12months in the Research Division of the Bureau of Medicine and Surgery. After a yearas Naval Medical Representative at the U.S.Embassy in London, he returned to Washington, D.C., where he is now Head of theMedical Science Section, Office of Researchand Inventions, in the Office of the Secretaryof the Navy.BURT VORWALD'35. Capt. G. M. Wilcoxon is a Group Surgeon in the Occupational Air Force with anAPO, New York City. His sixteen-year-olddaughter, Georgia, is a U. of C. freshman anddoes volunteer work at Billings ..... Maj.James McBean spent 14 months in Englandas Chief of the E.E.N.T. service in the 112thGeneral Hospital. He is being released fromthe Army and on November 15 began an appointment as Consultant in Otolaryngologyat the Mayo Clinic ..... Maj. W. F. Beswick returned from Europe and has resumedthe practice of Neurosurgery in Buffalo, N.Y.'36. Maj. C. W. Bledsoe was recently released from active duty. He holds nine majorcampaign stars and saw service in Africa andEngland beginning July, 1943, as Group Surgeon with the 389th Bomber Group. He received a Unit Citation for the first PloestiRaid, Aug. I, 1943. Dr. Bledsoe has returnedto the private practice of Ob. and Gyn. inSeattle, Washington.'37. Among recent visitors were Maj. Carter Goodpasture, back from the Europeanarea; Lt. Col. Clinton Compere who is now onterminal leave and plans to resume his practice of orthopaedic surgery at 116 S. MichiganAve., Chicago; and Maj. Marcus David Burnstine, who has three battle stars for servicein the South Pacific ..... Ormand Julianhas been released from the Army and hasopened an office at 25 E. Washington St.,Chicago, for the practice of surgery ..... Lt.Col. John Post has resumed his practice at122 S. Michigan Ave., Chicago. Dr. Postserved with an anti-aircraft regiment on theWest Coast, September, 1940-43. Followingthis he was with a replacement depot inHawaii until September, 1945.'38. Among recent visitors was Capt. F. O.Lamb just back from Europe. After spending1942-44 at Brooke General Hospital, FortSam Houston, Texas, he was sent to LeMans,France, as Chief of Neuro-Psychiatry in the170th General Hospital. In June, 1945, he moved to the I74th General Hospital inArles, France, where he remained until thewar ended. Capt. Lamb was married in 1940..... Carl D. Strouse has been released fromthe Army and is in practice with his father inLos Angeles. He had 96 points on V-J Day,accumulated mostly in the Pacific in the earlydays ..... Capt. Daniel Glomset is workingin a GI ward in a hospital in England. He ismarried and has two children ..... Capt.Wm. F. Reynolds is radiologist for the 37thStation Hos.pital, A.P.O. 70, c/o P.M., SanFrancisco ..... Capt. A. K. Rodholm beganan asst. residency in Orthopedics at the University of Chicago on December 10. He spent2� years in Panama followed by 2 years atFoster General Hospital, Jackson, Miss.,where he was Chief of an Orthopedic Sectionaveraging 900 patients. He reports that G. A.Mulder '43 and N. W. Henry '43 are wardofficers at Foster General Hospital. Capt.Rodholm has two daughters-Ann, threeyears old, and Patricia, six months old.BLEDSOE WUODWARD'39. Lt. (j.g.) John H. Gifford has been retired from the medical corps of the Navy forphysical disability. He has a surgical residency at the California Hospital in Los Angeles ..... Lt. C. W. Burt, U.s.N., of Freemont, Michigan, has been in service almostfour years and recently was on terminal leave.He spent over a year on destroyer duty andwas in the North African invasion and on convoy and anti-submarine service in the NorthAtlantic, where he was torpedoed ..... Capt.Eugene Wiege is in charge of Orthopedics atCamp Claybourne, La. He has two children,Christine and Thomas. Capt. Wiege was inChicago recently to take the last part of hisAmerican Board of Surgery exams. He hasseen Maj. Carol Shukers '39, who has beenwith the Army in the European area and isnow teaching biochemistry at the Universityof Arkansas ..... Lt. Col. Edward H. Campvisited us while on furlough after a long andactive service in the European theater. Hismost recent assignments were at Rheims andVerdun, France, with a surgical unit. He expects to be released from the Army. WalterDuncan Hawk, recently Capt. in A.U.S.(MC), is now Instructor in the Departmentof Medicine and Physician in Student Healthat the U. of C. He' has two children, a daughter two years old and a son six months old.'40. Maj. James D. Majarakis visited theU. of C. while on leave in September. Afterserving his internship and residency at theEvanston Hospital, he was called to activeduty in 1942. Early in 1943 Maj. Majarakis went overseas with a general surgical team,His service record includes action in Normandy, northern France, the Ardennes, theRhineland, and northern Germany. He halfive battle stars and has been awarded a Distinguished Service Unit Citation and a Certificate of Merit ..... Philip J. Clark is inthe Navy Pre-Flight School, Athens, Georgia,'41. Harry P. Maxwell is practicing neurosurgery in Milwaukee and teaching in theMarquette Medical School. ... , Capt. H. C.Cappock has been with Air Evacuation for 18months' in Newfoundland, Hawaii, Okinawa,and now Guam. He has seen Maj. LawrencePolitz several times ..... Lt. Comdr. RobertW. Reid was in Ominata, Japan, in October.Since November, '43, he has been touring thePacific from the Aleutians to Australia- withhospital units and seaplanes and finally spenta year on a destroyer. .... Capt. A. F.Fricke and Capt. T. William Lester write fromGermany ... , . Capt. Joseph Ransohoff wasa November visitor at Billings. He spent tenmonths in France in neurosurgery and hasbeen assigned to further service at HalloranGeneral Hospital. Dr, Ransohoff has a threeyear-old daughter and a six-month-old son .. . . . Capt. Don Buchanan began a researchappointment at the U. of C. in January. Heserved in the Army as laboratory officer in station hospitals beginning in July, '42, and spent39 months overseas. After 22 months in Iceland, he went to England, then on to France.Recently he was in Germany, He reports thatCapt. Roger Morris spent a year in an adjoining hut in Iceland. He saw Maj. ShermanJennings, Flight Surgeon; in England in1944, and in September, 1945, he encounteredDick Cook in Heidelberg ..... William B.Neal was a recent Clinics visitor. He expectsto be out of service soon.'42. James A. McClintock is out of theArmy and is taking a surgical residency atBall Memorial Hospital, Muncie, Ind .....WIEGE COMPERECapt. Hugh Bennett is now at Fort Sheridan.He wears four battle stars which he receivedduring 18 months in the Philippines .... 'Lt. Edward R. Woodward returned in Sep·tember from 21 months in the central, south,and southwest Pacific on board an L.S.D. Hewas in eight major amphibious landings, beginning with the Marshalls, and from Aprilto July at Okinawa. He twice had the terrifying experience of watching a suicide planedive on them, but fortunately both were shotdown. In the Pacific he saw Bill Neal, BobHall, Francis Rook, Herb Trace, Bob Morris,and Frank Davis (all '42), Bob Lewis, '41, andMEDICAL ALUMNI BULLETIN 7lick Landau (former medical resident). Heaw Dick Simon, '44, in San Francisco in)ctober. Lt. Woodward is now stationed at:ireat Lakes ..... Lt. Charles Marshall hasieen assigned to the E.N.T. section of Hoff:ieneral Hospital, Santa Barbara, California.)pon arrival there he spent five weeks inorthopedics, under Robert B. Portis, '36, whos Chief of the Orthopedic Section ..... Maj.�eonard Asher, '37, is Chief of the GI serviceit that hospital. Lt. Marshall's work nowleals mainly with rehabilitation of men with.ar injuries ..... Capt. Edward Kinports wasn Chicago in November on terminal leave.'Ie plans to return to practice in Internationrl Falls, Minn. Capt. Kinports was married.0 Frances Bockrodt of Aurora, Ill., in 1943.He spent 20 months in New Guinea and theAdmiralry and Philippine Islands ..... Lt.j.g.) Robert P. Hall is waiting impatiently to�et out of the Navy. He was on one of theirst destroyers to shell the Philippines. Re:ently he has been located in the heart of theMojave Desert with the Marines, where he.ikes it, because there is land, lots of land!... Lt. George R. Barry is now stationed inNew York City ..... Capt. John Larrabee.s asst. resident in pediatrics at the U. of C.... Lt. James Fritz was here in Decemberm overseas leave following 2! years with theMarines. He has three battle stars for actionat Cape Gloucester, Peleliu, and Okinawa andalso a Unit Citation, First Marine Drive, atGuadalcanal. .... Dr. Donald Anderson,'ormer dental intern, served in the same division and returned on the same ship. Dr.Anderson married one of our former telepagegirls ..... Lillie Cutlar Walker is practicingpediatrics in Asheville, N.C.'43. Shirley A. Mayer completed an as-The next issue of the" Bulletin' , willbe replaced by the" Senior Year Book"for all dues-paying members of theAssociation. The" Year Book, "publishedby the Class of '46, will contain, inaddition to its many other features, alarge section devoted to the alumni.BULLETINof the Alumni AssociationThe University of ChicagoSCHOOL OF MEDICINEVOL. 2 JANUARY 1946 No.1H. P. JENKINSALLAN T. KENYON. Acting EditorHUBERTA LIVINGSTONE, Associate EditorHENRY T. RICKETTS, Associate EditorWILLIAM B. TUCKER, CLAYTON G. LOOSLlAssistant EditorsMRS. ROSEMARY JANDA, Reporter Jor Resident SiaffDRUCE HEINZEN, Reporter [or Senior ClassDELBERT M. BERGENSTAL, Reporter [or Junior ClassJACK KAHOUN, DANIEL ENERSON, PhotographersRUTH TCNER, Assistant to SecretaryPrice of yearly subscription for nonmembers, $1.00;price of single copies, 25 cents. sistant residency at Babies Hospital in NewYork in June, 1945, and was married in Julyto Dr. W. A. Barnes, an asst. professor ofsurgery at Cornell University. She is now asst.pediatrician at the New York Hospital andan instructor in pediatrics ..... Lt. Colin G.Thomas, Jr., entered the Army in July, '45,after completing 18 months of a surgicalresidency at the University Hospitals, IowaCity. He is now ward surgeon at Camp Breckinridge, Ky ..... Capt. Walter R. Hearnewas assigned to the Army Air Forces following completion of his internship, and has sincebeen located in various AAF station hospitalsin the U.S. In October he was at SeymourJohnson Field, Goldsboro, N.C ..... Capt.William Stone is at Dugway ProvingGrounds, Tooele, Utah ..... Capt. WilliamE. Reynolds is located at Miller Field, StatenIsland, N.Y. .... Y. T. Oester is at PercyJones Hospital, Battle Creek, Mich .....Among Clinics visitors were Lt. Herbert C.Johnson, on his way from Carlisle Barracksto Lawson General Hospital, Atlanta, Ga.,and Lt. Beverly Cope just back from Luxembourg, where he assisted with the care ofprisoners of war. Lt. Cope is now on anE.N.T. service in the 306th General Hospital, Camp Seibert, Alabama, but he expectsservice in the Pacific soon ..... Lt. (j.g.)Arthur M. Gray was a member of the SecondMarine Division, which made the originalattempt at landing at Okinawa, where theyspent one week under fire. He was sent on toSaipan, where he was injured, followed byhospitalization in Hawaii. He is now at MareIsland and hopes to be out of service soon andto specialize in pediatrics.44. Lt. (j.g.) Paul G. Wolff is in the U.S.Fleet Sonar School at San Diego in a dispensary with another physician and two dentists.They have 35 beds and a small operatingroom ..... Lt. Vernon Jim is in the Schoolof Aviation Medicine at Randolph Field..... Lt. (j.g.) Raymond Goodman is nowmedical resident at Los Angeles CountyGeneral Hospital. He saw Maj. BenjaminMiller and Dr. Omar Fareed at the meetingof the Los Angeles Heart Association. Dr.Oberrnayer is attending physician in dermatology, Dr. G. Carpenter is attending hematologist, and Dr. Lee Pearce is resident inpsychiatry at the L.A.e.G.H ..... Lt. (j.g.)David L. Rubinfine wrote from the navalseparation center in Memphis in November,where he was examining men eligible for discharge. He reports that Andy Canzonettishould now be in Japan ..... Bruce F. Grottsis asst. resident in pediatrics at the Children'sHospital of Pittsburgh and is a teaching fellow in the University. He hopes to be at theMilwaukee Children's Hospital next year..... Lt. J. H. Carey writes from Manila of a25-day trip on the high seas in a crowdedtransport. He has had 110 medical work for2! months. Most of the Army personnel livein tents, and they are not enjoying the rainyseason ..... Lt. J. Folsom also is in Manila.Dr. Kinyon reports that thirteen members ofthe class of '44 are now on the resident staffat Billings and more are located in Chicago.'45. Lt. (j.g.) Thomas W. Anderson is atthe U.S. Naval Hospital, Oakland, California ..... Robert G. Langdon is in Stocktorr,California, at the San Joaquin Hospital. ....Lt. Michael Bonfiglio writes from Fort Lewis,Washington, that he is keeping busy as wardsurgeon on an orthopedic ward of 81 patients.He successfully completed Part I of the orthopedic boards recently ..... David T. Hellyer,at the Kings County Hospital, Seattle, hasseen no one but Schlagetter, and is anxiousfor news from other classmates. New Arrivals-1945Lt. and Mrs. T. L. Hopple, Diane Lorraine,Jan. 26Dr. and Mrs. F. Kredel, Nancy Cooper,Jan. 29Maj. and Mrs. J. McBean, Dorothy Jean,Feb. 18Dr. and Mrs. K. H. Sponsel, Susan Scott,Feb. 24Dr. and Mrs. L. W. Wimby, Sheila Dorene,Feb. 24Lt. and Mrs. J. T. Wharton, Barbara Joan,Mauhl7 .Lt. and Mrs. J. M. Beal (Mary Phemister),John, jr., April 14Capt. and Mrs. J. Ransohoff, Joseph Lewis,AprilDr. and Mrs. L. Thomas, Kathryn Anne,April 25Lt. Col. and Mrs. e. Compere, Mary Katherine, April 29Dr. and Mrs. W. Bunge, William Samuel,May 2Dr. and Mrs. A. Evans, daughter, MayDr. and Mrs. G. H. Mundt, daughter,May 12Capt. and Mrs. H. Reames, Hal, Jr., June 13Capt. and Mrs. N. N. Tepper, Robert Ronald, June 26Dr. and Mrs. J. R. Russell, Thomas William,June 26Lt. and Mrs. J. W. Findley, Thomas Walker,July IIDr. and Mrs. W. L. Palmer, Henry Ricketts,July 24Dr. and Mrs. A. K. Rodholm, Patricia,July 29Dr. and Mrs. D. Tschetter, John Harold,Aug. 17Dr. and Mrs. C. D. Strouse, Jean, SeptemberLt. and Mrs. H. A. Frank, David Herbert,Sept. IDr. and Mrs. F. Gordon, William, Sept. 7Dr. and Mrs. S. Taylor, Charles Ellett,Sept. 9Capt. and Mrs. F. M. Owens, Jr., Sally,Sept. 17Dr. and Mrs. E. Hathaway, Stephen Allen,October ISMr. and Mrs. A. Christy (Dr. Vera Kable),Richard Artemus, Oct. 18Dr. and Mrs. E. Eby, Robert George, Oct. 20Lt. and Mrs. R. Rasmussen, Karen Regine,Oct. 23Dr. and Mrs. R. W. Janda, Mary Kathryn,Nov. 7Dr. and Mrs. R. L. Beal, daughter, Nov. 12Dr. and Mrs. C. C. Mahar, Jr., Chauncey C.III, Nov. 14Dr. and Mrs. E. B. Struxness, Mary Ann andMartha Jane, Nov. 30Lt. (j.g.) and Mrs. T. F. Thornton, SusanMarie, Dec. 12Marriages-1945Dr. J. S. Gordon, Lilfred Wright, Feb. 16Lt. A. Pizzo, Patricia Murphy, June ISDr. 1. C. Tiholiz, Jane Crosbie, June 16Dr. G. F. Krakowka, Ann Hoyt, June 22Dr. P. E. Strueh, Ruth Hurt, June 23Dr. J. McGrath, Charlotte Balzer, June 30Dr. Shirley A. Mayer, Dr. W. A. Barnes,JulyDr. G. Bogardus, Ann Burks, Aug. 4Dr. F. S. Ryerson, Anne LeClear, Aug. 7Dr. E. R. Mindell, June Abrams, Sept. ISDr. R. Green, Beverly Horn, Oct. 6Dr. A. W. Marcovich, Jacqueline Front,Oct. 7Dr. H. LeVeen, Dr. Jeanette Rubicuis,Oct. 12 'Dr. C. Johnson, Jean Reid, Dec. I8 MEDICAL ALUMNI BULLETINTHE FACULTYHUGGINSCHARLES HUGGINSAs this BULLETIN goes to press, we understand with regret that Dr. CharlesHuggins, Professor of Surgery and distinguished investigator and teacher, hasresigned as of July I, 1946, to accept thechair in urology at Johns Hopkins University and to become director of theBrady Urological Institute. Dr. Hugginswas born in 1901 in Halifax, Nova Scotia.He attended school at Acadia, Nova Scotia, and graduated from Harvard University Medical School with the class of 1924.From 1924 to 1927 he served an internship and residency at the Universityof Michigan. In 1927 Dr. Hugginscrossed the threshold on a plank beforethe floors were laid in the University ofChicago Clinics. Since that time he hasbeen a member of the Clinics Staff.Among his many contributions are thoseon the deposition of bone in bladder mucosa, on the mechanism of the distribution of hematopoietic bone marrow, onthe regulation of prostatic secretion, culminating in the demonstration of theameliorative effects of estrogens and orchidectomy on prostatic cancer, one ofthe notable advances of our time, and onthe nature of tumors of the Sertoli cells.Dr. Huggins has received many honorsand borne them gracefully. We havenever wished Johns Hopkins this kind ofgood fortune. Dr. A. J. Carlson has been appointed on apart-time basis as director of the ResearchCouncil on Problems of Alcohol, New York .. . . . Dr. Lucille Watt, Instructor in Surgery(Anesthesia), on Sept. I became AttendingAnesthetist at Presbyterian Hospital, Chicago ..... Col. Esmond R. Long of Philadelphia, a former member of our faculty andchief consultant on tuberculosis to the Surgeon General of the Army, has been lent tothe Veterans Administration, on request ofMaj. Gen. Paul R. Hawley, acting surgeongeneral. Col. Long recently returned fromGermany, where he was attached to the Officeof Military Government ..... Dr. SigmundF. Bradel, former Assoc. Prof. of Dentistry,has opened an office at 55 East Washington,Chicago, for the practice of oral roentgenology ..... Dr. Earl Walker is Chief Neurosurgeon at Cushing General Hospital, Framingham, Mass. He reports that Capt. W. C.Dine is at Ashford General Hospital, WhiteSulphur Springs, W.Va., and Van der Laanat Fletcher General Hospital. .... Dr. Henry Houghton, formerly Director of the U. ofC. Clinics, and for a long time a prisoner ofthe Japs in Peiping, was a recent visitor. Hewas flown back from China ..... Maj. Heinrich Kobrak has been discharged from theArmy and has returned to join the otolaryngology staff ..... Dr. C. Howard Hatcher,. Assoc. Prof. of Orthopedic Surgery, left byplane on Dec. 26 for four months' service asOrthopedic Consultant to the U.N.R.R.A. inGreece ..... Ruth E. Wentworth, secretaryfor 25 years in the Office of the Dean of theMedical School, has resigned. She will remainat the U. of C. in the Office of Admissions..... Major Gustave Freeman returns to Chicago as Assistant Professor of Medicine aftera five years absence in the Army ..... Lt.Alfred Klein has resumed his teaching in theDepartment of Medicine.Maj. Francis Phillips has been appointed asResearch Associate (Instructor) in Surgery.((barIton �. �t[kIt is with a deep sense of loss thatthe members of the Association willlearn of the death of Mr. Charlton T.Beck on January 23,1946. Mr. Beckhad been Executive Secretary of theAlumni Association for more thanseventeen years, and was of material assistance in aiding in the reorganization of the Alumni Association of the School of Medicine in1944. His loss will be keenly felt.Hospital AdministrationMr. Ray Brown, formerly superintenent of the Baptist Hospital, BowmanGray School of Medicine, Winston-Salem,North Carolina, has become assistant superintendent of the University of ChicagoClinics and will deal chiefly with the outpatient department. Mr. Brown was bornon September 26, 1913, at Shelby, North Carolina, attended school in Shelby, graduated from the University of North Carolina in 1937, and received a Master's degree in hospital administration at theUniversity of Chicago in 1943. He wassuccessively county manager of theCleveland County Hospital, North Carolina, and superintendent of the ShelbyNorth Carolina Hospital before going toBowman-Gray. AUSTIN BRUESDr. Austin Moore Brues has becomeAssociate Professor of Medicine withduties divided between the Departmentof Medicine and the Institute of Radiobiology and Biophysics. Dr. Brues wasborn April 25, 1906, in Milwaukee, Wisconsin. He was educated at the RoxburyLatin School, Harvard College, and Harvard University Medical School, obtaining his M.D. in 1930. He interned atMassachusetts General Hospital andserved a residency at the HuntingtonMemorial Hospital under Joseph C. Aub.In 1935-36 he studied at the Royal Cancer Hospital, .London, with E. L. Kennaway. Until he joined the "Metallurgy"project in 1944, Dr. Brues taught medicine at Harvard, practiced, and devotedhimself to research in cancer. His interests were in nucleic acid metabolism, cytology of tumors, growth and cell division, chemotherapy, tissue cultures, andlater in problems of traumatic shock. Heis married and has three children.Testimonial DinnerThe former chief residents and members of the Department of Surgery gave atestimonial dinner in honor of Dr. D. B.Phemister on December 4 at the Windermere East Hotel. This was the occasion ofhis twentieth anniversary as professorand chairman of the Department of Surgery. Dr. Phemister was presented withthe Phemister Twentieth AnniversaryVolume, which consisted of the Decemberissue of the Annals of Surgery, made up ofpapers written by chief residents andmembers of the Department of Surgery.A luncheon followed by a scientificprogram of papers by the present membersof the surgical resident staff was heldearlier in the day.